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Disturbances in mitochondrial bioenergetics and control quality and unbalanced redox homeostasis in the liver of a mouse model of mucopolysaccharidosis type II Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-18 Camila Vieira Pinheiro, Rafael Teixeira Ribeiro, Ana Cristina Roginski, Morgana Brondani, Ângela Beatris Zemniaçak, Chrístofer Ian Hernandez Hoffmann, Alexandre Umpierrez Amaral, Moacir Wajner, Guilherme Baldo, Guilhian Leipnitz
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Abnormal upregulation of NUBP2 contributes to cancer progression in colorectal cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-16 Danfeng Lan, Junyu Wang, Guishun Sun, Lixia Jiang, Qiyun Chen, Sha Li, Haiyan Qu, Yibo Wang, Bian Wu
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Untargeted metabolomics identifies indole-3-propionic acid to relieve Ang II-induced endothelial dysfunction in aortic dissection Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-14 Qi Wang, Hui Lv, Mierxiati Ainiwan, Gulinazi Yesitayi, Asiya Abudesimu, Dilixiati Siti, Aliya Aizitiaili, Xiang Ma
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miR-575/RIPK4 axis modulates cell cycle progression and proliferation by inactivating the Wnt/β-catenin signaling pathway through inhibiting RUNX1 in colon cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-14
Abstract Receptor interacting protein serine/threonine kinase 4 (RIPK4) is widely involved in human cancer development. Nevertheless, its role in colon cancer (COAD) has not been elucidated till now. Our research aimed at exploring the function and underlying molecular mechanism of RIPK4 in COAD progression. Through bioinformatic analyses and RT-qPCR, RIPK4 was discovered to be increased in COAD cells
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Walnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet type Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-13
Abstract Dietary interventions that modulate the brown adipose tissue (BAT) thermogenic activity could represent a promising therapy for metabolic disorders. In order to examine if dietary walnuts intake regulates the expression of BAT thermogenic markers levels in healthy and metabolically challenged (fructose fed) animals, rats were initially divided into the control and fructose-fed groups. After
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ATG4B as a novel biomarker for abdominal aortic aneurysm: integrated evaluation through experimental and bioinformatics analyses Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-13 Jingjing Jing, Qiuyan Sun, Rongqi Zhang, Chao Yang, Jun Yang, Chunyan Ma, Tan Li
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LncRNA MCM3AP-AS1 promotes chemoresistance in triple-negative breast cancer through the miR-524-5p/RBM39 axis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-12 Yueping Wang, Xuedong Wang, Haiyi Sun, Ziyun Zhang, Juan Gu
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Lycorine hydrochloride interferes with energy metabolism to inhibit chemoresistant glioblastoma multiforme cell growth through suppressing PDK3 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-11 Qingsheng Dong, Wanxiang Niu, Maolin Mu, Chengkun Ye, Pengfei Wu, Shanshan Hu, Chaoshi Niu
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Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-11 Kai Huang, Chen Yan, Lina Abdelghany, Xu Zhang, Keiichi Jingu, Tao-Sheng Li
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A specific inflammatory suppression fibroblast subpopulation characterized by MHCII expression in human dilated cardiomyopathy Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-10
Abstract Dilated cardiomyopathy (DCM) is a significant cause of heart failure that requires heart transplantation. Fibroblasts play a central role in the fibro-inflammatory microenvironment of DCM. However, their cellular heterogeneity and interaction with immune cells have not been well identified. An integrative analysis was conducted on single-cell RNA sequencing (ScRNA-Seq) data from human left
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Exosomes derived from human umbilical cord mesenchymal stem cells decrease neuroinflammation and facilitate the restoration of nerve function in rats suffering from intracerebral hemorrhage Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-08 Chengrui Nan, Yan Zhang, Aobo Zhang, Yunpeng Shi, Dongdong Yan, Zhimin Sun, Qianxu Jin, Haoran Huo, Yayu Zhuo, Zongmao Zhao
