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Synthesis, Characterization of Formazan Derivatives from Isoniazid and Study Their Antioxidant Activity and Molecular Docking Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 W. K. Damdoom, O. H. R. Al-Jeilawi
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Synthesis and Biological Evaluation of Coumarin-Amino Acid-Benzotriazole Conjugates Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 Emre Menteşe, Nedime Çalışkan, Bahar Bilgin Sökmen, Gülay Akyüz
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New Coumarin-Metronidazole Composites: Synthesis, Biocompatibility, and Anti-anaerobic Bacterial Activity Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 Yasser Fakri Mustafa
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Benzothiophene Schiff Bases Disrupt Cytoplasmic Membrane Integrity of Gram-Positive and -Negative Bacteria Cells Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 Bengü Ergüden, Hatice Büşra Lüleci, Yasemin Ünver
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2,5-Dimethoxy-Benzylidene-Rhodanine and Its Acyclic Analogues as Selective Fluorogenic Dyes for Lipid Droplets of Living Cells Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 S. A. Krasnova, Yu. A. Bogdanova, A. I. Sokolov, I. N. Myasnyanko, A. Yu. Smirnov, M. S. Baranov
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Pyrazinamide Analogs Designed for Rational Drug Designing Strategies Against Resistant Tuberculosis (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 Xinyu Wang, Hongshang Hu, Wenhao Zhou, Jingxian Gongye, Ting Wang, Juan Xu
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Tetrahedral Boronate Ester as Regulators of Inflammation and Adhesion in ox-LDL Induced Atherosclerotic Model Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 U. Degirmenci, A. Kilic, R. Söylemez, M. Yildirim
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Synthesis of Novel 2-((3-(Benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl-4-phenylthiazole: Potent EGFR Targeting Anticancer Agents Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 Sateesh Amudala, Rambabu Palabindela, Srinu Bhoomandla, N Kotilingaiah, Jonnala Sandhya, Jyothi Mandala
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Effective Microwave-Assisted Synthesis of 2-Chloro-5,6-dimethyl-3-(((substituted-benzylidene)hydrazono)methyl)-quinoline and Its Biological Assessment Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 N. K. Vegal, T. D. Bhatt, K. Kachhot, H. S. Joshi
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Synthesis of Chromeno[2,3-d]pyrimidine-2,4(3H)-dion Derivatives Fused with Indole Moiety as Potent Biological Agents Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 P. V. Navaneethgowda, Y. D. Bodke, B. Manjunatha, N. D. Satyanarayan, N. B. Nippu
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Synthesis, Spectral Identification of Some New Schiff Bases, and Evaluation of Their Antibacterial Activity and Inhibitory Effect on Proinflammatory Cytokines (IL-1β, TNF), and DNA Ligase Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 Israa A. Alhasan Hamdan, Alaa Abd Alhasan Hamdan, Rasha A. Abidalmutalib Aljabawi
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Isolation, Physico-Chemical Characteristics, and Acute Toxicity Evaluation of Water-Soluble Polysaccharide from Basidial Raw Material Ganoderma lucidum Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 S. B. Khaytmetova, A. S. Turaev, G. A. Khalilova, B. I. Muhitdinov
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Acetylcholine Inhibitory Study of Novel Thio Linked Coumarin-Benzimidazole Derivatives: Design, Synthesis, Computational, and In Silico Molecular Docking Studies Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 T. H. Maruthi Nayaka, Itte Pushpavathi, Pavithra, Y. R. Nagesh
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Participation of the Transcription Factor CREB1 in the Regulation of the Mdh2 Gene Encoding Malate Dehydrogenase in the Liver of Rats with Alloxan-Induced Diabetes Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 A. T. Eprintsev, K. R. Romanenko, N. V. Selivanova
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A New Approach to the Synthesis of Anti-Reverse Cap Analog (ARCA) 2mGpppG Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-13 A. L. Kayushin, K. V. Antonov, E. V. Dorofeeva, M. Ya. Berzina, A. O. Arnautova, I. A. Prohorenko, A. I. Miroshnikov, I. D. Konstantinova
