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Vitamin D fortification of foods – sensory, acceptability, cost, and public acceptance considerations J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-25 Kevin D. Cashman
In terms of vitamin D food fortification, there are a number of important considerations in relation to selection of the food vehicle and fortificant. While there has been much research focus on the ability of fortified foods to improve vitamin D status, other considerations, such as sensory properties and acceptability, cost, and public attitudes around vitamin D-fortified foods, have received less
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Neurosteroids: A potential target for neuropsychiatric disorders J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-17 Mengyu Wang, Suwan Hu, Xinghuo Fu, Huixuan Zhou, Siqi Yang, Chun Yang
Neurosteroids are steroids produced by endocrine glands and subsequently entering the brain, and also include steroids synthesis in the brain. It has been widely known that neurosteroids influence many neurological functions, including neuronal signaling, synaptic adaptations, and neuroprotective effects. In addition, abnormality in the synthesis and function of neurosteroids has been closely linked
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The effect of androgens on the risk of endometriosis sub-phenotypes and ovarian neoplasms: A Mendelian randomization study J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-17 Marija Gjorgoska, Tea Lanisnik Rizner
Endometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic strategies. The etiology and pathogenesis of both diseases remain ambiguous. Androgens in endometriosis could have a distinct role beyond serving as estrogen sources
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Beauvericin, produced by Fusarium oxysporum inhibits bisphenol A-induced proliferation of human breast cancer cell line by regulating ERα/p38 pathway J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-16 Da-Hyun Jeong, Da-Woon Jung, Ji-Won Kim, Hee-Seok Lee
Beauvericin (BEA) is a cyclic depsipeptide secondary metabolite of species. It causes chemical hazards in food products and exists in an environment containing soil and various food types. On the other hand, the purified BEA has various biological activities and is regarded as a potential candidate for pharmaceutical research. This study was performed to assess the anti-proliferation activity of BEA
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Letter to the Editor regarding “Serum steroid metabolite profiling by LC-MS/MS in two phenotypic male patients with HSD17B3 deficiency: Implications for hormonal diagnosis” J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-16 Takeshi Sato, Satsuki Nakano, Misa Honda, Satoshi Narumi, Tomohiro Ishii, Tomonobu Hasegawa
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MicroRNA-125b regulates vitamin D resistance by targeting CYP24A1 in the progression of gestational diabetes mellitus J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-11 KL Milan, Ravichandran Jayasuriya, Harithpriya Kannan, M Anuradha, Kunka Mohanram Ramkumar
Vitamin D deficiency is prevalent in pregnancy and has been associated with increased occurrences of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. CYP24A1, recognized as a key factor in vitamin D metabolism homeostasis, encodes 24-hydroxylase responsible for converting 25(OH)D3 and 1,25(OH)2D3 into inactive metabolites. Recently, we have reported CYP24A1 overexpression
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Synthesis of steroidal inhibitors for Mycobacterium tuberculosis J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-10 Luke R. Churchman, James R. Beckett, Lendl Tan, Kyra Woods, Daniel Z. Doherty, Amna Ghith, Paul V. Bernhardt, Stephen G. Bell, Nicholas P. West, James J. De Voss
Oxidised derivatives of cholesterol have been shown to inhibit the growth of (). The bacteriostatic activity of these compounds has been attributed to their inhibition of CYP125A1 and CYP142A1, two metabolically critical cytochromes P450 that initiate degradation of the sterol side chain. Here, we synthesise and characterise an extensive library of 28 cholesterol derivatives to develop a structure-activity
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Dedication – Carole Mendelson J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-10 Sam Mesiano
