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Cytokine release syndrome: inhibition of pro-inflammatory cytokines as a solution for reducing COVID-19 mortality Eur. Cytokine Netw. (IF 1.912) Pub Date : 2021-01-08 Negar Moradian, Mahdi Gouravani, Mohammad Amin Salehi, Arash Heidari, Melika Shafeghat, Michael R. Hamblin, Nima Rezaei
Coronavirus disease (COVID-19) reached pandemic proportions at the beginning of 2020 and continues to be a worldwide concern. End organ damage and acute respiratory distress syndrome are the leading causes of death in severely or critically ill patients. The elevated cytokine levels in severe patients in comparison with mildly affected patients suggest that cytokine release syndrome (CRS) occurs in
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Interleukin-4-induced natural killer cell antitumor activity in metastatic melanoma patients Eur. Cytokine Netw. (IF 1.912) Pub Date : 2021-01-08 Ana M. Vuletić, Gordana M. Konjević, Annette K. Larsen, Nada L. Babović, Vladimir B. Jurišić, Ana Krivokuća, Katarina M. Mirjačić Martinović
NK cells are important effectors of innate immunity that mount the first line of defense toward tumor growth. Interleukin-4 (IL-4) has recently been shown to regulate NK cell function, although its role in the regulation of NK cell function in cancer patients has not been clarified. The aim of this study was to investigate the effect of IL-4 on the function and the receptor characteristics of CD16-defined
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High levels of proinflammatory cytokines IL-6, IL-8, TNF-A, IL-23, and IFN-γ in Tunisian patients with type 1 autoimmune hepatitis Eur. Cytokine Netw. (IF 1.912) Pub Date : 2021-01-08 Maroua Chaouali, Mouna Ben Azaiez, Aymen Tezeghdenti, Besma Yacoubi-Oueslati, Ezzedine Ghazouani, Radhia Kochkar
Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology and several cytokines have been implicated in its pathogenesis and onset. Our objective was to determine the profile of pro and anti-inflammatory cytokines, including IL-1β, IL-6, IL-8, IL-23, IFN-γ, TNF-α, IL-10 in autoimmune hepatitis and their association with HLA gene polymorphisms. Serum cytokine levels were determined in 50
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Preconceptional immunization with an allergen inhibits offspring thymic Th17 cells maturation without influence on Th1 and Th2 cells Eur. Cytokine Netw. (IF 1.912) Pub Date : 2021-01-08 Marília Garcia de Oliveira, Fábio da Ressureição Sgnotto, Thamires Rodrigues de Sousa, Beatriz Oliveira Fagundes, Alberto José da Silva Duarte, Jefferson Russo Victor
The mechanisms through which maternal immunization can modulate offspring thymic maturation of lymphocytes are not fully understood. Here, we aimed to evaluate whether maternal OVA-immunization can inhibit the maturation of Th17 cells on offspring thymus. C57BL/6 females were immunized with OVA in Alum or Alum alone and mated with normal WT males. Offspring thymus was evaluated at three or 20 days
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Natural cannabinoids suppress the cytokine storm in sepsis-like in vitro model. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-10-02 Yishay Szekely,Merav Ingbir,Ohad S Bentur,Ohad Hochner,Reuven Porat
Natural cannabinoids may have beneficial effects on various tissues and functions including a positive influence on the immune system and the inflammatory process. The purpose of this study was to investigate the effects of natural cannabinoids on the production of pro-inflammatory cytokines by lipopolysaccharide (LPS)-stimulated whole human blood cells. Levels of the pro-inflammatory cytokines interleukin-1β
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Quantification of angiogenic factors and their clinicopathological associations in breast cancer. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-10-02 Parisa Karimzadeh,Zahra Faghih,Negin Rahmani,Fatemeh Eghbali,Mahboobeh Razmkhah
Introduction and aim Breast cancer (BC) is one of the top three common cancers in women, responsible for nearly one-third of all new cancer diagnoses. Angiogenesis plays a crucial role in BC progression. In this study, we aimed to measure the serum concentrations of eight angiogenic factors in BC patients and healthy controls and to assess their correlation with clinicopathological variables. Methods
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IL-17A induction of ADAMTS-5 in differentiated THP-1 cells is modulated by the ERK signaling pathway. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-10-02 Esther Mun Huieh Thou,Quok Cheong Choo,Choy Hoong Chew
Atherosclerosis is initiated when lipoproteins are trapped by proteoglycans in the arterial intima. Macrophages play a vital role in this disease, especially in the formation of foam cells and the regulation of proinflammatory responses. They also participate in plaque stabilization through the secretion of matrix metalloproteinases. Studies have reported the role of ADAMTS proteases in osteoarthritis
