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  • Coronavirus interactions with the cellular autophagy machinery
    Autophagy (IF 9.77) Pub Date : 2020-09-23
    Katelyn Miller; Marisa E. McGrath; Zhiqiang Hu; Sohha Ariannejad; Stuart Weston; Matthew Frieman; William T Jackson

    The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is the most recent example of an emergent coronavirus that poses a significant threat to human health. Virus-host interactions play a major role in the viral life cycle and disease pathogenesis, and cellular pathways such as macroautophagy/autophagy prove to be either detrimental or beneficial to viral replication and maturation. Here, we describe

    更新日期:2020-09-23
  • RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein
    Autophagy (IF 9.77) Pub Date : 2020-09-22
    Supansa Pantoom; Georgios Konstantinidis; Stephanie Voss; Hongmei Han; Oliver Hofnagel; Zhiyu Li; Yao-Wen Wu

    Autophagosome formation is a fundamental process in macroautophagy/autophagy, a conserved self-eating mechanism in all eukaryotes, which requires the conjugating ATG (autophagy related) protein complex, ATG12–ATG5-ATG16L1 and lipidated MAP1LC3/LC3 (microtubule associated protein 1 light chain 3). How the ATG12–ATG5-ATG16L1 complex is recruited to membranes is not fully understood. Here, we demonstrated

    更新日期:2020-09-23
  • Next steps in mechanisms of inflammaging
    Autophagy (IF 9.77) Pub Date : 2020-09-22
    Leena P. Bharath; Barbara S. Nikolajczyk

    Striking age-related changes occur in the human immune system, beginning in the sixth decade of life. Age is a non-modifiable, universal risk factor that results in the dysregulation of many cellular homeostatic processes. The decline in immune cell macroautophagy/autophagy and the increased generation of proinflammatory cytokines during agingfuels the development of diseases in the elderly. We reported

    更新日期:2020-09-23
  • Retromer regulates the lysosomal clearance of MAPT/tau
    Autophagy (IF 9.77) Pub Date : 2020-09-22
    Julian M. Carosi; Leanne K. Hein; Mark van den Hurk; Robert Adams; Bridget Milky; Sanjna Singh; Cedric Bardy; Donna Denton; Sharad Kumar; Timothy J. Sargeant

    The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset neurological disorders including Alzheimer disease. Spatial overlap between depletion of the endosomal-sorting complex

    更新日期:2020-09-23
  • Proteasome malfunction activates the PPP3/calcineurin-TFEB-SQSTM1/p62 pathway to induce macroautophagy in the heart
    Autophagy (IF 9.77) Pub Date : 2020-09-22
    Huabo Su; Xuejun Wang

    Proteasome inhibition (PSMI) is known to activate macroautophagy (autophagy hereafter), but the underlying mechanisms remain to be fully delineated. Here we discuss our recent work identifying an important PPP3/calcineurin-TFEB-SQSTM1/p62 pathway in mediating activation of autophagy by PSMI, a compensatory process for the heart with proteasome malfunction. Through increasing PPP3/calcineurin activity

    更新日期:2020-09-23
  • Fluid flow-induced shear stress controls the metabolism of proximal tubule kidney epithelial cells through primary cilium-dependent lipophagy and mitochondrial biogenesis
    Autophagy (IF 9.77) Pub Date : 2020-09-20
    Caterina Miceli; Federica Roccio; Lucille Penalva-Mousset; Etienne Morel; Patrice Codogno; Nicolas Dupont

    The kidney, similar to many other organs, has to face shear stress induced by biological fluids. How epithelial kidney cells respond to shear stress is poorly understood. Recently we showed in vitro and in vivo that proximal tubule epithelial cells use lipophagy to fuel mitochondria with fatty acids. Lipophagy is stimulated by a primary cilium-dependent signaling that converges at AMP kinase. AMP kinase

    更新日期:2020-09-20
  • Neutrophil autophagy during human active tuberculosis is modulated by SLAMF1
    Autophagy (IF 9.77) Pub Date : 2020-09-20
    Joaquín Miguel Pellegrini; Florencia Sabbione; María Paula Morelli; Nancy Liliana Tateosian; Florencia Andrea Castello; Nicolás Oscar Amiano; Domingo Palmero; Alberto Levi; Lorena Ciallella; María Isabel Colombo; Analía Silvina Trevani; Verónica Edith García

    Neutrophils infected with Mycobacterium tuberculosis (Mtb) predominate in tuberculosis patients’ lungs. Neutrophils phagocytose the pathogen, but the mechanism of pathogen elimination is controversial. Macroautophagy/autophagy, a crucial mechanism for several neutrophil functions, can be modulated by immunological mediators. The costimulatory molecule SLAMF1 can act as a microbial sensor in macrophages

    更新日期:2020-09-20
  • Corrigendum: Engagement of Circular RNA HECW2 in the Nonautophagic Role of ATG5 Implicated in the Endothelial-Mesenchymal Transition
    Autophagy (IF 9.77) Pub Date : 2020-09-18

    (2020). Corrigendum: Engagement of Circular RNA HECW2 in the Nonautophagic Role of ATG5 Implicated in the Endothelial-Mesenchymal Transition. Autophagy. Ahead of Print.

