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The role of cardiac microenvironment in cardiovascular diseases: implications for therapy Hum. Cell (IF 4.3) Pub Date : 2024-03-18 Jiayu Yao, Yuejun Chen, Yuqing Huang, Xiaoou Sun, Xingjuan Shi
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Establishment and characterization of NCC-ASPS2-C1: a novel patient-derived cell line of alveolar soft part sarcoma Hum. Cell (IF 4.3) Pub Date : 2024-03-13 Julia Osaki, Rei Noguchi, Kazuyoshi Yanagihara, Takuya Ono, Yuki Adachi, Shuhei Iwata, Yu Toda, Tetsuya Sekita, Eisuke Kobayashi, Naoki Kojima, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
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Lactate in breast cancer cells is associated with evasion of hypoxia-induced cell cycle arrest and adverse patient outcome Hum. Cell (IF 4.3) Pub Date : 2024-03-13 Yamin Liu, Yasir Suhail, Ashkan Novin, Junaid Afzal, Aditya Pant, Kshitiz
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Anexelekto (AXL) no more: microRNA-155 (miR-155) controls the “Uncontrolled” in SARS-CoV-2 Hum. Cell (IF 4.3) Pub Date : 2024-03-12 K. I. Papadopoulos, A. Papadopoulou, T. C. Aw
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Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone: NCC-GCTB8-C1 and NCC-GCTB9-C1 Hum. Cell (IF 4.3) Pub Date : 2024-03-11 Yuki Adachi, Rei Noguchi, Yuki Yoshimatsu, Yooksil Sin, Julia Osaki, Takuya Ono, Shuhei Iwata, Taro Akiyama, Ryuto Tsuchiya, Yu Toda, Shin Ishihara, Koichi Ogura, Eisuke Kobayashi, Naoki Kojima, Akihiko Yoshida, Hideki Yokoo, Akira Kawai, Tadashi Kondo
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Liraglutide prevents cellular senescence in human retinal endothelial cells (HRECs) mediated by SIRT1: an implication in diabetes retinopathy Hum. Cell (IF 4.3) Pub Date : 2024-03-04 Lihua Hou, Jianying Du, Yongxiao Dong, Min Wang, Libo Wang, Jifei Zhao
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Transcription factors in chimeric antigen receptor T-cell development Hum. Cell (IF 4.3) Pub Date : 2024-03-04
Abstract Chimeric antigen receptor (CAR) T-cell therapy is a new and innovative approach to treating cancers that has shown promising results in the treatment of lymphoma. However, it has been found to be less effective in the treatment of solid tumors. To overcome the limitation, researchers have explored the use of combined CAR-T therapy with other complementary regimens that target specific genes
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Protein regulator of cytokinesis 1 accentuates cholangiocarcinoma progression via mTORC1-mediated glycolysis Hum. Cell (IF 4.3) Pub Date : 2024-02-28
Abstract This study aimed to investigate the expression of protein regulator of cytokinesis 1 (PRC1) in cholangiocarcinoma (CHOL) and elucidate its potential impact as well as the underlying mechanisms governing the progression of CHOL. In this study, we used CHOL cells (HUCCT1, RBE, and CCLP1) and conducted a series of experiments, including qRT-PCR, cell counting kit-8 assays, EdU assays, flow cytometry
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Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation Hum. Cell (IF 4.3) Pub Date : 2024-02-28 Meng Wang, Qiu-Jie Li, Hua-Yan Zhao, Jing-Lan Zhang
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MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas Hum. Cell (IF 4.3) Pub Date : 2024-02-27 Divya Mohan, Aruna Nambirajan, Rafat Malik, Agrima Sharma, Vaishali Suri, Kavneet Kaur, Ramesh Doddamani, Ajay Garg, Subhash Gupta, Supriya Mallick, Mehar Chand Sharma
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Saracatinib prompts hemin-induced K562 erythroid differentiation but suppresses erythropoiesis of hematopoietic stem cells Hum. Cell (IF 4.3) Pub Date : 2024-02-22 Lina Ding, Diyu Chen, Yuanshuai Li, Yingjun Xie, Xiaofang Sun, Ding Wang
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Wnt, notch signaling and exercise: what are their functions? Hum. Cell (IF 4.3) Pub Date : 2024-02-22 Yijie Zhao, Guangjun Wang, Zhifeng Wei, Duo Li, Mohammadamin Morshedi
