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Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-17 Bojian Zhang, Junsheng Li, Chaofan Zeng, Chuming Tao, Qiheng He, Chenglong Liu, Zhiyao Zheng, Zhikang Zhao, Siqi Mou, Wei Sun, Jia Wang, Qian Zhang, Rong Wang, Yan Zhang, Peicong Ge, Dong Zhang
The study aimed to investigate the association between nonalcoholic fatty liver disease (NAFLD) and ischemic stroke events after revascularization in patients with Moyamoya disease (MMD). This study prospectively enrolled 275 MMD patients from September 2020 to December 2021. Patients with alcoholism and other liver diseases were excluded. NAFLD was confirmed by CT imaging or abdominal ultrasonography
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Triglyceride-glucose index in the prediction of new-onset arthritis in the general population aged over 45: the first longitudinal evidence from CHARLS Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-13 Yang Liu, Junjie Yao, Xiaona Xue, Yanan Lv, Sheng Guo, PeiDong Wei
Insulin resistance (IR) imposes a significant burden on inflammatory diseases, and the triglyceride-glucose (TyG) index, which is an easily accessible indicator for detecting IR, holds great application potential in predicting the risk of arthritis. The aim of this study is to analyze the association between the TyG index and the risk of new-onset arthritis in the common population aged over 45 using
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Causal association of obesity with epigenetic aging and telomere length: a bidirectional mendelian randomization study Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-12 Jixin Li, Wenru Wang, Zhenyu Yang, Linjie Qiu, Yan Ren, Dongling Wang, Meijie Li, Wenjie Li, Feng Gao, Jin Zhang
In observational studies, there exists an association between obesity and epigenetic age as well as telomere length. However, varying and partially conflicting outcomes have notably arisen from distinct studies on this topic. In the present study, two-way Mendelian randomization was used to identify potential causal associations between obesity and epigenetic age and telomeres. A genome-wide association
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Efficacy and safety of orlistat in male patients with overweight/obesity and hyperuricemia: results of a randomized, double-blind, placebo-controlled trial Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-11 Shuang Liu, Xiaojing Lin, Minghao Tao, Qi Chen, Hang Sun, Yali Han, Shaoling Yang, Yining Gao, Shen Qu, Haibing Chen
Obesity is associated with elevated serum uric acid (SUA) levels and frequent gout flares. Losing weight can reduce the SUA level and gout flares. The effect of orlistat on SUA levels and gout flares in patients with overweight/obesity and hyperuricemia (HUA) has not been extensively studied. This study investigated the effects of orlistat on SUA levels and gout flares compared to placebo in overweight
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Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-11 Heng Wang, Qinqin Tian, Ruijing Zhang, Qiujing Du, Jie Hu, Tingting Gao, Siqi Gao, Keyi Fan, Xing Cheng, Sheng Yan, Guoping Zheng, Honglin Dong
Atherosclerosis (AS) is a persistent inflammatory condition triggered and exacerbated by several factors including lipid accumulation, endothelial dysfunction and macrophages infiltration. Nobiletin (NOB) has been reported to alleviate atherosclerosis; however, the underlying mechanism remains incompletely understood. This study involved comprehensive bioinformatic analysis, including multidatabase
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Remnant cholesterol is correlated with retinal vascular morphology and diabetic retinopathy in type 2 diabetes mellitus: a cross-sectional study Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-11 Shuli Chen, Yi Xu, Bo Chen, Senlin Lin, Lina Lu, Minna Cheng, Yuheng Wang, Qinping Yang, Saiguang Ling, Dengji Zhou, Yan Shi, Haidong Zou, Yingyan Ma
The association between remnant cholesterol (RC) and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) remains unclear. Morphological changes in retinal vessels have been reported to predict vascular complications of diabetes, including DR. This cross-sectional study included 6535 individuals with T2DM. The RC value was calculated using the recognized formula. The retinal vascular parameters
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Effects of sustained viral response on lipid in Hepatitis C: a systematic review and meta-analysis Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-09 Tingting Mei, Xiaojie Huang, Shan Tang, Menglu Liu, Wenyan Zhang, Haibin Yu
Direct-acting Antiviral Agents (DAAs) influence serum lipids of patients with Hepatitis C virus (HCV). This paper presents an analysis of the relevant literature to investigate the effects of DAAs in treating hepatitis C to achieve a sustained viral response (SVR) on lipid parameters. PubMed,Web of science, Embase and Central databases were searched, with a deadline of September 2023. Studies on the
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Associations between dietary fatty acids intake and abdominal aortic calcification: a national population-based study Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-09 Yan Xiao, Yingping Quan