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Interleukin-6 and severe COVID-19: a systematic review and meta-analysis. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-10-02 Helia Mojtabavi,Amene Saghazadeh,Nima Rezaei
Background Evidence links COVID-19 severity to hyper-inflammation. Treatment with tocilizumab, a monoclonal antibody directed against the interleukin-6 (IL-6) receptor, was shown to lead to clinical improvement in patients with severe COVID-19. We, therefore, performed the present systematic review and meta-analysis to investigate whether the circulating levels of IL-6 is a reliable indicator of disease
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Comparing effects of low glycemic index/high-fat, high-calorie diet and high-fat, high-calorie diet on cytokine levels of patients with cystic fibrosis: A randomized controlled clinical trial. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-06-09 Zahra Gorji,Mohammadreza Modaresi,Saeed Yekanni-Nejad,Nima Rezaei,Maryam Mahmoudi
The importance of the host inflammatory response, as a central pathological feature of cystic fibrosis, is well recognized. Additionally, hyperglycemia can induce an immune response and consecutively may exacerbate symptoms of this disease. Hence, adherence to a low glycemic index diet, through normalizing blood glucose levels, may reduce inflammation in patients with this disease. This study aimed
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Serum levels of nesfatin-1 and irisin in obese children. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-06-09 Eda Dokumacioglu,Hatice Iskender,Arzu Sahin,Emine Yurdakul Erturk,Ozgur Kaynar
Background: Along with the developing technology in the modern age, physical activity had decreased considerably in children and adolescents alike with a concomittant and rapid increase in the prevalence of childhood obsesity. The purpose of the present study is to measure the levels of serum nesfatin-1 and irisin in obese children. Methods: The present study was carried out with a total of 62 children
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When wrinkles appear on the immune system can it be reversed? Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-06-09 Hiba Sibaii,Salwa Refat El-Zayat,Mona Khalil
During aging, physiological and physical frailty occur, which is accompanied by a decline in adaptive and innate immunity, termed ‘immunosenescence’ characterized by marked changes in the composition, function, and competence of the human immune system. Moreover, the capabilities of the immune system to defend the human body against infections, to detect and destruct malignant or autoreactive cells
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Increase of circulating inflammatory molecules in preeclampsia, an update. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-06-09 Gurhan Guney,Mine Islimye Taskin,Aytekin Tokmak
Special hormonal and immunological changes are required for normal pregnancy continuation. To escape from rejection by the maternal immune system, pregnancy needs an optimum environment with the integration and the balance of immune factors. As an immunologically unique site that permits allogenic fetus to be tolerated by mother, the maternal–fetal interface has a vital role. Microorganisms may trigger
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Interleukin-1β and interleukin-6 in Common Variable Immunodeficiency and their association with subtypes of B cells and response to the Pneumovax-23 vaccine. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-03-02 Laleh Sharifi,Asghar Aghamohammadi,Nima Rezaei,Reza Yazdani,Farhad Rezaei,Saied Bokaie,Farzaneh Tofighi Zavareh,Fatemeh Kiaee,Ali N Kamali,Gholamreza Azizi,Abbas Mirshafiey
Introduction: Common Variable Immunodeficiency (CVID) is the most common symptomatic form of primary immunodeficiencies. Current research data show altered B cells, TLRs, and cytokine profile in CVID patients. The aim of this study was to determine levels of IL-1ß and IL-6 in CVID patients in response to TLRs stimulation and the association of these cytokines with subtypes of B cells and response to
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Effect of folate supplementation on immunological and autophagy markers in experimental nonalcoholic fatty liver disease. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-03-02 Sara Youssry,Maher A Kamel
Background and aims: Chronic hepatic inflammation is an important pathogenic mediator of nonalcoholic fatty liver disease (NAFLD) that contributes to disease severity. It is commonly suggested that autophagy dysfunction may be an underlying cause of nonalcoholic fatty liver disease. However, the exact role of autophagy in lipid metabolism remains controversial. There has been a growing interest in
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Serum levels of interleukin-32 and interleukin-6 in granulomatosis with polyangiitis and microscopic polyangiitis: association with clinical and biochemical findings. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-03-02 Joanna Krajewska Wojciechowska,Katarzyna Kościelska-Kasprzak,Wojciech Krajewski,Krzysztof Morawski
