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κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-28 Yi Shi,Huaqiang Tao,Xueyan Li,Liyuan Zhang,Chunhui Li,Wen Sun,Miao Chu,Kai Chen,Pengfei Zhu,Qiang Wang,Chengyong Gu,Liangliang Wang,Xing Yang,Yuefeng Hao
Osteoarthritis (OA) is a prevalent and chronic joint disease that affects the aging population, causing pain and disability. Macrophages in synovium are important mediators of synovial inflammatory activity and pathological joint pain. Previous studies have demonstrated the significant involvement of κ-opioid receptor (KOR) in the regulation of pain and inflammation. Our study reveals a significant
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Dexmedetomidine ameliorates high glucose-induced epithelial-mesenchymal transformation in HK-2 cells through the Cdk5/Drp1/ROS pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-27 Fei Wang,Weilong Xu,Xiaoge Liu,Jun Zhang
Epithelial-mesenchymal transformation (EMT) plays an important role in the progression of diabetic nephropathy. Dexmedetomidine (DEX) has shown renoprotective effects against ischemic reperfusion injury; however, whether and how DEX prevents high glucose-induced EMT in renal tubular epithelial cells is incompletely known. Here, we conduct in vitro experiments using HK-2 cells, a human tubular epithelial
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Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-27 Shuhan Jin,Bo Li,Bibo Zhang,Xuejie Gao,Xinyan Jia,Li Xu,Shuaikang Chang,Ke Hu,Guanli Wang,Zhijian Xu,Ting Zhang,Dongliang Song,Guang Yang,Xiaosong Wu,Huabin Zhu,Cheng Huang,Yumeng Lu,Jumei Shi,Weiliang Zhu,Gege Chen
Multiple myeloma (MM) is characterized by excessive aggregation of B-cell-derived malignant plasma cells in the hematopoietic system of bone marrow. Previously, we synthesized an innovative molecule named dihydrocelastrol (DHCE) from celastrol, a triterpene purified from medicinal plant Tripterygium wilfordii. Herein, we explore the therapeutic properties and latent signal transduction mechanism of
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HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-24 Fang Ma,Honglin Liu,Tongtong Xia,Zhenghao Zhang,Shengchao Ma,Yinju Hao,Jiangyong Shen,Yideng Jiang,Nan Li
Hypertrophic scar (HS) is one of the most common sequelae of patients, especially after burns and trauma. The roles of regulatory long noncoding RNAs (lncRNAs) in mediating HS remain underexplored. Human hypertrophic scar-derived fibroblasts (HSFBs) have been shown to exert more potent promoting effects on extracellular matrix (ECM) accumulation than normal skin-derived fibroblasts (NSFBs) and are
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Restraint stress promotes nonalcoholic steatohepatitis by regulating the farnesoid X receptor/NLRP3 signaling pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-24 Fan Yang,Xi-Ting Lv,Xiao-Li Lin,Ruo-Hong Wang,Shu-Mei Wang,Guo-En Wang
Psychological stress promotes nonalcoholic steatohepatitis (NASH) development. However, the pathogenesis of psychological stress-induced NASH remains unclear. This study aims to explore the underlying mechanism of restraint stress-induced NASH, which mimics psychological stress, and to discover potential NASH candidates. Methionine choline deficient diet- and high fat diet-induced hepatosteatotic mice
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lncRNA ENST00000422059 promotes cell proliferation and inhibits cell apoptosis in breast cancer by regulating the miR-145-5p/KLF5 axis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-23 Yiping Zhu,Junling Ren,Xu Wu,Yuan Zhang,Ying Wang,Jinwen Xu,Qiuyu Tan,Yuxin Jiang,Yulei Li
Krüppel-like zinc-finger transcription factor 5 (KLF5) is a vital regulator of breast cancer (BC) onset and progression. The mechanism by which KLF5 regulates BC is still not clearly known. In this study, bioinformatics analysis shows that BC-affected individuals with elevated KLF5 expression levels have poor clinical outcomes. We further verify that miR-145-5p regulated KLF5 expression to promote
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Y-box protein-1 modulates circSPECC1 to promote glioma tumorigenesis via miR-615-5p/HIP1/AKT axis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-23 Ping Lan,Meihe Li,Ying Wang,Jingwen Wang,Luyao Li,Sha Zhang,Xuan Zhang,Caihong Ran,Jin Zheng,Huilin Gong