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Identification of a family with van der Hoeve’s syndrome harboring a novel COL1A1 mutation and generation of patient-derived iPSC lines and CRISPR/Cas9-corrected isogenic iPSCs Hum. Cell (IF 4.3) Pub Date : 2024-02-20 SiJun Li, Lingyun Mei, Chufeng He, Xinzhang Cai, Hong Wu, XueWen Wu, Yalan Liu, Yong Feng, Jian Song
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Establishment and characterization of ZJUCHi003: an induced pluripotent stem cell line from a patient with Temple–Baraitser/Zimmermann–Laband syndrome carrying KCNH1 c.1070G > A (p.R357Q) variant Hum. Cell (IF 4.3) Pub Date : 2024-02-19 Die Chen, Jimei Su, Xueying Huang, Hongyu Chen, Tiejia Jiang, Chunchun Zhi, Zuolin Zhou, Bing Zhang, Lan Yu, Xiaoling Jiang
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Establishment and characterization of NCC-DFSP5-C1: a novel patient-derived dermatofibrosarcoma protuberans cell line Hum. Cell (IF 4.3) Pub Date : 2024-02-19 Takuya Ono, Rei Noguchi, Julia Osaki, Taro Akiyama, Yuki Adachi, Naoki Kojima, Yu Toda, Suguru Fukushima, Yuki Yoshimatsu, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
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Prognostic significance and immune escape implication of tumor-infiltrating neutrophil plasticity in human head and neck squamous cell carcinoma Hum. Cell (IF 4.3) Pub Date : 2024-02-15
Abstract Tumor-infiltrating neutrophils play a crucial role in the progression of head and neck squamous cell carcinoma (HNSCC). Here, we aimed to statistically quantify the plasticity of HNSCC-infiltrating N2/N1 neutrophils and examine its impacts on survival and immune infiltration landscape. A retrospective study of 80 patients who underwent curative surgical resection for HNSCC between 2014 and
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Targeting cholesterol biosynthesis for AT/RT: comprehensive expression analysis and validation in newly established AT/RT cell line Hum. Cell (IF 4.3) Pub Date : 2024-02-08 Fumitaka Matsumoto, Kiyotaka Yokogami, Ai Yamada, Hiroshi Moritake, Takashi Watanabe, Shinji Yamashita, Yuichiro Sato, Hideo Takeshima
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Role of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction Hum. Cell (IF 4.3) Pub Date : 2024-02-05 Lingling Jing, Kexin Liu, Feng Wang, Ying Su
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Glycolysis Modulation by METTL7B Shapes Acute Lymphoblastic Leukemia Cell Proliferation and Chemotherapy Response Hum. Cell (IF 4.3) Pub Date : 2024-01-31
Abstract Acute lymphoblastic leukemia (ALL) is a devastating hematological malignancy characterized by uncontrolled proliferation of immature lymphoid cells. While advances in treatment have improved patient outcomes, challenges remain in enhancing therapeutic efficacy and understanding underlying molecular mechanisms. Methyltransferase-like 7B (METTL7B), known for its methyltransferase activity, has
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Establishment and characterization of a novel hypopharyngeal squamous cell carcinoma cell line CZH1 with genetic abnormalities Hum. Cell (IF 4.3) Pub Date : 2024-01-27 Jingyu Ma, Xiaoke Zhu, Yu Heng, Xuping Ding, Lei Tao, Liming Lu
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PDL-1 and insulin resistance in obesity: a possible pathway for macrovascular disease Hum. Cell (IF 4.3) Pub Date : 2024-01-24 Mohnad Abdalla, Amr Ahmed El-Arabey, Zhongtao Gai
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Establishment and characterization of DPC-X4: a novel mixed-type ampullary cancer cell line Hum. Cell (IF 4.3) Pub Date : 2024-01-22
Abstract Mixed-type ampullary cancer is a distinct subtype of ampullary cancer that manifests a merging of the biological characteristics of both intestinal and pancreaticobiliary subtypes. The absence of established cell lines specific to this subtype has resulted in a concomitant scarcity of research on its tumorigenic mechanisms and the development of novel therapeutic modalities. The present study
