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Th1/Th2 cytokine profile in patients with acute and chronic calculus cholecystitis Eur. Cytokine Netw. (IF 2.8) Pub Date : 2024-01-03 Liling Chen, Xinyuan Chen
Background Relatively little is known about the relationship between Th1/Th2 cytokines and calculus cholecystitis (CC). The purpose of this study was to investigate the correlation between serum Th1 and Th2 cytokine expression and CC, including both acute and chronic cases. Methods In total, 102 patients with chronic calculous cholecystitis (CCC), 64 patients with acute calculous cholecystitis (ACC)
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Thymic stromal lymphopoietin suppresses markers of neuroinflammation and the JAK2/STAT5 pathway in activated microglia Eur. Cytokine Netw. (IF 2.8) Pub Date : 2023-12-01
Abstract Thymic stromal lymphopoietin (TSLP) is highly expressed in the central nervous system in response to inflammation, but its exact function remains unclear. In this study, we used a model of LPS-stimulated microglia to investigate the direct impact of TSLP on microglial activation and the underlying mechanism. We measured oxidative stress, expression of microglial activation markers, and inflammatory
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Acetylcholine suppresses LPS-induced endothelial cell activation by inhibiting the MAPK and NF-κB pathways Eur. Cytokine Netw. (IF 2.8) Pub Date : 2023-10-28 Ping Li, Kewen Zhou, Jiehao Li, Xiaodan Xu, Ling Wang, Tinghuai Wang
Background and Objective Endothelial cell activation plays a critical role in leukocyte recruitment during inflammation and infection. We previously found that cholinergic stimulation (via vagus nerve stimulation) attenuates vascular endothelial impairment and reduces the inflammatory profile in ovariectomized rats. However, the specific molecular mechanism is unclear. This study was designed to explore
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Antibodies as tools in cytokine discovery and usage for diagnosis and therapy of inflammatory diseases Eur. Cytokine Netw. (IF 2.8) Pub Date : 2023-08-03 Jo Van Damme, Ghislain Opdenakker, Sam Van Damme, Sofie Struyf
Polyclonal antisera from patients have been at the basis of the description of autoimmune diseases and today monoclonal antibodies are widely used in the therapy of cancer and many inflammatory diseases. How antisera and antibodies in combination with traditional in vitro and in vivo biological test systems have been instrumental reagents for the discovery of new cytokines is illustrated here for interleukin-1
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Clinical relevance and therapeutic potential of IL-38 in immune and non-immune-related disorders Eur. Cytokine Netw. (IF 2.8) Pub Date : 2023-04-27 Mohammad Reza Haghshenas, Mina Roshan Zamir, Mahboubeh Sadeghi, Mohammad Javad Fattahi, Kimia Mirshekari, Abbas Ghaderi
Interleukin-38 (IL-38) is the most recent member of the IL-1 family that acts as a natural inflammatory inhibitor by binding to cognate receptors, particularly the IL-36 receptor. In vitro, animal and human studies on autoimmune, metabolic, cardiovascular and allergic diseases, as well sepsis and respiratory viral infections, have shown that IL-38 exerts an anti-inflammatory activity by modulating
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Evaluation of immunomodulatory effects of co-culture or supernatant of dexamethasone or IFN-γ-treated adipose-derived mesenchymal stem cells on spleen mononuclear cells Eur. Cytokine Netw. (IF 2.8) Pub Date : 2023-04-27 Fatemeh Bayati, Maryam Valadi, Armin Ahmadi, Farangis Najafi, Bita Ansaripour, Ehsan Sharif-Paghaleh
Although mesenchymal stem cells (MSCs) have exhibited promising immunomodulatory potential in preclinical studies, clinical studies have revealed variable results. These results often depend on environmental cues. Pre-conditioning MSCs with cytokines is one of the methods used to enhance their immunomodulatory effects. In this study, we harvested adipose-derived MSCs from mice and cultured them with
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Toll-like receptor agonists, poly(I:C) and flagellin, lead to IL-36γ induction with divergent release kinetics and differentially alter autophagy in primary human keratinocytes Eur. Cytokine Netw. (IF 2.8) Pub Date : 2022-10-25 Christopher J. Papayannakos, Daniel Zhu, Bongseok Jung, Ali A. Rana, James A. DeVoti, Allan L. Abramson, Vincent R. Bonagura, Bettie M. Steinberg
IL-36γ, a pro-inflammatory member of the IL-1 cytokine superfamily, can be induced and secreted by normal human foreskin keratinocytes (HFKs) in response to pathogenic stimuli, however, the mechanisms underlying the secretion are unknown. In this study, we demonstrate that stimulation with the TLR3 agonist, poly (I:C), led to a delayed secretion of IL-36γ compared to stimulation with the TLR5 agonist
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Association of Interleukin-33 with Recurrent Pregnancy Loss in Egyptian Women Eur. Cytokine Netw. (IF 2.8) Pub Date : 2022-10-25 Lamyaa Salem, Ebtihal Eltaieb, Mariam Fathy Abdelmaksoud
