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Bee Bread: A Promising Source of Bioactive Compounds with Antioxidant Properties—First Report on Some Antimicrobial Features Antioxidants (IF 7.0) Pub Date : 2024-03-15 Cornelia-Ioana Ilie, Angela Spoiala, Elisabeta-Irina Geana, Cristina Chircov, Anton Ficai, Lia-Mara Ditu, Eliza Oprea
Bee bread has received attention due to its high nutritional value, especially its phenolic composition, which enhances life quality. The present study aimed to evaluate the chemical and antimicrobial properties of bee bread (BB) samples from Romania. Initially, the bee bread alcoholic extracts (BBEs) were obtained from BB collected and prepared by Apis mellifera carpatica bees. The chemical composition
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Nanoemulsions of Phoenix dactylifera L. (Decaffeinated) and Coffea arabica L. Extracts as a Novel Approach for the Treatment of Carbon Tetrachloride-Mediated Liver Fibrosis Antioxidants (IF 7.0) Pub Date : 2024-03-16 Eman S. Alamri, Hala M. Bayomy, Mohamed A. Mohamady Hussein, Nawal A. Ozaybi, Seham E. Almasoudi, Nahla S. Zidan, Renad A. Albalwi, Hebatallah H. Atteia, Fayza M. EL-Ezaly
Liver fibrosis is a condition characterized by the excessive buildup of scar tissue in the liver. This scarring occurs as a result of chronic liver damage, often caused by conditions such as hepatitis, alcohol abuse, certain metabolic disorders, genetic abnormalities, autoimmunity, and noninfectious diseases such as fatty liver which leads to liver fibrosis. Nanoparticles have gained attention in recent
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Selenomethionine Alleviates Deoxynivalenol-Induced Oxidative Injury in Porcine Intestinal Epithelial Cells Independent of MAPK Pathway Regulation Antioxidants (IF 7.0) Pub Date : 2024-03-16 Zhouyin Huang, Haopeng Zhong, Ting Li, Zirui Wang, Xingping Chen, Tiande Zou, Jinming You, Jun Chen
Deoxynivalenol (DON) is a prevalent contaminant in feed and food, posing a serious threat to the health of both humans and animals. The pig stands as an ideal subject for the study of DON due to its recognition as the most susceptible animal to DON. In this study, the IPEC-J2 cells were utilized as an in vitro model to explore the potential of SeMet in alleviating the intestinal toxicity and oxidative
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Norcantharidin Sensitizes Colorectal Cancer Cells to Radiotherapy via Reactive Oxygen Species–DRP1-Mediated Mitochondrial Damage Antioxidants (IF 7.0) Pub Date : 2024-03-14 Qiong Xu, Heng Zhang, Haoren Qin, Huaqing Wang, Hui Wang
Norcantharidin (NCTD), a cantharidin derivative, induces ROS generation and is widely used to treat CRC. In this study, we clarified the role and mechanism of action of norcantharidin in increasing CRC sensitivity to radiotherapy. We treated the CRC cell lines LoVo and DLD-1 with NCTD (10 or 50 μmol/L), ionizing radiation (IR, 6 Gy), and a combination of the two and found that NCTD significantly inhibited
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Porcine Granulosa-Cell-Derived Exosomes Enhance Oocyte Development: An In Vitro Study Antioxidants (IF 7.0) Pub Date : 2024-03-14 Jiajie Ren, Yue Ding, Junsong Shi, Shengchen Gu, Lvhua Luo, Zhihao Feng, Ting Gu, Zheng Xu, Sixiu Huang, Zicong Li, Zhenfang Wu, Gengyuan Cai, Linjun Hong
Recent studies have established that exosomes (EXs) derived from follicular fluid (FF) can promote oocyte development. However, the specific sources of these EXs and their regulatory mechanisms remain elusive. It is universally acknowledged that oocyte development requires signal communication between granulosa cells (GCs) and oocytes. However, the role of GC-secreted EXs and their functions are poorly
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Evaluation of Sample Size Influence on Chemical Characterization and In Vitro Antioxidant Properties of Flours Obtained from Mushroom Stems Coproducts Antioxidants (IF 7.0) Pub Date : 2024-03-14 Patricia Bermúdez-Gómez, Juana Fernández-López, Margarita Pérez-Clavijo, Manuel Viuda-Martos
The mushroom industry generates large amounts of stem co-product. This is generated after mushroom harvest; stems are attached to the growth substratum, and their only use has traditionally been as compost. In this study, we investigated extensively for the first time this co-product and the influence of sample size (L—>0.510 mm; LI—0.510–0.315 mm; SI—0.315–0.180 mm; S—<0.180 mm) on the characterization
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Two-Generation Toxicity Study of the Antioxidant Compound Propyl-Propane Thiosulfonate (PTSO) Antioxidants (IF 7.0) Pub Date : 2024-03-15 Antonio Cascajosa-Lira, Remedios Guzmán-Guillén, Silvia Pichardo, Alberto Baños, Jose M. de la Torre, Nahum Ayala-Soldado, M. Rosario Moyano-Salvago, Isabel Ortiz-Jaraba, Ana M. Cameán, Angeles Jos
Propyl-propane thiosulfonate (PTSO), an antioxidant organosulfur compound present in the genus Allium, has become a potential natural additive for food and feed, as well as a possible biopesticide for pest control in plants. A toxicological assessment is necessary to verify its safety for livestock, consumers, and the environment. As part of the risk assessment of PTSO, this study was designed to explore
