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Prelims Pathobiology (IF 1.985) Pub Date : 2021-01-20 Thomas Menter; Alexandar Tzankov
Pathobiology 2021;88:7–10
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Author Index Pathobiology (IF 1.985) Pub Date : 2021-01-20 Thomas Menter; Alexandar Tzankov
Pathobiology 2021;88:108
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Subject Index Pathobiology (IF 1.985) Pub Date : 2021-01-20 Thomas Menter; Alexandar Tzankov
Pathobiology 2021;88:109
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CXC Chemokine Receptor Type 5 Gene Polymorphisms in a Cohort of Egyptian Patients with Diffuse Large B-Cell Lymphoma Pathobiology (IF 1.985) Pub Date : 2020-12-30 Manal Mohamed Makhlouf; Eman Roshdy Radwan; Ola Mohamed Khorshed; Lamees Mohamed Fathi; Manal Mohamed Elmasry
Background: The chemokine receptor CXCR5 is selectively expressed on B cells; it is involved in lymphocyte homing and the development of normal lymphoid tissue. Its principle ligand is CXCL13 or B lymphocyte chemoattractant. Three polymorphisms in the CXCR5 gene, rs148351692 C/G, rs6421571 C/T, and rs78440425 G/A, have been identified. Objective: To assess the genetic polymorphisms of CXCR5 and evaluate
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Microbiome: A Supportive or a Leading Actor in Lung Cancer? Pathobiology (IF 1.985) Pub Date : 2020-12-22 Diana Martins; Fernando Mendes; Fernando Schmitt
Lung cancer is still the leading cause of cancer death worldwide. Despite the major diagnostic and therapeutic innovations, the effect on mortality has been modest and the overall survival is still poor. Better understanding of the pathology of these tumors is necessary in order to develop personalized therapeutic strategies in lung cancer patients. Human microbiome has been associated with normal
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Goodbye and Thank You Pathobiology (IF 1.985) Pub Date : 2020-12-18 Thomas Menter; Alexandar Tzankov
Pathobiology
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Publisher's Note Pathobiology (IF 1.985) Pub Date : 2020-12-18 Thomas Menter; Alexandar Tzankov
Pathobiology
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Investigations of Pathologists as a Key to Understanding Coronavirus Disease 2019 Pathobiology (IF 1.985) Pub Date : 2020-12-18 Thomas Menter; Alexandar Tzankov
Pathobiology
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New Editor-in-Chief of Pathobiology, the Journal of Translational Pathology Pathobiology (IF 1.985) Pub Date : 2020-12-17 Fernando Schmitt
Pathobiology
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Acknowledgement to Reviewers Pathobiology (IF 1.985) Pub Date : 2020-12-15
Pathobiology 2020;87:375–376
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Tumor-Infiltrating T Cells Concurrently Overexpress CD200R with Immune Checkpoints PD-1, CTLA-4, and TIM-3 in Non-Small-Cell Lung Cancer Pathobiology (IF 1.985) Pub Date : 2020-12-15 Yinghan Su; Shota Yamazaki; Ryo Morisue; Jun Suzuki; Toshiaki Yoshikawa; Tetsuya Nakatsura; Masahiro Tsuboi; Atsushi Ochiai; Genichiro Ishii
Introduction: CD200R has been reported to be the receptor for the immune checkpoint molecule CD200 and can transduce immune-suppressive signals. In this study, we mainly focused on the expression level of CD200R in T cells in pulmonary artery (PA) blood and non-small-cell lung cancer (NSCLC) tumor tissue. Methods: Immune cells were isolated from dissected tumor samples and PA blood of NSCLC patients
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Biosafety Requirements for Autopsies of Patients with COVID-19: Example of a BSL-3 Autopsy Facility Designed for Highly Pathogenic Agents Pathobiology (IF 1.985) Pub Date : 2020-12-09 Martina Loibner; Christine Langner; Peter Regitnig; Gregor Gorkiewicz; Kurt Zatloukal
Information obtained from autopsies of patients infected with high-risk pathogens is an important pillar in managing a proper response to pandemics, particular in the early phase. This is due to the fact that autopsy allows efficient evaluation of comorbidities for risk assessment, as well as identification of key pathophysiological and molecular mechanisms in organs driving the severity of disease
