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A cohort study on risk factors of high-density lipoprotein cholesterol hypolipidemia among urban Chinese adults Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-22 Fang Tang; Jian Wang; Stephen Nicholas; Dongfu Qian; Rugang Liu
High-density lipoprotein cholesterol (HDL-C) hypolipidemia, a major type of dyslipidemia, has been associated with many kinds of diseases, such as stroke, coronary heart disease, obesity and diabetes, and has displayed an increasing prevalence in China. This study explores the risk factors of HDL-C hypolipidemia and makes recommendations for controlling and preventing HDL-C hypolipidemia and the diseases
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Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-21 Jianjun Jiang; Yining Shi; Jiyu Cao; Youjin Lu; Gengyun Sun; Jin Yang
This study aimed to explore the effects of ceramide (Cer) on NLRP3 inflammasome activation and their underlying mechanisms. Lipopolysaccharide (LPS)/adenosine triphosphate (ATP)-induced NLRP3 inflammasome activation in J774A.1 cells and THP-1 macrophages was used as an in vitro model of inflammation. Western blotting and real-time PCR (RT-PCR) were used to detect the protein and mRNA levels, respectively
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A meta-analysis of HDL cholesterol efflux capacity and concentration in patients with rheumatoid arthritis Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-21 Binbin Xie; Jiang He; Yong Liu; Ting Liu; Chaoqun Liu
Poor cholesterol efflux capacity (CEC) has been proposed to be an independent risk factor for cardiovascular diseases. However, current evidence is inconsistent, especially in rheumatoid arthritis (RA) patients. This meta-analysis aims to identify whether CEC is impaired or altered by drug therapy in RA. The PubMed/MEDLINE, Embase, Cochrane Library and ClinicalTrials.gov databases were browsed to identify
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Pemafibrate decreases triglycerides and small, dense LDL, but increases LDL-C depending on baseline triglycerides and LDL-C in type 2 diabetes patients with hypertriglyceridemia: an observational study Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-20 Ichiro Komiya; Akira Yamamoto; Suguru Sunakawa; Tamio Wakugami
Pemafibrate, a selective PPARα modulator, has the beneficial effects on serum triglycerides (TGs) and very low density lipoprotein (VLDL), especially in patients with diabetes mellitus or metabolic syndrome. However, its effect on the low density lipoprotein cholesterol (LDL-C) levels is still undefined. LDL-C increased in some cases together with a decrease in TGs, and the profile of lipids, especially
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Metabolic profiling reveals interleukin-17A monoclonal antibody treatment ameliorate lipids metabolism with the potentiality to reduce cardiovascular risk in psoriasis patients Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-18 Han Cao; Shengmin Su; Qi Yang; Yunchen Le; Lihong Chen; Mengyan Hu; Xiaoyu Guo; Jie Zheng; Xia Li; Yunqiu Yu
Psoriasis is a common chronic inflammatory skin disease associated with overproduction of interleukin-17A (IL-17A). IL-17A monoclonal antibodies (mAbs) have shown clinical efficacy in psoriasis patients. Although a series of different overlapping mechanisms have been found to establish a link between psoriasis and cardiovascular diseases, the underlying mechanisms of the two types of diseases and the
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Identification of lipidomic profiles associated with drug-resistant prostate cancer cells Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-17 Lishann M. Ingram; Morgan C. Finnerty; Maryam Mansoura; Chau-Wen Chou; Brian S. Cummings
The association of circulating lipids with clinical outcomes of drug-resistant castration-resistant prostate cancer (DR-CRPC) is not fully understood. While it is known that increases in select lipids correlate to decreased survival, neither the mechanisms mediating these alterations nor the correlation of resistance to drug treatments is well characterized. This gap-in-knowledge was addressed using
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Familial hypertriglyceridemia: an entity with distinguishable features from other causes of hypertriglyceridemia Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-15 Ivette Cruz-Bautista; Alicia Huerta-Chagoya; Hortensia Moreno-Macías; Rosario Rodríguez-Guillén; María Luisa Ordóñez-Sánchez; Yayoi Segura-Kato; Roopa Mehta; Paloma Almeda-Valdés; Lizeth Gómez-Munguía; Ximena Ruiz-De Chávez; Ximena Rosas-Flota; Arali Andrade-Amado; Bárbara Bernal-Barroeta; María Guadalupe López-Carrasco; Luz Elizabeth Guillén-Pineda; Angelina López-Estrada; Daniel Elías-López; Alexandro
