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Reconstitution of cytolinker-mediated crosstalk between actin and vimentin Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-03-12 Irene Istúriz Petitjean, Quang D. Tran, Angeliki Goutou, Zima Kabir, Gerhard Wiche, Cécile Leduc, Gijsje H. Koenderink
Cell shape and motility are determined by the cytoskeleton, an interpenetrating network of actin filaments, microtubules, and intermediate filaments. The biophysical properties of each filament type individually have been studied extensively by cell-free reconstitution. By contrast, the interactions between the three cytoskeletal networks are relatively unexplored. They are coupled via crosslinkers
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Actin-membrane linkers: Insights from synthetic reconstituted systems Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-03-01 Feng-Ching Tsai, Gwendal Guérin, Julien Pernier, Patricia Bassereau
At the cell surface, the actin cytoskeleton and the plasma membrane interact reciprocally in a variety of processes related to the remodeling of the cell surface. The actin cytoskeleton has been known to modulate membrane organization and reshape the membrane. To this end, actin-membrane linking molecules play a major role in regulating actin assembly and spatially direct the interaction between the
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Cross-regulation of Listeria monocytogenes and the host ubiquitin system in listeriosis Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-02-28 Yuan Zhuang, Johanna B. Fischer, Gopala Nishanth, Dirk Schlüter
The facultative intracellular bacterium (.) may cause severe diseases in humans and animals. The control of listeriosis/ requires the concerted action of cells of the innate and adaptive immune systems. In this regard, cell-intrinsic immunity of infected cells, activated by the immune responses, is crucial for the control and elimination intracellular . Both the immune response against and cell intrinsic
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NANOS1 restricts oral cancer cell motility and TGF-ß signaling Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-02-21 Julia Rosemann, Jonas Pyko, Roland Jacob, Jana Macho, Matthias Kappler, Alexander W. Eckert, Monika Haemmerle, Tony Gutschner
Oral squamous cell carcinoma (OSCC) is the most frequent type of cancer of the head and neck area accounting for approx. 377,000 new cancer cases every year. The epithelial-to-mesenchymal transition (EMT) program plays an important role in OSCC progression and metastasis therefore contributing to a poor prognosis in patients with advanced disease. Transforming growth factor beta (TGF-ß) is a powerful
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Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-02-20 Carolin Berwanger, Dominic Terres, Dominik Pesta, Britta Eggers, Katrin Marcus, Ilka Wittig, Rudolf J. Wiesner, Rolf Schröder, Christoph S. Clemen
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Deletion of exons 2 and 3 from Actb and cell immortalization lead to widespread, β-actin independent alterations in gene expression associated with cell cycle control Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-02-15 Lauren J. Sundby, William M. Southern, Jiao Sun, Xiaobai Patrinostro, Wei Zhang, Jeongsik Yong, James M. Ervasti
The cytoplasmic actin proteins, β- and γ-actin, are 99% identical but thought to perform non-redundant functions. The nucleotide coding regions of cytoplasmic actin genes, and , are 89% identical. Knockout (KO) of by Cre-mediated deletion of first coding exons 2 and 3 in mice is embryonic lethal and fibroblasts derived from KO embryos (MEFs) fail to proliferate. In contrast, KO MEFs display with a
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Molecular mechanisms of naringenin modulation of mitochondrial permeability transition acting on F1FO-ATPase and counteracting saline load-induced injury in SHRSP cerebral endothelial cells Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-02-15 Salvatore Nesci, Cristina Algieri, Matteo Antonio Tallarida, Rosita Stanzione, Saverio Marchi, Donatella Pietrangelo, Fabiana Trombetti, Luca D’Ambrosio, Maurizio Forte, Maria Cotugno, Ilaria Nunzi, Rachele Bigi, Loredana Maiuolo, Antonio De Nino, Paolo Pinton, Giovanni Romeo, Speranza Rubattu
Naringenin (NRG) was characterized for its ability to counteract mitochondrial dysfunction which is linked to cardiovascular diseases. The FF-ATPase can act as a molecular target of NRG. The interaction of NRG with this enzyme can avoid the energy transmission mechanism of ATP hydrolysis, especially in the presence of Ca cation used as cofactor. Indeed, NRG was a selective inhibitor of the hydrophilic