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The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis Pathobiology (IF 1.985) Pub Date : 2020-12-08 José Guilherme Datorre; Ana Carolina de Carvalho; Denise Peixoto Guimarães; Rui Manuel Reis
Colorectal cancer (CRC) is one of the most frequent and deadly neoplasms worldwide. Genetic factors, lifestyle habits, and inflammation are important risk factors associated with CRC development. In recent years, growing evidence has supporting the significant role of the intestinal microbiome in CRC carcinogenesis. Disturbances in the healthy microbial balance, known as dysbiosis, are frequently observed
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The Upper Digestive Tract Microbiome and Oesophageal Squamous Cell Carcinoma: Epidemiology, Pathogenesis, and Clinical Implications in Africa Pathobiology (IF 1.985) Pub Date : 2020-12-08 Jotamo Come; Joana Barbosa Pereira; Ricardo Pinto; Carla Carrilho; Luisa Pereira; Lúcio Lara Santos
The study of the microbiome has significantly contributed to our understanding of complex diseases including cancer, with a profound influence of the microbiota on clinical prognosis and the efficacy of cancer treatments. Oesophageal cancer is positioned amongst the most aggressive malignant diseases, resulting from a complex interaction between anthropometric, genetic, immune response, and environmental
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COVID-19 Autopsies: A Case Series from Poland Pathobiology (IF 1.985) Pub Date : 2020-11-30 Ewa Chmielik; Joanna Jazowiecka-Rakus; Grzegorz Dyduch; Anna Nasierowska-Guttmejer; Lukasz Michalowski; Aleksander Sochanik; Magdalena Ulatowska-Bialas
This paper presents autopsy findings of 3 COVID-19 patients randomly selected for post-mortem from two tertiary referral Polish hospitals. Analysis of macroscopic, histopathological findings with clinical features was performed. All 3 deceased patients were Caucasian males (average age 61 years, range from 56 to 68 years). Using real-time polymerase chain reaction assay, the patients were confirmed
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miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/β-Catenin Signaling Pathway in Gastric Cancer Pathobiology (IF 1.985) Pub Date : 2020-11-30 Weidong Zhou; Xiaoyun Ding; Peihua Jin; Peifei Li
Gastric cancer (GC) is a highly prevalent digestive malignant tumor, ranking second in the tumor-related mortality globally. The microRNAs have been confirmed to be connected with GC progression. Accumulative evidence has suggested that miR-6838-5p exerts a suppressive effect on human cancers. Nonetheless, whether miR-6838-5p is involved in the regulation of GC remains to be investigated. During our
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LncRNA MAFG-AS1 Promotes the Progression of Bladder Cancer by Targeting the miR-143-3p/COX-2 Axis Pathobiology (IF 1.985) Pub Date : 2020-11-25 Dengbao Li; Siwen Zhong; Zhiqiang Zhu; Xinan Jiang; Junhao Zhang; Jiang Gu; Fangmin Chen
Background: Long noncoding RNAs (lncRNAs) are potential biomarkers that are very important for the development of cancer. Studies show that lncRNAs are significantly correlated with the carcinogenesis and progression of bladder cancer (BLCA). In this research, we aimed at probing into the role of lncRNA MAFG-AS1 in the tumorigenesis of BLCA. Methods: RT-qPCR was employed to detect MAFG-AS1 expression
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Microbiome and Cervical Cancer Pathobiology (IF 1.985) Pub Date : 2020-11-23 Cristina Paula Castanheira; Mayara Luciana Sallas; Rafaella Almeida Lima Nunes; Noely Paula Cristina Lorenzi; Lara Termini
Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for the development of cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in cervical disease onset and progression either by favoring or by preventing HPV infection and persistence. The microbiome of a healthy female genital tract is characterized by the
