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The distribution of eukaryotic initiation factor 4E after bouts of resistance exercise is altered by shortening of recovery periods J. Physiol. Sci. (IF 2.955) Pub Date : 2020-11-04 Junya Takegaki,Riki Ogasawara,Karina Kouzaki,Satoshi Fujita,Koichi Nakazato,Naokata Ishii
Insufficient duration of recovery between resistance exercise bouts reduces the effects of exercise training, but the influence on muscle anabolic responses is not fully understood. Here, we investigated the changes in the distribution of eukaryotic initiation factor (eIF) 4E, a key regulator of translation initiation, and related factors in mouse skeletal muscle after three successive bouts of resistance
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Effectiveness of impedance parameters for muscle quality evaluation in healthy men J. Physiol. Sci. (IF 2.955) Pub Date : 2020-10-31 Hiroki Sato,Takao Nakamura,Toshimasa Kusuhara,Kobara Kenichi,Katsushi Kuniyasu,Takaki Kawashima,Kozo Hanayama
We investigated the relationship between impedance parameters and skeletal muscle function in the lower extremities, as well as the effectiveness of impedance parameters in evaluating muscle quality. Lower extremity impedance of 19 healthy men (aged 23–31 years) measured using the direct segmental multi-frequency bioelectrical impedance analysis were arc-optimized using the Cole–Cole model, following
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Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton J. Physiol. Sci. (IF 2.955) Pub Date : 2020-10-31 Tomonori Okazaki,Daichi Saito,Masatoshi Inden,Kotoku Kawaguchi,Sayuri Wakimoto,Takashi Nakahari,Shinji Asano
Moesin is a member of the ezrin, radixin and moesin (ERM) proteins that are involved in the formation and/or maintenance of cortical actin organization through their cross-linking activity between actin filaments and proteins located on the plasma membranes as well as through regulation of small GTPase activities. Microglia, immune cells in the central nervous system, show dynamic reorganization of
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Correction to: Hepatocyte growth factor inhibits TGF-β1-induced myofibroblast differentiation in tendon fibroblasts: role of AMPK signaling pathway J. Physiol. Sci. (IF 2.955) Pub Date : 2020-10-26 Qingbo Cui,Songbin Fu,Zhaozhu Li
An amendment to this paper has been published and can be accessed via the original article.
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NK cell-derived exosomes improved lung injury in mouse model of Pseudomonas aeruginosa lung infection J. Physiol. Sci. (IF 2.955) Pub Date : 2020-10-23 Ruiqi Jia,Kuili Cui,Zhenkui Li,Yuan Gao,Bianfang Zhang,Zhixia Wang,Junwei Cui
Background Pseudomonas aeruginosa ( PA ) is one of the most common bacteria that causes lung infection in hospital. The aim of our study is to explore the role and action mechanism of NK cells in lung PA infection. Methods In this present study, 2.5 × 108 CFU/mouse PA was injected into murine trachea to make lung PA infection mouse model. Anti-asialo GM1 was used to inhibit NK cell. The percentage
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Expression and functions of N-type Cav2.2 and T-type Cav3.1 channels in rat vasopressin neurons under normotonic conditions J. Physiol. Sci. (IF 2.955) Pub Date : 2020-10-15 Kaori Sato-Numata,Tomohiro Numata,Yoichi Ueta,Yasunobu Okada
Arginine vasopressin (AVP) neurons play essential roles in sensing the change in systemic osmolarity and regulating AVP release from their neuronal terminals to maintain the plasma osmolarity. AVP exocytosis depends on the Ca2+ entry via voltage-gated Ca2+ channels (VGCCs) in AVP neurons. In this study, suppression by siRNA-mediated knockdown and pharmacological sensitivity of VGCC currents evidenced
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The relationship between olfaction and cognitive function in the elderly J. Physiol. Sci. (IF 2.955) Pub Date : 2020-10-14 Sae Uchida,Chiho Shimada,Naoko Sakuma,Fusako Kagitani,Akiko Kan,Shuichi Awata
This study investigated the relationship between olfaction and cognitive function in 12 elderly people (age: 80.9 ± 1.6) living in the community. Olfactory function was assessed by the identification threshold for rose odor. Four cognitive measures consisting general cognitive ability assessed by Mini-Mental State Examination (MMSE), its sub-domains, and attentional ability assessed by drawing a line
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TRPM7 silencing attenuates Mg 2+ influx in cardiac myoblasts, H9c2 cells J. Physiol. Sci. (IF 2.955) Pub Date : 2020-10-07 Michiko Tashiro,Masato Konishi,Ryo Kobayashi,Hana Inoue,Utako Yokoyama