Background A successful pregnancy requires a distinct and complex immunological state. Cytokines appear to be critical for the establishment of a tolerogenic environment towards the semi-allogenic foetus during the foeto-maternal interphase, and a shift from a Th1- to a Th2-cytokine profile may be crucial. An imbalance of cytokines can be a significant factor in recurrent pregnancy loss (RPL). Interleukin-33
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Th1 cytokine endotype discriminates and predicts severe complications in COVID-19 Eur. Cytokine Netw. (IF 2.8) Pub Date : 2022-10-25 Takehiro Hasegawa, Takashi Hato, Toshitsugu Okayama, Kazuho Ikeo, Yoshiaki Miyamoto, Niina Iwanaga, Kohjin Suzuki, Maho Yoshida, Kazuto Yamashita, Saya Yamashita, Eiya Tamada, Abdullah Khasawneh, Faith Jessica Paran, Rieko Oyama, Toshio Naito, Kenta Noda, Yoko Tabe
Treatment of severe and critical cases of coronavirus disease 2019 (COVID-19) is still a top priority in public health. Previously, we reported distinct Th1 cytokines related to the pathophysiology of severe COVID-19 condition. In the present study, we investigated the association of Th1 and Th2 cytokine/chemokine endotypes with cell-mediated immunity via multiplex immunophenotyping, single-cell RNA-Seq
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IL-27 attenuates airway inflammation and epithelial-mesenchymal transition in allergic asthmatic mice possibly via the RhoA/ROCK signalling pathway Eur. Cytokine Netw. (IF 2.8) Pub Date : 2022-09-17 Chuanjun Huang, Yan Sun, Na Liu, Ziping Zhang, Xiyan Wang, Degan Lu, Ling Zhou, Caiqing Zhang
Background Asthma is an airway disease characterized by airflow limitation and various additional clinical manifestations. Repeated inflammatory stimulation of the airways leads to epithelial-mesenchymal transition (EMT) which aggravates subepithelial fibrosis during the process of airway remodelling and enhances resistance to corticosteroids and bronchodilators in refractory asthma. There is growing
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Evaluation of effective factors on IL-10 signaling in B cells in patients with selective IgA deficiency Eur. Cytokine Netw. (IF 2.8) Pub Date : 2022-09-17 Yasser Bagheri, Mohsen Saeidi, Reza Yazdani, Fateme Babaha, Reza Falak, Gholamreza Azizi, Marjan Taherian, Fereshteh Salami, Yaghoob Yazdani, Somayeh Sadani, Ali Hosseini, Morteza Motallebnezhad, Hassan Abolhassani, Mehdi Shekarabi, Asghar Aghamohammadi
Background Selective IgA deficiency is the most prevalent form of primary immunodeficiencies. The pathogenesis of the disease is still unknown. Several studies have suggested a defect in B cell responses to IL-10; however, the main reason for this defect has not been reported. Elucidating IL-10 signaling defects and their correlation with clinical manifestations could be helpful for better understanding
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Post-COVID-19 arthritis: is it hyperinflammation or autoimmunity? Eur. Cytokine Netw. (IF 2.8) Pub Date : 2022-02-11 Sara Ibrahim Taha, Sara Farid Samaan, Rehab Ali Ibrahim, Eman Mousa El-Sehsah, Mariam Karam Youssef
Background Various musculoskeletal and autoimmune manifestations have been described in patients with coronavirus disease 2019 (COVID-19). Objectives This study aims to investigate the prevalence and etiology of arthritis in post-COVID Egyptian patients. Methods We included 100 post-COVID Egyptian patients who recovered 6 months ago and assessed several inflammatory and autoimmune markers. Results
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Anti-cytokine therapy and small molecule agents for the treatment of inflammatory bowel disease Eur. Cytokine Netw. (IF 2.8) Pub Date : 2022-02-11 Yuancong Jiang, Deqiang Kong, Xiaolong Miao, Xing Yu, Zelai Wu, Han Liu, Weihua Gong
Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, with multifactorial etiologies has led to a global health-associated burden in many countries. Substantial efforts are devoted to understand the pathogenesis, behavioral and environmental triggers, which may be specifically valuable for the treatment of IBD. The specific pathogenesis underlying IBD is as yet incompletely
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Metabolic link between obesity and autoimmune diseases Eur. Cytokine Netw. (IF 2.8) Pub Date : 2022-02-11 Jacek Karczewski, Aleksandra Zielińska, Rafał Staszewski, Piotr Eder, Agnieszka Dobrowolska
The abnormal accumulation of visceral adipose tissue in obesity is associated with metabolic changes that include altered glucose tolerance, insulin resistance, hyperlipidemia, and metabolic syndrome. Obesity also coincides with increased incidence of autoimmune diseases. Accumulating evidence suggest that prolonged metabolic overload related to overnutrition, influenced by genetic and epigenetic factors
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Aberrant DNA methylation of the promoters of JAK2 and SOCS3 in juvenile systemic lupus erythematosus Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-12-31 Mahsa Keshavarz-Fathi, Golshid Sanati, Maryam Sadr, Bahareh Mohebbi, Vahid Ziaee, Nima Rezaei
Abstract Cytokine dysregulation is one of the important hallmarks of systemic lupus erythematosus (SLE) in both pediatric and adult patients. Owing to the substantial role of Janus kinase (JAK) and suppressor of cytokine signaling (SOCS) in cytokine signaling, we compared the methylation status of the promoter of JAK2 and SOCS3 between patients with JSLE and healthy controls. Methods Peripheral blood
