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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2024-01-04
Abstract not available
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Telomere-specific regulation of TERRA and its impact on telomere stability Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-12-11 Julieta Rivosecchi, Katarina Jurikova, Emilio Cusanelli
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Editorial: Special issue SCDB “Cell death and survival”: Cell death and resilience in health and disease Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-12-02 Maddalena Nano, Denise J. Montell
Abstract not available
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-11-30
Abstract not available
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Apoptotic signaling: Beyond cell death Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-11-19 Maddalena Nano, Denise J. Montell
Apoptosis is the best described form of regulated cell death, and was, until relatively recently, considered irreversible once particular biochemical points-of-no-return were activated. In this manuscript, we examine the mechanisms cells use to escape from a self-amplifying death signaling module. We discuss the role of feedback, dynamics, propagation, and noise in apoptotic signaling. We conclude
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Persister cell plasticity in tumour drug resistance Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-11-16 Paul C. McDonald, Shoukat Dedhar
The emergence of therapeutic resistance remains a formidable barrier to durable responses by cancer patients and is a major cause of cancer-related deaths. It is increasingly recognized that non-genetic mechanisms of acquired resistance are important in many cancers. These mechanisms of resistance rely on inherent cellular plasticity where cancer cells can switch between multiple phenotypic states
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Immunogenic cell stress and death in the treatment of cancer Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-11-16 Hui Pan, Peng Liu, Liwei Zhao, Yuhong Pan, Misha Mao, Guido Kroemer, Oliver Kepp
The successful treatment of oncological malignancies which results in long-term disease control or the complete eradication of cancerous cells necessitates the onset of adaptive immune responses targeting tumor-specific antigens. Such desirable anticancer immunity can be triggered via the induction of immunogenic cell death (ICD) of cancer cells, thus converting malignant cells into an in situ vaccine
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Dynamic interplay between human alpha-satellite DNA structure and centromere functions Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-11-04 Elena Di Tommaso, Simona Giunta
Maintenance of genome stability relies on functional centromeres for correct chromosome segregation and faithful inheritance of the genetic information. The human centromere is the primary constriction within mitotic chromosomes made up of repetitive alpha-satellite DNA hierarchically organized in megabase-long arrays of near-identical higher order repeats (HORs). Centromeres are epigenetically specified
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-11-03
Abstract not available
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The mechanisms and roles of mitochondrial dynamics in C. elegans Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-10-31 Daniel Campbell, Steven Zuryn
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DNA strand breaks at centromeres: Friend or foe? Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-10-21 Emily Graham, Fumiko Esashi
Centromeres are large structural regions in the genomic DNA, which are essential for accurately transmitting a complete set of chromosomes to daughter cells during cell division. In humans, centromeres consist of highly repetitive α-satellite DNA sequences and unique epigenetic components, forming large proteinaceous structures required for chromosome segregation. Despite their biological importance
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-10-19
Abstract not available
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The implications of satellite DNA instability on cellular function and evolution Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-10-17 Jullien M. Flynn, Yukiko M. Yamashita
Abundant tandemly repeated satellite DNA is present in most eukaryotic genomes. Previous limitations including a pervasive view that it was uninteresting junk DNA, combined with challenges in studying it, are starting to dissolve - and recent studies have found important functions for satellite DNAs. The observed rapid evolution and implied instability of satellite DNA now has important significance
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Emerging roles of DNA repair factors in the stability of centromeres Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-10-16 Francesca Marcon, Simona Giunta, Margherita Bignami
Satellite DNA sequences are an integral part of centromeres, regions critical for faithful segregation of chromosomes during cell division. Because of their complex repetitive structure, satellite DNA may act as a barrier to DNA replication and other DNA based transactions ultimately resulting in chromosome breakage. Over the past two decades, several DNA repair proteins have been shown to bind and
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Proteotoxic stress and the ubiquitin proteasome system Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-19 Rachel Kandel, Jasmine Jung, Sonya Neal
The ubiquitin proteasome system maintains protein homeostasis by regulating the breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The efficient elimination is vital for preventing damage to the cell by misfolded proteins, known as proteotoxic stress. Proteotoxic stress can lead to the collapse of protein homeostasis and can alter the function of the ubiquitin proteasome
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Thrombospondin proteins – Versatile extracellular proteins with multiple biological functions Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-18 Kenneth W. Adolph
