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Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase BBA Proteins Proteom. (IF 3.2) Pub Date : 2024-01-13 Shangyi Xu, Pawel Grochulski, Takuji Tanaka
Prolidase (EC 3.4.13.9) is an enzyme that specifically hydrolyzes Xaa-Pro dipeptides into free amino acids. We previously studied kinetic behaviours and solved the crystal structure of wild-type (WT) Lactococcus lactis prolidase (Llprol), showing that this homodimeric enzyme has unique characteristics: allosteric behaviour and substrate inhibition. In this study, we focused on solving the crystal structures
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Biophysical characterization of human-cell-expressed, full-length κI O18/O8, AL-09, λ6a, and Wil immunoglobulin light chains BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-31 Pinaki Misra, Alexander Tischer, Lindsey Lampe, Valeria Pierluissi-Ruiz, Christopher J. Dick, Benoit Bragantini, Nikita Kormshchikov, Matthew Auton, Marina Ramirez-Alvarado
Immunoglobulin light chain (AL) amyloidosis involves the deposition of insoluble monoclonal AL protein fibrils in the extracellular space of different organs leading to dysfunction and death. Development of methods to efficiently express and purify AL proteins with acceptable standards of homogeneity and structural integrity has become critical to understand the in vitro and in vivo aspects of AL protein
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Characterisation of the forest cobra (Naja melanoleuca) venom using a multifaceted mass spectrometric-based approach BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-27 C. Ruth Wang, Alix C. Harlington, Marten F. Snel, Tara L. Pukala
Snake venoms consist of highly biologically active proteins and peptides that are responsible for the lethal physiological effects of snakebite envenomation. In order to guide the development of targeted antivenom strategies, comprehensive understanding of venom compositions and in-depth characterisation of various proteoforms, often not captured by traditional bottom-up proteomic workflows, is necessary
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Methionine gamma lyase: Structure-activity relationships and therapeutic applications BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-24 Samanta Raboni, Serena Faggiano, Stefano Bettati, Andrea Mozzarelli
Methionine gamma lyase (MGL) is a bacterial and plant enzyme that catalyzes the conversion of methionine in methanthiol, 2-oxobutanoate and ammonia. The enzyme belongs to fold type I of the pyridoxal 5′-dependent family. The catalytic mechanism and the structure of wild type MGL and variants were determined in the presence of the natural substrate as well as of many sulfur-containing derivatives. Structure-function
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PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2 BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-23 Marta Montserrat-Gomez, Gergo Gogl, Kendall Carrasco, Stephane Betzi, Fabien Durbesson, Alexandra Cousido-Siah, Camille Kostmann, Dominic J. Essig, Kristian Strømgaard, Søren Østergaard, Xavier Morelli, Gilles Trave, Renaud Vincentelli, Eric Bailly, Jean-Paul Borg
VANGL2 is a core component of the non-canonical Wnt/Planar Cell Polarity signaling pathway that uses its highly conserved carboxy-terminal type 1 PDZ-binding motif (PBM) to bind a variety of PDZ proteins. In this study, we characterize and quantitatively assess the largest VANGL2 PDZome-binding profile documented so far, using orthogonal methods. The results of our holdup approach support VANGL2 interactions
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Propagation of conformational instability in FK506-binding protein FKBP12 BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-23 David M. LeMaster, Qamar Bashir, Griselda Hernández
FKBP12 is the archetype of the FK506 binding domains that define the family of FKBP proteins which participate in the regulation of various distinct physiological signaling processes. As the drugs FK506 and rapamycin inhibit many of these FKBP proteins, there is need to develop therapeutics which exhibit selectivity within this family. The long β4-β5 loop of the FKBP domain is known to regulate transcriptional
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FunPredCATH: An ensemble method for predicting protein function using CATH BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-19 Joseph Bonello, Christine Orengo
Motivation The growth of unannotated proteins in UniProt increases at a very high rate every year due to more efficient sequencing methods. However, the experimental annotation of proteins is a lengthy and expensive process. Using computational techniques to narrow the search can speed up the process by providing highly specific Gene Ontology (GO) terms. Methodology We propose an ensemble approach
