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Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate RSC Chem. Biol. Pub Date : 2021-1-15 Maxime Couturier; Hiral D. Bhalara; Rita E. Monson; George P. C. Salmond; Finian J. Leeper
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Site-specific single point mutation by anthranilic acid in hIAPP8–37 enhances anti-amyloidogenic activity RSC Chem. Biol. Pub Date : 2021-1-15 Sourav Kalita; Sujan Kalita; Ashim Paul; Manisha Shah; Sachin Kumar; Bhubaneswar Mandal
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Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme RSC Chem. Biol. Pub Date : 2021-1-15 Christopher J. Harding; Emmajay Sutherland; Jane G. Hanna; Douglas R. Houston; Clarissa M. Czekster
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Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration RSC Chem. Biol. Pub Date : 2021-1-14 Alexander L. Nielsen; Nima Rajabi; Norio Kudo; Kathrine Lundø; Carlos Moreno-Yruela; Michael Bæk; Martin Fontenas; Alessia Lucidi; Andreas S. Madsen; Minoru Yoshida; Christian A. Olsen
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The pursuit of mechanism of action: uncovering drug complexity in TB drug discovery RSC Chem. Biol. Pub Date : 2021-1-13 Tianao Yuan; Joshua M. Werman; Nicole S. Sampson
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Substrate inhibition by the blockage of product release and its control by tunnel engineering RSC Chem. Biol. Pub Date : 2021-1-11 Piia Kokkonen; Andy Beier; Stanislav Mazurenko; Jiri Damborsky; David Bednar; Zbynek Prokop
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Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein RSC Chem. Biol. Pub Date : 2021-1-6 Amirrasoul Tavakoli; Debamita Paul; Hong Mu; Jagannath Kuchlyan; Saroj Baral; Anjum Ansari; Suse Broyde; Jung-Hyun Min
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Protein degradation profile reveals dynamic nature of 20S proteasome small molecule stimulation RSC Chem. Biol. Pub Date : 2021-1-5 Rachel A. Coleman; Rodrigo Mohallem; Uma K. Aryal; Darci J. Trader
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Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications RSC Chem. Biol. Pub Date : 2021-1-5 Gerhard Niederacher; Debra Urwin; Yasmin Dijkwel; David J. Tremethick; K. Johan Rosengren; Christian F. W. Becker; Anne C. Conibear
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Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor RSC Chem. Biol. Pub Date : 2021-1-5 Kaho Suzuki; Yousuke Takaoka; Minoru Ueda
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The chemical biology of coronavirus host–cell interactions RSC Chem. Biol. Pub Date : 2020-12-23 Suprama Datta; Erik C. Hett; Kalpit A. Vora; Daria J. Hazuda; Rob C. Oslund; Olugbeminiyi O. Fadeyi; Andrew Emili
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Mapping the energy landscape of protein–ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion RSC Chem. Biol. Pub Date : 2020-12-23 Olof Stenström; Carl Diehl; Kristofer Modig; Ulf J. Nilsson; Mikael Akke
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Generation of glucosylated sn-1-glycerolphosphate teichoic acids: glycerol stereochemistry affects synthesis and antibody interaction RSC Chem. Biol. Pub Date : 2020-12-23 Francesca Berni; Liming Wang; Ermioni Kalfopoulou; D. Linh Nguyen; Daan van der Es; Johannes Huebner; Herman S. Overkleeft; Cornelis H. Hokke; Gijsbert A. van der Marel; Angela van Diepen; Jeroen D. C. Codée
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Biosynthesis of alkyne-containing natural products RSC Chem. Biol. Pub Date : 2020-12-21 Xinyang Li; Jian-Ming Lv; Dan Hu; Ikuro Abe
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A STING-based fluorescent polarization assay for monitoring activities of cyclic dinucleotide metabolizing enzymes RSC Chem. Biol. Pub Date : 2020-12-17 Caroline W. Karanja; Kofi S. Yeboah; Wilson W. S. Ong; Herman O. Sintim