Abdominal aortic calcification (AAC) is a crucial indicator of cardiovascular health. This study aims investigates the associations between dietary fatty acid intake and AAC. In this study, a cross-sectional assessment was performed on a group of 2,897 individuals aged 40 and above, utilizing data from the NHANES. The focus was on examining dietary consumption of various fatty acids, including Saturated
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Dyslipidemia versus obesity as predictors of ischemic stroke prognosis: a multi-center study in China Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-09 Hang Ruan, Xiao Ran, Shu-sheng Li, Qin Zhang
This multicenter observational study aimed to determine whether dyslipidemia or obesity contributes more significantly to unfavorable clinical outcomes in patients experiencing a first-ever ischemic stroke (IS). The study employed a machine learning predictive model to investigate associations among body mass index (BMI), body fat percentage (BFP), high-density lipoprotein (HDL), triglycerides (TG)
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Relative importance of triglyceride glucose index combined with body mass index in predicting recovery from prediabetic state to normal fasting glucose: a cohort analysis based on a Chinese physical examination population Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-08 Hongyi Yang, Maobin Kuang, Jiajun Qiu, Shiming He, Changhui Yu, Guotai Sheng, Yang Zou
Prediabetes is a high-risk state for diabetes, and numerous studies have shown that the body mass index (BMI) and triglyceride-glucose (TyG) index play significant roles in risk prediction for blood glucose metabolism. This study aims to evaluate the relative importance of BMI combination with TyG index (TyG-BMI) in predicting the recovery from prediabetic status to normal blood glucose levels. A total
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Analysis of the clinical profile and treatment efficiency of hyperlipidemic acute pancreatitis Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-08 Weidong Zhou, Qinfu Liu, Zhaojun Wang, Liying Yao, Jian Chen, Xiaojun Yang
The incidence of hyperlipidemic acute pancreatitis (HLAP) has been increasing annually. However, population-based morbidity assessments need to be updated. Early, rapid, and effective lipid-lowering may minimize pancreatic injury and improve clinical prognosis. It is essential to choose the proper treatment. However, treatment options for HLAP are controversial, and there is no uniform treatment protocol
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Impact of chronic psychological stress on platelet membrane fatty acid composition in a rat model of type 1 diabetes Mellitus Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-08 Inga Bikulčienė, Justinas Baleišis, Eglė Mazgelytė, Romualdas Rudys, Rūta Vosyliūtė, Renata Šimkūnaitė-Rizgelienė, Arvydas Kaminskas, Dovilė Karčiauskaitė
Chronic stress and diabetes mellitus are highly associated with oxidative stress and inflammation, resulting in cell membrane disruption and platelet activity. This study aims to evaluate the impact of chronic psychological stress on the composition of the platelet phospholipid membrane and platelet activation in type 1 diabetes mellitus (T1DM). We enrolled 35 mature healthy female Wistar rats and
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The effects of restraint stress on ceramide metabolism disorders in the rat liver: the role of CerS6 in hepatocyte injury Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-02 Yichang Liu, Zhaoling Sun, Qiuli Sun, Li Wang, Chuan Wang, Yingmin Li, Chunling Ma, Weibo Shi, Guozhong Zhang, Yiming Dong, Xiaojing Zhang, Bin Cong
Stress is implicated in various pathological conditions leading to liver injury. Existing evidence suggests that excessive stress can induce mitochondrial damage in hepatocytes, yet the underlying mechanism remains unclear. Ceramide synthase 6 (CerS6)-derived C16:0 ceramide is recognised as a lipotoxic substance capable of causing mitochondrial damage. However, the role of CerS6 in stress has received
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Associations of dietary iron intake with cardiovascular disease risk and dyslipidemia among Chinese adults Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-02 Min Cui, Hao Wu, Hanmo Zhang, Liping Wei, Xin Qi
Whether iron intake can affect cardiovascular disease (CVD) and dyslipidemia is controversial. However, few studies have focused on reducing the risk of CVD in people at risk for dyslipidemia. This study explored the linear relationship and possible nonlinear relationship between CVD and dyslipidemia. Dietary data were obtained from the China Health and Nutrition Survey between 2004 and 2015. The survey
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The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-01 Yu Gao, Miyuan Wang, Ruiting Wang, Jinchi Jiang, Yueyao Hu, Wei Wang, Yong Wang, Haijing Li