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder of unknown etiology with dysregulated cytokines levels. Objectives: The main aim of this study was to assess the clinical correlation between antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, granulomatosis with polyangiitis (GPA) serum levels of the microscopic polyangiitis (MPA)
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IL-8 as a potential biomarker in Guillain-Barre Syndrome. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-03-02 Gautier Breville,Agustina M Lascano,Pascale Roux-Lombard,Patrice H Lalive
This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), non-inflammatory polyneuropathy (PNP), and other non-inflammatory neurological diseases (functional syndrome or migraine). The results show elevated CSF IL-8
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Effect of cytokines on NK cell activity and activating receptor expression in high-risk cutaneous melanoma patients. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-03-02 Katarina Mirjačić Martinović,Milica Milićević,Annette K Larsen,Radan Džodić,Vladimir Jurišić,Gordana Konjević,Ana Vuletić
Objective: Stage II melanoma patients have high risk for regional and distant metastases and may benefit from novel therapeutic strategies. To clarify the role of NK cells in Stage II melanoma, we characterized the cytotoxic activity of NK cells and the expression of various activating and inhibitory receptors in high-risk cutaneous melanoma patients (Stages IIB and IIC) compared to low-risk patients
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Poly-functional T helper cells in human tonsillar mononuclear cells. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-03-02 Sifei Yu,Xi Luo,Binyan Yang,Li Xiao,Xingmei Wu,Huabin Li,Changyou Wu
Tonsils are important lymphoid organs in which B cells and T cells complete their maturation and identify cells that are infected by pathogens. However, the functions of T cells in human tonsils remain unclear, especially the characteristics of polyfunctional CD4+ T helper cells. In this study, we used multi-color flow cytometry to analyze the expression or co-expression of effector cytokines in CD4+
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Association of elevated interleukin-33 serum levels with tumorstages in patients with prostate cancer. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-03-02 Nazanin Chatrabnous,Abdollah Jafarzadeh,Abass Ghaderi,Ali Ariafar,Najmeh Aminizadeh,Farzaneh Ghassabi,Maryam Nemati
Background: Inflammation has a prominent role in cancer development and interleukin (IL)-33 has both inflammatory and anti-inflammatory properties. The aim of this study was to measure IL-33 quantities and genetic alterations in the rs1929992 SNP within IL-33 gene in patients with prostate cancer (PC). Methods: This investigation was conducted on blood specimens from 150 newly diagnosed PC patients
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IL-10 induces TGF-β secretion, TGF-β receptor II upregulation, and IgA secretion in B cells. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-02-06 Yasser Bagheri,Fateme Babaha,Reza Falak,Reza Yazdani,Gholamreza Azizi,Maryam Sadri,Hassan Abolhassani,Mehdi Shekarabi,Asghar Aghamohammadi
Background: Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming growth factor-beta (TGF-p) in the regulation of B cell class switching the production of immunoglobulin A (IgA); however, the underlying mechanisms remain to be fully elucidated. The objective
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lncRNA NEAT1 regulates fibrosis and inflammatory response induced by nonalcoholic fatty liver by regulating miR-506/GLI3. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-02-06 Si-Si Jin,Xian-Fan Lin,Ju-Zeng Zheng,Qiong Wang,Hua-Qin Guan
Background: As one of the most common liver disorders worldwide, nonalcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver and can lead to inflammation and fibrosis. Long noncoding RNA (lncRNA) NEAT1 was reported to promote NAFLD progress. However, its molecular mechanism in NAFLD was not fully clear. Method: In vitro cellular model of NAFLD was
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Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2/HO-1 signaling pathway. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-02-06 Yuan Zhao,Gao-Yin Kong,Wan-Min Pei,Bo Zhou,Qin-Qin Zhang,Bing-Bing Pan
Background: Dexmedetomidine (Dex), frequently used as an effective sedative, was reported to play a critical role in the protection of multiple organs. However, its underlying mechanism of a putative protective effect on ischemia/reperfusion (I/R)-induced liver injury is still unclear. Methods: A hepatocyte injury model was established by treating WRL-68 cells with oxygen and glucose deprivation/reoxygenation