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Interleukin-17A serum levels in young patients with atopic dermatitis and food allergy Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-12-31 Shereen A. Baioumy, Dina E. Sallam, Shaimaa A. Abdalgeleel, Shaimaa H. Fouad, Ahmed S. Khedr, Sara I. Taha
Background Atopic dermatitis (AD) is a common skin disorder accompanied by skin barrier disruption. Patients with AD are commonly affected by food allergy. Objectives The present case-control study aimed to assess interleukin-17A (IL-17A) serum levels in children with AD and food allergies and to determine whether increased serum levels of this inflammatory cytokine correlate with disease severity
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Interleukin 17 antagonist netakimab is effective and safe in the new coronavirus infection (COVID-19) Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-10-05 Maslennikov, Roman, Ivashkin, Vladimir, Vasilieva, Ekaterina, Chipurik, Maxim, Semikova, Polina, Semenets, Victoria, Russkova, Tatyana, Levshina, Anna, Grigoriadis, Diana, Magomedov, Shamil, Efremova, Irina, Dzhakhaya, Natiya
Background Cytokine release syndrome is a serious complication of the new coronavirus infection (COVID-19). The aim of the study was to assess effectiveness and safety of the IL-17 antagonist nekatimab for its treatment. Methods The retrospective study included COVID-19 patients with C-reactive protein levels >60 mg/L. Patients received either netakimab (group NET), IL-6 antagonist tocilizumab (group
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GM-CSF-producing lymphocytes in tumor-draining lymph nodes of patients with bladder cancer Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-10-05 Ariafar, Ali, Zareinejad, Mohammadrasul, Soltani, Mohammadreza, Vahidi, Yasmin, Faghih, Zahra
Background Bladder cancer (BC) is the tenth common cancer worldwide. Despite progress in treatment and the use of chemotherapoeutic drugs, the survival rate of BC patients is still low. Manipulation of the immune system was recently introduced as an interesting alternative treatment for this immunogenic cancer with fewer side effects. Accordingly, in the present study, we assessed the frequency of
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NLRP12 reduces proliferation and inflammation of rheumatoid arthritis fibroblast-like synoviocytes by regulating the NF-κB and MAPK pathways Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-08-11 Zhang, Xin, Nan, He, Guo, Jialong, Liu, Jinyu
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by abnormal synovial hyperplasia and the release of inflammatory cytokines. NLRP12 is a member of the family nod-like receptor (NLR) families that are activators of inflammation. However, the role of NLRP12 in fibroblast-like synoviocytes (FLSs) is still unclear. In the present study, we have investigated the role of NLRP12
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Effect of white tea consumption on serum leptin, TNF-α and UCP1 gene expression in ovariectomized rats Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-08-11 Saral, Sinan, Saydam, Faruk, Dokumacioglu, Eda, Atak, Mehtap, Tümkaya, Levent, Uydu, Hüseyin Avni
Background Obesity and dyslipidemia due to estrogen deficiency are among the important health problems in menopausal women. Increasing evidence reports the anti-obesity and anti-hyperlipidemic properties of tea polyphenols. However, the effect of white tea (WT) with high polyphenol content on overweight and lipid profile is uncertain. Here, we aimed to examine the effects of long-term WT consumption
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Serum Th17 and TNF-α distinguish between patients with occult hepatitis B infection, chronic hepatitis B infection and healthy individuals Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-08-11 Sosa-Jurado, Francisca, Sánchez-Reza, Laura, Mendoza-Torres, Miguel Ángel, Meléndez-Mena, Daniel, García y García, Víctor Hugo, Guzmán-Flores, Belinda, Enciso-Moreno, José Antonio, López-Ramos, Juan Ernesto, Balandrán, Juan Carlos, Vallejo-Ruiz, Verónica, Cortes-Hernández, Paulina, Reyes-Leyva, Julio, Santos-López, Gerardo
Chronic hepatitis B (CHB) is classified into five phases based on virus-host interactions: immune tolerance, immune clearance, inactive carrier state, reactive phase and occult hepatitis B infection (OBI). OBI is an uncommon asymptomatic phase of CHB that can be reactivated when the immune system is compromised, occasionally giving rise to severe liver disease. Host immune factors play essential roles
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Upregulated Tie2 expression in plasma: a potential non-invasive biomarker for the diagnosis of breast cancer Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-08-11 Song, Qingzhu, Zhang, Fenglan, Yuan, Tian, Wei, Yulong
Breast cancer is by far the most common malignancy found in women and causes a significant public health problem around the world. Early diagnosis of cancer plays an important role in successful treatment and survival of patients. This study aims to investigate the possibility of plasma Tie2 to be used as a biomarker for diagnosis of breast cancer. In total, 20 healthy volunteers and 33 breast cancer
