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Molecularly imprinted nanoparticles reveal regulatory scaffolding features in Pyk2 tyrosine kinase RSC Chem. Biol. Pub Date : 2024-03-13 Tania M Palhano Zanela, Milad Zangiabadi, Yan Zhao, Eric Underbakke
Pyk2 is a multi-domain non-receptor tyrosine kinase that serves dual roles as signaling enzyme and scaffold. Pyk2 activation involves a multi-stage cascade of conformational rearrangements and protein interactions initiated by autophosphorylation of a linker site. Linker phosphorylation recruits Src kinase, and Src-mediated phosphorylation of the Pyk2 activation loop confers full activation. The regulation
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Leveraging machine learning models for peptide–protein interaction prediction RSC Chem. Biol. Pub Date : 2024-03-13 Song Yin, Xuenan Mi, Diwakar Shukla
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Discovery of Potent and Selective Activity-Based Probes (ABPs) for the Deubiquitinating Enzyme USP30 RSC Chem. Biol. Pub Date : 2024-03-13 Milon Mondal, Fangyuan Cao, Daniel Paul Conole, Holger Werner Auner, Edward William Tate
Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) localized at the mitochondrial outer membrane and involved in PINK1/Parkin-mediated mitophagy, pexophagy, BAX/BAK-dependent apoptosis, and IKKβ-USP30-ACLY-regulated lipogenesis/tumorigenesis. A USP30 inhibitor, MTX652, has recently entered clinical trials as a potential treatment for mitochondrial dysfunction. Small molecule
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Introduction to ‘The Epitranscriptome’ RSC Chem. Biol. Pub Date : 2024-03-06 Ralph E. Kleiner, Claudia Höbartner, Guifang Jia
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Engineering cell-free systems by chemoproteomic-assisted phenotypic screening RSC Chem. Biol. Pub Date : 2024-03-06 Zarina Levitskaya, Zheng Ser, Hiromi Koh, Wang Shi Mei, Sharon Chee, Radoslaw Mikolaj Sobota, John F. Ghadessy
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Development of PCR primers enabling the design of flexible sticky ends for efficient concatenation of long DNA fragments RSC Chem. Biol. Pub Date : 2024-02-26 Kohei Nomura, Kaoru Onda, Hirotaka Murase, Fumitaka Hashiya, Yukiteru Ono, Goro Terai, Natsuhisa Oka, Kiyoshi Asai, Daisuke Suzuki, Naho Takahashi, Haruka Hiraoka, Masahito Inagaki, Yasuaki Kimura, Yoshihiro Shimizu, Naoko Abe, Hiroshi Abe
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Tracking the cellular uptake and phototoxicity of Ru(II)-polypyridyl-1,8-naphthalimide Tröger's base conjugates RSC Chem. Biol. Pub Date : 2024-02-21 Sandra A. Bright, MariaLuisa Erby, Fergus E. Poynton, Daniel Monteyne, David Pérez-Morga, Thorfinnur Gunnlaugsson, D. Clive Williams, Robert B. P. Elmes
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A covalent compound selectively inhibits RNA demethylase ALKBH5 rather than FTO RSC Chem. Biol. Pub Date : 2024-02-19 Gan-Qiang Lai, Yali Li, Heping Zhu, Tao Zhang, Jing Gao, Hu Zhou, Cai-Guang Yang
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Strategies for converting turn-motif and cyclic peptides to small molecules for targeting protein–protein interactions RSC Chem. Biol. Pub Date : 2024-02-16 Deanne Hayward, Andrew M. Beekman
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Sortase mediated protein ubiquitination with defined chain length and topology RSC Chem. Biol. Pub Date : 2024-02-07 Nicole R. Raniszewski, Jenna N. Beyer, Myles I. Noel, George M. Burslem
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Biomedical applications, perspectives and tag design concepts in the cell – silent Raman window RSC Chem. Biol. Pub Date : 2024-02-12 Martha Z. Vardaki, Vasilis G. Gregoriou, Christos L. Chochos
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Unusual cysteine modifications in natural product biosynthesis RSC Chem. Biol. Pub Date : 2024-02-09 Yaojie Gao, Yuhao Zhu, Takayoshi Awakawa, Ikuro Abe
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Genetically encodable biosensors for Ras activity RSC Chem. Biol. Pub Date : 2024-02-07 Ryan Weeks, Sohum Mehta, Jin Zhang
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Reversible oxidative dimerization of 4-thiouridines in tRNA isolates RSC Chem. Biol. Pub Date : 2024-02-01 Larissa Bessler, Jonathan Groß, Christopher J. Kampf, Till Opatz, Mark Helm
