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An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-28 Manoswini Dash, Bhawna Mahajan, Ghulam Mehdi Dar, Parameswar Sahu, Sundeep Singh Saluja
Cardiovascular diseases are the foremost contributor to global mortality, presenting a complex etiology and an expanding array of risk factors. Coronary artery disease characterized by atherosclerotic plaque build-up in the coronary arteries, imposes significant mortality and financial burdens, especially in low- and middle-income nations. The pathogenesis of coronary artery disease involves a multifaceted
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Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2 Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-27 Yong Luo, Liping Li, Qiwen Hu, Ziyu Zhang, Faying Liu, Yongbao Peng, Yang Zou, Lina Chen
Given the high concentration of iron in the micro-environment of ovarian endometriosis, it is plausible to hypothesize that ectopic endometrial cells may be more susceptible to undergoing ferroptosis. Manipulation of ferroptosis has been explored as a potential therapeutic strategy to treat related diseases. In this study, we examined the impact on ectopic endometrial stromal cells (EESCs) of iron
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The Application of Brain Organoid for Drug Discovery in Mitochondrial Diseases Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-27 Kristina Xiao Liang
Mitochondrial diseases are difficult to treat due to the complexity and multifaceted nature of mitochondrial dysfunction. Brain organoids are three-dimensional (3D) structures derived from human pluripotent stem cells designed to mimic brain-like development and function. Brain organoids have received a lot of attention in recent years as powerful tools for modeling human diseases, brain development
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PLA inhibits TNF-α-induced PANoptosis of prostate cancer cells through metabolic reprogramming Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-25 Yinghui Hao, Fangmei Xie, Jieyi He, Chenqiong Gu, Ying Zhao, Wenfeng Luo, Xiaoyu Song, Jian Shen, Li Yu, Zeping Han, Jinhua He
Previous studies have shown that phenyllactic acid (alpha-Hydroxyhydrocinnamic acid, 2-Hydroxy-3-phenylpropionic acid, PLA), a type of organic acid metabolite, has excellent diagnostic efficacy when used to differentiate between prostate cancer, benign prostatic hyperplasia, and prostatitis. This research aims to explore the molecular mechanism by which PLA influences the PANoptosis of prostate cancer
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Identification and validation of LINC01322 as a potential prognostic biomarker and oncogene promoting tumor progression in lung adenocarcinoma Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-23 Lizhong Zeng, Ke Mi, Lei Peng, Haimei Wen, Ting Jiao, Xin Lyu, Tong Jiao, Yang Chen, Jingyan Yuan, Long Zhang, Shuanying Yang
Our study identified a novel long noncoding RNA, LINC01322, that acts as an oncogene in lung adenocarcinoma progression. Cytoplasmic and nuclear RNA purification assays indicated that LINC01322 was localized in the cytoplasm and nucleus. Gene set enrichment analysis revealed the involvement of LINC01322 in the regulation of cell proliferation, migration, and the Janus kinase/signal transducer and activator
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S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-14 Liang Yang, Jiang Liu, Jing Yin, Yan Li, Jianmin Liu, Daoquan Liu, Zhen Wang, Michael E DiSanto, Weibing Zhang, Xinhua Zhang
Benign prostatic hyperplasia (BPH) is one of the most common diseases in elderly men worldwide that may result in lower urinary tract symptoms (LUTS). At present, the specific pathophysiological mechanism for BPH/LUTS LUTS remains unclear. S100 calcium binding protein A4 (S100A4), a member of the calcium binding protein family, regulates a variety of biological processes including cell proliferation
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The functional significance of circRNA/miRNA/mRNA interactions as a regulatory network in lung cancer biology Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-13 Shengnan Jia, Ling Yu, Lihui Wang, Liping Peng
Lung cancer, the leading cause of cancer-related deaths, presents significant challenges to patients due to its poor prognosis. Recent research has increasingly implicated circular RNAs in the development and progression of lung cancer. These circular RNAs have been found to impact various aspects of tumor behavior, including proliferation, metastasis, cell cycle regulation, apoptosis, cancer stem