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Design and Synthesis of Benzo-Spirocyclic Derivatives as Potent PARP-1 Inhibitors Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-01
Abstract ctive: In this study, we further explored the discovery of novel PARP-1 inhibitors based on previous studies. We designed and synthesized 6 compounds with different structures, which further enriched the structural types of novel PARP-1 inhibitors. Methods: Firstly, the structures of all target compounds were determined by 1H NMR, 13C NMR, and high resolution MS. Next, the target compounds
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Synthesis of Steroid Tracers by an Oxime Ligation Method and Their Use in Fluorescent Polarisation Immunoassay Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-01
Abstract ctive: The development of a fast and reliable method for the quantitative evaluation of steroid hormones is very relevant for scientific and clinical research. The goal of this study was to develop a new universal method for the synthesis of fluorescent tracers from carbonyl-containing biomolecules by oxime ligation. Methods: A method for the synthesis of ketosteroid oxime conjugates with
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Synthesis and Anti-Mycobacterium Activity of Some New N-Rich Heterocyclic Derivatives and Their Molecular Docking, and DFT Studies Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-01
Abstract Objective: Synthesis of N-rich heterocyclic derivatives; anti-TB activity, molecular docking, ADME-T, and computational studies. Methods: Synthesis was carried out by conventional method; structures of synthesised was confirmed by different spectroscopic methods; evaluation of anti-TB activity was done by Microplate Alamar Blue assay (MABA); Molecular docking was analyzed by using ChemBioDraw
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Synthesis, Characterization, and Study of Anticancer Activities of New Schiff Bases and 1,3-Oxazepine Containing Drug Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-01
Abstract Objective: This study involved the synthesis of new Schiff bases and 1,3-oxazepine derivatives from the baclofen drug and study the anticancer activities. Methods: Baclofen was initially reacted with aromatic aldehydes to create Schiff base derivatives (Ia–Ib), which were then closed in the next step using anhydrous acids to form oxazepine derivatives (IIa–IId). Results: The title compounds
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Surfactants as a Means of Delivering a Reporter Genetic Construct Based on Binase Suicide Gene to Tumor Cells Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-02-01
Abstract Objective: Among modern gene therapy methods for combating oncology, suicidal gene therapy based on the delivery of a cytotoxic agent to target cells is of particular importance and promise. As one of such genes, the gene for ribonuclease of Bacillus pumilus 7P, binase, can be considered; the enzyme has a high antitumor potential and low immunogenicity. In addition to the choice of a transgene
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Triazole Moieties as Potent Drug Molecules: Synthetic Approaches and Application as Promising Candidates as Anticancer Agents (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-01-10 V. K. Vashistha, A. Mittal, R. Bala, R. V. S. R. Pullabhotla
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Novel Quinoxaline Derivatives: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-01-10 Zhongde Xie, Xuelian Dai, Liqing Wang
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Synthesis of Novel Azabenzimidazole Bridged bis-Coumarin Compounds, Investigation of Pancreatic Lipase Inhibitory Properties, and Docking Studies Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-01-10 Gülay Akyüz, Özlem Faiz, Mustafa Emirik, Emre Menteşe
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A Brief Review on Schiff Base, Synthesis, and Their Antimicrobial Activities Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-01-10 Ruaa M. Dhedan, Sanaa A. Alsahib, Rana Abid Ali
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Synthesis of 6-Alkylamino-2-alkylthio(alkoxy) Purine Derivatives: Antiplatelet Aggregation Activity Evaluation and 3D-QSAR Analysis Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-01-10 Shunlai Li, Pengyu Zheng, Yajing Ren, Hongguang Du