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Physico-chemical characterization of the tumour microenvironment of pancreatic ductal adenocarcinoma Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-02-12 Elena García-Gareta, Alejandro Calderón-Villalba, Pilar Alamán-Díez, Carlos Gracia Costa, Pedro Enrique Guerrero, Carlota Mur, Ana Rueda Flores, Nerea Olivera Jurjo, Patricia Sancho, María Ángeles Pérez, José Manuel García-Aznar
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy that accounts for more than 90% of pancreatic cancer diagnoses. Our research is focused on the physico-chemical properties of the tumour microenvironment (TME), including its tumoural extracellular matrix (tECM), as they may have an important impact on the success of cancer therapies. PDAC xenografts and their decellularized
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Thrombospondin 4, a mediator and candidate indicator of pain Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-02-06 Yanqiong Wu, Min Yang, Xueqin Xu, Yan Gao, Xiaohui Li, Yang Li, Shanchun Su, Xianqiao Xie, Zeyong Yang, Changbin Ke
Pain is the most common symptom for which patients seek medical attention. Existing treatments for pain control are largely ineffective due to the lack of an accurate way to objectively measure pain intensity and a poor understanding of the etiology of pain. Thrombospondin 4(TSP4), a member of the thrombospondin gene family, is expressed in neurons and astrocytes and induces pain by interacting with
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The nexus of nuclear envelope dynamics, circular economy and cancer cell pathophysiology Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-02-05 Kristina Keuper, Jiri Bartek, Apolinar Maya-Mendoza
The nuclear envelope (NE) is a critical component in maintaining the function and structure of the eukaryotic nucleus. The NE and lamina are disassembled during each cell cycle to enable an open mitosis. Nuclear architecture construction and deconstruction is a prime example of a circular economy, as it fulfills a highly efficient recycling program bound to continuous assessment of the quality and
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High throughput methods to study protein-protein interactions during host-pathogen interactions Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-01-24 Giridhar Chandrasekharan, Meera Unnikrishnan
The ability of a pathogen to survive and cause an infection is often determined by specific interactions between the host and pathogen proteins. Such interactions can be both intra- and extracellular and may define the outcome of an infection. There are a range of innovative biochemical, biophysical and bioinformatic techniques currently available to identify protein-protein interactions (PPI) between
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Regulation of the HIF switch in human endothelial and cancer cells Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-01-20 Jakub Slawski, Maciej Jaśkiewicz, Anna Barton, Sylwia Kozioł, James F. Collawn, Rafał Bartoszewski
Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome for cells to survive hypoxic insults and oxidative stress. They are important during embryonic development and reprogram the cells to utilize glycolysis when the oxygen levels are extremely low. This metabolic change facilitates normal cell survival as well as cancer cell survival. The key feature in survival
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Corrigendum to “Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H2O2 and iron” [Eur. J. Cell Biol. 102 (2023) 151346] Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-01-15 M. Suzuki-Karasaki, Y. Ochiai, S. Innami, H. Okajima, H. Nakayama, Y. Suzuki-Karasaki
Abstract not available
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Helical motors and formins synergize to compact chiral filopodial bundles: A theoretical perspective Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-01-11 Ondrej Maxian, Alex Mogilner
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Controling the cytoskeleton during CEACAM3-mediated phagocytosis Eur. J. Cell Biol. (IF 6.6) Pub Date : 2024-01-05 Johannes W.P. Kuiper, Helena L. Gregg, Meike Schüber, Jule Klein, Christof R. Hauck
Phagocytosis, an innate defense mechanism of multicellular animals, is initiated by specialized surface receptors. A phagocytic receptor expressed by human polymorphonuclear granulocytes, the major professional phagocytes in our body, is one of the fastest evolving human proteins implying a special role in human biology. This receptor, CEACAM3, is a member of the CarcinoEmbryonic Antigen-related Cell
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Shigella generates distinct IAM subpopulations during epithelial cell invasion to promote efficient intracellular niche formation Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-12-29 Lisa Sanchez, Arthur Lensen, Michael G. Connor, Mélanie Hamon, Jost Enninga, Camila Valenzuela
