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Emerging Dimensions of Autophagy in Melanoma Autophagy (IF 13.3) Pub Date : 2024-03-18 Christian Pangilinan, Daniel J Klionsky, Chengyu Liang
Macroautophagy/autophagy has previously been regarded as simply a way for cells to deal with nutrient emergency. But explosive work in the last 15 years has given increasingly new knowledge to our ...
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Streptococcus pneumoniae extracellular vesicles aggravate alveolar epithelial barrier disruption via autophagic degradation of OCLN (occludin) Autophagy (IF 13.3) Pub Date : 2024-03-18 Luqing Cui, Ruicheng Yang, Dong Huo, Liang Li, Xinyi Qu, Jundan Wang, Xinyi Wang, Hulin Liu, Huanchun Chen, Xiangru Wang
Streptococcus pneumoniae (S. pneumoniae) represents a major human bacterial pathogen leading to high morbidity and mortality in children and the elderly. Recent research emphasizes the role of extr...
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CASM mediates LRRK2 recruitment and activation under lysosomal stress Autophagy (IF 13.3) Pub Date : 2024-03-18 Tomoki Kuwahara, Takeshi Iwatsubo
Conjugation of ATG8 to single membranes (CASM) at endolysosomal compartments has attracted attention as the non-autophagic function of the Atg8-family protein conjugation system, and the V-ATPase-A...
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Quantitative analysis of the spatial distance between autophagy-related membrane structures and the endoplasmic reticulum in Saccharomyces cerevisiae Autophagy (IF 13.3) Pub Date : 2024-03-13 Yang Shi, Kuninori Suzuki
Macroautophagy/autophagy is the process by which cells degrade their cytoplasmic proteins or organelles in vacuoles to maintain cellular homeostasis under severe environmental conditions. In the ye...
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Coronavirus hijacks STX18-ATG14 axis-regulated lipophagy to evade an anti-viral effect Autophagy (IF 13.3) Pub Date : 2024-03-13 Zhen Yuan, Binbin Ding
ATG14 is a core subunit of the class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1) for macroautophagy/autophagy initiation and also binds to the STX17 to promote autophagosome-lysosome ...
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ATG5 nonautophagically regulates inflammation and differentiation in mouse embryonic stem cells Autophagy (IF 13.3) Pub Date : 2024-03-13 Sheng Li, Bo-Wen Zhang, Qian-Qian Lou, Yue Liu, Zi-Juan Wei, Jing Huang, Kun-Hou Yao, Qian-Ru Xu, Juan Fan, Yan Xi, Lu Yang, Su Chen
Embryonic stem cells (ESCs), with abilities of infinite proliferation (self-renewal) and to differentiate into distinct cell types (pluripotency), show attenuated inflammatory response against cyto...
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Identification of the YIPF3-YIPF4 heterodimer as a novel Golgiphagy receptor Autophagy (IF 13.3) Pub Date : 2024-03-08 Yuxiang Huang, Daniel J. Klionsky
Golgiphagy is a selective form of macroautophagy, characterized by the targeted degradation of Golgi compartments through specific receptors. In two recent studies, the YIPF3-YIPF4 heterodimer has ...
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Pink1 balances reticulophagy and mitophagy by regulating distinct E3 ubiquitin ligases Autophagy (IF 13.3) Pub Date : 2024-03-08 Zhangyuan Yin, Daniel J. Klionsky
The selective clearance of unwanted, damaged or dangerous components by macroautophagy/autophagy is critical for maintaining cellular homeostasis in organisms from yeast to humans. In recent years,...
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Autophagy—the crossword puzzle Autophagy (IF 13.3) Pub Date : 2024-03-05 Daniel J. Klionsky
It’s April, so it is time to lighten up (think April Fools’ Day). In this issue of the journal, I have two different sets of puzzles for you. Of course, these are not just for your amusement; there...
