The aim of this review article is to present, for the first time, an appraisal of the phytochemical, ethnobotanical and pharmacological data on Bunium species. The literature search was conducted using the Scopus, Google Scholar and PubMed databases. The genus Bunium has been found to produce both essential oil (EO) , mainly comprising monoterpenes and sesquiterpenes, and non-volatile components mainly

Rational modification of known drug candidates to design more potent ones using computational methods has found application in drug design, development, and discovery. Herein, we integrate computational and theoretical methodologies to unveil rivastigmine derivatives as dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) for Alzheimer's disease (AD) management. The investigation

Hernandulcin (HE) is a non-caloric sweetener biosynthezised by the Mexican medicinal plant Phyla scaberrima . Herein we present the results of HE production through cell suspensions of P. scaberrima as well as the influence of pH, temperature, biosynthetic precursors and potential elicitors to enhance HE accumulation. The incorporation of mevalonolactone (30-400 mg L -1 ) farnesol (30-400 mg L -1 )

Medicinal plants, are subjected to a variety of environmental stresses during their growth. Different factors including temperature, carbon dioxide, lighting, ozone, soil water, soil salinity and soil fertility has significant impact on medicinal plants' physiological and biochemical responses. Secondary metabolites (SMs) are useful for assessing the quality of therapeutic ingredients and nowadays

The aim of the present work is to isolate a series of triterpene derivatives with rhamnosyl linking acetyl groups from Glechoma longituba according to the structural characteristics of previously described triterpene saponins. The extract ion chromatography spectrum of the crude extract of G. longituba was detected and analyzed by HPLC-HRESIMS to determine possible components, and these metabolites

A new racemic xanthone, garmckeanin A ( 1 ), and eight known analogues 2 –9 were isolated from the ethyl acetate (EtOAc) extract of the Vietnamese Garcinia mckeaniana leaves. Their structures were determined by MS and NMR spectral analyses and compared with the literature. The EtOAC extract showed good cytotoxicity against cancer cell lines KB, Lu, Hep-G2 and MCF7, with IC 50 values of 5.40–8.76 µg/mL

Two new oleanane-triterpenoid saponins, clinograsaponins A ( 1 ) and B ( 2 ), together with twelve known ones ( 3−14 ), were isolated from the whole herb of Clinopodium gracile (Bentham) Matsumura. Their structures were determined by spectroscopic analysis and chemical method. All the isolated compounds were evaluated for their activities against ATP-citrate lyase (ACLY) and nuclear factor kappa B

Two new azaphilone compounds, daldinins G ( 1 ) and H ( 2 ), together with nine known compounds daldinin D ( 3 ), sargassopenilline B ( 4 ), austalide V ( 5 ), austalide K ( 6 ), austalide P ( 7 ), austalide P acid ( 8 ), austalide H ( 9 ), 13-O-deacetyaustalide I ( 10 ), and 17-O-demethylaustalide B ( 11 ), were isolated from the soft coral-derived fungus Penicillium glabrum glmu003. The new structures

A novel series of 2-chloroquinazoline derivatives had been synthesized and their anti-proliferation activities against the four EGFR high-expressing cells A549, NCI-H1975, AGS and HepG2 cell lines were evaluated. The preliminary SAR study of the scaffold of new compounds showed that the compounds with a chlorine substituent on R3 had a better anti-proliferation activity than those substituted by hydrogen

Fifteen chalcone derivatives 3a-3o were synthesized, and evaluated as multifunctional agents against Alzheimer’s disease. In vitro studies revealed that these compounds inhibited self-induced Aβ 1-42 aggregation effectively ranged from 45.9%-94.5% at 20 μM, and acted as potential antioxidants. Their structure–activity relationships were summarized. In particular, compound 3g exhibited an excellent

Untangling the most selective kinase inhibitors via pharmacological intervention remains one of the challenging affairs to date. Inaccordance to this drift, herein we describe the design and synthesis of a set of new heterocyclic analogues consisting of 6,7 dimethyl Quinoxaline, appended to a connector, employing Schiff base strategy (Compounds I – IX ). The compounds were characterised by various