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Identification of PKM2 as a Pyroptosis-Related Key Gene Aggravates Senile Osteoporosis via the NLRP3/Caspase-1/GSDMD Signaling Pathway Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-09 Zilin Li, Bo Wang, Ruoyu Wang, Zhichao Zhang, Jian Xiong, Xiaoyun Wang, Yan Ma, Lizhi Han
Senile osteoporosis—alternatively labeled as skeletal aging—encompasses age-induced bone deterioration and loss of bone microarchitecture. Recent studies have indicated a potential association between senile osteoporosis and chronic systemic inflammation, and pyroptosis in bone marrow-derived mesenchymal stem cells is speculated to contribute to bone loss and osteoporosis. Therefore, targeting pyroptosis
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Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-08 Jinxiu Li, Xiping Qin, Weimin Xu, Hongliang Zhang, Songqing Huang, Yufang Yang, Mengyuan Qin, Zhengcheng Mi, Xiaobin Zhong
Chronic kidney disease (CKD) has a high incidence and poor prognosis; however, no effective treatment is currently available. Our previous study found that the improvement effect of the herb pair of Rhubarb-Astragalus on CKD is likely related to the inhibition of the TGF-β1/p38-MAPK pathway. In the present study, a p38-MAPK inhibitor was used to further investigate the inhibitory effect of Rhubarb-Astragalus
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Xuetongsu attenuates bone destruction in collagen-induced arthritis mice by inhibiting osteoclast differentiation and promoting osteoclast apoptosis Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-08 Hao Zheng, Yunzhe Li, Yasi Deng, Huanjie Li, Xinyang Shen, Haokai Lin, Yong Yang, Xing Tian, Bin Li, Hanwen Yuan, Wenbing Sheng, Wei Wang, Huanghe Yu
Tujia ethnomedicine Xuetong (the stems of ) have been widely used in folk for rheumatoid arthritis (RA), which can alleviate rheumatic pain through liquor soaking in folk. In this study, we aimed to evaluate the pharmacological effects and underlying mechanism of Xuetongsu (a key chemical component of Xuetong) on bone destruction. In our previous study, it was found that Xuetong extract can reduce
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Corrigendum to “Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice” [Int. J. Biochem Cell Biol. 81 (2016) 383–392] Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-07 Ahmed Bettaieb, Eleonora Cremonini, Heeteak Kang, Jiye Kang, Fawaz G. Haj, Patricia I. Oteiza
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Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-04 Meixia Huang, Shuyi Duan, Qiwen Zhang, Lianxia Guo, Zifei Qin, Jing Yang
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Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-02 Yeqi Li, Cui Yin, Jinhong Jiang, Huan Yang, Feifei Zhang, Yanhong Xing, Wuyang Wang, Chen Lu
Microglial are major players in neuroinflammation that have recently emerged as potential therapeutic targets for neuropathic pain. Glucose metabolic programming has been linked to differential activation state and function in microglia. Tumor necrosis factor α-induced protein 8-like-2 (TNFAIP8L2) is an important component in regulating the anti-inflammatory response. However, the role of TNFAIP8L2
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Exploring advances in single particle CryoEM with apoferritin: From blobs to true atomic resolution Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-02-01 Gowtham ThambraRajan Premageetha, Kutti R. Vinothkumar, Sucharita Bose
Deciphering the three-dimensional structures of macromolecules is of paramount importance for gaining insights into their functions and roles in human health and disease. Single particle cryoEM has emerged as a powerful technique that enables direct visualization of macromolecules and their complexes, and through subsequent averaging, achieve near atomic-level resolution. A major breakthrough was recently
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Discriminatory power of a circulating multi-noncoding RNA panel in acute coronary syndrome subtypes: Towards precision detection Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-26 Sara H.A. Agwa, Sherif Samir Elzahwy, Nourhan Hossam, Yahia A. Yahia, Shaimaa Hamady, Nadine Sherif, Ahmed Elshazly, Reham M. Darwish, Jomana Osama Hashim, Mahmoud Ashraf Adly, Aya M. Abd Elsamee, Rania Shamekh, Marian Maher Salib Roushdy, Marwa Matboli
