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Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection Cell Death Discov. (IF 7.0) Pub Date : 2024-03-18 Tirza Bidany-Mizrahi, Aya Shweiki, Kian Maroun, Lina Abu-Tair, Bella Mali, Rami I. Aqeilan
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Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-03-15 Wenjun Huang, Qingyun Zhu, Zhichao Shi, Yao Tu, Qinyuan Li, Wenwen Zheng, Zigao Yuan, Lulu Li, Xuyu Zu, Yue Hao, Bizhu Chu, Yuyang Jiang
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PLEKHM2 deficiency induces impaired mitochondrial clearance and elevated ROS levels in human iPSC-derived cardiomyocytes Cell Death Discov. (IF 7.0) Pub Date : 2024-03-15 Jianchao Zhang, Ying Peng, Wanrong Fu, Ruifei Wang, Jinhua Cao, Shuang Li, Xiaoxu Tian, Zhonggen Li, Chongpei Hua, Yafei Zhai, Yangyang Liu, Mengduan Liu, Jihong Sun, Xiaowei Li, Xiaoyan Zhao, Jianzeng Dong
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The mechanism underlying correlation of particulate matter-induced ferroptosis with inflammasome activation and iron accumulation in macrophages Cell Death Discov. (IF 7.0) Pub Date : 2024-03-15 Minkyung Park, Sujeong Park, Yumin Choi, Young-Lai Cho, Min Jeong Kim, Young-Jun Park, Su Wol Chung, Heedoo Lee, Seon-Jin Lee
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MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Alessandra Affinito, Cristina Quintavalle, Rosario Vincenzo Chianese, Giuseppina Roscigno, Danilo Fiore, Valeria D’Argenio, Guglielmo Thomas, Alessia Savarese, Francesco Ingenito, Lorenza Cocca, Silvia Nuzzo, Maxim V. Berezovski, Maria Patrizia Stoppelli, Gerolama Condorelli
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Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis Cell Death Discov. (IF 7.0) Pub Date : 2024-03-12 Qing-Wei Zhang, Xiao-Lu Lin, Zi-Hao Dai, Ran Zhao, Yi-Chao Hou, Qian Liang, Yan Zhang, Zhi-Zheng Ge
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Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K/AKT/mTOR pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Hongli Li, Qinghua Liu, Yaqiong Hu, Chonggao Yin, Yunxiang Zhang, Peng Gao
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Role of protein degradation systems in colorectal cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Zihan Cui, Mingqi Cong, Shengjie Yin, Yuqi Li, Yuguang Ye, Xi Liu, Jing Tang
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Purine salvage–associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model–based study Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Yawen Sun, Wenjuan Liu, Mu Su, Tao Zhang, Xia Li, Wenbin Liu, Yuping Cai, Deli Zhao, Ming Yang, Zhengjiang Zhu, Jialin Wang, Jinming Yu
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MCL1 inhibition: a promising approach to augment the efficacy of sorafenib in NSCLC through ferroptosis induction Cell Death Discov. (IF 7.0) Pub Date : 2024-03-14 Chao-Yuan Huang, Li-Ju Chen, Chi-Shuo Chen, Cheng-Yi Wang, Shiao-Ya Hong
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Ferroptosis: a new hunter of hepatocellular carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-03-13 Yulang Jiang, Yongxin Yu, Ziyang Pan, Christian Glandorff, Mingyu Sun
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NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence Cell Death Discov. (IF 7.0) Pub Date : 2024-03-12 Shuman Zhen, Yunlong Jia, Yan Zhao, Jiali Wang, Boyang Zheng, Tianxu Liu, Yuqing Duan, Wei Lv, Jiaqi Wang, Fan Xu, Yueping Liu, Yi Zhang, Lihua Liu
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USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression Cell Death Discov. (IF 7.0) Pub Date : 2024-03-11 Lisa Kowald, Jens Roedig, Rebekka Karlowitz, Kristina Wagner, Sonja Smith, Thomas Juretschke, Petra Beli, Stefan Müller, Sjoerd J. L. van Wijk
