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Proteomic Analysis of the Molecular Mechanisms of Chlorpromazine Inhibiting Migration of Oral Squamous Cell Carcinoma Curr. Proteom. (IF 0.8) Pub Date : 2024-02-27 Nannan Zhang, Junzhi Liu, Qiuping Dong, Chen Liu, Xinyu Liang, Peiyuan Tang, Zheng Liang
Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck region known for its high metastatic and invasive potential. Chlorpromazine (CPZ) has been shown to inhibit the growth of oral cancer cells. However, the effects of CPZ on OSCC migration and its underlying molecular mechanisms remain unclear. Objective: We aimed to identify global protein changes and potential
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LncRNA SH3BP5-AS1 Regulates the Proliferation and Cell Cycle of Non- Small Cell Lung Cancer Cells Curr. Proteom. (IF 0.8) Pub Date : 2023-12-20 Xiaowu Fan
Background: Non-small cell lung cancer (NSCLC) consists of a class of heterogeneous diseases. Objective: LncRNAs are exceedingly implicated in the pathogenesis of NSCLC. Herein, the current study set out to illustrate the molecular mechanism of SH3BP5-AS1 in NSCLC cells. Methods: SH3BP5-AS1 expression in clinical NSCLC tissues and its impact on prognosis were analyzed by bioinformatics database. SH3BP5-AS1
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Knockdown of miR-135a-5p Promotes Mitophagy by Regulating FoxO1/PINK1/Parkin Signaling in Hepatoma Cells Exposed to Oxidative Stress Curr. Proteom. (IF 0.8) Pub Date : 2023-12-08 Wang Zhenchang, Zhang Wenfu, Wu Shanshan, Yang Lei
Introduction: Excessive oxidative stress is always associated with hepatic disease, including hepatitis, liver fibrosis, and hepatocellular carcinoma (HCC). Despite this, the intricate molecular processes driving hepatocyte apoptosis due to oxidative stress remain incompletely comprehended. Aim: Consequently, we aimed to explore the role of miR-135a-5p in hepatoma cells (HepG2/3B). Method: The assessment
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PCM1: A Potential Prognostic Biomarker Correlated with Immune Infiltration in Lung Adenocarcinoma Curr. Proteom. (IF 0.8) Pub Date : 2023-12-08 Zhihua Guo, Jinghao Liang, Xin Zhang, Qing Ai, Zixian Xie, Haonan Zhao, Fayuan Wu, Zhaofeng Tan, Weiqiang Yin, Linghua Ji
Background: Recent studies have validated the role of Pericentriolar Material 1 (PCM1) in several malignant tumour cell lines, but its specific biological function in lung adenocarcinoma (LUAD) remains unclear. Objective: To address this gap, this study analyzed 411 LUAD and control samples to evaluate the prognostic value of PCM1 using Cox regression analysis. Methods: Multiple genes co-expressed
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Protein Profiling of Hirudo orientalis During Different Seasons for Obtaining Accurate Results in Leech Therapy Curr. Proteom. (IF 0.8) Pub Date : 2023-12-06 Leili Amani, Mehran Mirabzadeh Ardakani, Nasrin Motamed, Masuomeh Malek, Marzieh Dehghan Shasaltaneh
Objective: Leech therapy has been used for centuries as a recommended approach to cure several diseases, such as; psoriasis, arthrosclerosis, urinary tract diseases, and wound healing. The present study aimed to analyze the number, quantity, and distribution differences of medicinal leech (Hirudo orientalis) proteins throughout various seasons and in laboratory conditions as well. Methods: Protein
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Characterization of a New Hypotensive Peptide from the Venom of Snake Bothrops jararaca (Bj) Curr. Proteom. (IF 0.8) Pub Date : 2023-12-06 Ajoy Basak, Euridice Carmona, Felicia Au, Rosa Anna Maria Barbarulo Borgheresi
Background: Snake venom has become a key source of many bioactive peptides, enzymes, and toxins associated with blood coagulation and neuronal toxicity. In the past, a number of bradykinin potentiating peptides have been isolated from snake venom that display hypotensive activity due to their inhibitory action towards Angiotensin-Converting Enzyme (ACE). Significant interest has developed to isolate
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Interaction of C-terminal Truncated Beta-amyloid Peptides with Human Serum Albumin Curr. Proteom. (IF 0.8) Pub Date : 2023-11-28 Diba Aslani Firozabadi, Mohammad Reza Bozorgmehr, Safar Ali Beyramabadi, Sharareh Mohseni
Background: The formation of plaque from protein fibrils is the major source of diseases, such as Alzheimer's and Prion diseases. Amyloid beta (Aβ) is a peptide with different lengths, which is one of the main components of the plaque in the brain of people with Alzheimer's. Of the amyloid beta of various lengths in the brain cells plaque, beta-amyloid with 40 amino acids (Aβ1- 40) is more abundant
