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Front Cover: Exploring Culture Media Diversity to Produce Fungal Secondary Metabolites and Cyborg Cells (Chem. Biodiversity 3/2024) Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-15 Regina Geris, Vitória Evelyn Teles de Jesus, Antonio Ferreira da Silva, Marcos Malta
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Contribution of Phenolic Compounds to the Antioxidant Activity of Leaf and Flower Extracts of Sinapis pubescens L. subsp. pubescens (Brassicaceae) Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-16 Maria Fernanda Taviano, Paola Arena, Federica Davì, Emilia Cavò, Vivienne Spadaro, Francesco Maria Raimondo, Francesco Cacciola, Roberto Laganà Vinci, Luigi Mondello, Natalizia Miceli
Within a study focused on Sinapis pubescens subsp. pubescens wild from Sicily (Italy), an edible species still unexplored, our earlier published work has demonstrated good in vitro antioxidant properties for the flower and leaf hydroalcoholic extracts, exhibiting quite different qualitative‐quantitative phenolic profiles. Herein, further research was designed to elucidate the role played by phenolic
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A NEW RARE HALOGENATED DEPSIDE FROM LICHEN AND STUDY OF ITS ANTI‐PROLIFERATIVE ACTIVITY Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-16 Ajoy Kumar Bauri, Carcache Carcache de Blanco, Ines Yolanda Castro-Dionicio, Eric Salinas Arellano, Jonathan G Jeyaraj, Sabine Foro
Lichens are (Permotrema parlatum) a symbiotic association of algae and fungus belonging to the family Parmeliaceae. Some of lichen species are consumable and used as an active ingredient for preparation exotic spices as well as folklore medicine to cure different kind of ailments. A specimen of lichen was collected from Munner in Kerala State of South India for its chemical profiling. Chemical analyses
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Ephedra intermedia Schrenk & C. A. Mey Methanol Extract: Nanoencapsulation by Mini‐Emulsion Polymerization and its Release Trend under Simulated Conditions of the Human Body Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-16 Behnam Mahdavi, Sanaz Ebrahim, Gholam Ali Farzi, Behroz Maleki, Majid Mohammadhosseini
In this research, the extract of Ephedra intermedia Schrenk &C.A.Mey was encapsulated using the mini‐emulsion polymerization method based on methyl methacrylate polymers with a nanometer size. The encapsulated extract was characterized using different analytical techniques. Furthermore, the loading efficiency and release of the plant extract were examined. FT‐IT spectroscopy confirmed the formation
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Design, synthesis, biological evaluation and in silico studies of curcumin pyrrole conjugates Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-16 Nishi Gandha Gogoi, Aziza Rahman, Pankaj Dutta, Jiban Saikia, Anupaul Baruah, Jyotirekha G Handique
Curcumin conjugated heterocyclic compounds are potent candidates with drug likeness against various bacterial pathogens. A set of curcumin‐based pyrrole conjugates (CPs) were synthesized and characterized by FT‐IR, 1H and 13C NMR and HR‐MS techniques. The results free radical scavenging activity of the synthesized CPs, evaluated by FRAP and CUPRAC assays, showed the potency of these compounds as effective
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New analogues of amides and quinolinones produced by Streptomyces sp. YIM S01983 Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-16 Xia Li, Dou-Ying Zhu, Xi-Ru Liu, Hong-Jian Liu, Shu-Kun Tang, Le Cai, Li-Xing ZHAO
Streptomide (1), a new amide analogue, streptomynone (2), a new quinolinone, and ten known compounds including three aliphatic acids (3‐5), two amides (6‐7), four cyclic dipeptides (8‐11), and an adenosine (12) were also obtained from the fermentation broth of a Streptomyces isolate collected from a sediment sample of soil sample collected in Bendong Village, Huadong Town, Chuxiong, China. Their structures
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Bibenzyl‐phenylpropane Hybrids with Immunosuppressive Activities from Dendrobium nobile Lindl. Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-15 Qing-Tao Wang, Chao-Fan Wang, Ying Liu, Rui Zhan
Fifteen bibenyls and four fluorenones, including five new bibenzyl‐phenylpropane hybrids, were isolated from the aerial part of Dendrobium nobile Lindl. Their structures were determined by spectroscopic methods. Bioassay on the LPS‐induced proliferations of mouse splenic B lymphocytes, and Con A‐induced T lymphocytes showed that compounds 1, 2, and 14 showed excellent immunosuppressive activities with