Familial hypertriglyceridemia (FHTG) is a partially characterized primary dyslipidemia which is frequently confused with other forms hypertriglyceridemia. The aim of this work is to search for specific features that can help physicians recognize this disease. This study included 84 FHTG cases, 728 subjects with common mild-to-moderate hypertriglyceridemia (CHTG) and 609 normotriglyceridemic controls
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Triglycerides to high-density lipoprotein cholesterol ratio is superior to triglycerides and other lipid ratios as an indicator of increased urinary albumin-to-creatinine ratio in the general population of China: a cross-sectional study Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-15 Jing Xue; Yuxia Wang; Bing Li; Songyan Yu; Anping Wang; Weiqing Wang; Zhengnan Gao; Xulei Tang; Li Yan; Qin Wan; Guijun Qin; Lulu Chen; Guang Ning; Yiming Mu
Dyslipidemia contributes to the pathogenesis of renal dysfunction. Previous research demonstrated that triglycerides (TG), instead of other individual lipid indexes, has a significant link with elevated urinary albumin-to-creatinine ratio (UACR). However, it is unclear whether lipid ratios are superior indicators of increased UACR compared with TG. This research is to determine whether there are close
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Lipoprotein-associated phospholipase A2 levels, endothelial dysfunction and arterial stiffness in patients with stable coronary artery disease Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-14 Konstantinos Mourouzis; Gerasimos Siasos; Evangelos Oikonomou; Marina Zaromitidou; Vicky Tsigkou; Alexis Antonopoulos; Evanthia Bletsa; Panagiota Stampouloglou; Konstantinos Vlasis; Manolis Vavuranakis; Dimitris Tousoulis
Lipoprotein-associated Phospholipase A2 (Lp-PLA2), can exert proinflammatory as well as proatherogenic properties on the vascular wall. The current study sought to evaluate the influence of high Lp-PLA2 levels on indices of arterial wall properties in patients with stable coronary artery disease (CAD). Three hundred seventy-four consecutive patients with stable CAD (mean age 61 ± 11 years, 89% males)
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Genetic factors increase the identification efficiency of predictive models for dyslipidaemia: a prospective cohort study Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-12 Miaomiao Niu; Liying Zhang; Yikang Wang; Runqi Tu; Xiaotian Liu; Jian Hou; Wenqian Huo; Zhenxing Mao; Zhenfei Wang; Chongjian Wang
Few studies have developed risk models for dyslipidaemia, especially for rural populations. Furthermore, the performance of genetic factors in predicting dyslipidaemia has not been explored. The purpose of this study is to develop and evaluate prediction models with and without genetic factors for dyslipidaemia in rural populations. A total of 3596 individuals from the Henan Rural Cohort Study were
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Discordant serum lipid parameters Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-11 Ozge Kurmus; Turgay Aslan; Murat Eren; Kursat Akbuga
Dear Editor, We read with interest the paper by Fonseca et al. entitled “Apolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterol” [1]. The authors state that 22% of the diabetic patients with target low-density lipoprotein cholesterol (LDL-C) level had non-high-density lipoprotein
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The association of parameters of body composition and laboratory markers with the severity of hypertriglyceridemia-induced pancreatitis Lipids Health Dis. (IF 2.906) Pub Date : 2021-02-11 Lifang Chen; Yingbao Huang; Huajun Yu; Kehua Pan; Zhao Zhang; Yi Man; Dingyuan Hu
Hypertriglyceridemia has arisen as the third leading cause of acute pancreatitis. This study aimed at exploring the association between the severity of hypertriglyceridemia-induced pancreatitis (HTGP) and computed tomography (CT)-based body composition parameters and laboratory markers. Laboratory and clinical parameters were collected from 242 patients with HTGP between 2017 and 2020. Severity of
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Correction to: Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study Lipids Health Dis. (IF 2.906) Pub Date : 2021-01-30 Xiaoli Li; Guilong Li; Tiantian Cheng; Jing Liu; Guangyao Song; Huijuan Ma
An amendment to this paper has been published and can be accessed via the original article.