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Regulatory Single Nucleotide Polymorphism Increases TERT Promoter Activity in Thyroid Carcinoma Cells Pathobiology (IF 1.985) Pub Date : 2020-11-23 Tatsuya Hirokawa; Yuu Arimasu; Tomohiro Chiba; Yoko Nakazato; Masachika Fujiwara; Hiroshi Kamma
Background/Aim: The telomerase reverse transcriptase (TERT) promoter has a regulatory single nucleotide polymorphism (rSNP), rs2853669, and occasionally shows point mutations C228T and C250T. Although C228T and C250T have been well examined to increase TERT promoter activity and are known as risk factors for thyroid carcinoma, the significance of rs2853669 has not been well investigated. This study
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Oral Microbiota and Cancer Development Pathobiology (IF 1.985) Pub Date : 2020-11-11 Heidi Tuominen; Jaana Rautava
Oral microbiota are among the most diverse in the human body. More than 700 species have been identified in the mouth, and new sequencing methods are allowing us to discover even more species. The anatomy of the oral cavity is different from that of other body sites. The oral cavity has mucosal surfaces (the tongue, the buccal mucosa, the gingiva, and the palate), hard tissues (the teeth), and exocrine
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Gastric Cancer in BRCA1 Germline Mutation Carriers: Results of Endoscopic Screening and Molecular Analysis of Tumor Tissues Pathobiology (IF 1.985) Pub Date : 2020-11-06 Albina A. Avanesyan; Anna P. Sokolenko; Alexandr O. Ivantsov; Maxim A. Kleshchev; Mikhail A. Maydin; Ilya V. Bizin; Grigory A. Raskin; Ksenia V. Shelekhova; Tatiana V. Gorodnova; Alexandr A. Bessonov; Elena I. Anisimova; Olga A. Volynshchikova; Alexandr A. Romanko; Valeria I. Ni; Robert V. Broyde; Oleg B. Tkachenko; Aldon J. Whitehead; Alexandr M. Scherbakov; Evgeny N. Imyanitov
Introduction: There is some evidence suggesting a link between BRCA1/2 germline mutations and increased risk of gastric cancer. Methods: Endoscopic screening for stomach malignancies was performed in 120 BRCA1 mutation carriers in order to evaluate the probability of detecting the tumor disease. Results: No instances of gastric cancer were revealed at the first visit. The analysis of atrophic changes
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Retrospective Post-mortem SARS-CoV-2 RT-PCR of Autopsies with COVID-19-Suggestive Pathology Supports the Absence of Lethal Community Spread in Basel, Switzerland, before February 2020 Pathobiology (IF 1.985) Pub Date : 2020-11-06 Jasmin Dionne Haslbauer; Valeria Perrina; Matthias Matter; Athanassios Dellas; Michael J. Mihatsch; Alexandar Tzankov
Introduction: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread around the world. While the first case was recorded in Hubei in December 2019, the extent of early community spread in Central Europe before this period is unknown. A high proportion of asymptomatic cases and undocumented infections, high transmissibility, and
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A Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis Pathobiology (IF 1.985) Pub Date : 2020-11-02 Christopher R. Showers; Gerard J. Nuovo; Amit Lakhanpal; Caroline H. Siegel; Juliet Aizer; Lauren Elreda; Alexandra Halevi; Andrew R. Lai; Doruk Erkan; Cynthia M. Magro
We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined
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In situ Evidence of Collagen V and Interleukin-6/Interleukin-17 Activation in Vascular Remodeling of Experimental Pulmonary Hypertension Pathobiology (IF 1.985) Pub Date : 2020-10-23 Sabrina Setembre Batah; Maiara Almeida Alda; Rebeca Rodrigues Lopes Roslindo Figueira; Heloisa R. Cruvinel; Luis Perdoná Rodrigues da Silva; Juliana Machado-Rugolo; Ana Paula Velosa; Walcy Rosolia Teodoro; Marcelo Balancin; Pedro Leme Silva; Vera Luiza Capelozzi; Alexandre Todorovic Fabro
Several studies have reported the pathophysiologic and molecular mechanisms responsible for pulmonary arterial hypertension (PAH). However, the in situ evidence of collagen V (Col V) and interleukin-17 (IL-17)/interleukin-6 (IL-6) activation in PAH has not been fully elucidated. We analyzed the effects of collagen I (Col I), Col V, IL-6, and IL-17 on vascular remodeling and hemodynamics and its possible