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PHYTOCHEMICAL PROFILING AND ASSESSMENT OF ANTIDIABETIC ACTIVITY OF CURCUMA ANGUSTIFOLIA RHIZOME METHANOLIC EXTRACT: AN IN VITRO AND IN SILICO ANALYSIS Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-14 Kavya P, Gayathri M
Curcuma angustifolia Roxb. is a plant with medicinal potential, traditionally used to treat different diseases. The present study was aimed to determine the antidiabetic activity of C. angustifolia rhizome in vitro and in silico. The methanolic extract of C. angustifolia rhizome was analysed by FTIR and GC‐MS to determine the phytochemicals present. The antidiabetic potential of the extract was evaluated
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Nutritional Composition and Therapeutic Potential of Pineapple Peel ‐ A Comprehensive Review Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-14 Arshad Farid, Mahrukh Mehraj, Susmita Das, Fathima Feroz, Ab Waheed Wani, S.Q Dar, Sanjeev Kumar, Atif Khurshid Wani
Pineapple (Ananas comosus), the succulent and vibrant tropical fruit, is a symbol of exoticism and sweetness. The pineapple peel, often considered as waste, has garnered attention for its potential applications. The pineapple peel is rich in essential nutrients, including calcium, potassium, vitamin C, carbohydrates, dietary fiber, and water, making it beneficial for the digestive system, weight management
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SYNTHESIS, THEORETICAL STUDY, AND ANTICONVULSANT EVALUATION OF N‐ARYLENAMINONES Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-13 Hugo A. Jiménez-Vázquez, J. Alberto Guevara-Salazar, Delia Quintana-Zavala
N‐Arylenaminones are highly versatile compounds which can be synthesized in relatively simple ways. In this work we explored the synthesis of the four monosubstituted N‐(4‐R‐phenyl)enaminones 3a (R = NO2), 3b (R = F), 3c (R = H), and 3d (R = OMe) with the goal of determining the influence of the substituents' electronic effects on tautomer stability and biological activity. These compounds were analyzed
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Facile and Novel Synthetic Approach, Molecular docking, Molecular dynamics, and Drug‐Likeness Evaluation of 9‐substituted Acridine Congeners as Dual Anticancer and Antimicrobial Agents Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-13 Mohamed Aboelenien, Mahmoud Basseem I. Mohamed, Mohamed M. Elsenety, Ahmed A. El-Rashedy, Samirah H. Ghalib, Fatima Abdelgalil E. Mohamed, Nora M. A. El-Ebiary, Abeer A. Ageeli
In the present study, numerous acridine congeners A1‐A20 were synthesized via aromatic nucleophilic substitution (SNAr) reaction of 9‐chloroacridine with carbonyl hydrazides, amines, or phenolic derivatives depending upon facile, novel, and eco‐friendly approaches (Microwave and ultrasonication assisted synthesis). The newly compounds’ structures were explicated utilizing spectroscopic methods. The
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Investigating the effects and mechanisms of cyclomorusin on osteoclasts in a high glucose environment Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-13 Donggui Guo, Jun Zhu, Hui-juan Wang, Bo-Wen Pan
Diabetes mellitus is an endocrine disease characterized by prolonged hyperglycemia. Prolonged high blood sugar levels interfere with the differentiation and maturation process of osteoblasts and osteoclasts, leading to the onset of osteoporosis. However, osteoclast differentiation and maturation is a complex regulatory process. This study investigated the impact of high glucose concentrations on the
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Evaluation of the Antiproliferative Potential of yellow Jaboticaba (Myrciaria glazioviana) extracts against Human Cervical Cancer (HeLa cells line) and the Analysis of their Chemical Composition by HPLC‐HRESIMS Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-12 Mariana Toledo Martins Pereira, Thiago Sardou Charret, Guilherme Freimann Wermelinger, Thalya Soares Ribeiro Nogueira, Bruno Kaufmann Robbs, Raquel Carvalho Castiglione, Rafael L. Simões, Ricardo Luiz Dantas Machado, Ivo José Curcino Vieira, Lucas Silva Abreu, Vinicius Davila Bitencourt Pascoal, Aislan Cristina Rheder Rheder Pascoal
There is a high demand for new effective antineoplastic drugs with few side effects. In this sense, recent research highlights the potential of compounds of natural origin in treating and preventing different types of cancer. This study aims to evaluate the anticancer activity of the dichloromethane extract (MGD) and ethyl acetate extract (MGA) of Myrciaria glazioviana leaves against human cervical
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Sesquiterpene Acids and Lactones from Inula Confertiflora with Their Antibacterial Activities Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-12 Bonsa Hussein Ahmed, Mekonnen Abebayehu Desta, Ashenafi Alemu Wami, Getachew Tesfaye Beyene, Kibrom Gebreheiwot Bedane