TRPM7, a member of the melastatin subfamily of transient receptor potential channels, is suggested to be a potential candidate for a physiological Mg2+ channel. However, there is no direct evidence of Mg2+ permeation through endogenous TRPM7. To determine the physiological roles of TRPM7 in intracellular Mg2+ homeostasis, we measured the cytoplasmic free Mg2+ concentration ([Mg2+]i) in TRPM7-silenced
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Electrophysiological investigation of the contribution of attention to altered pain inhibition processes in patients with irritable bowel syndrome J. Physiol. Sci. (IF 2.955) Pub Date : 2020-10-06 Nabi Rustamov,Alice Wagenaar-Tison,Elysa Doyer,Mathieu Piché
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with chronic abdominal pain and altered pain processing. The aim of this study was to examine whether attentional processes contribute to altered pain inhibition processes in patients with IBS. Nine female patients with IBS and nine age-/sex-matched controls were included in a pain inhibition paradigm using counter-stimulation
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Effect of the parasympathetic vasodilation on temperature regulation via trigeminal afferents in the orofacial area J. Physiol. Sci. (IF 2.955) Pub Date : 2020-03-31 Hanako Ohke,Toshiya Sato,Kohei Mito,Makoto Terumitsu,Hisayoshi Ishii
The skin temperature ( T m) of the orofacial area influences orofacial functions and is related to the blood flow (BF). Marked increases in BF mediated by parasympathetic vasodilation may be important for orofacial T m regulation. Therefore, we examined the relationship between parasympathetic reflex vasodilation and orofacial T m in anesthetized rats. Electrical stimulation of the central cut end
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Effect of coronary artery bypass grafting on blood pressure response to head-up tilting J. Physiol. Sci. (IF 2.955) Pub Date : 2020-03-30 Shinnosuke Hori,Yoshi-ichiro Kamijo,Mitsuru Yuzaki,Tetsuya Kawabe,Kohei Minami,Yasunori Umemoto,Mao Yokoyama,Hiroyasu Uenishi,Yoshiharu Nishimura,Ken Kouda,Yukio Mikami,Fumihiro Tajima
Blood pressure response to head-up tilt (HUT) in 7 healthy subjects and 9 patients before and after coronary artery bypass grafting (CABG) was measured during supine and 15-min 60° HUT. Stroke volume (SV) and ejection fraction (EF) were assessed by echocardiography. Baseline mean arterial pressure (MAP) and heart rate (HR) in patients before CABG were similar to healthy subjects. MAP in patients decreased
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Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward K + channel expression in pluripotent P19 cell-derived cardiomyocytes J. Physiol. Sci. (IF 2.955) Pub Date : 2020-03-25 Tomoko Uchino,Ming-Qi Zheng,Yan Wang,Katsushige Ono
The homeobox-containing gene Csx/Nkx2.5 codes several cardiac transcription factors and plays a critical role in early cardiogenesis. We investigated the effect of Csx/Nkx2.5 on the expression of cardiac ion channels using P19-derived cardiomyocytes. P19CL6 cells and P19CL6 cells with Csx/Nkx2.5 overexpression (P19CL6-Csx cells) were induced to differentiate into cardiomyocytes by treatment with dimethyl
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Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats J. Physiol. Sci. (IF 2.955) Pub Date : 2020-03-24 Ghazaleh Omidi,Arezoo Rezvani-Kamran,Ahmad Ganji,Somayeh Komaki,Farshid Etaee,Masoumeh Asadbegi,Alireza Komaki
High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum ( H. ) scabrum extract (Ext) contains compounds that could treat neurological disorders. This study aimed to examine the neuroprotective impacts of the H. scabrum Ext on hippocampal synaptic plasticity in rats that were fed HFD. Fifty-four male Wistar rats (220 ± 10 g) were
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Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice J. Physiol. Sci. (IF 2.955) Pub Date : 2020-03-19 Shahidul Islam,Kazuaki Yoshioka,Sho Aki,Kazuhiro Ishimaru,Hiroki Yamada,Noriko Takuwa,Yoh Takuwa
Class II phosphatidylinositol 3-kinases (PI3K), PI3K-C2α and PI3K-C2β, are involved in cellular processes including endocytosis, cilia formation and autophagy. However, the role of PI3K-C2α and PI3K-C2β at the organismal level is not well understood. We found that double knockout (KO) mice with both smooth muscle-specific KO of PI3K-C2α and global PI3K-C2β KO, but not single KO mice of either PI3K-C2α
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Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment J. Physiol. Sci. (IF 2.955) Pub Date : 2020-03-14 Hironobu Morita,Hiroshi Kaji,Yoichi Ueta,Chikara Abe