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The Liver in COVID-19-Related Death: Protagonist or Innocent Bystander? Pathobiology (IF 1.985) Pub Date : 2020-10-27 Grégory Schmit; Julie Lelotte; Jessica Vanhaebost; Yves Horsmans; Mieke Van Bockstal; Pamela Baldin
Introduction: The coronavirus disease 2019 (COVID-19) infection, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), involves several organs through participation of angiotensin-conversion enzyme 2 (ACE2) receptors. The presence of ACE2 receptors in the liver renders this organ a potential target for the novel coronavirus. Methods: We performed 14 complete autopsies of patients
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The Impact of COVID-19 Disease on Platelets and Coagulation Pathobiology (IF 1.985) Pub Date : 2020-10-13 Geoffrey D. Wool; Jonathan L. Miller
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and frequent venous
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Application of "Tissueoid Cell Culture System" Using a Silicate Fiber Scaffold for Cancer Research. Pathobiology (IF 1.985) Pub Date : 2020-09-23 Shoko Murakami,Ken-Ichi Mukaisho,Takuya Iwasa,Masaaki Kawabe,Saori Yoshida,Naoko Taniura,Takahisa Nakayama,Masaharu Noi,Gaku Yamamoto,Hiroyuki Sugihara
Background: We developed a 3-dimensional (3D) culture system using a high-purity silica fiber scaffold of unwoven sheets called CellbedTM. Methods: We used adherent colon and esophagogastric junction adenocarcinoma cells, tongue squamous cell carcinoma (SqCC) cells, and nonadherent gastric cancer cells. These cells were subjected to staining with various substances and observed by electron microscopy
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Placental Pathology Findings during and after SARS-CoV-2 Infection: Features of Villitis and Malperfusion. Pathobiology (IF 1.985) Pub Date : 2020-09-18 Thomas Menter,Kirsten Diana Mertz,Sizun Jiang,Han Chen,Cécile Monod,Alexandar Tzankov,Salome Waldvogel,Sven M Schulzke,Irene Hösli,Elisabeth Bruder
Since the outbreak of coronavirus disease 2019 (COVID-19), there has been a debate whether pregnant women are at a specific risk for COVID-19 and whether it might be vertically transmittable through the placenta. We present a series of five placentas of SARS coronavirus 2 (SARS-CoV-2)-positive women who had been diagnosed with mild symptoms of COVID-19 or had been asymptomatic before birth. We provide
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Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience. Pathobiology (IF 1.985) Pub Date : 2020-09-17 Sarah S Elsoukkary,Maria Mostyka,Alicia Dillard,Diana R Berman,Lucy X Ma,Amy Chadburn,Rhonda K Yantiss,Jose Jessurun,Surya V Seshan,Alain C Borczuk,Steven P Salvatore
Background: A novel coronavirus, SARS-CoV-2, was identified in Wuhan, China in late 2019. This virus rapidly spread around the world causing disease ranging from minimal symptoms to severe pneumonia, which was termed coronavirus disease (i.e., COVID). Postmortem examination is a valuable tool for studying the pathobiology of this new infection. Methods: We report the clinicopathologic findings from
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Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers. Pathobiology (IF 1.985) Pub Date : 2020-09-16 Yoshifumi Takei,Toshifumi Hara,Akiko Suzuki,Keichiro Mihara,Kazuyoshi Yanagihara
Objectives: Scirrhous gastric cancer, which accounts for approximately 10% of all gastric cancers, often disseminates to the peritoneum, leading to intractable cases with poor prognosis. There is an urgent need for new treatment approaches for this difficult cancer. Methods: We previously established an original cell line, HSC-60, from a scirrhous gastric cancer patient and isolated a peritoneal-metastatic
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High Activation of the AKT Pathway in Human Multicystic Renal Dysplasia. Pathobiology (IF 1.985) Pub Date : 2020-09-14 Alexia Apostolou,Brice Poreau,Loris Delrieu,Julien Thévenon,Pierre-Simon Jouk,Guillaume Lallemand,Anouk Emadali,Herve Sartelet