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IL-38 serum levels in patients with Behcet's disease and the relationship with clinical features. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-02-06 Maryam Zarrabi,Nasser Gholijani,Saeedeh Shenavandeh,Elham Aflaki,Zahra Amirghofran
Behcet’s disease (BD) is a chronic multisystem autoimmune disorder. Various cytokines take part in the pathogenesis of this disease. Interleukin (IL)-38, a new member of IL-1 cytokine family, has been reported to have antiinflammatory properties; however, its role in BD has not been investigated yet. In this study, we aimed to examine the probable role of IL-38 in the clinical context of BD. A total
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Zika virus in the eye of the cytokine storm. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2020-02-06 Christopher Maucourant,Gabriel Andrade Nonato Queiroz,Assia Samri,Maria Fernanda Rios Grassi,Hans Yssel,Vincent Vieillard
Zika virus (ZIKV) is an emerging arbovirus that causes a mosquito-borne disease. Although infection with ZIKV generally leads to mild disease, its recent emergence in the Americas has been associated with an increase in the development of the Guillain-Barré syndrome in adults, as well as with neurological complications, in particular congenital microcephaly, in new-borns. Over the five past years,
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Features of monocyte-derived dendritic cells encompassing a rare subpopulation of cells that are capable of natural internalization of extracellular dsDNA. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-09-25 Anastasia S Proskurina,Alisa V Spaselnikova,Genrikh S Ritter,Evgenia V Dolgova,Ekaterina A Potter,Margarita V Romanenko,Sergey V Netesov,Yaroslav R Efremov,Oleg S Taranov,Nikolay A Varaksin,Tatiana G Ryabicheva,Aleksandr A Ostanin,Elena R Chernykh,Sergey S Bogachev
The present study demonstrates that monocyte-derived dendritic cells (moDCs) produced in vitro using a GM-CSF and IFN-α differentiation protocol encompass a rare (T}5%) subpopulation of cells showing classical dendritic cell morphology and capable of natural internalization of extracellular self-DNA.We established that DEFB, HMGB1, LL-37 and RAGE antigens, which mediate the process of DNA internalization
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Effects of IL-34 on the secretion of RANKL/OPG by fibroblast-like synoviocytes and peripheral blood mononuclear cells in rheumatoid arthritis. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-09-25 Mei Ying Cui,Xin Li,Yi Meng Lei,Li Ping Xia,Jing Lu,Hui Shen
ObjectiveTo detect the effect of interleukin (IL)-34 on the secretion of Receptor activator of nuclear factor kappa-B ligand (RANKL)/Osteoprotegerin (OPG) and Matrix metalloproteinase (MMP)-3 by fibroblast-like synoviocytes (FLS) and peripheral blood mononuclear cells (PBMCs) of rheumatoid arthritis (RA) patients and to investigate whether the effect is mediated by IL-17. MethodRA-FLS and RA-PBMCs
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Role of IL-33 in transplant biology. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-09-25 Ying Jin,Deqiang Kong,Chen Liu,Weihua Gong
Since the pro-inflammatory cytokine IL-33 and its receptor (ST2) are closely involved in regulating both innate and adaptive immune responses, it is conceivable that they may play an important role in organ transplantation. IL-33 is broadly expressed by multiple cell types such as fibroblasts, epithelial cells, and endothelial cells. As a strong inducer of type 2 helper T (Th2) cellular immune responses
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Nicotine exerts neuroprotective effects by attenuating local inflammatory cytokine production following crush injury to rat sciatic nerves. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-09-25 Dewei Wang,Tianyang Gao,Yingwei Zhao,Ye Mao,Zhigang Sheng,Qing Lan
BackgroundRecent studies have demonstrated that nicotine exhibited anti-inflammatory and neuroprotective properties by interacting with the alpha 7 nicotinic acetylcholine receptor (α7nAChR). However, the role of nicotine in regeneration during peripheral nerve injury has not been elucidated. The aim of this study was to investigate whether nicotine down-regulated production of proinflammatory cytokines
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Ischemic time of graft liver forces Th1-to-Th2 activity toward Th1 activity in patients who underwent living donor liver transplantation. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-05-27 Chul Soo Park,Hye Young Moon,Sangbin Han,Jin Young Chon,Min Suk Chae,Sang Hyun Hong,Jong Ho Choi,Hyun Sik Chung
Recipient’s immune responses are an important factor in allograft survival in transplantation. Cytokines are reflected with immune responses. In the present study, we aimed to evaluate potential affecting factors of liver allograft survival and their possible correlation with seroum cytokine levels in living donor liver transplantation (LDLT). One hundred and seventy-one adult patients’ data were collected