The phytochemical investigation of the leaves of Inula confertiflora, a medicinal plant endemic to Ethiopia, led to the isolation of 15 terpenoids; 1β‐hydroxy‐α‐costic acid (1), 3α‐hydroxycostic acid (2), isotelekin (3), asperilin (4), carabrone (5), carpesioline (6), graveolide (7), inuviscolide (8), 8‐epi‐inuviscolide (9), 1β,4β‐dihydroxy‐5α(H)‐guaia‐10(14),11(13)‐dien‐8α,12‐olide (10), isoinuviscolide
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In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p‐Coumaric Acid Prenylated Derivatives Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-12 Tatiana M. Vieira, Júlia G. Barco, Lucas A. L. Paula, Paulo C. A. Felix, Jairo K. Bastos, Lizandra G. Magalhães, Antonio Crotti
We have evaluated eight p‐coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)‐3,4‐diprenyl‐4‐isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC50 = 45.92 µM) and S. mansoni (IC50 = 64.25 µM). Data indicated that
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Palladium(II) Complexes of 4‐Phenyl‐3‐thiosemicarbazone Ligands: Insights Into Cytotoxic Properties And Mode of Cell Death Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-12 Ahmed Mansour, Rabaa M. Khaled, Krzysztof Radacki, Ola R Shehab, Gamal A. E. Mostafa, Essam A. Ali, Mahmoud T. Abo-Elfadl
Reactions between sodium tetrachloropalladate and 2‐ (or 4‐) substituted 4‐phenyl‐3‐thiosemicarbazone ligands (HLR), with various electron‐donating and electron‐withdrawing substituents (R = OCH3, NO2, and Cl), afford square‐planar complexes of the general formula [Pd(LR)2]. Ground‐state geometry optimization and the vibrational analysis of cis‐ and trans‐isomers of the complexes were carried out to
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REVERSAL OF VALPROATE‐INDUCED MAJOR SALIVARY GLAND CHANGES BY MORINGA OLEIFERA EXTRACT IN RATS Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-12 Eda Cergel, Burcin Alev Tuzuner, Ismet Burcu Turkyilmaz, Sehkar Oktay, Umar Faruk Magaji, Ozlem Sacan, Refiye Yanardag, Aysen Yarat
This study aimed to explore the potential protective impacts of Moringa oleifera extract on major alteration in salivary glands of rats exposed to sodium valproate (VA). Groups were defined as control, control + moringa extract, sodium valproate, and sodium valproate + moringa extract. Antioxidant and oxidant status, activities of digestive and metabolic enzymes were examined. VA treatment led to various
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Inhibitory Activity in Vitro against Rhizoctonia solaniand Chemical Composition of Petroleum Ether Extract from Moutan Cortex Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-12 Yongtian Zhao, Xinge Wang, Xin Han, Aixia Ren, Xiaona Huang, Shaungyan Fang, Hongting Chen, Lian Zhang
Rice sheath blight (RSB), caused by Rhizoctonia solani, is a significant disease of rice. The negative effects of chemical fungicides have created an urgent need for low‐toxicity botanical fungicides. Our previous research revealed that the ethanol crude extract of Moutan Cortex (MC) exhibited superior antifungal activity against R. solani at 1000 μg/mL, resulting in 100% inhibition rate. And the antifungal
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SYNTHESIS OF SOME NOVEL THIOPHENE ANALOGUES AS POTENTIAL ANTICANCER AGENTS Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-12 Altaf S. Almatari, Ali Saeed, Ghada E. Abdel-Ghani, Mahmood M.S. Abdullah, Hamad A. Al-Lohedan, Ehab Abdel-Latif, Amr El-Demerdash
The aim of this study involves the synthesis novel thiophene analogues that can be used as anticancer medications through a strategic multicomponent reaction connecting ethyl 4‐chloroacetoacetate (1), phenyl isothiocyanate, and a series of active methylene reagents, including ethyl acetoacetate (2), malononitrile, ethyl cyanoacetate, cyanoacetamide 6a‐c, N‐phenyl cyanoacetamide derivatives 13a‐c, and
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Preparation of the Myricetin‐Loaded PEGylated Niosomes and Evaluation of their in vitro Anti‐Cancer Potentials Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-12 Hanieh Riazi, Mohammad Taghi Goodarzi, Masoud Homayouni Tabrizi, Majid Mozaffari, Ali Neamati
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Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-11 Tarık Aanniz, Nasreddine El Omari, Youssef El Ouafy, Taoufiq Benali, Gokhan Zengin, Asaad Khalid, Ashraf N. Abdalla, Ashraf M. Sakran, Abdelhakim bouyahya