Cardiovascular disease (CVD) is associated with inflammation and abnormal lipid metabolism. However, a single inflammatory index or a single lipid index cannot accurately predict the prognosis of CVD independently because it is prone to be affected by various confounding factors. This population-based cohort study included 6,554 participants from the China Health and Retirement Longitudinal Study (CHARLS)
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Association between biomarkers of inflammation and dyslipidemia in drug resistant tuberculosis in Uganda Lipids Health Dis. (IF 4.5) Pub Date : 2024-03-01 Joseph Baruch Baluku, Robinah Nalwanga, Andrew Kazibwe, Ronald Olum, Edwin Nuwagira, Nathan Mugenyi, Frank Mulindwa, Felix Bongomin
Active tuberculosis (TB) significantly increases the risk of cardiovascular disease, but the underlying mechanisms remain unclear. This study aimed to investigate the association between inflammation biomarkers and dyslipidemia in patients with drug-resistant TB (DR-TB). This was a secondary analysis of data from a cross-sectional multi-center study in Uganda conducted 2021. Participants underwent
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A mediation analysis of the role of total free fatty acids on pertinence of gut microbiota composition and cognitive function in late life depression Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-29 Yan Chen, Jiarong Li, Dansheng Le, Yuhan Zhang, Zhengluan Liao
Extensive evidence demonstrates correlations among gut microbiota, lipid metabolism and cognitive function. However, there is still a lack of researches in the field of late-life depression (LLD). This research targeted at investigating the relationship among gut microbiota, lipid metabolism indexes, such as total free fatty acids (FFAs), and cognitive functions in LLD. Twenty-nine LLD patients from
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Effect of sacubitril/valsartan on lipid metabolism in patients with chronic kidney disease combined with chronic heart failure: a retrospective study Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-28 Manzhi Li, Ao Zhong, Yifan Tang, Jinnuo Yu, Mengmeng Wu, Karthick Kumaran Munisamy Selvam, Dong Sun
Dyslipidemia is significantly more common in those with concurrent chronic kidney disease (CKD) and chronic heart failure (CHF). Sacubitril/valsartan has showcased its influence on both cardiac and renal functions, extending its influence to the modulation of lipid metabolism pathways. This study aimed to examine how sacubitril/valsartan affects lipid metabolism within the context of CKD and CHF. This
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In-hospital and mid-term follow-up of low-density lipoprotein cholesterol and target-goal attainment among patients with acute cerebral infarction: a retrospective study Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-28 Zhong Chen, Shijia Jin, Yifan Zhang
To investigate the baseline and six-month follow-up data of the main lipid indices as well as low-density lipoprotein cholesterol (LDL-C) target goal attainment in accordance with the current guidelines among patients with acute cerebral infarction (ACI). One thousand ninety-nine patients were consecutively enrolled from January 2021 to December 2022 and divided into ACI, old cerebral infarction (OCI)
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Appraising associations between signature lipidomic biomarkers and digestive system cancer risk: novel evidences from a prospective cohort study of UK Biobank and Mendelian randomization analyses Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-28 Yuanlin Sun, Donghui Cao, Yang Zhang, Yanhua Wu, Zhifang Jia, Yingnan Cui, Dongming Li, Xueyuan Cao, Jing Jiang
The roles of serum lipids on digestive system cancer (DSC) risk were still inconclusive. In this study, we systematically assessed indicative effects of signature lipidomic biomarkers (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG)) on DSC (oesophagus, stomach, colorectal, liver, gallbladder, and pancreas cancers) risk. HDL-C, LDL-C
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Correction: The association between triglyceride glucose index and arthritis: a population-based study Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-27 Yuxin Yan, Liyu Zhou, Rui La, Ming Jiang, Dinghua Jiang, Lixin Huang, Wu Xu, Qian Wu
Correction: Lipids in Health and Disease 22, 132 (2023) https://doi.org/10.1186/s12944-023-01899-9 Following publication of the original article [1], the authors have identified errors in Introduction section and Table 5. The corrections are as follows: 1. In the Introduction section, the original sentence reads: “Arthritis, a complex and widespread medical condition, is characterized by inflammation
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Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-27 Emilie Wong Chong, France-Hélène Joncas, Pierre Douville, Dimcho Bachvarov, Caroline Diorio, Frédéric Calon, Ann-Charlotte Bergeron, Jonatan Blais, Shuk On Annie Leung, Nabil Georges Seidah, Anne Gangloff
Cancer cells need constant supplies of lipids to survive and grow. Lipid dependence has been observed in various types of cancer, including high-grade serous ovarian carcinomas (HGSOC), which is a lethal form of gynecological malignancy. ANGPTL3, PCSK9, and Apo CIII are pivotal lipid-modulating factors, and therapeutic antibodies have been developed against each one (Evinacumab, Evolocumab and Volanesorsen