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Introduction to special edition J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-10 Sam Mesiano
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1,25(OH)2D3 improves diabetic wound healing by modulating inflammation and promoting angiogenesis J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-08 Yiming Ma, Yiting Gong, Ying Wu, Qiaofan Zhao, Ruyu Fu, Xiaoming Zhang, Ye Li, Xueyuan Zhi
Vitamin D was found to regulate inflammatory response and angiogenesis, which were often impaired in diabetic wound healing. This study aimed to investigate the effects of 1,25-dihydroxyvitamin D [1,25(OH)D] on diabetic wound healing both in vivo and in vitro. Diabetes was induced by high-fat diet combined with streptozotocin. After four weeks of establishing diabetic mouse model, full-thickness excisional
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Discovery of a novel androgen receptor antagonist, MEL-6, with stereoselective activity and optimization of its metabolic stability J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-03 Christine Helsen, Konstantina Karypidou, Joice Thomas, Wout De Leger, Tien Nguyen, Steven Joniau, Arnout Voet, Wim Dehaen, Frank Claessens
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GPER binding site detection and description: A flavonoid-based docking and molecular dynamics simulations study. J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-02-02 David Méndez-Luna, Sonia Guzmán-Velázquez, Itzia-Irene Padilla-Martínez, José-Rubén García-Sánchez, Martiniano Bello, Juan-Benjamín García-Vázquez, Humberto-Lubriel Mendoza-Figueroa, José Correa-Basurto
Flavonoids, a phenolic compounds class widely distributed in the plant kingdom, have attracted much interest for their implications on several health and disease processes. Usually, the consumption of this type of compounds is approximately 1 g/d, primarily obtained from cereals, chocolate, and dry legumes ensuring its beneficial role in maintaining the homeostasis of the human body. In this context
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Possible role of apelin on the ovarian steroidogenesis and uterine apoptosis of infantile mice: An in vitro study J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-01-19 Borgohain Anima, Guruswami Gurusubramanian, Vikas Kumar Roy
The expression of adipokines is well-known in the ovary and uterus. Recently we have shown that apelin and its receptor, APJ are developmentally regulated in the ovary and uterus of mice with elevation at postnatal day 14 (PND14). However, its role in the ovary and uterus of PND14 has not been investigated. Thus, we aimed to unravel the role of the apelin system (by APJ antagonist, ML221) on ovarian
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5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-01-19 Marie Munawar Cheema, Zuzana Macakova Kotrbova, Barbora Hrcka Krausova, Santosh Kumar Adla, Barbora Slavikova, Hana Chodounska, Miroslav Kratochvil, Jiri Vondrasek, David Sedlak, Martin Balastik, Eva Kudova
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Histopathological analysis of tumor microenvironment in adrenocortical carcinoma: Possible effects of in situ disorganized glucocorticoid production on tumor immunity J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-01-15 Yuki Ishikawa, Yuto Yamazaki, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kazuaki Tokodai, Fumiyoshi Fujishima, Shin Kawanabe, Takuyuki Katabami, Akira Ikeya, Miho Yamashita, Yutaka Oki, Hiroshi Nanjo, Fumitoshi Satoh, Akihiro Ito, Michiaki Unno, Takashi Kamei, Hironobu Sasano, Takashi Suzuki
Adrenocortical carcinoma (ACC) patients with glucocorticoid excess have been reported to be associated with decreased tumor-infiltrating immune cells, but the effects of in situ glucocorticoid production on tumor immunity have remained unknown. In addition, ACC was also known to harbor marked intra-tumoral heterogeneity of steroidogenesis or disorganized steroidogenesis. Therefore, in this study, we
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Effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2024-01-12 Guido S. Alvarez Quintero, Analia Lima, Paulina Roig, Maria Meyer, E. Ron de Kloet, Alejandro F. De Nicola, Laura I. Garay