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Variations in IL-22, IL-27 and IL-35 serum levels in untreated and treated hepatitis C patients Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-03-07 Azam Taghinejad, Shaghik Barani, Naser Gholijani, Farzad Ghandehari, Soolmaz Khansalar, Morvarid Asadipour, Mohammadali Davarpanah, Mohammadreza Fattahi, Kurosh Kalantar
Background Hepatitis C virus (HCV) is the leading cause of chronic liver diseases including hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. We aimed to assess serum levels of interleukin (IL)-22, IL-27 and IL-35 in patients with hepatitis C and healthy controls to investigate their possible relationship with viral genotypes and liver enzyme levels. Method A total of 30 newly diagnosed hepatitis
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Evaluation of treatment response in active tuberculosis using QuantiFERON-TB Gold Plus Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-03-07 Setareh Mamishi, Majid Marjani, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Shima Mahmoudi
Introduction Tuberculosis (TB) is one of the leading infectious causes of death worldwide and despite the progress recently made in TB control at a global level, the decline in its incidence is still slow. It is therefore crucial to evaluate the performance of new tools for monitoring of TB treatment. The aim of this study was to evaluate the response to tuberculosis treatment using the QuantiFERON-TB
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Absence of increased liver-related inflammatory markers in type 1 diabetes with metabolic syndrome: a nested case-control study from Brazil Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-03-07 Bianca Senger Vasconcelos Barros, Carlos Terra, Marilia Brito Gomes
Aims To examine the relationship between metabolic syndrome and serum levels of interleukin (IL)-6 and IL-17, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), inflammatory biomarkers involved in nonalcoholic fatty liver disease (NAFLD) pathophysiology, in patients with type 1 diabetes. Methods This was a cross-sectional, nested case-control study with 232 patients with type 1 diabetes
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BTK targeting suppresses inflammatory genes and ameliorates insulin resistance Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-03-07 Mohammad Althubiti, Riyad Almaimani, Safaa Yehia Eid, Mohammad Elzubaier, Bassem Refaat, Shakir Idris, Turki Atia Alqurashi, Mahmoud Zaki El-Readi
Type 2 diabetes (T2D) causes profound psychological and physical distress to patients and burdens the health-care system. Although several antidiabetic drugs have been approved, none of them are adequately effective in the long-term management of T2D. Therefore, novel treatment options are needed for disease prevention or delaying disease progression. Bruton’s tyrosine kinase (BTK) is a cytoplasmic
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Extensive longitudinal immune profiling reveals sustained innate immune activaton in COVID-19 patients with unfavorable outcome Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-03-07 Benjamin Schrijver, Jorn L. J. C. Assmann, Adriaan J. van Gammeren, Roel C. H. Vermeulen, Lützen Portengen, Peter Heukels, Anton W. Langerak, Willem A. Dik, Vincent H. J. van der Velden, Ton A. A. M. Ermens
COVID-19 differs substantially between individuals, ranging from mild to severe or even fatal. Heterogeneity in the immune response against SARS-COV-2 likely contributes to this. Therefore, we explored the temporal dynamics of key cellular and soluble mediators of innate and adaptive immune activation in relation to COVID-19 severity and progression. Forty-four patients with a PCR-proven diagnosis
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Innate lymphoid cell subsets and their cytokines in autoimmune diseases Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-03-07 Asma Maleki, Jamal Motallebzadeh Khanmiri, Mohammad Khani Eshrat Abadi, Faezeh Soveyzi, Bobak Moazzami, Michael R. Hamblin, Nima Rezaei
Both the innate and adaptive arms of the immune system are involved in the development of autoimmune diseases. The main mechanism of disease is due to adaptive immune cells that are active against self-antigens. These cells can cause major damage to body tissues. Innate lymphoid cells (ILCs) are an important type of innate immune cell, whose role has been highlighted in recent years. ILCs are responsible
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Interleukin-27 gene variant rs153109 is associated with enhanced cytokine serum levels and susceptibility to Behçet’s disease in the Iranian population Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-03-07 Nasser Gholijani, Gholamreza Daryabor, Kurosh Kalantar, Mohammad-Reza Yazdani, Saeedeh Shenavandeh, Maryam Zahed, Zahra Jafarpour, Mohammad-Reza Malekmakan, Zahra Amirghofran
Behcet’s disease (BD) is a systemic vasculitis, characterized by recurrent oral aphthous, genital ulcers, ocular lesions, and other organ involvement. Interleukin (IL)-27 with its pro- and anti-inflammatory effects might be an important effective cytokine in this disease. The aim of this study was to investigate the association of IL-27 serum concentration and a single-nucleotide polymorphism (SNP)
