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Mitophagy defect mediates the aging‐associated hallmarks in Hutchinson–Gilford progeria syndrome Aging Cell (IF 7.8) Pub Date : 2024-03-14 Yingying Sun, Le Xu, Yi Li, Shunze Jia, Gang Wang, Xufeng Cen, Yuyan Xu, Zhongkai Cao, Jingjing Wang, Ning Shen, Lidan Hu, Jin Zhang, Jianhua Mao, Hongguang Xia, Zhihong Liu, Xudong Fu
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The aged microenvironment impairs BCL6 and CD40L induction in CD4+ T follicular helper cell differentiation Aging Cell (IF 7.8) Pub Date : 2024-03-14 Jacob S. Fisher, Irene Adán‐Barrientos, Naveen R. Kumar, Jessica N. Lancaster
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Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila Aging Cell (IF 7.8) Pub Date : 2024-03-14 Mariann M. Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E. Fairman, Anne Le, Ginger L. Milne, Fernando J. Vonhoff, Jeremy D. Walston, Peter M. Abadir
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Dermal stiffness governs the topography of the epidermis and the underlying basement membrane in young and old human skin Aging Cell (IF 7.8) Pub Date : 2024-03-13 Eva Roig‐Rosello, Guila Dayan, Simone Bovio, Patricia Manissier, Elisabeth Errazuriz, Patricia Rousselle
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Endothelial‐specific telomerase inactivation causes telomere‐independent cell senescence and multi‐organ dysfunction characteristic of aging Aging Cell (IF 7.8) Pub Date : 2024-03-13 Zhanguo Gao, Rafael Bravo Santos, Joseph Rupert, Rachel Van Drunen, Yongmei Yu, Kristin Eckel‐Mahan, Mikhail G. Kolonin
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Featured Cover Aging Cell (IF 7.8) Pub Date : 2024-03-12 Yoon Seon Lee, Yeoung‐Hyun Park, Geumbit Hwang, Hyejin Seo, Si Hyoung Ki, Shengfeng Bai, Chul Son, Seong Min Roh, Su‐Jin Park, Dong‐Seol Lee, Ji‐Hyun Lee, You‐Mi Seo, Won Jun Shon, Daehyun Jeon, Mi Jang, Sahng G. Kim, Byoung‐Moo Seo, Gene Lee, Joo‐Cheol Park
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Additional Cover Aging Cell (IF 7.8) Pub Date : 2024-03-12 Chaweewan Sirakawin, Dongfa Lin, Ziyue Zhou, Xiaoxin Wang, Rhianne Kelleher, Shangyuan Huang, Weimiao Long, Andre Pires‐daSilva, Yu Liu, Jingjing Wang, Ilya A. Vinnikov
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Additional Cover Aging Cell (IF 7.8) Pub Date : 2024-03-12 Seungman Park, Thomas C. Laskow, Jingchun Chen, Prasun Guha, Buddhadeb Dawn, Deok‐Ho Kim
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Correction to: Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1‐mediated autophagy regulation Aging Cell (IF 7.8) Pub Date : 2024-03-12
Ren J, Yang L, Zhu L, Xu X, Ceylan AF, Guo W, Yang J, Zhang Y. Aging Cell. 2017;16(5):976-987. doi: https://doi.org/10.1111/acel.12616. Epub 2017 Jul 5. The authors of the abovementioned paper noticed an error in Figure 1 as reported. During data analysis of lectin staining, several data points were mistakenly entered twice causing erroneously reported sample size, mean, and SEM. We have corrected
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Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan Aging Cell (IF 7.8) Pub Date : 2024-03-11 Gillian Borland, Stephen E. Wilkie, Jackie Thomson, Zhe Wang, Jennifer M. A. Tullet, Nazif Alic, Colin Selman
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Chronic TNF exposure induces glucocorticoid‐like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia Aging Cell (IF 7.8) Pub Date : 2024-03-09 Katherine L. Kruckow, Elizabeth Murray, Elnur Shayhidin, Alexander F. Rosenberg, Dawn M. E. Bowdish, Carlos J. Orihuela
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A molecular index for biological age identified from the metabolome and senescence‐associated secretome in humans Aging Cell (IF 7.8) Pub Date : 2024-03-08 Shruthi Hamsanathan, Tamil Anthonymuthu, Denise Prosser, Anna Lokshin, Susan L. Greenspan, Neil M. Resnick, Subashan Perera, Satoshi Okawa, Giri Narasimhan, Aditi U. Gurkar
