Structural insights into human organic cation transporter 1 transport and inhibition
Cell Discov.
(IF 33.5 )
Pub Date : 2024-03-15
Shuhao Zhang, Angqi Zhu, Fang Kong, Jianan Chen, Baoliang Lan, Guodong He, Kaixuan Gao, Lili Cheng, Xiaoou Sun, Chuangye Yan, Ligong Chen, Xiangyu Liu
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes
Cell Discov.
(IF 33.5 )
Pub Date : 2024-03-12
Chunchun Yuan, Xiang-Tian Yu, Jing Wang, Bing Shu, Xiao-Yun Wang, Chen Huang, Xia Lv, Qian-Qian Peng, Wen-Hao Qi, Jing Zhang, Yan Zheng, Si-Jia Wang, Qian-Qian Liang, Qi Shi, Ting Li, He Huang, Zhen-Dong Mei, Hai-Tao Zhang, Hong-Bin Xu, Jiarui Cui, Hongyu Wang, Hong Zhang, Bin-Hao Shi, Pan Sun, Hui Zhang, Zhao-Long Ma, Yuan Feng, Luonan Chen, Tao Zeng, De-Zhi Tang, Yong-Jun Wang
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies
Cell Discov.
(IF 33.5 )
Pub Date : 2024-03-07
Wanbing Zhao, Kaien Liu, Yun Fan, Qinyue Zhao, Youqi Tao, Mengwei Zhang, Linhua Gan, Wenbo Yu, Bo Sun, Dan Li, Cong Liu, Jian Wang
Mapping crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq
Cell Discov.
(IF 33.5 )
Pub Date : 2024-03-05
Yan Wang, Yijun Chen, Junpeng Gao, Haoling Xie, Yuqing Guo, Jingwei Yang, Jun’e Liu, Zonggui Chen, Qingqing Li, Mengyao Li, Jie Ren, Lu Wen, Fuchou Tang
COASY variant as a new genetic cause of riboflavin-responsive lipid storage myopathy
Cell Discov.
(IF 33.5 )
Pub Date : 2024-02-27
Yilei Zheng, Tongling Liufu, Bing Wen, Chao Zhou, Lingchun Liu, Yusen Qiu, Wenquan Zou, Wei Zhang, Yu Li, Jianfeng Pei, Yiheng Zeng, Wanjin Chen, Chunhua Zhang, Yun Yuan, Guochun Wang, Chuanzhu Yan, Xin Lu, Jianwen Deng, Zhaoxia Wang, Daojun Hong
Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum
Cell Discov.
(IF 33.5 )
Pub Date : 2024-02-26
Fuqiang Yang, Ziqi Zhao, Dan Zhang, Yu Xiong, Xinran Dong, Yuchen Wang, Min Yang, Taotao Pan, Chuanyu Liu, Kaiyi Liu, Yifeng Lin, Yongjie Liu, Qiang Tu, Yashan Dang, Mingyang Xia, Da Mi, Wenhao Zhou, Zhiheng Xu
Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes
Cell Discov.
(IF 33.5 )
Pub Date : 2024-02-20
Tanglong Yuan, Leilei Wu, Shiyan Li, Jitan Zheng, Nana Li, Xiao Xiao, Haihang Zhang, Tianyi Fei, Long Xie, Zhenrui Zuo, Di Li, Pinzheng Huang, Hu Feng, Yaqi Cao, Nana Yan, Xinming Wei, Lei Shi, Yongsen Sun, Wu Wei, Yidi Sun, Erwei Zuo
Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy
Cell Discov.
(IF 33.5 )
Pub Date : 2024-02-13
Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-Min Zhao
Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins
Cell Discov.
(IF 33.5 )
Pub Date : 2024-02-13
Zhaotong Cong, Fenghui Zhao, Yang Li, Gan Luo, Yiting Mai, Xianyue Chen, Yanyan Chen, Shi Lin, Xiaoqing Cai, Qingtong Zhou, Dehua Yang, Ming-Wei Wang
Immune checkpoints HLA-E:CD94-NKG2A and HLA-C:KIR2DL1 complementarily shield circulating tumor cells from NK-mediated immune surveillance
Cell Discov.
(IF 33.5 )
Pub Date : 2024-02-09
Xiaowei Liu, Fengli Zuo, Jinen Song, Leyi Tang, Xueyan Wang, Xinyu Liu, Hao Zhang, Zhankun Yang, Jing Jing, Xuelei Ma, Hubing Shi
Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination
Cell Discov.
(IF 33.5 )
Pub Date : 2024-02-06
Xiaoyu Zhao, Tianyi Qiu, Xiner Huang, Qiyu Mao, Yajie Wang, Rui Qiao, Jiayan Li, Tiantian Mao, Yuan Wang, Yewei Cun, Caicui Wang, Cuiting Luo, Chaemin Yoon, Xun Wang, Chen Li, Yuchen Cui, Chaoyue Zhao, Minghui Li, Yanjia Chen, Guonan Cai, Wenye Geng, Zixin Hu, Jinglei Cao, Wenhong Zhang, Zhiwei Cao, Hin Chu, Lei Sun, Pengfei Wang
Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis
Cell Discov.