Y-box binding protein-1 (YB-1) is upregulated in glioma and plays an important role in its occurrence and drug resistance. However, the involved regulatory processes and downstream pathways are still unclear. Since various circular RNAs (circRNAs) and microRNAs (miRNAs) also play roles in the pathogenesis of glioma, we hypothesize that YB-1 may exert its function through a circRNA-miRNA-protein interaction
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Selective inhibition of the NLRP3 inflammasome protects against acute ethanol-induced cardiotoxicity in an FBXL2-dependent manner. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-22 Meng Yuan,Asli F Ceylan,Rifeng Gao,Hong Zhu,Yingmei Zhang,Jun Ren
Binge drinking exerts cardiac toxicity through various mechanisms, including oxidative stress and inflammation. NLRP3 inflammasomes possess both pro- and anti-inflammatory properties, although the role of NLRP3 in ethanol-induced cardiotoxicity remains unknown. This study is designed to examine the role of NLRP3 inflammasome in acute ethanol cardiotoxicity and the underlying mechanisms of action. Nine-
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Selenium enhances photodynamic therapy of C-phycocyanin against lung cancer via dual regulation of cytotoxicity and antioxidant activity. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-22 Jie Shen,Haidong Xia,Xiaojing Zhou,Lei Zhang,Qian Gao,Kan He,Dahai Liu,Bei Huang
As a natural photosensitizer, phycocyanin (PC) has high efficiency and uses low-intensity irradiation. To enhance the photodynamic therapy (PDT) of PC, we extract selenium-enriched phycocyanin (Se-PC) from Se-enriched Spirulina platensis and examine the synergistic effect of PC combined with selenium against lung tumors. In vitro experiments reveal that Se-PC PDT more efficiently reduce the survival
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Deciphering GABBR1-centered drug targets to fight viral infection with preexisting diabetes. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-15 Xiangqi Li,Xuemei Zhao,Li Peng,Hong Du,Shiwei Chen,Xia Chen
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Evolution of GCGR family ligand‒receptor extensive cross-interaction systems suggests a therapeutic direction for hyperglycemia in mammals. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-15 Jian Liu,Xue Wang,WenLi Zhang,Guangneng Liao,Zhenhua Shao,Juergen Brosius,Cheng Deng,Shanshan Lai,Enwu Long
Glucose is essential to the physiological processes of vertebrates. Mammalian physiological stability requires a relatively stable blood glucose level (~5 mmol/L), whereas other vertebrates have greater flexibility in regulating blood glucose (0.5-25 mmol/L). GCGR family receptors play an important role in vertebrate glucose regulation. Here, we examine the evolution of the GCGR family ligand‒receptor
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Mesenchymal stem cell exosomes inhibit nucleus pulposus cell apoptosis via the miR-125b-5p/TRAF6/NF-κB pathway axis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-15 Yang Duan,Cheng Yu,Wenhao Kuang,Jianjun Li,Sujun Qiu,Songjia Ni,Zhong Chen
Intervertebral disc degeneration (IVDD) is the pathological basis of a range of degenerative spinal diseases and is the primary cause of lower back pain. Mesenchymal stem cell (MSC) transplantation inhibits IVDD progression. However, the specific mechanisms that underlie these effects remain unclear. In this study, candidate microRNAs (miRNAs) are screened using bioinformatics and high-throughput sequencing
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Clock gene Per3 deficiency disrupts circadian alterations of gut microbiota in mice. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-11-15 Xiaoxian Xie,Haoshen Xu,Ruonan Shu,Lei Sun,Mengya Zhang,Qinglian Hu,Kai Zhu,Zezhi Li,Fengchun Wu
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RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-30 Chi Liu,Jie Shi,Zhengyuan Jiang,Shan Jiang,Yuan Wu,Dongqian Peng,Jiebing Tang,Linchi Guo