    更新日期:2020-09-20
  • Corrigendum for miR-143/BBC
    Autophagy (IF 9.77) Pub Date : 2020-09-16

    (2020). Corrigendum for miR-143/BBC. Autophagy. Ahead of Print.

    更新日期:2020-09-16
  • Corrigendum for circHIPK2
    Autophagy (IF 9.77) Pub Date : 2020-09-16

    (2020). Corrigendum for circHIPK2. Autophagy. Ahead of Print.

    更新日期:2020-09-16
  • Zika virus NS2A protein induces the degradation of KPNA2 (karyopherin subunit alpha 2) via chaperone-mediated autophagy
    Autophagy (IF 9.77) Pub Date : 2020-09-14
    Jia He; Liping Yang; Peixi Chang; Shixing Yang; Shaoli Lin; Qiyi Tang; Xinping Wang; Yan-Jin Zhang

    KPNA2/importin-alpha1 (karyopherin subunit alpha 2) is the primary nucleocytoplasmic transporter for some transcription factors to activate cellular proliferation and differentiation. Aberrant increase of KPNA2 level is identified as a prognostic marker in a variety of cancers. Yet, the turnover mechanism of KPNA2 remains unknown. Here, we demonstrate that KPNA2 is degraded via the chaperone-mediated

    更新日期:2020-09-14
  • LDHB inhibition induces mitophagy and facilitates the progression of CSFV infection
    Autophagy (IF 9.77) Pub Date : 2020-09-14
    Shuangqi Fan; Keke Wu; Mingqiu Zhao; Jin Yuan; Shengming Ma; Ereng Zhu; Yuming Chen; Hongxing Ding; Lin Yi; Jinding Chen

    Cellular metabolism caters to the energy and metabolite needs of cells. Although the role of the terminal metabolic enzyme LDHB (lactate dehydrogenase B) in the glycolysis pathway has been widely studied in cancer cells, its role in viral infection is relatively unknown. In this study, we found that CSFV (classical swine fever virus) infection reduces pyruvate levels while promotes lactate release

    更新日期:2020-09-14
  • New Insights Regarding SNARE Proteins in Autophagosome-Lysosome Fusion
    Autophagy (IF 9.77) Pub Date : 2020-09-14
    Xiaoyu Tian; Junlin Teng; Jianguo Chen

    Macroautophagy/autophagy refers to the engulfment of cellular contents selected for lysosomal degradation. The final step in autophagy is the fusion of autophagosome with the lysosome, which is mediated by SNARE proteins. Of the SNAREs, autophagosome-localized Q-SNAREs, such as STX17 and SNAP29, and lysosome-localized R-SNAREs, such as VAMP8 or VAMP7, have been reported to be involved. Recent studies

    更新日期:2020-09-14
  • The Role of Autophagy in Targeted Therapy for Acute Myeloid Leukemia
    Autophagy (IF 9.77) Pub Date : 2020-09-11
    Wenxin Du; Aixiao Xu; Yunpeng Huang; Ji Cao; Hong Zhu; Bo Yang; Xuejing Shao; Qiaojun He; Meidan Ying

    Although molecular targeted therapies have recently displayed therapeutic effects in acute myeloid leukemia (AML), limited response and acquired resistance remain common problems. Numerous studies have associated autophagy, an essential degradation process involved in the cellular response to stress, with the development and therapeutic response of cancers including AML. Thus, we review studies on

    更新日期:2020-09-12
  • Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation
    Autophagy (IF 9.77) Pub Date : 2020-09-11
    Sumit Kumar; Ravikanth Nanduri; Ella Bhagyaraj; Rashi Kalra; Nancy Ahuja; Anuja P. Chacko; Drishti Tiwari; Kanupriya Sethi; Ankita Saini; Vemika Chandra; Monika Jain; Shalini Gupta; Deepak Bhatt; Pawan Gupta

    Macrophage derived foam cells in atherosclerotic plaques are the major factor responsible for the pathogenesis of atherosclerosis (AS). During advanced AS, macrophage-specific macroautophagy/autophagy is dysfunctional. 1, 25-dihydroxy vitamin D3 (VitD3) and its receptor VDR (vitamin D receptor) are reported to inhibit foam cell formation and induce autophagy; however, the role of VitD3-VDR-induced