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Integrin restriction by miR‐34 protects germline progenitors from cell death during aging Aging Cell (IF 7.8) Pub Date : 2024-03-07 Noam Perry, Racheli Braun, Aya Ben‐Hamo‐Arad, Diana Kanaan, Tal Arad, Lilach Porat‐Kuperstein, Toledano Hila
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Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response Aging Cell (IF 7.8) Pub Date : 2024-03-07 Janette van der Linden, Sanne J. M. Stefens, José María Heredia‐Genestar, Yanto Ridwan, Renata M. C. Brandt, Nicole van Vliet, Isa de Beer, Bibi S. van Thiel, Herman Steen, Caroline Cheng, Anton J. M. Roks, A. H. Jan Danser, Jeroen Essers, Ingrid van der Pluijm
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Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner Aging Cell (IF 7.8) Pub Date : 2024-03-07 Xihan Guo, Jianfei Li, Yanmei Qi, Juanlin Chen, Minyan Jiang, Lina Zhu, Zetong Liu, Han Wang, Gongwu Wang, Xu Wang
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Plasma proteomic signature of human longevity Aging Cell (IF 7.8) Pub Date : 2024-03-05 Xiaojuan Liu, Gisli Thor Axelsson, Anne B. Newman, Bruce M. Psaty, Robert M. Boudreau, Chenkai Wu, Alice M. Arnold, Thor Aspelund, Thomas R. Austin, Julius M. Gardin, Kristin Siggeirsdottir, Russell P. Tracy, Robert E. Gerszten, Lenore J. Launer, Lori L. Jennings, Vilmundur Gudnason, Jason L. Sanders, Michelle C. Odden
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Epigenetic aging of human blood cells is influenced by the age of the host body Aging Cell (IF 7.8) Pub Date : 2024-03-05 Petter Holland, Mette Istre, Maryan M. Ali, Tobias Gedde‐Dahl, Jochen Buechner, Mari Wildhagen, Sonja H. Brunvoll, Steve Horvath, Shigemi Matsuyama, John Arne Dahl, Friedrich Stölzel, Arne Søraas
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Multi‐proteomic analyses of 5xFAD mice reveal new molecular signatures of early‐stage Alzheimer's disease Aging Cell (IF 7.8) Pub Date : 2024-03-04 Seulah Lee, Kuk‐In Jang, Hagyeong Lee, Yeon Suk Jo, Dayoung Kwon, Geuna Park, Sungwon Bae, Yang Woo Kwon, Jin‐Hyeok Jang, Yong‐Seok Oh, Chany Lee, Jong Hyuk Yoon
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The cellular bases of mobility from the Study of Muscle, Mobility and Aging (SOMMA) Aging Cell (IF 7.8) Pub Date : 2024-03-02 Steven R. Cummings, Paul M. Coen, Luigi Ferrucci
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Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden Aging Cell (IF 7.8) Pub Date : 2024-03-01 Thaís Lopes De Oliveira, Bowen Tang, Ge Bai, Arvid Sjölander, Juulia Jylhävä, Deborah Finkel, Nancy L. Pedersen, Linda B. Hassing, Chandra A. Reynolds, Ida K. Karlsson, Sara Hägg
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Transcriptomic and intervention evidence reveals domestic dogs as a promising model for anti‐inflammatory investigation Aging Cell (IF 7.8) Pub Date : 2024-03-01 Min Zeng, Tong Zhou, Zhiyu Li, Guimei Li, Shurun Zhang, Lu Wang, Qing‐Guo Huang, Ju‐Dong Li, P. Nadeeshika Samarawickrama, Yonghan He, Guo‐Dong Wang
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Inhibition of 26S proteasome activity by α‐synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1 Aging Cell (IF 7.8) Pub Date : 2024-02-28 Dajana Galka, Tariq T. Ali, Alexander Bast, Marie Niederleithinger, Ellen Gerhardt, Ryo Motosugi, Eri Sakata, Michael Knop, Tiago F. Outeiro, Blagovesta Popova, Gerhard H. Braus
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Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D‐galactose‐induced accelerated aging mice Aging Cell (IF 7.8) Pub Date : 2024-02-28 Bin Wang, Wenpei Yu, Weiguang Zhang, Min Zhang, Yue Niu, Xinye Jin, Jie Zhang, Ding Sun, Hao Li, Zehao Zhang, Qing Luo, Xiaowei Cheng, Jingxue Niu, Guangyan Cai, Xiangmei Chen, Yizhi Chen