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Cell penetration of oxadiazole-containing macrocycles RSC Chem. Biol. Pub Date : 2024-01-15 Sungjoon Huh, Nefeli Batistatou, Jing Wang, George J. Saunders, Joshua A. Kritzer, Andrei K. Yudin
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Introduction to the themed collection on ‘Molecular and Nanotheranostics’ RSC Chem. Biol. Pub Date : 2024-01-12 Thimmaiah Govindaraju
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Evaluating Riboglow-FLIM probes for RNA sensing RSC Chem. Biol. Pub Date : 2024-01-08 Nadia Sarfraz, Luke K. Shafik, Zachary R. Stickelman, Uma Shankar, Emilia Moscoso, Esther Braselmann
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Click chemistry in the development of PROTACs RSC Chem. Biol. Pub Date : 2023-12-29 Ce Yang, Ravi Tripathi, Binghe Wang
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Engineered triphenylphosphonium-based, mitochondrial-targeted liposomal drug delivery system facilitates cancer cell killing actions of chemotherapeutics RSC Chem. Biol. Pub Date : 2023-12-21 Subramaniyam Sivagnanam, Kiran Das, Ieshita Pan, Adele Stewart, Atanu Barik, Biswanath Maity, Priyadip Das
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Sialic acids in infection and their potential use in detection and protection against pathogens RSC Chem. Biol. Pub Date : 2023-12-19 Simone Dedola, Sanaz Ahmadipour, Peterson de Andrade, Alexander N. Baker, Andrew N. Boshra, Simona Chessa, Matthew I. Gibson, Pedro J. Hernando, Irina M. Ivanova, Jessica E. Lloyd, María J. Marín, Alexandra J. Munro-Clark, Giulia Pergolizzi, Sarah-Jane Richards, Iakovia Ttofi, Ben A. Wagstaff, Robert A. Field
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Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening RSC Chem. Biol. Pub Date : 2023-12-18 Gloria Ortiz, James E. Longbotham, Sophia L. Qin, Meng Yao Zhang, Gregory M. Lee, R. Jeffrey Neitz, Mark J. S. Kelly, Michelle R. Arkin, Danica Galonić Fujimori
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BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium RSC Chem. Biol. Pub Date : 2023-12-11 Maria C. Lucana, Roberta Lucchi, Fabien Gosselet, Cristina Díaz-Perlas, Benjamí Oller-Salvia
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Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome C in cancer therapy RSC Chem. Biol. Pub Date : 2023-11-24 Ankita Sarkar, Sanchita Sarkhel, Deepali Bisht, Amit Jaiswal
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Bioluminescent detection of viral surface proteins using branched multivalent protein switches RSC Chem. Biol. Pub Date : 2023-11-23 Alexander Gräwe, Cindy M. Spruit, Robert P. de Vries, Maarten Merkx
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N 4-Allylcytidine: a new nucleoside analogue for RNA labelling and chemical sequencing RSC Chem. Biol. Pub Date : 2023-11-22 Tengwei Li, Xiao Shu, Minsong Gao, Chenyang Huang, Ting Li, Jie Cao, Xiner Ying, Donghong Liu, Jianzhao Liu
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Discovery and engineering of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products RSC Chem. Biol. Pub Date : 2023-11-21 He Li, Wei Ding, Qi Zhang
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Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis RSC Chem. Biol. Pub Date : 2023-11-14 Thomas P. Smith, Bhaskar Bhushan, Daniele Granata, Christian S. Kaas, Birgitte Andersen, Klaas W. Decoene, Qiansheng Ren, Haimo Liu, Xinping Qu, Yang Yang, Jia Pan, Quijia Chen, Martin Münzel, Akane Kawamura
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Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum RSC Chem. Biol. Pub Date : 2023-11-13 Monika Lisauskaitė, Gemma L. Nixon, Christopher M. Woodley, Neil G. Berry, Andy Coninckx, L. Charlie Qie, Suet C. Leung, Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, Stephen A. Ward, Oscar Vadas, Dominique Soldati-Favre, W. David Hong, Paul M. O'Neill
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Monitoring host–pathogen interactions using chemical proteomics RSC Chem. Biol. Pub Date : 2023-11-10 Angela Weigert Muñoz, Weining Zhao, Stephan A. Sieber