    更新日期:2020-09-12
  • Autophagy Controls Mesenchymal Stem Cell Therapy in Psychological Stress Colitis Mice
    Autophagy (IF 9.77) Pub Date : 2020-09-10
    Jun Tian; Xiaoxing Kou; Runci Wang; Huan Jing; Chider Chen; Jianxia Tang; Xueli Mao; Bingjiao Zhao; Xi Wei; Songtao Shi

    Mesenchymal stem cell transplantation (MSCT) has been applied to treat a variety of autoimmune and inflammatory diseases. Psychosocial stress can aggravate disease progression in chronic inflammatory patients. Whether psychological stress affects MSCT is largely unknown. In this study we show that psychological stress attenuates therapeutic effects of MSCT in a DSS-induced colitis mouse model by elevating

    更新日期:2020-09-11
  • TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells
    Autophagy (IF 9.77) Pub Date : 2020-09-10
    Tobit D. Steinmetz; Ursula Schlötzer-Schrehardt; Abigail Hearne; Wolfgang Schuh; Jens Wittner; Sebastian R. Schulz; Thomas H. Winkler; Hans-Martin Jäck; Dirk Mielenz

    Plasma cells depend on quality control of newly synthesized antibodies in the endoplasmic reticulum (ER) via macroautophagy/autophagy and proteasomal degradation. The cytosolic adaptor protein TFG (Trk-fused gene) regulates ER-Golgi transport, the secretory pathway and proteasome activity in non-immune cells. We show here that TFG is upregulated during lipopolysaccharide- and CpG-induced differentiation

    更新日期:2020-09-11
  • An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells
    Autophagy (IF 9.77) Pub Date : 2020-09-08
    Nicholas Ariotti; Yeping Wu; Satomi Okano; Yann Gambin; Jordan Follett; James Rae; Charles Ferguson; Rohan D. Teasdale; Kirill Alexandrov; Frederic A. Meunier; Michelle M. Hill; Robert G. Parton

    CAV1 (caveolin 1) expression and secretion is associated with prostate cancer (PCa) disease progression, but the mechanisms underpinning CAV1 release remain poorly understood. Numerous studies have shown CAV1 can be secreted within exosome-like vesicles, but antibody-mediated neutralization can mitigate PCa progression; this is suggestive of an inverted (non-exosomal) CAV1 topology. Here we show that

    更新日期:2020-09-08
  • Beth Levine in memoriam.
    Autophagy (IF 9.77) Pub Date : 2020-07-29

    (2020). Beth Levine in memoriam. Autophagy: Vol. 16, No. 9, pp. 1559-1583.

    更新日期:2020-09-08
  • A nuclear role for Atg8-family proteins.
    Autophagy (IF 9.77) Pub Date : 2020-07-18
    Anne-Claire Jacomin,Stavroula Petridi,Marisa Di Monaco,Ioannis P Nezis

    Despite the growing evidence that the macroautophagy/autophagy-related protein LC3 is localized in the nucleus, why and how it is targeted to the nucleus are poorly understood. In our recent study, we found that transcription factor seq (sequoia) interacts via its LIR motif with Atg8a, the Drosophila homolog of LC3, to negatively regulate the transcription of autophagy genes. Atg8a was found to also

    更新日期:2020-09-08
  • The CCNY (cyclin Y)-CDK16 kinase complex: a new regulator of autophagy downstream of AMPK.
    Autophagy (IF 9.77) Pub Date : 2020-07-29
    Jörg Vervoorts,Dietbert Neumann,Bernhard Lüscher

    (2020). The CCNY (cyclin Y)-CDK16 kinase complex: a new regulator of autophagy downstream of AMPK. Autophagy: Vol. 16, No. 9, pp. 1724-1726.

    更新日期:2020-09-08
  • Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.
    Autophagy (IF 9.77) Pub Date : 2020-07-27
    Anyuan He,John M Dean,Dongliang Lu,Yali Chen,Irfan J Lodhi

    Hepatic lipid homeostasis is controlled by a coordinated regulation of various metabolic pathways involved in de novo synthesis, uptake, storage, and catabolism of lipids. Disruption of this balance could lead to hepatic steatosis. Peroxisomes play an essential role in lipid metabolism, yet their importance is often overlooked. In a recent study, we demonstrated a role for hepatic peroxisomal β-oxidation

    更新日期:2020-09-08
  • CALCOCO1 is a soluble reticulophagy receptor.
    Autophagy (IF 9.77) Pub Date : 2020-07-25
    Thaddaeus Mutugi Nthiga,Birendra Kumar Shrestha,Trond Lamark,Terje Johansen

    The endoplasmic reticulum (ER) is the largest membrane-bound organelle in eukaryotic cells and plays critical roles in diverse processes in metabolism, signaling and intracellular organization. In response to stress stimuli such as nutrient deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through upregulated synthesis of its components to counteract