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The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: a randomized controlled trial Lipids Health Dis. (IF 2.906) Pub Date : 2021-01-29 Maryam Yahay; Zahra Heidari; Zahra Allameh; Reza Amani
Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrinopathies and metabolic disorders in women during their reproductive years. It is often associated with dyslipidemia and other risk factors of cardiovascular diseases (CVD). This study was aimed to evaluate dietary intervention effects with canola and olive oils compared to sunflower oil on lipid profile and fatty liver severity among
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis Lipids Health Dis. (IF 2.906) Pub Date : 2021-01-18 Susanne Feder; Reiner Wiest; Thomas S. Weiss; Charalampos Aslanidis; Doris Schacherer; Sabrina Krautbauer; Gerhard Liebisch; Christa Buechler
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is of particular importance in cholesterol metabolism with high levels contributing to hypercholesterolemia. Cholesterol and sphingolipids are low in patients with liver cirrhosis. Purpose of this study was to find associations of plasma PCSK9 with circulating cholesterol and sphingolipid species and measures of liver disease severity in patients
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Empagliflozin protects against atherosclerosis progression by modulating lipid profiles and sympathetic activity Lipids Health Dis. (IF 2.906) Pub Date : 2021-01-12 Yihai Liu; Jiamin Xu; Mingyue Wu; Biao Xu; Lina Kang
Several large clinical trials have confirmed the cardioprotective role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes. However, whether empagliflozin, as an SGLT2i, could alleviate atherosclerosis progression in non-diabetic states remain unknown. ApoE-/- mice were fed a Western diet for 12 weeks to induce atherosclerosis. On the 7th week, a group of mice were
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Evaluation of cardiovascular risk factors in patients with familial hypercholesterolemia from the North-Eastern area of Romania Lipids Health Dis. (IF 2.906) Pub Date : 2021-01-11 Cristiana-Elena Vlad; Liliana Foia; Laura Florea; Irina-Iuliana Costache; Andreea Covic; Roxana Popescu; Delia Reurean-Pintilei; Adrian Covic
Familial hypercholesterolemia(FH) is one of the most frequent and important monogenic cholesterol pathologies. Traditional and non-traditional cardiovascular risk factors increase the prevalence of atherosclerotic cardiovascular disease(ASCVD) in this population. The aims of the study were: (a) to identify FH patients in the North-Eastern part of Romania and to analyze demographic, clinical and paraclinical
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Association between lipoprotein cholesterol and future cardiovascular disease and mortality in older adults: a Korean nationwide longitudinal study Lipids Health Dis. (IF 2.906) Pub Date : 2021-01-06 Seung Hee Kim; Ki Young Son
Dyslipidemia is considered an independent health risk factor of cardiovascular disease (CVD), a leading cause of mortality in older adults. Despite its importance, there have been few reports on the association between lipoprotein cholesterol and future CVD and cardiovascular (CV) mortality among elderly Asians aged ≥ 65 years. This study investigated the association between lipoprotein cholesterol
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LDL-cholesterol change and goal attainment following statin intensity titration among Asians in primary care: a retrospective cohort study Lipids Health Dis. (IF 2.906) Pub Date : 2021-01-06 Hao Sen Andrew Fang; Qiao Gao; Mong Li Lee; Wynne Hsu; Ngiap Chuan Tan
Clinical trials have demonstrated that either initiating or up-titrating a statin dose substantially reduce Low-Density Lipoprotein-Cholesterol (LDL-C) levels. However, statin adherence in actual practice tends to be suboptimal, leading to diminished effectiveness. This study aims to use real-world data to determine the effect on LDL-C levels and LDL-C goal attainment rates, when selected statins are
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Association between serum uric acid and triglycerides in Chinese children and adolescents with short stature Lipids Health Dis. (IF 2.906) Pub Date : 2021-01-06 Yuntian Chu; Qianqian Zhao; Mei Zhang; Bo Ban; Hongbing Tao
Elevated triglyceride (TG) levels are a biomarker for cardiovascular disease (CVD) risk. The correlation between serum uric acid (SUA) and TG concentrations in adults or obese children is well established. However, studies on SUA and TG in children with short stature are limited. To determine the relationship between SUA and TG levels in short children and adolescents. This was a cross-sectional evaluation