Encapsulation has emerged as a vitally important tool for protecting the integrity of critical chemicals and improving the delivery mechanisms of natural/synthetic drugs, enabling the controlled release of ingredients and the maintenance of their chemical, physical, and biological properties. It is well known that essential oils (EOs) provide a valuable alternative for food preservation, as they help
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Design and Synthesis of 2‐Phenylindolizine Acetamides: Molecular Docking, in Vitro Antimicrobial and Anticancer Activity Evaluation Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-11 Siva Kumar Gandham, Anjali Jha, Amit A. Kudale
In the present work, we synthesized a small library of 2‐phenylindolizine acetamide derivatives 7a‐i and studied their biological activity. The synthesis was accomplished starting with easily available starting material phenacyl bromide 1 proceeding through the key intermediate 6‐methyl‐7‐nitro‐2‐phenylindolizine 4. All the compounds 7a‐i were characterized using spectroscopy viz., 1H NMR, 13C NMR
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Exploring the Diverse Biological Properties of Cannabidiol: A Focus on Plant Growth Stimulation Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-11 Daniela Gruľová, Beáta Baranová, Rosaria Francolino, Hazem Elshafie, Zuzana Kiššová, Alžbeta Glovaťáková, Laura De Martino, Giuseppe Amato, Mara Martino, Lucia Caputo, Flavio Polito, Francesco Manna, Ippolito Camele, Ľudmila Tkáčiková, Vincenzo De Feo
The aim of the current study was to compare some biological activities of edible oils enriched with 10% of cannabidiol (CBD samples) from the Slovak market. In addition, hemp, coconut, argan, and pumpkin pure oils were also examined. The study evaluated the fatty acids content, as well as antibacterial, antifungal, antioxidant, cytotoxic, and phytotoxic activities. The CBD samples presented antimicrobial
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Synthesis, Antimicrobial Evaluation, DFT, and Molecular Docking Studies of Pyrano[4,3‐b]Pyranone and Pyrano[2,3‐b]Pyridinone Systems Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-11 wafaa hamama, Eslam A. Ghaith, Hanafi H. Zoorob
SDehydroacetic acid (DHA) was utilized as a fundamental precursor in the synthesis of novel pyrano[4,3‐b]pyran and pyrano[2,3‐b]pyridine systems. Whereas, a new series of fused polyheteronuclear systems was achieved through the reaction of DHA with active methylene compounds such as malononitrile and pyrazolone. Whereas, the treatment of DHA 1 with cyclic ketones involving cyclohexanone and cyclododecanone
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Curcumae Radix: A Review of Traditional Use, Phytochemistry, Pharmacology, Toxicology and Quality Control Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-11 Yu-Ting Niu, Hao-Nan Xu, Yu-Ying Zhang, Xin-Zhuo Li, Yu-Ze Li, Xiao-Mei Song, Dongdong Zhang, Wei Wang
Curcumae Radix (CuR) is a traditional Chinese medicine that has been used in China for more than 1,000 years. It has the traditional efficacy of activating blood and relieving pain, promoting qi and relieving depression, clearing heart and cooling blood, and promoting gallbladder and removing jaundice. Based on this, many domestic and foreign scholars have conducted systematic studies on its chemical
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In Silico and In Vitro Screening of Some Pregnane Glycosides Isolated from Certain Caralluma Species as SARS‐COV‐2 Main Protease Inhibitors Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-11 Essam Abdel‐Sattar, Omnia Kutkat, Riham A. El‐Shiekh, Mohamed K. El‐Ashrey, Ahmed M. El Kerdawy
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Antioxidant, antimicrobial and Molecular Docking studies of new Isolated /Spiro β‐ Lactam and thiazolidinone derivatives bearing 1,8‐naphthyridine moiety Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-09 Nadia Elkanzi, Hajer Hirichi, Alaa Alsirhania, Rania Baker
A series of spiro β‐ Lactams (4a‐c, 7a‐c) and thiazolidinones (5a‐c, 8a‐c) possessing 1,8‐naphthyridine moiety were synthesized in this study. The structure of the newly synthesized compounds has been confirmed by IR, 1H NMR, 13C NMR mass spectra, and elemental analysis. The synthesized compounds were tested in vitro for their antibacterial and antifungal activity against various strains. The antimicrobial
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α‐Glucosidase Inhibitory Components from Garcinia pedunculata Fruits Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-09 Deli Zou, Lei Liu, Fangshen Liu, Dahong Li, Huiming Hua
: From Garcinia pedunculata Roxb. fruits, two undescribed aromatic compounds including a benzofuran and a depsidone derivative, and a new natural product, together with four known compounds were isolated. Through the analysis of spectroscopic data, high resolution mass spectrum and calculated nuclear magnetic resonance, their structures were determined. The α‐glucosidase inhibitory activity of the