Abstract not available
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Editorial on “Vascular cell fate in health and disease” Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-18 Christine Cheung
Abstract not available
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The Calvin Benson Bassham cycle Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-14 Christine A. Raines, Amanda P. Cavanagh
Abstract not available
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Control of coronary vascular cell fate in development and regeneration Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-14 Ian R. McCracken, Nicola Smart
The coronary vasculature consists of a complex hierarchal network of arteries, veins, and capillaries which collectively function to perfuse the myocardium. However, the pathways controlling the temporally and spatially restricted mechanisms underlying the formation of this vascular network remain poorly understood. In recent years, the increasing use and refinement of transgenic mouse models has played
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New insights into the role of thrombospondin-1 in glioblastoma development Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-09 Andreas Bikfalvi, Joris Guyon, Thomas Daubon
Glioblastoma (GB), the most malignant subtype of diffuse glioma, is highly aggressive, invasive and vascularized. Its median survival is still short even with maximum standard care. There is a need to identify potential new molecules and mechanisms, that are involved in the interactions of GB cells with the tumor microenvironment (TME), for therapeutic intervention. Thrombospondin-1 (TSP1) is a multi-faceted
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Epigenetic regulation of inflammation Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-07 Aamir Ahmad
Abstract not available
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A journey through translational control Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-01 Huili Guo
Abstract not available
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Plasma membrane repair empowers the necrotic survivors as innate immune modulators Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-28 Shiqi Xu, Tyler J. Yang, Suhong Xu, Yi-Nan Gong
The plasma membrane is crucial to the survival of animal cells, and damage to it can be lethal, often resulting in necrosis. However, cells possess multiple mechanisms for repairing the membrane, which allows them to maintain their integrity to some extent, and sometimes even survive. Interestingly, cells that survive a near-necrosis experience can recognize sub-lethal membrane damage and use it as
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Selective induction of programmed cell death using synthetic biology tools Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-17 Kateryna Shkarina, Petr Broz
Regulated cell death (RCD) controls the removal of dispensable, infected or malignant cells, and is thus essential for development, homeostasis and immunity of multicellular organisms. Over the last years different forms of RCD have been described (among them apoptosis, necroptosis, pyroptosis and ferroptosis), and the cellular signaling pathways that control their induction and execution have been
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C. elegans as a model for health and disease Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-09 Steven Zuryn
Abstract not available
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Vagal sensory pathway for the gut-brain communication Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-08 Yiyun Cao, Rui Li, Ling Bai
The communication between the gut and brain is crucial for regulating various essential physiological functions, such as energy balance, fluid homeostasis, immune response, and emotion. The vagal sensory pathway plays an indispensable role in connecting the gut to the brain. Recently, our knowledge of the vagal gut-brain axis has significantly advanced through molecular genetic studies, revealing a
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The Calvin-Benson-Bassham cycle in C4 and Crassulacean acid metabolism species Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-04 Martha Ludwig, James Hartwell, Christine A. Raines, Andrew J. Simkin
The Calvin-Benson-Bassham (CBB) cycle is the ancestral CO2 assimilation pathway and is found in all photosynthetic organisms. Biochemical extensions to the CBB cycle have evolved that allow the resulting pathways to act as CO2 concentrating mechanisms, either spatially in the case of C4 photosynthesis or temporally in the case of Crassulacean acid metabolism (CAM). While the biochemical steps in the
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-03
Abstract not available
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Development and regeneration of the vagus nerve Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-01 Adam J. Isabella, Cecilia B. Moens
The vagus nerve, with its myriad constituent axon branches and innervation targets, has long been a model of anatomical complexity in the nervous system. The branched architecture of the vagus nerve is now appreciated to be highly organized around the topographic and/or molecular identities of the neurons that innervate each target tissue. However, we are only just beginning to understand the developmental
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Thrombospondin-1 in vascular development, vascular function, and vascular disease Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-27 Bo Liu, Huan Yang, Yong-Seok Song, Christine M. Sorenson, Nader Sheibani
Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological
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Molecular cell types as functional units of the efferent vagus nerve Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-26 Tatiana C. Coverdell, Stephen B.G. Abbott, John N. Campbell
The vagus nerve vitally connects the brain and body to coordinate digestive, cardiorespiratory, and immune functions. Its efferent neurons, which project their axons from the brainstem to the viscera, are thought to comprise “functional units” - neuron populations dedicated to the control of specific vagal reflexes or organ functions. Previous research indicates that these functional units differ from