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A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet Lipids Health Dis. (IF 2.906) Pub Date : 2020-12-14 Noriko Suzuki-Kemuriyama; Akari Abe; Kiniko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
Nonalcoholic steatohepatitis (NASH) is a form of liver disease characterized by steatosis, necroinflammation, and fibrosis, resulting in cirrhosis and cancer. Efforts have focused on reducing the intake of trans fatty acids (TFAs) because of potential hazards to human health and the increased risk for NASH. However, the health benefits of reducing dietary TFAs have not been fully elucidated. Here,
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Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease Lipids Health Dis. (IF 2.906) Pub Date : 2020-12-09 Elisabeth M. Haberl; Rebekka Pohl; Lisa Rein-Fischboeck; Marcus Höring; Sabrina Krautbauer; Gerhard Liebisch; Christa Buechler
Emerging data support a role for lipids in non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in humans. With experimental models such data can be challenged or validated. Mice fed a low-methionine, choline-deficient (LMCD) diet develop NASH and, when injected with diethylnitrosamine (DEN), HCC. Here, lipidomic analysis was used to elucidate whether the NASH and HCC associated
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The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content Lipids Health Dis. (IF 2.906) Pub Date : 2020-12-07 Juliann Jugan; P. Monica Lind; Samira Salihovic; Jordan Stubleski; Anna Kärrman; Lars Lind; Michele A. La Merrill
Lipoproteins at aberrant levels are known to play a role in cardiovascular disease. The metabolite of the insecticide dichlorodiphenyltrichloroethane (DDT), p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE), physically associates with lipids and accumulates in adipose tissue. Little is known about which lipoproteins associate with p,p’-DDE. An association between p,p’-DDE exposure and altered levels
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Relationship between serum triglyceride to high-density lipoprotein cholesterol ratio and sarcopenia occurrence rate in community-dwelling Chinese adults Lipids Health Dis. (IF 2.906) Pub Date : 2020-12-04 Na Wang; Mengjun Chen; Danhong Fang
A study conducted on elderly Korean men showed that a high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was associated with a high risk of developing sarcopenia. We aimed to determine such an association in community-dwelling Chinese adults. From May 2016 to August 2017, we conducted a cross-sectional study on Chinese adults at the First Affiliated Hospital of Wenzhou
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The extended lipid panel assay: a clinically-deployed high-throughput nuclear magnetic resonance method for the simultaneous measurement of lipids and Apolipoprotein B Lipids Health Dis. (IF 2.906) Pub Date : 2020-12-01 Erwin Garcia; Dennis W. Bennett; Margery A. Connelly; Elias J. Jeyarajah; Franklin C. Warf; Irina Shalaurova; Steven P. Matyus; Justyna Wolak-Dinsmore; David N. Oskardmay; Randolph M. Young; Maureen Sampson; Alan T. Remaley; James D. Otvos
Standard lipid panel assays employing chemical/enzymatic methods measure total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C), from which are calculated estimates of low-density lipoprotein cholesterol (LDL-C). These lipid measures are used universally to guide management of atherosclerotic cardiovascular disease risk. Apolipoprotein B (apoB) is generally acknowledged
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Retraction Note: Glycol chitosan incorporated retinoic acid chlorochalcone (RACC) nanoparticles in the treatment of Osteosarcoma Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-30 Yan-Guo Qin; Lan-Yu Zhu; Chen-Yu Wang; Bo-Yan Zhang; Qing-Yu Wang; Rui-Yan Li; Zhen Liu
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12944-020-01416-2
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Association between the alanine aminotransferase/aspartate aminotransferase ratio and new-onset non-alcoholic fatty liver disease in a nonobese Chinese population: a population-based longitudinal study Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-25 Yang Zou; Ling Zhong; Chong Hu; Guotai Sheng
The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio has been considered an alternative marker for hepatic steatosis. However, few studies have investigated the association of the ALT/AST ratio with non-alcoholic fatty liver disease (NAFLD) in nonobese people. A total of 12,127 nonobese participants who were free of NAFLD participated in this study. The participants were divided
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Association of dietary pattern and physical activity with lipid-related indices among Chinese population: a cross-sectional study Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-23 Qiao Guo; Zuchang Ma; Changan Zhu; Qiang Zeng