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IL-33 aggravates extranodal NK/T cell lymphoma aggressiveness and angiogenesis by activating the Wnt/β-catenin signaling pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-05
Abstract Extranodal NK/T cell lymphoma (ENKTCL) is an extremely aggressive form of lymphoma and lacks of specific diagnostic markers. The study intended to unearth the role of interleukin-33 (IL-33) in ENKTCL. RT-qPCR was conducted to assess mRNA levels of ENKTCL tissues and cells, while western blot assay was performed for evaluating protein levels. Plate cloning experiment and transwell assay were
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Protective effect of SERCA2a-SUMOylation by SUMO-1 on diabetes-induced atherosclerosis and aortic vascular injury Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-05 Jinlin Liu, Shifang Xu, Bin Gao, Meng Yuan, Li Zhong, Rui Guo
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Long-term intake of sulforaphene alleviates d-galactose-induced skin senescence by activating AMPK-Sirt 1 pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-05 Bo Zhang, Pengtao Liu, Huakang Sheng, Yongzhi Han, Qipeng Yuan
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New insights of DsbA-L in the pathogenesis of metabolic diseases Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-02
Abstract Metabolic diseases, such as obesity, diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD), are abnormal conditions that result from disturbances of metabolism. With the improvement of living conditions, the morbidity and mortality rates of metabolic diseases are steadily rising, posing a significant threat to human health worldwide. Therefore, identifying novel effective targets
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P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-02 Marcos Munoz, Christopher Solis, Maximilian McCann, Jooman Park, Koreena Rafael-Clyke, Shamim A. K. Chowdhury, Yuwei Jiang, Paola C. Rosas
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Erythronecroptosis: an overview of necroptosis or programmed necrosis in red blood cells Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-01
Abstract Necroptosis is considered a programmed necrosis that requires receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3), and pore-forming mixed lineage kinase domain-like protein (MLKL) to trigger a regulated cell membrane lysis. Membrane rupture in necroptosis has been shown to fuel innate immune response due to release of damage-associated molecular patterns
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YAP/TEAD involvement in resistance to paclitaxel chemotherapy in lung cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-01 S. Brosseau, P. Abreu, C. Bouchez, L. Charon, Y. Kieffer, G. Gentric, V. Picant, I. Veith, J. Camonis, S. Descroix, F. Mechta-Grigoriou, M. C. Parrini, G. Zalcman
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The pharmaco-epigenetics of hypertension: a focus on microRNA Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-29 Serge Yaacoub, Ammar Boudaka, Ali AlKhatib, Gianfranco Pintus, Amirhossein Sahebkar, Firas Kobeissy, Ali H. Eid
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Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-28
Abstract Cancer remains a major global health concern with high mortality rates mainly due to late diagnosis and poor prognosis. Long non-coding RNAs (lncRNAs) are emerging as key regulators of gene expression in human cancer, functioning through various mechanisms including as competing endogenous RNAs (ceRNAs) and indirectly regulating miRNA expression. LncRNAs have been found to have both oncogenic
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KIF4A promotes epithelial–mesenchymal transition by activating the TGF-β/SMAD signaling pathway in glioma cells Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-27 Yao Xu, Guangren Xue, Lei Zhou, Gaotian Wu, Lingji Hu, Shuchen Ma, Jian Zhang, Xiangdong Li
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CircHAT1 regulates the proliferation and phenotype switch of vascular smooth muscle cells in lower extremity arteriosclerosis obliterans through targeting SFRS1 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-26 Xian-ying Huang, Fang-yong Fu, Kai Qian, Qiao-li Feng, Sai Cao, Wei-yu Wu, Yuan-lin Luo, Wei-jie Chen, Zhi Zhang, Shui-chuan Huang