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WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate basal autophagy Autophagy (IF 13.3) Pub Date : 2024-03-07 Athanasios Kournoutis, Trond Lamark, Terje Johansen, Yakubu Princely Abudu
Macroautophagy/autophagy is a conserved lysosomal degradation process composed of both selective and nonselective degradation pathways. The latter occurs upon nutrient depletion. Selective autophag...
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An unexpected journey for BNIP3 Autophagy (IF 13.3) Pub Date : 2024-03-06 José M Delgado, Christopher J Shoemaker
Mitophagy is a cellular process that enables the selective degradation of damaged, dysfunctional, or superfluous mitochondria. During mitophagy, specific proteins recognize and tag mitochondria for...
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CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival Autophagy (IF 13.3) Pub Date : 2024-03-06 Prakash P. Praharaj, Srimanta Patra, Amruta Singh, Debasna P. Panigrahi, Hwa Y. Lee, Mohammad F. Kabir, Muhammad K. Hossain, Samir K. Patra, Birija S. Patro, Shankargouda Patil, Daniel J. Klionsky, Han J. Chae, Sujit K. Bhutia
Mitophagy involves the selective elimination of defective mitochondria during chemotherapeutic stress to maintain mitochondrial homeostasis and sustain cancer growth. Here, we showed that CLU (clus...
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Autophagy—the crossword puzzle answers Autophagy (IF 13.3) Pub Date : 2024-03-05 Daniel J. Klionsky
This is the answers page so you should not be looking at this page unless you have exhausted the possibility of filling in additional words. Are you certain you are done? Maybe you want to put the ...
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International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis Autophagy (IF 13.3) Pub Date : 2024-03-05 Xin Chen, Andrey S. Tsvetkov, Han-Ming Shen, Ciro Isidoro, Nicholas T. Ktistakis, Andreas Linkermann, Werner J.H. Koopman, Hans-Uwe Simon, Lorenzo Galluzzi, Shouqing Luo, Daqian Xu, Wei Gu, Olivier Peulen, Qian Cai, David C. Rubinsztein, Jen-Tsan Chi, Donna D. Zhang, Changfeng Li, Shinya Toyokuni, Jinbao Liu, Jong-Lyel Roh, Enyong Dai, Gabor Juhasz, Wei Liu, Jianhua Zhang, Minghua Yang, Jiao Liu, Ling-Qiang
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is...
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Autophagy sustains mitochondrial respiration and determines resistance to BRAFV600E inhibition in thyroid carcinoma cells Autophagy (IF 13.3) Pub Date : 2024-03-04 Sergio Díaz-Gago, Javier Vicente-Gutiérrez, Jose Manuel Ruiz-Rodríguez, Josep Calafell, Alicia Álvarez-Álvarez, Marina Lasa, Antonio Chiloeches, Pablo Baquero
BRAFV600E is the most prevalent mutation in thyroid cancer and correlates with poor prognosis and therapy resistance. Although selective inhibitors of BRAFV600E have been developed, more advanced t...
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Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner Autophagy (IF 13.3) Pub Date : 2024-03-03 Yaran Wu, Yang Chen, Xiaojing Yan, Xufang Dai, Yaling Liao, Jing Yuan, Liting Wang, Dong Liu, Dun Niu, Liangbo Sun, Lingxi Chen, Yang Zhang, Li Xiang, An Chen, Shuhui Li, Wei Xiang, Zhenhong Ni, Ming Chen, Fengtian He, Mingzhen Yang, Jiqin Lian
Macroautophagy/autophagy-mediated anoikis resistance is crucial for tumor metastasis. As a key autophagy-related protein, ATG4B has been demonstrated to be a prospective anti-tumor target. However,...
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FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy Autophagy (IF 13.3) Pub Date : 2024-02-29 Prajakta Kulkarni, Giang Thanh Nguyen-Dien, Keri-Lyn Kozul, Julia K. Pagan
Mitophagy is a critical mitochondrial quality control process that selectively removes dysfunctional or excess mitochondria through the autophagy-lysosome system. The process is tightly controlled ...