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AKT2 Deficiency Alleviates Doxorubicin-induced Cardiac Injury via alleviating oxidative stress in cardiomyocytes Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-28 Jiawen Chen, Xiaozhi Xu, Yuru Shao, Xiaohong Bian, Ruiyan Li, Yubin Zhang, Yibei Xiao, Meiling Lu, Qizhou jiang, Yuan Zeng, Fangrong Yan, Junmei Ye, Zhe Li
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DNMT1 Y495C mutation interferes with maintenance methylation of imprinting control regions Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-26 Sumana Choudhury, Anuhya Anne, Minali Singh, John Richard Chaillet, Kommu Naga Mohan
Hereditary Sensory and Autonomic Neuropathy Type 1E (HSAN1E) is a rare autosomal dominant neurological disorder due to missense mutations in DNA methyltransferase 1 (DNMT1). To investigate the nature of the dominant effect, we compared methylomes of transgenic R1wtDnmt1 and R1Dnmt1Y495C mouse embryonic stem cells (mESCs) overexpressing WT and the mutant mouse proteins respectively, with the R1 (wild-type)
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The Role of High Mobility Group AT-hook 1 in Viral Infections: Implications for Cancer Pathogenesis Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-24 Esma’il Akade, Shahram Jalilian
The crucial role of high mobility group AT-hook 1 (HMGA1) proteins in nuclear processes such as gene transcription, DNA replication, and chromatin remodeling is undeniable. Elevated levels of HMGA1 have been associated with unfavorable clinical outcomes and adverse differentiation status across various cancer types. HMGA1 regulates a diverse array of biological pathways, including tumor necrosis factor-alpha/nuclear
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Jun/Fos promotes migration and invasion of hepatocellular carcinoma cells by enhancing BORIS promoter activity Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-26 Longjun Xian, Yimei Xiong, Lu Qin, Ling Wei, Siqi Zhou, Qinda Wang, Qiang Fu, Mingmei Chen, Yang Qin
The Brother of the Regulator of Imprinted Sites (BORIS), as a specific indicator of hepatocellular carcinoma, exhibits a significant increase in expression. However, its upstream regulatory network remains enigmatic. Previous research has indicated a strong correlation between the Hippo pathway and the progression of hepatocellular carcinoma. It is well established that the Activator Protein-1 (AP-1)
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Variant of uncertain significance Arg866Cys enhances disorderedness of h-BRCA1 (759-1064) region Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-17 Neha Mishra, Suchita Dubey, Anchala Kumari, M. Quadir Siddiqui, Ekaterina Kuligina, Ashok K. Varma
High structural flexibility has been reported in the central region of BRCA1, which hinders the structural and functional evaluations of mutations identified in the domain. Additionally, the need to categorize variants of unknown significance (VUS) has increased due to the growth in the number of variants reported in clinical settings. Therefore, unraveling the disease-causing mechanism of VUS identified
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Sulfasalazine ameliorates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and nuclear factor-kappaB pathways Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-19 Hai-peng Cheng, Xing-wen Bao, Yong-yu Luo, Yang-hang Li, Yan Zhou, Qing-zhong Hua, Yu-jia Qiu, Xin-yue Liang, Yan-hong Huang, Wei Liu, Si-yuan Tang, Dan-dan Feng, Chen Li, Zi-qiang Luo
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has a high mortality rate and incidence of complications. The pathophysiology of ALI/ARDS is still not fully understood. The lipopolysaccharide (LPS)-induced mouse model of ALI has been widely used to study human ALI/ARDS. Sulfasalazine (SASP) has antibacterial and anti-inflammatory effects and is used for treating inflammatory bowel
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To what extent may aminochrome increase the vulnerability of dopaminergic neurons in the context of Parkinson's disease Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-19 Abdeslam Chagraoui, Youssef Anouar, Philippe De Deurwaerdere, Hugo R. Arias