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Epigenome‐wide analysis of frailty: Results from two European twin cohorts Aging Cell (IF 7.8) Pub Date : 2024-02-28 Jonathan K. L. Mak, Asmus Cosmos Skovgaard, Marianne Nygaard, Laura Kananen, Chandra A. Reynolds, Yunzhang Wang, Ralf Kuja‐Halkola, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg, Mette Soerensen, Juulia Jylhävä
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Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness Aging Cell (IF 7.8) Pub Date : 2024-02-28 Ferenc Torma, Csaba Kerepesi, Mátyás Jókai, Gergely Babszki, Erika Koltai, Balázs Ligeti, Regina Kalcsevszki, Kristen M. McGreevy, Steve Horvath, Zsolt Radák
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Histone deficiency and hypoacetylation in the aging retinal pigment epithelium Aging Cell (IF 7.8) Pub Date : 2024-02-26 Sushil K. Dubey, Rashmi Dubey, Subhash C. Prajapati, Kyungsik Jung, Kabhilan Mohan, Xinan Liu, Jacob Roney, Wenjian Tian, Jennifer Abney, Michelle M. Giarmarco, Alvaro G. Hernandez, Jinze Liu, Mark E. Kleinman
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S100A8‐enriched microglia populate the brain of tau‐seeded and accelerated aging mice Aging Cell (IF 7.8) Pub Date : 2024-02-26 Roxane Gruel, Baukje Bijnens, Johanna Van Den Daele, Sofie Thys, Roland Willems, Dirk Wuyts, Debby Van Dam, Peter Verstraelen, Rosanne Verboven, Jana Roels, Niels Vandamme, Renzo Mancuso, Juan Diego Pita‐Almenar, Winnok H. De Vos
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Advanced age and female sex protect cerebral arteries from mitochondrial depolarization and apoptosis during acute oxidative stress Aging Cell (IF 7.8) Pub Date : 2024-02-21 Charles E. Norton, Rebecca L. Shaw, Safa, Beyoncé Dockery, Timothy L. Domeier, Steven S. Segal
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Genome‐wide profiles of DNA damage represent highly accurate predictors of mammalian age Aging Cell (IF 7.8) Pub Date : 2024-02-23 Huifen Cao, Bolin Deng, Tianrong Song, Jiabian Lian, Lu Xia, Xiaojing Chu, Yufei Zhang, Fujian Yang, Chunlian Wang, Ye Cai, Yong Diao, Philipp Kapranov
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N‐homocysteinylation of DJ‐1 promotes neurodegeneration in Parkinson's disease Aging Cell (IF 7.8) Pub Date : 2024-02-21 Tao Guo, Lingyan Zhou, Min Xiong, Jing Xiong, Juan Huang, Yiming Li, Guoxin Zhang, Guiqin Chen, Zhi‐Hao Wang, Tingting Xiao, Dan Hu, Anyu Bao, Zhentao Zhang
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Metabolomic age and risk of 50 chronic diseases in community‐dwelling adults: A prospective cohort study Aging Cell (IF 7.8) Pub Date : 2024-02-21 Xianwen Shang, Jiahao Liu, Zhuoting Zhu, Xueli Zhang, Yu Huang, Shunming Liu, Wei Wang, Xiayin Zhang, Shuo Ma, Shulin Tang, Yijun Hu, Zongyuan Ge, Honghua Yu, Mingguang He
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Age‐related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging Aging Cell (IF 7.8) Pub Date : 2024-02-21 Nadia S. Kurochkina, Mira A. Orlova, Maksim A. Vigovskiy, Viktor G. Zgoda, Tatiana F. Vepkhvadze, Nikita E. Vavilov, Pavel A. Makhnovskii, Olga A. Grigorieva, Yakov R. Boroday, Vladislav V. Philippov, Egor M. Lednev, Anastasia Yu. Efimenko, Daniil V. Popov
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METTL14 affects UVB‐induced human dermal fibroblasts photoaging via miR‐100‐3p biogenesis in an m6A‐dependent manner Aging Cell (IF 7.8) Pub Date : 2024-02-21 Lihao Chen, Yu Hu, Min Zhang, Lihao Liu, Jing Ma, Zhuohong Xu, Jiaan Zhang, Heng Gu, Kun Chen
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HuR-positive stress granules: Potential targets for age-related osteoporosis Aging Cell (IF 7.8) Pub Date : 2024-02-20 Ying Huai, Xue Wang, Wenjing Mao, Xuehao Wang, Yipu Zhao, Xiaohua Chu, Qian Huang, Kang Ru, Ling Zhang, Yu Li, Zhihao Chen, Airong Qian
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Spatially resolved transcriptome of the aging mouse brain Aging Cell (IF 7.8) Pub Date : 2024-02-19 Cheng Wu, Tianxiang Tu, Mingzhe Xie, Yiting Wang, Biao Yan, Yajun Gong, Jiayi Zhang, Xiaolai Zhou, Zhi Xie