(IF 33.5 )
Pub Date : 2024-01-31
Alexandre G. Casanova, Gael S. Roth, Simone Hausmann, Xiaoyin Lu, Ludivine J. M. Bischoff, Emilie M. Froeliger, Lucid Belmudes, Ekaterina Bourova-Flin, Natasha M. Flores, Ana Morales Benitez, Tourkian Chasan, Marcello Caporicci, Jessica Vayr, Sandrine Blanchet, Francesco Ielasi, Sophie Rousseaux, Pierre Hainaut, Or Gozani, Muriel Le Romancer, Yohann Couté, Andres Palencia, Pawel K. Mazur, Nicolas Reynoird
Designed allosteric protein logic
Cell Discov.
(IF 33.5 )
Pub Date : 2024-01-16
Tjaša Plaper, Estera Merljak, Tina Fink, Tadej Satler, Ajasja Ljubetič, Duško Lainšček, Vid Jazbec, Mojca Benčina, Sintija Stevanoska, Sašo Džeroski, Roman Jerala
Neutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine
Cell Discov.
(IF 33.5 )
Pub Date : 2024-01-09
Hui Zhao, Na-Na Zhang, Suad Hannawi, Ai-Ru Zhu, Xiao-Chuan Xiong, Yi-Jiao Huang, Dan-Dan Yu, Can-Jie Chen, Jun Dai, Alaa Abuquta, Bo Ying, Jin-Cun Zhao, Cheng-Feng Qin
Fusogenicity of SARS-CoV-2 BA.2.86 subvariant and its sensitivity to the prokaryotic recombinant EK1 peptide
Cell Discov.
(IF 33.5 )
Pub Date : 2024-01-09
Lijue Wang, Fanke Jiao, Hanxiao Jiang, Yitao Yang, Ziqi Huang, Qian Wang, Wei Xu, Yun Zhu, Shuai Xia, Shibo Jiang, Lu Lu
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma
Cell Discov.
(IF 33.5 )
Pub Date : 2024-01-09
Wen Lei, Ai Zhao, Hui Liu, Chunmei Yang, Cheng Wei, Shanshan Guo, Zhilu Chen, Qunyi Guo, Linjie Li, Mingzhe Zhao, Gongqiang Wu, Guifang Ouyang, Ming Liu, Jinyi Zhang, Jimin Gao, Wenbin Qian
Structural insights into the activation of the divisome complex FtsWIQLB
Cell Discov.
(IF 33.5 )
Pub Date : 2024-01-03
Lili Yang, Yujiao Chen, Shenghai Chang, Chongrong Shen, Xin Wang, Changbin Zhang, Zhibo Zhang, Bi-Sen Ding, Zhaoming Su, Haohao Dong, Xiaodi Tang
TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons
Cell Discov.
(IF 33.5 )
Pub Date : 2024-01-03
Guolin Yang, Min Jia, Guizhou Li, Yan-Yu Zang, Yang-Yang Chen, Yue-Ying Wang, Shi-Yu Zhan, Shi-Xiao Peng, Guoqiang Wan, Wei Li, Jian-Jun Yang, Yun Stone Shi
Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities
Cell Discov.
(IF 33.5 )
Pub Date : 2023-12-19
Chao Chen, Cai-Jin Lin, Yu-Chen Pei, Ding Ma, Li Liao, Si-Yuan Li, Lei Fan, Gen-Hong Di, Song-Yang Wu, Xi-Yu Liu, Yun-Jin Wang, Qi Hong, Guo-Liang Zhang, Lin-Lin Xu, Bei-Bei Li, Wei Huang, Jin-Xiu Shi, Yi-Zhou Jiang, Xin Hu, Zhi-Ming Shao
Multiple-cohort study of the elderly to determine the immunological characteristics and pathogenic mechanisms of severe community-acquired pneumonia caused by the low-virulence virus SARS-CoV-2 Omicron variant
Cell Discov.
(IF 33.5 )
Pub Date : 2023-12-05
Tianyu Lu, Qiuhong Man, Shuai Xia, Xiaohang Liu, Yan Yan, Xueying Yu, Yan Fu, Wanli Liu, Lu Lu, Shibo Jiang, Lize Xiong
Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
Cell Discov.
(IF 33.5 )
Pub Date : 2023-11-28
Xin Pan, Fang Ye, Peiruo Ning, Zhiyi Zhang, Xinyu Li, Binghao Zhang, Qian Wang, Geng Chen, Wei Gao, Chen Qiu, Zhangsong Wu, Jiancheng Li, Lizhe Zhu, Jiang Xia, Kaizheng Gong, Yang Du
Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B
Cell Discov.
(IF 33.5 )
Pub Date : 2023-11-21
Yuhui Fu, Binbin Ding, Xiaoxia Liu, Shangang Zhao, Fang Chen, Linsen Li, Yi Zhu, Jingxuan Zhao, Zhen Yuan, Yafeng Shen, Chaofeng Yang, Mengle Shao, She Chen, Perry E. Bickel, Qing Zhong
Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer
Cell Discov.