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Cytokine release syndrome: inhibition of pro-inflammatory cytokines as a solution for reducing COVID-19 mortality Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-01-08 Negar Moradian, Mahdi Gouravani, Mohammad Amin Salehi, Arash Heidari, Melika Shafeghat, Michael R. Hamblin, Nima Rezaei
Coronavirus disease (COVID-19) reached pandemic proportions at the beginning of 2020 and continues to be a worldwide concern. End organ damage and acute respiratory distress syndrome are the leading causes of death in severely or critically ill patients. The elevated cytokine levels in severe patients in comparison with mildly affected patients suggest that cytokine release syndrome (CRS) occurs in
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Interleukin-4-induced natural killer cell antitumor activity in metastatic melanoma patients Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-01-08 Ana M. Vuletić, Gordana M. Konjević, Annette K. Larsen, Nada L. Babović, Vladimir B. Jurišić, Ana Krivokuća, Katarina M. Mirjačić Martinović
NK cells are important effectors of innate immunity that mount the first line of defense toward tumor growth. Interleukin-4 (IL-4) has recently been shown to regulate NK cell function, although its role in the regulation of NK cell function in cancer patients has not been clarified. The aim of this study was to investigate the effect of IL-4 on the function and the receptor characteristics of CD16-defined
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High levels of proinflammatory cytokines IL-6, IL-8, TNF-A, IL-23, and IFN-γ in Tunisian patients with type 1 autoimmune hepatitis Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-01-08 Maroua Chaouali, Mouna Ben Azaiez, Aymen Tezeghdenti, Besma Yacoubi-Oueslati, Ezzedine Ghazouani, Radhia Kochkar
Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology and several cytokines have been implicated in its pathogenesis and onset. Our objective was to determine the profile of pro and anti-inflammatory cytokines, including IL-1β, IL-6, IL-8, IL-23, IFN-γ, TNF-α, IL-10 in autoimmune hepatitis and their association with HLA gene polymorphisms. Serum cytokine levels were determined in 50
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Preconceptional immunization with an allergen inhibits offspring thymic Th17 cells maturation without influence on Th1 and Th2 cells Eur. Cytokine Netw. (IF 2.8) Pub Date : 2021-01-08 Marília Garcia de Oliveira, Fábio da Ressureição Sgnotto, Thamires Rodrigues de Sousa, Beatriz Oliveira Fagundes, Alberto José da Silva Duarte, Jefferson Russo Victor
The mechanisms through which maternal immunization can modulate offspring thymic maturation of lymphocytes are not fully understood. Here, we aimed to evaluate whether maternal OVA-immunization can inhibit the maturation of Th17 cells on offspring thymus. C57BL/6 females were immunized with OVA in Alum or Alum alone and mated with normal WT males. Offspring thymus was evaluated at three or 20 days
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Therapeutic targeting of interleukin-6 for the treatment of COVID-19. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-12-03 Yao Wang,Chen Liu,Xiaolong Miao,Deqiang Kong,Yingli Zhao,Weihua Gong,Xianfeng Ding
Coronavirus disease 19 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in China and has spread worldwide with a significant rate of infection. Considering the elevated levels of proinflammatory cytokines in COVID-19, it is suggested that cytokine storms play a critical role in its pathogenesis, including acute respiratory distress
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Natural cannabinoids suppress the cytokine storm in sepsis-like in vitro model. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-10-02 Yishay Szekely,Merav Ingbir,Ohad S Bentur,Ohad Hochner,Reuven Porat
Natural cannabinoids may have beneficial effects on various tissues and functions including a positive influence on the immune system and the inflammatory process. The purpose of this study was to investigate the effects of natural cannabinoids on the production of pro-inflammatory cytokines by lipopolysaccharide (LPS)-stimulated whole human blood cells. Levels of the pro-inflammatory cytokines interleukin-1β
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Quantification of angiogenic factors and their clinicopathological associations in breast cancer. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-10-02 Parisa Karimzadeh,Zahra Faghih,Negin Rahmani,Fatemeh Eghbali,Mahboobeh Razmkhah
Introduction and aim Breast cancer (BC) is one of the top three common cancers in women, responsible for nearly one-third of all new cancer diagnoses. Angiogenesis plays a crucial role in BC progression. In this study, we aimed to measure the serum concentrations of eight angiogenic factors in BC patients and healthy controls and to assess their correlation with clinicopathological variables. Methods
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IL-17A induction of ADAMTS-5 in differentiated THP-1 cells is modulated by the ERK signaling pathway. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-10-02 Esther Mun Huieh Thou,Quok Cheong Choo,Choy Hoong Chew