The facultative intracellular pathogen Shigella flexneri invades non-phagocytic epithelial gut cells. Through a syringe-like apparatus called type 3 secretion system, it injects effector proteins into the host cell triggering actin rearrangements leading to its uptake within a tight vacuole, termed the bacterial-containing vacuole (BCV). Simultaneously, Shigella induces the formation of large vesicles
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A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-12-28 Philipp Radler, Martin Loose
Bacteria divide by binary fission. The protein machine responsible for this process is the divisome, a transient assembly of more than 30 proteins in and on the surface of the cytoplasmic membrane. Together, they constrict the cell envelope and remodel the peptidoglycan layer to eventually split the cell into two. For Escherichia coli, most molecular players involved in this process have probably been
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Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-12-27 Dante Barreda, Sergio Grinstein, Spencer A. Freeman
The ongoing phagocytic activity of macrophages necessitates an extraordinary capacity to digest and resolve incoming material. While the initial steps leading to the formation of a terminal phagolysosome are well studied, much less is known about the later stages of this process, namely the degradation and resolution of the phagolysosomal contents. We report that the degradation of targets such as
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Cofilin-mediated actin filament network flexibility facilitates 2D to 3D actomyosin shape change Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-12-26 Zachary Gao Sun, Vikrant Yadav, Sorosh Amiri, Wenxiang Cao, Enrique M. De La Cruz, Michael Murrell
The organization of actin filaments (F-actin) into crosslinked networks determines the transmission of mechanical stresses within the cytoskeleton and subsequent changes in cell and tissue shape. Principally mediated by proteins such as α-actinin, F-actin crosslinking increases both network connectivity and rigidity, thereby facilitating stress transmission at low crosslinking yet attenuating transmission
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Direct observation of cortactin protecting Arp2/3-actin filament branch junctions from GMF-mediated destabilization Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-12-05 Emma R. McGuirk, Neha Koundinya, Priyashree Nagarajan, Shae B. Padrick, Bruce L. Goode
How cells tightly control the formation and turnover of branched actin filament arrays to drive cell motility, endocytosis, and other cellular processes is still not well understood. Here, we investigated the mechanistic relationship between two binding partners of the Arp2/3 complex, glia maturation factor (GMF) and cortactin. Individually, GMF and cortactin have opposite effects on the stability
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Impact of heat and cold shock on epigenetics and chromatin structure Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-11-23 Claudio Casali, Luca Galgano, Lorena Zannino, Stella Siciliani, Margherita Cavallo, Giuliano Mazzini, Marco Biggiogera
Cells are continuously exposed to various sources of insults, among which temperature variations are extremely common. Epigenetic mechanisms, critical players in gene expression regulation, undergo alterations due to these stressors, potentially leading to health issues. Despite the significance of DNA methylation and histone modifications in gene expression regulation, their changes following heat
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Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-11-19 M.J. Nunes, A.N. Carvalho, C. Sá-Lemos, M. Colaço, I. Cervenka, V. Ciraci, S.G. Santos, M.M. Ribeiro, M. Castanheira, P.R. Jannig, M.J. Gama, M. Castro-Caldas, C.M.P. Rodrigues, E. Rodrigues, J.L. Ruas
Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) transcriptional coactivators are key regulators of energy metabolism-related genes and are expressed in energy-demanding tissues. There are several PGC-1α variants with different biological functions in different tissues. The brain is one of the tissues where the role of PGC-1α isoforms remains less explored. Here, we used a toxin-based
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Rel governs loser elimination during stem cell competition in the Drosophila testis Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-11-18 Silvana Hof-Michel, Ljubinka Cigoja, Sabina Huhn, Christian Bökel
In the Drosophila testis, a group of stromal cells termed hub provides multiple niche signals for the surrounding germline and somatic stem cells. Stem cells of both populations compete for physical retention in the niche, and clones unable to transduce any one niche signal are rapidly eliminated from the stem cell pool by differentiation. We have mapped the transcriptomes of isolated somatic cyst