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In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides RSC Chem. Biol. Pub Date : 2020-12-16 Joseph M. Rogers; Mickal Nawatha; Betsegaw Lemma; Ganga B. Vamisetti; Ido Livneh; Uri Barash; Israel Vlodavsky; Aaron Ciechanover; David Fushman; Hiroaki Suga; Ashraf Brik
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Fluorescence lifetime predicts performance of voltage sensitive fluorophores in cardiomyocytes and neurons RSC Chem. Biol. Pub Date : 2020-12-11 Steven C. Boggess; Julia R. Lazzari-Dean; Benjamin K. Raliski; Dong Min Mun; Amy Y. Li; Joshua L. Turnbull; Evan W. Miller
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Finding and characterizing a catalytic antibody light chain, H34, capable of degrading the PD-1 molecule RSC Chem. Biol. Pub Date : 2020-12-10 Emi Hifumi; Hiroaki Taguchi; Tamami Nonaka; Takunori Harada; Taizo Uda
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In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery RSC Chem. Biol. Pub Date : 2020-11-19 Lesley Ann Howell; Andrew Michael Beekman
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Transfer hydrogenation catalysis in cells RSC Chem. Biol. Pub Date : 2020-11-5 Samya Banerjee; Peter J. Sadler
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A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions RSC Chem. Biol. Pub Date : 2020-11-3 Han Yao; Chushu Li; Fang He; Teng Song; Jean-Philippe Brosseau; Huanbin Wang; Haojie Lu; Caiyun Fang; Hubing Shi; Jiang Lan; Jing-Yuan Fang; Jie Xu
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Immunopharmacotherapeutic advancements in addressing methamphetamine abuse RSC Chem. Biol. Pub Date : 2020-10-8 Jinny Claire Lee; Kim D. Janda
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A live-cell assay for the detection of pre-microRNA–protein interactions RSC Chem. Biol. Pub Date : 2020-12-8 Sydney L. Rosenblum; Daniel A. Lorenz; Amanda L. Garner
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Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery RSC Chem. Biol. Pub Date : 2020-12-8 Marta Pazo; Giulia Salluce; Irene Lostalé-Seijo; Marisa Juanes; Francisco Gonzalez; Rebeca Garcia-Fandiño; Javier Montenegro
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Strategies to expand peptide functionality through hybridisation with a small molecule component RSC Chem. Biol. Pub Date : 2020-12-8 Yuteng Wu; Jack Williams; Ewen D. D. Calder; Louise J. Walport
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Modified internucleoside linkages for nuclease-resistant oligonucleotides RSC Chem. Biol. Pub Date : 2020-12-8 Guillaume Clavé; Maeva Reverte; Jean-Jacques Vasseur; Michael Smietana
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A two-step resin based approach to reveal survivin-selective fluorescent probes RSC Chem. Biol. Pub Date : 2020-11-27 Andrew J. Ambrose; Nhan T. Pham; Jared Sivinski; Larissa Guimarães; Niloufar Mollasalehi; Paula Jimenez; Maria A. Abad; A. Arockia Jeyaprakash; Steven Shave; Letícia V. Costa-Lotufo; James J. La Clair; Manfred Auer; Eli Chapman
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Aquaporin-driven hydrogen peroxide transport: a case of molecular mimicry? RSC Chem. Biol. Pub Date : 2020-11-25 Darren Wragg; Stefano Leoni; Angela Casini
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Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistance RSC Chem. Biol. Pub Date : 2020-11-17 M. Rhia L. Stone; Urszula Łapińska; Stefano Pagliara; Muriel Masi; Joanne T. Blanchfield; Matthew A. Cooper; Mark A. T. Blaskovich
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Dehydroamino acid chemical biology: an example of functional group interconversion on proteins RSC Chem. Biol. Pub Date : 2020-11-06 Lyn H. Jones
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Combining bacteriophage engineering and linear dichroism spectroscopy to produce a DNA hybridisation assay RSC Chem. Biol. Pub Date : 2020-10-23 Aysha Ali; Haydn A. Little; Jake G. Carter; Craig Douglas; Matthew R. Hicks; David M. Kenyon; Christophe Lacomme; Richard T. Logan; Timothy R. Dafforn; James H. R. Tucker