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Synthesis, Structure, and In Vitro Pharmacological Evaluation of some New Pyrimidine-2-Sulfonamide Derivatives and Their Molecular Docking Studies on Human Estrogen Receptor Alpha and CDK2/Cyclin Proteins Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-01-10 Qassim A. H. Jaber, Ahmed Hassen Shentaif, Mohammed Almajidi, Iqrar Ahmad, Harun Patel, Abul Kalam Azad, Sulaiman Mohammed Alnasser, Hanan Ali Alatawi, Farid Menaa, Sulaiman Y.M. Alfaifi, Mohammed M. Rahman, Meser M. Ali, S. J. Aditya Rao
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Virtual Screening of Orally Active Lead Compounds of Pearl Millet and Their Structural Activity Against Target Protein of COVID-19 Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2024-01-10 Adarsh Kumar Shukla, Ashwani Kumar
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Huntington’s Disease Alters the Dermal Fibroblasts Secretome Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-28 M. Khotin, N. Kraskovskaya, P. Parfionova, N. Yudintceva, Y. Kolesnichenko, E. Ovcharenko, E. Repkin, S. Shabelnikov, A. Mittenberg, N. Mikhailova
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5-Alkyloxymethyl Derivatives of 2ʹ-Deoxyuridine Bearing 2,4-Dinitrophenyl and Dansyl Groups: Synthesis and Antibacterial Activity Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-28 D. A. Makarov, I. A. Oskolsky, M. V. Jasko, P. N. Solyev, B. F. Vasilyeva, M. V. Demiankova, O. V. Efremenkova, S. N. Kochetkov, L. A. Alexandrova
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Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-28 V. U. Kuksenok, V. V. Shtrykova, V. D. Filimonov, T. V. Shushpanova, N. A. Bokhan, L. Seilerová, B. Kratohvil, V. Sieberová
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Replicative Senescence in Human Embryo Bone Marrow MSCs is Characterized by Changes in Cell Motility and Subcellular Localization of Rac1 and RhoA GTPases Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-28 A. V. Lukacheva, A. I. Gorb, A. S. Musorina, D. V. Kriger, G. G. Poljanskaya, D. E. Bobkov
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Synthesis and Properties of Selenium Nanoparticles in a Natural Polysaccharide Matrix Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 D. A. Panov, A. M. Katsev, A. V. Omel’chenko
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Seasonal Changes in the Composition of Scots Pine (Pinus Syvestris L.) Oleoresin, Measured by the NMR Method Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 E. D. Skakovskii, L.Yu., E. I. Gapan’kova, I. A., E. H. Popoff, S. A. Lamotkin
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On the Possibility of Quantitative Determination of Lignin and Cellulose in Plant Materials Using IR Spectroscopy Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 S. G. Kostryukov, N. A. Malov, Yu. Yu. Masterova, Kh. B. Matyakubov, I. A. Konushkin, K. V. Savrasov, A. A. Pynenkov, N. A. Khluchina
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Component Composition and Antiradical Activity of Individual Fractions of Thymus Jenis-Seensis Iljin. Essential Oil Growing in the Krasnoyarsk Territory Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 A. A. Efremov, I. D. Zykova, D.G. Slashchinin
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Characterization of the Redox State of the Lignin-Carbohydrate Wood Matrix in the Initial Stages of Development Using the Example of Scots Pine Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 М. А. Gusakova, К. G. Bogolitsyn, А. А. Krasikova, N. V. Selivanova, S. S. Khviuzov
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Comparative Studies of the Chemical Interaction of Guanidine with Dialdehyde Cellu-Lose And Pectin Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 O. R. Akhmedov, Sh. A. Shomurotov, A. S. Turaev
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Composition of Lipophilic Components of Rhododendron adamsii Rehd. Ether Extract and Activity against SARS-CoV-2 Main Protease Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 T. P. Kukina, I. A. Elshin, O. I. Sal’nikova, P. V. Kolosov, Ts. Sandag, D. A. Karakai, M. A. Bondareva, A. A. Nefedov, V. Yu. Chirkova, E. A. Sharlaeva, S. V. Belen’kaya, D. N. Shcherbakov
Abstract The composition of the lipophilic components of Rhododendron adamsii Rehd. was studied. Acidic and neutral components were identified by gas chromatography-mass spectrometry. Methyl tert-butyl ether (MTBE), which offers all the advantages of diethyl ether but is free of its disadvantages, was used as the extraction solvent for the raw materials. It does not form peroxides or create increased