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BthTX-I, a phospholipase A2-like toxin, is inhibited by the plant cinnamic acid derivative: chlorogenic acid BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-21 Fábio Florença Cardoso, Guilherme Henrique Marchi Salvador, Walter Luís Garrido Cavalcante, Maeli Dal-Pai, Marcos Roberto de Mattos Fontes
Snakebite is a significant health concern in tropical and subtropical regions, particularly in Africa, Asia, and Latin America, resulting in more than 2.7 million envenomations and an estimated one hundred thousand fatalities annually. The Bothrops genus is responsible for the majority of snakebite envenomings in Latin America and Caribbean countries. Accidents involving snakes from this genus are
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Classification of binding property of amyloid β to lipid membranes: Membranomic research using quartz crystal microbalance combined with the immobilization of lipid planar membranes BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-19 Toshinori Shimanouchi, Miki Iwamura, Yasuhiro Sano, Keita Hayashi, Minoru Noda, Yukitaka Kimura
A biomembrane-related fibrillogenesis of Amyloid β from Alzheimer’ disease (Aβ) is closely related to its accumulation behavior. A binding property of Aβ peptides from Alzheimer’ disease to lipid membranes was then classified by a quartz crystal microbalance (QCM) method combined with an immobilization technique using thiol self-assembled membrane. The accumulated amounts of Aβ, Δfmax, was determined
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Kinetic characterization of the N-terminal domain of Malonyl-CoA reductase BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-18 Mirela Tkalcic Cavuzic, Grover L. Waldrop
Climate change is driving a search for environmentally safe methods to produce chemicals used in ordinary life. One such molecule is 3-hydroxypropionic acid, which is a platform industrial chemical used as a precursor for a variety of other chemical end products. The biosynthesis of 3-hydroxypropionic acid can be achieved in recombinant microorganisms via malonyl-CoA reductase in two separate reactions
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Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-07 Ivan R. Moraes, Hamine C. de Oliveira, Marcos R.M. Fontes
NEIL glycosylases, including NEIL1, NEIL2, and NEIL3, play a crucial role in the base excision DNA repair pathway (BER). The classical importin pathway mediated by importin α/β and cargo proteins containing nuclear localization sequences (NLS) is the most common transport mechanism of DNA repair proteins to the nucleus. Previous studies have identified putative NLSs located at the C-terminus of NEIL3
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Crystal structure and interconversion of monomers and domain-swapped dimers of the walnut tree phytocystatin BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-12-04 Gisele Alvarenga Simpson, Isabela Fernandes Rezende, Alencar da Silva Peixoto, Igor Barbosa de Oliveira Soares, João Alexandre Ribeiro Gonçalves Barbosa, Sônia Maria de Freitas, Napoleão Fonseca Valadares
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Paradoxical effects on ice nucleation are intrinsic to a small winter flounder antifreeze protein BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-11-11 Xing Jian Chang, Dane C. Sands, Kathryn Vanya Ewart
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A dissected non-ribosomal peptide synthetase maintains activity BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-11-10 Amanda J. Platt, Shae Padrick, Amy T. Ma, Joris Beld
Non-ribosomal peptide synthetases (NRPSs) generate chemically complex compounds and their modular architecture suggests that changing their domain organization can predictably alter their products. Ebony, a small three-domain NRPS, catalyzes the formation of β-alanine containing amides from biogenic amines. To examine the necessity of interdomain interactions, we modeled and docked domains of Ebony
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Structural conservation in the glutathione binding in Sphingomonas sp. glutaredoxin Grx3 and variations for cold adaptation BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-11-05 Trang Van Tran, Hoa Nguyen, Luyen Vu, ChangWoo Lee
Glutaredoxin 3 (Grx3), a redox protein with a thioredoxin-fold structure, maintains structural integrity and glutathione (GSH) binding capabilities across varying habitat temperatures. The cis-Pro loop, essential for GSH binding, relies on the Arg-Asp salt bridge (α2-α3) and Gln-His hydrogen bond (β3-β4) for its conformation. In some psychrophilic Grx3 variants, Arg in α2 is replaced with Tyr, and
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Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-10-19 Michael J. O'Brien, Athar Ansari
Although TFIIB is widely regarded as an initiation factor, recent reports have implicated it in multiple aspects of eukaryotic transcription. To investigate the broader role of TFIIB in transcription, we performed quantitative proteomic analysis of yeast TFIIB. We purified two different populations of TFIIB; one from soluble cell lysate, which is not engaged in transcription, and the other from the