(IF 33.5 )
Pub Date : 2023-11-15
Daniel Morales Borràs, Sara Verbandt, Markus Ausserhofer, Gregor Sturm, Jinyeong Lim, Gil Arasa Verge, Isaure Vanmeerbeek, Raquel S. Laureano, Jannes Govaerts, Jenny Sprooten, Yourae Hong, Rebecca Wall, Gert De Hertogh, Xavier Sagaert, Gabriele Bislenghi, André D’Hoore, Albert Wolthuis, Francesca Finotello, Woong-Yang Park, Stefan Naulaerts, Sabine Tejpar, Abhishek D. Garg
VH-CH1 switch region-inserting multispecific antibody designs and their efficacy against SARS-CoV-2 in vitro and in vivo
Cell Discov.
(IF 33.5 )
Pub Date : 2023-11-11
Lili Wu, Yue Gao, Dandan Yu, Sheng Liu, Runchu Zhao, Dezhi Liu, Ling Xu, Honghui Liu, Xiaoyun Wang, Jianxun Qi, Yan Chai, Liya Wei, Yong-Gang Yao, George F. Gao, Qihui Wang
SGF29 nuclear condensates reinforce cellular aging
Cell Discov.
(IF 33.5 )
Pub Date : 2023-11-07
Kaowen Yan, Qianzhao Ji, Dongxin Zhao, Mingheng Li, Xiaoyan Sun, Zehua Wang, Xiaoqian Liu, Zunpeng Liu, Hongyu Li, Yingjie Ding, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Author Correction: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury
Cell Discov.
(IF 33.5 )
Pub Date : 2023-11-03
Yingting Zhang, Xidai Long, Xin Ruan, Qian Wei, Lin Zhang, Lulu Wo, Dongdong Huang, Longshuai Lin, Difei Wang, Li Xia, Qinghua Zhao, Junling Liu, Qian Zhao, Ming He
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis
Cell Discov.
(IF 33.5 )
Pub Date : 2023-10-17
Zhaoxian Cai, Xiaotian Wu, Zijun Song, Shumin Sun, Yunxing Su, Tianyi Wang, Xihao Cheng, Yingying Yu, Chao Yu, En Chen, Wenteng Chen, Yongping Yu, Andreas Linkermann, Junxia Min, Fudi Wang
Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis
Cell Discov.
(IF 33.5 )
Pub Date : 2023-10-10
Huihui Li, Mingzhi Zhang, Quanyi Zhao, Wanqing Zhao, Yan Zhuang, Jin Wang, Weijian Hang, Zheng Wen, Li Wang, Chen Chen, Dao Wen Wang
Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis
Cell Discov.
(IF 33.5 )
Pub Date : 2023-10-05
Jia Shen, Siyu Zhao, Mei Peng, Yanguo Li, Lichao Zhang, Xiaoping Li, Yunyi Hu, Mingrou Wu, Suoyu Xiang, Xiaoying Wu, Jiahua Liu, Beibei Zhang, Zebin Chen, Datao Lin, Huanyao Liu, Wenyan Tang, Jun Chen, Xi Sun, Qi Liao, Geoff Hide, Zhijun Zhou, Zhao-Rong Lun, Zhongdao Wu
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression
Cell Discov.
(IF 33.5 )
Pub Date : 2023-09-19
Yan Wang, Bing Liu, Qingjie Min, Xin Yang, Shi Yan, Yuanyuan Ma, Shaolei Li, Jiawen Fan, Yaqi Wang, Bin Dong, Huajing Teng, Dongmei Lin, Qimin Zhan, Nan Wu
A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer
Cell Discov.
(IF 33.5 )
Pub Date : 2023-09-15
Shuyu Zhai, Jiewei Lin, Yuchen Ji, Ronghao Zhang, Zehui Zhang, Yizhi Cao, Yang Liu, Xiaomei Tang, Jia Liu, Pengyi Liu, Jiayu Lin, Fanlu Li, Hongzhe Li, Yusheng Shi, Da Fu, Xiaxing Deng, Baiyong Shen
CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety
Cell Discov.
(IF 33.5 )
Pub Date : 2023-09-12
Xiangjia Zhu, Jiaqi Meng, Chaofeng Han, Qingfeng Wu, Yu Du, Jiao Qi, Ling Wei, Hao Li, Wenwen He, Keke Zhang, Yi Lu
Derivation of transgene-free bat induced pluripotent stem cells amenable to chimera formation in mice, pigs, and chicks
Cell Discov.
(IF 33.5 )
Pub Date : 2023-09-05
Yumin Qin, Chongyang Li, Xin Gao, Yuanyuan Wu, Zihang Guo, Fei Gao, Dawei Yu, Sen Wu, Xuguang Du
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression
Cell Discov.
(IF 33.5 )
Pub Date : 2023-08-29
Shao-Qi Zhang, Qiao Deng, Qi Zhu, Zhuang-Li Hu, Li-Hong Long, Peng-Fei Wu, Jin-Gang He, Hong-Sheng Chen, Zhenyu Yue, Jia-Hong Lu, Fang Wang, Jian-Guo Chen
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