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Bidirectional two-sample mendelian randomization analysis identifies causal associations of MRI-based cortical thickness and surface area relation to NAFLD Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-23 Zun Mao, Zhi-xiang Gao, Tong Ji, Sheng Huan, Guo-ping Yin, Long Chen
Non-alcoholic fatty liver disease (NAFLD) patients have exhibited extra-hepatic neurological changes, but the causes and mechanisms remain unclear. This study investigates the causal effect of NAFLD on cortical structure through bidirectional two-sample Mendelian randomization analysis. Genetic data from 778,614 European individuals across four NAFLD studies were used to determine genetically predicted
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Identification of risk factors and development of a predictive model for chronic kidney disease in patients with obesity: a four-year cohort study Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-22 Haixia Zhang, Yue Zhang, Wenxing Gao, Yiming Mu
The sneaky onset and dismal prognosis of chronic kidney disease (CKD) make it an important public health issue. Obesity-related kidney illness has garnered more attention in recent times. Establishing and validating a risk prediction model for chronic renal illness in overweight or obese adults was the goal of this investigation. Data from the China Health and Retirement Longitudinal Study were used
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HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-22 Siobhán O.’ Sullivan, Cynthia Al Hageh, Andreas Henschel, Stephanie Chacar, Antoine Abchee, Pierre Zalloua, Moni Nader
Type 2 Diabetes (T2D) is influenced by genetic, environmental, and ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to examine both clinical and genetic factors of T2D in older adults. A total of 2,909 genotyped patients were enrolled in this study. Genome Wide Association Study was conducted, comparing T2D patients to non-diabetic older adults aged ≥ 60, ≥ 65, or ≥ 70
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Sexual dysfunction in patients with diabetes: association between remnant cholesterol and erectile dysfunction Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-22 Ke Huang, Shan Yin, Yunfei Xiao, Jiahao Wang, Jianwei Cui, Jia Wang, Yunjin Bai
Erectile dysfunction (ED) is closely associated with dyslipidemia; however, it is yet unknown how ED and remnant cholesterol (RC) are related. As such, this research sought to explore the correlation between RC and ED among individuals with diagnosed with diabetes. This cross-sectional study used information from 215 males from National Health and Nutrition Examination Survey (NHANES) from 2001 to
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Establishing non-fasting reference values for plasma lipids levels based on age, sex, and puberty stage in a French-Canadian pediatric population Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-22 Sophie Bouhour, Rosalie Plantefève, Virginie Gillet, Armita Abolghasemi, Fatima Zahra Bouchouirab, Andrea A. Baccarelli, Larissa Takser, Artuela Çaku
Dyslipidemias, including familial hypercholesterolemia (FH), are a significant risk factor for cardiovascular diseases. FH is a genetic disorder resulting in elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased probability of early cardiovascular disorders. Heterozygous familial hypercholesterolemia (HeFH) is the most common form, affecting approximately 1 in 250 individuals
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Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-22 Rupeng Wang, Ce Chen, Guiyu Xu, Zening Jin
The Triglyceride glucose-body mass index (TyG-BMI) and hemoglobin glycation index (HGI) are well-established surrogate markers for insulin resistance. Nevertheless, the extent to which these markers offer additive predictive value for heart failure (HF) prevalence in hypertensive populations, and their predictive utility across various diabetic statuses, remains to be clarified. Consequently, this
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Topical rhubarb charcoal-crosslinked chitosan/silk fibroin sponge scaffold for the repair of diabetic ulcers improves hepatic lipid deposition in db/db mice via the AMPK signalling pathway Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-20 Qi Tan, Qifeng He, Ze Peng, Xin Zeng, Yuzhe Liu, Dong Li, Shang Wang, Jianwei Wang
Type 2 diabetes mellitus (T2DM) is closely linked to metabolic syndrome, characterised by insulin resistance, hyperglycaemia, abnormal lipid metabolism, and chronic inflammation. Diabetic ulcers (DUs) comprise consequential complications that arise as a result of T2DM. To investigate, db/db mice were used for the disease model. The findings demonstrated that a scaffold made from a combination of rhubarb
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Adiponectin protects against myocardial ischemia–reperfusion injury: a systematic review and meta-analysis of preclinical animal studies Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-17 Hongyi Yue, Qunhui Zhang, Senhao Chang, Xinjie Zhao, Mengjie Wang, Wenhua Li