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Neutrophil extracellular traps: a catalyst for atherosclerosis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-24 Yinyu Wang, Cuiping Wang, Jiayan Li
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MYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-23 Cuifen Zhang, Ke Wang, Jiahao Tao, Chuangjie Zheng, Linzhu Zhai
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Aerobic exercise mitigates high-fat diet-induced cardiac dysfunction, pyroptosis, and inflammation by inhibiting STING-NLRP3 signaling pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-22 Zujie Xu, Zheying Ma, Xiaoqin Zhao, Bing Zhang
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Role of AMP deaminase in diabetic cardiomyopathy Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-22
Abstract Diabetes mellitus is one of the major causes of ischemic and nonischemic heart failure. While hypertension and coronary artery disease are frequent comorbidities in patients with diabetes, cardiac contractile dysfunction and remodeling occur in diabetic patients even without comorbidities, which is referred to as diabetic cardiomyopathy. Investigations in recent decades have demonstrated that
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METTL3-mediated m6A modification of NORAD inhibits the ferroptosis of vascular smooth muscle cells to attenuate the aortic dissection progression in an YTHDF2-dependent manner Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-22 Mingfang Liao, Sili Zou, Jianjin Wu, Jun Bai, Yandong Liu, Kangkang Zhi, Lefeng Qu
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Identification of key genes of diabetic cardiomyopathy in hiPSCs-CMs based on bioinformatics analysis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-21 Shuo An, Hongchen Bi, Xiaoli Luo, Caiying Zhu, Min Wang, Aiming Pang, Yujie Cui
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Coronary microthrombi in the failing human heart: the role of von Willebrand factor and PECAM-1 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-21 Sawa Kostin, Theodoros Giannakopoulos, Manfred Richter, Florian Krizanic, Benjamin Sasko, Oliver Ritter, Nikolaos Pagonas
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Circ_0004872 deficiency attenuates ox-LDL-induced vascular smooth muscle cell dysfunction by miR-424-5p-dependent regulation of FRS2 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-20 Peng Qian, Xuanchao Cao, Qian Zhang, Meihua Gao, Xin Liu, Lijie Yan
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Molecular mechanisms of ferroptosis in cardiovascular disease Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-19 Qun Zeng, Tingting Jiang
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Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-17 Yu Cong, Xin Cui, Yaqian Shi, Xinxing Pan, Ke Huang, Zhe Geng, Pengfei Xu, Lili Ge, Jin Zhu, Juan Xu, Xuemei Jia
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Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-14 Shan Gao, Qiaochu Cheng, Yaguang Hu, Xiaojuan Fan, Chen Liang, Chen Niu, Qianyan Kang, Ting Wei
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Exosomes released by oxidative stress-induced mesenchymal stem cells promote murine mammary tumor progression through activating the STAT3 signaling pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-13 Mansour Almouh, Katayoon Pakravan, Mohammad H. Ghazimoradi, Romina Motamed, Babak Bakhshinejad, Zuhair Mohammad Hassan, Sadegh Babashah
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P4HA3 promotes colon cancer cell escape from macrophage phagocytosis by increasing phagocytosis immune checkpoint CD47 expression Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-12 Hailang Zhou, Junwei Zou, Jingli Han, Aijun Zhou, Shu Huang
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WDR12/RAC1 axis promoted proliferation and anti-apoptosis in colorectal cancer cells Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-11
Abstract Background: WD repeat domain 12 (WDR12) plays a crucial role in the ribosome biogenesis pathway. However, its biological function in colorectal cancer (CRC) remains poorly understood. Therefore, this study aims to investigate the roles of WDR12 in the occurrence and progression of CRC, as well as its underlying mechanisms. Methods: The expression of WDR12 was assessed through The Cancer Genome