The peripheral vestibular organs are sensors for linear acceleration (gravity and head tilt) and rotation. Further, they regulate various body functions, including body stability, ocular movement, autonomic nerve activity, arterial pressure, body temperature, and muscle and bone metabolism. The gravitational environment influences these functions given the highly plastic responsiveness of the vestibular
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Respiratory pattern and phrenic and hypoglossal nerve activity during normoxia and hypoxia in 6-OHDA-induced bilateral model of Parkinson’s disease J. Physiol. Sci. (IF 2.955) Pub Date : 2020-03-11 Kryspin Andrzejewski,Monika Jampolska,Małgorzata Zaremba,Ilona Joniec-Maciejak,Paweł M. Boguszewski,Katarzyna Kaczyńska
Respiratory disturbances present in Parkinson’s disease (PD) are not well understood. Thus, studies in animal models aimed to link brain dopamine (DA) deficits with respiratory impairment are needed. Adult Wistar rats were lesioned with injection of 6-hydroxydopamine (6-OHDA) into the third cerebral ventricle. Two weeks after hypoxic test was performed in whole-body plethysmography chamber, phrenic
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Males benefit more from cold water immersion during repeated handgrip contractions than females despite similar oxygen kinetics J. Physiol. Sci. (IF 2.955) Pub Date : 2020-03-05 Jiří Baláš,Jan Kodejška,Dominika Krupková,David Giles
The purpose of the present study was to assess the effect of different water immersion temperatures on handgrip performance and haemodynamic changes in the forearm flexors of males and females. Twenty-nine rock-climbers performed three repeated intermittent handgrip contractions to failure with 20 min recovery on three separate laboratory visits. For each visit, a randomly assigned recovery strategy
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Mechano-calcium and mechano-electric feedbacks in the human cardiomyocyte analyzed in a mathematical model. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-02-18 Nathalie A Balakina-Vikulova,Alexander Panfilov,Olga Solovyova,Leonid B Katsnelson
Experiments on animal hearts (rat, rabbit, guinea pig, etc.) have demonstrated that mechano-calcium feedback (MCF) and mechano-electric feedback (MEF) are very important for myocardial self-regulation because they adjust the cardiomyocyte contractile function to various mechanical loads and to mechanical interactions between heterogeneous myocardial segments in the ventricle walls. In in vitro experiments
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Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-02-17 Meihua Li,Can Zheng,Toru Kawada,Masashi Inagaki,Kazunori Uemura,Masaru Sugimachi
Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves the survival of rats with chronic heart failure (CHF). The mechanisms of cardioprotective effects of donepezil, however, remain totally unknown. To elucidate potential mechanisms, we examined whether central microinfusion of donepezil would exert cardioprotection. Intracerebroventricular microinfusion pumps
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Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-02-17 Shunsuke Kawai,Takuto Fujii,Takahiro Shimizu,Kenta Sukegawa,Isaya Hashimoto,Tomoyuki Okumura,Takuya Nagata,Hideki Sakai,Tsutomu Fujii
Pathophysiological functions of chloride intracellular channel protein 3 (CLIC3) in human gastric cancer have been unclear. In the tissue microarray analysis using 107 gastric cancer specimens, CLIC3 expression was negatively correlated with pathological tumor depth, and the patients with lower expression of CLIC3 exhibited poorer prognosis. CLIC3 was expressed in the plasma membrane of cancer cells
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Altered expression levels of autophagy-associated proteins during exercise preconditioning indicate the involvement of autophagy in cardioprotection against exercise-induced myocardial injury. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-02-17 Jian-Qi Yuan,Yang Yuan,Shan-Shan Pan,Ke Cai
Exercise has been reported to induce autophagy. We hypothesized that exercise preconditioning (EP)-related autophagy in cardiomyocytes could be attributed to intermittent ischemia-hypoxia, allowing the heart to be protected for subsequent high-intensity exercise (HE). We applied approaches, chromotrope-2R brilliant green (C-2R BG) staining and plasma cTnI levels measuring, to characterize two periods
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Comparative study of hyperpolarization-activated currents in pulmonary vein cardiomyocytes isolated from rat, guinea pig, and rabbit. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-02-11 Daichi Takagi,Yosuke Okamoto,Takayoshi Ohba,Hiroshi Yamamoto,Kyoichi Ono