There is growing evidence indicating that mineralocorticoid receptor (MR) expression influences a wide variety of functions in metabolic and immune response. The present study explored if antagonism of the MR reduces neuroinflammation in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE). Eplerenone (EPLE) (100 mg/kg dissolved in 30% 2-hydroxypropyl-β-cyclodextrin) was administered
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In silico characterization of the novel SDR42E1 as a potential vitamin D modulator J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-29 Nagham Nafiz Hendi, Georges Nemer
The short-chain dehydrogenase/reductase (SDR) superfamily encompasses enzymes that play essential roles in the metabolism of steroid hormones and lipids. Despite an enigmatic function, recent genetic studies have linked the novel SDR 42 extended-1 (SDR42E1) gene to 25-hydroxyvitamin D levels. This study investigated the potential SDR42E1 functions and interactions with vitamin D using bioinformatics
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Engineering of redox partners and cofactor NADPH supply of CYP68JX for efficient steroid two-step ordered selective hydroxylation activity J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-29 Wei Liu, Hui Li, Dongxin Guo, Yu Ni, Xiaomei Zhang, Jinsong Shi, Mattheos A.G. Koffas, Zhenghong Xu
CYP68JX, a P450 hydroxylase, derived from Colletotrichum lini ST-1 is capable of biotransforming dehydroepiandrosterone (DHEA) to 3β,7α,15α-trihydroxy-5-androstene-17-one (7α,15α-diOH-DHEA). Redox partners and cofactor supply are important factors affecting the catalytic activity of CYP68JX. In this study, the heterologous expression of CYP68JX in Saccharomyces cerevisiae BY4741 was realized resulting
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Sexual dimorphism in the gut microbiota and sexual dimorphism in chronic diseases: association or causation? J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-26 Dong-Song Liu, Xue-Song Wang, Xiao-Hui Zhong, Hong Cao, Feng Zhang
Understanding the sexual dimorphism in diseases is essential to investigate the pathogenesis of some chronic diseases (e.g., autoimmune diseases, etc). The gut microbiota has been found to show a notable impact on the pathology of several chronic diseases in recent years. Intriguingly, the composition of the gut microbiota varies between sexes. Here, we reviewed ‘facts and fiction’ regarding sexual
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Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-23 Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu
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CIRBP Increases the Synthesis and Secretion of Steroid Hormones by Activating Autophagy in Yak Granule Cells J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-22 Rui Zhang, Yangyang Pan, Meng Wang, Jinglei Wang, TongXiang Zhang, Ling Zhao, Ruihua Xu, Yaying Wang, Xiaohong Han, Xiaolin Ye, Yan Cui, Sijiu Yu
As a regulatory protein that upregulates transcription in response to various stresses, cold-induced RNA-binding protein (CIRBP) is involved in a variety of physiological pathological processes in cells. However, little is known about the role of CIRBP in regulating autophagy and the synthesis and secretion of ovarian steroid hormones (estradiol E2 and progesterone P4). This study aimed to explore
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Strategic food vehicles for vitamin D fortification and effects on vitamin D status: A systematic review and meta-analysis of randomised controlled trials J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-21 Kevin D. Cashman, Colette M. O’Neill
There has been growing interest in the potential of vitamin D food fortification in Europe as a means of addressing low vitamin D status. The WHO-FAO suggest that choosing a suitable food vehicle and ensuring the combination of the food vehicle and the fortificant will be efficacious and effective are of key importance to a successful food fortification programme. Our key objective was to conduct a
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Identification of maturation-inducing steroid in sturgeons via comprehensive analyses of steroids produced during oocyte maturation J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-19 Yuya Hasegawa, Ryohei Surugaya, Kazuki Tousaka, Shinji Adachi, Shigeho Ijiri
Although 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) and 17α, 20β, 21-trihydroxy-4-pregnen-3-one (20β-S) have been identified as maturation-inducing steroids (MIS) in several teleosts, to date, no MISs have been identified in sturgeons. As it remains possible that an unidentified steroid is an MIS in sturgeons, this study aimed to identify a sturgeon MIS via comprehensive analyses and maturation-inducing