    更新日期:2020-09-08
  • BSN (bassoon) and PRKN/parkin in concert control presynaptic vesicle autophagy.
    Autophagy (IF 9.77) Pub Date : 2020-08-10
    Carolina Montenegro-Venegas,Anil Annamneedi,Sheila Hoffmann-Conaway,Eckart D Gundelfinger,Craig C Garner

    Maintaining the integrity and function of the presynaptic neurotransmitter release apparatus is a demanding process for a post-mitotic neuron; the mechanisms behind it are still unclear. BSN (bassoon), an active zone scaffolding protein, has been implicated in the control of presynaptic macroautophagy/autophagy, a process we recently showed depends on poly-ubiquitination of synaptic proteins. Moreover

    更新日期:2020-09-08
  • Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy.
    Autophagy (IF 9.77) Pub Date : 2020-09-07
    Koji Yamano,Richard J Youle

    PINK1 and PRKN, proteins mutated in Parkinson disease, selectively amplify ubiquitin signals on damaged mitochondria for elimination via mitophagy. Because all five macroautophagy/autophagy receptors in mammals possess domains binding to ubiquitin and Atg8-family proteins, they were thought to recruit Atg8-family protein labeled phagophores from a cytosolic pool. However, our recent findings show that

    更新日期:2020-09-08
  • Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34
    Autophagy (IF 9.77) Pub Date : 2020-09-05
    Bassam Janji; Meriem Hasmim; Santiago Parpal; Angelo De Milito; Guy Berchem; Muhammad Zaeem Noman

    Cancer immunotherapy based on Immune checkpoint blockade (ICB) is a promising strategy to treat patients with advanced highly aggressive therapy-resistant tumors. Unfortunately, the clinical reality is that only a small number of patients benefit from the remarkable clinical remissions achieved by ICB. Experimental and clinical evidence claimed that durable clinical benefit observed using ICB depends

    更新日期:2020-09-06
  • Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34.
    Autophagy (IF 9.77) Pub Date : 2020-09-05
    Bassam Janji,Meriem Hasmim,Santiago Parpal,Angelo De Milito,Guy Berchem,Muhammad Zaeem Noman

    Cancer immunotherapy based on Immune checkpoint blockade (ICB) is a promising strategy to treat patients with advanced highly aggressive therapy-resistant tumors. Unfortunately, the clinical reality is that only a small number of patients benefit from the remarkable clinical remissions achieved by ICB. Experimental and clinical evidence claimed that durable clinical benefit observed using ICB depends

    更新日期:2020-09-05
  • A new mechanism for autophagy regulation of anti-tumor immune responses.
    Autophagy (IF 9.77) Pub Date : 2020-09-05
    Andrew Thorburn

    In this commentary I discuss a recent paper that describes a new mechanism for how macroautophagy/autophagy regulates the immune response to cancer, and relate it to other recent studies in this area. These recent developments may allow more effective strategies to manipulate autophagy to improve cancer therapy.

    更新日期:2020-09-05
  • Epr1, a UPR-upregulated soluble autophagy receptor for reticulophagy.
    Autophagy (IF 9.77) Pub Date : 2020-09-05
    Dan Zhao,Li-Lin Du

    The endoplasmic reticulum (ER) is a major site of protein folding. Perturbations in the folding capacity of the ER result in ER stress. ER stress triggers autophagic degradation of the ER (reticulophagy). Molecular mechanisms underlying ER stress-induced reticulophagy remain largely unknown. Our recent study identified a soluble protein, Epr1, as an autophagy receptor for ER stress-induced reticulophagy

    更新日期:2020-09-05
  • PDPK1 regulates autophagosome biogenesis by binding to PIK3C3.
    Autophagy (IF 9.77) Pub Date : 2020-09-02
    Boli Hu,Yina Zhang,Tingjuan Deng,Jinyan Gu,Juan Liu,Hui Yang,Yuting Xu,Yan Yan,Fan Yang,Heng Zhang,Yulan Jin,Jiyong Zhou

    PDPK1 (3-phosphoinositide dependent protein kinase 1) is a phosphorylation-regulated kinase that plays a central role in activating multiple signaling pathways and cellular processes. Here, this study shows that PDPK1 turns on macroautophagy/autophagy as a SUMOylation-regulated kinase. In vivo data demonstrate that the SUMO modification of PDPK1 is a physiological feature in the brain and that it can

    更新日期:2020-09-02
  • The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
    Autophagy (IF 9.77) Pub Date : 2020-09-02
    Patricia González-Rodríguez,Mathilde Cheray,Jens Füllgrabe,Maria Salli,Pinelopi Engskog-Vlachos,Lily Keane,Virginia Cunha,Agata Lupa,Wenbo Li,Qi Ma,Kristian Dreij,Michael G Rosenfeld,Bertrand Joseph