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Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients Cell Death Discov. (IF 7.0) Pub Date : 2024-03-13 Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju
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Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells Cell Death Discov. (IF 7.0) Pub Date : 2024-03-12 Yu-Shan Lin, Zhiwei Sun, Li-Sha Shen, Rui-Hong Gong, Jia-Wen Chen, Yanfeng Xu, Haiyang Yu, Sibao Chen, Guo-Qing Chen
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Hypoxia induced exosomal Circ-ZNF609 promotes pre-metastatic niche formation and cancer progression via miR-150-5p/VEGFA and HuR/ZO-1 axes in esophageal squamous cell carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-03-12 Yu Mao, Jiahao Wang, Yimin Wang, Zhanzhao Fu, Lixin Dong, Jia Liu
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Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-03-11 Xinxing Wan, Linghao Wang, Md Asaduzzaman Khan, Lin Peng, Keke Zhang, Xiaoying Sun, Xuan Yi, Zhouqi Wang, Ke Chen
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Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage Cell Death Discov. (IF 7.0) Pub Date : 2024-03-11 Jingtao Liu, Xiaomei Tan, Li Li, Liying Cao, Yan Zhou, He Li, Ting Peng
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mTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA Cell Death Discov. (IF 7.0) Pub Date : 2024-03-11 Zhengming Yang, Wei Yu, Ankai Xu, Bing Liu, Libin Jin, Huimin Tao, Dimin Wang
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Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2 Cell Death Discov. (IF 7.0) Pub Date : 2024-03-09 Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A. Skowron, Marlena Sekeres, Julia Hoppe, Karina S. Krings, Tanya R. Llewellyn, Christoph Peter, Björn Stork, Nan Qin, Sanil Bhatia, Daniel Nettersheim, Gerhard Fritz, Ana J. García-Sáez, Thomas J. J. Müller, Sebastian Wesselborg
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SLC26A9 promotes colorectal tumorigenesis by modulating Wnt/β-catenin signaling Cell Death Discov. (IF 7.0) Pub Date : 2024-03-09 Minglin Zhang, Zhiyuan Ma, Zhiqiang Yi, Hu Wang, Jiaxing Zhu, Guorong Wen, Hai Jin, Jiaxing An, Zilin Deng, Biguang Tuo, Taolang Li, Xuemei Liu
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Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-03-09 Shuman Zhang, Duo Yun, Hao Yang, Markus Eckstein, Gihan Daw Elbait, Yaxing Zhou, Yanxi Lu, Hai Yang, Jinping Zhang, Isabella Dörflein, Nathalie Britzen-Laurent, Susanne Pfeffer, Marc P. Stemmler, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Hang He, Siyuan Zeng, Bin Lan, Benjamin Frey, Chuanpit Hampel, Eva Lentsch, Paradesi Naidu Gollavilli, Christian Büttner, Arif B. Ekici, Andrew Biankin, Regine
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Uric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation Cell Death Discov. (IF 7.0) Pub Date : 2024-03-09 Hong Liang Lin, Sheng Wang, Kota Sato, Yu Qiao Zhang, Bei Ting He, Jing Xu, Toru Nakazawa, Yong Jie Qin, Hong Yang Zhang
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Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-03-08 Sitian Wei, Jun Zhang, Rong Zhao, Rui Shi, Lanfen An, Zhicheng Yu, Qi Zhang, Jiarui Zhang, Yuwei Yao, Haojia Li, Hongbo Wang
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Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner Cell Death Discov. (IF 7.0) Pub Date : 2024-03-08 Yujian Wang, Jingchang Luo, Xiaolu Guan, Yan Zhao, Li Sun