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Prostate cancer androgen biosynthesis relies solely on CYP17A1 downstream metabolites J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-15 Gido Snaterse, Angela E. Taylor, J. Matthijs Moll, Donna M. O’Neil, Wilma J. Teubel, Wytske M. van Weerden, Wiebke Arlt, Johannes Hofland
Prostate cancer (PC) is dependent on androgen receptor (AR) activation by testosterone and 5α-dihydrotestosterone (DHT). Intratumoral androgen accumulation and activation despite systemic androgen deprivation therapy underlies the development of castration-resistant PC (CRPC), but the precise pathways involved remain controversial. Here we investigated the differential contributions of de novo androgen
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Urine steroid metabolomics as a diagnostic tool in primary aldosteronism J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-15 Alessandro Prete, Katharina Lang, David Pavlov, Yara Rhayem, Alice J. Sitch, Anna S. Franke, Lorna C. Gilligan, Cedric H.L. Shackleton, Stefanie Hahner, Marcus Quinkler, Tanja Dekkers, Jaap Deinum, Martin Reincke, Felix Beuschlein, Michael Biehl, Wiebke Arlt
Primary aldosteronism (PA) causes 5–10% of hypertension cases, but only a minority of patients are currently diagnosed and treated because of a complex, stepwise, and partly invasive workup. We tested the performance of urine steroid metabolomics, the computational analysis of 24-hour urine steroid metabolome data by machine learning, for the identification and subtyping of PA. Mass spectrometry-based
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Biotransformation of anabolic androgenic steroids in human skin cells J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-12 Lingyu Liu, Ziaul Karim, Nils Schlörer, Xavier de la Torre, Francesco Botrè, Christian Zoschke, Maria Kristina Parr
In comparison to well-known drug-metabolizing organs such as the liver, the metabolic capacity of human skin is still not well elucidated despite the widespread use of topical drug application. To gain a comprehensive insight into anabolic steroid metabolism in the skin, six structurally related anabolic androgenic steroids, testosterone, metandienone, methyltestosterone, clostebol, dehydrochloromethyltestosterone
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Activation of estrogen receptor induces differential proteomic responses mainly involving migration, invasion, and tumor development pathways in human testicular embryonal carcinoma NT2/D1 cells J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-12 Carla Macheroni, Giuseppe Gianini Figueirêdo Leite, Deborah Simão Souza, Carolina Meloni Vicente, José Thalles Lacerda, Maria Nathália Moraes, Maria Aparecida Juliano, Catarina Segreti Porto
The aims of the present study were to investigate the global changes on proteome of human testicular embryonal carcinoma NT2/D1 cells treated with 17β-estradiol (E2), and the effects of this hormone on migration, invasion, and colony formation of these cells. A quantitative proteomic analysis identified the presence of 1230 proteins in both E2-treated and control cells. The analysis revealed 75 differentially
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Progesterone receptor-Grb2 interaction is associated with better outcomes in breast cancer J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-08 Nattamolphan Wittayavimol, Erina Iwabuchi, Prangwan Pateetin, Yasuhiro Miki, Yoshiaki Onodera, Hironobu Sasano, Viroj Boonyaratanakornkit
In addition to mediating nuclear transcription, PR mediates extranuclear functions mainly through the PR polyproline domain (PPD) interaction with the SH3 domain of cytoplasmic signaling molecules. PR-PPD-SH3 interaction inhibits EGF-mediated signaling and decreases lung cancer cell proliferation. Grb2 is an essential adaptor molecule with an SH2 domain flanked by two SH3 domains. In this study, we
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Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-02 Renate Louw-du Toit, Mishkah Simons, Donita Africander