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Neuronal waste management: new roles for autophagy genes in the extrusion of protein aggregates and in longevity Autophagy (IF 13.3) Pub Date : 2024-02-27 Ling-Hsuan Sun, Caitlin Lange, Malene Hansen, Caroline Kumsta
A decline in macroautophagic/autophagic activity with age contributes to the accumulation of damaged molecules and is associated with the impairment of neuronal functions and the onset of age-relat...
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General autophagy-dependent and -independent lipophagic processes collaborate to regulate the overall level of lipophagy in yeast Autophagy (IF 13.3) Pub Date : 2024-02-29 Na Kang, Jinling Tan, Sisi Yan, Leiying Lin, Qiang Gao
Lipophagy in the yeast Saccharomyces cerevisiae is a microautophagic process in which lipid droplets (LDs) are directly engulfed into the vacuole, despite the fact that multiple core ATG (autophagy...
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PtdIns4p is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion Autophagy (IF 13.3) Pub Date : 2024-02-27 Hajnalka Laczkó-Dobos, Arindam Bhattacharjee, Asha Kiran Maddali, András Kincses, Hussein Abuammar, Krisztina Sebők-Nagy, Tibor Páli, András Dér, Tamás Hegedűs, Gábor Csordás, Gábor Juhász
The autophagosomal SNARE STX17 (syntaxin 17) promotes lysosomal fusion and degradation, but its autophagosomal recruitment is incompletely understood. Notably, PtdIns4P is generated on autophagosom...
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The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy Autophagy (IF 13.3) Pub Date : 2024-02-27 Sarah J. Backe, Jennifer A. Heritz, Mehdi Mollapour
Proteostasis, the maintenance of proper protein folding, stability, and degradation within cells, is fundamental for cellular function. Two key players in this intricate cellular process are macroa...
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Aging STINGs: mitophagy at the crossroads of neuroinflammation Autophagy (IF 13.3) Pub Date : 2024-02-27 Juan Ignacio Jiménez-Loygorri, Patricia Boya
Loss of proteostasis and dysregulated mitochondrial function are part of the traditional hallmarks of aging, and in their last revision impaired macroautophagy and chronic inflammation are also inc...
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Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex Autophagy (IF 13.3) Pub Date : 2024-02-26 Ji Hyeon Cho, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Su Jong Han, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Han
Damaged mitochondria accumulation in diabetes is one of the main features that contribute to increased incidence of cognitive impairment by inducing apoptosis. Butyrate is a major metabolite produc...
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TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux Autophagy (IF 13.3) Pub Date : 2024-02-23 Dongdong Zhao, Lihua Qiang, Zehui Lei, Pupu Ge, Zhe Lu, Yiru Wang, Xinwen Zhang, Yuyun Qiang, Bingxi Li, Yu Pang, Lingqiang Zhang, Cui Hua Liu, Jing Wang
Infectious diseases, such as Mycobacterium tuberculosis (Mtb)-caused tuberculosis (TB), remain a global threat exacerbated by increasing drug resistance. Host-directed therapy (HDT) is a promising ...
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Selective degradation of ribosomes during oncogene-induced senescence: molecular insights and biological perspectives Autophagy (IF 13.3) Pub Date : 2024-02-21 Aida Rodríguez López, Lisa B. Frankel
Ribosomes are conserved macromolecular machines that are responsible for protein synthesis in all cells. While our knowledge of ribosome biogenesis and function has increased significantly in recen...
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ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4+ Th1 responses Autophagy (IF 13.3) Pub Date : 2024-02-18 Yuanli Gao, Suilin Chen, Shiming Jiao, Yongling Fan, Xiuxiu Li, Nie Tan, Jiaqin Fang, Luming Xu, Yi Huang, Jing Zhao, Shuai Guo, Taiping Liu, Wenyue Xu
Parasite-specific CD4+ Th1 cell responses are the predominant immune effector for controlling malaria infection; however, the underlying regulatory mechanisms remain largely unknown. This study dem...