Myocardial ischemia–reperfusion injury (MIRI) is widespread in the treatment of ischemic heart disease, and its treatment options are currently limited. Adiponectin (APN) is an adipocytokine with cardioprotective properties; however, the mechanisms of APN in MIRI are unclear. Therefore, based on preclinical (animal model) evidence, the cardioprotective effects of APN and the underlying mechanisms were
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Phosphorylation: new star of pathogenesis and treatment in steatotic liver disease Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-17 Tiansu Lv, Yan Lou, Qianhua Yan, Lijuan Nie, Zhe Cheng, Xiqiao Zhou
Steatotic liver disease poses a serious threat to human health and has emerged as one of the most significant burdens of chronic liver disease worldwide. Currently, the research mechanism is not clear, and there is no specific targeted drug for direct treatment. Phosphorylation is widely regarded as the most common type of protein modification, closely linked to steatotic liver disease in previous
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TRP channels associated with macrophages as targets for the treatment of obese asthma Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-17 Wenzhao Zhu, Dinxi Bai, Wenting Ji, Jing Gao
Globally, obesity and asthma pose significant health challenges, with obesity being a key factor influencing asthma. Despite this, effective treatments for obese asthma, a distinct phenotype, remain elusive. Since the discovery of transient receptor potential (TRP) channels in 1969, their value as therapeutic targets for various diseases has been acknowledged. TRP channels, present in adipose tissue
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A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-16 Casimiro Castillejo-López, José Ramón Bárcenas-Walls, Marco Cavalli, Anders Larsson, Claes Wadelius
Genome-wide association studies (GWAS) have identified genetic variants linked to fat metabolism and related traits, but rarely pinpoint causative variants. This limitation arises from GWAS not considering functional implications of noncoding variants that can affect transcription factor binding and potentially regulate gene expression. The aim of this study is to investigate a candidate noncoding
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Assessment of whole-body and regional body fat using abdominal quantitative computed tomography in Chinese women and men Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-14 Jinci Mai, Qiulian Wu, Huanhua Wu, Chunyuan Zeng, Yingxin Li, Jingjie Shang, Biao Wu, Qijun Cai, Junbi Du, Jian Gong
Being overweight or obese has become a serious public health concern, and accurate assessment of body composition is particularly important. More precise indicators of body fat composition include visceral adipose tissue (VAT) mass and total body fat percentage (TBF%). Study objectives included examining the relationships between abdominal fat mass, measured by quantitative computed tomography (QCT)
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Joint association of physical activity and diet quality with dyslipidemia: a cross-sectional study in Western China Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-10 Munire Mutalifu, Qian Zhao, Ying Wang, Xieyire Hamulati, Yu-Shan Wang, Lei Deng, Niyaziaili Adili, Fen Liu, Yi-Ning Yang, Xiao-Mei Li
This study aims to investigate the prevalence of dyslipidemia and assess the joint association of physical activity (PA) and diet quality on dyslipidemia risk in urban areas of Xinjiang. Conducted from July 2019 to September 2021 in Xinjiang, China, this cross-sectional study involved 11,855 participants (mean age 47.1 ± 9.4 years, 53.1% male). Standard methods were used to measure plasma cholesterol
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Associations of the triglyceride-glucose index and remnant cholesterol with coronary artery disease: a retrospective study Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-10 Xiaosheng Wu, Weiping Qiu, Houlin He, Guojun Zhao, Jianling Liu
Remnant cholesterol (RC) represents a low-cost and readily measured lipid index that contributes significantly to residual cardiovascular disease risk. The triglyceride-glucose (TyG) index exhibits a significant correlation with cardiovascular disease occurrence. However, RC and the TyG index have rarely been examined for their potentials in predicting coronary artery disease (CAD). Accordingly, the
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The pathogenic mutations of APOA5 in Chinese patients with hyperlipidemic acute pancreatitis Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-08 Yuxin Liu, Si Dai, Shuqi Qin, Jing Zhou, Zhendan Wang, Guojian Yin
To study the role of gene mutations in the development of severe hypertriglyceridemia (HTG) in patients with hyperlipidemic acute pancreatitis (HLAP), especially different apolipoprotein A5 (APOA5) mutations. Whole-exome sequencing was performed on 163 patients with HLAP and 30 patients with biliary acute pancreatitis (BAP). The pathogenicity of mutations was then assessed by combining clinical information