Progestins used in hormonal contraceptives and menopausal hormone therapy (MHT) have been linked to increased breast cancer risk. Whether the association holds for all progestins is unclear and the underlying mechanisms remain poorly understood. We directly compared the effects of four progestins (medroxyprogesterone acetate (MPA), norethisterone acetate (NET-A), levonorgestrel (LNG) and drospirenone
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The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-12-02 Elisa Giacomini, Luca Pagliardini, Sabrina Minetto, Monica Pinna, Fabiola Kleeman, Francesca Bonesi, Sofia Makieva, Valentina Pavone, Marco Reschini, Enrico Papaleo, Massimo Candiani, Edgardo Somigliana, Paola Viganò
Endometriosis was claimed to negatively affect the intrafollicular environment, hindering oocyte competence. Previous studies evaluated expression levels of cytochrome P450 aromatase (CYP19A) in granulosa and cumulus oophorus cells collected from endometriosis women, but results are controversial. To further investigate the intrafollicular environment whose alteration may potentially disturb ovarian
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Expression of the umami taste receptor T1R1/T1R3 in porcine testis of: Function in regulating testosterone synthesis and autophagy in Leydig cells J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-29 Ting Gong, Qi Mu, Yongjian Xu, Weiyong Wang, Lijie Meng, Xianzhou Feng, Wenjiao Liu, Zheng Ao, Yiyu Zhang, Xiang Chen, Houqiang Xu
Testosterone is a vital male hormone responsible for male sexual characteristics. The taste receptor family 1 subunit 3 (T1R3) regulates testosterone synthesis and autophagy in non-taste cells, and the links with the taste receptor family 1 subunit 1 (T1R1) for umami perception. However, little is known about these mechanisms. Thus, we aimed to determine the relationship between the umami taste receptor
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The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 catalyzes the activation of testosterone J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-28 Imken Oestlund, Jacky Snoep, Lina Schiffer, Martin Wabitsch, Wiebke Arlt, Karl-Heinz Storbeck
Testosterone biosynthesis from its precursor androstenedione is thought to be exclusively catalysed by the 17β-hydroxysteroid dehydrogenases—HSD17B3 in testes, and AKR1C3 in the ovary, adrenal and peripheral tissues. Here we show for the first time that the glucocorticoid activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) can also catalyse the 17β-reduction of androstenedione to testosterone
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Integration of virtual screening of phytoecdysteroids as androgen receptor inhibitors by 3D-QSAR Model, CoMFA, molecular docking and ADMET analysis: An extensive and interactive machine learning J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-25 Nusrat Shafiq, Rabia Zameer, Naila Attiq, Aniqa Moveed, Ariba Farooq, Fazeelat Imtiaz, Shagufta Parveen, Maryam Rashid, Nadia Noor
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Natural isoflavone glabridin targets PI3Kγ as an adjuvant to increase the sensitivity of MDA-MB-231 to tamoxifen and DU145 to paclitaxel J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-19 Hongyan Lin, Dongxuan Ai, Qingqing Liu, Xinling Wang, Qingqing Chen, Zhongbin Hong, Yuheng Tao, Jian Gao, Liqun Wang
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Exposure to artificial ultraviolet-B light mediates alterations on the hepatic transcriptome and vitamin D metabolism in pigs J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-19 Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar-Christiane Fischer, Klaus Wimmers
In the currently prevailing pig husbandry systems, the vitamin D status is almost exclusively dependent on dietary supply. Additional endogenous vitamin D production after exposure to ultraviolet-B (UVB) light might allow the animals to utilize minerals in a more efficient manner, as well as enable the production of functional vitamin D-enriched meat for human consumption. In this study, growing pigs
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The role of vitamin D through SphK1/S1P in the regulation of MS progression J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-18 Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Sphingosine-1-phosphate (S1P) is biologically active lipid, leading to neuroinflammation and macrophage invasion in central nervous system, plays an important role in the development of multiple sclerosis (MS) model in experimental allergic encephalomyelitis (EAE) rats. Vitamin D is observed to be a key factor in regulating cell S1P levels. We detected vitamin D can alleviate the symptoms of EAE rats