    Macroautophagy/autophagy is a conserved catabolic pathway that targets cytoplasmic components for their degradation and recycling in an autophagosome-dependent lysosomal manner. Under physiological conditions, this process maintains cellular homeostasis. However, autophagy can be stimulated upon different forms of cellular stress, ranging from nutrient starvation to exposure to drugs. Thus, this pathway

    更新日期:2020-09-02
  • Keratinocyte autophagy enables the activation of keratinocytes and fibroblasts and facilitates wound healing.
    Autophagy (IF 9.77) Pub Date : 2020-08-31
    Lei Qiang,Seungwon Yang,Yan-Hong Cui,Yu-Ying He

    Macroautophagy/autophagy is a cellular catabolic process that is implicated in several physiological and pathological processes. However, the role of epidermal autophagy in wound healing remains unknown. Here, using mice with genetic ablation of the essential Atg5 (autophagy related 5) or Atg7 in their epidermis to inhibit autophagy, we show that keratinocyte autophagy regulates wound healing in mice

    更新日期:2020-08-31
  • Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial.
    Autophagy (IF 9.77) Pub Date : 2020-08-31
    Inge Compter,Danielle B P Eekers,Ann Hoeben,Kasper M A Rouschop,Bart Reymen,Linda Ackermans,Jan Beckervordersantforth,Noel J C Bauer,Monique M Anten,Pieter Wesseling,Alida A Postma,Dirk De Ruysscher,Philippe Lambin

    Treatment of glioblastoma xenografts with chloroquine results in macroautophagy/autophagy inhibition, resulting in a reduction of tumor hypoxia and sensitization to radiation. Preclinical data show that EGFRvIII-expressing glioblastoma may benefit most from chloroquine because of autophagy dependency. This study is the first to explore the safety, pharmacokinetics and maximum tolerated dose of chloroquine

    更新日期:2020-08-31
  • 1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.
    Autophagy (IF 9.77) Pub Date : 2020-08-24
    Mario A Lauterbach,Victor Saavedra,Matthew S J Mangan,Anke Penno,Christoph Thiele,Eicke Latz,Lars Kuerschner

    1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids of clinical relevance as they are elevated in plasma of patients suffering from hereditary sensory and autonomic neuropathy (HSAN1) or type 2 diabetes. Their neurotoxicity is described best but they inflict damage to various cell types by an uncertain pathomechanism. Using mouse embryonic fibroblasts and an alkyne analog of 1-deoxysphinganine

    更新日期:2020-08-26
  • Structure of human ATG9A: how holey art thou?
    Autophagy (IF 9.77) Pub Date : 2020-08-25
    Wayne D Hawkins,Daniel J Klionsky

    Several studies have provided insight into the unique intracellular localization, dynamic trafficking and diverse repertoire of binding partners of Atg9/ATG9, but structural details of the protein have remained elusive. Guardia and colleagues now report the structure of human ATG9A to a resolution of 2.9 Å, revealing, among other features, an elaborate system of tunnels permeating the ATG9A protein

    更新日期:2020-08-25
  • Autophagic protein ATG5 controls antiviral immunity via glycolytic reprogramming of dendritic cells against respiratory syncytial virus infection.
    Autophagy (IF 9.77) Pub Date : 2020-08-20
    Dong Sun Oh,Jang Hyun Park,Hi Eun Jung,Hyun-Jin Kim,Heung Kyu Lee

    Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections in infants. Macroautophagy/autophagy is a catalytic metabolic process required for cellular homeostasis. Although intracellular metabolism is important for immune responses in dendritic cells, the link between autophagy and immunometabolism remains unknown. Here, we show that the autophagy-related protein ATG5 regulates

    更新日期:2020-08-21
  • IRGM Links Autoimmunity to Autophagy.
    Autophagy (IF 9.77) Pub Date : 2020-08-19
    Parej Nath,Kautilya Kumar Jena,Subhash Mehto,Nishant Ranjan Chauhan,Rinku Sahu,Kollori Dhar,Kolapalli Srinivas,Swati Chauhan,Santosh Chauhan

    IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The abnormal activation of type I interferon (IFN) response is one of the significant factors in the pathogenesis of several autoimmune diseases. In our recent study, we showed that IRGM is a master suppressor of the interferon response. We found that

    更新日期:2020-08-20
  • Mitophagy coordination with retrograde transport ensures the integrity of synaptic mitochondria.
    Autophagy (IF 9.77) Pub Date : 2020-08-19
    Sinsuk Han,Yu Young Jeong,Preethi Sheshadri,Qian Cai

    Mitochondria sustain various essential functions at synaptic terminals. Synaptic mitochondria deficits have been implicated in early Alzheimer disease (AD) pathophysiology. Mitophagy, a selective autophagy for removal of damaged mitochondria, plays a key role in mitochondrial quality control in neurons. However, fundamental questions remain unanswered as to whether mitophagy regulates synaptic mitochondrial