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Yapping at the autophagy door? The answer is flowing in the kidney proximal tubule Autophagy (IF 13.3) Pub Date : 2024-02-16 Aurore Claude-Taupin, Fabiola Terzi, Patrice Codogno, Nicolas Dupont
Shear stress induced by urinary flow stimulates macroautophagy (hereafter referred to as autophagy) in kidney proximal tubule epithelial cells. Autophagy and selective degradation of lipid droplets...
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The role of SARS-CoV-2 ORF7a in autophagy flux disruption: implications for viral infection and pathogenesis Autophagy (IF 13.3) Pub Date : 2024-02-15 Shun Li, Hao Zhang, Weichen Li, Jingbo Zhai, Xiaobo Li, Chunfu Zheng
Although alterations in the autophagy-lysosome pathway have been observed in the SARS-CoV-2 infection and invasion process since the outbreak of the coronavirus disease in 2019, the in-depth mechan...
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Did mitophagy follow the origin of mitochondria? Autophagy (IF 13.3) Pub Date : 2024-02-15 Mauro Degli Esposti
Mitophagy is the process of selective autophagy that removes superfluous and dysfunctional mitochondria. Mitophagy was first characterized in mammalian cells and is now recognized to follow several...
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Synthetic autophagy receptor Autophagy (IF 13.3) Pub Date : 2024-02-14 Ziwen Jiang, Yu-Hsuan Kuo, Michelle R. Arkin
Macroautophagy/autophagy receptors target their substrates to phagophores for subsequent sequestration within autophagosomes. During phagophore membrane expansion in mammalian cells, autophagy rece...
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Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis Autophagy (IF 13.3) Pub Date : 2024-02-13 Yiwei Sun, Xi Wang
The lysosomal degradation of the endoplasmic reticulum (ER), known as “reticulophagy”, is important for protein quality control and organelle turnover. Here we present a noncanonical reticulophagy ...
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Defective autophagy and autophagy activators in Myasthenia Gravis: a rare entity and unusual scenario Autophagy (IF 13.3) Pub Date : 2024-02-12 Ghassan M. Sulaiman, Hayder M. Al-Kuraishy, Majid S. Jabir, Hamdoon A. Mohammed, Ali I. Al-Gareeb, Salim Albukhaty, Daniel J. Klionsky, Mosleh M. Abomughaid
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) that results from autoantibodies against nicotinic acetylcholine receptors (nAchRs) at NMJs. These autoantibodies...
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RABC1, an Arabidopsis RAB18 regulates binding and subsequent detachment of autophagosomes from the ER in autophagy Autophagy (IF 13.3) Pub Date : 2024-02-07 Yang Shao, Jiaqi Sun, Hugo Zheng
Macroautophagy/autophagy is a strategy cells use to cope with detrimental conditions, e.g. nutrient deficiency. Phagophores, the precursors to autophagosomes, are initiated and expanded on the endo...
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Enhancement of LC3-associated efferocytosis for the alleviation of intestinal inflammation Autophagy (IF 13.3) Pub Date : 2024-02-04 Ming-Yue Wu, Er-Jin Wang, Richard D. Ye, Jia-Hong Lu
LC3-associated phagocytosis (LAP) is an instrumental machinery for the clearance of extracellular particles including apoptotic cells for the alleviation of inflammation. While pharmacological appr...
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FREE1 regulates phagophore closure in plants Autophagy (IF 13.3) Pub Date : 2024-02-02 Ying Zhu, Yonglun Zeng, Liwen Jiang
Adenosine monophosphate-activated protein kinase (AMPK), the central energy sensor in more complex eukaryotes, can activate macroautophagy/autophagy upon cellular energy deficiency. However, the re...