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Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1 Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-11-22 Mohamed Kodiha, Nabila Azad, Siwei Chu, Noah Crampton, Ursula Stochaj
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Extracellular vesicles on the move: Traversing the complex matrix of tissues Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-11-11 Syrine Arif, Véronique J. Moulin
Extracellular vesicles are small particles involved in intercellular signaling. They are produced by virtually all cell types, transport biological molecules, and are released into the extracellular space. Studies on extracellular vesicles have become more numerous in recent years, leading to promising research on their potential impact on health and disease. Despite significant progress in understanding
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Modelling Legionnaires’ disease: Lessons learned from invertebrate and vertebrate animal models Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-10-31 Clarisse Leseigneur, Carmen Buchrieser
The study of virulence of Legionella pneumophila and its interactions with its hosts has been predominantly conducted in cellulo in the past decades. Although easy to implement and allowing the dissection of molecular pathways underlying host-pathogen interactions, these cellular models fail to provide conditions of the complex environments encountered by the bacteria during the infection of multicellular
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Beyond uniformity: Exploring the heterogeneous and dynamic nature of the microtubule lattice Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-10-29 Mariana Romeiro Motta, Subham Biswas, Laura Schaedel
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Reconstitution of actin-based cellular processes: Why encapsulation changes the rules Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-10-30 Fabina Binth Kandiyoth, Alphée Michelot
While in vitro reconstitution of cellular processes is progressing rapidly, the encapsulation of biomimetic systems to reproduce the cellular environment is a major challenge. Here we review the difficulties, using reconstitution of processes dependent on actin polymerization as an example. Some of the problems are purely technical, due to the need for engineering strategies to encapsulate concentrated
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MitoTracker: A useful tool in need of better alternatives Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-10-31 Kit Neikirk, Andrea G. Marshall, Bartosz Kula, Nathan Smith, Sharonda LeBlanc, Antentor Hinton
The fluorescence viewing of mitochondria is commonly performed by MitoTracker, a lipophilic cationic dye that is taken up by the mitochondria. In this forum, we highlight several issues that may occur with MitoTracker, including staining of other organelles. Our aim is to offer alternative dyes and discuss their advantages and disadvantages. We also offer options for software with alternatives to MitoTracker
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Microtubule rescue control by drugs and MAPs examined with in vitro pedestal assay Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-10-17 Mikhail N. Anisimov, Alena V. Korshunova, Vladimir V. Popov, Nikita B. Gudimchuk
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Reconstitution of the transition from a lamellipodia- to filopodia-like actin network with purified proteins Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-10-20 Cristian Suarez, Jonathan D. Winkelman, Alyssa J. Harker, Hannah J. Ye, Patrick M. McCall, Alisha N. Morganthaler, Margaret L. Gardel, David R. Kovar
How cells utilize complex mixtures of actin binding proteins to assemble and maintain functionally diverse actin filament networks with distinct architectures and dynamics within a common cytoplasm is a longstanding question in cell biology. A compelling example of complex and specialized actin structures in cells are filopodia which sense extracellular chemical and mechanical signals to help steer
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Call to action to properly utilize electron microscopy to measure organelles to monitor disease Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-10-16 Kit Neikirk, Edgar-Garza Lopez, Andrea G. Marshall, Ahmad Alghanem, Evan Krystofiak, Bartosz Kula, Nathan Smith, Jianqiang Shao, Prasanna Katti, Antentor Hinton
This review provides an overview of the current methods for quantifying mitochondrial ultrastructure, including cristae morphology, mitochondrial contact sites, and recycling machinery and a guide to utilizing electron microscopy to effectively measure these organelles. Quantitative analysis of mitochondrial ultrastructure is essential for understanding mitochondrial biology and developing therapeutic