To explore the relationship between dietary patterns, physical activity and lipid-related indices in Chinese Population. This study included 21,472 (72.3% men) participants aged 16 to 78 years. Data of anthropometric measurements, biochemical tests and questionnaires were collected through a physical examination. Diet patterns were identified through factor analysis and five patterns were retained
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Inverse association between triglyceride glucose index and muscle mass in Korean adults: 2008–2011 KNHANES Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-22 Sung-Ho Ahn; Jun-Hyuk Lee; Ji-Won Lee
Since sarcopenia is an important risk factor for falls or cardiovascular disease, early detection and prevention of sarcopenia are being increasingly emphasized. Emerging evidence has indicated relationships between sarcopenia, insulin resistance, and inflammation. The triglyceride glucose (TyG) index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been shown
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Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-22 Shouxing Yang; Jinwei Zhong; Mengsi Ye; Lei Miao; Guangrong Lu; Changlong Xu; Zhanxiong Xue; Xinhe Zhou
The non-HDL-cholesterol to HDL-cholesterol (NHDLC/HDLC) ratio is closely related to a variety of dyslipidemia-related diseases. This study examined the relationship between the NHDLC/HDLC ratio and non-alcoholic fatty liver (NAFLD) in children and adolescents. This cross-sectional survey included a total of 7759 eligible Chinese children and adolescents (5692 boys and 2067 girls) who received routine
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Emerging insights into the relationship between hyperlipidemia and the risk of diabetic retinopathy Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-19 Yuyu Chou; Jin Ma; Xin Su; Yong Zhong
Hyperlipidemia is correlated with a series of health problems. Notably, aside from its established role in promoting cardiovascular morbidity and mortality, hyperlipidemia has also been considered for modulating the risk and the severity of multiple metabolic disorders. According to the results of epidemiologic investigations, several certain circulating lipoprotein species are correlated with the
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Prognostic impact of the atherogenic index of plasma in type 2 diabetes mellitus patients with acute coronary syndrome undergoing percutaneous coronary intervention Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-16 Xiaoteng Ma; Yan Sun; Yujing Cheng; Hua Shen; Fei Gao; Jing Qi; Lixia Yang; Zhijian Wang; Dongmei Shi; Yuyang Liu; Xiaoli Liu; Yujie Zhou
The association of the atherogenic index of plasma (AIP), an emerging lipid index that can predict the risk for cardiovascular disease, with adverse outcomes in type 2 diabetes mellitus (T2DM) patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) has not been determined. Therefore, the aim of this study was to investigate whether the AIP could independently
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Pharmacokinetics and pharmacodynamics of HTD1801 (berberine ursodeoxycholate, BUDCA) in patients with hyperlipidemia Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-12 Adrian M. Di Bisceglie; Gerald F. Watts; Philip Lavin; Meng Yu; Ru Bai; Liping Liu
Reduction in elevated serum cholesterol concentrations is important in the management of individuals at risk of atherosclerotic cardiovascular disease (ASCVD), such as myocardial infarction and thrombotic stroke. Although HMGCoA reductase inhibitors (“statins”) are frequently used for this purpose, a significant proportion of patients remain at increased residual risk of ASCVD as they do not adequately
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A U-shaped association between the LDL-cholesterol to HDL-cholesterol ratio and all-cause mortality in elderly hypertensive patients: a prospective cohort study Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-12 Yu Yu; Minghui Li; Xiao Huang; Wei Zhou; Tao Wang; Lingjuan Zhu; Congcong Ding; Yu Tao; Huihui Bao; Xiaoshu Cheng
The low-density lipoprotein cholesterol/high-density lipoprotein- cholesterol (LDL-C/HDL-C) ratio is an excellent predictor of cardiovascular disease (CVD). However, previous studies linking the LDL-C/HDL-C ratio to mortality have yielded inconsistent results and been limited by short follow-up periods. Therefore, the aim of the present study was to determine whether the LDL-C/HDL-C ratio could be