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The cocoon into a butterfly: why the HVA22 family proteins turned out to be the reticulophagy receptors in plants? Autophagy (IF 13.3) Pub Date : 2024-01-31 Ning Xu, Yingbo Liang, Jun Liu
Selective degradation of the endoplasmic reticulum (ER) by macroautophagy/autophagy (reticulophagy) is essential for maintaining ER morphology and homeostasis under environmental stresses. Several ...
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Degradative autophagy regulates the homeostasis of miRnas to control cancer development Autophagy (IF 13.3) Pub Date : 2024-01-31 Shan-Ying Wu, Chien-An Chu, Sheng-Hui Lan, Hsiao-Sheng Liu
Macroautophagy/autophagy acts as an anti-tumor mechanism in early cancer stages but promotes growth in established tumors. Similarly, miRNAs function as tumor suppressors or oncogenes, depending on...
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The C9orf72-SMCR8 complex suppresses primary ciliogenesis as a RAB8A GAP Autophagy (IF 13.3) Pub Date : 2024-01-31 Dan Tang, Hui Bao, Shiqian Qi
Approximately half of the familial cases of amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD) are attributed to the abnormal GGGGCC repeat expansion within the first intron of...
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ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells Autophagy (IF 13.3) Pub Date : 2024-01-30 Minsoo Koh, Hyesol Lim, Hao Jin, Minjoo Kim, Yeji Hong, Young Keun Hwang, Yunjung Woo, Eun-Sook Kim, Sun Young Kim, Kyung Mee Kim, Hyun Kyung Lim, Joohee Jung, Sujin Kang, Boyoun Park, Han-Byoel Lee, Wonshik Han, Myung-Shik Lee, Aree Moon
Triple-negative breast cancer (TNBC) is associated with a poor prognosis and metastatic growth. TNBC cells frequently undergo macroautophagy/autophagy, contributing to tumor progression and chemoth...
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Ups and downs of lysosomal pH: conflicting roles of LAMP proteins? Autophagy (IF 13.3) Pub Date : 2024-01-25 Jonathan Handy, Gustavo C. Macintosh, Andreas Jenny
The acidic pH of lysosomes is critical for catabolism in eukaryotic cells and is altered in neurodegenerative disease including Alzheimer and Parkinson. Recent reports using Drosophila and mammalia...
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Targeted degradation of SNCA/α-synuclein aggregates in neurodegeneration using the AUTOTAC chemical platform Autophagy (IF 13.3) Pub Date : 2024-01-25 Jihoon Lee, Dabin Yoon, Ki Woon Sung, Eun-Jin Bae, Da-Ha Park, Young Ho Suh, Yong Tae Kwon
Parkinson disease (PD) characterized by dopaminergic neuronal loss is caused by aggregation of misfolded SNCA/α-synuclein. We recently developed autophagy-targeting chimera (AUTOTAC), a targeted pr...
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A liaison between chaperone-mediated autophagy and exocytotic lysosomes controls the dendritic metastable proteome Autophagy (IF 13.3) Pub Date : 2024-01-25 Katarzyna M. Grochowska, Michael R. Kreutz
The neuronal metastable proteome includes several aggregation-prone proteins related to neurodegeneration. The complex morphology of neurons with very thin processes and enhanced protein turnover t...
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Phase transition and lysosomal degradation of expanded CAG repeat RNA suppress global protein synthesis Autophagy (IF 13.3) Pub Date : 2024-01-25 Junmei Lu, Yuyin Pan, Xinran Feng, Boxun Lu
Phase transitions (PT) of biomolecules are heavily involved in neurodegenerative disorders. Almost all previous studies were focusing on the PT of misfolded proteins whereas RNA molecules containin...