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Vagal pathways for systemic regulation of glucose metabolism Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-26 Diba Borgmann, Henning Fenselau
Maintaining blood glucose at an appropriate physiological level requires precise coordination of multiple organs and tissues. The vagus nerve bidirectionally connects the central nervous system with peripheral organs crucial to glucose mobilization, nutrient storage, and food absorption, thereby presenting a key pathway for the central control of blood glucose levels. However, the precise mechanisms
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Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-20 Nicolas Bréchot, Alexandre Rutault, Iris Marangon, Stéphane Germain
In the human body, the 1013 blood endothelial cells (ECs) which cover a surface of 500–700 m2 (Mai et al., 2013) are key players of tissue homeostasis, remodeling and regeneration. Blood vessel ECs play a major role in the regulation of metabolic and gaz exchanges, cell trafficking, blood coagulation, vascular tone, blood flow and fluid extravasation (also referred to as blood vascular permeability)
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Death and survival from executioner caspase activation Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-18 Gongping Sun
Executioner caspases are evolutionarily conserved regulators of cell death under apoptotic stress. Activated executioner caspases drive apoptotic cell death through cleavage of diverse protein substrates or pyroptotic cell death in the presence of gasdermin E. On the other hand, activation of executioner caspases can also trigger pro-survival and pro-proliferation signals. In recent years, a growing
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Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-11
Neurons are remarkably long-lived, non-dividing cells that must maintain their functional features (e.g., electrical properties, chemical signaling) for extended periods of time – decades in humans. How neurons accomplish this incredible feat is poorly understood. Here, we review recent advances, primarily in the nematode C. elegans, that have enhanced our understanding of the molecular mechanisms
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Shedding light on mitochondrial outer-membrane permeabilization and membrane potential: State of the art methods and biosensors Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-10 Nikolay Popgeorgiev, Clara Gil, Kevin Berthenet, Giulia Bertolin, Gabriel Ichim
Membrane structural integrity is essential for optimal mitochondrial function. These organelles produce the energy needed for all vital processes, provided their outer and inner membranes are intact. This prevents the release of mitochondrial apoptogenic factors into the cytosol and ensures intact mitochondrial membrane potential (ΔΨm) to sustain ATP production. Cell death by apoptosis is generally
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Thrombospondins modulate cell function and tissue structure in the skeleton Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-07 Andrea I. Alford, Kurt D. Hankenson
Thrombospondins (TSPs) belong to a functional class of ECM proteins called matricellular proteins that are not primarily structural, but instead influence cellular interactions within the local extracellular environment. The 3D arrangement of TSPs allow interactions with other ECM proteins, sequestered growth factors, and cell surface receptors. They are expressed in mesenchymal condensations and limb
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The C. elegans anchor cell: A model to elucidate mechanisms underlying invasion through basement membrane Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-06 Isabel W. Kenny-Ganzert, David R. Sherwood
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Thrombospondin-1 in drug activity and tumor response to therapies Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-04 Elisa Longhi, Laura Carminati, Elena Carlessi, Dorina Belotti, Giulia Taraboletti
Thrombospondins (TSPs) have numerous different roles in cancer, regulating the behavior of cancer cells and non-neoplastic cells, and defining the responses of tumor cells to environmental changes, thorough their ability to orchestrate cellular and molecular interactions in the tumor microenvironment (TME). As a result of these activities, TSPs can also control drug delivery and activity, tumor response
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P-body-like condensates in the germline Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-03 Madeline Cassani, Geraldine Seydoux
P-bodies are cytoplasmic condensates that accumulate low-translation mRNAs for temporary storage before translation or degradation. P-bodies have been best characterized in yeast and mammalian tissue culture cells. We describe here related condensates in the germline of animal models. Germline P-bodies have been reported at all stages of germline development from primordial germ cells to gametes. The
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Toward a predictive understanding of epithelial cell death Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-01 Tom Cumming, Romain Levayer
Epithelial cell death is highly prevalent during development and tissue homeostasis. While we have a rather good understanding of the molecular regulators of programmed cell death, especially for apoptosis, we still fail to predict when, where, how many and which specific cells will die in a tissue. This likely relies on the much more complex picture of apoptosis regulation in a tissular and epithelial
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Building human artery and vein endothelial cells from pluripotent stem cells, and enduring mysteries surrounding arteriovenous development Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-29 Kyle M. Loh, Lay Teng Ang