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Structure of the Borrelia burgdorferi ATP-dependent metalloprotease FtsH in its functionally relevant hexameric form BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-10-16 Kalvis Brangulis, Laura Drunka, Inara Akopjana, Kaspars Tars
ATP-dependent proteases FtsH are conserved in bacteria, mitochondria, and chloroplasts, where they play an essential role in degradation of misfolded/unneeded membrane and cytosolic proteins. It has also been demonstrated that the FtsH homologous protein BB0789 is crucial for mouse and tick infectivity and in vitro growth of the Lyme disease-causing agent Borrelia burgdorferi. This is not surprising
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Structural characterization of the human DjC20/HscB cochaperone in solution BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-10-21 Amanda Lais de Souza Coto, Arthur Alexandre Pereira, Sabrina Dorta Oliveira, Milene Nobrega de Oliveira Moritz, Arthur Moraes Franco da Rocha, Paulo Roberto Dores-Silva, Noeli Soares Melo da Silva, Ana Rita de Araújo Nogueira, Lisandra Marques Gava, Thiago Vagas Seraphim, Júlio César Borges
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Antibodies and α-synuclein: What to target against Parkinson's Disease? BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-09-30 Daniel E. Otzen
Parkinson's Disease (PD) is strongly linked to the aggregation of the protein α-synuclein (α-syn), an intrinsically disordered protein. However, strategies to combat PD by targeting the aggregation of α-syn are challenged by the multiple types of aggregates formed both in vivo and in vitro, the potential influence of chemical modifications and the as yet unresolved question of which aggregate types
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Calcium binding of AtCBL1: Structural and functional insights BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-09-25 Alexandra Bork, Sander H.J. Smits, Lutz Schmitt
CBL1 is an EF hand Ca2+ binding protein from A. thaliana that is involved in the detection of cellular Ca2+ signals and the downstream signal transmission by interaction with the protein kinase CIPK23. So far, the structure and calcium ion binding affinities of CBL1 remain elusive. In this study it was observed that CBL1 tends to form higher oligomeric states due to an intrinsic hydrophobicity and
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Bacteriophage-encoded chaperonins stimulate prion protein fibrillation in an ATP-dependent manner BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-09-20 Evgeniia V. Leisi, Andrey V. Moiseenko, Sofia S. Kudryavtseva, Denis V. Pozdyshev, Vladimir I. Muronetz, Lidia P. Kurochkina
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The regulation of RGLG2-VWA by Ca2+ ions BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-09-19 MeiLing Zhang, JiaXiang Zhang, Yan Liang, ShiCheng Tian, ShuYang Xie, Tong Zhou, Qin Wang
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Importance of aspartate 4 in the Mg2+ dependent regulation of Leishmania major PAS domain-containing phosphoglycerate kinase BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-09-17 Gaurab Chowdhury, Saroj Biswas, Yuthika Dholey, Puja Panja, Sumit Das, Subrata Adak
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Rational design engineering of a more thermostable Sulfurihydrogenibium yellowstonense carbonic anhydrase for potential application in carbon dioxide capture technologies BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-09-15 Shima Ghaedizadeh, Majid Zeinali, Bahareh Dabirmanesh, Behnam Rasekh, Khosrow Khajeh, Ali Mohammad Banaei-Moghaddam
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Enzymatic and biophysical characterization of a novel modular cellulosomal GH5 endoglucanase multifunctional from the anaerobic gut fungus Piromyces finnis BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-09-09 Viviane Brito Andrade, Geizecler Tomazetto, Dnane Vieira Almeida, Robson Tramontina, Fabio Marcio Squina, Wanius Garcia
Cellulases from anaerobic fungi are enzymes less-studied biochemically and structurally than cellulases from bacteria and aerobic fungi. Currently, only thirteen GH5 cellulases from anaerobic fungi were biochemically characterized and two crystal structures were reported. In this context, here, we report the functional and biophysical characterization of a novel multi-modular cellulosomal GH5 endoglucanase
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Effect of flavonoids on the destabilization of α-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-08-25 Ishrat Jahan, Aziz Ahmad, Shashank Deep