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Corrigendum to “Inhibition of heat shock protein 90 rescues glucocorticoid-induced bone loss through enhancing bone formation” J. Steroid Biochem. Mol. Biol. 171 (July) (2017) 236–246 J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-08 Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
Abstract not available
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Comparison of structure-activity relationship for bisphenol analogs in the inhibition of gonadal 3β-hydroxysteroid dehydrogenases among human, rat, and mouse J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-07 Ya Chen, Huina Zhang, Yang Yu, Shaowei Wang, Mengyun Wang, Chengshuang Pan, Qianjin Fei, Huitao Li, Yiyan Wang, Jieqiang Lv, Ren-shan Ge
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Evolutionary history and functional characterization of duplicated G protein-coupled estrogen receptors in European sea bass J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-11-07 Cinta Zapater, Catarina Moreira, Thomas Knigge, Tiphaine Monsinjon, Ana Gómez, Patrícia I.S. Pinto
Across vertebrates, the numerous estrogenic functions are mainly mediated by nuclear and membrane receptors, including the G protein-coupled estrogen receptor (GPER) that has been mostly associated with rapid non-genomic responses. Although Gper-mediated signalling has been characterized in only few fish species, Gpers in fish appear to present more mechanistic functionalities as those of mammals due
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Predicting comorbidities of pregnancy: A comparison between total and free 25(OH)D and their associations with parathyroid hormone J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-10-31 Caroline A. McWhorter, Molly J. Mead, Megan D. Rodgers, Myla D. Ebeling, Judy R. Shary, Mathew J. Gregoski, Danforth A. Newton, John E. Baatz, Bruce W. Hollis, Martin Hewison, Carol L. Wagner
Pregnancy is a unique time when amplified sex steroid concentrations promote an escalation in vitamin D binding protein (DBP) synthesis, associated with increased total vitamin D and metabolites, including 25-hydroxyvitamin D (25(OH)D). Free 25(OH)D concentration increases disproportionately to total 25(OH)D during pregnancy, likely an adaptation to supply the woman and fetus with readily available
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In vitro functional study of fifteen SRD5A2 variants found in Chinese patients and the relation between the SRD5A2 genotypes and phenotypes J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-10-31 Wei Zhang, Bingging Yu, Wei Luo, Bang Sun, Xiaoxia Zhang, Xi Wang, Jiangfeng Mao, Min Nie, Xueyan Wu
The 5α-reductase type 2 (5α-RD2) deficiency is one of the most common etiology of 46, XY disorders of sex development and is caused by pathogenic variants in SRD5A2. Massively parallel sequencing contributes to identification of numerous novel SRD5A2 variants, in vitro functional study could help to determine their pathogenicity. In this study, we aim to present the functional study of fifteen SRD5A2
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BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-10-18 Ran Gu, Fangfang Dai, Chunrong Xiang, Jing Chen, Dongyong Yang, Wei Tan, Zitao Wang, Hua Liu, Yanxiang Cheng
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Maternal vitamin D intakes during pregnancy and child health outcome J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-10-21 Erdenebileg Nasantogtokh, Davaasambuu Ganmaa, Shirchinjav Altantuya, Bayarsaikhan Amgalan, Davaasambuu Enkhmaa
We conducted a follow up of the children in Mongolia whose mothers received one of the three doses of vitamin D (600, 2000, or 4000 IU daily) during pregnancy as part of the randomized, double-blind, clinical trial of vitamin D supplementation to determine their impact on child health to two years. In the parental trial, 119 pregnant women were assigned to 600 IU/day, 121 were assigned 2000 IU/day
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Structural and clinical characterization of CYP11B2 inhibition by dexfadrostat phosphate J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-10-10 Emanuele Pignatti, Jakub Kollar, Evelyn Hafele, Daniela Schuster, Ronald E. Steele, Bruno Vogt, Christoph Schumacher, Michael Groessl