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Exploring the Anti‐Cancer Potential of Hispidin: A Comprehensive In Silico and In Vitro Study on Human Osteosarcoma Saos2 Cells Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-08 Khedidja Benarous, Arif Mermer, Talia Serseg, Aydin Tahmasebifar, Houssem Boulebd, Abderahmane Linani
Hispidin was initially discovered in basidiomycete Inonotus hispidus (Bull.) P. Karst and this extraordinary compound possesses immense potency and can be extracted from the wild mushroom through specialized bioreactor cultivation techniques. In our study, we isolated it from Inonotus hispidus (Bull.) P. Karst., with a yield of 3.6%. We identified and characterized hispidin through the implementation
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Design, Synthesis and In vitro Antitubercular Effect of New Chalcone Derivatives Coupled with 1,2,3‐Triazoles: A Computational Docking Techniques Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-08 Kumaraswamy Sadineni, Sravanthi Reddy Basireddy, Tejeswara Rao Allaka, Satyanarayana Yatam, Srinu Bhoomandla, Venkatanaryana Muvvala, Sharath Babu Haridasyam
A very interesting foundation for this study is the creation of new methods for modifying compounds with a 1,2,3‒triazole and chalcones, as these compounds are significant in organic synthesis as bioactive organic compounds. To contribute to the development of an efficient method for the conversion of antimicrobial and anti‐TB drugs, a novel series of cyclohepta pyridinone fused 1,2,3–triazolyl chalcones
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Antiplatelet and Anticoagulant Effects of Two New Phenylpropanoid Sucrose Esters and Other Secondary Metabolites from the Aerial Part of Canna edulis Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-08 Thi Van Anh Nguyen, Thi Minh Hang Nguyen, Thi Thoa Ha, Thuy Duong Nguyen, Duc Huy Bui
This study isolated pure compounds from Canna edulis aerial parts and assessed their antiplatelet and anticoagulant potential. Structural elucidation resulted in the identification of two new compounds: caneduloside A (1) and caneduloside B (2), and eleven known compounds: 6’‐acetyl‐3,6,2’‐tri‐p‐coumaroyl sucrose (3), 6¢‐acetyl‐3,6,2¢‐triferuloyl sucrose (4), tiliroside (5), afzelin (6), quercitrin
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Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus with Embryotoxicity Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-08 Yanfang Liu, Zhen Lu, Zhi Yan, Xiaodong Li, Xiuli Yin, Ranran Zhang, Yaxi Li, Song Wang, Xie Ruliang, Ke Li
Sea cucumbers release chemical repellents from their guts when they are in danger from predators or a hostile environment. To investigate the chemical structure of the repellent, we collected and chemically analyzed the viscera of stressed sea cucumbers (Apostichopus japonicus) in the Yellow Sea of China. Two undescribed triterpene glycosides (1 and 2), together with a known cladoloside A (3), were
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Design, synthesis and antifungal activity of nootkatone derivatives containing acylhydrazone and oxime ester Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-08 Liang QiLong, Gao FuTian, Jian JunYou, Yang Jue, Lie-Jun Huang, Hao Xiaojiang
In an attempt to search for new natural products‐based antifungal agents, fifty‐three nootkatone derivatives were designed, synthesized, and evaluated for their antifungal activity against Phytophthora parasitica var nicotianae, Fusarium oxysporum, Fusarium graminearum and Phomopsis sp. by the mycelium growth rate method. Nootkatone derivatives N17 exhibited good inhibitory activity against Phomopsis
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Chemical Constituents from the Heartwood of Solanum Verbascifolium L.And Their Anti‐Inflammatory Activities Combined Network Pharmacology Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-08 Jin-Na Zhao, Shu-Fei Yu, Zhi-Hang Wu, Lu Chen, Rong Fu, Ze Li, Yan-Liang Qu, Jian Huang, Libo Wang, Xian-Mei Piao, Jin-Hui Wang
Phytochemical studies on 95% ethanol extract of the heartwood of Solanum verbascifolium L. resulted in the isolation of one new amide derivative (1), and 21 known phenylpropanoids compounds. The structures were characterized by spectral analysis and high‐resolution mass spectrometric analysis. The anti‐inflammatory activity of amide compounds 1‐4 and 6‐9 by investigating their impact on the release
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Stable Isotope Tracer Technique and Network Pharmacology to Reveal Antidepressant Targets and Active Components of Xiaoyao San Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-07 Junsheng Tian, xianxian wang, Wenze Wu, Yunhao Zhao, Ting Ling-hu, Xuemei Qin
