样式: 排序: IF: - GO 导出 标记为已读
-
Downregulation of miR-337-3p in hypoxia/reoxygenation neuroblastoma cells increases KCTD11 expression J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-18 Lin Zhu, Yi-Juan Xin, Mu He, Jun Bian, Xiao-Li Cheng, Rui Li, Jin-Jie Li, Juan Wang, Jia-Yun Liu, Liu Yang
Neurodegeneration is linked to the progressive loss of neural function and is associated with several diseases. Hypoxia is a hallmark in many of these diseases, and several therapies have been developed to treat this disease, including gene expression therapies that should be tightly controlled to avoid side effects. Cells experiencing hypoxia undergo a series of physiological responses that are induced
-
N-allyl quinoxaline derivative exhibited potent and selective cytotoxicity through EGFR/VEGFR-mediated apoptosis: In vitro and in vivo studies J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-16 Mohamed S. Nafie, Mohab A. Ali, Magdy M. Youssef
The cytotoxic activity, EGFR/VEGFR2 target inhibition, apoptotic activity, RT-PCR gene expression, in vivo employing a solid-Ehrlich carcinoma model, and in silico investigations for highlighting the binding affinity of eight quinoxaline derivatives were tested for anticancer activities. The results showed that compound 8 (N-allyl quinoxaline) had potent cytotoxicity against A594 and MCF-7 cancer cells
-
Novel furan chalcone modulates PHD‐2 induction to impart antineoplastic effect in mammary gland carcinoma J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-16 Shubham Rastogi, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Sunil Kumar Singh, Alok Mukerjee, Gaurav Kaithwas
-
miR‐200a‐3p inhibits the PDGF‐BB‐induced proliferation of VSMCs by affecting their phenotype‐associated proteins J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-16 Rui‐Yuan Zeng, Hong‐Yi Jin, Yong‐Bo Peng, Wen‐Jun Wang, Yuan‐Ping Cao, Han‐Zhi Peng, Zhi‐Cong Qiu, Song‐Qing Lai, Li Wan
Accumulating evidence shows that the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) can significantly affect the long‐term prognosis of coronary artery bypass grafting. This study aimed to explore the factors affecting the proliferation, migration, and phenotypic transformation of VSMCs. First, we stimulated VSMCs with different platelet‐derived growth factor‐BB (PDGF‐BB)
-
Association of long noncoding RNA H19 rs2839698 C/T with hepatitis B virus infection and hepatocellular carcinoma risk J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-14 Tarek K. Motawi, Amira E. Mady, Mostafa Elhelbawy, Roba M. Talaat, Nancy N. Shahin
-
Excess iron accumulation mediated senescence in diabetic kidney injury J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-14 Xueer Cheng, Yanyan Li, Li Chen, Chunjie Jiang, Shufen Peng, Ping Yao, Yuhan Tang
-
-
Exome sequencing identifies ADGRG4 G‐protein‐coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-11 Minerva Sharma, Sonali Verma, Shabab Lalit Angurana, Ziya Tufail, Vanshika Bhagat, Sonia Nagyal, Rajeshwer Singh Jamwal, Bhawani Sharma, Ruchi Shah, Audesh Bhat, Gresh Chander, Rakesh Kumar
-
CLDN6 inhibited cellular biological function of nonsmall cell lung cancer cells through suppressing aerobic glycolysis via the RIP1/ASK1/JNK axis J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-11 Hua Guo, Jianying Li, Yu Dong, Humei Gao, Peng Wang
Claudin‐6 (CLDN6) has been extensively studied in different tumors to date. However, in the case of nonsmall cell lung cancer (NSCLC), CLDN6 has a largely unknown role and molecular mechanism. We detected the expression of CLDN6 in NSCLC tissues and cells using reverse transcription‐quantitative polymerase chain reaction (PCR) and western blot assays. A gain‐of‐function experiment was performed to
-
Spinal microglial M1 polarization contributes paclitaxel‐induced neuropathic pain by triggering cells necroptosis J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-09 Ma Dong Yang, Wang Ming Jie, Li Hui Zhou, Li Zhao, Liu Xin, Wang Xiu Li, Zhao Shuang
-
Pyridostigmine attenuated high‐fat‐diet induced liver injury by the reduction of mitochondrial damage and oxidative stress via α7nAChR and M3AChR J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-08 Runqing Xue, Qing Wu, Lulu Guo, Dan Ye, Qing Cao, Meng Zhang, Yushan Xian, Minchun Chen, Kangkang Yan, Jie Zheng
Obesity is a major cause of nonalcohol fatty liver disease (NAFLD), which is characterized by hepatic fibrosis, lipotoxicity, inflammation, and apoptosis. Previous studies have shown that an imbalance in the autonomic nervous system is closely related to the pathogenesis of NAFLD. In this study, we investigated the effects of pyridostigmine (PYR), a cholinesterase (AChE) inhibitor, on HFD‐induced liver