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Developing Multi-epitope Antigen Construct from Immunodominant Proteins for Serological Diagnosis of Chlamydia trachomatis: An In Silico Approach Curr. Proteom. (IF 0.8) Pub Date : 2023-10-27 Farideh Ghalamfarsa, Amir Savardashtaki, Cambyz Irajie, Amir Emami, Navid Nezafat, Younes Ghasemi
Background: Chlamydiasis is a widespread bacterial infection in the world. Serological tests are expensive, and in addition, intrinsic antigens can cause cross-reactions and make the diagnosis process difficult. Multi-epitope protein antigens are novel and potential diagnostic markers that have the capability of more accurate and cheaper diagnosis. Therefore, in this study, the main goal is to design
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Effects of Chronic Cold Exposure on Proteomics of Lung Tissue in Mice Curr. Proteom. (IF 0.8) Pub Date : 2023-10-26 Moyou Li, Ying Liu, Xiaoye Tian, Zhuojun Wang, Feng Cheng, Xiao Han, Zheyuan Chen, Ruihang Ma, Hongxu Jin
Background: Cold exposure can induce inflammation-related injury in lung tissue, but the exact mechanism is still unclear. Objective: The study aimed to clarify the proteomic characteristics of lung tissue under cold exposure. Methods: Forty mice were randomly equally divided into a control group and a model group. The model group was exposed to - 20°C for two weeks (4 hours per day), while the control
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RNA Sequencing of A2780 Cells Treated with CCL2 Identified Genes Associated with A2780 Cell Growth Curr. Proteom. (IF 0.8) Pub Date : 2023-10-20 Zhenling Ma, Lei Wang, Kun Cheng, Guozhen Xing, Jiajia Zhang, Wei Liu
Introduction: Ovarian cancer is a common gynecological malignancy. It is one of the leading causes of death among women worldwide. The incidence of ovarian cancer ranks third, and mortality is the first among gynecological malignant tumors. CCL2 (Chemokine C-C motif Ligand 2) is associated with the progression of a variety of tumors, including ovarian cancer. However, the mechanism of CCL2 in A2780
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Current Understanding of Dried Spots Platform for Blood Proteomics Curr. Proteom. (IF 0.8) Pub Date : 2023-08-15 Luis Perpétuo, Hugo Rocha, Rita Ferreira, Bruno Manadas, Francisco Amado, Sofia Guedes, Atef Mahmoud Mannaa, Jerome Vialaret, Christophe Hirtz, Rui Vitorino
Dry Blood Spots (DBS) have been used in combination with liquid chromatography-mass spectrometry for targeted proteomics to identify sensitive and specific novel biomarkers. DBS presents several advantages over other traditional blood sampling methods. This review discusses the past, present and future of the technology, focusing on studies with clinical and population relevance. Arguments for and
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Evaluation of the Interaction between Ricin Protein and Quercetin using Different Analytical Methods Curr. Proteom. (IF 0.8) Pub Date : 2023-08-10 Mayra Cristina Martínez-Ceniceros, Lenin Omar Nevarez-Prado, David Neder-Suarez, Fabiola Sandoval-Salas, Luz María Rodríguez-Valdez, Linda-Lucila Landeros-Martínez, Karla Bernal-Alvarado, León Hernández-Ochoa
Background: Ricin is the most toxic protein known. It is part of the ribosome-inactivating proteins, RIPs, type 2, which has generated importance in his research; it is possible to detoxify this protein with phenolic compounds; however, it is essential to understand how this detoxification occurs. To analyze using electrophoresis, UV-visible spectroscopy, and high-performance liquid chromatography
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Proteome Profiling of Serum Exosomes from Newborns with Lung Injury after Perinatal Asphyxia Curr. Proteom. (IF 0.8) Pub Date : 2023-07-21 Feifei Shen, Ying Li, Wenjing Gu, Xingmei Yu, Youjia Wu, Guihai Suo, Yuqin Zheng, Haiying Li, Chuangli Hao
Background: Neonate lung injury is a common phenomenon after perinatal asphyxia. Objective: To evaluate proteomic profiles of exosomes isolated from lung injury offspring serum after perinatal asphyxia. Methods: Serum samples were collected at 12 h, 24 h, and 72 h after birth in neonates with perinatal asphyxia-induced lung injury. Exosomes were isolated, and the concentration and size distribution
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Corrigendum to: Cancer Proteomics: New Horizons and Insights into Therapeutic Applications Curr. Proteom. (IF 0.8) Pub Date : 2023-07-19 Jaime Jacqueline Jayapalan, Perumal Subramanian, Puteri Shafinaz Abdul-Rahman