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N-Acetylcysteine, N-Acetylcysteine Amide, and Thioredoxin Mimetic Peptides Regenerate Mercaptoalbumin and Exhibit Antioxidant Activity Antioxidants (IF 7.0) Pub Date : 2024-03-15 Sonia Eligini, Marco Munno, Gloria Modafferi, Daphne Atlas, Cristina Banfi
Albumin (HSA) is the most abundant circulating protein and plays a pivotal role in maintaining the redox state of the plasma. Three HSA proteoforms have been identified based on the redox state of cysteine 34. These proteoforms comprise of the reduced state (HSA-SH) referred to as mercaptoalbumin, non-mercaptoalbumin-1, containing a disulfide with small thiols such as cysteine (HSA-Cys), and non-mercaptoalbumin-2
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Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications Antioxidants (IF 7.0) Pub Date : 2024-03-15 Zhili Wu, Yanru Zhu, Wenchao Liu, Balamuralikrishnan Balasubramanian, Xiao Xu, Junhu Yao, Xinjian Lei
Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body, the liver is crucial for iron storage and lipid metabolism. The liver seems to be closely related to ferroptosis through iron and lipid metabolism. Liver disease greatly threatens host health, and exploring effective interventions
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Systemic Oxidative Stress in Subacute Stroke Patients Undergoing Rehabilitation Treatment Antioxidants (IF 7.0) Pub Date : 2024-03-15 Carola Cocco, Mariacristina Siotto, Alessandro Guerrini, Marco Germanotta, Caterina Galluccio, Valeria Cipollini, Laura Cortellini, Arianna Pavan, Stefania Lattanzi, Sabina Insalaco, Elisabetta Ruco, Rita Mosca, Biagio Campana, Irene Aprile
The imbalance in oxidative stress in acute stroke has been extensively studied; on the contrary, its investigation in the subacute phase is limited. The aim of this study was to analyse the variation in the systemic oxidative status in subacute post-stroke patients before (T0) and after a six-week rehabilitation treatment (T1) and to investigate the relationship between systemic oxidative status and
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Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Crataegus pinnatifida Bunge Variety—Daehong Antioxidants (IF 7.0) Pub Date : 2024-03-12 Kang-In Lee, Yousang Jo, Heung Joo Yuk, Sun-Young Kim, Hyungjun Kim, Hye Jin Kim, Soo-Keol Hwang, Ki-Sun Park
Developing new plant varieties plays a crucial role in competitiveness in the agricultural and food industries and enhancing food security. Daehong (DH) is a new variety of Crataegus pinnatifida Bunge (CP); however, its physiological functions and potential as a nutraceutical ingredient remain unknown. Here, the efficacy of DH on inflammatory bowel disease (IBD) was investigated using dextran sulfate
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Phytochemical Characterization and Antibacterial Activity of Albanian Juniperus communis and Juniperus oxycedrus Berries and Needle Leaves Extracts Antioxidants (IF 7.0) Pub Date : 2024-03-13 Ilir Mërtiri, Bogdan Păcularu-Burada, Nicoleta Stănciuc
This paper aims to investigate the phytochemical profile and in vitro antibacterial activity of two juniper species collected in Albania, Juniperus communis and Juniperus oxycedrus. The berries and the needle leaves were subjected to solid–liquid solvent ultrasound-assisted extraction. The phytochemical characterization of the extracts was performed by spectrophotometric and chromatographic means.
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Effects of Aspirin Eugenol Ester on Liver Oxidative Damage and Energy Metabolism in Immune-Stressed Broilers Antioxidants (IF 7.0) Pub Date : 2024-03-13 Jiale Zhong, Wenrui Zhen, Dongying Bai, Xiaodi Hu, Haojie Zhang, Ruilin Zhang, Koichi Ito, Yi Zhang, Bingkun Zhang, Yanbo Ma
The aim of this study was to investigate the effects of aspirin eugenol ester (AEE) on liver oxidative damage and energy metabolism in immune-stressed broilers. In total, 312 broilers were divided into 4 groups (saline, LPS, SAEE, and LAEE). Broilers in the saline and LPS groups were fed a basal diet; the SAEE and LAEE groups had an added 0.01% AEE in their diet. Broilers in the LPS and LAEE groups
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Evaluating the Neuroprotective Potential of Caffeinated Coffee in the Context of Aluminum-Induced Neurotoxicity: Insights from a PC12 Cell Culture Model Antioxidants (IF 7.0) Pub Date : 2024-03-13 Kamil Rodak, Dorota Bęben, Monika Birska, Oliwia Siwiela, Izabela Kokot, Helena Moreira, Anna Radajewska, Anna Szyjka, Ewa Maria Kratz
Exposure to aluminum (Al) and its compounds is an environmental factor that induces neurotoxicity, partially through oxidative stress, potentially leading to the development of neurodegenerative diseases. Components of the diet, such as caffeinated coffee, may play a significant role in preventing these diseases. In the present study, an experimental model of PC12 cells (rat pheochromocytoma tumor
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CASK Mediates Oxidative Stress-Induced Microglial Apoptosis-Inducing Factor-Independent Parthanatos Cell Death via Promoting PARP-1 Hyperactivation and Mitochondrial Dysfunction Antioxidants (IF 7.0) Pub Date : 2024-03-13 Keith Jun Hao Cheong, Duen-Yi Huang, Ponarulselvam Sekar, Rou Jhen Chen, Irene Han-Juo Cheng, Chi-Ming Chan, Yuan-Shen Chen, Wan-Wan Lin