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Helix-based screening with structure prediction using artificial intelligence has potential for the rapid development of peptide inhibitors targeting class I viral fusion RSC Chem. Biol. Pub Date : 2023-11-07 Satoshi Suzuki, Mio Kuroda, Keisuke Aoki, Kumi Kawaji, Yoshiki Hiramatsu, Mina Sasano, Akie Nishiyama, Kazutaka Murayama, Eiichi N. Kodama, Shinya Oishi, Hironori Hayashi
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An AIE-based monofunctional Pt(II) complex for photodynamic therapy through synergism of necroptosis–ferroptosis RSC Chem. Biol. Pub Date : 2023-11-06 Xiaoxue Zheng, Minglun Liu, Yanping Wu, Yuncong Chen, Weijiang He, Zijian Guo
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Increasing the functional density of threose nucleic acid RSC Chem. Biol. Pub Date : 2023-10-25 Biju Majumdar, Daisy Sarma, Yutong Yu, Adriana Lozoya-Colinas, John C. Chaput
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Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein RSC Chem. Biol. Pub Date : 2023-10-24 H. T. Henry Chan, Lennart Brewitz, Petra Lukacik, Claire Strain-Damerell, Martin A. Walsh, Christopher J. Schofield, Fernanda Duarte
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An enhanced biophysical screening strategy to investigate the affinity of ASOs for their target RNA RSC Chem. Biol. Pub Date : 2023-10-23 Rouven Stulz, Michael Lerche, Olivia Luige, Agnes Taylor, Stefan Geschwindner, Alice Ghidini
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Small molecule modulators of immune pattern recognition receptors RSC Chem. Biol. Pub Date : 2023-10-23 Taku Tsukidate, Charles W. Hespen, Howard C. Hang
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Copper binding and protein aggregation: a journey from the brain to the human lens RSC Chem. Biol. Pub Date : 2023-10-17 Yanahi Posadas, Carolina Sánchez-López, Liliana Quintanar
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A cell-permeable probe for the labelling of a bacterial glycosyltransferase and virulence factor RSC Chem. Biol. Pub Date : 2023-10-19 Yong Xu, Gerd K. Wagner
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Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution RSC Chem. Biol. Pub Date : 2023-10-19 Mia Kapun, F. Javier Pérez-Areales, Nicola Ashman, Pamela J. E. Rowling, Tim Schober, Elaine Fowler, Laura S. Itzhaki, David R. Spring
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A unique binding mode of P1′ Leu-containing target sequences for Streptococcus pyogenes sortase A results in alternative cleavage RSC Chem. Biol. Pub Date : 2023-10-18 Brandon A. Vogel, Jadon M. Blount, Hanna M. Kodama, Noah J. Goodwin-Rice, Devin J. Andaluz, Sophie N. Jackson, John M. Antos, Jeanine F. Amacher
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Covalent targeting of non-cysteine residues in PI4KIIIβ RSC Chem. Biol. Pub Date : 2023-10-17 Brett Cosgrove, Emma K. Grant, Sophie Bertrand, Kenneth D. Down, Don O. Somers, John P. Evans, Nicholas C. O. Tomkinson, Michael D. Barker
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Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue RSC Chem. Biol. Pub Date : 2023-10-14 Oliver Hennrich, Leoni Weinmann, Andreas Kulik, Karen Harms, Philipp Klahn, Jung-Won Youn, Frank Surup, Yvonne Mast
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Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein RSC Chem. Biol. Pub Date : 2023-10-11 Clare Jelinska, Srinivasaraghavan Kannan, Yuri Frosi, Siti Radhiah Ramlan, Fernaldo Winnerdy, Rajamani Lakshminarayanan, Charles W Johannes, Christopher J Brown, Anh-Tuan Phan, Daniela Rhodes, Chandra S Verma
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Quantitative mass spectrometric analysis of hepatocellular carcinoma biomarker alpha-fetoprotein RSC Chem. Biol. Pub Date : 2023-10-09 Chen-Chun Chen, Han-Wen Huang, Bo-Rui Chen, Chi-Huey Wong
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Reduction-cleavable desferrioxamine B pulldown system enriches Ni(II)-superoxide dismutase from a Streptomyces proteome RSC Chem. Biol. Pub Date : 2023-10-02 Jenny Ni, James L. Wood, Melanie Y. White, Norbert Lihi, Todd E. Markham, Joseph Wang, Peter T. Chivers, Rachel Codd