Multicystic renal dysplasia is a congenital cystic anomaly of the kidney caused by abnormal metanephric differentiation with immature tubules. It is surrounded by mesenchymal collars and islands of immature mesenchyma present between the cysts. The PI3K-AKT-mTOR signaling pathway is a key regulator involved in cell growth, proliferation, motility, survival, and apoptosis. Activation of the PI3K-AKT-mTOR
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Radiation-Associated Primary Osteosarcoma of the Breast. Pathobiology (IF 1.985) Pub Date : 2020-09-11 Helen Bartlett,Maiar Elghobashy,Nayneeta Deshmukh,Rashmi Rao,Abeer M Shaaban
Introduction: Non-epithelial primary mammary osteosarcomas are extremely rare. The differentials include metaplastic carcinoma and malignant phyllodes tumour. This is the first published case of primary breast osteosarcoma arising after local radiotherapy. Case Presentation: A 73-year-old female presented with a right-sided breast lump. The same breast had been irradiated 11 years previously for invasive
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Calcium Influx Kinetics and the Characteristics of Potassium Channels in Peripheral T Lymphocytes in Systemic Sclerosis. Pathobiology (IF 1.985) Pub Date : 2020-09-10 Gergely Toldi,Nóra Legány,Imre Ocsovszki,Attila Balog
Background: Systemic sclerosis (SSc) is a chronic, immune-mediated, connective tissue disease causing microvascular abnormalities and fibrosis. The cytoplasmic calcium influx kinetics in T lymphocytes governs lymphocyte activation in this inflammatory process. The inhibition of Kv1.3 and IKCa1 potassium channels reduces calcium influx. Methods: This study aimed to analyze cytoplasmic calcium influx
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Editorial. Pathobiology (IF 1.985) Pub Date : 2020-08-31 Bettina Borisch,Laetitia Bourquin
Pathobiology
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Unusual Presentation of Mammary Calciphylaxis in a Patient on Long-Standing Renal Dialysis. Pathobiology (IF 1.985) Pub Date : 2020-08-19 Maiar Elghobashy,Shams Vaquas,Mona Elshafie,Shekhar Kaneri,Abeer M Shaaban
Introduction: Calciphylaxis is a condition which involves ectopic deposition of calcium in arterioles of various organ systems. Here, we present a rare case of mammographic calcifications in a patient on long-standing renal dialysis. Case: This is a 57-year-old female who presented to breast clinic with unilateral severe pain and lumpiness of her breast. On mammography, calcifications were identified
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Hydrophobicity and the Physico-Chemical Basis of Immunotolerance. Pathobiology (IF 1.985) Pub Date : 2020-07-29 Darja Kanduc
This study analyzes the primary electrostatic interaction between the membrane-bound B-cell receptor and antigen peptide determinants, and identifies peptide frequency and hydrophobicity as the main factors that govern and shape immunotolerance versus immunoreactivity. Pathobiology
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The Two Sides of Cytopathology during the COVID-19 Health Emergency: Screening versus Diagnosis. Pathobiology (IF 1.985) Pub Date : 2020-07-21 Pasquale Pisapia,Giancarlo Troncone
Pathobiology
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Molecular Complexity of Lymphovascular Invasion: The Role of Cell Migration in Breast Cancer as a Prototype. Pathobiology (IF 1.985) Pub Date : 2020-07-09 Yousif A Kariri,Mohammed A Aleskandarany,Chitra Joseph,Sasagu Kurozumi,Omar J Mohammed,Michael S Toss,Andrew R Green,Emad A Rakha
Lymphovascular invasion (LVI) is associated with poor outcome in breast cancer (BC); however, its underlying mechanisms remain ill-defined. LVI in BC develops through complex molecular pathways involving not only the interplay with the surrounding microenvironment along with endothelial cells lining the lymphovascular spaces but also changes in the malignant epithelial cells with the acquisition of
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The Impact of the COVID-19 Pandemic and the Associated Belgian Governmental Measures on Cancer Screening, Surgical Pathology and Cytopathology. Pathobiology (IF 1.985) Pub Date : 2020-07-07 Marie-Caroline de Pelsemaeker,Yves Guiot,Jonathan Vanderveken,Christine Galant,Mieke Rosalie Van Bockstal