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A bacterial effector protein promotes nuclear translocation of Stat3 to induce IL-10 Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-10-02 Laura Berneking, Indra Bekere, Sören Rob, Marie Schnapp, Jiabin Huang, Klaus Ruckdeschel, Martin Aepfelbacher
The multifunctional Yersinia effector YopM inhibits effector triggered immunity and increases production of the anti-inflammatory cytokine Interleukin-10 (IL-10) to suppress the host immune response. Previously it was shown that YopM induces IL-10 gene expression by elevating phosphorylation of the serine-threonine kinase RSK1 in the nucleus of human macrophages. Using transcriptomics, we found that
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Purification of modified mammalian actin isoforms for in vitro reconstitution assays Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-09-28 David J. Kast, Silvia Jansen
In vitro reconstitution assays using purified actin have greatly improved our understanding of cytoskeletal dynamics and their regulation by actin-binding proteins. However, early purification methods consisted of harsh conditions to obtain pure actin and often did not include correct maturation and obligate modification of the isolated actin monomers. Novel insights into the folding requirements and
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Loss of mfsd8 alters the secretome during Dictyostelium aggregation Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-09-19 Robert J. Huber, Joshua Gray, William D. Kim
Major facilitator superfamily domain-containing protein 8 (MFSD8) is a transmembrane protein that has been reported to function as a lysosomal chloride channel. In humans, homozygous mutations in MFSD8 cause a late-infantile form of neuronal ceroid lipofuscinosis (NCL) called CLN7 disease. In the social amoeba Dictyostelium discoideum, Mfsd8 localizes to cytoplasmic puncta and vesicles, and regulates
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Concept of lipid droplet biogenesis Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-09-19 R.Mankamna Kumari, Amit Khatri, Ritika Chaudhary, Vineet Choudhary
Lipid droplets (LD) are functionally conserved fat storage organelles found in all cell types. LDs have a unique structure comprising of a hydrophobic core of neutral lipids (fat), triacylglycerol (TAG) and cholesterol esters (CE) surrounded by a phospholipid monolayer. LD surface is decorated by a multitude of proteins and enzymes rendering this compartment functional. Accumulating evidence suggests
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N-glycosylation at N57/100/110 affects CD44s localization, function and stability in hepatocellular carcinoma Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-09-09 Qixiang Cheng, Xibo Hu, Xiaoqing Zhang, Depeng Yang, Guiping Zhao, Liping Sun, Meiyi Jiang, Lijun Yang, Jialing Cai, Bing Wang, Mengmeng Zhang, Fang Han, Yu Li, Huan Nie
The glycosylation levels of proteins in cancer cells are closely related to cancer invasion and migration. CD44 is a transmembrane glycoprotein that is significantly overexpressed in a variety of tumor cells and has been proven to promote the migration and motility of cancer cells, but the effect of its N-glycosylation modification on CD44 protein function in tumors is less studied. Here, we investigated
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Regulation of integrin α5β1-mediated Staphylococcus aureus cellular invasion by the septin cytoskeleton Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-09-03 Stevens Robertin, Dominik Brokatzky, Damián Lobato-Márquez, Serge Mostowy
Staphylococcus aureus, a Gram-positive bacterial pathogen, is an urgent health threat causing a wide range of clinical infections. Originally viewed as a strict extracellular pathogen, accumulating evidence has revealed S. aureus to be a facultative intracellular pathogen subverting host cell signalling to support invasion. The majority of clinical isolates produce fibronectin-binding proteins A and
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RhoB promotes Salmonella survival by regulating autophagy Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-30 Marco Kirchenwitz, Jessica Halfen, Kristin von Peinen, Silvia Prettin, Jana Kollasser, Susanne zur Lage, Wulf Blankenfeldt, Cord Brakebusch, Klemens Rottner, Anika Steffen, Theresia E.B. Stradal
Salmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and –E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking
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Visualizing the subcellular localization of RHOB-GTP and GTPase-Effector complexes using a split-GFP/nanobody labelling assay Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-21 Sebastian Castillo, Rémi Gence, Delphine Pagan, Faten Koraïchi, Catherine Bouchenot, Benoit J. Pons, Betty Boëlle, Aurélien Olichon, Isabelle Lajoie-Mazenc, Gilles Favre, Jean-Denis Pédelacq, Stéphanie Cabantous