In recent years, the research of mitochondrial dysfunction in depression has drawn the focus of researchers. Our research group previously found that Xiaoyao San (XYS) has improved the mitochondrial structure and the blocked tricarboxylic acid cycle (TCA cycle) in the hippocampal tissue of chronic unpredictable mild stress (CUMS) rats. However, the specific targets and active components of XYS remain
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Potential Hepatprrotective Effect of Matricaria Pubescens on High‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Rats Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-07 Chenna Houssem, Khelef Yahia, Halimi Imen, Yilmaz Mustafa Abdullah, Çakir Oğuz, Djouder Chaouki, Tarhan Abbas, Idoughi Khouloud, Boumendjel Mahieddine, Boumendjel Amel, Messarah Mahfoud
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Discovery of 6‐Acylamino/Sulfonamido Benzoxazolone with IL‐6 Inhibitory Activity as Promising Therapeutic Agents for Ulcerative Colitis Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-06 Re Ge, Jiaqi Song, Zhen Cao, Shurong Ban, Li Tang, Qingshan Li
Ulcerative colitis has been widely concerned for its persistent upward trend and sustained overproduction of pro‐inflammatory cytokines such as IL‐6 remains a crucial factor in UC development. Therefore, identification of new effective drugs to block inflammatory responses is an urgent and viable strategy for UC. In our research, twenty‐three 6‐acylamino/sulfonamido benzoxazolone derivatives were synthesized
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Four New Isocoumarins from the Mangrove Fungus Alternaria malorum with antimicrobial activities Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-06 Wei Fan, Yiwen Tao, Canmin Jiang, Qisen Huang, Jiacong Li, Weijia Ding, Chunyuan Li
Four new isocoumarins, alternariethers A‐C (1‐3) and alternariester (4) were separated from the fermentation of the fungus Alternaria malorum FL39, purified from Myoporum bontioides. Their structures were ascertained using NMR and HR‐ESI‐MS spectroscopy. For compound 4, the absolute configuration was solved with the help of ECD calculation and the DP4+ method. Compared with the positive control triadimefon
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Synthesis, Structural Characterization, and Biological Activities of 1,3,4‐ thiadiazole Derivatives Containing sulfonylpiperazine structures Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-05 You-hua Liu, Fa-li Wang, Xiao-li Ren, Chang-kun Li, Lin-hong Jin, Xia Zhou
To develop novel bacterial biofilm inhibiting agents, a series of 1,3,4‐thiadiazole derivatives containing sulfonylpiperazine structures were designed, synthesized, and characterized using 1H nuclear magnetic resonance (1H NMR), 13C nuclear magnetic resonance (13C NMR), and high‐resolution mass spectrometry. Meanwhile, their biological activities were evaluated, and the ensuing structure–activity relationships
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Bioactivities and action mechanisms of ellipticine derivatives reported prior to 2023 Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-04 Wen Hou, Xin-Liang Xu, Le-Jun Huang, Zhen Yu Zhang, Zhi-Nuo Zhou, Jin-Yang Wang, Xi Ouyang, Su-Ya Xin, Zi-Yun Zhang, Yi Xiong, Hao Huang, Jin-Xia Lan
Currently, natural products are one of the priceless options for finding novel chemical pharmaceutical entities. Ellipticine is a naturally occurring alkaloid isolated from the leaves of Ochrosia elliptica Labill. Ellipticine and its derivatives are characterized by multiple biological activities. The purpose of this review was to provide a critical and systematic assessment of ellipticine and its
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Aloe juvenna Brandham & S.Carter as α‐Amylase Inhibitor and Hypoglycaemic Agent with Anti‐inflammatory Properties for Diabetes Management. Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-04 Mona Raslan, Iman A.A. Kassem, Neveen S. Ghaly, May A. El-Manawaty, Farouk Rasmy Melek, Marian Nabil
Despite Aloe’s traditional use, Aloe juvenna Brandham & S.Carter is poorly characterized. Other Aloes are known for their antidiabetic activity. This study describes the antidiabetic potentials and phytoconstituents of the A. juvenna leaves methanolic extract (AJME). Twenty‐six phytoconstituents of AJME were described using HPLC/MS‐MS. Lupeol and vitexin were isolated using column chromatography. The
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Effects of naphthoquinones from the roots of Onosma armeniacum Klokov on wound healing Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-04 Esra Akkol, Tuğba Subaş, Ufuk Özgen, Ipek Süntar, Mert Ilhan, Hikmet Keleş