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Bringing enzymes to the proximity party RSC Chem. Biol. Pub Date : 2023-09-29 Gabrielle S. Tender, Carolyn R. Bertozzi
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Unlocking the potential of platinum drugs: organelle-targeted small-molecule platinum complexes for improved anticancer performance RSC Chem. Biol. Pub Date : 2023-10-03 Zhiqin Deng, Shu Chen, Gongyuan Liu, Guangyu Zhu
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Single-chain multicolor-reporter templates for subcellular localization of molecular events in mammalian cells RSC Chem. Biol. Pub Date : 2023-10-03 Sung-Bae Kim, Ramasamy Paulmurugan, Nobuo Kitada, Sojiro A. Maki
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A strategy for orthogonal deubiquitination using a bump-and-hole approach RSC Chem. Biol. Pub Date : 2023-10-02 Takumi Suzuki, Yuki Utsugi, Satoshi Yamanaka, Hirotaka Takahashi, Yusuke Sato, Tatsuya Sawasaki, Yusaku Miyamae
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Red-shifted activity-based sensors for ethylene via direct conjugation of fluorophore to metal–carbene RSC Chem. Biol. Pub Date : 2023-09-25 Nicholas J. Dacon, Nathan B. Wu, Brian W. Michel
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Evaluation of Kdo-8-N3 incorporation into lipopolysaccharides of various Escherichia coli strains RSC Chem. Biol. Pub Date : 2023-09-26 Zeynep Su Ziylan, Geert-Jan de Putter, Meike Roelofs, Jan Maarten van Dijl, Dirk-Jan Scheffers, Marthe T. C. Walvoort
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Fluorescent naphthalimide boronates as theranostics: structural investigations, confocal fluorescence and multiphoton fluorescence lifetime imaging microscopy in living cells RSC Chem. Biol. Pub Date : 2023-09-18 Megan J. Green, Haobo Ge, Stephen E. Flower, Charareh Pourzand, Stanley W. Botchway, Hui-Chen Wang, Navaratnarajah Kuganathan, Gabriele Kociok-Köhn, Meng Li, Suying Xu, Tony D. James, Sofia I. Pascu
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Amphiphilic dendrons as supramolecular holdase chaperones RSC Chem. Biol. Pub Date : 2023-09-08 Elizabeth R. Piedmont, Erin E. Christensen, Todd D. Krauss, Benjamin E. Partridge
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Protein conformational ensembles in function: roles and mechanisms RSC Chem. Biol. Pub Date : 2023-09-05 Ruth Nussinov, Yonglan Liu, Wengang Zhang, Hyunbum Jang
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Binding affinity-based intracellular drug detection enabled by a unimolecular cucurbit[7]uril-dye conjugate RSC Chem. Biol. Pub Date : 2023-09-07 Yanxi Liu, Changming Hu, Julian A. Serna, Frank Biedermann, Pavel A. Levkin
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Biosynthesis of the fungal nonribosomal peptide penilumamide A and biochemical characterization of a pterin-specific adenylation domain RSC Chem. Biol. Pub Date : 2023-09-06 Stephanie C. Heard, Katharine L. Diehl, Jaclyn M. Winter
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Small molecules and conjugates as theranostic agents RSC Chem. Biol. Pub Date : 2023-09-02 Sumon Pratihar, Krithi K. Bhagavath, Thimmaiah Govindaraju
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Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1 RSC Chem. Biol. Pub Date : 2023-08-30 Kiall F. Suazo, Jakub Bělíček, Garrett L. Schey, Shelby A. Auger, Alexandru M. Petre, Ling Li, Katarzyna M. Błażewska, David Kopečný, Mark D. Distefano
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Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead RSC Chem. Biol. Pub Date : 2023-08-31 Radosław P. Nowak, Leah Ragosta, Fidel Huerta, Hu Liu, Scott B. Ficarro, Justin T. Cruite, Rebecca J. Metivier, Katherine A. Donovan, Jarrod A. Marto, Eric S. Fischer, Breanna L. Zerfas, Lyn H. Jones
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Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand RSC Chem. Biol. Pub Date : 2023-08-30 Yuliya Dantsu, Ying Zhang, Wen Zhang
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Metabolic labelling of DNA in cells by means of the “photoclick” reaction triggered by visible light RSC Chem. Biol. Pub Date : 2023-08-30 Lisa Rieger, Bastian Pfeuffer, Hans-Achim Wagenknecht