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Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer’s disease reveals sex-dependent dysregulations Cell Death Discov. (IF 7.0) Pub Date : 2024-03-07 Muhammad Ali, Pierre Garcia, Laetitia P. Lunkes, Alessia Sciortino, Melanie Thomas, Tony Heurtaux, Kamil Grzyb, Rashi Halder, Djalil Coowar, Alex Skupin, Luc Buée, David Blum, Manuel Buttini, Enrico Glaab
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Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor Cell Death Discov. (IF 7.0) Pub Date : 2024-03-07 Lornella Seeneevassen, Anissa Zaafour, Elodie Sifré, Coralie Genevois, Tra Ly Nguyen, Yasmine Pobiedonoscew, Alban Giese, Jérôme Guignard, Camille Tiffon, Benoit Rousseau, Anne-Aurélie Raymond, Geneviève Belleannée, Hélène Boeuf, Caroline Gronnier, Océane C. B. Martin, Julie Giraud, Philippe Lehours, Pierre Dubus, Christine Varon
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The effects of metabolism on the immune microenvironment in colorectal cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-03-07 Xingzhao Chen, Zhiyuan Ma, Zhiqiang Yi, Enqin Wu, Zhengye Shang, Biguang Tuo, Taolang Li, Xuemei Liu
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B cell memory: from generation to reactivation: a multipronged defense wall against pathogens Cell Death Discov. (IF 7.0) Pub Date : 2024-03-07 Madiha Zahra Syeda, Tu Hong, Chunming Huang, Wenhua Huang, Qingchun Mu
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LSD1 modulates the bone metastasis of breast cancer cells through hnRNPA2B1-mediated sorting of exosomal miRNAs Cell Death Discov. (IF 7.0) Pub Date : 2024-03-06 Ziyu Liu, Benkai Xin, Nan Zhang, Peipei An, Yueru Shi, Jingtong Yang, Youzhong Wan, Yuquan He, Xin Hu
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Serpine1 mRNA confers mesenchymal characteristics to the cell and promotes CD8+ T cells exclusion from colon adenocarcinomas Cell Death Discov. (IF 7.0) Pub Date : 2024-03-06 Salvador Polo-Generelo, Cristina Rodríguez-Mateo, Belén Torres, José Pintor-Tortolero, José A. Guerrero-Martínez, Julian König, Jesús Vázquez, Elena Bonzón-Kulichenco, Javier Padillo-Ruiz, Fernando de la Portilla, José C. Reyes, José A. Pintor-Toro
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The potential role of hydrogen sulfide in cancer cell apoptosis Cell Death Discov. (IF 7.0) Pub Date : 2024-03-06 Wei Gao, Ya-Fang Liu, Yan-Xia Zhang, Yan Wang, Yu-Qing Jin, Hang Yuan, Xiao-Yi Liang, Xin-Ying Ji, Qi-Ying Jiang, Dong-Dong Wu
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Targeting cell death pathways in intestinal ischemia-reperfusion injury: a comprehensive review Cell Death Discov. (IF 7.0) Pub Date : 2024-03-04 Fei Wang, Huiming Huang, Xuejiao Wei, Peng Tan, Zhuguo Wang, Zhongdong Hu
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Frontier knowledge and future directions of programmed cell death in clear cell renal cell carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-03-05 Cao Fei, Xu Zhen, Zhang Shiqiang, Pang Jun
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Cancer associated fibroblasts-derived SULF1 promotes gastric cancer metastasis and CDDP resistance through the TGFBR3-mediated TGF-β signaling pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-03-04 Xingchao Fang, Damin Chen, Xinyu Yang, Xiaogang Cao, Quan Cheng, Kanghui Liu, Peng Xu, Yanjuan Wang, Jiafeng Xu, Siguo Zhao, Zhengyuan Yan
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Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells Cell Death Discov. (IF 7.0) Pub Date : 2024-03-01 Hiroto Konishi, Yuya Haga, Moe Okumura, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