The second most prevalent neurodegenerative disease, Parkinson's disease (PD), is caused by the accumulation and deposition of fibrillar aggregates of the α-Syn into the Lewy bodies. To create a potent pharmacological candidate to destabilize the preformed α-Syn fibril, it is important to understand the precise molecular mechanism underlying the destabilization of the α-Syn fibril. Through molecular
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Structural and functional characterisation of Tst2, a novel TRPV1 inhibitory peptide from the Australian sea anemone Telmatactis stephensoni BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-08-26 Khaled A. Elnahriry, Dorothy C.C. Wai, Lauren M. Ashwood, Muhammad Umair Naseem, Tibor G. Szanto, Shaodong Guo, Gyorgy Panyi, Peter J. Prentis, Raymond S. Norton
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Heterotypic liquid-liquid phase separation of tau and α-synuclein: Implications for overlapping neuropathologies BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-08-18 Nahuel N. Foressi, Leandro Cruz Rodríguez, M. Soledad Celej
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Biomolecular NMR in the AI-assisted structural biology era: Old tricks and new opportunities BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-08-11 Theodoros K. Karamanos, Stephen Matthews
Over the last 40 years nuclear magnetic resonance (NMR) spectroscopy has established itself as one of the most versatile techniques for the characterization of biomolecules, especially proteins. Given the molecular size limitations of NMR together with recent advances in cryo-electron microscopy and artificial intelligence-assisted protein structure prediction, the bright future of NMR in structural
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Deep learning-based method for predicting and classifying the binding affinity of protein-protein complexes BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-08-09 Rahul Nikam, Kumar Yugandhar, M. Michael Gromiha
Protein-protein interactions (PPIs) play a critical role in various biological processes. Accurately estimating the binding affinity of PPIs is essential for understanding the underlying molecular recognition mechanisms. In this study, we employed a deep learning approach to predict the binding affinity (ΔG) of protein-protein complexes. To this end, we compiled a dataset of 903 protein-protein complexes
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The protease associated (PA) domain in ScpA from Streptococcus pyogenes plays a role in substrate recruitment BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-08-09 Sophie McKenna, Frances Aylward, Xeni Miliara, Rikin J. Lau, Camilla Berg Huemer, Sean P. Giblin, Kristin K. Huse, Mingyang Liang, Lucy Reeves, Max Pearson, Yingqi Xu, Sarah L. Rouse, James E. Pease, Shiranee Sriskandan, Todd F. Kagawa, Jakki Cooney, Stephen Matthews
Annually, over 18 million disease cases and half a million deaths worldwide are estimated to be caused by Group A Streptococcus. ScpA (or C5a peptidase) is a well characterised member of the cell enveleope protease family, which possess a S8 subtilisin-like catalytic domain and a shared multi-domain architecture. ScpA cleaves complement factors C5a and C3a, impairing the function of these critical
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Characterization of E121K mutation of D-amino acid oxidase – Insights into mechanisms leading to amyotrophic lateral sclerosis BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-08-07 Upma Dave, Shumayila Khan, James Gomes
D-amino acid oxidase (DAO) maintains the intracellular d-serine level which modulates the activity of the N-methyl-d-aspartate receptor and its dysfunction has been linked to several neurodegenerative disorders. In targeted next-generation sequencing study by our group, E121K mutation in DAO was associated with amyotrophic lateral sclerosis (ALS) in patients from India. However, variations in molecular
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Reactive architecture profiling with a methyl acyl phosphate electrophile BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-08-01 Laura C. McGary, Gemma L. Regan, Stephen L. Bearne
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Distinct dynamical features of plasmodial and human HSP70-HSP110 highlight the divergence in their chaperone-assisted protein folding BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-07-27 Aradhya Tripathi, Sara Del Galdo, Balasubramanian Chandramouli, Niti Kumar
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Bothrops atrox venom: Biochemical properties and cellular phenotypes of three highly toxic classes of toxins BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-07-12 Leticia Lopes-de-Souza, Fernanda Costal-Oliveira, Carolina Rego Rodrigues, Stephanie Stransky, Thamyres C.S. de Assis, Camila Liberato, Dan Vivas-Ruiz, Armando Yarleque Chocas, Clara Guerra-Duarte, Vania M.M. Braga, Carlos Chávez-Olortegui