Pulmonary vein (PV) cardiomyocytes have the potential to generate spontaneous activity, in contrast to working myocytes of atria. Different electrophysiological properties underlie the potential automaticity of PV cardiomyocytes, one being the hyperpolarization-activated inward current (Ih), which facilitates the slow diastolic depolarization. In the present study, we examined pharmacological characteristics
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Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-02-06 Joo Hyun Shin,Yu Fan,Do-Hee Kim,Han Byeol Jang,Suchan Chang,Yeonhee Ryu,Jong Han Bae,Sanghag Lee,Bong Hyo Lee,Scott C Steffensen,Chae Ha Yang,Hee Young Kim
While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mechanisms remain uncharacterized. We developed a combined mechano-electrical acupuncture device (MEA) and examined the effects of acupuncture at Neuro-Sps on systolic blood pressure (BP) in a rat
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Mechanism underlying the negative inotropic effect in rat left ventricle in hyperthermia: the role of TRPV1. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-02-05 Koji Obata,Hironobu Morita,Miyako Takaki
We have previously reported that the negative inotropic effects of hyperthermia (42 °C) on left ventricular (LV) mechanoenergetics using the excised, cross-circulated rat heart model. Here, we investigated the role of TRPV1 on LV mechanoenergetics in hyperthermia. We analyzed the LV end-systolic pressure-volume relation (ESPVR) and the linear relation between the myocardial oxygen consumption per beat
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Chronic administration of plasma from exercised rats to sedentary rats does not induce redox and metabolic adaptations. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-02-03 Georgios Goutianos,Nikos V Margaritelis,Theodora Sparopoulou,Aristidis S Veskoukis,Ioannis S Vrabas,Vassilis Paschalis,Michalis G Nikolaidis,Antonios Kyparos
The present study aimed to investigate whether endurance exercise-induced changes in blood plasma composition may lead to adaptations in erythrocytes, skeletal muscle and liver. Forty sedentary rats were randomly distributed into two groups: a group that was injected with pooled plasma from rats that swam until exhaustion and a group that was injected with the pooled plasma from resting rats (intravenous
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Increase in diastolic blood pressure induced by fragrance inhalation of grapefruit essential oil is positively correlated with muscle sympathetic nerve activity. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-01-30 Eriko Kawai,Ryosuke Takeda,Akemi Ota,Emiko Morita,Daiki Imai,Yuta Suzuki,Hisayo Yokoyama,Shin-Ya Ueda,Hidehiro Nakahara,Tadayoshi Miyamoto,Kazunobu Okazaki
Fragrance inhalation of essential oils is widely used in aromatherapy, and it is known to affect blood pressure (BP) and heart rate (HR) via autonomic control of circulation. In this study, we aimed to test the hypothesis that the changes in hemodynamics with fragrance inhalation were observed along with changes in muscle sympathetic nerve activity (MSNA). In study 1, thirteen healthy men were exposed
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Dynamic cerebral autoregulation in anterior and posterior cerebral circulation during cold pressor test. J. Physiol. Sci. (IF 2.955) Pub Date : 2020-01-29 Takuro Washio,Hironori Watanabe,Shigehiko Ogoh
We hypothesized that cerebral blood flow (CBF) regulation in the posterior circulation differs from that of the anterior circulation during a cold pressor test (CPT) and is accompanied by elevations in arterial blood pressure (ABP) and sympathetic nervous activity (SNA). To test this, dynamic cerebral autoregulation (dCA) in the middle and posterior cerebral arteries (MCA and PCA) were measured at
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Inaudible components of the human infant cry influence haemodynamic responses in the breast region of mothers. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-30 Hirokazu Doi,Simone Sulpizio,Gianluca Esposito,Masahiro Katou,Emi Nishina,Mayuko Iriguchi,Manabu Honda,Tsutomu Oohashi,Marc H Bornstein,Kazuyuki Shinohara
Distress vocalizations are fundamental for survival, and both sonic and ultrasonic components of such vocalizations are preserved phylogenetically among many mammals. On this basis, we hypothesized that ultrasonic inaudible components of the acoustic signal might play a heretofore hidden role in humans as well. By investigating the human distress vocalization (infant cry), here we show that, similar
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Endurance running exercise is an effective alternative to estradiol replacement for restoring hyperglycemia through TBC1D1/GLUT4 pathway in skeletal muscle of ovariectomized rats. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-28 Mizuho Kawakami,Naoko Yokota-Nakagi,Akira Takamata,Keiko Morimoto