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IL-17, IL-10, IL-6, and IFN-γ in Egyptian Behçet's disease: correlation with clinical manifestations. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-05-27 Roba M Talaat,Hiba Sibaii,Iman H Bassyouni,Amany El-Wakkad
There are a limited number of studies that report the polarization of the immune system toward the production of T helper 1 (Th1), Th2, or Th17-type cytokines in patients with Behçet’s disease (BD). Here, we aimed to detect the presence of various cytokines in serum samples of Egyptian BD patients and to determine the correlation between their production levels and clinical manifestations. To that
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Autoimmunity and cytokines in Guillain-Barré syndrome revisited: review of pathomechanisms with an eye on therapeutic options. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-05-27 Zahra Ebrahim Soltani,Farzaneh Rahmani,Nima Rezaei
Guillain-Barré syndrome (GBS) is the most common cause of acute paralysis in the United States. Campylobacter jejuni is a common trigger for GBS, igniting autoimmunity as a result of molecular mimicry between C. jejuni lipooligosaccharide (LOS) and host gangliosides. Evidence also suggests an active role for cell-mediated and innate immunity in pathogenesis of GBS. Infection alone is not enough for
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Elevated cytokine levels associated with acute kidney injury due to wasp sting. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-05-27 Fugang Li,Li Liu,Xiaolan Guo,Zhigang Luo,Yong Zhang,Feng Lu,Gang Wang,Tao Chen,Dezheng Chen
ObjectiveThis study mainly to explore the change of serum cytokines in wasp sting patients and the potential correlation between cytokines and acute kidney injury (AKI) due to wasp stings. MethodsThe levels of IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ in 33 wasp sting and 24 healthy people were measured by flow cytometry, the level of IL-17 was detected by enzyme-linked immunosorbent assay and the
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The role of inflammatory markers hs-CRP, sialic acid, and IL-6 in the pathogenesis of preeclampsia and intrauterine growth restriction. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-05-27 Ayse Ekin Kara,Gurhan Guney,Aytekin Tokmak,Gulnur Ozaksit
ObjectiveThe aim of our study was to evaluate serum high-sensitivity C-Reactive Protein (hs-CRP), sialic acid (SA), and interleukin-6 (IL-6) levels in pregnancies complicated with preeclampsia (PE) and intrauterine growth restriction (IUGR) and to compare with healthy pregnancies. Materials and MethodsThis study was conducted at a tertiary-level maternity hospital with 80 pregnant women. Fasting blood
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Assessment of an ultra-sensitive IFNγ immunoassay prototype for latent tuberculosis diagnosis. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-04-30 Elyes Ben Salah,Karim Dorgham,Mylène Lesénéchal,Camille Pease,Laure Allard,Céline Dragonetti,Guy Gorochov,Amélie Guihot,Delphine Sterlin
Worldwide there are about 1.7 billion individuals with latent tuberculosis infection (LTBI) and only 5% to 15% will develop active tuberculosis (TB). It is recommended to treat only those most at risk of developing active TB to avoid problems of drug resistance. LTBI diagnosis involves reviewing the individual’s medical history, physical examination, and biological tests. Interferon gamma release assays
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In vitro study of HAX1 gene therapy by retro viral transduction as a therapeutic target in severe congenital neutropenia. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-04-30 Hamid Farajifard,Mahdi Zavvar,Taraneh Rajaei,Farshid Noorbakhsh,Mahin Nikougoftar-Zarif,Kayhan Azadmanesh,Farzad Kompani,Nima Rezaei
Severe congenital neutropenia (SCN) is a primary immunodeficiency disease in which a number of underlying gene defects are responsible for abnormalities in neutrophil development. The HCLS1-associated protein X1 (HAX1) mutation is associated with an autosomal-recessive form of SCN. Considering the potential of gene therapy approaches for the treatment of monogenic disorders, in this study we aimed
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Toll-like receptors pathway in common variable immune deficiency (CVID) and X-linked agammaglobulinemia (XLA). Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-04-30 Parsova Tavasolian,Laleh Sharifi,Asghar Aghamohammadi,Farshid Noorbakhsh,Rouzbeh Sanaei,Mahsima Shabani,Nima Rezaei
Common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are two major humoral immunodeficiencies, causing a high rate of early age mortality in children. In order to identifiy the possible factors involved in the pathogenesis of CVID and XLA, recent studies have focused on Toll-like receptors (TLRs) and demonstrate the defects in different TLR pathways in immune cells of CVID
