Rhotomentodiones C–E ( 1 ‒ 3 ), three new polymethylated phloroglucinol meroterpenoids with diverse configurations, were isolated from the twigs and leaves of Rhodomyrtus tomentosa . Their structures and absolute configurations were established mainly by means of comprehensive spectroscopic data and electron circular dichroism (ECD) calculation. Among them, compound 2 exhibited both antibacterial activity

Dyssodia decipiens is one of the seven recognized species within the Dyssodia genus which has economic and social relevance in Mexico. Herein we report on the volatile characterization and pharmacological activity of D. decipiens . The annual essential oils (2017‐2019) contained verbenone (30.8‐60.9%), limonene (5.6‐35.5%), β‐caryophyllene (7.8‐19.8%) and linalool (4.5‐12.4%) as major constituents

One new dihydrobenzofuran neolignan, patrinianeolignan I ( 1 ), two new monoterpenes, 6,7‐dehydrodissectol A ( 2 ) and patriniaol A ( 3 ), and a new γ ‐pyrone derivative, hydroxymaltol 3‐O‐(6'‐O‐ trans ‐caffeoyl)‐ β ‐D‐glucopyranoside ( 4 ), along with fifteen known lignans ( 5 ‐ 19 ), eight known monoterpenes ( 20‐27 ), and two known γ ‐pyrone derivatives ( 28 , 29 ), were isolated from the whole

The in vitro tissue culture of American ginseng has wide commercial applications in pharmaceutical, nutraceutical, food, and cosmetic fields with regard to the production of bioactive compounds such as ginsenosides and polysaccharides. This review highlights the recent progress made on different types of tissue culture practices with American ginseng, including callus culture, somatic embryo culture

Ligaria cuneifolia (Ruiz & Pav.) Tiegh (Loranthaceae), the “Argentine mistletoe”, is a hemiparasite species largely used in folk medicine. The aim of this study was to evaluate the antioxidant activity using in vitro, ex vivo, and in vivo methods. A screening of phenolics was performed by UV spectroscopy on different fractions. The antioxidant capacity was evaluated in vitro by the 1,1‐diphenyl‐2‐picrylhydrazyl

As a new woody oleaginous crop, tree peony is now being widely developed and utilized, which attributed to the outstanding oil‐use features regarding the fatty acid profiles and bioactivity. The major fatty acid profiles and bioactivity of seed oils in ten tree peony varieties collected from a common garden were investigated in the present study. The results showed that the oil yields, fatty acid profiles

Ten bromotyrosine alkaloids( 1 ‐ 10 ) were isolated and characterised from the marine sponge Aplysinella rhax ( de Laubenfels 1954) collected from the Fiji Islands, which included one new bromotyrosine analogue, psammaplin P ( 6 ) and two other analogues, psammaplins O ( 5 ) and 4‐bromo‐6‐carbomethoxy salicylic acid ( 7 ), which have not been previously reported from natural sources. HRESIMS, 1D and

Four xanthone derivatives were synthesized and evaluated as acetylcholinesterase inhibitors (AChEIs) with metal chelating ability and antioxidant ability against Alzheimer’s disease (AD). Most of them exhibited potential acetylcholinesterase (AChE), butylcholinesterase (BuChE) inhibitory, antioxidant and metal chelating properties. Among them, 3‐(2‐( pyrrolidinyl)ethoxy)‐1‐ hydroxy‐9H‐xanthen‐9‐one

In order to discover novel potential antifungal agents, a series of 6‐substituted n‐butyphthalide derivatives were designed, synthesized and evaluated for their antifungal activities against nine phytopathogenic fungi. Preliminary bioassay tests showed that compounds n‐butyphthalide, 3 , 4 , 6a , 7a and 7b exhibited more potent antifungal activities that hymexazol at the concentration of 50 μ g/mL

The chemical investigation on endophytic fungus Annulohypoxylon cf. stygium in leaves of Anoectochilus roxburghii (Wall.) Lindl. Sixteen compounds were isolated and their structures were identified as palmarumycin CP2 ( 1 ), (‐)‐(3R)‐mellein methyl ethe ( 2 ), kipukasins D ( 3 ), kipukasins E ( 4 ), secosterigmatocystin ( 5 ), notoamide D ( 6 ), notoamide C ( 7 ), (+)‐versicolamide B ( 8 ), (‐)‐notoamide

Spartina maritima and Puccinellia maritima are two fascinating but underexplored halophytic species, and herein is described their hexane extracts chemical profile. Terpenoids and sterols were the most abundant chemical group in both species. The second dominant class was alcohols and the third esters of fatty acids. The chemical lipophylic profile of both S. maritima and P. maritima is herein reported

An extensive phytochemical study of the aerial parts of Vernonia guineensis Benth. (Asteraceae) led to the isolation of a new flavone, vernoguinoflavone (1) and a naturally isolated glycerol ester, bisarachidicester (2), together with eighteen known secondary metabolites including quercetin (3), luteolin (4), vernopicrin (5), vernomelitensin (6), β‐amyrin (7), oleanolic acid (8), ursolic acid (9),

The present study was aimed at analyzing the chemical components of the essential oil from six Pyrrosia species by GC‐MS and evaluate their in vitro antibacterial activities. Seventy volatile compounds were identified in the essential oil of six Pyrrosia samples. The identified volatile components were divided into the following nine categories: aldehydes, terpenoids, fatty acids, ketone, furans, hydrocarbons