Atherosclerosis is initiated when lipoproteins are trapped by proteoglycans in the arterial intima. Macrophages play a vital role in this disease, especially in the formation of foam cells and the regulation of proinflammatory responses. They also participate in plaque stabilization through the secretion of matrix metalloproteinases. Studies have reported the role of ADAMTS proteases in osteoarthritis
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Interleukin-6 and severe COVID-19: a systematic review and meta-analysis. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-10-02 Helia Mojtabavi,Amene Saghazadeh,Nima Rezaei
Background Evidence links COVID-19 severity to hyper-inflammation. Treatment with tocilizumab, a monoclonal antibody directed against the interleukin-6 (IL-6) receptor, was shown to lead to clinical improvement in patients with severe COVID-19. We, therefore, performed the present systematic review and meta-analysis to investigate whether the circulating levels of IL-6 is a reliable indicator of disease
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Comparing effects of low glycemic index/high-fat, high-calorie diet and high-fat, high-calorie diet on cytokine levels of patients with cystic fibrosis: A randomized controlled clinical trial. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-06-09 Zahra Gorji,Mohammadreza Modaresi,Saeed Yekanni-Nejad,Nima Rezaei,Maryam Mahmoudi
The importance of the host inflammatory response, as a central pathological feature of cystic fibrosis, is well recognized. Additionally, hyperglycemia can induce an immune response and consecutively may exacerbate symptoms of this disease. Hence, adherence to a low glycemic index diet, through normalizing blood glucose levels, may reduce inflammation in patients with this disease. This study aimed
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Serum levels of nesfatin-1 and irisin in obese children. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-06-09 Eda Dokumacioglu,Hatice Iskender,Arzu Sahin,Emine Yurdakul Erturk,Ozgur Kaynar
Background: Along with the developing technology in the modern age, physical activity had decreased considerably in children and adolescents alike with a concomittant and rapid increase in the prevalence of childhood obsesity. The purpose of the present study is to measure the levels of serum nesfatin-1 and irisin in obese children. Methods: The present study was carried out with a total of 62 children
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When wrinkles appear on the immune system can it be reversed? Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-06-09 Hiba Sibaii,Salwa Refat El-Zayat,Mona Khalil
During aging, physiological and physical frailty occur, which is accompanied by a decline in adaptive and innate immunity, termed ‘immunosenescence’ characterized by marked changes in the composition, function, and competence of the human immune system. Moreover, the capabilities of the immune system to defend the human body against infections, to detect and destruct malignant or autoreactive cells
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Increase of circulating inflammatory molecules in preeclampsia, an update. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-06-09 Gurhan Guney,Mine Islimye Taskin,Aytekin Tokmak
Special hormonal and immunological changes are required for normal pregnancy continuation. To escape from rejection by the maternal immune system, pregnancy needs an optimum environment with the integration and the balance of immune factors. As an immunologically unique site that permits allogenic fetus to be tolerated by mother, the maternal–fetal interface has a vital role. Microorganisms may trigger
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Interleukin-1β and interleukin-6 in Common Variable Immunodeficiency and their association with subtypes of B cells and response to the Pneumovax-23 vaccine. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-03-02 Laleh Sharifi,Asghar Aghamohammadi,Nima Rezaei,Reza Yazdani,Farhad Rezaei,Saied Bokaie,Farzaneh Tofighi Zavareh,Fatemeh Kiaee,Ali N Kamali,Gholamreza Azizi,Abbas Mirshafiey
Introduction: Common Variable Immunodeficiency (CVID) is the most common symptomatic form of primary immunodeficiencies. Current research data show altered B cells, TLRs, and cytokine profile in CVID patients. The aim of this study was to determine levels of IL-1ß and IL-6 in CVID patients in response to TLRs stimulation and the association of these cytokines with subtypes of B cells and response to
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Effect of folate supplementation on immunological and autophagy markers in experimental nonalcoholic fatty liver disease. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-03-02 Sara Youssry,Maher A Kamel
Background and aims: Chronic hepatic inflammation is an important pathogenic mediator of nonalcoholic fatty liver disease (NAFLD) that contributes to disease severity. It is commonly suggested that autophagy dysfunction may be an underlying cause of nonalcoholic fatty liver disease. However, the exact role of autophagy in lipid metabolism remains controversial. There has been a growing interest in
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Serum levels of interleukin-32 and interleukin-6 in granulomatosis with polyangiitis and microscopic polyangiitis: association with clinical and biochemical findings. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-03-02 Joanna Krajewska Wojciechowska,Katarzyna Kościelska-Kasprzak,Wojciech Krajewski,Krzysztof Morawski