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RAC1 expression and role in IL-1β production and oxidative stress generation in familial Mediterranean fever (FMF) patients. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-04-30 José-Noel Ibrahim,Rania Jounblat,Nadine Jalkh,Joelle Abou Ghoch,Cynthia Al Hageh,Eliane Chouery,André Mégarbané,Jean-Claude Lecron,Myrna Medlej-Hashim
ObjectivesFamilial Mediterranean fever (FMF) is a recessively inherited autoinflammatory disorder. The caspase-1-dependent cytokine, IL-1β, plays an important role in FMF pathogenesis, and RAC1 protein has been recently involved in IL-1β secretion. This study aims to investigate RAC1 expression and role in IL-1β and caspase-1 production and oxidative stress generation in FMF. Materials and methodsThe
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Serum levels of transforming growth factor β1 and C-reactive protein as possible markers of intra uterine insemination outcome. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-04-30 Ayse Sahin,Yaprak Engin-Ustun,Aytekin Tokmak,Hasan Sahin,Salim Erkaya,A Seval Ozgu-Erdinc
ObjectiveMaternal immunity is important for the implantation phase, and exaggerated inflammatory responses may reduce the chance of implantation and pregnancy. Transforming growth factor β1 (TGF-β1) plays a role in the modulation of cellular growth, maturation and differentiation, extracellular matrix formation, immunoregulation, and apoptosis. In this study, we aimed to evaluate the changes in serum
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Increased IL-1β levels are associated with an imbalance of "oxidant/antioxidant" status during Behçet's disease. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-01-15 Arezki Chekaoui,Karima Lahmar,Houda Belguendouz,Fettoum Mazari,Malika Terahi,Djenette Hakem,Pierre Youinou,Chafia Touil-Boukoffa
BackgroundBehçet’s disease is a multisystem disease. It stands at the crossroad between the autoimmunity and auto-inflammatory disorders. In this study, we sought to address a relationship that might exist between interleukin-1β (IL-1β) and the oxidants/antioxidants markers in Behçet’s patients. MethodsBehçet’s disease patients (n = 78: active stage, n = 28; inactive stage, n = 50) and 41 healthy controls
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Obesity and inflammation. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-01-15 Jacek Karczewski,Ewelina Śledzińska,Alina Baturo,Izabela Jończyk,Aleksander Maleszko,Paweł Samborski,Beata Begier-Krasińska,Agnieszka Dobrowolska
The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes
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Elevated adiponectin and sTNFRII serum levels can predict progression to hepatocellular carcinoma in patients with compensated HCV1 cirrhosis. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-01-15 Jean-Philippe Bastard,Soraya Fellahi,Étienne Audureau,Richard Layese,Françoise Roudot-Thoraval,Carole Cagnot,Valérie Mahuas-Bourcier,Angela Sutton,Marianne Ziol,Jacqueline Capeau,Pierre Nahon,
Background and aimsAn obesity-related altered adipose tissue secretion is suggested as a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) cirrhosis. However, no prospective study has yet examined the predictive value of circulating adipokines and immuno-inflammatory biomarkers regarding this risk. MethodsThis was a case-control study nested in a prospective French
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Cytokines and male infertility. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-01-15 Vassiliki Syriou,Dimitrios Papanikolaou,Ariadni Kozyraki,Dimitrios G Goulis
Many male infertility cases have no apparent cause, being characterized as idiopathic. Both inflammation and obesity have long been associated with infertility. On one hand, inflammation, such as orchitis and male accessory gland infections (MAGIs), are regulated by inflammatory cytokines. The latter are also produced in the testis by Leydig and Sertoli cells, being associated with gap junctional communication
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Cytokine and molecular networks in sepsis cases: a network biology approach. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2019-01-15 Dong Wook Jekarl,Kyung Soo Kim,Seungok Lee,Myungshin Kim,Yonggoo Kim
BackgroundSepsis is a life-threatening condition of organ dysfunction caused by a dysregulated host immune response to infection. We performed network analysis of cytokine molecules and compared network structures between a systematic inflammatory response syndrome (SIRS) or normal control (NC) group and a sepsis group. ResultsWe recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic
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Characterization of new anti-IL-6 antibodies revealed high potency candidates for intracellular cytokine detection and specific targeting of IL-6 receptor binding sites. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-08-30 Karinna Chouman,Birgit Korioth-Schmitz,Markus Sack,Jörn Engelbert Schmitz,Anh Tuan Pham,Rainer Fischer,Stefan Barth,Torsten Klockenbring,Rolf Fendel