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The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl4-caused murine liver fibrosis in vivo Hum. Cell (IF 4.3) Pub Date : 2024-01-14 Bingjie Liu, Xia Xie, Xin Yang, Chengyun Dou, Haibo Tang, Jing Liu
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A new lymphedema treatment using pyro-drive jet injection Hum. Cell (IF 4.3) Pub Date : 2024-01-14 Megumi Nishiyama, Yuko Sakaguchi, Sayuri Morito, Kei Nagase, Takehisa Sakumoto, Kunihiko Yamashita, Mariko Hashiguchi, Makoto Fukuda, Shuji Toda, Shigehisa Aoki
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Characterization of residual cancer by comparison of a pair of organoids established from a patient with esophageal squamous cell carcinoma before and after neoadjuvant chemotherapy Hum. Cell (IF 4.3) Pub Date : 2024-01-06 Takafumi Fuchino, Shusaku Kurogi, Yoshiyuki Tsukamoto, Tomotaka Shibata, Shoichi Fumoto, Hajime Fujishima, Keisuke Kinoshita, Yuka Hirashita, Masahide Fukuda, Chisato Nakada, Yusuke Itai, Kosuke Suzuki, Tomohisa Uchida, Hidefumi Shiroshita, Takashi Matsumoto, Yoshio Yamaoka, Koshiro Tsutsumi, Kensuke Fukuda, Ryo Ogawa, Kazuhiro Mizukami, Masaaki Kodama, Masafumi Inomata, Kazunari Murakami, Masatsugu
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Long noncoding RNA small nucleolar RNA host gene 5 facilitates neuropathic pain in spinal nerve injury by promoting SCN9A expression via CDK9 Hum. Cell (IF 4.3) Pub Date : 2024-01-02 Changsheng Wang, Rongsheng Chen, Xitian Zhu, Xiaobo Zhang, Nancheng Lian
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Passaging of gingival fibroblasts from periodontally healthy and diseased sites upregulates osteogenesis-related genes Hum. Cell (IF 4.3) Pub Date : 2024-01-01 Gerasimos D. Karlis, Ton Schoenmaker, Nektarios Tsoromokos, Olaf E. Veth, Bruno G. Loos, Teun J. de Vries
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Research hotspots and emerging trends in mesenchymal stem/stromal cells in bronchopulmonary dysplasia Hum. Cell (IF 4.3) Pub Date : 2023-12-30 Meng Ao, Heqian Ma, Meizhen Guo, Xuelin Dai, Xiaoying Zhang
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Establishment and characterization of NCC-PMP2-C1: a novel patient-derived cell line of pseudomyxoma peritonei with signet ring cells Hum. Cell (IF 4.3) Pub Date : 2023-12-25 Rei Noguchi, Yuki Yoshimatsu, Yooksil Sin, Takuya Ono, Ryuto Tsuchiya, Hiroshi Yoshida, Tohru Kiyono, Yutaka Yonemura, Tadashi Kondo
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Hypothermic machine perfusion reduces donation after circulatory death liver ischemia–reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway Hum. Cell (IF 4.3) Pub Date : 2023-12-22 Sheng Peng, Wenjin Liang, Zhongzhong Liu, Shaojun Ye, Zhiyong Peng, Zibiao Zhong, Qifa Ye
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Generation of iPSC lines (KAIMRCi003A, KAIMRCi003B) from a Saudi patient with Dravet syndrome carrying homozygous mutation in the CPLX1 gene and heterozygous mutation in SCN9A Hum. Cell (IF 4.3) Pub Date : 2023-12-19 Maryam Alowaysi, Mohammad Al-Shehri, Amani Badkok, Hanouf Attas, Doaa Aboalola, Moayad Baadhaim, Hajar Alzahrani, Mustafa Daghestani, Asima Zia, Khalid Al-Ghamdi, Asayil Al-Ghamdi, Samer Zakri, Sihem Aouabdi, Jesper Tegner, Khaled Alsayegh
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Tissue-specific populations from amniotic fluid-derived mesenchymal stem cells manifest variant in vitro and in vivo properties Hum. Cell (IF 4.3) Pub Date : 2023-12-12 Nengqing Liu, Yi Cheng, Ding Wang, Hongmei Guan, Diyu Chen, Juan Zeng, Dian Lu, Yuanshuai Li, Yinghong Yang, Qian Luo, Lifen Zhu, Bin Jiang, Xiaofang Sun, Bing Song
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Investigation of the mixed origins of the MGC-803 cell line reveals that it is a hybrid cell line derived from HeLa Hum. Cell (IF 4.3) Pub Date : 2023-12-11 Meimei Yang, Jing He, Sixuan Xia, Yudong Wang, Jun Xiong, Cong Liao, Nan Li, Sanfu Qu, Chao Shen