Calcium/calmodulin-dependent serine protein kinase (CASK) is a scaffold protein and plays critical roles in neuronal synaptic formation and brain development. Previously, CASK was shown to associate with EGFR to maintain the vulval cell differentiation in C. elegans. In this study, we explored the role of CASK in CHME3 microglial cells. We found that CASK silencing protects cells from H2O2-induced
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The Potential Role of Major Argan Oil Compounds as Nrf2 Regulators and Their Antioxidant Effects Antioxidants (IF 7.0) Pub Date : 2024-03-13 Riad El Kebbaj, Habiba Bouchab, Mounia Tahri-Joutey, Soufiane Rabbaa, Youness Limami, Boubker Nasser, Melford C. Egbujor, Paolo Tucci, Pierre Andreoletti, Luciano Saso, Mustapha Cherkaoui-Malki
In recent years, research on the discovery of natural compounds with potent antioxidant properties has resulted in growing interest in these compounds due to their potential therapeutic applications in oxidative-stress-related diseases. Argan oil, derived from the kernels of a native tree from Morocco, Argania spinosa, is renowned for its rich composition of bioactive compounds, prominently tocopherols
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Screening for Metal-Chelating Activity in Potato Protein Hydrolysates Using Surface Plasmon Resonance and Peptidomics Antioxidants (IF 7.0) Pub Date : 2024-03-13 Mads Bjørlie, Julie Christina Hartmann, Line Hyrup Rasmussen, Betül Yesiltas, Ann-Dorit Moltke Sørensen, Simon Gregersen Echers, Charlotte Jacobsen
Metal-catalyzed lipid oxidation is a major factor in food waste, as it reduces shelf life. Addressing this issue, our study investigates the potential of hydrolysates derived from potato protein, a by-product of potato starch production, as metal-chelating antioxidants. Through sequential enzymatic hydrolysis using alcalase or trypsin combined with Flavourzyme, we produced various hydrolysates, which
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Simvastatin-Mediated Nrf2 Activation Induces Fetal Hemoglobin and Antioxidant Enzyme Expression to Ameliorate the Phenotype of Sickle Cell Disease Antioxidants (IF 7.0) Pub Date : 2024-03-11 Caixia Xi, Chithra Palani, Mayuko Takezaki, Huidong Shi, Anatolij Horuzsko, Betty S. Pace, Xingguo Zhu
Sickle cell disease (SCD) is a pathophysiological condition of chronic hemolysis, oxidative stress, and elevated inflammation. The transcription factor Nrf2 is a master regulator of oxidative stress. Here, we report that the FDA-approved oral agent simvastatin, an inhibitor of hydroxymethyl-glutaryl coenzyme A reductase, significantly activates the expression of Nrf2 and antioxidant enzymes. Simvastatin
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Comparison of Milk Kefirs Obtained from Cow’s, Ewe’s and Goat’s Milk: Antioxidant Role of Microbial-Derived Exopolysaccharides Antioxidants (IF 7.0) Pub Date : 2024-03-11 Sana M’hir, Lamia Ayed, Ilaria De Pasquale, Elisabetta Fanizza, Ali Zein Alabiden Tlais, Roberto Comparelli, Michela Verni, Rosanna Latronico, Marco Gobbetti, Raffaella Di Cagno, Pasquale Filannino
Different types of milk are used in the production of milk kefir, but little information is available on the release of potentially antioxidant exopolysaccharides (EPS). The aim of this study was to investigate whether the microbial dynamics and EPS release are dependent on the milk substrate. In our study, the inoculated microbial consortium was driven differently by each type of milk (cow, ewe, and
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A Comparison of the Antioxidant Potential and Metabolite Analysis of Marine Fungi Associated with the Red Algae Pterocladiella capillacea from Northern Taiwan Antioxidants (IF 7.0) Pub Date : 2024-03-11 Jiji Kannan, Ka-Lai Pang, Ying-Ning Ho, Pang-Hung Hsu, Li-Li Chen
This study represents a primary investigation centered on screening six marine fungi, Emericellopsis maritima, Engyodontium album, Hypomontagnella monticulosa, Hortaea werneckii, Trichoderma harzianum, and Aspergillus sp.7, associated with the red algae Pterocladiella capillacea, which was collected from Chao-Jin Park in Keelung, Taiwan, as potential immunostimulants for shrimp aquaculture. Recognizing
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Phytonutritional Composition and Antioxidant Properties of Southern African, Purple-Fleshed Sweet Potato (Ipomoea batatas (L.) Lam.) Storage Roots Antioxidants (IF 7.0) Pub Date : 2024-03-11 Ayanda A. Ngcobo, Sephora Mutombo Mianda, Faith Seke, Laurie M. Sunette, Dharini Sivakumar
Purple sweet potatoes (Ipomoea batatas (L.) genotype) in Southern Africa have a phytonutritional composition and antioxidant properties that can increase incomes and improve nutrition. This study compared the phytonutrient composition and antioxidant properties of four purple-colour sweet potato genotypes (local Purple-purple, ‘2019-1-1’, and USA genotypes, ‘08-21P’ and ‘16-283P’). These purple sweet
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Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome Antioxidants (IF 7.0) Pub Date : 2024-03-11 Iva Klobučar, Lidija Hofmann, Hansjörg Habisch, Margarete Lechleitner, Lucija Klobučar, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Tobias Madl, Saša Frank, Vesna Degoricija