Parkinson's disease (PD) is a neurodegenerative disorder that progresses over time and is characterized by preferential reduction of dopaminergic neurons in the substantia nigra. Although the precise mechanisms leading to cell death in neurodegenerative disorders, such as PD, are not fully understood, it is widely accepted that increased oxidative stress may be a prevalent factor contributing to the
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Recent advances in the investigation of fusion RNAs and their role in molecular pathology of cancer Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-19 Si-Mei Xu, Yuning Cheng, Harry Fisher, Michael Janitz
Gene fusions have had a significant role in the development of various types of cancer, oftentimes involved in oncogenic activities through dysregulation of gene expression or signalling pathways. Some cancer-associated chromosomal translocations can undergo backsplicing, resulting in fusion-circular RNAs, a more stable isoform immune to RNase degradation. This stability makes fusion circular RNAs
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Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-12 Hui Wang, Min Tang, Erli Pei, Ying Shen, Aili Wang, Moubin Lin
In view of the tumor-inhibiting effect of α-santalol in various cancers and the role of E2F transcription factor 1 (E2F1) as an important target for anticancer research, this study investigates the relation between α-santalol and E2F1, as well as the effect of α-santalol on liver cancer progression and the corresponding mechanism. Concretely, liver cancer cells were treated with different concentrations
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The role of α7 nicotinic acetylcholine receptors in post-acute sequelae of covid-19 Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-11 Maryna Skok
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BNIP3 in hypoxia-induced mitophagy: Novel insights and promising target for non-alcoholic fatty liver disease Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-11 Meiyuan Tian, Jing Hou, Zhe Liu, Zhanquan Li, Dengliang Huang, Yaogang Zhang, Yanyan Ma
BNIP3 localizes to the outer mitochondrial membrane, has been demonstrated to be extensively involved in abnormalities to mitochondrial metabolic function and dynamicsand in non-alcoholic fatty liver disease (NAFLD). However, its role in NAFLD under hypoxia remains unclear. This study aimed to investigate the expression and the role of BNIP3 in NAFLD under hypoxia, and explore its involvement in regulating
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Hedgehog signalling in CD4+ T helper cell polarisation Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2024-01-11 Joachim Hanna, Maike de la Roche
CD4+ T cells are critical in orchestrating immune responses against various pathogens and cancer but can also be drivers of autoimmune disease, allergy and pro-tumour responses. Naïve CD4+ T cells polarise into specialised T helper cell subsets with unique effector functions. While the guiding transcription factors and effector molecules of the T helper cell lineages are well understood, the signalling
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Corrigendum to “GOLGI: cancer cell fate control” [Int. J. Biochem. Cell Biol. 145 (2022) 106174] Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-12-20 Marta Martins, Ana Sofia Fernandes, Nuno Saraiva
Abstract not available
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The role of zinc finger proteins in the fate determination of mesenchymal stem cells during osteogenic and adipogenic differentiation Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-12-23 Bolun Li, Shibo Liu, Ze He, En Luo, Hanghang Liu
Zinc finger proteins (ZFPs) constitute a crucial group of transcription factors widely present in various organisms. They act as transcription factors, nucleases, and RNA-binding proteins, playing significant roles in cell differentiation, growth, and development. With extensive research on ZFPs, their roles in the determination of mesenchymal stem cells (MSCs) fate during osteogenic and adipogenic
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Molecular and cellular evidence of a direct interaction between the TRAF2 C-terminal domain and ganglioside GM1 Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-12-22 Anastasia De Luca, Fiorella Faienza, Chiara Fulci, Eleonora Nicolai, Paolo Calligari, Camilla Palumbo, Anna Maria Caccuri
TNF receptor-associated factor 2 (TRAF2) is involved in different cellular processes including signal transduction and transcription regulation. We here provide evidence of a direct interaction between the TRAF domain of TRAF2 and the monosialotetrahexosylganglioside (GM1). Previously, we showed that the TRAF domain occurs mainly in a trimeric form in solution, but it can also exist as a stable monomer