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CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-03-02 Shi-qiang Cao, Song-tao Xue, Wen-juan Li, Guo-sheng Hu, Zhi-gang Wu, Jian-cong Zheng, Shu-liang Zhang, Xiao Lin, Chun Chen, Wen Liu, Bin Zheng
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Mechanisms and significance of entosis for tumour growth and progression Cell Death Discov. (IF 7.0) Pub Date : 2024-03-01 Ksenia Аndreevna Gaptulbarova, Irina Alexandrovna Tsydenova, Daria Sergeevna Dolgasheva, Ekaterina Andreevna Kravtsova, Marina Konstantinovna Ibragimova, Sergey Vladimirovich Vtorushin, Nikolai Vasilievich Litviakov
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AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury Cell Death Discov. (IF 7.0) Pub Date : 2024-03-01 Chao Hu, Mengjing Li, Yongzhen Chen, Wei Cheng, Haining Wang, Yiming Zhou, Fengmeng Teng, Tao Ling, Jinshun Pan, Haozhe Xu, Yanan Zheng, Guozhong Ji, Ting Zhao, Qiang You
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SOX2 and OCT4 mediate radiation and drug resistance in pancreatic tumor organoids Cell Death Discov. (IF 7.0) Pub Date : 2024-03-01 Sanjit Roy, Tijana Dukic, Zachery Keepers, Binny Bhandary, Narottam Lamichhane, Jason Molitoris, Young H. Ko, Aditi Banerjee, Hem D. Shukla
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BZW2 promotes malignant progression in lung adenocarcinoma through enhancing the ubiquitination and degradation of GSK3β Cell Death Discov. (IF 7.0) Pub Date : 2024-02-29 Kai Jin, Yongmeng Li, Ruyuan Wei, Yanfei Liu, Shuai Wang, Hui Tian
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Diminished NAD+ levels and activation of retrotransposons promote postovulatory aged oocyte (POAO) death Cell Death Discov. (IF 7.0) Pub Date : 2024-02-28 Ajay K. Singh, Aradhana Mohanty, S. Lava Kumar, Anjali Kumari, Rohit Beniwal, Ajith Kumar Etikuppam, Pravin Birajdar, Athar Mohd, H. B. D. Prasada Rao
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IGF-1-mediated FOXC1 overexpression induces stem-like properties through upregulating CBX7 and IGF-1R in esophageal squamous cell carcinoma Cell Death Discov. (IF 7.0) Pub Date : 2024-02-27 Hao Wu, Zhao-Xing Li, Kang Fang, Zi-Ying Zhao, Ming-Chuang Sun, An-Qi Feng, Zhu-Yun Leng, Ze-Hua Zhang, Yuan Chu, Li Zhang, Tao Chen, Mei-Dong Xu
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CREB5 promotes the proliferation and self-renewal ability of glioma stem cells Cell Death Discov. (IF 7.0) Pub Date : 2024-02-28 Hyun-Jin Kim, Hye-Min Jeon, Don Carlo Batara, Seongsoo Lee, Suk Jun Lee, Jinlong Yin, Sang-Ik Park, Minha Park, Jong Bae Seo, Jinik Hwang, Young Joon Oh, Sung-Suk Suh, Sung-Hak Kim
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LncRNA MACC1-AS1 induces gemcitabine resistance in pancreatic cancer cells through suppressing ferroptosis Cell Death Discov. (IF 7.0) Pub Date : 2024-02-27 Jiyun Zhu, Zehao Yu, Xuguang Wang, Jinghui Zhang, Yi Chen, Kaibo Chen, Bin Zhang, Jianhong Sun, Jianshuai Jiang, Siming Zheng
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The regulated cell death at the maternal-fetal interface: beneficial or detrimental? Cell Death Discov. (IF 7.0) Pub Date : 2024-02-26 Huan Chen, Yin Chen, Qingliang Zheng
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Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers Cell Death Discov. (IF 7.0) Pub Date : 2024-02-22 Zhimin Wang, Meiyu Bi, Xiaoshu Zhe, Xiao Wang, Bai Dai, Xiaoyu Han, Bingxu Ren, Hao Liang, Dongjun Liu
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DNA damage signalling histone H2AX is required for tumour growth Cell Death Discov. (IF 7.0) Pub Date : 2024-02-24 Lizbeth Contreras, Lorena García-Gaipo, Berta Casar, Alberto Gandarillas