Following the publication of the original article [1], the authors reported that the complete grant number of the funding was omitted. In this correction, the incorrect and correct grant numbers are mentioned. The original publication of this article has been corrected. The funding acknowledgement published previously is as follows: The study was funded by Fundamental Research Grant Scheme (FRGS) by
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A Pan-Cancer Signature For S100A11 - Prognostic And Immunotherapeutic Value Curr. Proteom. (IF 0.8) Pub Date : 2023-06-01 Yali Le, Chenchen Geng, Guanghui Zhao, Xiaoqian Gao, Shuzhen Zhu, Ziqian Liu, Ping Zhang
Background: S100 calcium-binding protein A11 (S100A11) has important roles in tumorigenesis and multiple cancer progression. Amis: In this study, we aimed to analyze the expression and prognostic value of S100A11 across cancers and further explore the relationship between S100A11 and the tumor immune microenvironment. Methods: We analyzed the differential expression of S100A11 in the TIMER, GEPIA,
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Higher Abundance of Vitronectin (S-protein) in Serum-derived Exosomes of Pulmonary and Extra-Pulmonary Tuberculosis Patients as Compared to HIV-Tuberculosis Dual-infected Patients and Healthy Humans Curr. Proteom. (IF 0.8) Pub Date : 2023-05-26 Shweta Kushwaha, Rajbala Yadav, Kusuma Sai Davuluri, Anjana Goel, Devendra Singh Chauhan, Ajay Vir Singh
Background: Despite the crucial involvement of vitronectin in affecting the perseverance of certain respiratory pathogens and the progression of several lung diseases, the association of vitronectin with tuberculosis (TB) has been poorly studied. The present study aimed to determine whether vitronectin levels are altered in TB patients compared to healthy humans. Methods: Twenty-four laboratory-confirmed
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Integration of Proteomic Data Obtained from the Saliva of Children with Caries through Bioinformatic Analysis Curr. Proteom. (IF 0.8) Pub Date : 2023-04-28 Juan Manuel Guzman-Flores, Fernando Martínez-Esquivias, Julieta Sarai Becerra-Ruiz, Sandra Berenice Vázquez-Rodríguez
Background: Dental caries can affect the expression of salivary proteins. Proteomics allows us to analyze and identify many proteins in a single sample and experiment; bioinformatics is essential to analyze proteomic data. Objective: This research aims to identify and integrate the main differentially expressed proteins in the saliva of children with caries, infer their Gene Ontology and interactions
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ORF7a Palsies Macrophage to Worsen Diabetes by SMB/BPI/ABC Domains and PARP/Cap/Cyclin Enzyme System Curr. Proteom. (IF 0.8) Pub Date : 2023-04-18 Wenzhong Liu, Hualan Li
Background: Such factors as diabetes and obesity can dramatically worsen COVID-19 symptoms. In addition, macrophage accumulation in adipose tissue is related to obesity. Therefore, macrophages play a significant role in raising COVID-19 susceptibility and severity in diabetes and obese patients. Methods: In this study, the functional impact of SARS-CoV-2 ORF7a on macrophages was analyzed using a domain-searching
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LINC00839, LINC01671, AC093673 and AC008760 are Associated with the Prognosis and Immune Infiltration of Clear-cell Renal Cell Carcinoma Curr. Proteom. (IF 0.8) Pub Date : 2023-04-11 Xun-Da Ye, Zhang-Xiong Huang, Yu-Wei Song, San-Huang Xu, Bao-Chang Su, Sheng-Fu Yang
Background: Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, and it is a significant global health problem causing significant morbidity and mortality. Long noncoding RNAs (lncRNAs) have been identified as a class of gene expression regulators that play a critical role in the immune system. However, the function of lncRNAs in the immune microenvironment of ccRCC remains
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Pilot Study of the Ex Vivo Blood Leukocytes’ Proteomic Response to Prednisone Stimulation in Corticosteroid-responsive Asthma Curr. Proteom. (IF 0.8) Pub Date : 2023-03-20 Aleksandra Nikolic, Kevin J. Mark, Sandra Dragicevic, Tamara Babic, Katarina Milosevic, Branimir Nestorovic, Vladimir Beskoski