-
Tempol alleviates acute lung injury by affecting glutathione synthesis through Nrf2 and inhibiting ferroptosis in lung epithelial cells J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-08 Li Ai, Ran Li, Xiaona Wang, Zhijuan Liu, Yongxia Li
-
Lycopene prevents cell death in NRK‐52E cells by inhibition of high glucose‐activated DNA damage and apoptotic, autophagic, and necrotic pathways J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-06 Ayşe Usta, Veysel Yüksek, Sedat Çetin, Semiha Dede
This study aims to investigate the effects of lycopene on apoptotic, autophagic, and necrotic pathways, oxidative status, and DNA damage in diabetic nephropathy at the molecular level. The sample of the study includes seven groups: lycopene (L), high glucose (G), high glucose + lycopene (GL), and control (C) groups tested at 12 and 24 h. The expression levels of genes in oxidative, apoptotic, autophagic
-
Integrated analysis of ceRNA‐miRNA changes in paraquat‐induced pulmonary epithelial‐mesenchymal transition via high‐throughput sequencing J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-06 Zhiyu Ma, Nana Wang, Tingting Meng, Ruoying Zhang, Yang Huang, Tiegang Li
Recent studies have shown that epithelial‐mesenchymal transition (EMT) plays an important role in paraquat (PQ)‐induced tissue fibrosis, which is the main cause of death in patients with PQ poisoning. However, no effective treatment for pulmonary interstitial fibrosis caused by PQ poisoning exists. It is of great significance for us to find new therapeutic targets through bioinformatics in PQ‐induced
-
Cardioprotective effects of p‐coumaric acid on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance in isoproterenol‐induced experimental myocardial infarction J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-05 Stanely Mainzen Prince Ponnian, Shervin Prince Stanely, Abhro Jyoti Roy
-
Cadmium neurotoxicity and therapeutic strategies J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-03-04 Shuangquan Wen, Liang Wang
-
l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-17 Swagata Pal, Shaheen Wasil Kabeer, Shivam Sharma, Kulbhushan Tikoo
-
Exosomal miR‐93 derived from hepatocellular carcinoma cell promotes the sorafenib resistance of hepatocellular carcinoma through PTEN/PI3K/Akt pathway J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-20 Yuanpeng Bao, Song Xu, Junjing Zhou, Chongyong Zhao, Saimin Dai, Yong Zhang, Min Rao
-
Bisphenol A regulates bladder cells responses via control of G2/M‐phase cell cycle, apoptotic signaling, MAPK pathway, and transcription factor‐associated MMP modulation J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-19 Jun‐Hui Song, Byungdoo Hwang, Solbi Park, Soobin Kim, Dong‐Ho Kim, Yung Hyun Choi, Wun‐Jae Kim, Sung‐Kwon Moon
Bisphenol A (BPA), an exogenous endocrine‐disrupting chemical, is widely used to produce polycarbonate plastics. The widely used BPA has been detected in human urine samples, raising public anxiety about the detrimental effects of BPA on the bladder. In this study, we explored regulatory mechanisms for the adverse effects of BPA in human bladder BdFC and T24 cells. BPA induced extrinsic and intrinsic
-
Phenothiazines: Nrf2 activation and antioxidant effects J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-19 Melford C. Egbujor, Paolo Tucci, Brigitta Buttari, David C. Nwobodo, Pietro Marini, Luciano Saso
-
Protective effect of colchicine on albumin glycation and cellular oxidative stress: Insights into diabetic cardiomyopathy J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-19 Muskan Rajkumar Thakur, Rashmi Santosh Tupe
-
Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-14 Bharti Yadav, Sharanjot Kaur, Anuradha Yadav, Harkomal Verma, Swastitapa Kar, Binit Kumar Sahu, Kumari Riya Pati, Bibekanada Sarkar, Monisha Dhiman, Anil Kumar Mantha
-
Retraction: ‘Enhanced anticancer potency of doxorubicin in combination with curcumin in gastric adenocarcinoma’ J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-14
Retraction: ‘Enhanced anticancer potency of doxorubicin in combination with curcumin in gastric adenocarcinoma’ by Fatemeh Firouzi Amoodizaj, Sevda Baghaeifar, Elham Taheri, Mahdieh Farhoudi Sefidan Jadid, Maryam Safi, Nasrin Seyyed Sani, Saba Hajazimian, Alireza Isazadeh, Dariush Shanehbandi, J Biochem Mol Toxicol 2020, 34:e22486.