    更新日期:2020-08-20
  • The roles of MAGEA6 variants in pancreatic cancer development and their potential impact on cancer immunotherapy.
    Autophagy (IF 9.77) Pub Date : 2020-08-18
    Yiu Huen Tsang,Gordon B Mills

    The melanoma-associated antigen family A (MAGEA) antigens are expressed in a wide variety of malignant tumors but not in adult somatic cells, rendering them attractive targets for cancer immunotherapy. Recent studies uncovered a role for MAGEA6 in suppression of macroautophagy/autophagy implicating MAGEA6 in tumorigenesis. The impact of cancer-associated MAGEA6 mutations on tumor pathophysiology are

    更新日期:2020-08-19
  • Ferroptosis: Machinery and Regulation
    Autophagy (IF 9.77) Pub Date : 2020-08-17
    Xin Chen; Jingbo Li; Rui Kang; Daniel J. Klionsky; Daolin Tang

    Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron-containing enzyme lipoxygenase is the main promoter of ferroptosis by producing lipid hydroperoxides, and its function relies on the activation of ACSL4-dependent lipid biosynthesis. In contrast, the selenium-containing

    更新日期:2020-08-17
  • Phosphorylation of ATG18a by BAK1 Suppresses Autophagy and Attenuates Plant Resistance against Necrotrophic Pathogens
    Autophagy (IF 9.77) Pub Date : 2020-08-17
    Bao Zhang; Lu Shao; Jiali Wang; Yan Zhang; Xiaoshuang Guo; Yujiao Peng; Yangrong Cao; Zhibing Lai

    Autophagy is critical for plant defense against necrotrophic pathogens, which causes serious yield loss on crops. However, the post-translational regulatory mechanisms of autophagy pathway in plant resistance against necrotrophs remain poorly understood. In this study, we report that phosphorylation modification on ATG18a, a key regulator of autophagosome formation in Arabidopsis thaliana, constitutes

    更新日期:2020-08-17
  • Phosphorylation of ATG18a by BAK1 suppresses autophagy and attenuates plant resistance against necrotrophic pathogens.
    Autophagy (IF 9.77) Pub Date : 2020-08-26
    Bao Zhang,Lu Shao,Jiali Wang,Yan Zhang,Xiaoshuang Guo,Yujiao Peng,Yangrong Cao,Zhibing Lai

    Autophagy is critical for plant defense against necrotrophic pathogens, which causes serious yield loss on crops. However, the post-translational regulatory mechanisms of autophagy pathway in plant resistance against necrotrophs remain poorly understood. In this study, we report that phosphorylation modification on ATG18a, a key regulator of autophagosome formation in Arabidopsis thaliana, constitutes

    更新日期:2020-08-17
  • Ferroptosis: machinery and regulation.
    Autophagy (IF 9.77) Pub Date : 2020-08-26
    Xin Chen,Jingbo Li,Rui Kang,Daniel J Klionsky,Daolin Tang

    Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron-containing enzyme lipoxygenase is the main promoter of ferroptosis by producing lipid hydroperoxides, and its function relies on the activation of ACSL4-dependent lipid biosynthesis. In contrast, the selenium-containing

    更新日期:2020-08-17
  • Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection.
    Autophagy (IF 9.77) Pub Date : 2020-08-11
    Mengling Tang,Zhiqiang Hu,Chenglong Rao,Jiangao Chen,Siqi Yuan,Jiangang Zhang,Chan Mao,Jingmin Yan,Yupei Xia,Meijuan Zhang,Juanjuan Yue,Yang Xiang,Jianping Xie,Xuhu Mao,Qian Li

    ABSTRACT Burkholderia pseudomallei which causes melioidosis with high mortality in humans, has become a global public health concern. Recently, infection-driven lipid droplet accumulation has been related to the progression of host-pathogen interactions, and its contribution to the pathogenesis of infectious disease has been investigated. Here, we demonstrated that B. pseudomallei infection actively

    更新日期:2020-08-11
  • Lighting chaperone-mediated autophagy (CMA) evolution with an ancient LAMP: the existence of a functional CMA activity in fish.
    Autophagy (IF 9.77) Pub Date : 2020-08-10
    Amaury Herpin,Laury Lescat,Julien Bobe,Andreas Jenny,Iban Seiliez

    Chaperone-mediated autophagy (CMA), as one of the main pathways of lysosomal catabolism, plays essential roles for the maintenance of cellular homeostasis. To date, the absence of any identifiable LAMP2A – the necessary and limiting protein required for CMA – in non-tetrapod lineages, led to the paradigm that this cellular process was restricted to mammals and birds. The recent findings of Lescat et

    更新日期:2020-08-10
  • Scission, a critical step in autophagosome formation.
    Autophagy (IF 9.77) Pub Date : 2020-06-16
    Yuchen Lei,Daniel J Klionsky