The incidence and related death of hepatocellular carcinoma (HCC) have increased over the past decades. However, the molecular mechanisms underlying HCC pathogenesis are not fully understood. Long noncoding RNA (lncRNA) RP11-495P10.1 has been proven to be closely associated with the progression of prostate cancer, but its role and specific mechanism in HCC are still unknown. Here, we identify that
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Tumor-associated microbiota in colorectal cancer with vascular tumor thrombus and neural invasion and association with clinical prognosis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-30 Mingjie Li,Min Jin,Lei Zhao,Dandan Yu,Yan Li,Linli Shi,Bin Zhou,Li Liu,Yinghao Cao,Kailin Cai,Jun Fan,Xiu Nie,Tao Zhang,Hongli Liu
Neural invasion (NI) and vascular tumor thrombus (VT) are associated with poor prognosis in patients with colorectal cancer (CRC). In this study, we apply 16S rRNA amplicon sequencing to tumor tissues and adjacent normal tissues in patients with CRC to determine the microbial differences. A discovery cohort, including 30 patients with NI, 23 with VT, and 35 with double-negative CRC tissue, is utilized
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Evaluation of the protective effect of salidroside on arsenic-induced cardiac dysfunction in rats. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-30 Ruimeng Tian,Jing Cheng,Yanna Wang,Chuncui Chen,Lei Huang,Caiyun Zhang,Yifei Zhou,Shanshan Dong,Guilin Lu,Wenjuan Qin
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Cryptococcus gattii strains with a high phagocytosis phenotype by macrophages display high pathogenicity at the early stage of infection in vivo. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-26 Chen Yang,Wanjun Shen,Lifeng Wang,Xuelei Zang,Yemei Huang,Hengyu Deng,Yangyu Zhou,Mei Xie,Xinying Xue,Dingxia Shen
Cryptococcus gattii (Cg) is a facultative intracellular pathogen that can replicate and disseminate in mammalian macrophages, causing life-threatening cryptococcosis in both immunocompetent and immunocompromised individuals. Cryptococcus-macrophage interactions are crucial for cryptococcosis prognosis. However, the relationship between Cg pathogenicity and phagocytosis by macrophages has not yet been
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The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-23 Qianqian Yang,Hui Tian,Ziyi Guo,Zhongliang Ma,Guangzhi Wang
Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells. Hypoxia is an important component of the TME, and hypoxia-inducible factor-1α (HIF-1α) is the most important transcriptional regulator. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs
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NF-κB downstream miR-1262 disturbs colon cancer cell malignant behaviors by targeting FGFR1. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-20 Weilin Zhang,Zhongcheng Huang,Zhigang Xiao,Hui Wang,Qianchao Liao,Zhengru Deng,Deqing Wu,Junjiang Wang,Yong Li
Despite substantial advancements in screening, surgery, and chemotherapy, colorectal cancer remains the second most lethal form of the disease. Nuclear factor kappa B (NF-κB) signaling is a critical driver facilitating the malignant transformation of chronic inflammatory bowel diseases. In this study, deregulated miRNAs that could play a role in colon cancer are analyzed and investigated for specific
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TXNIP aggravates cardiac fibrosis and dysfunction after myocardial infarction in mice by enhancing the TGFB1/Smad3 pathway and promoting NLRP3 inflammasome activation. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-17 Yan Zhang,Jin Wang,Xuejiao Wang,Aiyun Li,Zhandong Lei,Dongxue Li,Dehai Xing,Yichao Zhang,Wanzhen Su,Xiangying Jiao
Myocardial infarction (MI) results in high mortality. The size of fibrotic scar tissue following MI is an independent predictor of MI outcomes. Thioredoxin-interacting protein (TXNIP) is involved in various fibrotic diseases. Its role in post-MI cardiac fibrosis, however, remains poorly understood. In the present study, we investigate the biological role of TXNIP in post-MI cardiac fibrosis and the
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Preliminary exploration of SKA1 expression in lung adenocarcinoma and its clinical significance. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-09 Wen Zeng,Yong Chen,Jun Liu,Zhen An,Hui Yan,Tao Sun