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Application of Rice (Oryza Sativa) Husk as a Sorption Material for the Removal of Pollutants from Aqueous Media (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 A. A. Kushnir, K. S. Sypko, A. S. Gubin, K. O. Sizo, P. T. Sukhanov
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Analysis of the Products of Extraction and Water-Alkaline Hydrolysis of Technical Birch Bark under Microwave EMF Exposure Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 E. N. Koptelova, N. A. Kutakova, S. I. Tret’yakov, A. V. Faleva
Abstract Research was carried out on the isolation of betulin and suberin from the debarking waste of the Arkhangelsk Pulp and Paper Mill pulpwood, ground on an abrasive crusher. Betulin was extracted from various fractions of technical bark with 86% ethanol under exposure to microwave electromagnetic field (EMF) (microwave extraction). Suberin was isolated from the extracted bark by hydrolysis with
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Phytochemical Analysis of Extractive Substances Extracted by Different Methods from the Underground Part of Aconitum Septentrionale L., and the Development of Cream-Gels Based on Them Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 A. V. Zakharchenko, N. G. Bazarnova, A. S. Orlova
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Chemical Composition and Pharmacological Activity of Aqueous Extract of Siberian Fir (Abies Sibirica L.) (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 V. N. Burkova, V. P. Sergun, A. A. Ivanov
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Structure of Cornel Cornel Fruits Anthocyanins (Cornus Mas) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 Ya. Yu. Salasina, N. S. Skrypnikov, V. I. Deineka, L. A. Deineka
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Biologically Active Substances and Antioxidant Activity of Some Plants of the Asteraceae Family, Cultivated in Conditions of Western Siberia Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 M. A. Lebedeva, T. A. Kukushkina, T. M. Shaldaeva, Yu. A. Pshenichkina, E. P. Khramova
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Investigation of the Supercritical CO2 Extracts of Wild Ledum Palustre L. (Rhododendron Tomentosum Harmaja) and Identification of Its Metabolites by Tandem Mass Spectrometry Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 M. P. Razgonova, A. M. Zakharenko, K. S. Golokhvast
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Functional Materials from Waste Paper. IV. Comparative Study of the Functional Composition, Supramolecular Structure, and Morphology of the Powder Celluloses Isolated from Waste Paper, Plant Celluloses, and Nonconventional Raw Materials Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 A. M. Mikhailidi, V. I. Markin, N. E. Kotel’nikova
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Flavonoids and Lignans of Nepeta multifida (Lamiaceae) Leaves and Their Biological Activity Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-25 N. I. Kashchenko, D. N. Olennikov
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Synthesis and Biological Evaluation of Fused [1,2,3]Triazolo[4ʹ,5ʹ:4,5]pyrido[2,3-d]pyrimidine Linked 1,2,3-Triazolesas Potent EGFR Targeting Anticancer Agents Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-01
Abstract Using 1-(4-nitrophenyl)-4,5-dihydro-1H-[1,2,3]triazolo[4ʹ,5ʹ:4,5]pyrido[2,3-d]pyrimidine and various aryl azides, we developed and synthesized a number of novel fused [1,2,3]triazolo[4ʹ,5ʹ:4,5]pyrido[2,3-d]pyrimidine linked 1,2,3-triazoles. The intermediate fused 1,2,3-triazole was synthesized by a click reaction followed by a C–C bond coupling process. The newly synthesized compounds were
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COX-2 Enzyme Inhibitors Study and Efficacy Pharmacokinetic by Molecular Docking for some New Heterocyclic Rings Driver from Levofloxacin Drug Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-01
Abstract Assay methods using cyclooxygenase fluorescence inhibitors and the standard drug levofloxacin were used to determine the anti-inflammatory profile of Triazole, Triazine derived from Levofloxacin compounds (IVa–IVe) that had been designed, synthesized, and subjected to in silico ADMET prediction, molecular docking, characterization by FT-IR, and 1H NMR analysis techniques. In addition to predicting