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder of unknown etiology with dysregulated cytokines levels. Objectives: The main aim of this study was to assess the clinical correlation between antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, granulomatosis with polyangiitis (GPA) serum levels of the microscopic polyangiitis (MPA)
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IL-8 as a potential biomarker in Guillain-Barre Syndrome. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-03-02 Gautier Breville,Agustina M Lascano,Pascale Roux-Lombard,Patrice H Lalive
This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), non-inflammatory polyneuropathy (PNP), and other non-inflammatory neurological diseases (functional syndrome or migraine). The results show elevated CSF IL-8
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Effect of cytokines on NK cell activity and activating receptor expression in high-risk cutaneous melanoma patients. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-03-02 Katarina Mirjačić Martinović,Milica Milićević,Annette K Larsen,Radan Džodić,Vladimir Jurišić,Gordana Konjević,Ana Vuletić
Objective: Stage II melanoma patients have high risk for regional and distant metastases and may benefit from novel therapeutic strategies. To clarify the role of NK cells in Stage II melanoma, we characterized the cytotoxic activity of NK cells and the expression of various activating and inhibitory receptors in high-risk cutaneous melanoma patients (Stages IIB and IIC) compared to low-risk patients
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Poly-functional T helper cells in human tonsillar mononuclear cells. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-03-02 Sifei Yu,Xi Luo,Binyan Yang,Li Xiao,Xingmei Wu,Huabin Li,Changyou Wu
Tonsils are important lymphoid organs in which B cells and T cells complete their maturation and identify cells that are infected by pathogens. However, the functions of T cells in human tonsils remain unclear, especially the characteristics of polyfunctional CD4+ T helper cells. In this study, we used multi-color flow cytometry to analyze the expression or co-expression of effector cytokines in CD4+
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Association of elevated interleukin-33 serum levels with tumorstages in patients with prostate cancer. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-03-02 Nazanin Chatrabnous,Abdollah Jafarzadeh,Abass Ghaderi,Ali Ariafar,Najmeh Aminizadeh,Farzaneh Ghassabi,Maryam Nemati
Background: Inflammation has a prominent role in cancer development and interleukin (IL)-33 has both inflammatory and anti-inflammatory properties. The aim of this study was to measure IL-33 quantities and genetic alterations in the rs1929992 SNP within IL-33 gene in patients with prostate cancer (PC). Methods: This investigation was conducted on blood specimens from 150 newly diagnosed PC patients
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IL-10 induces TGF-β secretion, TGF-β receptor II upregulation, and IgA secretion in B cells. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-02-06 Yasser Bagheri,Fateme Babaha,Reza Falak,Reza Yazdani,Gholamreza Azizi,Maryam Sadri,Hassan Abolhassani,Mehdi Shekarabi,Asghar Aghamohammadi
Background: Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming growth factor-beta (TGF-p) in the regulation of B cell class switching the production of immunoglobulin A (IgA); however, the underlying mechanisms remain to be fully elucidated. The objective
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lncRNA NEAT1 regulates fibrosis and inflammatory response induced by nonalcoholic fatty liver by regulating miR-506/GLI3. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-02-06 Si-Si Jin,Xian-Fan Lin,Ju-Zeng Zheng,Qiong Wang,Hua-Qin Guan
Background: As one of the most common liver disorders worldwide, nonalcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver and can lead to inflammation and fibrosis. Long noncoding RNA (lncRNA) NEAT1 was reported to promote NAFLD progress. However, its molecular mechanism in NAFLD was not fully clear. Method: In vitro cellular model of NAFLD was
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Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2/HO-1 signaling pathway. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-02-06 Yuan Zhao,Gao-Yin Kong,Wan-Min Pei,Bo Zhou,Qin-Qin Zhang,Bing-Bing Pan
Background: Dexmedetomidine (Dex), frequently used as an effective sedative, was reported to play a critical role in the protection of multiple organs. However, its underlying mechanism of a putative protective effect on ischemia/reperfusion (I/R)-induced liver injury is still unclear. Methods: A hepatocyte injury model was established by treating WRL-68 cells with oxygen and glucose deprivation/reoxygenation
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IL-38 serum levels in patients with Behcet's disease and the relationship with clinical features. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-02-06 Maryam Zarrabi,Nasser Gholijani,Saeedeh Shenavandeh,Elham Aflaki,Zahra Amirghofran