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PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-12-13 Gang Wu, Shaolei Qin, Ke Gu, Yanjun Zhou
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Corrigendum to “Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway” [Int. J. Biochem. Cell Biol. 116 (2019) 105620] Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-12-05 Jinpeng Lv, Ying Fu, Rongyin Gao, Jiawen Li, Maofan Kang, Guoqiang Song, Changjun Yun
Abstract not available
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IL-22 relieves hepatic ischemia-reperfusion injury by inhibiting mitochondrial apoptosis based on the activation of STAT3 Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-11-28 Zhengchen Jiang, Wanzhen Li, Shuna Yu, Xuyang Wang, Hongxin Jiang, Chen Bai, Ming Li, Fangfang Chu, Jiying Jiang, Xiaomin Ma
Introduction Interleukin-22 (IL-22) has been proven to exhibit a protective role in hepatic ischemia-reperfusion injury (HIRI). This study aimed to explore the change of IL-22 and IL-22 receptor 1 (IL-22R1) axis in HIRI and its role in mitochondrial apoptosis associated with STAT3 activation. Materials and Methods I/R mice were examined for the expression of IL-22, IL-22R1 and IL-22BP. The roles of
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Epigenetic modification of m6A methylation: Regulatory factors, functions and mechanism in inflammatory bowel disease Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-11-28 Yanping Wang, Chaoyue Chen, Wei Yan, Yu Fu
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Tumor-derived microparticles promoted M2-like macrophages polarization to stimulate osteosarcoma progression Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-11-11 Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Microparticles (MPs) are a heterogeneous subpopulation of extracellular vesicles that originate from the plasma membranes of cells. There is increasing evidence that tumor-derived MPs (T-MPs) play a significant role in tumor progression and immune response in cancer. In our study, we found an increased secretion of MPs in osteosarcoma tissues obtained from metastatic patients. These T-MPs promoted
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Tumor protein D52 (isoform 3) induces NF-κB – STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-11-05 K.K. Sruthi, Sirisha Natani, Ramesh Ummanni
In prostate cancer (PCa) patients, a proto-oncogene Tumor protein D52 (TPD52) is overexpressed, and it is involved in different cellular functions. In this study, we report that TPD52 expression is positively associated with the emergence of neuroendocrine PCa (NEPC). With overexpression of TPD52 in LNCaP cells, we found neuroendocrine differentiation (NED) of cells in in-vitro and distinct NED features
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ER-mitochondria contact sites in mitochondrial DNA dynamics, maintenance, and distribution Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-11-04 Hema Saranya Ilamathi, Marc Germain
Mitochondria are central cellular metabolic hubs. Their function requires proteins encoded by nuclear DNA, but also mitochondrial DNA (mtDNA) whose maintenance is essential for the proper function of the organelle. Defective mtDNA maintenance and distribution are associated with mitochondrial diseases. mtDNA is organized into nucleo-protein complexes called nucleoids that dynamically move along the
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CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-10-31 Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Centromere protein L (CENPL) is involved in the mitotic process of eukaryotic cells and the development of various types of cancer. However, its role in hepatocellular carcinoma (HCC) remains unclear. This study aimed to investigate the expression and clinical significance of CENPL in HCC, and explore its involvement in regulating HCC cell proliferation, apoptosis, cell cycle, and glycolysis both in
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Talin mechanotransduction in disease Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-10-31 Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