Small GTPases are highly regulated proteins that control essential signaling pathways through the activity of their effector proteins. Among the RHOA subfamily, RHOB regulates peculiar functions that could be associated with the control of the endocytic trafficking of signaling proteins. Here, we used an optimized assay based on tripartite split-GFP complementation to localize GTPase-effector complexes
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Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-24 Anika Heinze, Marco B. Rust
Dendritic spines form the postsynaptic compartment of most excitatory synapses in the vertebrate brain. Morphological changes of dendritic spines contribute to major forms of synaptic plasticity such as long-term potentiation (LTP) or depression (LTD). Synaptic plasticity underlies learning and memory, and defects in synaptic plasticity contribute to the pathogeneses of human brain disorders. Hence
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Get a grip: Podosomes as potential players in phagocytosis Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-22 Stefan Linder, Bryan Barcelona
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Novel insights into the pharmacological modulation of human periodontal ligament stem cells by the amino-bisphosphonate Alendronate Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-15 Anna Di Vito, Emanuela Chiarella, Jessica Sovereto, Jessica Bria, Ida Daniela Perrotta, Alessandro Salatino, Francesco Baudi, Alessandro Sacco, Alessandro Antonelli, Flavia Biamonte, Tullio Barni, Amerigo Giudice
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The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-05 Andrew T. Phillips, Edward F. Boumil, Arunkumar Venkatesan, Christine Tilstra-Smith, Nileyma Castro, Barry E. Knox, Jessica L. Henty-Ridilla, Audrey M. Bernstein
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Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H2O2 and iron Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-03 Manami Suzuki-Karasaki, Yushi Ochiai, Shizuka Innami, Hiroshi Okajima, Miki Suzuki-Karasaki, Hideki Nakayama, Yoshihiro Suzuki-Karasaki
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Recent advances in plant cell biology Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-02 Bénédicte Desvoyes, Crisanto Gutierrez
Abstract not available
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Three-dimensional chromatin architecture in plants – General features and novelties Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-08-01 Edouard Tourdot, Stefan Grob
Research on the three-dimensional (3D) structure of the genome and its distribution within the nuclear space has made a big leap in the last two decades. Work in the animal field has led to significant advances in our general understanding on eukaryotic genome organization. This did not only bring along insights into how the 3D genome interacts with the epigenetic landscape and the transcriptional
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3D environment controls H3K4 methylation and the mechanical response of the nucleus in acute lymphoblastic leukemia cells Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-07-23 Raquel González-Novo, Ana de Lope-Planelles, María Pilar Cruz Rodríguez, África González-Murillo, Elena Madrazo, David Acitores, Mario García de Lacoba, Manuel Ramírez, Javier Redondo-Muñoz
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Leptin deficiency impairs adipogenesis and browning response in mouse mesenchymal progenitors Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-07-13
Although phenotypically different, brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) are able to produce heat through non-shivering thermogenesis due to the presence of mitochondrial uncoupling protein 1 (UCP1). The appearance of thermogenically active beige adipocytes in iWAT is known as browning. Both brown and beige cells originate from mesenchymal stem cells (MSCs), and in culture
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ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-07-13
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Clones of aging: When better fitness can be dangerous Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-07-06 Fabio Marongiu, Samuele Cheri, Ezio Laconi
The biological and clinical significance of aberrant clonal expansions in aged tissues is being intensely discussed. Evidence is accruing that these clones often result from the normal dynamics of cell turnover in our tissues. The aged tissue microenvironment is prone to favour the emergence of specific clones with higher fitness partly because of an overall decline in cell intrinsic regenerative potential