    ABSTRACT A key feature of macroautophagy (hereafter autophagy) is the formation of the phagophore, a double-membrane compartment sequestering cargos and finally maturing into a vesicle termed an autophagosome; however, where these membranes originate from is not clear. In a previous study, researchers from the Rubinsztein lab proposed a model in which the autophagosome can evolve from the RAB11A-positive

    更新日期:2020-08-08
  • LC3-associated phagocytosis in myeloid cells, a fireman that restrains inflammation and liver fibrosis, via immunoreceptor inhibitory signaling.
    Autophagy (IF 9.77) Pub Date : 2020-05-31
    JingHong Wan,Emmanuel Weiss,Sanae Ben Mkaddem,Morgane Mabire,Pierre-Marie Choinier,Tristan Thibault-Sogorb,Pushpa Hegde,Marcelle Bens,Linda Broer,Hélène Gilgenkrantz,Richard Moreau,Loredana Saveanu,Patrice Codogno,Renato C Monteiro,Sophie Lotersztajn

    Control of systemic and hepatic inflammation, in particular originating from monocytes/macrophages, is crucial to prevent liver fibrosis and its progression to end-stage cirrhosis. LC3-associated phagocytosis (LAP) is a non-canonical form of autophagy that shifts the monocyte/macrophage phenotype to an anti-inflammatory phenotype. In a recent study, we uncovered LAP as a protective mechanism against

    更新日期:2020-08-08
  • Streptococcus pneumoniae promotes its own survival via choline-binding protein CbpC-mediated degradation of ATG14.
    Autophagy (IF 9.77) Pub Date : 2020-06-17
    Sayaka Shizukuishi,Michinaga Ogawa,Akihide Ryo,Makoto Ohnishi

    Streptococcus pneumoniae is an opportunistic bacterial pathogen that can promote severe infection by overcoming the epithelial and blood-brain barrier. Pneumococcal cell-surface virulence factors, including cell wall-anchored choline-binding proteins (Cbps) play pivotal roles in promoting invasive disease. We reported previously that intracellular pneumococci were detected by hierarchical macroautophagic/autophagic

    更新日期:2020-08-08
  • Involvement of phosphorylation of ULK1 in alternative autophagy.
    Autophagy (IF 9.77) Pub Date : 2020-06-16
    Satoru Torii,Shigeomi Shimizu

    Alternative autophagy is an ATG5 (autophagy related 5)-independent, Golgi membrane-derived form of macroautophagy. ULK1 (unc-51 like kinase 1) is an essential initiator not only for canonical autophagy but also for alternative autophagy. However, the mechanism as to how ULK1 differentially regulates both types of autophagy has remained unclear. Recently, we identified a novel phosphorylation site of

    更新日期:2020-08-08
  • Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.
    Autophagy (IF 9.77) Pub Date : 2020-06-16
    Federico Pietrocola,Francesca Castoldi,Frank Madeo,Guido Kroemer

    Caloric restriction mimetics (CRMs) are nontoxic macroautophagy/autophagy enhancers that act through the stimulation of cytoplasmic protein deacetylation reactions. Thus far, three functional classes of CRMs have been described: inhibitors of acetyltransferases (such as spermidine), inhibitors of acetyl coenzyme (AcCoA) synthesis (such as hydroxycitrate) and activators of deacetylases/sirtuins (such

    更新日期:2020-08-08
  • A RILP-regulated pathway coordinating autophagosome biogenesis with transport.
    Autophagy (IF 9.77) Pub Date : 2020-06-28
    Noopur V Khobrekar,Richard B Vallee

    Mammalian cells, including neurons, use macroautophagy (here ‘autophagy’) to degrade damaged proteins and organelles, and recycle nutrients in response to starvation and other forms of cell stress. The basic cellular machinery responsible for autophagy is highly conserved from yeast to mammals. However, evidence for specific adaptations to more complex organisms and in highly differentiated cells (e

    更新日期:2020-08-08
  • MERIT, a cellular system coordinating lysosomal repair, removal and replacement.
    Autophagy (IF 9.77) Pub Date : 2020-06-21
    Jingyue Jia,Aurore Claude-Taupin,Yuexi Gu,Seong Won Choi,Ryan Peters,Bhawana Bissa,Michal H Mudd,Lee Allers,Sandeep Pallikkuth,Keith A Lidke,Michelle Salemi,Brett Phinney,Muriel Mari,Fulvio Reggiori,Vojo Deretic

    Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully known. Our recent work has uncovered a cellular system termed MERIT for lysosomal membrane repair, removal and replacement. Specifically, lysosomal membrane damage induces, in succession, ESCRT-dependent membrane repair, macroautophagy/autophagy-dominant