Snake venoms have a complex mixture of compounds that are conserved across species and act synergistically, triggering severe local and systemic effects. Identification of the toxin classes that are most damaging to cell homeostasis would be a powerful approach to focus on the main activities that underpin envenomation. Here, we focus on the venom of Bothrops atrox, snake responsible for most of the
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Modulation of the conformation, fibrillation, and fibril morphologies of human brain α-, β-, and γ-synuclein proteins by the disaccharide chemical chaperone trehalose BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-07-09 Manish K. Jain, Rajiv Bhat
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The Fe and Zn cofactor dilemma BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-06-21 Jiahua Chen, Logan A. Calderone, Luying Pan, Trent Quist, Maria-Eirini Pandelia
Fe and Zn ions are essential enzymatic cofactors across all domains of life. Fe is an electron donor/acceptor in redox enzymes, while Zn is typically a structural element or catalytic component in hydrolases. Interestingly, the presence of Zn in oxidoreductases and Fe in hydrolases challenge this apparent functional dichotomy. In hydrolases, Fe either substitutes for Zn or specifically catalyzes certain
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The structural and functional consequences of melatonin and serotonin on human αB-crystallin and their dual role in the eye lens transparency BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-06-16 Mona Nourazaran, Reza Yousefi, Faezeh Moosavi-Movahedi, Farhad Panahi, Jun Hong, Ali A. Moosavi-Movahedi
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Oligomeric state of the N-terminal domain of DnaT for replication restart in Escherichia coli BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-06-14 Shogo Inoue, Yohei Ikeda, Saki Fujiyama, Tadashi Ueda, Yoshito Abe
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Comparison of force fields to study the zinc-finger containing protein NPL4, a target for disulfiram in cancer therapy BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-05-24 Simone Scrima, Matteo Tiberti, Ulf Ryde, Matteo Lambrughi, Elena Papaleo
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The effect of denaturants on protein thermal stability analyzed through a theoretical model considering multiple binding sites BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-05-18 M. Ines Burgos, Sergio A. Dassie, Gerardo D. Fidelio
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Production of recombinant lytic polysaccharide monooxygenases and evaluation effect of its addition into Aspergillus fumigatus var. niveus cocktail for sugarcane bagasse saccharification BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-05-08 Aline Larissa Gonçalves, Paula Macedo Cunha, Awana da Silva Lima, Júlio César dos Santos, Fernando Segato
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Metaviromics analysis of marine biofilm reveals a glycoside hydrolase endolysin with high specificity towards Acinetobacter baumannii BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-05-05 Georgios E. Premetis, Nikolaos D. Georgakis, Angeliki Stathi, Nikolaos E. Labrou
Multidrug-resistant (MDR) bacteria are a growing threat to the public health. Among them, the Gram-negative Acinetobacter baumannii is considered today as the most dangerous MDR pathogen. Phage-derived endolysins are peptidoglycan (PG) hydrolytic enzymes that can function as effective tools in the fight against MDR bacteria. In the present work, the viral diversity of a marine environmental sample
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Thermodynamic modulation of folding and aggregation energy landscape by DNA binding of functional domains of TDP-43 BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-04-13 Divya Patni, Santosh Kumar Jha
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Engineering of conserved residues near antibody heavy chain complementary determining region 3 (HCDR3) improves both affinity and stability BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-04-13 Merve Arslan, Tuğçe Uluçay, Seyit Kale, Sibel Kalyoncu
Affinity and stability are crucial parameters in antibody development and engineering approaches. Although improvement in both metrics is desirable, trade-offs are almost unavoidable. Heavy chain complementarity determining region 3 (HCDR3) is the best-known region for antibody affinity but its impact on stability is often neglected. Here, we present a mutagenesis study of conserved residues near HCDR3
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Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-04-13 Santosh Devi, Dushyant Kumar Garg, Rajiv Bhat
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The molecular basis of the antidepressant action of the magic mushroom extract, psilocin BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-04-03 Ali Asghar Hakami Zanjani, Teresa Quynh Tram Nguyen, Luise Jacobsen, Himanshu Khandelia