Background: Leukocytes are key cellular effectors of inflammation in asthma and understanding their function in this disease is of crucial importance. Blood leukocytes reflect the actions of their counterparts in the lungs and they can be obtained through minimal invasive procedures as part of the peripheral blood. Objective: The aim of the study was to identify proteins in blood leukocyte proteomes
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Proteomics of the Skin Secretion of Pulchrana glandulosa (Anura: Ranidae) (Boulenger, 1882), Langkawi Island, Kedah, Peninsular Malaysia Curr. Proteom. (IF 0.8) Pub Date : 2022-12-26 Dasi Ong, Mohd Nazri Ismail, Shahriza Shahrudin
Background: The advancement of proteomics studies leads to various benefits in research. However, in Malaysia, proteomics studies are still in their early stage. Objective: Four adult Pulchrana glandulosa individuals were collected from the stream of Temurun Waterfall for their proteomics information. Methods: These frogs’ skin secretions were collected, extracted, and analysed for their protein antimicrobial
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Heavy Metal Stress Tolerance by Serratia nematodiphila sp. MB307: Insights from Mass Spectrometry-based Proteomics Curr. Proteom. (IF 0.8) Pub Date : 2022-11-29 Zarrin Basharat, Kyung-Mee Moon, Leonard J. Foster, Azra Yasmin
Background: Heavy metals impact living organisms deleteriously when they exceed the required limits. Their remediation by bacteria is a much-pursued area of environmental research. In this study, we explored the quantitative changes of four heavy metals (cadmium, chromium, zinc, copper), on the global and membrane proteome of gram-negative S. nematodiphila MB307. This is a versatile bacterium, isolated
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Predicting the Secondary Structure of Proteins: A Deep Learning Approach Curr. Proteom. (IF 0.8) Pub Date : 2022-11-01 Charu Kathuria, Deepti Mehrotra, Navnit Kumar Misra
Background: The machine learning computation paradigm touched new horizons with the development of deep learning architectures. It is widely used in complex problems and achieved significant results in many traditional applications like protein structure prediction, speech recognition, traffic management, health diagnostic systems and many more. Especially, Convolution neural network (CNN) has revolutionized
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Unraveling Major Proteins of Mycobacterium tuberculosis Envelope Curr. Proteom. (IF 0.8) Pub Date : 2022-10-13 Rananjay Singh, Devesh Sharma, Divakar Sharma, Sakshi Gautam, Mahendra Kumar Gupta, Deepa Bisht
Although treatable, resistant form of tuberculosis (TB) has posed a major impediment to the effective TB control programme. As the Mycobacterium tuberculosis cell envelope is closely associated with its virulence and resistance, it is very important to understand the cell envelope for better treatment of causative pathogens. Cell membrane plays a crucial role in imparting various cell functions. Proteins
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Methanol and Sorbitol Affect the Molecular Dynamics of Arginine Deiminase: Insights for Improving its Stability Curr. Proteom. (IF 0.8) Pub Date : 2022-08-20 Mahboubeh Zarei, Soudabeh Sabetian, Mohammad Reza Rahbar, Manica Negahdaripour
Background: The arginine deiminase enzyme of Mycoplasma arginini (MaADI) is a potential anti-cancer agent for treating arginine-auxotrophic cancers. Investigating the protein stability in the presence of osmolytes can help to increase protein stability under various stressed conditions. Methods: In this study, the stability and dynamics of MaADI were investigated in pure water and solutions of 1 M
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Proteomic Analysis of Early Phosphorylated Proteins in Acute Pancreatitis Model Curr. Proteom. (IF 0.8) Pub Date : 2021 Pengcheng Zhang
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Cloning, Expression and Biochemical Characterization of the Recombinant α-amylase from Bacillus subtilis YX48 Curr. Proteom. (IF 0.8) Pub Date : 2021 Yan Shan
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Analysis of Membrane Proteins of Streptomycin-Resistant Mycobacterium tuberculosis Isolates Curr. Proteom. (IF 0.8) Pub Date : 2022-06-28 Rananjay Singh, Devesh Sharma, Divakar Sharma, Mahendra Kumar Gupta, Deepa Bisht
Background: Drug-resistant tuberculosis remains a health security threat and resistance to second-line drugs limits the options for treatment. Consequently, there is an utmost need for identifying and characterizing new biomarkers/drug targets of prime importance. Membrane proteins have an anticipated role in biological processes and could qualify as biomarkers/drug targets. Streptomycin (SM) is recommended