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The biological function of cytoplasm-translocated ENDOG (endonuclease G) Autophagy (IF 13.3) Pub Date : 2024-01-25 Wenjun Wang, Jianshuang Li, Qinghua Zhou
ENDOG, a mitochondrial intermembrane space located endonuclease, participates in DNA fragmentation and apoptosis by translocating to the nucleus. ENDOG can also relocate to the mitochondrial matrix...
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CENPN suppresses autophagy and increases paclitaxel resistance in nasopharyngeal carcinoma cells by inhibiting the CREB-VAMP8 signaling axis Autophagy (IF 13.3) Pub Date : 2024-01-25 Bin-Ru Wang, Ji-Bo Han, Yang Jiang, Shan Xu, Rui Yang, Yong-Gang Kong, Ze-Zhang Tao, Qing-Quan Hua, You Zou, Shi-Ming Chen
Chemotherapeutic resistance is one of the most common reasons for poor prognosis of patients with nasopharyngeal carcinoma (NPC). We found that CENPN can promote the growth, proliferation and apopt...
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The role of ATG5 beyond Atg8ylation and autophagy Autophagy (IF 13.3) Pub Date : 2024-01-25 Fulong Wang, Einar S Trosdal, Masroor Ahmad Paddar, Thabata L A Duque, Lee Allers, Michal Mudd, Prithvi R. Akepati, Ruheena javed, Jingyue Jia, Michelle Salemi, Brett Phinney, Vojo Deretic
ATG5 plays a pivotal role in membrane Atg8ylation, influencing downstream processes encompassing canonical autophagy and noncanonical processes. Remarkably, genetic ablation of ATG5 in myeloid cell...
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Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome Autophagy (IF 13.3) Pub Date : 2024-01-25 Kun Gao, Yingji Chen, Ren Mo, Chenji Wang
Mitophagy, the process of removing damaged mitochondria to promote cell survival, plays a crucial role in cellular functionality. However, excessive, or uncontrolled mitophagy can lead to reduced m...
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Invariant BECN1 CXXC motifs bind Zn2+ and regulate structure and function of the BECN1 intrinsically disordered region Autophagy (IF 13.3) Pub Date : 2024-01-25 Shreya Mukhopadhyay, Subeksha Subedi, Jesse B. Hopkins, Angel Ugrinov, Srinivas Chakravarthy, Christopher L. Colbert, Sangita C. Sinha
Autophagy is an essential catabolic cellular homeostasis process conserved in all eukaryotes. BECN1/Beclin 1, a key autophagy protein involved in autophagosome nucleation, contains two invariant Cx...
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Ksp1 is an autophagic receptor protein for the Snx4-assisted autophagy of Ssn2/Med13 Autophagy (IF 13.3) Pub Date : 2024-01-25 Sara E. Hanley, Stephen D. Willis, Steven J. Doyle, Randy Strich, Katrina F. Cooper
Ksp1 is a casein II-like kinase whose activity prevents aberrant macroautophagy/autophagy induction in nutrient-rich conditions in yeast. Here, we describe a kinase-independent role of Ksp1 as a no...
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Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development Autophagy (IF 13.3) Pub Date : 2024-01-25 Xuanhong Jin, Liangkun You, Jincheng Qiao, Weidong Han, Hongming Pan
Colitis-associated colon cancer (CAC) is a distinct form of colorectal cancer that emerges from prolonged colitis in individuals with inflammatory bowel disease (IBD). Chronic inflammation is consi...
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CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling Autophagy (IF 13.3) Pub Date : 2024-01-25 Mingyu Pan, Tongyu Hu, Jiao Lyu, Yue Yin, Jing Sun, Quanyi Wang, Lingxiao Xu, Haiyang Hu, Chen Wang
STING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and...
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Should proteins be interrogated when they conspire? Autophagy (IF 13.3) Pub Date : 2024-01-23 Daniel J. Klionsky
As a follow up to that wildly popular Editor’s Corner, “Look youse guys and gals, dat just ain’t right” published in 2021, I have put together a follow-up guide to some common grammatical mistakes ...