-
NDC1 promotes hepatocellular carcinoma tumorigenesis by targeting BCAP31 to activate PI3K/AKT signaling J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-07 Ya-ping Liu, Gang Guo, Mudan Ren, Ya-rui Li, Dan Guo, Jun-jun She, Shui-xiang He
Hepatocellular carcinoma (HCC) is among the world's worst malignancies. Nuclear division cycle 1 (NDC1) is an essential membrane-integral nucleoporin, found in this study to be significantly increased in primary HCC. A multivariate analysis revealed that higher NDC1 expression was linked to worse outcome in HCC patients. Mouse xenograft tumors overexpressing NDC1 grew rapidly, and HCC cells overexpressing
-
LINC00624 affects hepatocellular carcinoma proliferation and apoptosis through the miR-342-3p/DNAJC5 axis J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-30 Huawei Xu, Peng Shen, Jian Fang, Jihua Jiang, Yinsheng Shi, Pengcheng Xu, Renya Jiang, Zhengfei Wang
-
Biochemical responses and antioxidant defense mechanisms in Channa Striatus exposed to Bisphenol S J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-30 Sini Mohan, Jubi Jacob, Nair Achuthan Malini, Reshma Prabhakar, Roy George Kayalakkakathu
-
Exosome-transported of circ_0081069 induces SPIN1 production by binding to miR-195-5p to inhibit radiosensitivity in esophageal squamous cell carcinoma J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-02-01 Ting Chai, Junqi Liu, Zongwen Liu, Ruitai Fan
Circ_0081069 plays a key role in tumor growth; however, its effect on radiosensitivity in esophageal squamous cell carcinoma (ESCC) remains unknown. The study is performed to reveal the association of circ_0081069 expression and radiosensitivity in ESCC and the underlying mechanism. Circ_0081069, miR-195-5p, and spindlin 1 (SPIN1) RNA expression were detected by quantitative real-time polymerase chain
-
Effect of vinpocetine against acrylamide-induced nephrotoxicity in rats J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-27 Doaa S. Ibrahim
-
FZD3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the Wnt signaling pathway J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-27 Jie Li, Junqin Zhang, Zhaoping Chu, Hua Han, Yuan Zhang
The occurrence of pelvic organ prolapse (POP) seriously affects women's quality of life. However, the pathogenesis of POP remains unclear. We aimed to clarify the role of Frizzled class receptor 3 (FZD3) in POP. FZD3 expression in the vaginal wall tissues was detected using immunohistochemistry, real-time polymerase chain reaction, and western blot analysis. Then, vaginal wall fibroblasts (VWFs) were
-
Quantitative proteomics study of carnosine effect in an animal model of Western diet-induced nonalcoholic fatty liver disease J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-27 Fernando Moreto, Jéssica Leite Garcia, Ana Lúcia dos Anjos Ferreira, Silvia Radrezza, Mariane Róvero Costa, Guilherme Ribeiro Romualdo, Nubia Alves Grandini, Giancarlo Aldini, Camila Renata Correa, Alfonsina D'Amato
The nonalcoholic fatty liver disease (NAFLD), which is closely related to westernized dietary (WD) patterns, displays a rising epidemiological and economic burden. Since there is no pharmacological therapy approved for this disease, mechanistic studies are warranted. In this work, we investigated the action of carnosine (CAR), a natural dipeptide with several protection roles against oxidative stress
-
Exosomal circ_0037104 derived from Hu-MSCs inhibits cholangiocarcinoma progression by sponging miR-620 and targeting AFAP1 J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-27 Zilin Yuan, Ba Xiong, Lie Liu, Yifan Lu, Yueping Liu, Gang Wang, Yang Qian, Bo Diao, Mingzhong Tu
Exosomes are membrane-enclosed nanovesicles that shuttle active cargoes, such as circular RNAs (circRNAs) and microRNAs (miRNAs), between different cells. Human umbilical cord-derived mesenchymal stem cells (Hu-MSCs) can migrate to tumor sites and exert complex functions throughout tumor progression. In this study, we successfully isolated Hu-MSCs from human umbilical cords based on their surface marker
-
Curcumin inhibits prostate cancer by upregulating miR-483-3p and inhibiting UBE2C J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-24 Wenji Li, Fujun Wang, Xiaoxiang Wang, Wei Xu, Fangmin Liu, Rong Hu, Shanyi Li