Menopause is a risk factor for impaired glucose metabolism. Alternative treatment of estrogen for postmenopausal women is required. The present study was designed to investigate the effects of 5-week endurance running exercise (Ex) by treadmill on hyperglycemia and signal pathway components mediating glucose transport in ovariectomized (OVX) placebo-treated rats, compared with 4-week 17β-estradiol
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Potential role of hypothalamic microRNAs in regulation of FOS and FTO expression in response to hypoglycemia. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-14 Bashair M Mussa,Jalal Taneera,Abdul Khader Mohammed,Ankita Srivastava,Debasmita Mukhopadhyay,Nabil Sulaiman
Hypoglycemia-associated autonomic failure (HAAF) is a serious complication of diabetes which is associated with the absence of physiological homeostatic counter-regulatory mechanisms that are controlled by the hypothalamus and sympathetic nervous system. Identification of biomarkers for early detection of HAAF requires an advanced understanding of molecular signature of hypoglycemia which is yet to
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The local repolarization heterogeneity in the murine pulmonary veins myocardium contributes to the spatial distribution of the adrenergically induced ectopic foci. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-13 V M Potekhina,O A Averina,A A Razumov,V S Kuzmin,L V Rozenshtraukh
An atrial tachyarrhythmias is predominantly triggered by a proarrhythmic activity originate from the pulmonary veins (PV) myocardial sleeves; sympathetic or adrenergic stimulation facilitates PV proarrhythmia. In the present study the electrophysiological inhomogeneity, spatiotemporal characteristics of the adrenergically induced ectopic firing and sympathetic nerves distribution have been investigated
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Sex differences in baroreflex function in health and disease. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-12 Qi Fu,Shigehiko Ogoh
This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been demonstrated that healthy women have blunted cardiovagal baroreflx sensitivity during a rapid (i.e., within seconds) hypertensive stimulus, but baroreflex sensitivity is similar between the sexes during a hypotensive stimulus. Normal aging decreases cardiovagal
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Acupoint dependence of depressor and bradycardic responses elicited by manual acupuncture stimulation in humans. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-09 Hidehiro Nakahara,Toru Kawada,Shin-Ya Ueda,Eriko Kawai,Hiromi Yamamoto,Masaru Sugimachi,Tadayoshi Miyamoto
The cardiovascular effects of the autonomic nervous system (ANS) are modulated by inputs from peripheral sensors and other brain regions. However, it currently remains unknown whether the manual acupuncture (MA) stimulation of different acupuncture points evokes different responses by the heart and vasculature, a phenomenon known as "site specificity". Sixty healthy subjects were randomly divided into
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The effect of 5-HT1A receptor antagonist on reward-based decision-making. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-08 Fumika Akizawa,Takashi Mizuhiki,Tsuyoshi Setogawa,Mai Takafuji,Munetaka Shidara
When choosing the best action from several alternatives, we compare each value that depends on the balance between benefit and cost. Previous studies have shown that animals and humans with low brain serotonin (5-HT) level tend to choose smaller immediate reward. We used a decision-making schedule task to investigate whether 5-HT1A receptor is responsible for the decisions related to reward. In this
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Mild foot electrical stimulation is comparable with phenytoin in inhibiting pentylenetetrazol-induced kindling in rats. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-05 Arefe Ghasemi-Dehno,Abolfazl Jand,Monir Abasi-Moghadam,Mehdi Sadegh,Morteza Mousavi-Hasanzadeh,Mohammad Reza Palizvan
Increasing evidence demonstrates that electric stimulation has anticonvulsant effects. The present study was undertaken to investigate the effects of mild foot electrical stimulation (MFES) on the development of pentylenetetrazol (PTZ) kindling and compare its effectiveness with the more commonly used treatment, phenytoin. Kindling was induced in rats by repeated injections (every 24 h) of PTZ (37
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Cross talk between 26S proteasome and mitochondria in human mesenchymal stem cells' ability to survive under hypoxia stress. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-11-02 Ramada R Khasawneh,Ejlal Abu-El-Rub,Abdullah Omar Serhan,Bashar Omar Serhan,Hadeel Abu-El-Rub