The association between advanced oxidation protein products (AOPPs) and lipoprotein subclasses remains unexplored. Therefore, we performed comprehensive lipoprotein profiling of serum using NMR spectroscopy and examined the associations of lipoprotein subclasses with the serum levels of AOPPs in healthy volunteers (HVs) and patients with metabolic syndrome (MS). The serum levels of AOPPs were significantly
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Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review Antioxidants (IF 7.0) Pub Date : 2024-03-10 Nemanja Živanović, Marija Lesjak, Nataša Simin, Surjit K. S. K. S. Srai
Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of glutathione, and extensive lipid peroxidation of lipids in the cell membrane. It was discovered
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Antioxidant Responses and Phytochemical Accumulation in Raphanus Species Sprouts through Elicitors and Predictive Models under High Temperature Stress Antioxidants (IF 7.0) Pub Date : 2024-03-08 María-Trinidad Toro, Roberto Fustos-Toribio, Jaime Ortiz, José Becerra, Nelson Zapata, María Dolores López-Belchí
Crop production is being impacted by higher temperatures, which can decrease food yield and pose a threat to human nutrition. In the current study, edible and wild radish sprouts were exposed to elevated growth temperatures along with the exogenous application of various elicitors to activate defense mechanisms. Developmental traits, oxidative damage, glucosinolate and anthocyanin content, and antioxidant
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Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment Antioxidants (IF 7.0) Pub Date : 2024-03-08 Caroline Bertoncini-Silva, Adelina Vlad, Roberta Ricciarelli, Priscila Giacomo Fassini, Vivian Marques Miguel Suen, Jean-Marc Zingg
Curcumin, a natural polyphenolic component from Curcuma longa roots, is the main bioactive component of turmeric spice and has gained increasing interest due to its proposed anti-cancer, anti-obesity, anti-inflammatory, antioxidant, and lipid-lowering effects, in addition to its thermogenic capacity. While intake from dietary sources such as curry may be sufficient to affect the intestinal microbiome
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8-OxoG-Dependent Regulation of Global Protein Responses Leads to Mutagenesis and Stress Survival in Bacillus subtilis Antioxidants (IF 7.0) Pub Date : 2024-03-08 Lissett E. Martínez, Gerardo Gómez, Norma Ramírez, Bernardo Franco, Eduardo A. Robleto, Mario Pedraza-Reyes
The guanine oxidized (GO) system of Bacillus subtilis, composed of the YtkD (MutT), MutM and MutY proteins, counteracts the cytotoxic and genotoxic effects of the oxidized nucleobase 8-OxoG. Here, we report that in growing B. subtilis cells, the genetic inactivation of GO system potentiated mutagenesis (HPM), and subsequent hyperresistance, contributes to the damaging effects of hydrogen peroxide (H2O2)
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Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases Antioxidants (IF 7.0) Pub Date : 2024-03-07 Abraham Alberto Ramírez-Mendoza, María Luisa Mendoza-Magaña, Mario Alberto Ramírez-Herrera, Zamira Helena Hernández-Nazara, José Alfredo Domínguez-Rosales
Millions of people around the world are exposed to air pollutants, such as particulate matter 2.5 (PM2.5) and ozone (O3). Such exposure usually does not exclude these two types of pollutants and their harmful effects could be additive or synergistic. O3 is a highly oxidizing gas that reacts with the cellular environment just as PM2.5, triggering nitrooxidative damage. Once nitrooxidative stress overcomes
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Induction of Neuroinflammation and Brain Oxidative Stress by Brain-Derived Extracellular Vesicles from Hypertensive Rats Antioxidants (IF 7.0) Pub Date : 2024-03-07 Xinqian Chen, Xin Yan, Leah Gingerich, Qing-Hui Chen, Lanrong Bi, Zhiying Shan
Neuroinflammation and brain oxidative stress are recognized as significant contributors to hypertension including salt sensitive hypertension. Extracellular vesicles (EVs) play an essential role in intercellular communication in various situations, including physiological and pathological ones. Based on this evidence, we hypothesized that EVs derived from the brains of hypertensive rats with salt sensitivity
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Lercanidipine’s Antioxidative Effect Prevents Noise-Induced Hearing Loss Antioxidants (IF 7.0) Pub Date : 2024-03-07 Zhaoqi Guo, E Tian, Sen Chen, Jun Wang, Jingyu Chen, Weijia Kong, Debbie C. Crans, Yisheng Lu, Sulin Zhang
Noise-induced hearing loss (NIHL) is a prevalent form of adult hearing impairment, characterized by oxidative damage to auditory sensory hair cells. Although certain dihydropyridines, the L-type calcium channel blockers, exhibit protective properties against such damage, the ability of third-generation dihydropryidines like lercanidipine to mitigate NIHL remains unclear.We utilized glucose oxidase
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Roles of Traditional and Next-Generation Probiotics on Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review and Network Meta-Analysis Antioxidants (IF 7.0) Pub Date : 2024-03-07 Yuezhi Zhu, Jen Kit Tan, Jia Liu, Jo Aan Goon
Non-alcoholic fatty liver disease (NAFLD) and its progressive stage, non-alcoholic steatohepatitis (NASH), are becoming one of the most common chronic liver diseases globally. Lifestyle interventions such as weight reduction, increased physical activity, and maintaining healthy diets play a pivotal role in managing NAFLD/NASH. Recent studies suggest that the gut microbiome is associated with the pathogenesis