Behcet’s disease (BD) is a chronic multisystem autoimmune disorder. Various cytokines take part in the pathogenesis of this disease. Interleukin (IL)-38, a new member of IL-1 cytokine family, has been reported to have antiinflammatory properties; however, its role in BD has not been investigated yet. In this study, we aimed to examine the probable role of IL-38 in the clinical context of BD. A total
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Zika virus in the eye of the cytokine storm. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2020-02-06 Christopher Maucourant,Gabriel Andrade Nonato Queiroz,Assia Samri,Maria Fernanda Rios Grassi,Hans Yssel,Vincent Vieillard
Zika virus (ZIKV) is an emerging arbovirus that causes a mosquito-borne disease. Although infection with ZIKV generally leads to mild disease, its recent emergence in the Americas has been associated with an increase in the development of the Guillain-Barré syndrome in adults, as well as with neurological complications, in particular congenital microcephaly, in new-borns. Over the five past years,
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Features of monocyte-derived dendritic cells encompassing a rare subpopulation of cells that are capable of natural internalization of extracellular dsDNA. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2019-09-25 Anastasia S Proskurina,Alisa V Spaselnikova,Genrikh S Ritter,Evgenia V Dolgova,Ekaterina A Potter,Margarita V Romanenko,Sergey V Netesov,Yaroslav R Efremov,Oleg S Taranov,Nikolay A Varaksin,Tatiana G Ryabicheva,Aleksandr A Ostanin,Elena R Chernykh,Sergey S Bogachev
The present study demonstrates that monocyte-derived dendritic cells (moDCs) produced in vitro using a GM-CSF and IFN-α differentiation protocol encompass a rare (T}5%) subpopulation of cells showing classical dendritic cell morphology and capable of natural internalization of extracellular self-DNA.We established that DEFB, HMGB1, LL-37 and RAGE antigens, which mediate the process of DNA internalization
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Effects of IL-34 on the secretion of RANKL/OPG by fibroblast-like synoviocytes and peripheral blood mononuclear cells in rheumatoid arthritis. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2019-09-25 Mei Ying Cui,Xin Li,Yi Meng Lei,Li Ping Xia,Jing Lu,Hui Shen
ObjectiveTo detect the effect of interleukin (IL)-34 on the secretion of Receptor activator of nuclear factor kappa-B ligand (RANKL)/Osteoprotegerin (OPG) and Matrix metalloproteinase (MMP)-3 by fibroblast-like synoviocytes (FLS) and peripheral blood mononuclear cells (PBMCs) of rheumatoid arthritis (RA) patients and to investigate whether the effect is mediated by IL-17. MethodRA-FLS and RA-PBMCs
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Role of IL-33 in transplant biology. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2019-09-25 Ying Jin,Deqiang Kong,Chen Liu,Weihua Gong
Since the pro-inflammatory cytokine IL-33 and its receptor (ST2) are closely involved in regulating both innate and adaptive immune responses, it is conceivable that they may play an important role in organ transplantation. IL-33 is broadly expressed by multiple cell types such as fibroblasts, epithelial cells, and endothelial cells. As a strong inducer of type 2 helper T (Th2) cellular immune responses
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Nicotine exerts neuroprotective effects by attenuating local inflammatory cytokine production following crush injury to rat sciatic nerves. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2019-09-25 Dewei Wang,Tianyang Gao,Yingwei Zhao,Ye Mao,Zhigang Sheng,Qing Lan
BackgroundRecent studies have demonstrated that nicotine exhibited anti-inflammatory and neuroprotective properties by interacting with the alpha 7 nicotinic acetylcholine receptor (α7nAChR). However, the role of nicotine in regeneration during peripheral nerve injury has not been elucidated. The aim of this study was to investigate whether nicotine down-regulated production of proinflammatory cytokines
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Ischemic time of graft liver forces Th1-to-Th2 activity toward Th1 activity in patients who underwent living donor liver transplantation. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2019-05-27 Chul Soo Park,Hye Young Moon,Sangbin Han,Jin Young Chon,Min Suk Chae,Sang Hyun Hong,Jong Ho Choi,Hyun Sik Chung
Recipient’s immune responses are an important factor in allograft survival in transplantation. Cytokines are reflected with immune responses. In the present study, we aimed to evaluate potential affecting factors of liver allograft survival and their possible correlation with seroum cytokine levels in living donor liver transplantation (LDLT). One hundred and seventy-one adult patients’ data were collected
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IL-17, IL-10, IL-6, and IFN-γ in Egyptian Behçet's disease: correlation with clinical manifestations. Eur. Cytokine Netw. (IF 2.8) Pub Date : 2019-05-27 Roba M Talaat,Hiba Sibaii,Iman H Bassyouni,Amany El-Wakkad
There are a limited number of studies that report the polarization of the immune system toward the production of T helper 1 (Th1), Th2, or Th17-type cytokines in patients with Behçet’s disease (BD). Here, we aimed to detect the presence of various cytokines in serum samples of Egyptian BD patients and to determine the correlation between their production levels and clinical manifestations. To that