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Single-cell dissection, hdWGCNA and deep learning reveal the role of oxidatively stressed plasma cells in ulcerative colitis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-09 Shaocong Mo,Xin Shen,Baoxiang Huang,Yulin Wang,Lingxi Lin,Qiuming Chen,Meilin Weng,Takehito Sugasawa,Wenchao Gu,Yoshito Tsushima,Takahito Nakajima
Ulcerative colitis (UC) develops as a result of complex interactions between various cell types in the mucosal microenvironment. In this study, we aim to elucidate the pathogenesis of ulcerative colitis at the single-cell level and unveil its clinical significance. Using single-cell RNA sequencing and high-dimensional weighted gene co-expression network analysis, we identify a subpopulation of plasma
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Alternating current stimulation promotes neurite outgrowth and plasticity in neurons through activation of the PI3K/AKT signaling pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-09 Hao Zhong,Cong Xing,Mi Zhou,Zeyu Jia,Song Liu,Shibo Zhu,Bo Li,Hongjiang Yang,Hongpeng Ma,Liyue Wang,Rusen Zhu,Zhigang Qu,Guangzhi Ning
As a commonly used physical intervention, electrical stimulation (ES) has been demonstrated to be effective in the treatment of central nervous system disorders. Currently, researchers are studying the effects of electrical stimulation on individual neurons and neural networks, which are dependent on factors such as stimulation intensity, duration, location, and neuronal properties. However, the exact
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PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-09 Yuyao Li,Tanglong Yuan,Hongwei Zhang,Shuting Liu,Jie Lun,Jing Guo,Yu Wang,Yuying Zhang,Jing Fang
Prolyl hydroxylase 3 (PHD3) hydroxylates HIFα in the presence of oxygen, leading to HIFα degradation. PHD3 inhibits tumorigenesis. However, the underlying mechanism is not well understood. Herein, we demonstrate that PHD3 inhibits the metastasis of colon cancer cells through the occludin-p38 MAPK pathway independent of its hydroxylase activity. We find that PHD3 inhibits colon cancer cell metastasis
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A novel ferroptosis-related microRNA signature with prognostic value in osteosarcoma. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-10-08 Jie Shao,Yi Zhang,Zhu Chang,Shiyao Du,Wei Li,Yushu Bai,Chunwen Lu,Tianming Xu
The induction of ferroptosis is suggested to be a potential therapeutic strategy for cancers. MicroRNAs (miRNAs) are reported to play an important role in cell death processes. This study aims to construct and validate a risk model based on ferroptosis-related miRNAs (FR_miRNAs) to predict prognosis and identify novel therapeutic targets for osteosarcoma. Data from the Therapeutically Applicable Research
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Down-regulation of miR-486-5p expression inhibits the proliferation and invasion of human extravillous trophoblasts, and decreased peripheral plasma miR-486-5p level is associated with human early pregnancy loss. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-28 Yan Gu,Ning Song,Wen-Wen Gu,Linghan Chen,Xuan Zhang,Jian Wang
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Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-28 Shasha Hu,Yueting Kou,Xiaochen Liu,Weifang Rong,Hongxiu Han,Guohua Zhang
Hyperglycemia drives dysfunction of the intestinal barrier. 5-Hydroxytryptaine 4 receptor (5-HT 4R) agonists have been considered therapeutics for constipation in clnic. However, the roles of 5-HT 4R activation in mucosa should be fully realized. Here, we investigate the effects of 5-HT 4R activation on diabetes-induced disruption of the tight junction (TJ) barrier in the colon. Not surprisingly, the
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LincRNA-P21 knockdown facilitates esophageal squamous cell carcinoma cell progression by upregulating cadherin 5 via YTH domain containing 1. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-27 Jianjun Wang,Li Zhu,Quan Zhang,Tian Xia,Wenjian Yao,Li Wei