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Identification of Human Protein Subcellular Location with Multiple Networks Curr. Proteom. (IF 0.8) Pub Date : 2022-06-01 Lei Chen, Rui Wang
Background: Protein function is closely related to its location within the cell. Determination of protein subcellular location is helpful in uncovering its functions. However, traditional biological experiments to determine the subcellular location are of high cost and low efficiency, which cannot meet today’s needs. In recent years, many computational models have been set up to identify the subcellular
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Proteomics, Peptidomics and Transcriptomic Analysis of the Venom from the Spider Macrothele yani (Mygalomorphae: Macrothelidae) Curr. Proteom. (IF 0.8) Pub Date : 2022-05-09 Yu Zhao, Zi-Zhong Yang, Xiao-Liang Gu, Ying Wang, Cheng-Gui Zhang, Xiu-Mei Wu, Huai Xiao, Yin-He Yang, Da-Song Yang, Zhi-Bin Yang
Background: Spider venom show abundant diversity in both peptides and proteins, which play essential roles in new drug development and agrochemistry. The venoms of Macrothele yani species have strong toxicity on the victims. Objective: The purpose of this study is to comprehensively characterize the profile of venom proteins and peptides of spider Macrothele yani mainly inhabiting Yunnan province,
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Proteomics and Computational Analysis of Cytosolic Proteome of a Thermoacidophilic Euryarchaeon, Picrophilus torridus Curr. Proteom. (IF 0.8) Pub Date : 2022-05-09 Manisha Goel, Neelja Singhal, Anjali Garg, Nirpendra Singh, Manish Kumar
Background: Picrophilus torridus is a thermoacidophilic archaeon that thrives in an extremely low pH (0-1) and high temperatures (50-60°C). Thus, it is a suitable organism to study microbial genetics and metabolic adaptations to the extremely acidic and moderate thermal environment. Objective: In the present study we have conducted a global proteome analysis of P. torridus and discerned the cytosolic
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Proteomic Profiling of Maternal Serum for Early Risk Analysis of Preterm Birth Curr. Proteom. (IF 0.8) Pub Date : 2022-04-15 Nabila Roohi, Javeria Malik, Shaaf Ahmad, Humaira Aziz, Muhammad Amir Iqbal
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Identification of Potential Immunogenic Epitopes against SARS-CoV-2 using In-Silico Method: An Immunoinformatics Study Curr. Proteom. (IF 0.8) Pub Date : 2022-04-01 Subikshaa. S,Sathishnath. P,Chethan Jaya Sai Nandamuri,Shruti Ramanathan,Shobana Sugumar
Background:Severe Acute Respiratory Syndrome (SARS-CoV-2), a zoonotic virus, is the pathogenic causal agent for the ongoing pandemic. Despite the lethality of the disease, there are no therapeutic agents available to combat the disease outbreak; and the vaccines currently accessible are insufficient to control the widespread, fast-mutating virus infection.Objective:This research study focuses on determining
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Meet the Editorial Board Member Curr. Proteom. (IF 0.8) Pub Date : 2022-04-01 Naveena B. Maheswarappa
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Bioinformatics-Based Characterization of Proteins Related to SARS-CoV- 2 Using the Polarity Index Method® (PIM®) and Intrinsic Disorder Predisposition Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Carlos Polanco,Vladimir N. Uversky,Guy W. Dayhoff,Alberto Huberman,Thomas Buhse,Manlio F. Márquez,Gilberto Vargas-Alarcón,Jorge Alberto Castañón-González,Leire Andrés,Juan Luciano Dı́az-González,Karina González-Bañales
Background:The global outbreak of the 2019 novel Coronavirus Disease (COVID-19) caused by the infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which appeared in China at the end of2019, signifies a major public health issue at the current time.Objective: The objective of the present study is to characterize the physicochemical properties of the SARS-CoV-2 proteins at
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Characterization of Proteins from Putative Human DNA and RNA Viruses Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Carlos Polanco,Vladimir N. Uversky,Gilberto Vargas-Alarcón,Thomas Buhse,Alberto Huberman,Manlio F. Márquez,Leire Andrés
Background: In the vast variety of viruses known, there is a particular interest in those transmitted to humans and whose ability to disseminate represents a significant public health issue. Objective: The present study’s objective is to bioinformatically characterize the proteins of the two main divisions of viruses, RNA-viruses and DNA-viruses. Methods:In this work, a set of in-house computational