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Utilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes - a nationwide cross-sectional study (TEMD dyslipidemia study) Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-11 Fahri Bayram; Alper Sonmez; Cem Haymana; Tevfik Sabuncu; Oguzhan Sitki Dizdar; Eren Gurkan; Ayse Kargili Carlioglu; Kemal Agbaht; Didem Ozdemir; Ibrahim Demirci; Cem Barcin; Serpil Salman; Tamer Tetiker; Mustafa Kemal Balci; Nur Kebapci; Canan Ersoy; Volkan Yumuk; Peter P. Toth; Ilhan Satman
Attaining acceptable levels of LDL Cholesterol (LDL-C) significantly improves cardiovascular (CV) outcomes in patients with type 2 diabetes mellitus (T2DM). The LDL-C target attainment and the characteristics of patients attaining these targets were investigated in this study. Furthermore, the reasons for not choosing statins and the physicians’ attitudes on the treatment of diabetic dyslipidemia were
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Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-08 Xiaoli Li; Guilong Li; Tiantian Cheng; Jing Liu; Guangyao Song; Huijuan Ma
Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults. This retrospective cohort study was conducted using data
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Evaluation of lipid ratios and triglyceride-glucose index as risk markers of insulin resistance in Iranian polycystic ovary syndrome women Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-08 Asma Kheirollahi; Maryam Teimouri; Mehrdad Karimi; Akram Vatannejad; Nariman Moradi; Nasrin Borumandnia; Asie Sadeghi
Insulin resistance has a vital role in the pathophysiology of polycystic ovary syndrome (PCOS). Previous investigations have shown that some lipid ratios could be a simple clinical indicator of insulin resistance (IR) in some disorders and ethnicities. The present study was conducted to evaluate the correlation between triglyceride to HDL-cholesterol (TG/HDL-C), total cholesterol to HDL-cholesterol
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Hyperlipidemia and mortality associated with diabetes mellitus co-existence in Chinese peritoneal dialysis patients Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-07 Xin Wei; Yueqiang Wen; Qian Zhou; Xiaoran Feng; Fen Fen Peng; Niansong Wang; Xiaoyang Wang; Xianfeng Wu
To evaluate associations between diabetes mellitus (DM) coexisting with hyperlipidemia and mortality in peritoneal dialysis (PD) patients. This was a retrospective cohort study with 2939 incident PD patients in China from January 2005 to December 2018. Associations between the DM coexisting with hyperlipidemia and mortality were evaluated using the Cox regression. Of 2939 patients, with a median age
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Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among the Chinese male population: two cohort studies Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-04 Yafei Liu; Zhaohui Du; Jiadong Ji; Jingru Li; Deming Bi; Fang Tang
Previous studies have shown that serum carcinoembryonic antigen (CEA) is independently associated with metabolic syndrome (MetS). However, these studies were mainly cross-sectional analyses, and cause was not clarified. In the present study, two bidirectional cohort studies were conducted to investigate the bidirectional associations between CEA and MetS using a Chinese male sample cohort. The initial
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Association between statin use and osteoporotic fracture in patients with chronic obstructive pulmonary disease: a population-based, matched case-control study Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-03 Hung-Yi Chen; Pei-Yu Su; Tsung-Kun Lin; Gwo-Ping Jong
In the recent years, chronic obstructive pulmonary disease (COPD) has been found to be associated with a higher risk of new-onset osteoporotic fracture (NOF). However, the existence of such an association in the COPD patients receiving statin treatment remains unknown. The present study aimed to investigate the association between COPD and NOF in statin-treated patients. The present study was conducted
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Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension Lipids Health Dis. (IF 2.906) Pub Date : 2020-11-03 Congcong Ding; Yang Chen; Yumeng Shi; Minghui Li; Lihua Hu; Wei Zhou; Tao Wang; Lingjuan Zhu; Xiao Huang; Huihui Bao; Xiaoshu Cheng
Data on the relationship between nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C)] and the risk of peripheral artery disease (PAD) are limited. The present study investigated the relationship of nontraditional
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Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-30 Afsane Gholamrezayi; Maryam Mohamadinarab; Pegah Rahbarinejad; Soudabeh Fallah; Shekufe Rezghi Barez; Leila Setayesh; Nariman Moradi; Reza Fadaei; Elham Chamani; Tahmine Tavakoli
Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn’s disease (CD) patients who were diagnosed by pathological examination. In
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Association between triglyceride glucose-body mass index and non-alcoholic fatty liver disease in the non-obese Chinese population with normal blood lipid levels: a secondary analysis based on a prospective cohort study Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-28 Yaling Li; Rui Zheng; Jie Li; Shuyi Feng; Li Wang; Zhiming Huang
Both triglyceride glucose-body mass index (TyG-BMI) and non-alcoholic fatty liver disease (NAFLD) are linked to insulin resistance (IR). Prospective studies linking TyG-BMI to NAFLD have been limited by short follow-up. This study investigated the longitudinal association between TyG-BMI and NAFLD occurrence in the non-obese Chinese individuals. This study determined TyG-BMI at baseline and the incidence
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An inverse association of weight and the occurrence of asymptomatic gallbladder stone disease in hypercholesterolemia patients: a case-control study Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-23 Binwu Sheng; Qingbin Zhao; Mao Ma; Jianqin Zhang
Despite the fact that the majority of gallstones formed in the gallbladder are mainly composed of cholesterol, as they are formed from cholesterol-supersaturated bile, and hypercholesterolemia is a common metabolic disorder, which is closely related to cardiac, hepatic, renal and other oxidative damage inflammation and necrosis, there is still no consensus regarding the contribution of blood serum
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Correction to: The intake assessment of diverse dietary patterns on childhood hypertension: alleviating the blood pressure and lipidemic factors with low-sodium seafood rich in omega-3 fatty acids Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-21 Anahita Izadi; Leila Khedmat; Reza Tavakolizadeh; Sayed Yousef Mojtahedi
An amendment to this paper has been published and can be accessed via the original article.
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Elevated triglyceride-glucose (TyG) index predicts incidence of Prediabetes: a prospective cohort study in China Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-15 Jing Wen; Anping Wang; Guangxu Liu; Meiping Wang; Yingting Zuo; Wei Li; Qi Zhai; Yiming Mu; Herbert Y. Gaisano; Yan He; Jingtao Dou
Prediabetes has become a pandemic. This study aimed to identify a better predictor for the incidence of prediabetes, which we hypothesize to be the triglyceride-glucose (TyG) index, a simplified insulin resistance index. We compared its predictive value with the other common risk factors of prediabetes. The participants of this analysis were derived from the Risk Evaluation of cAncers in Chinese diabeTic
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A dose-independent association of triglyceride levels with all-cause mortality among adults population Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-15 Yu-qing Huang; Xiao-cong Liu; Kenneth Lo; Ying-qing Feng; Bin Zhang
The relationship between triglyceride (TG) level and the mortality risk of all-cause and cardiovascular disease is not entirely consistent among adults. The present analysis included adult participants from National Health and Nutrition Examination Surveys (NHANES) between the periods 1999–2014. The levels of TG were categorized into < 150, 150–199, 200–250 and ≥ 250 mg/dL respectively. Multivariate
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Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9 Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-14 Ting Zhang; Rui Lu; Yibing Chen; Yuguo Yuan; Shaozheng Song; Kunning Yan; Yiwen Zha; Wenwen Zhuang; Yong Cheng; Jingyan Liang
Congenital hyper-homocysteinemia (HHcy) is caused by a defective cystathionine β-synthase (CBS) gene, and is frequently associated with dyslipdemia. The aim of this study was to further elucidate the effect of mutated CBS gene on circulating lipids using a rabbit model harboring a homozygous G307S point mutation in CBS. CRISPR/Cas9 system was used to edit the CBS gene in rabbit embryos. The founder
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Higher levels of the soluble receptor for advanced glycation end products and lower levels of the extracellular newly identified receptor for advanced glycation end products were associated with lipid-lowering drugs in patients with type 1 diabetes: a comparative cross-sectional study Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-14 Eva O. Melin; Jonatan Dereke; Magnus Hillman
The receptors for advanced glycation end products (RAGE) are increased in atherosclerotic plaques. Soluble (s)RAGE decreases, whereas the extracellular newly identified receptor for advanced glycation end products (EN-RAGE) increases inflammatory responses mediated by RAGE. The aims were to explore whether sRAGE, EN-RAGE and the EN-RAGE/sRAGE ratio, were associated with the use of lipid-lowering drugs