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Establishment and characterization of a patient-derived solitary fibrous tumor/hemangiopericytoma cell line model Hum. Cell (IF 4.3) Pub Date : 2023-12-09 Jing Yi Lee, Peiyong Guan, Abner Herbert Lim, Zexi Guo, Zhimei Li, Jessica Sook Ting Kok, Elizabeth Chun Yong Lee, Boon Yee Lim, Bavani Kannan, Jui Wan Loh, Cedric Chuan-Young Ng, Kah Suan Lim, Bin Tean Teh, Tun Kiat Ko, Jason Yongsheng Chan
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Delivery of microRNA-423-5p by exosome from adipose-derived stem/stromal cells inhibits DVL3 to potentiate autologous fat graft survival through adipogenesis and inflammatory response Hum. Cell (IF 4.3) Pub Date : 2023-12-02 Jinglin Zhu, Fangning Zhao, Yimeng Chai, Xinyu Jia, Facheng Li
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Treatment of type 2 diabetes mellitus with stem cells and antidiabetic drugs: a dualistic and future-focused approach Hum. Cell (IF 4.3) Pub Date : 2023-12-01 Priyamvada Amol Arte, Kanchanlata Tungare, Mustansir Bhori, Renitta Jobby, Jyotirmoi Aich
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Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression Hum. Cell (IF 4.3) Pub Date : 2023-11-23 Jinfeng Zhang, Yanzhong Xin, Xiaodong Ling, Hao Liang, Luquan Zhang, Chengyuan Fang, Jianqun Ma
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Estrogen receptor- and progesterone receptor-positive breast tumors have higher mRNA levels of NR3C1 and ZBTB16, with implications in prognosis for luminal A subtype Hum. Cell (IF 4.3) Pub Date : 2023-11-24 Caglar Berkel
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LINC00941: a novel player involved in the progression of human cancers Hum. Cell (IF 4.3) Pub Date : 2023-11-23 Qibin Yan, Xinming Su, Yunzhu Chen, Zehua Wang, Wenbo Han, Qing Xia, Yunan Mao, Jiahua Si, Hanbing Li, Shiwei Duan
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Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke Hum. Cell (IF 4.3) Pub Date : 2023-11-21 Maryam Adenike Salaudeen, Stuart Allan, Emmanuel Pinteaux
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Cell replacement therapy with stem cells in multiple sclerosis, a systematic review Hum. Cell (IF 4.3) Pub Date : 2023-11-21 Maria Veatriki Christodoulou, Ermioni Petkou, Natalia Atzemoglou, Eleni Gkorla, Aikaterini Karamitrou, Yannis V. Simos, Stefanos Bellos, Chryssa Bekiari, Panos Kouklis, Spyridon Konitsiotis, Patra Vezyraki, Dimitrios Peschos, Konstantinos I. Tsamis
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Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue Hum. Cell (IF 4.3) Pub Date : 2023-11-15 Zhendong Zhong, Kang Li, Chongyang Shen, Yuxiao Ma, Lu Guo
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Establishment and characterization of a novel hilar cholangiocarcinoma cell line, CBC3T-1 Hum. Cell (IF 4.3) Pub Date : 2023-11-15 Mingzhen Bai, Ningzu Jiang, Wenkang Fu, Chongfei Huang, Liang Tian, Ningning Mi, Long Gao, Haidong Ma, Yawen Lu, Jie Cao, Chao Zhang, Ping Yue, Yong Zhang, Yanyan Lin, Wenbo Meng, Xun Li
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Human dental pulp stem cells have comparable abilities to umbilical cord mesenchymal stem/stromal cells in regulating inflammation and ameliorating hepatic fibrosis Hum. Cell (IF 4.3) Pub Date : 2023-11-15 Peixing Chen, Yanchun Lin, Wenbo Lin, Yun Li, Ting Fu, Yuanyue Liu, Tian Guan, Man Xin, Ling Ye, Peiluan Wang, Haoyu Zeng, Kaitao Yao
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Establishment and functional testing of a novel ex vivo extraskeletal osteosarcoma cell model (USZ20-ESOS1) Hum. Cell (IF 4.3) Pub Date : 2023-11-11 Kim Harnisch, Sabrina Steiner, Alicia Pliego-Mendieta, Yanjiang Chen, Lara Planas-Paz, Chantal Pauli
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Establishment and characterization of a recurrent malignant peripheral nerve sheath tumor cell line: RsNF Hum. Cell (IF 4.3) Pub Date : 2023-11-08 Xingnan Zhang, Chenhao Hu, Dezhi Li, Song Liu
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Autophagy induced by Helicobacter Pylori infection can lead to gastric cancer dormancy, metastasis, and recurrence: new insights Hum. Cell (IF 4.3) Pub Date : 2023-11-04 Abdullatif Akbari, Seyed Mostafa Noorbakhsh Varnosfaderani, Melika Sadat Haeri, Zeinab Fathi, Fatemeh Aziziyan, Ali Yousefi Rad, Hamidreza Zalpoor, Mohsen Nabi-Afjadi, Yalda Malekzadegan