In Turkish folk medicine, the roots of Onosmaarmeniacum Klokov are used to heal wounds, burns, hemorrhoids, hoarseness, dyspnea, stomach ulcers, and abdominal aches. The objective was to evaluate the plant's ethnopharmacological applications using in vivo pharmacological experimental models. In vivo linear incision and circular excision the wound models were used to assess the wound healing activity
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Flavonoid Compounds in Hippophae rhamnoides L. Protect Endothelial Cells from Oxidative Damage Through the PI3K/AKT‐eNOS Pathway Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-02 Mengyuan Wang, Xingfang Zhang, Zonghao Zhang, Li Tong, Song Yu, Yue Liu, Fang Yang
Sea buckthorn, a traditional medicinal plant, has been used for several years in China for the prevention and treatment of various diseases, a practice closely associated with its significant antioxidant activity. The aim of this study was to investigate the protective effects of sea buckthorn flavonoids on vascular endothelial cells in an oxidative stress environment. We isolated and extracted active
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Topical antiedematogenic activity of the essential oil of Psidium brownianum Mart. (OEPB) in murine ear edema models Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-02 Renata de Souza Sampaio, Anita Oliveira Brito Pereira Bezerra Martins, Lucas Yure, Renata Torres Pessoa, Jaime Ribeiro-Filho, Cícero Francisco Bezerra Felipe, Gyllyandeson de Araújo Delmondes, IRWIN ROSE ALENCAR MENEZES, Marta Regina Kerntopf
Psidium brownianum Mart is reported in the literature by antinociceptive and antioxidant activities, indicating that this species' secondary metabolites might be used to control inflammatory processes. The present study aimed to characterize the topical antiedematogenic activity of the essential oil of Psidium brownianum Mart. (OEPB) in ear edema models by different inflammatory agents. Female Swiss
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Synthesis of Indole-Linked Thiadiazoles and their Anticancer Action against Triple-Negative Breast Cancer Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-01 Renu Gavadia, Jyoti Rasgania, Neetu Sahu, Surendra Nimesh, Lacy Loveleen, Satbir Mor, Komal Jakhar
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BORAGO OFFICINALIS L.: A REVIEW ON EXTRACTION, PHYTOCHEMICAL, AND PHARMACOLOGICAL ACTIVITIES Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-01 SLOUGUI Nabila, Meriem SLAMA, Akila BENAISSA, Amine NEKKAA, Feriel SELLAM, Laetitia CANABADY-ROCHELLE
Borago officinalis L., an annual herb belonging to the Boraginaceae family, is used in the traditional medical practices of various countries and for multiple treatments, including respiratory disorders, colds, influenza, diarrhea, cramps, inflammation, palpitation, hypertension menopause, and post‐menopausal symptoms. Its pharmacological properties and biological activities ‐ among them antioxidant
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Occurrence and Biological Activities of Seco-Iridoids from Jasminum L. Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-01 Claudio Frezza, Roberta Maria Nicolosi, Elisa Brasili, Francesco Mura, Daniela De Vita
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Chemical Constituents of Ajuga lupulina and Their Anti‐ferroptosis ActivityChemical Constituents of Ajuga lupulina and Their Anti‐ferroptosis Activity Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-01 Xifeng Teng, Huiwen Shi, Liudan Cao, Xing Peng, Lin He, Qiong Gu
Five new compounds (1, 2, 7, 12, and 16), along with fifteen known ones, were isolated from Ajuga lupulina Maxim. Their structures were elucidated by spectroscopic data (MS, NMR) analysis, and the absolute configuration was determined by the experimental and calculated ECD spectra. Compound 16, with eight carbon atoms, was firstly isolated from the nature. All the isolates were assayed for their anti‐ferroptosis
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Discovery of Novel Hybrids of Edaravone and 6‐phenyl‐4,5‐ dihydropyridazin‐3(2H)‐one with Antiplatelet Aggregation and Neuroprotection for Ischemic Stroke Treatment Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-01 Yi Li, Jieying He, Bilan Luo Li, Qingyang Yu, Ting Cai, Yong Li, Lingling Fan, Xunrong Zhou, Lei Tang
Drugs with anti‐platelet aggregation and neuroprotection are of great significance for the treatment of ischemic stroke. A series of edaravone and 6‐phenyl‐4,5‐dihydropyridazin‐3(2H)‐one hybrids were designed and synthesized. Among them, 6g showed the most effective cytoprotective effect against oxygen–glucose deprivation/reoxygenation‐induced damage in BV2 cells and an excellent inhibitory effect