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UBC9 stabilizes PFKFB3 to promote aerobic glycolysis and proliferation of glioblastoma cells Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-10-28 Zhaoyuan Meng, Xueli Bian, Leina Ma, Gang Zhang, Qingxia Ma, Qianqian Xu, Juanjuan Liu, Runze Wang, Jie Lun, Qian Lin, Gaoxiang Zhao, Hongfei Jiang, Wensheng Qiu, Jing Fang, Zhimin Lu
Cancer cells prefer to utilizing aerobic glycolysis to generate energy and anabolic metabolic intermediates for cell growth. However, whether the activities of glycolytic enzymes can be regulated by specific posttranslational modifications, such as SUMOylation, in response to oncogenic signallings, thereby promoting the Warburg effect, remain largely unclear. Here, we demonstrate that phosphofruct
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The bcl6 corepressor mutation regulates the progression and transformation of myelodysplastic syndromes by repressing the autophagy flux Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-10-24 Jia-Nan Chen, Jia-Cheng Jin, Juan Guo, Ying Tao, Fan-Huan Xu, Qi Liu, Xiao Li, Chun-Kang Chang, Ling-Yun Wu
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Differential regulation of fibronectin expression and fibrillogenesis by autocrine TGF-β1 signaling in malignant and benign mammary epithelial cells Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-10-21 Michael M. Sofroniou, Christopher A. Lemmon
Remodeling of the extracellular matrix (ECM) is a key hallmark of cancer progression. A critical component of ECM remodeling is the assembly of the glycoprotein fibronectin (FN) into insoluble fibrils, which provide a scaffold for invading vascular endothelial cells and escaping cancer cells, as well as a framework for collagen deposition and oncogenic cytokine tethering. FN fibril assembly is induced
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Immunosenescence and macrophages: From basics to therapeutics Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-10-20 Hongkang Zhu, Fanglin Shen, Tingting Liao, He Qian, Yu Liu
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DNA mismatch repair deficient cancer – Emerging biomarkers of resistance to immune checkpoint inhibition Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-10-18 Kirsten Brooksbank, Sarah A. Martin
The DNA mismatch repair pathway is involved in the identification, excision, and repair of base-base mismatches and indel loops in the genome. Mismatch repair deficiency occurs in approximately 20% of all cancers and results in a type of DNA damage called microsatellite instability. In 2017, the immune checkpoint inhibitor, Pembrolizumab, an anti-PD-1 therapy, was approved for use in all unresectable
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MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-10-05 Yue Jiang, Lu Liu, Yi-Xuan Deng, Jie Zhang, Ai-Hua Ye, Fang-Lin Ye, Bai-Cheng He
Bone morphogenetic protein 9 (BMP9) has been validated as one of the most potent osteoinduction factors, but its underlying mechanism remains unclear. As a member of the matrix metalloproteinase (MMP) family, MMP13 may be involved in regulating the lineage-specific differentiation of mouse embryonic fibroblasts (MEFs). The goal of this study was to determine whether MMP13 regulates the osteoinduction
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ROCK inhibition reduces the sensitivity of mutant p53 glioblastoma to genotoxic stress through a Rac1-driven ROS production Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-09-30 Yuli Thamires Magalhaes, Fabio Luis Forti
Resistance to radio and chemotherapy in Glioblastoma (GBM) is correlated with its malignancy, invasiveness, and aggressiveness. The Rho GTPase pathway plays important roles in these processes, but its involvement in the GBM response to genotoxic treatments remains unsolved. Inhibition of this signaling pathway has emerged as a promising approach for the treatment of CNS injuries and diseases, proving
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Wherefore Art Tau? Functional importance of site-specific tau phosphorylation in diverse subcellular domains Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-09-29 Amanda Schneeweis, Daniel T.S. Pak
Tau has canonically been considered as an axonal protein, but studies have observed tau localization in other subcellular domains of neurons. This relocated tau has been identified in both physiological and pathological conditions, and it is often labeled mislocalized. Furthermore, these forms of tau are referred to as “hyperphosphorylated” without specifying the phosphosites involved. On the contrary