Interleukin-6 (IL-6) expression and secretion, induced by inflammatory processes, stimulate the acute phase response cascade. The overexpression of IL-6 contributes to a variety of inflammatory diseases, e.g. rheumatoid arthritis, Castleman’s disease, multiple myeloma, and prostate cancer. Screening for high amounts of IL-6 in the patients’ blood serum can be crucial for an adequate treatment. In this
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Role of IL-18 in transplant biology. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-08-30 Chen Liu,Juntao Chen,Baoqing Liu,Shunzong Yuan,Dawei Shou,Liang Wen,Xiaoying Wu,Weihua Gong
Since pro-inflammatory cytokine IL-18 and its receptor (IL-18R) are closely involved in regulating both adaptive and innate immune responses, it is conceivable that they might play an important role in organ transplantation. IL-18 can stimulate lymphocytes to produce the IFN-γ and regulate macrophage activity, thereby increasing the expression of proinflammatory cytokines including IL-1β, IL-6, CCL4
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Clinical significance of serum leptin level in patients with gastric cancer. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-08-30 Faruk Tas,Senem Karabulut,Kayhan Erturk,Derya Duranyildiz
Leptin may support the proliferation and hinder the apoptosis of tumor cells. Although leptin expression has been studied in several human tumors, its potential clinical significance remains uncertain in patients with gastric carcinoma. Furthermore, the majority of available findings have been determined from preclinical studies using stomach carcinoma tissue section and, to date, few studies have
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The prognostic time dependence of intra-tumoural IFNγ mRNA and protein in patients with breast cancer followed for 14 years after surgery and radiotherapy, without subsequent systemic therapy. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-06-20 Nataša Todorović-Raković,Marko Radulovic,Tijana Vujasinović,Jelena Milovanović,Dragica Nikolić-Vukosavljević
There is increasing evidence for the importance of immunity in breast cancer. IFNγ is expected to have a prognostic value based on its major role in innate and specific cell-mediated immunity. In this retrospective study, based on the 14-year follow-up of 73 patients with breast cancer after surgery and radiotherapy but no subsequent systemic therapy, we investigated the prognostic time dependence
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Seminal plasma adipokines: involvement in human reproductive functions. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-06-20 Yaelle Elfassy,Chloe McAvoy,Soraya Fellahi,Joëlle Dupont,Bruno Fève,Rachel Levy,Jean-Philippe Bastard
Infertility, which increased worldwide over the past few decades, has recently been linked to obesity prevalence. Adipokines, produced by adipose tissue, could be the link between obesity and infertility. The association between circulating adipokines and female infertility has been extensively studied in the last ten years. However, the male aspect has been less investigated, although some adipokines
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Interleukin-18: a regulator of cancer and autoimmune diseases. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-06-20 Maryam Esmailbeig,Abbas Ghaderi
Interleukin (IL)-18, structurally similar to IL-1-, is a member of IL-1 superfamily of cytokines. This cytokine, which is expressed by many human lymphoid and nonlymphoid cells, has an important role in inflammatory processes. The main function of IL-18 is mediated through induction of interferon-γ (IFN-γ) secretion from T helper (Th1) cells. This cytokine synergistically with IL-12 contributes to
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Interleukin-32 plays an essential role in human calcified aortic valve cells. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-05-18 Chung-Lin Tsai,Ying-Ming Chiu,Yi-Ju Lee,Chin-Tung Hsieh,Dong-Chen Shieh,Gregory J Tsay,Da-Tian Bau,Yi-Ying Wu
Interleukin-32 (IL-32) is an inflammatory cytokine produced mainly by T, natural killer, and epithelial cells. Previous studies on IL-32 have primarily investigated its proinflammatory properties. The IL-32 also has been described as an activator of the p38 mitogen-activated protein kinase (MAPK) and NF-κB, and induces several cytokines. In this study, we hypothesized that the inflammatory regulators
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Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-05-18 Sara Harsini,Amene Saghazadeh,Saharnaz Nedjat,Nima Rezaei
BackgroundCytokine genes, including interleukin-10 (IL-10), are known to play important roles in the pathogenesis of juvenile idiopathic arthritis (JIA). This study aims to determine whether the IL-10 polymorphisms confer susceptibility to JIA. MethodsA meta-analysis was performed on the associations between the IL-10-1082 G/A, -592 C/A, and -819 C/T polymorphisms and JIA. A total number of 7 studies