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Cyclic peptide scaffold with ability to stabilize and deliver a helical cell-impermeable cargo across membranes of cultured cancer cells RSC Chem. Biol. Pub Date : 2020-10-20 Nicole Lawrence; Grégoire J.-B. Philippe; Peta J. Harvey; Nicholas D. Condon; Aurélie H. Benfield; Olivier Cheneval; David J. Craik; Sónia Troeira Henriques
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Artificial imine reductases: developments and future directions RSC Chem. Biol. Pub Date : 2020-10-16 Rosalind L. Booth; Gideon Grogan; Keith S. Wilson; Anne-Kathrin Duhme-Klair
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In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia RSC Chem. Biol. Pub Date : 2020-09-23 Sophie V. Morse; Tamara Boltersdorf; Tiffany G. Chan; Felicity N. E. Gavins; James J. Choi; Nicholas J. Long
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Chemical synthesis of a haemathrin sulfoprotein library reveals enhanced thrombin inhibition following tyrosine sulfation RSC Chem. Biol. Pub Date : 2020-09-21 Daniel Clayton; Sameer S. Kulkarni; Jessica Sayers; Luke J. Dowman; Jorge Ripoll-Rozada; Pedro José Barbosa Pereira; Richard J. Payne
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Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels RSC Chem. Biol. Pub Date : 2020-09-18 Claudia C. Bauer; Aisling Minard; Isabelle B. Pickles; Katie J. Simmons; Eulashini Chuntharpursat-Bon; Matthew P. Burnham; Nikil Kapur; David J. Beech; Stephen P. Muench; Megan H. Wright; Stuart L. Warriner; Robin S. Bon
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Illuminating glycoscience: synthetic strategies for FRET-enabled carbohydrate active enzyme probes RSC Chem. Biol. Pub Date : 2020-09-17 Meenakshi Singh; Michael Watkinson; Eoin M. Scanlan; Gavin J. Miller
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Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors RSC Chem. Biol. Pub Date : 2020-09-16 Grace E. Hubbell; Jetze J. Tepe
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Modified nucleoside triphosphates in bacterial research for in vitro and live-cell applications RSC Chem. Biol. Pub Date : 2020-09-14 Adeline Espinasse; Hannah K. Lembke; Angela A. Cao; Erin E. Carlson
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Met80 and Tyr67 affect the chemical unfolding of yeast cytochrome c: comparing the solution vs. immobilized state RSC Chem. Biol. Pub Date : 2020-09-09 Alessandro Paradisi; Lidia Lancellotti; Marco Borsari; Marzia Bellei; Carlo Augusto Bortolotti; Giulia Di Rocco; Antonio Ranieri; Marco Sola; Gianantonio Battistuzzi
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Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors RSC Chem. Biol. Pub Date : 2020-08-28 João D. Seixas; Bárbara B. Sousa; Marta C. Marques; Ana Guerreiro; Rui Traquete; Tiago Rodrigues; Inês S. Albuquerque; Marcos F. Q. Sousa; Ana R. Lemos; Pedro M. F. Sousa; Tiago M. Bandeiras; Di Wu; Shelby K. Doyle; Carol V. Robinson; Angela N. Koehler; Francisco Corzana; Pedro M. Matias; Gonçalo J. L. Bernardes
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Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding RSC Chem. Biol. Pub Date : 2020-08-28 Jonathan Cramer; Xiaohua Jiang; Wojciech Schönemann; Marleen Silbermann; Pascal Zihlmann; Stefan Siegrist; Brigitte Fiege; Roman Peter Jakob; Said Rabbani; Timm Maier; Beat Ernst
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Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint RSC Chem. Biol. Pub Date : 2020-08-27 Kuan Hu; Lin Xie; Masayuki Hanyu; Yiding Zhang; Lingyun Li; Xiaohui Ma; Kotaro Nagatsu; Hisashi Suzuki; Weizhi Wang; Ming-Rong Zhang
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Activatable cell-penetrating peptides: 15 years of research RSC Chem. Biol. Pub Date : 2020-08-26 Heleen de Jong; Kimberly M. Bonger; Dennis W. P. M. Löwik
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Cellular internalization mechanism of novel Raman probes designed for plant cells RSC Chem. Biol. Pub Date : 2020-08-20 Keiko Midorikawa; Kousuke Tsuchiya; Simon Sau Yin Law; Yu Miyagi; Takuya Asai; Takanori Iino; Yasuyuki Ozeki; Yutaka Kodama; Keiji Numata