Magic mushrooms, and their extract psilocybin, are well-known for their psychedelic properties and recreational use. Psilocin, the bio-active form of psilocybin, can potentially treat various psychiatric diseases. Psilocin putatively exerts its psychedelic effect as an agonist to the serotonin 2A receptor (5-HT2AR), which is also the receptor for the neurological hormone serotonin. The two key chemical
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The effect of pH and nitrite on the haem pocket of GLB-33, a globin-coupled neuronal transmembrane receptor of Caenorhabditis elegans BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-03-31 Niels Van Brempt, Roberta Sgammato, Quinten Beirinckx, Dietmar Hammerschmid, Frank Sobott, Sylvia Dewilde, Luc Moens, Wouter Herrebout, Christian Johannessen, Sabine Van Doorslaer
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Corrigendum to “The explorations of dynamic interactions of paxillin at the focal adhesions” [Biochimica et Biophysica Acta(BBA) - Proteins and Proteomics 1870/10 (2022) 140825] BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-03-14 Aziz ur Rehman Aziz, Sha Deng, Yuhang Jin, Na Li, Zhengyao Zhang, Xiaohui Yu, Bo Liu
Abstract not available
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Two different alanine dehydrogenases from Geobacillus kaustophilus: Their biochemical characteristics and differential expression in vegetative cells and spores BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-03-12 Miku Maeno, Taketo Ohmori, Daiki Nukada, Haruhiko Sakuraba, Takenori Satomura, Toshihisa Ohshima
Two putative alanine dehydrogenase (AlaDH) genes (GK2752 and GK3448) were found in the genome of a thermophilic spore-forming bacterium, Geobacillus kaustophilus. The amino acid sequences deduced from the two genes showed mutually high homology (71%), and the phylogenetic tree based on the amino acid sequences of the two putative AlaDHs and the homologous proteins showed that the two putative AlaDH
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Beta-KTx14.3, a scorpion toxin, blocks the human potassium channel KCNQ1 BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-03-12 Gustavo Titaux-Delgado, Andrea Estefanía Lopez-Giraldo, Elisa Carrillo, Luis Fernando Cofas-Vargas, Luis Enrique Carranza, Estuardo López-Vera, Enrique García-Hernández, Federico del Rio-Portilla
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Citrus flavanone metabolites significantly modulate global proteomic profile in pancreatic β-cells under high-glucose-induced metabolic stress BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-01-30 Layanne Nascimento Fraga, Dragan Milenkovic, Sara Lima Anacleto, Michelle Salemi, Franco M. Lajolo, Neuza M.A. Hassimotto
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Molecular dynamics simulations suggest Thiosemicarbazones can bind p53 cancer mutant R175H BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-01-30 Tanushree Das, Chaitali Mukhopadhyay
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Cd-induced cytosolic proteome changes in the cyanobacterium Anabaena sp. PCC7120 are mediated by LexA as one of the regulatory proteins BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-01-27 Akanksha Srivastava, Arvind Kumar, Subhankar Biswas, Vaibhav Srivastava, Hema Rajaram, Yogesh Mishra
LexA, a well-characterized transcriptional repressor of SOS genes in heterotrophic bacteria, has been shown to regulate diverse genes in cyanobacteria. An earlier study showed that LexA overexpression in a cyanobacterium, Anabaena sp. PCC7120 reduces its tolerance to Cd stress. This was later shown to be due to modulation of photosynthetic redox poising by LexA under Cd stress. However, due to the
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Elucidating the inhibitory effects of rationally designed novel hexapeptide against hen egg white lysozyme fibrillation at acidic and physiological pH BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-01-21 Amit Mitra, Nandini Sarkar
Inhibition of highly ordered cross-β-sheet-rich aggregates of misfolded amyloid proteins using rationally designed sequence-based short peptides is a promising therapeutic strategy for the treatment of neurodegenerative diseases. Here, we have explored the anti-amyloidogenic potency of a rationally designed hexapeptide (Tyr-Pro-Gln-Ile-Pro-Asn) on in vitro hen egg white lysozyme (HEWL) amyloid fibril
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Structural characterization of the type I-B CRISPR Cas7 from Thermobaculum terrenum BBA Proteins Proteom. (IF 3.2) Pub Date : 2023-01-20 Pil-Won Seo, Do-Heon Gu, Ji-Won Kim, Jun-Hong Kim, Suk-Youl Park, Jeong-Sun Kim
Clustered regularly interspaced short palindromic repeats (CRISPR) in many prokaryotes functions as an adaptive immune system against mobile genetic elements. A heterologous ribonucleoprotein silencing complex composed of CRISPR-associated (Cas) proteins and a CRISPR RNA (crRNA) neutralizes the incoming mobile genetic elements. The type I and III silencing complexes commonly include a protein-helical