Aldosterone synthase (CYP11B2) represents a promising drug target because its genetic dysregulation is causally associated with cardiovascular disease, its autonomous activity leads to primary aldosteronism, and its deficiency leads to salt wasting syndromes. The serendipitous discovery that the dextro-rotatory stereoisomer of the racemic aromatase (CYP19A1) inhibitor CGS16949A mediates potent CYP11B2
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Development and validation of a liquid chromatography-tandem mass spectrometry assay to quantify plasma 24(S)-hydroxycholesterol and 27-hydroxycholesterol: A new approach integrating the concept of ion ratio J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-10-06 Daniela Rojas, Sérine Benachenhou, Asma Laroui, Amira Abdourahim Aden, Armita Abolghasemi, Luc Galarneau, Taratibu Janvière Irakoze, Rosalie Plantefeve, Sophie Bouhour, Amanda Toupin, François Corbin, Guy Fink, Pierre-Luc Mallet, Artuela Çaku
Accurate quantification of 24(S)-hydroxycholesterol and 27-hydroxycholesterol holds substantial biological significance due to their involvement in pivotal cellular processes, encompassing cholesterol homeostasis, inflammatory responses, neuronal signaling, and their potential as disease biomarkers. The plasma determination of these oxysterols is challenging considering their low concentrations and
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RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-10-06 Kentaro Tsuji, Hirotoshi Kawata, Tomoko Kamiakito, Takeo Nakaya, Akira Tanaka
Castration-resistant prostate cancer (CRPC) is a big challenge in managing prostate cancer patients. The androgen receptor (AR) pathway is a major driver even in CRPC under androgen deprivation. The mechanism in maintaining of the AR pathway under androgen deprivation remains elusive. The recent discovery of biomolecular condensate, a membrane-less intracellular construct formed by liquid-liquid phase
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The oxidation of steroid derivatives by the CYP125A6 and CYP125A7 enzymes from Mycobacterium marinum J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-10-02 Amna Ghith, Stephen G. Bell
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Corrigendum to “Patients treated for male pattern hair loss with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma” [J. Steroid Biochem. Mol. Biol. 146 (2015) 74–79] J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-28 Donatella Caruso, Federico Abbiati, Silvia Giatti, Simone Romano, Letizia Fusco, Guido Cavaletti, Roberto Cosimo Melcangi
Abstract not available
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Serum steroid metabolite profiling by LC-MS/MS in two phenotypic male patients with HSD17B3 deficiency: Implications for hormonal diagnosis J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-22 Yasuko Fujisawa, Yohei Masunaga, Wataru Tanikawa, Shinichi Nakashima, Daisuke Ueda, Shinichiro Sano, Maki Fukami, Hirotomo Saitsu, Takashi Yazawa, Tsutomu Ogata
Although 17β-hydroxysteroid dehydrogenase type 3 (HSD17B3) deficiency is diagnosed when a testosterone/androstenedione (T/A-dione) ratio after human chorionic gonadotropin (hCG) stimulation is below 0.8, this cut-off value is primarily based on hormonal data measured by conventional immunoassay (IA) in patients with feminized or ambiguous genitalia. We examined two 46,XY Japanese patients with undermasculinized
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Identification of cortisol metabolites with LC-MS/MS in plasma, skin mucus, bile and faeces for stress evaluation of farmed Atlantic salmon J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-19 E. Fanjara, G.H. Aas, Y. Cao, V. Kristinova, A. Saeboe (Sæbø), A. Stene
As a stress hormone, cortisol and more recently its metabolites are analysed when assessing fish stress and welfare status, although the exact identity of these metabolites is not clearly defined for the Atlantic salmon. LC-MS/MS techniques, owing to their specificity, sensitivity and ability to simultaneously identify and measure several relevant compounds, can be useful tools for this purpose. Using
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Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-23 Shweta Maurya, Shashank Tripathi, Ajit Singh