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An improved method for estimating low LDL-C based on the enhanced Sampson-NIH equation Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-08 Tatiana C. Coverdell, Maureen Sampson, Rafael Zubirán, Anna Wolska, Leslie J. Donato, Jeff W. Meeusen, Allan S. Jaffe, Alan T. Remaley
The accurate measurement of Low-density lipoprotein cholesterol (LDL-C) is critical in the decision to utilize the new lipid-lowering therapies like PCSK9-inhibitors (PCSK9i) for high-risk cardiovascular disease patients that do not achieve sufficiently low LDL-C on statin therapy. To improve the estimation of low LDL-C by developing a new equation that includes apolipoprotein B (apoB) as an independent
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Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-08 Pengdi Liu, Jin Liu, Yafei Zhang, Xin Xing, Le Zhou, Jianqiang Qu, Xianxia Yan
Lewy body dementia (LBD) ranks second among prevalent neurodegenerative dementias. Previous studies have revealed associations of serum lipid measures with several neurodegenerative diseases. Nevertheless, the potential connection between serum lipids and LBD remains undetermined. In this study, Mendelian randomization (MR) analyses were carried out to assess the causal relationships of several serum
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What are the common downstream molecular events between alcoholic and nonalcoholic fatty liver? Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-08 Giovanni Tarantino, Vincenzo Citro
Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is not without consequences. In fact, hepatic steatosis contributes to the progression toward liver fibrosis. There are two main types of fatty liver disease, alcoholic fatty liver disease (AFLD) and nonalcoholic fatty liver disease (NAFLD). Although AFLD
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Association between cardiometabolic index and controlled attenuation parameter in U.S. adults with NAFLD: findings from NHANES (2017–2020) Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-07 Wen-feng Xi, Ai-ming Yang
Cardiometabolic index (CMI), a novel indicator that combines abdominal obesity and lipid levels, has been confirmed to correlate with non-alcoholic fatty liver disease (NAFLD). However, limited research has been conducted on the relationship between CMI and controlled attenuation parameter (CAP), a parameter measured by transient elastography and reflecting the extent of fat accumulation in the liver
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The causal relationship between human blood metabolites and the risk of visceral obesity: a mendelian randomization analysis Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-07 Zhaoxiang Wang, Qichao Yang
We aimed to explore the causal relationship between blood metabolites and the risk of visceral obesity, as measured by visceral adipose tissue (VAT). Summary statistics for 486 blood metabolites and total, as well as sex-stratified, MRI-derived VAT measurements, adjusted for body mass index (BMI) and height, were collected from previous genome-wide association studies (GWAS). A two-sample Mendelian
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The association between remnant cholesterol and rheumatoid arthritis: insights from a large population study Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-07 Yuxin Yan, Rui La, Ming Jiang, Wu Xu, Dinghua Jiang, Shenghao Wang, Lixin Huang, Qian Wu
While lipid metabolism disorder is widely acknowledged as a contributing factor to inflammation, the association between remnant cholesterol (RC), which indicates lipid metabolism, and rheumatoid arthritis (RA) has not been investigated. Accordingly, this study evaluated whether RC is associated with RA disease events. Data were collected and specifically extracted from the National Health and Nutrition
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Dysregulated lipid metabolism is associated with kidney allograft fibrosis Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-03 Linjie Peng, Chang Wang, Shuangjin Yu, Qihao Li, Guobin Wu, Weijie Lai, Jianliang Min, Guodong Chen
Interstitial fibrosis and tubular atrophy (IF/TA), a histologic feature of kidney allograft destruction, is linked to decreased allograft survival. The role of lipid metabolism is well-acknowledged in the area of chronic kidney diseases; however, its role in kidney allograft fibrosis is still unclarified. In this study, how lipid metabolism contributes to kidney allografts fibrosis was examined. A
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LDLR gene rearrangements in Czech FH patients likely arise from one mutational event Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-02 Kateřina Konečná, Petra Zapletalová, Tomáš Freiberger, Lukáš Tichý
Large deletions and duplications within the low-density lipoprotein receptor (LDLR) gene make up approximately 10% of LDLR pathogenic variants found in Czech patients with familial hypercholesterolemia. The goal of this study was to test the hypothesis that all probands with each rearrangement share identical breakpoints inherited from a common ancestor and to determine the role of Alu repetitive elements
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Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy Lipids Health Dis. (IF 4.5) Pub Date : 2024-02-01 Yuting Wu, Xi Pu, Xu Wang, Min Xu