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MCOLN/TRPML channels in the regulation of MTORC1 and autophagy Autophagy (IF 13.3) Pub Date : 2024-01-05 Peng Huang, Rose Yang Dong, Pingping Wang, Mengnan Xu, Xue Sun, Xian-Ping Dong
MCOLN1 and MCOLN3 are two Ca2+ release channels residing in the endolysosomal membrane. They are activated by phosphatidylinositol (PtdIns)-3-phosphate (PtdIns3P) and/or PtdIns(3,5)P2. Their activi...
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Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance Autophagy (IF 13.3) Pub Date : 2024-01-04 Xiaozhen Zhang, Mengyi Lao, Hanshen Yang, Kang Sun, Yunfei Dong, Lihong He, Xinchi Jiang, Honghui Wu, Yangwei Jiang, Muchun Li, Honggang Ying, Xinyuan Liu, Jian Xu, Yan Chen, Hanjia Zhang, Ruhong Zhou, Jianqing Gao, Xueli Bai, Tingbo Liang
Accumulating evidence suggests that cancer-associated fibroblast (CAF) macroautophagy/autophagy is crucial in tumor development and may be a therapeutic target for pancreatic ductal adenocarcinoma ...
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4R MAPT/tau drives endolysosomal and autophagy dysfunction in frontotemporal dementia Autophagy (IF 13.3) Pub Date : 2024-01-04 Christy Hung, Rickie Patani
Dysfunction of the neuronal endolysosome and macroautophagy/autophagy pathway is emerging as an important pathogenic mechanism in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (AL...
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DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas Autophagy (IF 13.3) Pub Date : 2024-01-03 Gamze Bildik, Joshua P. Gray, Weiqun Mao, Hailing Yang, Rumeysa Ozyurt, Vivian R. Orellana, Olivier De Wever, Mark S. Carey, Robert C. Bast, Zhen Lu
Pancreatic ductal adenocarcinoma (PDAC) and low-grade ovarian cancer (LGSOC) are characterized by the prevalence of KRAS oncogene mutations. DIRAS3 is the first endogenous non-RAS protein that hete...
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UBE3C tunes autophagy via ATG4B ubiquitination Autophagy (IF 13.3) Pub Date : 2024-01-03 Chaonan Sun, Yuxin Chen, Qianqian Gu, Yuanyuan Fu, Yao Wang, Cui Liu, Huazhong Xie, Yong Liao, Zhihua Zheng, Peiqing Liu, Min Li
ATG4B is a core protein and essential for cleaving precursor MAP1LC3/LC3 or deconjugating lipidated LC3-II to drive the formation of autophagosomes. The protein stability and activity of ATG4B regu...
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An autophagy-independent role of ULK1/ULK2 in mechanotransduction and breast cancer cell migration Autophagy (IF 13.3) Pub Date : 2024-01-01 Peigang Liang, Bo Wang
The progression of breast cancer is often accompanied by changes in extracellular matrix stiffness and cell adhesion ability, which are closely related to cellular mechanotransduction. However, the...
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REEPing the harvest of reticulophagy and nucleophagy Autophagy (IF 13.3) Pub Date : 2024-01-01 Chen-Xi Zou, Li-Lin Du
Under stress conditions, the endoplasmic reticulum and nucleus undergo turnover through selective macroautophagy/autophagy processes termed reticulophagy and nucleophagy, respectively. Our recent s...
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Control of nuclear envelope dynamics during acute ER stress by LINC complexes disassembly and selective, asymmetric autophagy of the outer nuclear membrane Autophagy (IF 13.3) Pub Date : 2023-12-28 Marika K. Kucińska, Maurizio Molinari
The endoplasmic reticulum (ER) extends to the outer (ONM) and the inner (INM) nuclear membrane forming the nuclear envelope (NE) that delimits the nucleoplasm containing the cell genome. Unfolded p...