Owing to their manifold roles in health and disease, there have been intense efforts to synthetically generate blood vessels in vitro from human pluripotent stem cells (hPSCs). However, there are multiple types of blood vessel, including arteries and veins, which are molecularly and functionally different. How can we specifically generate either arterial or venous endothelial cells (ECs) from hPSCs
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Pathophysiological roles of thrombospondin-4 in disease development Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-28 Karina Genaro, Z. David Luo
Thrombospondin-4 (TSP-4) belongs to the extracellular matrix glycoprotein family of thrombospondins (TSPs). The multidomain, pentameric structure of TSP-4 allows its interactions with numerous extracellular matrix components, proteins and signaling molecules that enable its modulation to various physiological and pathological processes. Characterization of TSP-4 expression under development and pathogenesis
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Anticodon stem-loop tRNA modifications influence codon decoding and frame maintenance during translation Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-28 Tyler J. Smith, Rachel N. Giles, Kristin S. Koutmou
RNAs are central to protein synthesis, with ribosomal RNA, transfer RNAs and messenger RNAs comprising the core components of the translation machinery. In addition to the four canonical bases (uracil, cytosine, adenine, and guanine) these RNAs contain an array of enzymatically incorporated chemical modifications. Transfer RNAs (tRNAs) are responsible for ferrying amino acids to the ribosome, and are
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High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-26 Andrew J. Kwok, Jianning Lu, Junzhe Huang, Bonaventure Y. Ip, Vincent C.T. Mok, Hei Ming Lai, Ho Ko
High-resolution omics, particularly single-cell and spatial transcriptomic profiling, are rapidly enhancing our comprehension of the normal molecular diversity of gliovascular cells, as well as their age-related changes that contribute to neurodegeneration. With more omic profiling studies being conducted, it is becoming increasingly essential to synthesise valuable information from the rapidly accumulating
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Cell death or survival: Insights into the role of mRNA translational control Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-23 Nupur Bhatter, Sergey E. Dmitriev, Pavel Ivanov
Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The ability of mammalian cells to regulate global protein synthesis (aka translational control) represents a critical, yet underappreciated, layer of regulation during the stress response. Various cellular stress response pathways monitor conditions of cell growth and subsequently reshape the cellular translatome
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The antagonistic relationship between apoptosis and polyploidy in development and cancer Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-16 Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary cell death mechanism that prevents polyploidy, and defects in this apoptotic response can result in polyploid cells whose subsequent error-prone chromosome segregation are a major contributor to genome instability
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Towards a molecular understanding of the 5′TOP motif in regulating translation of ribosomal mRNAs Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-12 Tobias Hochstoeger, Jeffrey A. Chao
Vertebrate cells have evolved a simple, yet elegant, mechanism for coordinated regulation of ribosome biogenesis mediated by the 5′ terminal oligopyrimidine motif (5′TOP). This motif allows cells to rapidly adapt to changes in the environment by specifically modulating translation rate of mRNAs encoding the translation machinery. Here, we provide an overview of the origin of this motif, its characterization
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Developmental heterogeneity of vascular cells: Insights into cellular plasticity in atherosclerosis? Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-12 Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Smooth muscle cells, endothelial cells and macrophages display remarkable heterogeneity within the healthy vasculature and under pathological conditions. During development, these cells arise from numerous embryological origins, which confound with different microenvironments to generate postnatal vascular cell diversity. In the atherosclerotic plaque milieu, all these cell types exhibit astonishing
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Hox genes: The original body builders Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-07 Richard S. Mann, William J. Glassford
Abstract not available
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Thrombospondins in the tumor microenvironment Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-05 James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Many cancers begin with the formation of a small nest of transformed cells that can remain dormant for years. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, a key early step in tumor progression. Over time, increases in drivers of angiogenesis predominate, and vascular cells, immune cells, and fibroblasts are recruited to the tumor mass forming a complex tissue, designated
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The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-31 Hana Fakim, Christine Vande Velde
In recent years, there has been an emphasis on the role of phase-separated biomolecular condensates, especially stress granules, in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). This is largely due to several ALS-associated mutations occurring in genes involved in stress granule assembly and observations that pathological inclusions detected in ALS patient neurons contain
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Emerging functions of thrombospondin-1 in immunity Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-29 Sukhbir Kaur, David D. Roberts
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-29
Abstract not available