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Cytotoxic and Apoptotic Effect of Iris taochia Plant Extracts on Human Breast Cancer (MCF-7) Cells Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Burak Yazgan,Ozlem Ozcelik,Arif Ayar,Gülin Renda,Tuba Yıldırım
Introduction:Iris taochia is an endemic plant in Turkey. Iris species has many biologicaleffects such as antibacterial, antiinflammatory, antioxidant and anticancer properties. Apoptosisis a programmed cell death and this mechanism regulates the death of cancer cells.Purpose:The aim of our work is to investigate how the Iris taochia extracts affect the apoptotic activityin the MCF7 cells.Methods:Cytotoxic
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Bioinformatics-Based Characterization of Proteins Related to SARS-CoV- 2 Using the Polarity Index Method® (PIM®) and Intrinsic Disorder Predisposition Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Carlos Polanco,Vladimir N. Uversky,Guy W. Dayhoff,Alberto Huberman,Thomas Buhse,Manlio F. Márquez,Gilberto Vargas-Alarcón,Jorge Alberto Castañón-González,Leire Andrés,Juan Luciano Dı́az-González,Karina González-Bañales
Background:The global outbreak of the 2019 novel Coronavirus Disease (COVID-19) caused by the infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which appeared in China at the end of2019, signifies a major public health issue at the current time.Objective: The objective of the present study is to characterize the physicochemical properties of the SARS-CoV-2 proteins at
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Curcumin Reverts the Protein Differential Expression in the Liver of the Diabetic Obese db/db Mice Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Oscar Gerardo Silva-Gaona,Juan Manuel Guzmán-Flores,Magdalena Hernández-Ortiz,Katya Vargas-Ortiz,Joel Ramírez-Emiliano,Sergio Encarnación-Guevara,Victoriano Pérez-Vázquez
Background: In type 2 diabetic mouse liver, hyperglycemia, and insulin modify gene expression. Curcumin is apowerful antioxidant and antidiabetic agent that regulates the gene expression of different signaling pathways throughvarious transcription factors. Therefore, we hypothesized that curcumin modifies the protein expression profile in the liverof diabetic db/db mice.Objective:To determine the effects
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Differential Proteomic Identification and Bioinformatics Analysis of Femoral Neck in Elderly Female Patients with Hyperuricaemia Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Yingyi He,Guangming Zhang,Yuyang Huang,Qi Li,Cheng Luo
Background:Serum uric acid (UA) is positively correlated with bone mineral density (BMD). However, the mechanism by which serum UA affects BMD remains unclear.Objective:The aim was carried out to search for the functional proteins related to serum UA and femoral neck BMD to better understand the pathophysiological mechanism of osteoporosis.Materials and Methods:In this study, patients in the UA group
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Effective Inhibition of Mitochondrial Metabolism by Cryptotanshinone in MDA-MB231 cells: A Proteomic Analysis Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Jiefeng Zhou,Qingcao Li,Haoran Wu,Shin-Han Tsai,Yu-Ting Yeh
Background :Triple-negative breast cancer (TNBC) is a subtype of invasive cancer in breast with the symptoms of unfavourable prognosis and limited targeted treatment options. Evidence of changes in the metabolic status of TNBC, characterised by increased glycolysis, mitochondrial oxidative phosphorylation, as well as production and utilization of tricarboxylic acid cycle intermediates.Objective:Investigate
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Protein Aggregation and Self Assembly in Health and Disease Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Ajoy Basak,Sarmistha Basak
:Self-attachment of proteins leading to the formation of highly insoluble protein oligomers and aggregates has become an important focus of research owing to its diverse implications in pathophysiology and diseases. This has become a more frequent phenomenon in most neurological and neurodegenerative diseases as well as in dementia. In recent years such event of protein aggregation has linked to other