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Multifaceted Effects of L-Cysteine, L-Ascorbic Acid, and Their Derivatives on the Viability and Melanin Synthesis of B16/F10 Cells under Different Conditions Antioxidants (IF 7.0) Pub Date : 2024-03-07 Joon Yong Choi, Jae Won Ha, Yong Chool Boo
The total melanin synthesis in the skin depends on various melanogenic factors, including the number of viable melanocytes, the level of melanogenic enzymes per cell, and the reaction rate of the enzymes. The purpose of this study is to examine the effects of L-cysteine (L-Cys), L-ascorbic acid (L-AA), and their derivatives on the tyrosinase (TYR) activity and autoxidation of L-3,4-dihydroxyphenylalanine
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Exosomal Dynamics and Brain Redox Imbalance: Implications in Alzheimer’s Disease Pathology and Diagnosis Antioxidants (IF 7.0) Pub Date : 2024-03-05 Aritri Bir, Arindam Ghosh, Aman Chauhan, Sarama Saha, Adesh K. Saini, Marco Bisaglia, Sasanka Chakrabarti
Oxidative burden plays a central role in Alzheimer’s disease (AD) pathology, fostering protein aggregation, inflammation, mitochondrial impairment, and cellular dysfunction that collectively lead to neuronal injury. The role of exosomes in propagating the pathology of neurodegenerative diseases including AD is now well established. However, recent studies have also shown that exosomes are crucial responders
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Strain-Specific Benefits of Bacillus on Growth, Intestinal Health, Immune Modulation, and Ammonia-Nitrogen Stress Resilience in Hybrid Grouper Antioxidants (IF 7.0) Pub Date : 2024-03-06 Congjie Han, Huizhong Shi, Congcong Cui, Jiawen Wang, Ling Li, Weilie Bei, Yan Cai, Shifeng Wang
In the dynamic field of intensive aquaculture, the strategic application of probiotics has become increasingly crucial, particularly for enhancing resistance to environmental stressors such as ammonia-nitrogen. Over a 42-day period, this study investigated the effects of different probiotic strains—Bacillus subtilis (BS, 6-3-1, and HAINUP40)—on the health and resilience of hybrid groupers. Each strain
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Higher Plant-Derived Biostimulants: Mechanisms of Action and Their Role in Mitigating Plant Abiotic Stress Antioxidants (IF 7.0) Pub Date : 2024-03-06 Sara Esperanza Martínez-Lorente, José Manuel Martí-Guillén, María Ángeles Pedreño, Lorena Almagro, Ana Belén Sabater-Jara
Modern agriculture is being challenged by deteriorating edaphoclimatic conditions and increasing anthropogenic pressure. This necessitates the development of innovative crop production systems that can sustainably meet the demands of a growing world population while minimizing the environmental impact. The use of plant biostimulants is gaining ground as a safe and ecologically sound approach to improving
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Effects of Dietary Eucommia ulmoides Leaf Extract Supplementation on Growth Performance, Meat Quality, Antioxidant Capacity, and Lipid Metabolism of Finishing Pigs Antioxidants (IF 7.0) Pub Date : 2024-03-06 Mengmeng Han, Yunju Yin, Saiming Gong, Hanjing Shi, Qilong Li, Xiao Lian, Yehui Duan, Fengna Li, Qiuping Guo
This study aimed to investigate the effects of dietary Eucommia ulmoides leaf extract (ELE) on meat quality, antioxidant capacity, and lipid metabolism in finishing pigs. A total of 240 “Duroc × Landrace × Yorkshire” crossbred pigs with an initial weight of 74.70 ± 0.77 kg were randomly assigned to two groups: control group and 0.2% ELE group, with each group containing 10 replicates of 12 pigs per
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The Efficacy and Safety of GF101 and Its Antioxidant Effect on In Vitro Fertilization Outcomes: A Double-Blind, Non-Inferiority, Randomized, Controlled Trial with Coenzyme Q10 Antioxidants (IF 7.0) Pub Date : 2024-03-06 So Yeon Shin, Hye Kyung Yoon, Jee Hyun Kim, Ji Hyang Kim, Chan Park, Dong Hee Choi, Young Dong Yu, Ji Eun Shin, Hwang Kwon
(1) Background: Oxidative stress adversely affects fertility by impairing oocyte fertilization potential, primarily due to meiotic segregation errors and cohesion loss. Superoxide dismutase (SOD) and Coenzyme Q10 (CoQ10) are prominent antioxidants known to mitigate oxidative damage. (2) Methods: This study recruited 86 patients undergoing in vitro fertilization (IVF) at a single center for a 12-week
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Impact of Seminal Plasma Antioxidants on DNA Fragmentation and Lipid Peroxidation of Frozen–Thawed Horse Sperm Antioxidants (IF 7.0) Pub Date : 2024-03-06 Jaime Catalán, Iván Yánez-Ortiz, Marc Torres-Garrido, Jordi Ribas-Maynou, Marc Llavanera, Isabel Barranco, Marc Yeste, Jordi Miró
Cryopreservation is a stressful process for sperm, as it is associated with an increased production of reactive oxygen species (ROS). Elevated ROS levels, which create an imbalance with antioxidant capacity, may result in membrane lipid peroxidation (LPO), protein damage and DNA fragmentation. This study aimed to determine whether the membrane LPO and DNA fragmentation of frozen–thawed horse sperm