Prostate cancer (PCa) is an extremely common genitourinary malignancy among elderly men. Many evidence have shown the efficacy of curcumin (CUR) in inhibiting the progression of PCa. However, the pharmacological function of CUR in PCa is still not quite clear. In this research, CUR was found to suppress the proliferation and enhance the apoptotic rate in in vitro PCa cell models in a dose- and time-dependent
-
Asperuloside alleviates cyclophosphamide-induced myelosuppression by promoting AMPK/mTOR pathway-mediated autophagy J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-24 Hong Che, Linlin Li, Bingjie Zhao, Lian Hu, Li Xiao, Peijia Liu, Songshan Liu, Zhufa Hou
Cyclophosphamide (CTX) is a common anticancer chemotherapy drug, and myelosuppression is the most common serious side effect. Asperuloside (ASP), the active component of Hedyotis diffusa Willd., may have the effect of ameliorating chemotherapy-induced myelosuppression. This study aimed to explore the effect and possible mechanism of ASP on CTX-induced myelosuppression. Male SPF C57BL/6 mice were randomly
-
18β-Glycyrrhetinic acid exerts cardioprotective effects against BPA-induced cardiotoxicity through antiapoptotic and antioxidant mechanisms J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-24 Ibrahim Bayav, Ekrem Darendelioğlu, Cuneyt Caglayan
-
Activation of autophagy promotes the inhibitory effect of curcumin analog EF-24 against MDA-MB-231 cancer cells J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-19 Yin-Yin Zhao, Jun Li, Hao-Qi Wang, Hao-Bo Zheng, Shi-Wei Ma, Guang-Zhou Zhou
-
Protective effects of naringin on colistin-induced damage in rat testicular tissue: Modulating the levels of Nrf-2/HO-1, AKT-2/FOXO1A, Bax/Bcl2/Caspase-3, and Beclin-1/LC3A/LC3B signaling pathways J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-21 Nazım Abdülkadir Kankılıç, Hasan Şimşek, Nurhan Akaras, Cihan Gür, Mustafa İleritürk, Sefa Küçükler, Serkan A. Akarsu, Fatih M. Kandemir
-
Nrf2 activation by hydroxytyrosol and dimethyl fumarate ameliorates skin tissue repair in high-fat diet-fed mice by promoting M2 macrophage polarization and normalizing inflammatory response and oxidative damage J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-22 Regina Viana de Carvalho Faria, Matheus Silva Duarte, Jeane de Souza Nogueira, Bianca Martins Gregório, Bruna Romana-Souza
-
Tanshinone IIA regulates CCl4 induced liver fibrosis in C57BL/6J mice via the PI3K/Akt and Nrf2/HO-1 signaling pathways J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-21 Qingqing Li, Dongrui Huang, Wenjing Liao, Xinyue Su, Jin Li, Jinwei Zhang, Meng Fang, Yuwei Liu
Chronic liver diseases caused by various factors may develop into liver fibrosis (LF). Early stage of LF could be reversible. Tanshinone IIA (Tan IIA), an extract from Salvia miltiorrhiza, has been reported to be hepatoprotective. However, the potential targets and mechanism of Tan IIA in the treatment of LF are still unclear. Our study aims at the anti-LF mechanism of Tan IIA through network pharmacological
-
Novel insights on the probable mechanism associated with histamine oral model-inducing neuropathological and behavioral toxicity in rats J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-21 Wafaa A. Mohamed, Eman I. Hassanen, Hayam A. Mansour, Marwa A. Ibrahim, Rehab A. Azouz, Mahmoud A. Mahmoud
Histamine (HIS) is an important chemical mediator that causes vasodilation and contributes to anaphylactic reactions. Recently, HIS is an understudied neurotransmitter in the central nervous system, and its potential role in neuroinflammation and neurodegeneration is a critical area of research. So, the study's goal is to investigate the consequences of repeated oral intake of HIS on the rat's brain
-
New mode of action of curcumin on prostate cancer cells: Modulation of endoplasmic reticulum-associated degradation mechanism and estrogenic signaling J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-10 Yalcin Erzurumlu, Hatice Kubra Dogan, Deniz Catakli
-
The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-05 Yanyan Liu, Yingjian Wang, Mengsi Hu, Shoufang Xu, Feiyu Jiang, Yetao Han, Zhiwei Liu
-
Melatonin attenuates liver injury in arsenic-treated rats: The potential role of the Nrf2/HO-1, apoptosis, and miR-34a/Sirt1/autophagy pathways J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-03 Samira Barangi, Soghra Mehri, Zahra Moosavi, Fatemeh Yarmohammadi, A. Wallace Hayes, Gholamreza Karimi