Lipid metabolism in cancer cells has garnered increasing attention in recent decades. Cancer cells thrive in hypoxic conditions, nutrient deficiency, and oxidative stress and cannot be separated from alterations in lipid metabolism. Therefore, cancer cells exhibit increased lipid metabolism, lipid uptake, lipogenesis and storage to adapt to a progressively challenging environment, which contribute
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Association of hysterectomy with nonalcoholic fatty liver disease among US women Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-31 Shuanghong Jin, Shaoxun Li, Peipei Fang, Chenwei Pan, Shanshan Huang
A postmenopausal rise in the rates of nonalcoholic fatty liver disease (NAFLD) has been reported in women. This study thus sought to further probe the association of hysterectomy with NAFLD. The data utilized in this investigation were attained from the 2017-March 2020 cycle of the National Health and Nutrition Examination Survey (NHANES), reflecting a strategic utilization of comprehensive health
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Predicting the 10-year incidence of dyslipidemia based on novel anthropometric indices, using data mining Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-31 Alireza Takhttavous, Maryam Saberi-Karimian, Somayeh Ghiasi Hafezi, Habibollah Esmaily, Marzieh Hosseini, Gordon A. Ferns, Elham Amirfakhrian, Mark Ghamsary, Majid Ghayour-Mobarhan, Maryam Alinezhad-Namaghi
The aim was to establish a 10-year dyslipidemia incidence model, investigating novel anthropometric indices using exploratory regression and data mining. This data mining study was conducted on people who were diagnosed with dyslipidemia in phase 2 (n = 1097) of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study, who were compared with healthy people in this phase (n = 679). The association
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Association of saturated fatty acids with cancer risk: a systematic review and meta-analysis Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-30 Jin Mei, Meiyu Qian, Yanting Hou, Maodi Liang, Yao Chen, Cuizhe Wang, Jun Zhang
Extensive research has explored the link between saturated fatty acids (SFAs) and cardiovascular diseases, alongside other biological dysfunctions. Yet, their association with cancer risk remains a topic of debate among scholars. The present study aimed to elucidate this association through a robust meta-analysis. PubMed, Embase, Cochrane Library, and Web of Science databases were searched systematically
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Correlations between genetically predicted lipid-lowering drug targets and inflammatory bowel disease Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-29 Kuiyuan Huang, Shenan Huang, Ming Xiong
Millions of individuals globally suffer from Inflammatory bowel diseases (IBDs). There is a dearth of large population-based investigations on lipid metabolism and IBDs, and it is unclear whether lipid-lowering drugs target IBDs causally. Consequently, the aim of this study was to investigate the effects of lipid-lowering medication targets on the occurrence and progression of IBDs. Among the more
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Differences between repeated lipid profile measurements in a tertiary hospital over a short time period Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-27 Or Porat, Marriele Kaplan, Smadar Atlibenkin, Dalia Hasson-Gilad, Amir Karban, Ronen Zalts
Measurement of the plasma lipid profile, mainly low-density lipoprotein cholesterol (LDL-C), is widely used in the management of hospitalized patients as part of their cardiometabolic risk assessment. In common practice, LDL-C is calculated indirectly by the Friedewald equation. For many years, fasting of 8–14 h is needed to obtain an accurate lipid profile measurement, although recent guidelines do
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Triglyceride-glucose index is a risk factor for breast cancer in China: a cross-sectional study Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-26 Jinghua Zhang, Binbin Yin, Ya Xi, Yongying Bai
This research delved into the association between the risk of the Chinese population suffering from breast cancer (BC) and the triglyceride-glucose (TyG) index. A total of 2,111 sufferers with benign breast disease (BBD) and 477 sufferers with BC were enrolled, and their TyG index was measured. Participants with varying TyG index values were categorized into quartiles. Logistic regression analysis
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Yam Gruel alone and in combination with metformin regulates hepatic lipid metabolism disorders in a diabetic rat model by activating the AMPK/ACC/CPT-1 pathway Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-25 Yanling Dai, Chen Qiu, Diandian Zhang, Mianli Li, Weinan Liu
As independent and correctable risk factors, disturbances in lipid metabolism are significantly associated with type 2 diabetes mellitus (T2DM). This research investigated the mechanism underlying the lipid-regulating effects of Yam Gruel in diabetic rats. First, rats in the control group were given a normal diet, and a diabetic rat model was established via the consumption of a diet that was rich