Introduction: The severe acute respiratory syndrome coronavirus 2 caused a pandemic of coronavirus disease 2019 (COVID-19). Unprecedented public health actions were introduced, including social distancing, travel restrictions and quarantine. The Belgian government announced a national emergency plan, thereby postponing all non-urgent medical consultations and operations. This report analyses the impact
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NudCD1 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer Cells through the Activation of IGF1R-ERK1/2. Pathobiology (IF 1.985) Pub Date : 2020-07-07 Bin He,Shihui Xia,Zengwang Zhang
Background: NudC domain containing 1 (NudCD1) is an oncoprotein related to diverse cancers. This study aims to investigate the expression, role, and regulatory mechanism of NudCD1 in non-small cell lung cancer (NSCLC). Methods: qRT-PCR, Western blot, and immunohistochemistry were performed to detect the expressions of NudCD1 in NSCLC tissues and cell lines. The correlation between NudCD1 expression
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SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma. Pathobiology (IF 1.985) Pub Date : 2020-06-19 Yuji Yamamoto,Naohide Oue,Ryuichi Asai,Narutaka Katsuya,Naohiro Uraoka,Naoya Sakamoto,Kazuhiro Sentani,Kazuaki Tanabe,Hideki Ohdan,Wataru Yasui
Objectives: Esophageal cancer is the sixth most common malignancy worldwide. Signal peptidase complex 18 (SPC18) protein, which is encoded by the SEC11A gene, is one of the subunits of the signal peptidase complex and plays an important role in the secretion of proteins including transforming growth factor α (TGF-α). In this study, we investigated the significance of SPC18 expression in human esophageal
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Immunomorphological Features of the Placenta in Allogeneic Pregnancy as the Background for the Development of Obstetric Complications. Pathobiology (IF 1.985) Pub Date : 2020-05-20 Ekaterina E Rudenko,Evgeniya A Kogan,Тatiana А Demura,Nickolay V Zharkov,Natalia S Trifonova,Elvira V Zhukova,Leonid S Aleksandrov,Sofia N Bayanova
Objective: To study the structural and immunohistochemical features of placentas in women after assisted reproductive technology (ART) with allogeneic eggs (oocyte donation and surrogate motherhood). Study Design: The study involved 89 women whose pregnancy occurred as a result of in vitro fertilization (IVF) with a donor egg in a surrogate motherhood program (IVF-SM, n = 47 patients) or oocyte donation
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title page / table of contents Pathobiology (IF 1.985) Pub Date : 2020-05-19 Ewa Chmielik
Pathobiology 2020;87:51–54
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Lack of Association between IFNL3 Polymorphism and Human Papillomavirus Infection and Their Progression in HIV-Infected Women Receiving Antiretroviral Treatment. Pathobiology (IF 1.985) Pub Date : 2020-05-19 Ahd Ouladlahsen,Rajaa Bensghir,Hanâ Baba,Asmaa Haddaji,Islam Abbadi,Imane Zaidane,Hanan Badi,Mustapha Sodqi,Latifa Marih,Lahcen Wakrim,Kamal Marhoum El Filali,Soumaya Benjelloun,Sayeh Ezzikouri
Background: It has been reported that interferon-λ3 (IFNL3)might influence the pathogenesis and clearance of human papillomavirus (HPV) infection. The impact of IFNL3 single-nucleotide polymorphism (SNP) on HPV infection is currently unknown. The aim of this study was to investigate the association between variants in the IFNL3 region and HPV infection in women with human immunodeficiency virus (HIV)
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Mutational Profiling of Driver Tumor Suppressor and Oncogenic Genes in Brazilian Malignant Pleural Mesotheliomas. Pathobiology (IF 1.985) Pub Date : 2020-05-05 Nathália C Campanella,Eduardo Caetano Silva,Gustavo Dix,Fabiana de Lima Vazquez,Flávia Escremim de Paula,Gustavo N Berardinelli,Marcelo Balancin,Roger Chammas,Rossana V Mendoza Lopez,Henrique César S Silveira,Vera Luiza Capelozzi,Rui Manuel Reis