Arsenic is a toxic metalloid found in the environment in different organic and inorganic forms. Molecular mechanisms implicated in arsenic hepatotoxicity are complex but include oxidative stress, apoptosis, and autophagy. The current study focused on the potential protective capacity of melatonin against arsenic-induced hepatotoxicity. Thirty-six male Wistar rats were allocated into control, arsenic
-
Netrin-1 protects blood–brain barrier (BBB) integrity after cerebral ischemia-reperfusion by activating the Kruppel-like factor 2 (KLF2)/occludin pathway J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-02 Yuanxiao Li, Changyun Liu, Zhiting Chen, Hanbin Lin, Xiaofeng Li
-
Synthesis, biological evaluation, and In silico molecular docking of N-(4-(4-substitutedphenyl)-6-(substituted aryl) pyrimidin-2-yl)-2-(2-isonicotinoyl hydrazinyl) acetamide J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-04 Hetal I. Soni, Navin B. Patel, Iqrar Ahmad, Harun Patel, Gildardo Rivera
-
Dexpanthenol exhibits antiapoptotic and anti-inflammatory effects against nicotine-induced liver damage by modulating Bax/Bcl-xL, Caspase-3/9, and Akt/NF-κB pathways J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-02 Nuray Üremiş, Meral Aslan, Elif Taşlidere, Elif Gürel
-
High mobility group box 1 knockdown inhibits EV71 replication and attenuates cell pyroptosis through TLR4/NF-κB/NLRP3 axis J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2024-01-03 Yufeng Zhang, Jing Li, Huiling Deng, Han Wan, Pengfei Xu, Jun Wang, Ruiqing Liu, Tiantian Tang
-
C/EBPα alleviates hepatic ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress via HDAC1-mediated deacetylation of ATF4 J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-29 Rong Li, Longbao Yang, Shunle Li, Shuo Chen, Yifan Ren, Lin Shen, Lei Dong, Xi Chen, Junhui Li, Meng Xu
-
miRNA-211-5p inhibition enhances the protective effect of hucMSC-derived exosome in Aβ1-40-induced SH-SY5Y cells by increasing NEP expression J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-30 Huijing Chen, Zhongqin Huang, Aidi Lei, Xiaowen Yu, MeiLing Shen, Dan Wu
Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) could alleviate Alzheimer's disease (AD) defects. Additionally, engineered exosomes are more effective in treating diseases. In this study, we established an in vitro model of AD by treating SH-SY5Y cells with Aβ1-40. We observed that incubation with hucMSC-derived exosomes effectively protected SH-S5Y5 cells from Aβ1-40-induced
-
Andrographolide protect against lipopolysacharides induced vascular endothelium dysfunction by abrogation of oxidative stress and chronic inflammation in Sprague–Dawley rats J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-30 Debiprasad Padhy, Satyam Sharma, Sanjiv Singh
The development of heart disease involves interconnected factors such as oxidative stress, inflammation, and vascular dysfunction. Andrographolide (AG), known for its potent antioxidant and anti-inflammatory properties, has the potential to counteract lipopolysaccharides (LPS)-induced endothelial dysfunction by reducing oxidative stress and inflammation. Our research aimed to investigate the effects
-
Oxymatrine impedes the progression of endotoxin-induced glaucoma via redox system modulations J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-29 Ashmita Das, Onkar Kashyap, Devi P. Pandey, Surendra H. Bodakhe
This study aimed to provide irrefutable evidence of the preventive effects of oxymatine (OMT) on a model of endotoxin induced glaucoma in Wistar rats which can be attributed to its anti-inflammatory, antioxidant, and TNF-α antagonistic properties. To assess the impact of OMT on uveitic glaucoma, the normal group received 100 μL distilled water topically for 15 days, while the glaucoma control group
-
Mechanism of non-small cell lung cancer cell-derived exosome miR-196b-5p promoting pyroptosis of tumor T cells and tumor cell proliferation by downregulating ING5 J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-27 Zhixian Zhang, Lei Yang, Xuefen Lei, Jia Yu, Lijuan Wang, Hongming Cao, Hou Gu
-
The progression of obstructive renal fibrosis in rats is regulated by ADAMTS18 gene methylation in the embryonic kidney through the AKT/Notch pathway J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-26 Ben Xu, Jia-en Zhang, Lin Ye, Chang-wei Yuan