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Receptor tyrosine kinase gene expression profiling of orbital rhabdomyosarcoma unveils MET as a potential biomarker and therapeutic target Hum. Cell (IF 4.3) Pub Date : 2023-11-02 Sheetal Chauhan, Seema Sen, Khushboo Irshad, Seema Kashyap, Neelam Pushker, Rachna Meel, Mehar Chand Sharma
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Establishment and characterization of NCC-LMS3-C1: a novel patient-derived cell line of leiomyosarcoma Hum. Cell (IF 4.3) Pub Date : 2023-10-31 Yuki Yoshimatsu, Rei Noguchi, Julia Osaki, Yooksil Sin, Ryuto Tsuchiya, Takuya Ono, Taro Akiyama, Yuki Adachi, Yoshikazu Tanzawa, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
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Tracking circulating PD-L1-positive cells to monitor the outcome of patients with gastric cancer receiving anti-HER2 plus anti-PD-1 therapy Hum. Cell (IF 4.3) Pub Date : 2023-10-27 Xiaoyi Chong, Yanyan Li, Jialin Lu, Xujiao Feng, Yilin Li, Xiaotian Zhang
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Prospects of plant-derived exosome-like nanocarriers in oncology and tissue engineering Hum. Cell (IF 4.3) Pub Date : 2023-10-25 Shima Rahmati, Hafez Karimi, Morteza Alizadeh, Amir Hossein Khazaei, Ana Cláudia Paiva-Santos, Leila Rezakhani, Esmaeel Sharifi
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Targeting circulating tumor cells to prevent metastases Hum. Cell (IF 4.3) Pub Date : 2023-10-24 Karol Gostomczyk, Mohammed Dheyaa Marsool Marsool, Hamnah Tayyab, Anju Pandey, Jędrzej Borowczak, Facundo Macome, Jose Chacon, Tirth Dave, Mateusz Maniewski, Łukasz Szylberg
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Therapeutic potential of miRNAs in placental extracellular vesicles in ovarian and endometrial cancer Hum. Cell (IF 4.3) Pub Date : 2023-10-06 Yi Zhang, Yunhui Tang, Xinyue Chen, Xinyi Sun, Min Zhao, Qi Chen
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Activation of cell adhesion and migration is an early event of platelet-rich plasma (PRP)-dependent stimulation of human adipose-derived stem/stromal cells Hum. Cell (IF 4.3) Pub Date : 2023-10-03 Michika Fukui, Fangyuan Lai, Masakatsu Hihara, Toshihito Mitsui, Yuki Matsuoka, Zhongxin Sun, Sakurako Kunieda, Shigeru Taketani, Tokifumi Odaka, Kazu Okuma, Natsuko Kakudo
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MicroRNA-10a-5p-mediated downregulation of GATA6 inhibits tumor progression in ovarian cancer Hum. Cell (IF 4.3) Pub Date : 2023-09-28 Feiying Gao, Qiang Wu, Dan Lu
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Isolation of tumor stem-like cells from primary laryngeal squamous cell carcinoma cells (FD-LS-6) Hum. Cell (IF 4.3) Pub Date : 2023-09-27 Duo Zhang, Di Tang, Pen-tao Liu, Lei Tao, Li-ming Lu
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Copper in Cancer: from transition metal to potential target Hum. Cell (IF 4.3) Pub Date : 2023-09-26 Can Fang, Zhiwei Peng, Yaru Sang, Zihao Ren, Huiming Ding, Haibo Yuan, Kongwang Hu
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The effect of SARS-CoV-2 on the development of Parkinson's disease: the role of α-synuclein Hum. Cell (IF 4.3) Pub Date : 2023-09-21 Farideh Iravanpour, Majid Reza Farrokhi, Morteza Jafarinia, Razieh Tavakoli Oliaee
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A short-term three dimensional culture-based drug sensitivity test is feasible for malignant bone tumors Hum. Cell (IF 4.3) Pub Date : 2023-09-14 Hiroaki Goto, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Jun-ichi Nagai, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Yohei Miyagi
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Specific downregulation of microRNA-186 induces neural stem cell self-renewal by upregulating Bmi-1/FoxG1 expression Hum. Cell (IF 4.3) Pub Date : 2023-09-12 Tuantuan Chen, Jing Liu, Yang Liu, Yang Chen, Xue Wang