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Functional activity and morphology of isolated rat cardiac mitochondria under calcium overload. Effect of naringin Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-08 T. A. Kavalenia, E. A. Lapshina, T. V. Ilyich, Hu-Cheng Zhao, I. B. Zavodnik
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The frequency of the ACE I/D polymorphism in South America: a systematic review and meta-analysis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-03 Rebeca Gonçalves Trevisano, Helen Matias, Thais de Jesus Teani, Valmir Oliveira Silvino, Cirley Pinheiro Ferreira, Marcos Antonio Pereira dos Santos, Pedro Luiz Garcia Braga, Sandro Soares Almeida
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ER stress improvement by aerobic training or enalapril differently ameliorates pathological cardiac remodeling in obese mice Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-03 Amanda Conceição Pimenta Salles, Beatriz Alexandre-Santos, Thais de Souza Carvalho, Ana Beatriz Proença, Vinicius Sepúlveda-Fragoso, Tiago Fernandes, Edilamar Menezes Oliveira, Antonio Claudio Lucas da Nóbrega, Eliete Dalla Corte Frantz, D’Angelo Carlo Magliano
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TRPM2 knockdown attenuates myocardial apoptosis and promotes autophagy in HFD/STZ-induced diabetic mice via regulating the MEK/ERK and mTORC1 signaling pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-03
Abstract Diabetic cardiomyopathy (DCM) is a major complication of diabetes. Transient receptor potential melastatin 2 (TRPM2) activity increases in diabetic oxidative stress state, and it is involved in myocardial damage and repair. We explore the protective effect of TRPM2 knockdown on the progression of DCM. A type 2 diabetes animal model was established in C57BL/6N mice by long-term high-fat diet
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Non-coding RNAs and angiogenesis in cardiovascular diseases: a comprehensive review Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-02
Abstract Non-coding RNAs (ncRNAs) have key roles in the etiology of many illnesses, including heart failure, myocardial infarction, stroke, and in physiological processes like angiogenesis. In transcriptional regulatory circuits that control heart growth, signaling, and stress response, as well as remodeling in cardiac disease, ncRNAs have become important players. Studies on ncRNAs and cardiovascular
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ALKBH5 facilitates the progression of infantile hemangioma by increasing FOXF1 expression in a m6A-YTHDF2 dependent manner to activate HK-2 signaling Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-02 Kun Peng, Ren-Peng Xia, Fan Zhao, Yong Xiao, Ti-Dong Ma, Ming Li, Yong Feng, Chong-Gao Zhou
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Inhibitors of gastric acid secretion increase oxidative stress and matrix metalloproteinase-2 activity leading to vascular remodeling Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-01 Renato C. Nogueira, Jéssica M. Sanches-lopes, Gustavo H. Oliveira-Paula, Jose E. Tanus-Santos
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Vitamin D accelerates the subdural hematoma clearance through improving the meningeal lymphatic vessel function Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-31 Yupeng Chen, Xuanhui Liu, Jiangyuan Yuan, Shiying Dong, Meng Nie, Weiwei Jiang, Di Wu, Mingqi Liu, Tao Liu, Chenrui Wu, Chuang Gao, Jianning Zhang, Rongcai Jiang
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Apigenin accelerates wound healing in diabetic mice by promoting macrophage M2-type polarization via increasing miR-21 expression Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-23 Ke Li, Lijun Wu, Jingting Jiang
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The role of WWP1 and WWP2 in bone/cartilage development and diseases Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-22 Ying Wang, Zuping Wu, Cunyi Wang, Na Wu, Chenyu Wang, Shiyu Hu, Jiejun Shi
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Bone morphogenetic protein-2 and pulsed electrical stimulation synergistically promoted osteogenic differentiation on MC-3T3-E1 cells Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-16 Shaodong Xie, Deming Zeng, Hanwen Luo, Ping Zhong, Yu Wang, Zhiqiang Xu, Peibiao Zhang