This study aimed to explore the mechanism by which postembryonic renal ADAMTS18 methylation influences obstructive renal fibrosis in rats. After exposure to transforming growth factor (TGF)-β1 during the embryonic period, analysis of postembryonic renal ADAMTS18 methylation and expression levels was conducted. Histological analysis was performed to assess embryonic kidney lesions and damage. Western
-
PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-26 Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpour
-
Beneficial effect of 5-HT1b/1d agonist on Parkinson's disease by modulating glutamate and reducing deposition of α-synuclein J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-26 Alok Shiomurti Tripathi, Needa Fatima, Pankaj Tripathi, Rina Tripathi, Alka, Magdi E. A. Zaki, Lucy Mohapatra, Mohammad Yasir, Rahul K Maurya
The given investigation examined the neuroprotection role of 5-HT1b/1d agonist in reserpine induced Parkinson's disease (PD) in male Wistar rats. PD was induced in rats by reserpine at 5 mg/kg ip for 3 days and thereafter the rats were provided with the following treatments for 4 days, zolmitriptan (ZLM) group (30 mg/kg ip); STD group (levodopa + carbidopa, 200 + 5 mg/kg ip); ZLM + GA group (zolmitriptan
-
METTL14-mediated lncRNA XIST silencing alleviates GDM progression by facilitating trophoblast cell proliferation and migration via the miR-497-5p/FOXO1 axis J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-26 Yanchuan Li, Yanfeng Liu, Xiao Yao, Haili Wang, Ziyun Shi, Meiqing He
Gestational diabetes mellitus (GDM), a prevalent complication during the gestation period, has been linked to impaired proliferation and migration of trophoblasts causing placental maldevelopment. We previously found that lncRNA X-inactive specific transcript (XIST) played an essential role in GDM progression. Here, we investigated the precise biological functions as well as the upstream and downstream
-
Lixisenatide ameliorated lipopolysaccharide (LPS)-induced expression of mucin and inflammation in bronchial epithelial cells J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-21 Leiming Xu, Guoping Chen, Leiming Zhang, Aifeng He, Yong Li
Chronic obstructive pulmonary disease (COPD) induces serious social and economic burdens due to its high disability and mortality, the pathogenesis of which is highly involved with inflammation, oxidative stress (OS), and mechanism of mucin 5AC (MUC5AC) secretion. Lixisenatide is a selective glucagon-like peptide 1 receptor agonist recently reported to have anti-inflammatory properties. Our study will
-
MiR-600 mediates EZH2/RUNX3 signal axis to modulate breast cancer cell viability and sorafenib sensitivity J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-21 Qian Zhao, Dan Li, Jinchun Feng, Dilixiati Jinsihan
Breast cancer (BC) ranks as the most prevalent gynecologic tumor globally. Abnormal expression of miRNAs is concerned with the development of cancers such as BC. However, little is known about the role of miR-600 in BC. This work aimed to explore the role of miR-600 in the malignant progression and sorafenib sensitivity of BC cells. Expression and interaction of miR-600/EZH2/RUNX3 were analyzed by
-
Association of air pollution and risk of chronic kidney disease: A systematic review and meta-analysis J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-13 Wenqi Xu, Luzhu Jia, Yuxuan Lin, Cong Zhang, Xiance Sun, Liping Jiang, Xiaofeng Yao, Ningning Wang, Haoyuan Deng, Shaopeng Wang, Guang Yang
-
Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-13 Ahsas Goyal, Kunal Solanki, Aanchal Verma
-
HAGLR, stabilized by m6A modification, triggers PTEN-Akt signaling cascade-mediated RPE cell pyroptosis via sponging miR-106b-5p J. Biochem. Mol. Toxicol. (IF 3.6) Pub Date : 2023-12-13 Rong Luo, Lan Li, Qingluan Han, Jingsong Fu, Fan Xiao
Consistent hyperglycaemia on retinal microvascular tissues is recognized as a vital inducer of diabetic retinopathy (DR) pathogenesis. In view of the essential functionality of long noncoding RNAs (lncRNAs) in multiple human diseases, we aim to figure out the exact role and underlying mechanisms of lncRNA HOXD Cluster Antisense RNA 1 (HAGLR) in DR pathogenesis. Serum specimens from patients with proliferative