Background: Malignant pleural mesothelioma (MPM) is a highly lethal disease comprising a heterogeneous group of tumors with challenging to predict biological behavior. The diagnosis is complex, and the histologic classification includes 2 major subtypes of MPM: epithelioid (∼60% of cases) and sarcomatous (∼20%). Its identification depends upon pathological investigation supported by clinical and radiological
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The Multifaceted Nature of Tumor Microenvironment in Breast Carcinomas. Pathobiology (IF 1.985) Pub Date : 2020-04-23 Laura Annaratone,Eliano Cascardi,Elena Vissio,Ivana Sarotto,Ewa Chmielik,Anna Sapino,Enrico Berrino,Caterina Marchiò
Heterogeneity in breast carcinomas can be appreciated at various levels, from morphology to molecular alterations, and there are well-known genotypic-phenotypic correlations. Clinical decision-making is strictly focused on the evaluation of tumor cells and is based on the assessment of hormone receptors and of the HER2 status, by means of a combination of immunohistochemical and in situ hybridization
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Impact of the Tumor Microenvironment on the Gene Expression Profile in Papillary Thyroid Cancer. Pathobiology (IF 1.985) Pub Date : 2020-04-22 Malgorzata Oczko-Wojciechowska,Aleksandra Pfeifer,Michal Jarzab,Michał Swierniak,Dagmara Rusinek,Tomasz Tyszkiewicz,Malgorzata Kowalska,Ewa Chmielik,Ewa Zembala-Nozynska,Agnieszka Czarniecka,Barbara Jarzab,Jolanta Krajewska
Transcriptome of papillary thyroid cancer (PTC) is well characterized and correlates with some prognostic and genotypic factors, but data addressing the interaction between PTC and tumor microenvironment (TME) are scarce. Therefore, in the present study, we aimed to assess the impact of TME on gene expression profile in PTC. We evaluated the gene expression profile in PTC and normal thyroid cells isolated
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Pathology and Tumor Microenvironment: Past, Present, and Future. Pathobiology (IF 1.985) Pub Date : 2020-04-14 Ewa Chmielik
Pathobiology 2020;87:55–57
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Heterogeneity Fair: Commentary to Menter and Tzankov "Lymphomas and Their Microenvironment: A Multifaceted Relationship". Pathobiology (IF 1.985) Pub Date : 2020-04-09 Claudio Tripodo
Pathobiology 2020;87:155–158
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Microenvironment-Derived FGF-2 Stimulates Renal Cell Carcinoma Cell Proliferation through Modulation of p27Kip1: Implications for Spatial Niche Formation and Functional Intratumoral Heterogeneity. Pathobiology (IF 1.985) Pub Date : 2020-03-31 Weibin Hou,Adam Kaczorowski,Philippa Lantwin,Maximilian Kippenberger,Viktoria Schütz,Desiree Franke,Svenja Christina Dieffenbacher,Markus Hohenfellner,Stefan Duensing
BACKGROUND/OBJECTIVE Clear cell renal cell carcinoma (ccRCC) is characterized by a high degree of functional intratumoral heterogeneity (ITH). This is highlighted by the finding that tumor cell proliferation and intracellular signaling occur preferentially in the tumor periphery. The driving forces for such a spatial organization are largely unknown. Herein, we investigate the role of the tumor microenvironment
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Activin A Expressed in Rheumatoid Synovial Cells Downregulates TNFα-Induced CXCL10 Expression and Osteoclastogenesis. Pathobiology (IF 1.985) Pub Date : 2020-03-03 Tatsuomi Kuranobu,Sho Mokuda,Katsuhiro Oi,Tadahiro Tokunaga,Kazutoshi Yukawa,Hiroki Kohno,Yusuke Yoshida,Shintaro Hirata,Eiji Sugiyama
OBJECTIVE Activin A is known to be highly expressed in rheumatoid synovium. In the present study, we investigated the effect of inflammatory cytokines on activin A production and its role in rheumatoid inflammation using freshly prepared rheumatoid synovial cells (fresh-RSC). METHODS Fresh-RSC from patients with rheumatoid arthritis were obtained and stimulated with multiple cytokines for activin A
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B7-H3 and B7-H4 Expression in Breast Cancer and Their Association with Clinicopathological Variables and T Cell Infiltration. Pathobiology (IF 1.985) Pub Date : 2020-02-21 Nah Ihm Kim,Min Ho Park,Sun-Seog Kweon,Ji Shin Lee