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Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-16 Dana Macejova, Jakub Kollar, Pavel Bobal, Jan Otevrel, Daniela Schuster, Julius Brtko
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Long-chain polyunsaturated fatty acids influence colorectal cancer progression via the interactions between the intestinal microflora and the macrophages Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-13
Abstract The metabolism of long-chain polyunsaturated fatty acids (LCPUFAs) is closely associated with the risk and progression of colorectal cancer (CRC). This paper aims to investigate the role of LCPUFA in the crosstalk between intestinal microflora and macrophages, as well as the effects of these three parties on the progression of CRC. The metabolism and function of LCPUFA play important roles
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The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-08 Bingrui Zhang, Hua Wu, Jingwen Zhang, Cong Cong, Lin Zhang
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N6-methyladenosine-induced miR-182-5p promotes multiple myeloma tumorigenesis by regulating CAMK2N1 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-05 Jing Bao, Tingting Xu, Wanjie Wang, Han Xu, Xiaowen Chen, Ruixiang Xia
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Hypoxia-induced SHMT2 protein lactylation facilitates glycolysis and stemness of esophageal cancer cells Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-01-04 Zhe Qiao, Yu Li, Shaomin Li, Shiyuan Liu, Yao Cheng
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Drugs targeting TGF-β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion Mol. Cell. Biochem. (IF 4.3) Pub Date : 2023-12-29 Da Huo, Xin-yu Bi, Jun-ling Zeng, Da-mao Dai, Xiang-lin Dong
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HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress Mol. Cell. Biochem. (IF 4.3) Pub Date : 2023-12-25
Abstract Phenotypic change of vascular smooth muscle cells (VSMCs) is the main contributor of vascular pathological remodeling in atherosclerosis. The endoplasmic reticulum (ER) is critical for maintaining VSMC function through elimination of misfolded proteins that impair VSMC cellular function. ER-associated degradation (ERAD) is an ER-mediated process that controls protein quality by clearing misfolded
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Relevance and mechanism of STAT3/miR-221-3p/Fascin-1 axis in EGFR TKI resistance of triple-negative breast cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2023-12-25 Lu-Lu Jin, Hua-Jun Lu, Jun-Kang Shao, Yan Wang, Shi-Ping Lu, Bi-Fei Huang, Gui-Nv Hu, Hong-Chuan Jin, Chao-Qun Wang
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PTBP1 as a potential regulator of disease Mol. Cell. Biochem. (IF 4.3) Pub Date : 2023-12-22 Qi Yu, Tongtong Wu, Wenhong Xu, Junyuan Wei, Anqi Zhao, Miaomiao Wang, Meiying Li, Guangfan Chi
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The predictive value of the neutrophil/platelet ratio on in-hospital adverse events and long-term prognosis in patients with coronary artery disease after percutaneous coronary intervention and its possible internal mechanism Mol. Cell. Biochem. (IF 4.3) Pub Date : 2023-12-22 Yifei Xiang, Jilang Zeng, Xueqin Lin, Xiaoling Cai, Liwei Zhang, Manqing Luo, Gengyu Zhou, Xiaofang Chen, Biting Lin, Junhan Chen, fan Chen, Xuan Huang, Yansong Guo, Kai-Yang Lin
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Computational insights into NIMA-related kinase 6: unraveling mutational effects on structure and function Mol. Cell. Biochem. (IF 4.3) Pub Date : 2023-12-20 Nagesh Kishan Panchal, Shruti Mohanty, Sabina Evan Prince
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Ferroptosis: opening up potential targets for gastric cancer treatment Mol. Cell. Biochem. (IF 4.3) Pub Date : 2023-12-11 Yuwei Li, Jiangrong Liu, Shihua Wu, Juan Xiao, Zhiwei Zhang
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Dihydroartemisinin suppresses glioma growth by repressing ERRα-mediated mitochondrial biogenesis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2023-12-11 Wenxin Zhang, Yan Wang, Lu Chen, Haifei Chen, Huijie Qi, Yong Zheng, Yongli Du, Liudi Zhang, Tianxiao Wang, Qunyi Li