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GC-MS-based Metabolomics Unravels Metabolites across Larval Development and Diapause of a Specialist Insect Chem. Biodivers. (IF 2.9) Pub Date : 2024-03-01 Marília Elias Gallon, Eduardo Afonso Silva-Junior, Leonardo Gobbo-Neto
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Antioxidant, Cytotoxic, Anti-Glycation, and Anti-Tyrosinase Compounds from the Leaves of Uvaria Siamensis Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-29 Eakkaluk Wongwad, Supachai Jadsadajerm, Lapatrada Mungmai, Awat Wisetsai
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Synthesis and Antimicrobial Activity Evaluation of Pyridine Derivatives Containing Imidazo[2,1-b][1,3,4]Thiadiazole Moiety Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-29 Liu Yang, Yu-Xin Jiao, Yan-Hua Quan, Ming-Yu Li, Xin-Yi Huang, Jun-Zheng Jin, Siqi Li, Ji-Shan Quan, Cheng-Hua Jin
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New 1H‐1,2,4‐triazolyl derivatives as antimicrobial agents. Synthesis, biological evaluation and molecular docking Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-29 Athina Athanasios Geronikaki, Natalia Sucman, Eugenia Stingaci, Lucian Lupascu, Anastasia Smetanscaia, Vladimir Valica, Livia Uncu, Sergiu Shova, Anthi Petrou, Jasmina Glamočlija, Marina Sockovic, Fliur Macaev
Thirteen new 1H‐1,2,4‐triazolyl derivatives were synthesized, and six of them were selected based on docking prediction for the investigation of their antimicrobial activity against five bacterial and eight fungal strains. All compounds demonstrated antibacterial activity with MIC lower than that of the ampicillin and chloramphenicol. In general, the most sensitive bacteria appeared to be P.fluorescens
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Lachnuoic acids A–F: Ambuic Acid Congeners From A Saprotrophic Lachnum SpeciesLachnuoic acids A–F: Ambuic Acid Congeners From A Saprotrophic Lachnum Species Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-29 Kunthida Phutthacharoen, Rita Toshe, Syeda Javariya Khalid, Natalia A. Llanos-López, Jan-Peer Wennrich, Hedda Schrey, Sherif S. Ebada, Kevin D. Hyde, Marc Stadler
Chemical prospection of an extract derived from a saprotrophic fungus Lachnum sp. IW157 resulted in the isolation and characterization of six unprecedentedly reported ambuic acid analogues named lachnuoic acids A–F (1–6). Chemical structures of 1–6 were determined based on comprehensive 1D and 2D NMR spectroscopic analyses together with HR‐ESI‐MS spectrometry. The relative configurations of 1–3 were
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Structure and Synthesis of Vindolicine and Derivatives Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-26 Asia, Yousuf Sammer, Laure Vendier, Georges Massiot
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Lycopodium alkaloids from Huperzia goebelii Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-28 Bei-Bei Gao, Shuai Jiang, Wen-Yan Li, Yu-Fei Ou, Qin-Shi Zhao
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Two new isospirostanol‐type saponins derived from the bulbs of Lilium brownii and their anti‐hepatocarcinogenic activity Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-28 Shuaibo He, Tingjuan Wu, Yanpo Si, Jihong Kang, Wenjun Wei, Fei Zhang, Shuying Feng, Jianping Ma, Ya Wang, Tao guo
Bulbs ofLilium brownii, commonly known as "Bai‐he" in China, serve both edible and medicinal purposes in clinical practice. In this study, two new isospirostanol‐type saponins were isolated from L. brownii, and their structures were identified by spectroscopic method, and absolute configurations were elucidated by comprehensive analysis of spectral data obtained from combined acid hydrolysis. Two compounds
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Variability of Isoquinoline Alkaloid Profiles and Anticholinesterase Activities with Binding-Mode Predictions of Glaucium flavum Population Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-28 Buket Bozkurt, Duygu Ulkar, Necati Nurlu, Gunes Coban, Zinar Pinar Gumus, Nehir Unver-Somer
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Inhibitory Effects of Endemic Thyme’s Thymol‐Carvacrol Chemotype Essential Oil On Aspergillus Species with Free Radical Scavenging Properties Chem. Biodivers. (IF 2.9) Pub Date : 2024-02-28 Seyed Fazel Mirahmadi, Alireza Shayganfar
The study focused on utilizing the anti‐fungal and antioxidant properties of essential oils from Thymus daenensis Celak. subsp. daenensis to combat the growth of mycotoxin‐producing Aspergillus species, including A. flavus, A. parasiticus, and A. niger, all common food and agricultural contaminants. The essential oil exhibited significant antifungal activity, accompanied by notable antioxidant properties