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ALYREF-JunD-SLC7A5 axis promotes pancreatic ductal adenocarcinoma progression through epitranscriptome-metabolism reprogramming and immune evasion Cell Death Discov. (IF 7.0) Pub Date : 2024-02-24 Qingbo Meng, Yuting Xie, Kang Sun, Lihong He, Hongkun Wu, Qi Zhang, Tingbo Liang
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The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-02-24 Iva Suman, Lidija Šimić, Gordana Čanadi Jurešić, Sunčica Buljević, Damir Klepac, Robert Domitrović
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Ferroptotic alveolar epithelial type II cells drive TH2 and TH17 mixed asthma triggered by birch pollen allergen Bet v 1 Cell Death Discov. (IF 7.0) Pub Date : 2024-02-23 Linyi Ma, Ying He, Huancheng Xie, Jing Wang, Jiaqian Chen, Shijie Song, Le Zhang, Linmei Li, He Lai, Yongping Liu, Huifang Chen, Xueyan Zhang, Xueting Liu, Zehong Zou, Qingling Zhang, Jie Yan, Ailin Tao
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Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-02-22 Rou Gu, Liping Bai, Fang Yan, Se Zhang, Xianwen Zhang, Ruhua Deng, Xiansi Zeng, Bo Sun, Xiaomei Hu, Ye Li, Jie Bai
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Perilipin 5 deletion protects against nonalcoholic fatty liver disease and hepatocellular carcinoma by modulating lipid metabolism and inflammatory responses Cell Death Discov. (IF 7.0) Pub Date : 2024-02-22 Paola Berenice Mass-Sanchez, Marinela Krizanac, Paula Štancl, Marvin Leopold, Kathrin M. Engel, Eva Miriam Buhl, Josef van Helden, Nikolaus Gassler, Jürgen Schiller, Rosa Karlić, Diana Möckel, Twan Lammers, Steffen K. Meurer, Ralf Weiskirchen, Anastasia Asimakopoulos
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Mechanism and role of mitophagy in the development of severe infection Cell Death Discov. (IF 7.0) Pub Date : 2024-02-19 Lixiu Ma, Tianyu Han, Yi-an Zhan
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IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-02-20 Qing-Rui Wu, Hui Yang, Hui-Dan Zhang, Yong-Jiang Cai, Yan-Xiang Zheng, Heng Fang, Zi-Fan Wang, Su-Juan Kuang, Fang Rao, Huan-Lei Huang, Chun-Yu Deng, Chun-Bo Chen
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Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway Cell Death Discov. (IF 7.0) Pub Date : 2024-02-20 Guanbo Wang, Ruiyu Li, Chen Feng, Kefan Li, Shuai Liu, Qiang Fu
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8-Br-cGMP activates HSPB6 and increases the antineoplastic activity of quinidine in prostate cancer Cell Death Discov. (IF 7.0) Pub Date : 2024-02-19 Yuankang Feng, Zhenlin Huang, Fubo Lu, Liang Song, Ruoyang Liu, Yu Zhang, Ningyang Li, Xu Han, Xiang Li, Keqiang Li, Budeng Huang, Guoqing Xie, Abao Guo, Jinjian Yang, Zhankui Jia
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Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice Cell Death Discov. (IF 7.0) Pub Date : 2024-02-19 Rongrong Liu, Wenjing Shang, Yingying Liu, Yi Xie, Jun Luan, Ting Zhang, Ying Ma, Zengxian Wang, Yan Sun, Xicheng Song, Fengchan Han
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FSP1 is a predictive biomarker of osteosarcoma cells’ susceptibility to ferroptotic cell death and a potential therapeutic target Cell Death Discov. (IF 7.0) Pub Date : 2024-02-17 Elzbieta Panczyszyn, Valentina Saverio, Romina Monzani, Mara Gagliardi, Jelena Petrovic, Jasmina Stojkovska, Licio Collavin, Marco Corazzari
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Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice Cell Death Discov. (IF 7.0) Pub Date : 2024-02-15 Hong Xue, Zhenhua Feng, Putao Yuan, Li Qiao, Qiliang Lou, Xiangde Zhao, Qingliang Ma, Shiyu Wang, Yang Shen, Huali Ye, Jiao Cheng, Jiying Wang, Shuanglin Wan, Boya Zhang, Peihua Shi, Xuewu Sun