LincRNA-P21 is a tumor suppressor in esophageal squamous cell carcinoma (ESCC). Cell adhesion modules play vital roles in cell-cell and cell-extracellular matrix (ECM) interactions and malignant cancer progression. In this study, we investigate whether lincRNA-P21 exerts its functions by regulating the cell adhesion molecule cadherin 5 (CDH5) in ESCC. Moreover, the RNA binding protein (RBP) mediators
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Progress in patient-derived liver cancer cell models: a step forward for precision medicine. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-27 Zhengtao Zhang,Lijian Hui
The development of effective precision treatments for liver cancers has been hindered by the scarcity of preclinical models that accurately reflect the heterogeneity of this disease. Recent progress in developing patient-derived liver cancer cell lines and organoids has paved the way for precision medicine research. These expandable resources of liver cancer cell models enable a full spectrum of pharmacogenomic
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LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-18 Shuoyan Xu,Zhiming Cheng,Bulin Du,Yao Diao,Yaming Li,Xuena Li
AP000695.2 is a novel long non-coding RNA (lncRNA). Its aberrant high expression is remarkably associated with poor prognosis of patients with lung adenocarcinoma (LUAD). However, its role and underlying mechanism in LUAD remains unclear. Previous bioinformatics analysis indicated that AP000695.2 may be closely related to the glycolysis of LUAD. This study aims to verify and explore the mechanism of
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Jinfukang inhibits clustering and invasion of circulating lung tumor cells by regulating the EGFR signaling pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-18 Yun Yang,Lihua Zhu,Jiajun Liu,Pan Yu,Zujun Que,Yan Li,Hegen Li,Jianhui Tian
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CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-15 Di Wu,Jiahui Zhu,Fang Yang,Riwang Li,Lexin Liu,Dahai Liu,Chi Liu,Xiangping Qu,Huijun Liu,Ming Ji,Xiaoqun Qin,Lan Hua,Yang Xiang
The downregulation of adhesion molecule catenin alpha-like 1 (CTNNAL1) in airway epithelial cells of asthma patients and house dust mite (HDM)-induced asthma animal models was illustrated in our previous study. It is assumed to contribute to airway inflammation and mucus hypersecretion. In this work, we further explore the underlying mechanism of CTNNAL1 in asthma. CTNNAL1-silenced female mice exhibit
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Long noncoding RNA KCNMB2-AS1 acts as an oncogene in ovarian cancer. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-14 Siyu Cao,Min Liu,Ziyi Guo,Yanli Li
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Metabolic signatures and potential biomarkers for the diagnosis and treatment of colon cancer cachexia. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-14 Xu Qiu,Ruohan Lu,Qiqing He,Shu Chen,Caihua Huang,Donghai Lin
Cancer cachexia (CAC) is a debilitating condition that often arises from noncachexia cancer (NCAC), with distinct metabolic characteristics and medical treatments. However, the metabolic changes and underlying molecular mechanisms during cachexia progression remain poorly understood. Understanding the progression of CAC is crucial for developing diagnostic approaches to distinguish between CAC and
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Crystal structure of the GDSL family esterase EstL5 in complex with PMSF reveals a branch channel of the active site pocket. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-14 Runsha Chen,Xuechun Gao,Ting Nie,Jinhong Wu,Lin Wang,Ali Osman,Yan Feng,Xianghong Li,Yong Zhang
Esterases/lipases from the GDSL family have potential applications in the hydrolysis and synthesis of important esters of pharmaceutical, food, and biotechnical interests. However, the structural and functional understanding of GDSL enzymes is still limited. Here, we report the crystal structure of the GDSL family esterase EstL5 complexed with PMSF at 2.34 Å resolution. Intriguingly, the PMSF binding
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Transcriptomic and genomic identification of spliceosomal genes from Euglena gracilis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-13 Pingwei Gao,Yujie Zhong,Chengfu Sun