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CircABPD1 alleviates oxidative lung injury of bronchopulmonary dysplasia through regulating miR-330-3p/HIF1α axis Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-09-01 Huimin Li, Ke Ma, Heng Dou, Linjie Liu, Yun Qian, Shushu Li, Jingjing Chen, Shuping Han, Xiaoqi Gu, Jing Yin
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Role of innate lymphoid cells in cancer metastasis Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-09-04 Julia Moreno-Vicente, Timotheus YF Halim
Metastatic spread of cancer accounts for most cancer-related deaths. Cancer seeding in secondary organs requires reprogramming of the local stromal and immune landscape, which ultimately supports tumour growth. Yet, the cellular and molecular mechanisms that promote this tumour-permissive environment remain largely unknown. Innate lymphoid cells (ILCs) have recently been shown to modulate the immune
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Circadian control of cisplatin-DNA adduct repair and apoptosis in culture cells Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-08-12 Jeseok Jeon, Sanggon Lee, Jeong-Min Park, Tae-Hee Lee, Tae-Hong Kang
Cisplatin, a widely prescribed chemotherapeutic agent for treating solid tumors, induces DNA adducts and activates cellular defense mechanisms, including DNA repair, cell cycle checkpoint control, and apoptosis. Considering the circadian rhythmicity displayed by most chemotherapeutic agents and their varying therapeutic efficacy based on treatment timing, our study aimed to investigate whether the
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Using single molecule imaging to explore intracellular heterogeneity Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-08-15 James A. Galbraith, Catherine G. Galbraith
Despite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular condensates such as liquid-liquid phase separations (LLPSs) or non-liquid, functionally significant molecular aggregates, including synaptic densities, nucleoli, and
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Cancer: Phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-07-25 Thomas A. Wright, Alistair O. Gemmell, Gonzalo S. Tejeda, Connor M. Blair, George S. Baillie
Phosphodiesterase type 4 (PDE4) enzymes specifically hydrolyse cAMP in many cell signalling systems that are transduced by hormones and other primary messengers. The physiological function of the four PDE4 subfamilies (A, B, C and D) are numerous and varied due to the differentially localised plethora of isoforms that can be detected in cardiovascular, CNS and immune systems. Of the four subfamilies
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Development of a deep learning-based model to diagnose mixed-type gastric cancer accurately Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-07-21 Xinjie Ning, Ruide Liu, Nan Wang, Xuewen Xiao, Siqi Wu, Yu Wang, Chenju Yi, Yulong He, Dan Li, Hui Chen
Objective The accurate diagnosis of mixed-type gastric cancer from pathology images presents a formidable challenge for pathologists, given its intricate features and resemblance to other subtypes of gastric cancer. Artificial Intelligence has the potential to overcome this hurdle. This study aimed to leverage deep machine learning techniques to establish a precise and efficient diagnostic approach
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Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5 Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-07-13
The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of pre-mRNA splicing has been associated with several human diseases including cancer. The ubiquitin-like protein Hub1/UBL5 binds to the substrates non-covalently and promotes pre-mRNA splicing. Additionally, UBL5 promotes the common fragile sites stability and the Fanconi anemia pathway of DNA damage repair.
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Mitochondria and the cell cycle in budding yeast Int. J. Biochem. Cell Biol. (IF 4.0) Pub Date : 2023-07-06 Ana Cláudia Leite, Vítor Costa, Clara Pereira
As centers for energy production and essential biosynthetic activities, mitochondria are vital for cell growth and proliferation. Accumulating evidence suggests an integrated regulation of these organelles and the nuclear cell cycle in distinct organisms. In budding yeast, a well-established example of this coregulation is the coordinated movement and positional control of mitochondria during the different