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Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-13 Jinyou Li; Qiang Li; Zhenyu Su; Qi Sun; Yong Zhao; Tienan Feng; Jiayuan Jiang; Feng Zhang; Haitao Ma
Lung cancer has high morbidity and mortality across the globe, and lung adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid metabolism is related to the development of cancer. Analysis of lipid-related transcriptome helps shed light on the diagnosis and prognostic biomarkers of LUAD. In this study, expression analysis of 1045 lipid metabolism-related genes was performed between
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The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-12 Yan Mao; Lin Yang; Qian Chen; Guoqing Li; Yao Sun; Jiamin Wu; Zichao Xiong; Yuanwei Liu; Haiyue Li; Jianfeng Liu; Yong Zhang
Stroke is a sudden disorder of cerebral blood circulation. Many studies have illustrated that dyslipidemia, hypertension, diabetes, smoking and excessive drinking are the traditional risk factors for stroke. This study aimed to observe the relationship between CYP1A1 and CYP1A2 variants and stroke risk in the Chinese population. Agena MassARRAY Assay was used to genotype four single nucleotide polymorphisms
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Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-10 Ling Pei; Huangmeng Xiao; Fenghua Lai; Zeting Li; Zhuyu Li; Shufan Yue; Haitian Chen; Yanbing Li; Xiaopei Cao
This study aimed to analyze the incidence of early postpartum dyslipidemia and its potential predictors in women with a history of gestational diabetes mellitus (GDM). This was a retrospective study. Five hundred eighty-nine women diagnosed with GDM were enrolled and followed up at 6–12 weeks after delivery. A 75 g oral glucose tolerance test (OGTT) and lipid levels were performed during mid-trimester
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Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-08 Gregory C. Henderson; Valeria Martinez Tenorio; Marc A. Tuazon
The content of triacylglycerol (TAG) in the liver is known to rapidly increase after a single bout of exercise followed by recovery to sedentary levels. The response of other hepatic lipids, and acyl chain composition of lipid classes, would provide a deeper understanding of the response of hepatic lipid metabolism to acute exercise. Female mice performed a single bout of continuous exercise (CE),
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The triglyceride-glucose index is associated with the severity of hepatic steatosis and the presence of liver fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-07 Wen Guo; Jing Lu; Pei Qin; Xiaona Li; Wenfang Zhu; Juan Wu; Nianzhen Xu; Qun Zhang
The triglyceride-glucose index (TyG) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD). Its association with the severity of hepatic steatosis and liver fibrosis in NAFLD is poorly understood. This study evaluated the relationship between these factors in NAFLD. A total of 4784 participants who underwent ultrasonography were enrolled. Anthropometric and biochemical measurements were
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LDL-C/HDL-C is associated with ischaemic stroke in patients with non-valvular atrial fibrillation: a case-control study Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-07 Xiao-Xue Zhang; Meng Wei; Lu-Xiang Shang; Yan-Mei Lu; Ling Zhang; Yao-Dong Li; Jiang-Hua Zhang; Qiang Xing; Zu Kela Tu-Erhong; Bao-Peng Tang; Xian-Hui Zhou
This study explored the relationships between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in patients with non-valvular atrial fibrillation (NVAF) in Xinjiang. The findings could provide a theoretical and therapeutic basis for NVAF patients. NVAF patients who were admitted to 10 medical centres across Xinjiang were divided
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Effect of intermittent versus continuous calorie restriction on body weight and cardiometabolic risk markers in subjects with overweight or obesity and mild-to-moderate hypertriglyceridemia: a randomized trial Lipids Health Dis. (IF 2.906) Pub Date : 2020-10-07 Mahsa Maroofi; Javad Nasrollahzadeh
Intermittent calorie restriction (ICR) is a novel method of dietary restriction for body weight control with the potential to improve obesity-related cardiometabolic markers, but the impact of this diet on subjects with hypertriglyceridemia (HTG) remains unknown. Eighty-eight subjects with overweight or obesity and mild-to-moderate HTG were randomized to the continuous calorie restriction (CCR) group
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