Adropin, a highly conserved multifunctional peptide hormone, has a beneficial effect on the maintenance of gluco-lipid homeostasis, endothelial and cardiovascular functions. However, the expression and potential role of adropin in ovarian function are not fully elucidated. The present study aimed to investigate the expression of adropin and GPR19 in the mice ovary during various stages of postnatal
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The effect of acupuncture on oestrogen receptors in rats with benign prostatic hyperplasia J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-19 Liang Pan, Shiyu Su, Yuanyuan Li, Di Liu, Lingyu Shen, Haiying Wang, Jiayu Wen, Hui Hu, Ruwen Zheng
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Involvement of estrogen receptor alpha (ERα) and impairment of steroidogenesis after exposure to tris(2,3-dibromopropyl) isocyanurate (TBC) in mouse spermatogenic (GC-1 spg) cells in vitro J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-12 Anna Tabęcka-Łonczyńska, Piotr Kaczka, Edyta Kaleniuk
Good-quality reproductive cells are essential for reproduction. Endocrine disruptors are widely available in the environment and are known to have an adverse effect on spermatogenesis and steroidogenesis. One of them is tris(2,3-dibromopropyl) isocyanurate (TBC), i.e. one of the novel brominated flame retardants (NBFR). TBC is a widely distributed ingredient used in the production of flame retardants
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Seasonal expressions of the translocator protein (18 kDa), voltage-dependent anion channel, and steroidogenic acute regulatory protein in the scent glands of muskrats (Ondatra zibethicus) J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-16 Wenqian Xie, Qingjing Gao, Pengyu Chen, Haolin Zhang, Yuning Liu, Qiang Weng
Steroidogenesis machinery involves the steroidogenic acute regulatory protein (StAR), which regulates cholesterol transfer within the mitochondria, and the transport of cholesterol via a channel composed of 18-kDa translocator protein (TSPO), the voltage-dependent anion channel (VDAC) plus some accessory proteins. In this study, we investigated the immunolocalizations and expressions of StAR, TSPO
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Global expression analysis of endometrial cancer cells in response to progesterone identifies new therapeutic targets J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-15 Kristina W. Thiel, Andreea M. Newtson, Eric J. Devor, Yuping Zhang, Paige K. Malmrose, Jianling Bi, Haley A. Losh, Suzy Davies, Lane E. Smith, Jamie Padilla, Stephanie M. Leiva, Chad E. Grueter, Patrick Breheny, Christy R. Hagan, Miles A. Pufall, Jason Gertz, Yan Guo, Kimberly K. Leslie
Progesterone prevents development of endometrial cancers through its receptor (PR) although the molecular mechanisms have yet to be fully characterized. In this study, we performed a global analysis of gene regulation by progesterone using human endometrial cancer cells that expressed PR endogenously or exogenously. We found progesterone strongly inhibits multiple components of the platelet derived
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Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-06 Philippe de Médina, Silia Ayadi, Régis Soulès, Bruno Payre, Sandrine Rup-Jacques, Sandrine Silvente-Poirot, Mohammad Samadi, Marc Poirot
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Progesterone control of myometrial contractility J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-06 Oksana Shynlova, Lubna Nadeem, Stephen Lye
During pregnancy, the primary function of the uterus is to be quiescent and not contract, which allows the growing fetus to develop and mature. A uterine muscle layer, myometrium, is composed of smooth muscle cells (SMCs). Before the onset of labor contractions, the uterine SMCs experience a complex biochemical and molecular transformation involving the expression of contraction-associated proteins
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Secosteroid thiosemicarbazides and secosteroid–1,2,4-triazoles as antiproliferative agents targeting breast cancer cells: Synthesis and biological evaluation J. Steroid Biochem. Mol. Biol. (IF 4.1) Pub Date : 2023-09-02 Alexey I. Ilovaisky, Alexander M. Scherbakov, Elena I. Chernoburova, Andrey A. Povarov, Marina A. Shchetinina, Valentina M. Merkulova, Diana I. Salnikova, Danila V. Sorokin, Eugene I. Bozhenko, Igor V. Zavarzin, Alexander O. Terent’ev