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Mitochondrial S-adenosylmethionine deficiency induces mitochondrial unfolded protein response and extends lifespan in Caenorhabditis elegans Aging Cell (IF 7.8) Pub Date : 2024-02-15 Tse Yu Chen, Feng-Yung Wang, Pin-Jung Lee, Ao-Lin Hsu, Tsui-Ting Ching
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Homocysteine potentiates amyloid β-induced death receptor 4- and 5-mediated cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment Aging Cell (IF 7.8) Pub Date : 2024-02-15 Ashley Carey, Rebecca Parodi-Rullan, Rafael Vazquez-Torres, Elisa Canepa, Silvia Fossati
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Nucleoporin93 limits Yap activity to prevent endothelial cell senescence Aging Cell (IF 7.8) Pub Date : 2024-02-13 Tung D. Nguyen, Mihir K. Rao, Shaiva P. Dhyani, Justin M. Banks, Michael A. Winek, Julia Michalkiewicz, Monica Y. Lee
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Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster Aging Cell (IF 7.8) Pub Date : 2024-02-11 Analisa L. Taylor, Olga Dubuisson, Pritika Pandey, Elizabeth R. M. Zunica, Bolormaa Vandanmagsar, Wagner S. Dantas, Alyssa Johnson, Christopher L. Axelrod, John P. Kirwan
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Featured Cover Aging Cell (IF 7.8) Pub Date : 2024-02-12 Ngoc Luu, Apratim Bajpai, Rui Li, Seojin Park, Mahad Noor, Xiao Ma, Weiqiang Chen
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Additional Cover Aging Cell (IF 7.8) Pub Date : 2024-02-12 Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Takashi Nakashima, Shoko Okuda, Yoshitaka Manabe, Shoko Sawano, Wataru Mizunoya, Ryuki Kaneko, Sakiho Tanaka, Takahiro Maeno, Yuji Matsuyoshi, Miyumi Seki, So Kuwakado, Kahona Zushi, Nasibeh Daneshvar, Mako Nakamura, Takahiro Suzuki, Kenji Sunagawa, Judy E. Anderson, Ronald E. Allen, Ryuichi Tatsumi
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Aging clock based on nucleosome reorganisation derived from cell-free DNA Aging Cell (IF 7.8) Pub Date : 2024-02-09 Mariya Shtumpf, Seihee Jeong, Milena Bikova, Hulkar Mamayusupova, Luminita Ruje, Vladimir B. Teif
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Restoration of norepinephrine release, cognitive performance, and dendritic spines by amphetamine in aged rat brain Aging Cell (IF 7.8) Pub Date : 2024-02-08 Serena Scognamiglio, Yousef M. Aljohani, Thao T. Olson, Patrick A. Forcelli, Ghazaul Dezfuli, Kenneth J. Kellar
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Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA) Aging Cell (IF 7.8) Pub Date : 2024-02-08 Nicholas J. Day, Shane S. Kelly, Li-Yung Lui, Tyler A. Mansfield, Matthew J. Gaffrey, Jesse B. Trejo, Tyler J. Sagendorf, Isaac K. Attah, Ronald J. Moore, Collin M. Douglas, Anne B. Newman, Stephen B. Kritchevsky, Philip A. Kramer, David J. Marcinek, Paul M. Coen, Bret H. Goodpaster, Russell T. Hepple, Peggy M. Cawthon, Vladislav A. Petyuk, Karyn A. Esser, Wei-Jun Qian, Steven R. Cummings
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Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults Aging Cell (IF 7.8) Pub Date : 2024-02-05 Vanda W. T. Ho, Low Heng Boon, Jianzhou Cui, Zhou Juequn, Bhuvaneshwari Shunmuganathan, Rashi Gupta, Nikki Y. J. Tan, Xinlei Qian, Kiren Purushotorman, , Siew-Wai Fong, Laurent Renia, Lisa F. P. Ng, Veronique Angeli, Jinmiao Chen, Brian K. Kennedy, Catherine W. M. Ong, Paul A. Macary
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The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons Aging Cell (IF 7.8) Pub Date : 2024-02-01 Taylor Russo, Benjamin Kolisnyk, Aswathy B. S., Jonathan Plessis-Belair, Tae Wan Kim, Jacqueline Martin, Jason Ni, Jordan A. Pearson, Emily J. Park, Roger B. Sher, Lorenz Studer, Markus Riessland