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Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents RSC Chem. Biol. Pub Date : 2020-08-19 Debabrata Maity; Sunil Kumar; Ruyof AlHussein; Lothar Gremer; Madeline Howarth; Laura Karpauskaite; Wolfgang Hoyer; Mazin Magzoub; Andrew D. Hamilton
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A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families RSC Chem. Biol. Pub Date : 2020-08-18 Taylor A. Lundy; Shogo Mori; Sylvie Garneau-Tsodikova
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Long-range PEG stapling: macrocyclization for increased protein conformational stability and resistance to proteolysis RSC Chem. Biol. Pub Date : 2020-08-13 Qiang Xiao; Dallin S. Ashton; Zachary B. Jones; Katherine P. Thompson; Joshua L. Price
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Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping RSC Chem. Biol. Pub Date : 2020-08-12 Jonas Drechsel; Christina Kyrousi; Silvia Cappello; Stephan A. Sieber
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Fluorescent small-molecule agonists as follicle-stimulating hormone receptor imaging tools RSC Chem. Biol. Pub Date : 2020-08-03 Sascha Hoogendoorn; Gijs H. M. van Puijvelde; Gijs A. van der Marel; Chris J. van Koppen; C. Marco Timmers; Herman S. Overkleeft
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DNA folds threaten genetic stability and can be leveraged for chemotherapy RSC Chem. Biol. Pub Date : 2020-9-30 Joanna Zell; Francesco Rota Sperti; Sébastien Britton; David Monchaud
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Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases RSC Chem. Biol. Pub Date : 2020-07-28 Casper de Boer; Nicholas G. S. McGregor; Evert Peterse; Sybrin P. Schröder; Bogdan I. Florea; Jianbing Jiang; Jos Reijngoud; Arthur F. J. Ram; Gilles P. van Wezel; Gijsbert A. van der Marel; Jeroen D. C. Codée; Herman S. Overkleeft; Gideon J. Davies
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Antibacterial activity of a dual peptide targeting the Escherichia coli sliding clamp and the ribosome RSC Chem. Biol. Pub Date : 2020-07-16 Christophe André; Florian Veillard; Philippe Wolff; Anne-Marie Lobstein; Guillaume Compain; Clément Monsarrat; Jean-Marc Reichhart; Camille Noûs; Dominique Y. Burnouf; Gilles Guichard; Jérôme E. Wagner
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Matters of class: coming of age of class III and IV lanthipeptides RSC Chem. Biol. Pub Date : 2020-07-16 Julian D. Hegemann; Roderich D. Süssmuth
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Haemoglobin(βK120C)–albumin trimer as an artificial O2 carrier with sufficient haemoglobin allostery RSC Chem. Biol. Pub Date : 2020-07-13 Yoshitsugu Morita; Asuka Saito; Jun Yamaguchi; Teruyuki Komatsu
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Tools for functional dissection of site-specific O-GlcNAcylation RSC Chem. Biol. Pub Date : 2020-06-12 Andrii Gorelik; Daan M. F. van Aalten
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Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry RSC Chem. Biol. Pub Date : 2020-06-02 Dorothée Ganz; Dennis Harijan; Hans-Achim Wagenknecht
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The chemical biology of IL-12 production via the non-canonical NFkB pathway RSC Chem. Biol. Pub Date : 2020-07-22 Peter D. Koch; Mikael J. Pittet; Ralph Weissleder
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Harnessing cyclotides to design and develop novel peptide GPCR ligands RSC Chem. Biol. Pub Date : 2020-07-22 Edin Muratspahić; Johannes Koehbach; Christian W. Gruber; David J. Craik
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Biological Evaluation of Native Streptococcal Competence Stimulating Peptides Reveal Potential Crosstalk Between Streptococcus mitis and Streptococcus pneumoniae and a New Scaffold for the Development of S. pneumoniae Quorum Sensing Modulators. RSC Chem. Biol. Pub Date : 2020-05-29 Tahmina Ahmed Milly,Yftah Tal-Gan
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