    更新日期:2020-08-08
  • The C9orf72-SMCR8-WDR41 complex is a GAP for small GTPases.
    Autophagy (IF 9.77) Pub Date : 2020-06-17
    Dan Tang,Jingwen Sheng,Liangting Xu,Chuangye Yan,Shiqian Qi

    Massive expansions of the hexanucleotide in C9orf72 are the primary genetic origins of familial amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). Current studies have found that this repeat sequence participates in the disease process by producing neurotoxic substances and reducing the level of C9orf72 protein; however, the progress in the functional study of C9orf72 is slow

    更新日期:2020-08-08
  • Regulating RIPK1: another way in which ULK1 contributes to survival.
    Autophagy (IF 9.77) Pub Date : 2020-06-24
    Wenxian Wu,Björn Stork

    ABSTRACT The mammalian ULK1 is the central initiating kinase of bulk and selective macroautophagy/autophagy processes. In the past, both autophagy-relevant and non-autophagy-relevant substrates of this Ser/Thr kinase have been reported. Here, we describe our recent finding that ULK1 also regulates TNF signaling pathways. We find that inhibition of autophagy or specifically ULK1 increases TNF-induced

    更新日期:2020-08-08
  • Selective autophagy inhibition through disruption of the PIK3C3-containing complex I.
    Autophagy (IF 9.77) Pub Date : 2020-07-03
    I Pavlinov,M Salkovski,L N Aldrich

    The PIK3C3/VPS34-containing phosphatidylinositol 3-kinase (PtdIns3K) initiation complex (complex I) is necessary for macroautophagy/autophagy initiation and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-ATG14, while the endosomal trafficking complex (complex II) is necessary for vesicle trafficking and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-UVRAG. This composition difference was exploited

    更新日期:2020-08-08
  • AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system.
    Autophagy (IF 9.77) Pub Date : 2020-07-25
    Jingyue Jia,Bhawana Bissa,Lukas Brecht,Lee Allers,Seong Won Choi,Yuexi Gu,Mark Zbinden,Mark R Burge,Graham Timmins,Kenneth Hallows,Christian Behrends,Vojo Deretic

    Lysosomal damage activates AMPK, a regulator of macroautophagy/autophagy and metabolism, and elicits a strong ubiquitination response. Here we show that the cytosolic lectin LGALS9 detects lysosomal membrane breach by binding to lumenal glycoepitopes, and directs both the ubiquitination response and AMPK activation. Proteomic analyses have revealed increased LGALS9 association with lysosomes, and concomitant

    更新日期:2020-08-08
  • Corrigendum.
    Autophagy (IF 9.77) Pub Date : 2020-05-31

    (2020). Corrigendum. Autophagy: Vol. 16, No. 8, pp. 1553-1553.

    更新日期:2020-08-08
  • Correction.
    Autophagy (IF 9.77) Pub Date : 2020-06-16

    (2020). Correction. Autophagy: Vol. 16, No. 8, pp. 1554-1555.

    更新日期:2020-08-08
  • LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells
    Autophagy (IF 9.77) Pub Date : 2020-08-07
    Suyeon Kim; Hanbyoul Cho; Soon-Oh Hong; Se Jin Oh; Hyo-Jung Lee; Eunho Cho; Seon Rang Woo; Joon Seon Song; Joon-Yong Chung; Sung Wook Son; Sang Min Yoon; Yu-Min Jeon; Seunghyun Jeon; Cassian Yee; Kyung-Mi Lee; Stephen M. Hewitt; Jae-Hoon Kim; Kwon-Ho Song; Tae Woo Kim

    Immune selection drives tumor cells to acquire refractory phenotypes. We previously demonstrated that cytotoxic T lymphocyte (CTL)-mediated immune pressure enriches NANOG+ tumor cells with stem-like and immune-refractory properties that make them resistant to CTLs. Here, we report that the emergence of refractory phenotypes is highly associated with an aberrant macroautophagic/autophagic state of the

    更新日期:2020-08-08
  • A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
    Autophagy (IF 9.77) Pub Date : 2020-08-07
    Tetsushi Kataura,Etsu Tashiro,Shota Nishikawa,Kensuke Shibahara,Yoshihito Muraoka,Masahiro Miura,Shun Sakai,Naohiro Katoh,Misato Totsuka,Masafumi Onodera,Kazuo Shin-Ya,Kengo Miyamoto,Yukiko Sasazawa,Nobutaka Hattori,Shinji Saiki,Masaya Imoto

    ABSTRACT Macroautophagy/autophagy plays a critical role in the pathogenesis of various human diseases including neurodegenerative disorders such as Parkinson disease (PD) and Huntington disease (HD). Chemical autophagy inducers are expected to serve as disease-modifying agents by eliminating cytotoxic/damaged proteins. Although many autophagy inducers have been identified, their precise molecular mechanisms

    更新日期:2020-08-08
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