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Hydrogen Sulfide Alleviates Oxidative Damage under Chilling Stress through Mitogen-Activated Protein Kinase in Tomato Antioxidants (IF 7.0) Pub Date : 2024-03-06 Guoxiu Wu, Xuxu Niu, Jiahui Chen, Changjiang Wu, Yang Li, Yanman Li, Dandan Cui, Xueying He, Fan Wang, Shengli Li
Tomato is the vegetable with the largest greenhouse area in China, and low temperature is one of the main factors affecting tomato growth, yield, and quality. Hydrogen sulfide (H2S) plays an important role in regulating plant chilling tolerance, but its downstream cascade reaction and mechanism remain unclear. Mitogen-activated protein kinases (MAPK/MPKs) are closely related to a variety of signaling
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Silybin Alleviated Hepatic Injury by Regulating Redox Balance, Inflammatory Response, and Mitochondrial Function in Weaned Piglets under Paraquat-Induced Oxidative Stress Antioxidants (IF 7.0) Pub Date : 2024-03-06 Long Cai, Dongxu Ming, Wenning Chen, Ying Zhao, Yanpin Li, Wenjuan Sun, Yu Pi, Xianren Jiang, Xilong Li
Silybin (Si) is the main element of silymarin isolated from the seeds of Silybum marianum L. Gaernt., which has superior antioxidant properties. However, the protective role of Si in maintaining liver health under oxidative stress remains ambiguous. This study aimed to investigate the underlying mechanism of the beneficial effect of dietary Si against hepatic oxidative injury induced by paraquat (PQ)
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Characterization of Azorean Plant Leaves for Sustainable Valorization and Future Advanced Applications in the Food, Cosmetic, and Pharmaceutical Industries Antioxidants (IF 7.0) Pub Date : 2024-03-06 Jorge Gomes Lopes Barros, Raquel Fernandes, Ana Abraão, Rui Dias Costa, Alfredo Aires, Irene Gouvinhas, Daniel Granato, Ana Novo Barros
The historical use of plants as sources of natural compounds has persisted over time. Increasing the intake of bioactive substances shows significant potential for promoting overall well-being and health. This study delves into the pigments, phenolic composition, and profile, along with antioxidant properties, of leaf extracts rich in bioactives from plants in the Azores region, contributing to sustainable
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Assessment of Six Blackberry Cultivars Using a Combination of Metabolomics, Biological Activity, and Network Pharmacology Approaches Antioxidants (IF 7.0) Pub Date : 2024-03-06 Hana Lee, Zhixin Wang, Zhanao Deng, Yu Wang
Blackberries have gained considerable attention due to their high antioxidant content and potential health benefits. This study compared the metabolite profiles of six blackberry cultivars and investigated their biological activities. The metabolites extracted from blackberries were analyzed using metabolomics, and their biological activities and mechanisms were confirmed using in vitro models and
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Complex Formation between the Transcription Factor WRKY53 and Antioxidative Enzymes Leads to Reciprocal Inhibition Antioxidants (IF 7.0) Pub Date : 2024-03-05 Ana Gabriela Andrade Galan, Jasmin Doll, Natalie Faiß, Patricia Weber, Ulrike Zentgraf
The transcription factor WRKY53 of the model plant Arabidopsis thaliana is an important regulator of leaf senescence. Its expression, activity and degradation are tightly controlled by various mechanisms and feedback loops. Hydrogen peroxide is one of the inducing agents for WRKY53 expression, and a long-lasting intracellular increase in H2O2 content accompanies the upregulation of WRKY53 at the onset
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Effects of Ferulic Acid on Respiratory Metabolism, Oxidative Lesions, and Apoptotic Parameters in Gills and Red Blood Cells of Carp (Cyprinus carpio Var. Jian) Response to Copper Antioxidants (IF 7.0) Pub Date : 2024-03-04 Huatao Li, Haijing Liu, Siyue Wu, Chengyan Ai, Qi Yang, Jingting Jia, Xiao Xu, Min Wu, Jun Jiang
In sustainable aquaculture systems, copper sulfate (CuSO4) is widely applied as a disinfectant to control parasitic infections and algal growth. However, aquatic organisms may suffer from exposure to excessive concentrations of Cu. Elevated Cu concentrations could activate damage to the respiratory functions of aquatic animals. Thus, this study explored the effects exerted by ferulic acid (FA) on respiratory
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Lipoxygenase LOX3 Is the Enigmatic Tocopherol Oxidase in Runner Bean (Phaseolus coccineus) Antioxidants (IF 7.0) Pub Date : 2024-02-29 Jerzy Kruk, Paweł Jedynak, Sylwia Kędracka-Krok, Renata Szymańska, Michał Gabruk
Purification of extracts from the etiolated seedlings of runner bean (Phaseolus coccineus), coupled with mass spectrometry analysis of proteins revealed that the enzyme responsible for tocopherol oxidation activity is lipoxygenase, an enzyme known for enzymatic lipid peroxidation of unsaturated lipids. Biochemical analysis of the activity, along with the expression profile of three LOX isoforms (LOX1
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Supercritical Fluid Extraction of Bioactive Components from Apple Peels and Their Modulation of Complex I Activity in Isolated Mitochondria Antioxidants (IF 7.0) Pub Date : 2024-03-01 Antonella Aresta, Nicoletta De Vietro, Pietro Cotugno, Ciro Leonardo Pierri, Lucia Trisolini, Carlo Zambonin