Diverse splicing types in nuclear and chloroplast genes of protist Euglena gracilis have been recognized for decades. However, the splicing machinery responsible for processing nuclear precursor messenger RNA introns, including trans-splicing of the 5' terminal outron and spliced leader (SL) RNA, remains elusive. Here, we identify 166 spliceosomal protein genes and two snRNA genes from E. gracilis
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S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-12 Xinyan Zhu,Zihui Tang,Wei Li,Xiaojuan Li,Yasuko Iwakiri,Fei Liu
The mechanism of extracellular matrix metalloproteinase inducer (EMMPRIN) in the regulation of liver fibrosis has not been clarified. This study aims to investigate the role of EMMPRIN S-nitrosylation (SNO) in the regulation of hepatic stellate cell (HSC) migration and matrix metalloproteinase (MMP) activities in liver fibrosis. The results from the tissue microarrays and rat/mouse liver tissues suggest
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FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-11 Liyang Yin,Renxian Cao,Zhuoqing Liu,Gang Luo,Yu Li,Xiaolong Zhou,Xiguang Chen,Ying Wu,Jun He,Xuyu Zu,Yingying Shen
Triple-negative breast cancer (TNBC) lacks effective therapeutic targets and has a poor prognosis, easy recurrence and metastasis. It is urgent and important to explore TNBC treatment targets. Through mass spectrometry combined with qRT-PCR validation in luminal A cells and TNBC cells, high-content screening and clinical sample analysis, FUNDC2 was discovered as a novel target. The function of the
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ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-07 Aiping Xu,Mingchuang Sun,Zhaoxing Li,Yuan Chu,Kang Fang,Yunwei Zhang,Jingjing Lian,Li Zhang,Tao Chen,Meidong Xu
Esophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in ESCC and adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) is the main upregulated transcription
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GLUT5: structure, functions, diseases and potential applications. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-07 Aqian Song,Yuanpeng Mao,Hongshan Wei
Glucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has
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A novel homozygous splice variant in DNAAF4 is associated with asthenozoospermia. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-07 Xiaobin Zhu,Chen Chen,Jian Song,Shijue Dong,Xuhui Zeng,Zhihong Niu,Yanwei Sha,Xiaoning Zhang
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Fucosyltransferase 9 promotes neuronal differentiation and functional recovery after spinal cord injury by suppressing the activation of Notch signaling. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-06 Jiewen Chen,Xiaolin Zeng,Wenwu Zhang,Gang Li,Haoming Zhong,Chengzhong Xu,Xiang Li,Tao Lin
Individuals with spinal cord injury (SCI) suffer from permanent disabilities such as severe motor, sensory and autonomic dysfunction. Neural stem cell transplantation has proven to be a potential strategy to promote regeneration of the spinal cord, since NSCs can produce neurotrophic growth factors and differentiate into mature neurons to reconstruct the injured site. However, it is necessary to optimize
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Crosstalk between lung cancer cells and macrophages contributes to traditional Chinese medicine Feiyanning-induced anti-tumor activities by suppressing M2 macrophage polarization. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-04 Kaiqing Zhang,Yonglin Peng,Qingting Wang,Sheng Tan,Bin Wang,Huaqin Tian,Xiaodong Zhao,Ming Zhang
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Suitable carrier protein and linker peptide significantly increase the secretory expression of human lysozyme in Aspergillus niger. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-09-04 Qi Wu,Can Xu,Wei Shi,Lifang Li,Hui Zhang,Tianqi Liu,Junbo Fan,Lingmeng Cui,Jie Li
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Methyl cinnamate protects against dextran sulfate sodium-induced colitis in mice by inhibiting the MAPK signaling pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-31 Lilin E,Wenjie Li,Yuanjia Hu,Lijuan Deng,Jianping Yao,Xingwang Zhou