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The Epidemiological and Pangenome Landscape of Staphylococcus aureus and Identification of Conserved Novel Candidate Vaccine Antigens Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Kanwal Naz,Nimat Ullah,Anam Naz,Sidra Irum,Hamza Arshad Dar,Tahreem Zaheer,Fatima Shahid,Amjad Ali
Background and Objective: Staphylococcus aureus (S. aureus) is a gram-positive bacterium and one of the major nosocomial pathogen. It has the ability to acquire resistance against almost all available classes of antibiotics; Methicillin-Resistant S. aureus (MRSA) is a well-known antibiotic resistance. S. aureus is a globally distributed pathogen that need in-depth epidemiological and genomic level
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Expression Analysis of 4-Hydroxynonenal Modified Proteins in Schizophrenia Brain; Relevance to Involvement in Redox Dysregulation Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Sobia Manzoor,Ayesha Khan,Beena Hasan,Shamim Mushtaq,Nikhat Ahmed
Background:Oxidative damage contributes to the pathophysiology of schizophrenia (SZ). Redox imbalance maylead to increased lipid peroxidation, which produces toxic aldehydes like 4-hydroxynonenal (4-HNE) ultimately leading tooxidative stress. Conversely, implications of oxidative stress points towards an alteration in HNE-protein adducts andactivities of enzymatic and antioxidant systems in schizophrenia
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Critical Residues in Hsp70 Nucleotide Binding Domain for Challenges in Drug Design Curr. Proteom. (IF 0.8) Pub Date : 2022-02-01 Mustafa Ergul,Fugen Aktan,Yusuf Tutar
Background:The association of a drug with its target protein correlates to its medicinalactivity and the microenvironment plays a key role in this association. The key challenge is to identifymutations which unlikely to respond to designed drugs.Objective:Hsp70 is an anti-apoptotic factor and tumor cells overexpress Hsp70 to survive againstanti-cancer agents. The impact of pathogenic mutations on Hsp70
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Metabolomics of meat color: Practical implications Curr. Proteom. (IF 0.8) Pub Date : 2021-12-30 Morgan L. Denzer,Frank Kiyimba,Gretchen G. Mafi,Ranjith Ramanathan
Objective:Meat is biochemically active, and the various pre-and post-harvest processescan affect meat quality. Metabolomics is a valuable tool to elucidate metabolite changes in meat.The overall goal of this study was to provide an overview of various techniques, data analysis, andapplication of metabolomics in meat color research.Results:Both targeted and non-targeted approaches have been used to
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Machine Learning for Mass Spectrometry Data Analysis in Proteomics Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Juntao, Li
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Prediction of Protein Structural Classes: Features Extraction to Classification Algorithm Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Xiaoqing, Liu
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Identifying Protein Subcellular Location with Embedding Features Learned from Networks Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Hongwei, Liu
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A Useful Tool for the Identification of DNA-Binding Proteins Using Graph Convolutional Network Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Dasheng, Chen
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Prediction of Nitration Sites Based on FCBF Method and Stacking Ensemble Model Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Min, Liu
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Comparative Proteomic Analysis of Hydrogen Peroxide-Induced Protein Expression in Streptococcus pneumoniae D39 Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Sungkyoung, Lee
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Heteromerization as a Mechanism Modulating the Affinity of the ACE2 Receptor to the Receptor Binding Domain of SARS-CoV-2 Spike Protein Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Diego, Guidolin
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Proteomic Study of the Mechanism of Talin-C as an Inhibitor of HIV Infection Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Lin, Yin
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Proteomic Analysis of Aqueous Humor Proteins Associated with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Ying, Wang
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A Bottom-Up Proteomic Approach in Bone Marrow Plasma Cells of Newly Diagnosed Multiple Myeloma Patients Curr. Proteom. (IF 0.8) Pub Date : 2021-09-30 Beycan, Ayhan