Supercritical fluid extraction (SFE) was used to extract bioactive compounds from apple (Malus domestica) peel waste from three different Italian cultivars. The bioactive fractions were extracted applying a temperature of 60 °C and a pressure of 250 bar for 15 min with 20% ethanol as co-solvent, at a flow rate of 2 mL/min. The total polyphenol (TP), anthocyanin (TA), ascorbic acid (AA), and antioxidant
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Health Benefits of Electrolyzed Hydrogen Water: Antioxidant and Anti-Inflammatory Effects in Living Organisms Antioxidants (IF 7.0) Pub Date : 2024-03-02 Di Hu, Shigeru Kabayama, Yasuyoshi Watanabe, Yilong Cui
Molecular hydrogen, the smallest and lightest molecule, serves as an intense reducing agent. Its distinct characteristics, including minimal size and neutral charge, enhance bioavailability and facilitate significant biological effects. Previously considered physiologically inert, hydrogen has gained recognition as a powerful therapeutic agent, known for its antioxidative and anti-inflammatory properties
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Mitochondria-Targeted Antioxidant Therapeutics for Traumatic Brain Injury Antioxidants (IF 7.0) Pub Date : 2024-02-29 Hiren R. Modi, Sudeep Musyaju, Meaghan Ratcliffe, Deborah A. Shear, Anke H. Scultetus, Jignesh D. Pandya
Traumatic brain injury (TBI) is a major global health problem that affects both civilian and military populations worldwide. Post-injury acute, sub-acute, and chronic progression of secondary injury processes may contribute further to other neurodegenerative diseases. However, there are no approved therapeutic options available that can attenuate TBI-related progressive pathophysiology. Recent advances
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Correction: Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an Achillea millefolium L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against Helicobacter pylori. Antioxidants 2022, 11, 1849 Antioxidants (IF 7.0) Pub Date : 2024-02-29 Marisol Villalva, Jose Manuel Silvan, Teresa Alarcón-Cavero, David Villanueva-Bermejo, Laura Jaime, Susana Santoyo, Adolfo J. Martinez-Rodriguez
Table S1 in the Supplementary Material (Phenolic compounds identified in yarrow samples by using HPLC-ESI-QTOF-MS) in the original paper [...]
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TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo Antioxidants (IF 7.0) Pub Date : 2024-03-01 Chong Zhou, Dandan Li, Jinxia He, Tao Luo, Yiting Liu, Yue Xue, Jian Huang, Liping Zheng, Jia Li
Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by the abnormal alteration of hormone levels such as FSH and E2. POI causes infertility, severe daily life disturbances, and long-term health risks. However, the underlying mechanism remains largely unknown. In this study, we found that POI is associated with the cellular senescence of ovarian granulosa
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DPPH Measurements and Structure—Activity Relationship Studies on the Antioxidant Capacity of Phenols Antioxidants (IF 7.0) Pub Date : 2024-03-01 Moeka Yamauchi, Yukino Kitamura, Haruka Nagano, Junya Kawatsu, Hiroaki Gotoh
The consumption of foods that are high in antioxidant capacity is believed to contribute to good health. Moreover, the addition of highly antioxidant compounds to foods is believed to prevent food deterioration. Among the known antioxidants in food, phenols have been identified as the primary antioxidants. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay is a simple, inexpensive, and rapid method widely
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Ginsenosides Rg1 and Rg2 Activate Autophagy and Attenuate Oxidative Stress in Neuroblastoma Cells Overexpressing Aβ(1-42) Antioxidants (IF 7.0) Pub Date : 2024-03-01 Ziqi Liu, Valentina Cecarini, Massimiliano Cuccioloni, Laura Bonfili, Chunmei Gong, Mauro Angeletti, Anna Maria Eleuteri
Alzheimer’s disease is a neurodegeneration with protein deposits, altered proteolysis, and inflammatory and oxidative processes as major hallmarks. Despite the continuous search for potential therapeutic treatments, no cure is available to date. The use of natural molecules as adjuvants in the treatment of Alzheimer’s disease is a very promising strategy. In this regard, ginsenosides from ginseng root
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Anti-Inflammatory Effects of Anthocyanin-Enriched Black Soybean Seed Coat (BSSC) Crude Extract on LPS-Induced Acute Liver Injury in Mice Antioxidants (IF 7.0) Pub Date : 2024-03-01 Yu-Tang Tung, Chun-Liang Tung, Cheng-Chia Hsieh, Yu-Chen Huang, Shiming Li, Chun-Liang Tung, Jyh-Horng Wu
Soybeans rank among the top five globally produced crops. Black soybeans contain anthocyanins in their seed coat, offering strong antioxidant and anti-inflammatory benefits. This study explores the protective effects of black soybean seed coat (BSSC) against acute liver injury (ALI) in mice. Mice pretreated with BSSC crude extract showed reduced liver damage, inflammation, and apoptosis. High doses
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Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution Antioxidants (IF 7.0) Pub Date : 2024-03-01 Yuhang Hong, Alessandra Boiti, Daniela Vallone, Nicholas S. Foulkes