Effective and non-toxic therapeutic agents are lacking for the prevention and treatment of colitis. Previous studies found that methyl cinnamate (MC), extracted from galangal ( Alpinia officinarum Hance), has anti-inflammatory properties. However, whether MC is effective as anti-colitis therapy remains unknown. In this study, we investigate the therapeutic effects of MC on dextran sulfate sodium (DSS)-induced
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Discovery of age-related early-stage glycated proteins based on deep quantitative serum glycated proteome analysis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-31 Xinyue Ren,Linlin Wu,Lei Zhang,Yang Liu,Guoli Wang,Haojie Lu
Aging is a pressing global health issue that is linked to various diseases, such as diabetes and Alzheimer's disease. It is well known that glycation plays a pathological role in the aging process and age-related diseases. Thus, it is of great significance to discover protein glycation at an early stage for monitoring and intervention in the aging process. However, the endogenous age-related early-stage
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HDAC6 inhibition regulates substrate stiffness-mediated inflammation signaling in chondrocytes. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-29 Yang Zhang,Godfred K Tawiah,Yanjun Zhang,Xiaohu Wang,Xiaochun Wei,Weiyi Chen,Xiaohong Qiao,Quanyou Zhang
Osteoarthritis (OA) is a chronic disease and is difficult to cure. Chondrocytes are highly mechanosensitive. Therefore, mechanical therapies have received attention as a therapeutic direction for OA. The stiffness, as a critical cue of the extracellular matrix (ECM), affects cell growth, development, and death. In this study, we use polydimethylsiloxane (PDMS) to create substrates with varying stiffness
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WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-28 Qiujie Gao,Gang Liu,Lihua Huang,Yunfei Zhang,Xinxing Zhang,Xiaoyue Song,Xiaowei Xing
The WD40-repeat containing (WDR) proteins are enriched in the testis and play important roles in spermatogenesis. In the present study, we investigate the expression profile of WDR38, a novel member of the WDR protein family, in humans and mice. RT-qPCR (reverse transcription-quantitative polymerase chain reaction) results demonstrate that WDR38 mRNA is abundantly expressed in both the human and mouse
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Immunol detection of cathepsin L from Fasciola hepatica infection in sheep by monoclonal antibody-based colloidal gold test strip assay. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-28 Shaoxiong Liu,Nan Zhang,Qinlei Yu,Jianhua Li,Xiaocen Wang,Xin Li,Xu Zhang,Shuqin Cheng,Taotao Yue,Hongbo Zhang,Pengtao Gong,Xichen Zhang
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MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-17 Hao Zhang,Si Shen,Chong Feng,Gang Chen,Xinxing Wang
Microfibrillar-associated protein 2 (MFAP2) is a small glycoprotein that is involved in vascular development and metabolic disease. The present study aims to explore the regulatory role of MFAP2 in the development and progression of oral squamous cell carcinoma (OSCC), including the underlying mechanisms. MFAP2 expression and its association with the progression of OSCC are explored using bioinformatics
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Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-16 Danyang Tian,Jinqi Meng,Lin Li,Hongmei Xue,Qi Geng,Yuxin Miao,Meng Xu,Ru Wang,Xiangjian Zhang,Yuming Wu
Mounting evidence demonstrates that hydrogen sulfide (H 2S) promotes anti-inflammatory molecules and inhibits pro-inflammatory cytokines in endothelial cells (ECs). This study aims to investigate the favorable action of H 2S on endothelial function in senescence by inhibiting the production of inflammatory molecules. Senescent ECs exhibit a reduction in H 2S, endothelial nitric oxide synthase (eNOS)
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Ubiquitination in the regulation of autophagy. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-16 Xueyan Cen,Ziling Li,Xinpeng Chen