Semisynthetic functionalized triterpenes ( 1 , 3β‐acetoxy‐8a,9a‐epoxy‐4a,14a‐dimethyl‐5a‐cholestane; 2 , 4α,14α‐dimethyl‐5α‐cholest‐8‐ene‐3,7,11‐trione; 3 , 4α,14α‐dimethyl‐5α‐cholesta‐7,9‐dien‐3‐one and 4 , 3β‐acetoxy‐4a,14a‐dimethyl‐5a‐cholest‐8‐ene), previously prepared from 31‐norlanostenol, a natural insecticide isolated from Euphorbia officinarum latex, have been subjected to oxidation with hydrogen

The current study was carried out by a bioguided‐fractionation of a hexane extract of Euphorbia umbellata latex against leukemic cells. Samples were analyzed by NMR, GC‐MS, triterpenes quantification, and MTT reduction assay. Morphological, cell cycle, mitochondrial membrane potential and caspases 3/7 analyses were performed for the dichloromethane and ethanol fractions, and selectivity index for the

In the present study, coumarin‐bearing three pyridinium and three tetra‐alkyl ammonium salts were synthesized. The compounds were fully characterized by 1H and 13C NMR, LC‐MS and IR spectroscopic methods and elemental analyses. The cytotoxic properties of all compounds were tested against human liver cancer (HepG2), human colorectal cancer (Caco‐2) and non‐cancer mouse fibroblast (L‐929) cell lines

Resistance to chemotherapeutic drugs is a critical problem in cancer therapy, but the underlying mechanism has not been fully elucidated. TP53‐induced glycolysis regulatory phosphatase (TIGAR), an important glycolysis and apoptosis regulator, plays a crucial role in cancer cell survival by protecting cells against oxidative stress‐induced apoptosis. In the present study, we investigated whether TIGAR

Erodium cicutarium is known for its total polyphenolic content, but this work reveals the first highly detailed profile of E. cicutarium , obtained with UHPLC‐LTQ OrbiTrap MS 4 and UHPLC‐DAD MS/MS techniques. A total of 85 phenolic compounds were identified and 17 constituents quantified. Overall, 25 new compounds were found, which have not yet been reported for the Erodium genera, or the family Geraniaceae

We aimed to evaluate the bioherbicide potential of Eucalyptus saligna leaf litter essential oil, its fractions and major compounds. Six essential oil fractions were obtained by preparative thin‐layer chromatography and analyzed by gas chromatography/mass spectrometry. Effects of the oil, its fractions and major compounds (1,8‐cineole and/or α‐pinene) diluted in aqueous solution were assessed on germination

In this study, chemical composition and in vitro biological activities of artichoke by‐products (leaves, floral stems and bracts) issued from two Tunisian varieties were evaluated. Analysis was performed by means of high‐performance liquid chromatography with diode array detection coupled to electrospray ionisation mass spectrometric (LC/DAD/ESI‐MS). Total phenolic (TPC) and flavonoid (TFC) contents

The emodin anthraquinone derivatives are generally used in traditional Chinese medicine due to their various pharmacological activities. In the present study, a series of emodin anthraquinone derivatives have been designed and synthesized among which 1,3‐Dimethoxy‐6,8‐dihydroxy‐anthraquinone ( 11b ) is a natural compound that has been synthesized for the very first time, and 1,3‐Dimethoxy‐5,8‐dimethyl‐anthraquinone

The current research examined for radiolytic structure modification and improved bioefficacy of phloridzin by gamma‐ray, subsequent to a 50 kGy irradiation dose. Structures of the unusual degraded products phlorocyclin (2), isophlorocyclin (3), and radiophlorisin (4) were determined spectroscopically, by detailed nuclear magnetic resonance (NMR) and mass spectrometry (MS). Additionally, absolute stereochemistry

A variety of 1,4‐benzodiazepine azomethines (3a‐n) and 1,4‐benzodiazepine benzamide (4) were prepared, characterized and evaluated for the anticonvulsant activity in the rat using picrotoxin‐induced seizure model. The prepared 1,4‐benzodiazepine azomethine derivative emerged potentially anticonvulsant molecular scaffolds exemplified by compounds, 7‐(4‐nitrophenyl)methyleneamino‐5‐phenyl‐1,3‐dihydro‐1

A new decenoic acid derivative, gelliodesinic acid ( 1 ), and a natural new indole alkaloid ( 2 ), together with three known furanoterpenoids ( 3 − 5 ) and two known indole alkaloids ( 6 − 7 ), were isolated from the MeOH extract of the marine sponge Gelliodes sp. collected in Vietnam. The chemical structures of 1 − 7 were determined by analyses of 1D‐ and 2D‐NMR and MS data and by comparisons of the

A series of aryloxyacetamine derivatives W1 ‐ W37 were designed, synthesized and evaluated for their biological activity. Their structures were confirmed by 1 H‐NMR, 13 C‐NMR, and HR‐ESI‐MS. The preliminary screening of neuroprotection of compounds in vitro was detected by MTT, and the anti‐ischaemic activity in vivo was tested using bilateral common carotid artery occlusion in Kunming Mice. Most of

The chemotherapy of schistosomiasis remains centered in the use of praziquantel. However, there has been growing resistant parasites to this drug. Thus, the aim of this work was to evaluate in vitro schistosomicidal activity of the hexanes‐dichloromethane 1:1 extract of Brazilian green propolis (Pex), as well as its major isolated compounds artepillin C ( 1 ), caffeic acid ( 2 ), coumaric acid ( 3

Ginseng and Ziziphi Spinosae Semen, which are traditional Chinese medicinal materials, were often used in ancient Chinese recipes as a pair of medicines. They can replenish the primordial qi and tonify the spleen. This study investigated the effects of ginseng and Ziziphi Spinosae Semen ( GS ) extract on gut microbiota diversity in rats with spleen deficiency syndrome ( SDS ). A total of 52 compounds