Since the evolution of the aerobic metabolism, reactive oxygen species (ROS) have represented significant challenges to diverse life forms. In recent decades, increasing knowledge has revealed a dual role for ROS in cell physiology, showing they serve as a major source of cellular damage while also functioning as important signaling molecules in various biological processes. Our understanding of ROS
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Antioxidant Activity of Essential Oils from Pinaceae Species Antioxidants (IF 7.0) Pub Date : 2024-02-26 Robert Ancuceanu, Adriana Iuliana Anghel, Marilena Viorica Hovaneț, Anne-Marie Ciobanu, Beatrice Elena Lascu, Mihaela Dinu
With a widespread distribution throughout the Northern Hemisphere and 11 genera, Pinaceae is the largest family of Gymnosperms in the world. Essential oils are an important chemotaxonomic marker for the species of this family, although the degree of chemical and biological investigation has not been the same for all genera. Essential oils from Abies and Cedrus (from the abietoid clade) or Pinus and
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Enhancing Antioxidant and Antimicrobial Activities in Bee-Collected Pollen through Solid-State Fermentation: A Comparative Analysis of Bioactive Compounds Antioxidants (IF 7.0) Pub Date : 2024-02-27 Adriana Cristina Urcan, Adriana Dalila Criste, Daniel Severus Dezmirean, Otilia Bobiș, Victorița Bonta, Ramona Flavia Burtescu, Neli-Kinga Olah, Mihaiela Cornea-Cipcigan, Rodica Mărgăoan
The present study investigates the impact of solid-state fermentation on bee-collected pollen using a consortium of Lactobacillus plantarum, Apilactobacillus kunkeei, and Lactobacillus acidophilus. Another aim is to compare the nutritional and bioactive properties of natural versus fermented pollen, focusing on macronutrient composition, pH, acidity, lactic acid content, and profiles of polyphenolics
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A Novel Model for Evaluating the Natural Antioxidant Carnosic Acid to Improve the Stability of Rapeseed Oil in the Thermal Degradation Antioxidants (IF 7.0) Pub Date : 2024-02-28 Yingdan Zhu, Chengliang Chai, Yalin Xue, Yong Wang, Zhangqun Duan
The quality and stability of oil during thermal processing reflect the reactions in vegetable oil. The deterioration of the oil is close to the viscosity, fatty acid composition (FA), total polar compounds (TPC), etc. Carnosic acid (CA) is the main antioxidant component of rosemary extract; it is a natural and clean-label antioxidant that is allowed to be added to prolong oil processing and storage
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Suppressing the Substance P-NK1R Signalling Protects Mice against Sepsis-Associated Acute Inflammatory Injury and Ferroptosis in the Liver and Lungs Antioxidants (IF 7.0) Pub Date : 2024-02-29 Zhixing Zhu, Stephen Chambers, Madhav Bhatia
Substance P (SP), encoded by the TAC1/Tac1 gene, acts as a significant mediator in dysregulated systemic inflammatory response and associated organ injury in sepsis by activating the neurokinin-1 receptor (NK1R). This study investigated the impact of SP-NK1R signaling on ferroptosis in the liver and lungs of mice with sepsis. Sepsis was induced by caecal ligation puncture (CLP) surgery in mice. The
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Effect of a Very Low-Calorie Diet on Oxidative Stress, Inflammatory and Metabolomic Profile in Metabolically Healthy and Unhealthy Obese Subjects Antioxidants (IF 7.0) Pub Date : 2024-02-29 Neus Bosch-Sierra, Carmen Grau-del Valle, Christian Salom, Begoña Zaragoza-Villena, Laura Perea-Galera, Rosa Falcón-Tapiador, Susana Rovira-Llopis, Carlos Morillas, Daniel Monleón, Celia Bañuls
The purpose of the study was to determine the impact of weight loss through calorie restriction on metabolic profile, and inflammatory and oxidative stress parameters in metabolically healthy (MHO) and unhealthy (MUHO) obese individuals. A total of 74 subjects (34 MHO and 40 MUHO) received two cycles of a very low-calorie diet, alternating with a hypocaloric diet for 24 weeks. Biochemical, oxidative
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Dietary Polyphenols Support Akkermansia muciniphila Growth via Mediation of the Gastrointestinal Redox Environment Antioxidants (IF 7.0) Pub Date : 2024-02-29 Charlene B. Van Buiten, Valerie A. Seitz, Jessica L. Metcalf, Ilya Raskin
Obesity and metabolic dysfunction have been shown to be associated with overproduction of reactive oxygen species (ROS) in the gastrointestinal (GI) tract, which contributes to dysbiosis or imbalances in the gut microbiota. Recently, the reversal of dysbiosis has been observed as a result of dietary supplementation with antioxidative compounds including polyphenols. Likewise, dietary polyphenols have
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The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals Antioxidants (IF 7.0) Pub Date : 2024-02-29 Xiao Lian, Mingyu Shi, Ying Liang, Qinlu Lin, Lingyu Zhang
Unconventional feed, which is abundant in China, contains anti-nutritional factors and toxins; however, these can be greatly reduced with microbial fermentation, thus improving the nutrient content of the feed, enhancing animal appetites, and ultimately significantly improving the intestinal health and growth performance of animals. When oxidative stress occurs, fermented feed can effectively reduce