Autophagy, an efficient and effective approach to clear rapidly damaged organelles, macromolecules, and other harmful cellular components, enables the recycling of nutrient materials and supply of nutrients to maintain cellular homeostasis. Ubiquitination plays an important regulatory role in autophagy. This paper summarizes the most recent progress in ubiquitin modification in various stages of autophagy
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PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-15 Gongyu Fu,Shi-Ting Li,Zetan Jiang,Qiankun Mao,Nanchi Xiong,Xiang Li,Yijie Hao,Huafeng Zhang
Tumor metabolic reprogramming and epigenetic modification work together to promote tumorigenesis and development. Protein lysine acetylation, which affects a variety of biological functions of proteins, plays an important role under physiological and pathological conditions. Here, through immunoprecipitation and mass spectrum data, we show that phosphoglycerate mutase 5 (PGAM5) deacetylation enhances
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ZNF205 positively regulates RLR antiviral signaling by targeting RIG-I. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-14 Ni Zhong,Chen Wang,Guangxiu Weng,Ting Ling,Liangguo Xu
Retinoic acid-inducible gene I (RIG-I) is a cytosolic viral RNA receptor. Upon viral infection, the protein recognizes and then recruits adapter protein mitochondrial antiviral signaling (MAVS) protein, initiating the production of interferons and proinflammatory cytokines to establish an antiviral state. In the present study, we identify zinc finger protein 205 (ZNF205) which associates with RIG-I
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Developing drugs targeting CX3CL1 to treat heart diseases via immune/inflammatory mediation. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-14 Lin Zou,Junhua Ma,Guiying Hu,Hongling Zhu,Lijuan Zhang,Xiangqi Li
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RBM14 promotes DNA end resection during homologous recombination repair. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-10 Zheng Li,Yanting Liao,Chen Tang,Linli Xu,Bin Peng,Xingzhi Xu
DNA double-strand break (DSB) repair by homologous recombination (HR) is crucial for the maintenance of genome stability and integrity. In this study, we aim to identify novel RNA binding proteins (RBPs) involved in HR repair because little is known about RBP function in HR. For this purpose, we carry out pulldown assays using a synthetic ssDNA/dsDNA structure coated with replication protein A (RPA)
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Synergistic antitumor effects of circularly permuted TRAIL with doxorubicin in triple-negative breast cancer. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-10 Jia Liu,Tienian Zhu,Jiankun Liu,Yujie Cui,Shifang Yang,Ruijing Zhao
Circularly permuted TRAIL (CPT), a novel recombinant TRAIL mutant, is a potent antitumor agent. However, its efficacy in triple-negative breast cancer (TNBC) remains unclear. Treatment with CPT alone and in combination with doxorubicin (Dox) is explored for its effects on the proliferation and apoptosis of MDA-MB-231 (MB231) and MDA-MB-436 (MB436) breast cancer cells in vitro and in vivo. Here, we
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HHV-6B infection after umbilical cord blood stem cell transplantation with pruritus as the first symptom. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-09 Bin Xu,Yan Jia,Linlin Lv,Lulu Chen,Panpan Cheng,Saisai Ren,Haihui Liu,Min Zhang,Hao Zhang
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Mesoscale sequence feature modulates AID activity in antibody diversification. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-03 Jiayang Li,Hai-Qiang Dai
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Transaldolase inhibits CD36 expression by modulating glutathione-p38 signaling, exerting protective effects against macrophage foam cell formation. Acta Biochim. Biophys. Sin. (IF 3.7) Pub Date : 2023-08-01 Chengyi Li,Zihao Song,Pengyue Gao,Wei Duan,Xiu Liu,Sijia Liang,Quan Gong,Jiawei Guo
In atherosclerosis, macrophage-derived foam cell formation is considered to be a hallmark of the pathological process; this occurs via the uptake of modified lipoproteins. In the present study, we aim to determine the role of transaldolase in foam cell formation and atherogenesis and reveal the mechanisms underlying its role. Bone marrow-derived macrophages (BMDMs) isolated from mice successfully form