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Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging Aging Cell (IF 7.8) Pub Date : 2024-01-29 Haojue Wang, Tao Yuan, Yi Wang, Changxing Liu, Dengju Li, Ziqing Li, Shui Sun
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Implications of metabolism on multi-systems healthy aging across the lifespan Aging Cell (IF 7.8) Pub Date : 2024-01-29 Shanshan Yao, Laura A. Colangelo, Andrew S. Perry, Megan M. Marron, Kristine Yaffe, Sanaz Sedaghat, Joao A. C. Lima, Qu Tian, Clary B. Clish, Anne B. Newman, Ravi V. Shah, Venkatesh L. Murthy
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Vitamin D3 inhibits p38 MAPK and senescence-associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing Aging Cell (IF 7.8) Pub Date : 2024-01-29 Souraya Sayegh, Carlos H. Fantecelle, Phatthamon Laphanuwat, Priya Subramanian, Malcom H. A. Rustin, Daniel O. Gomes, Arne N. Akbar, Emma S. Chambers
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Correction to “A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo” Aging Cell (IF 7.8) Pub Date : 2024-01-29
Samir Morsli, Catarina M. Henriques, Pamela S. Ellis, Heather Mortiboys, Sarah Baxendale, Catherine A. Loynes, Stephen A. Renshaw, Ilaria Bellantuono. 2023;22:6:e13835. In Figure 4g, the bottom left hand graph is a duplication of the graph on the bottom right. Below is the version of this figure with the correct graphs. We apologize for this error.
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Daily activity profiles over the lifespan of female medflies as biomarkers of aging and longevity Aging Cell (IF 7.8) Pub Date : 2024-01-24 Han Chen, Hans-Georg Müller, Vasilis G. Rodovitis, Nikos T. Papadopoulos, James R. Carey
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Long term methionine restriction: Influence on gut microbiome and metabolic characteristics Aging Cell (IF 7.8) Pub Date : 2024-01-26 Akash Nagarajan, Alexander Tate Lasher, Casey D. Morrow, Liou Y. Sun
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Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics Aging Cell (IF 7.8) Pub Date : 2024-01-24 Andi Zhang, Yi Pan, Hao Wang, Rui Ding, Tianyuan Zou, Dongye Guo, Yilin Shen, Peilin Ji, Weiyi Huang, Qing Wen, Quan Wang, Haixia Hu, Jichang Wu, Mingliang Xiang, Bin Ye
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DNA methylation and chromatin accessibility predict age in the domestic dog Aging Cell (IF 7.8) Pub Date : 2024-01-23 Kelly Jin, Brianah M. McCoy, Elisabeth A. Goldman, Viktoria Usova, Victor Tkachev, Alex D. Chitsazan, Anneke Kakebeen, Unity Jeffery, Kate E. Creevy, Andrea Wills, Noah Snyder-Mackler, Daniel E. L. Promislow
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L-arginine metabolism ameliorates age-related cognitive impairment by Amuc_1100-mediated gut homeostasis maintaining Aging Cell (IF 7.8) Pub Date : 2024-01-18 Jiamin He, Tongyao Hou, Qiwen Wang, Qingyi Wang, Yao Jiang, Luyi Chen, Jilei Xu, Yadong Qi, Dingjiacheng Jia, Yanrou Gu, Lidan Gao, Yingcong Yu, Lan Wang, Lijun Kang, Jianmin Si, Liangjing Wang, Shujie Chen
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Glioblastoma and its treatment are associated with extensive accelerated brain aging Aging Cell (IF 7.8) Pub Date : 2024-01-17 Anna P. Ainslie, Myrthe Klaver, Daniëlle C. Voshart, Emma Gerrits, Wilfred F. A. den Dunnen, Bart J. L. Eggen, Steven Bergink, Lara Barazzuol
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Synergistic interplay of UV radiation and urban particulate matter induces impairment of autophagy and alters cellular fate in senescence-prone human dermal fibroblasts Aging Cell (IF 7.8) Pub Date : 2024-01-12 Lena Guerrero-Navarro, Pidder Jansen-Dürr, Maria Cavinato
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Correlates of life course physical activity in participants of the Baltimore longitudinal study of aging Aging Cell (IF 7.8) Pub Date : 2024-01-16 Ann Zenobia Moore, Eleanor M. Simonsick, Bennett Landman, Jennifer Schrack, Amal A. Wanigatunga, Luigi Ferrucci