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Association between high-density lipoprotein cholesterol and lumbar bone mineral density in Chinese: a large cross-sectional study Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-24 Yongbing Sun, Xin Qi, Xuan Wang, Xinbei Lin, Yang Zhou, Yawei Du, Ao Liu, Xue Lv, Jing Zhou, Zhonglin Li, Xiaoling Wu, Zhi Zou, Michael Zhang, Jiadong Zhu, Feifei Shang, Yongli Li, Hao Li
The association between lipid and bone metabolism, particularly the role of high-density lipoprotein cholesterol (HDL-C) in regulating bone mineral density (BMD), is of significant interest. Despite numerous studies, findings on this relationship remain inconclusive, especially since evidence from large, sexually diverse Chinese populations is sparse. This study, therefore, investigates the correlation
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Adipokines in atopic dermatitis: the link between obesity and atopic dermatitis Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-23 Shiyun Zhang, Bingjie Zhang, Yuehua Liu, Li Li
Atopic dermatitis (AD) is a chronic skin condition with intense pruritus, eczema, and dry skin. The recurrent intense pruritus and numerous complications in patients with AD can profoundly affect their quality of life. Obesity is one of its comorbidities that has been confirmed to be the hazard factor of AD and also worsen its severity. Nevertheless, the specific mechanisms that explain the connection
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Dietary patterns derived by reduced rank regression are associated with lipid disorders among Korean adults: a cross-sectional analysis Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-23 Hyun Ah Kim, Hye Ran Shin, SuJin Song
Lipid disorders are a potent risk factor for cardiovascular diseases. Moreover, the intake of dietary fatty acids has been closely related to blood lipid levels. Therefore, this cross-sectional study examined the associations between dietary patterns related to fatty acid intake and lipid disorders in Korean adults. From the 2013–2019 Korea National Health and Nutrition Examination Surveys data, 8399
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Residual risk of cardiovascular complications in statin-using patients with type 2 diabetes: the Taiwan Diabetes Registry Study Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-23 Chin-Sung Kuo, Nai-Rong Kuo, Yun-Kai Yeh, Yau-Jiunn Lee, Lee-Ming Chuang, Hua-Fen Chen, Ching-Chu Chen, Chun-Chuan Lee, Chih-Cheng Hsu, Hung-Yuan Li, Horng-Yih Ou, Chii-Min Hwu
The residual risks of atherosclerotic cardiovascular disease in statin-treated patients with diabetes remain unclear. This study was conducted to identify factors associated with these residual risks in patients with no prior vascular event. Data on 683 statin-using patients with type 2 diabetes mellitus (T2DM) from the Taiwan Diabetes Registry were used in this study. Patients aged < 25 or > 65 years
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Machine learning-based integration identifies the ferroptosis hub genes in nonalcoholic steatohepatitis Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-23 Longfei Dai, Wenkang Yuan, Renao Jiang, Zhicheng Zhan, Liangliang Zhang, Xinjian Xu, Yuyang Qian, Wenqi Yang, Zhen Zhang
Ferroptosis, is characterized by lipid peroxidation of fatty acids in the presence of iron ions, which leads to cell apoptosis. This leads to the disruption of metabolic pathways, ultimately resulting in liver dysfunction. Although ferroptosis is linked to nonalcoholic steatohepatitis (NASH), understanding the key ferroptosis-related genes (FRGs) involved in NASH remains incomplete. NASH may be targeted
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Predictive value of lipoprotein(a) for left atrial thrombus or spontaneous echo contrast in non-valvular atrial fibrillation patients with low CHA2DS2-VASc scores: a cross-sectional study Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-22 Kamila Kamili, Tingting Zheng, Chaodi Luo, Xuan Wang, Gang Tian
Current guidelines are debated when it comes to starting anticoagulant therapy in patients with non-valvular atrial fibrillation (NVAF) and low CHA2DS2-VASc scores (1–2 in women and 0–1 in men). However, these individuals still have a high likelihood of developing left atrial thrombus/spontaneous echo contrast (LAT/SEC) and experiencing subsequent thromboembolism. Recent research has demonstrated that
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High lipoprotein(a) concentration is associated with moyamoya disease Lipids Health Dis. (IF 4.5) Pub Date : 2024-01-22 Xinyue Chen, Chenxin Song, Xianrun Ma, Junjie Tao, Lijuan Hu, Yuan Xu, Yingping Yi, Xinlei Yang, Long Jiang
Moyamoya disease (MMD) has attracted the attention of scholars because of its rarity and unknown etiology. Data for this study were sourced from the Second Affiliated Hospital of Nanchang University. Regression analyses were conducted to examine the association in Lipoprotein [Lp(a)] and MMD. R and IBM SPSS were conducted. A cohort comprising 1012 MMD patients and 2024 controls was established through