OBJECTIVES B7-H3 and B7-H4 proteins are expressed in breast cancer tissues, but their relationships with respect to tumor immune surveillance and outcomes in breast cancer are not conclusive. METHODS We first examined B7-H3 and B7-H4 mRNA expression in the Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Next, mRNA and protein expression were assessed by RNAscope in situ
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Molecular Profile of Gastrointestinal Stromal Tumors in Sixty-Eight Patients from a Single Swiss Institution. Pathobiology (IF 1.985) Pub Date : 2020-02-20 Simon Haefliger,Katharina Marston,Darius Juskevicius,Nathalie Meyer-Schaller,Anja Forster,Stefan Nicolet,Paul Komminoth,Edouard Stauffer,Gieri Cathomas,Sylvia Hoeller,Luigi Tornillo,Stefan Dirnhofer,Luigi M Terracciano,Michel Bihl,Matthias S Matter
INTRODUCTION Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. It has distinct molecular features and primarily affects the KIT and PDGFRA genes. OBJECTIVE We wanted to assess the molecular profile of 68 GIST patients who were sequenced consecutively between 2014 and 2019 at our institute of pathology. METHODS Our cohort comprised 60 primary
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Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer. Pathobiology (IF 1.985) Pub Date : 2020-02-11 Aleksandra Sejda,Dawid Sigorski,Jacek Gulczyński,Wojciech Wesołowski,Joanna Kitlińska,Ewa Iżycka-Świeszewska
The tumor microenvironment (TME) plays an essential role in the development and progression of neoplasms. TME consists of the extracellular matrix and numerous specialized cells interacting with cancer cells by paracrine and autocrine mechanisms. Tumor axonogenesis and neoneurogenesis constitute a developing area of investigation. Prostate cancer (PC) is one of the most common malignancies in men worldwide
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[Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma]. Pathobiology (IF 1.985) Pub Date : 2020-02-07 Miroslaw Snietura,Adam Brewczynski,Agnieszka Kopec,Tomasz Rutkowski
INTRODUCTION Human papillomavirus with a high oncogenic potential (HR-HPV) is responsible for more than a half of squamous cell carcinomas of the oropharynx. The HR-HPV-dependent cases of this tumour have a better prognosis compared to the HR-HPV-negative cases, despite the usually more advanced disease at the time of diagnosis. In addition to genetic and epigenetic factors, the causes of this more
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Development of a Novel One-Step Automated Rapid in situ Hybridization for Anaplastic Lymphoma Kinase Rearrangement Using Non-Contact Alternating-Current Electric-Field Mixing. Pathobiology (IF 1.985) Pub Date : 2020-02-05 Kazuhiro Imai,Shinogu Takashima,Satoshi Fujishima,Tsubasa Matsuo,Shin-Nosuke Watanabe,Hiroshi Nanjo,Yoichi Akagami,Ryuta Nakamura,Kaori Terata,Akiyuki Wakita,Yusuke Sato,Satoru Motoyama,Yoshihiro Minamiya
Echinoderm microtubule-associated protein-like 4 and anaplastic lymphoma kinase (ALK) fusion gene rearrangement is a key driver mutation in non-small cell lung cancer (NSCLC). Although Break-Apart ALK fluorescence in situ hybridization (FISH) is a reliable diagnostic method for detecting ALK gene rearrangement, it is also costly and time-consuming to use as a routine screening test. Our aim was to
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Pathology of the Fallopian Tube: Tubal Involvement by Ovarian Tumors and Incidental Findings in the Nontumoral Setting. Pathobiology (IF 1.985) Pub Date : 2020-01-23 Georgia Karpathiou,Celine Chauleur,Melany Venet,Alix Clemenson,Michel Peoc'h
The fallopian tube is thought to be the site of origin of most high-grade serous carcinomas (HGSCs). However, how often the tube is abnormal in the setting of other ovarian tumors is unknown. The aim of this study is to define the frequency of tubal abnormalities in the tumoral (n = 245) and nontumoral (n = 184) setting. We found that in ovarian tumors, 52.2% of the tubes were normal, while 39.2% were
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