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Isolation of Dihydroquercetin and Arabinogalactan from Larch Wood by Water-Ethanol Solutions Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-01
Abstract Siberian larch wood (Larix sibirica Lebed.) contains such valuable biologically active substances as dihydroquercetin (DHQ) and arabinogalactan (AG), promising for the use in the pharmaceutical and food industries. An urgent task is to improve the methods of extraction isolation of these compounds from wood. In this work, we studied the possibility of simultaneous isolation of dihydroquercetin
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Lignin Valorization Problems (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-01
Abstract This review considered two directions of lignin valorization: valorization of technical lignins as such, not subjected to preliminary depolymerization, and their valorization through monomeric compounds resulted from selective lignin degradation. The first direction includes production of lignin hydrogels and use of lignin in medicine, pharmacology, and 3D printing, as well as in preparation
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Isolation and Characterization of the Hemicelluloses Polysaccharides of Scots Pine (Pinus Sylvestris) Wood Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-01
Abstract Many natural polysaccharides have biological activity, which allows them to be used for obtaining medicines. Development of new methods for the isolation of polysaccharides from plant materials, as well as investigation of their properties and structure constitute a topical task. In this study, polysaccharide galactoglucomannan (GGM) was isolated from pine wood for the first time by the peroxide
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Diagnostics of Early Changes in the Physicochemical Properties of Wood under the Influence of Fungal Infections Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-12-01
Abstract The sound wood and damaged wood of Pinus sylvestris L. in an early stage of the development of a fungal infection were studied using scanning electron microscopy, thermogravimetry, and pyrolysis-gas chromatography/mass spectrometry. Scanning electron microscopy showed the presence of fungal hyphae in tracheids of the damaged wood. The hyphae penetrated into the tracheids through the pores
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A Perspective of the Amide Group Containing FDA Approved Anticancer Drugs from 2021–2022 (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-11-23 Mohd Asif, Rohan Srivastava, Alisha Fatima, Mazhar Shakeel, Firoz Hassan, Malik Nasibullah
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Flavin-Dependent Dehydrogenases and Oxidases: Comparison of Structural Functional Properties (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-11-23 A. A. Chudin, E. V. Kudryashova
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Radiopharmaceuticals for Non-Glucose-Specific Oncology (PET and SPECT) (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-11-23 E. D. Belitskaya, V. A. Dimitreva, A. N. Kozlov, V. A. Oleinikov, A. V. Zalygyn
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Bacterial Adaptation Mechanisms to Stress Conditions with Small Non-Coding RNAs Participation (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-11-23 A. S. Karpov, D. A. Elkina, T. S. Oretskaya, E. A. Kubareva
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Recent Advances in Synthetic Aspects of Naringenin Flavonoid and its Bioprotective Effect (A Review) Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-11-23 A. Prasad, R. Kumar, S. Kumari
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Erratum to: Structural Analogs of Dehydrozingerone Containing a Pyridoxine Fragment Exhibit Membrane-Modulating Properties and Synergistically Enhance the Antitumor Activity of Cytostatics Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-11-23 O. V. Bondar, R. Karwt, T. Mohammad, R. S. Pavelyev, M. V. Pugachev, Be. B. Ygaiev, A. R. Kayumov, A. M. Aimaletdinov, Y. G. Shtyrlin
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Effeсts of the 70th Amino Acid Residue on the Photostability of FAST Complexes Russ. J. Bioorg. Chem. (IF 1.0) Pub Date : 2023-11-23 Yu. A. Bogdanova, K. S. Mineev, N. S. Baleeva, M. S. Baranov