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Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-07-06 Vijay Kumar, Caitlin Bauer, John H. Stewart
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Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-07-06 Naava Naslavsky, Steve Caplan
Despite their significance in receptor-mediated internalization and continued signal transduction in cells, early/sorting endosomes (EE/SE) remain incompletely characterized, with many outstanding questions that surround the dynamics of their size and number. While several studies have reported increases in EE/SE size and number resulting from endocytic events, few studies have addressed such dynamics
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Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-06-26 Javad Alizadeh, Simone C. da Silva Rosa, Xiaohui Weng, Joadi Jacobs, Shahrokh Lorzadeh, Amir Ravandi, Rui Vitorino, Stevan Pecic, Aleksandra Zivkovic, Holger Stark, Shahla Shojaei, Saeid Ghavami
Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides’ fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of
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Vitamin D3 protects against respiratory syncytial virus-induced barrier dysfunction in airway epithelial cells via PKA signaling pathway Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-06-22 Nannan Gao, Andjela Raduka, Fariba Rezaee
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection in infants and young children globally and is responsible for hospitalization and mortality in the elderly population. Virus-induced airway epithelial barrier damage is a critical step during RSV infection, and emerging studies suggest that RSV disrupts the tight junctions (TJs) and adherens junctions
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Biological roles of plant synaptotagmins Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-06-20 Francisco Benitez-Fuente, Miguel A. Botella
Plant synaptotagmins (SYTs) are resident proteins of the endoplasmic reticulum (ER). They are characterized by an N-terminal transmembrane region and C2 domains at the C-terminus, which tether the ER to the plasma membrane (PM). In addition to their tethering role, SYTs contain a lipid-harboring SMP domain, essential for shuttling lipids between the ER and the PM. There is now abundant literature on
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Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-06-17 N. Nojszewska, O. Idilli, D. Sarkar, Z. Ahouiyek, Y. Arroyo-Berdugo, C. Sandoval, MS Amin-Anjum, S. Bowers, D. Greaves, L. Saeed, M. Khan, S. Salti, S. Al-Shami, H. Topoglu, JK Punzalan, JG Farias, Y. Calle
The development of epithelial-to-mesenchymal transition (EMT) like features is emerging as a critical factor involved in the pathogenesis of acute myeloid leukaemia (AML). However, the extracellular signals and the signalling pathways in AML that may regulate EMT remain largely unstudied. We found that the bone marrow (BM) mesenchymal/fibroblastic cell line HS5 induces an EMT-like migratory phenotype
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The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferation, differentiation and migration in the ocular and central nervous system Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-06-10 Paulo F. Santos, Beatriz Fazendeiro, Francis C. Luca, António Francisco Ambrósio, Hélène Léger
Nuclear Dbf2-related (NDR) kinases are a subgroup of evolutionarily conserved AGC protein kinases that regulate various aspects of cell growth and morphogenesis. There are 4 NDR protein kinases in mammals, LATS1, LATS2 and STTK8/NDR1, STK38L/NDR2 protein kinases. LATS1 and 2 are core components of the well-studied Hippo pathway, which play a critical role in the regulation of cell proliferation, differentiation
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Stress-induced senescence in mesenchymal stem cells: Triggers, hallmarks, and current rejuvenation approaches Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-06-07 Sunny Shinchen Lee, Thu Thuy Vũ, Anthony S. Weiss, Giselle C. Yeo
Mesenchymal stem cells (MSCs) have emerged as promising cell-based therapies in the treatment of degenerative and inflammatory conditions. However, despite accumulating evidence of the breadth of MSC functional potency, their broad clinical translation is hampered by inconsistencies in therapeutic efficacy, which is at least partly due to the phenotypic and functional heterogeneity of MSC populations
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Depletion of intracellular Ca2+ induces FOXM1 SUMOylation and accumulation on the inner nuclear membrane and accelerates G2/M cell cycle transition Eur. J. Cell Biol. (IF 6.6) Pub Date : 2023-06-08 Tzu-Chien Lin, Ping-Jung Chung, Chen-An Shen, Thi My Hang Nguyen, Yi-Syuan Lin, Shih-Chieh Lin, Shih-Chuan Hsiao, Wen-Tai Chiu