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TL1A mediates fibroblast-like synoviocytes migration and Indian Hedgehog signaling pathway via TNFR2 in patients with rheumatoid arthritis. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-05-18 Mahmoud Al-Azab,Jing Wei,Xunli Ouyang,Abdalkhalig Elkhider,Williams Walana,Xiaotong Sun,Yawei Tang,Bing Wang,Xia Li
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine 1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and
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Interleukin-6 and cardiac operations. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2018-05-18 Shi-Min Yuan
Interleukin (IL)-6 is a pleiotropic inflammatory cytokine with both pro- and anti-inflammatory capacities, produced by different cells and tissues, such as leukocytes, adipocytes, and endothelium. From the viewpoint of cardiologists, this cytokine is a reliable biomarker of cardiac dysfunction, occurrence of atrial fibrillation, cardiac myxoma with recurrence, remote metastasis or embolization, and
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Enzyme-Linked Immunosorbent Spot (ELISpot) monitoring of cytokine-producing cells for the prediction of acute rejection in renal transplant patients. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2017-12-12 Fatemeh Mohammadi,Ghasem Solgi,Maryam Tajik,Pedram Ahmadpoor,Hasan Nikoeinejad,Behzad Einollahi,Banafsheh Nazari,Mahboob Lessan-Pezeshki,Aliakbar Amirzargar
The purpose of this study was to evaluate T-cell immunity markers using serial post-transplantation monitoring of cytokine-producing cells during the first post-transplant months for the prediction of acute rejection and potentially chronic rejection of kidney allograft. We followed 57 kidney allograft recipients for meanly 3 years post-transplantation. Blood samples were collected pre-transplant,
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Sophocarpine suppress inflammatory response in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2017-12-12 Lihua Zhu,Liyan Zhu
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disease affecting nearly 1% of adults worldwide. This study aimed to investigate whether sophocarpine is a potential drug for treating RA. MethodsThe cytotoxicity of sophocarpine to RA-fibroblast-like synoviocytes (FLSs) was evaluated using 3-[4,-dimethylthiazol-2-y]-2,5-diphenyl-tetrazolium bromide (MTT) assays kit and released lactate dehydrogenase
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Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2017-12-12 José L Aparicio,Macarena Ottobre,Maite Duhalde Vega,Jean-Paul Coutelier,Jacques Van Snick,Lilia A Retegui
Mice infected with mouse hepatitis virus A59 (MHV-A59) develop hepatitis and autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH), a fact closely related to the release of alarmins such as uric acid and/or high-mobility group box protein 1 (HMGB1). We studied the effect of neutralizing monoclonal antibodies (MAb) against IL-17A in our model of mouse MHV-A59-infection. MAb
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PRR signaling during in vitro macrophage differentiation from progenitors modulates their subsequent response to inflammatory stimuli. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2017-12-12 Alba Martínez,Cristina Bono,Javier Megías,Alberto Yáñez,Daniel Gozalbo,M Luisa Gil
Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to differentiate along the myeloid lineage in vitro and also in vivo following infection. In this study, we used an in vitro model of HSPC differentiation to investigate the functional consequences (cytokine production) that exposing HSPCs to various pathogen-associated molecular patterns (PAMPs) and Candida albicans
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Buprenorphine differentially affects M1- and M2-polarized macrophages from human umbilical cord blood. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2017-08-08 Juan Sun,Wei Guo,Xingguang Du
BackgroundAs a partial μ-opioid receptor agonist with long half-life time, buprenorphine has been widely used to relieve chronic cancer and nonmalignant pain. The maintenance of chronic pain involves inflammation; however whether buprenorphine has anti-inflammation property remains unclear. MethodsMacrophages, the immune cells that initiate and maintain inflammation, were isolated from human umbilical
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The role of host immune cells and Borrelia burgdorferi antigens in the etiology of Lyme disease. Eur. Cytokine Netw. (IF 1.912) Pub Date : 2017-08-08 Dennis Verhaegh,Leo A B Joosten,Marije Oosting
Lyme disease is a zoonosis caused by infection with bacteria belonging to the Borrelia burgdorferi species after the bite of an infected tick. Even though an infection by this bacterium can be effectively treated with antibiotics, when the infection stays unnoticed B. burgdorferi can persist and chronic post-treatment Lyme disease syndrome is able to develop. Although a cellular and humoral response
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