Mesenchymal stem cells (MSCs) are regarded as unique cells which play an imperative role in the field of regenerative medicine. They are characterized by the self-renewal capacity, multi-lineage differentiation abilities and immunomodulation properties which render them perfectly ideal cell type for treating a wide range of chronic diseases. Despite these enchanted features, there are many hurdles
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Dopamine stimulation of the septum enhances exercise efficiency during complicated treadmill running in mice. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-10-29 Tetsuya Shiuchi,Takuya Masuda,Noriyuki Shimizu,Sachiko Chikahisa,Hiroyoshi Séi
We aimed to identify the neurotransmitters and brain regions involved in exercise efficiency in mice during continuous complicated exercises. Male C57BL/6J mice practiced treadmill running with intermittent obstacles on a treadmill for 8 days. Oxygen uptake (VO2) during treadmill running was measured as exercise efficiency. After obstacle exercise training, the VO2 measured during treadmill running
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Cardiac Na+/Ca2+ exchange stimulators among cardioprotective drugs. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-10-29 Yasuhide Watanabe
We previously reviewed our study of the pharmacological properties of cardiac Na+/Ca2+ exchange (NCX1) inhibitors among cardioprotective drugs, such as amiodarone, bepridil, dronedarone, cibenzoline, azimilide, aprindine, and benzyl-oxyphenyl derivatives (Watanabe et al. in J Pharmacol Sci 102:7-16, 2006). Since then we have continued our studies further and found that some cardioprotective drugs are
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The effects of moderate exercise and overtraining on learning and memory, hippocampal inflammatory cytokine levels, and brain oxidative stress markers in rats. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-10-22 Zahra Jahangiri,Zahra Gholamnezhad,Mahmoud Hosseini,Farimah Beheshti,Narges Kasraie
To investigate the exercise intensity effects on rats' memory and learning, animals were divided into control, moderate training (MT), and overtraining (OT) groups. At training last week, learning and memory was assessed using Morris water maze (MWM) and passive avoidance (PA) tests. Finally, the rat's brains were removed for evaluating oxidative stress and inflammatory cytokines. Overtraining impaired
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A phase II, open-label clinical trial on the combination therapy with medium-chain triglycerides and ghrelin in patients with chronic obstructive pulmonary disease. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-10-08 Keisuke Miki,Seigo Kitada,Mari Miki,Shu-Ping Hui,Rojeet Shrestha,Kenji Yoshimura,Kazuyuki Tsujino,Hiroyuki Kagawa,Yohei Oshitani,Hiroshi Kida,Ryoji Maekura,Kenji Kangawa
The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary disease (COPD). Eleven severe and very severe COPD patients received a 5-day treatment with edible MCT. Sequentially, 10 patients received a 3-week combination treatment with MCT and intravenous
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Firing properties of medullary expiratory neurons during fictive straining in cats. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-09-30 Sei-Ichi Sasaki,Ken Muramatsu,Masatoshi Niwa
Expiratory (E) neurons in the caudal nucleus retroambigualis extend descending spinal axons to the lumbar and sacral spinal cord. Discharge rates of single E neurons were recorded to examine differences in activity of E neurons projecting to the lumbar or sacral spinal cord during fictive straining induced by distention of the colon with a balloon. Firing frequencies of E neurons with descending axons
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Morphological, hormonal, and molecular changes in different maternal tissues during lactation and post-lactation. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-09-28 Gustavo Canul-Medina,Cristina Fernandez-Mejia
Milk supply and quality during lactation are critical for progeny survival. Maternal tissues and metabolism, influenced by hormonal changes, undergo modification during lactation to sustain breastfeeding. Two organs that suffer essential adjustment are the mammary glands and the bone; however, renal calcium conservation and calcium absorption from the intestine are also modified. Lactation leads to
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Tonic contraction develops in the colon during anaphylactic hypotension in anesthetized rats. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-09-21 Tao Zhang,Toshishige Shibamoto,Mamoru Tanida,Yuhichi Kuda,Wei Yang,Yasutaka Kurata
Diarrhea is a gastrointestinal symptom associated with systemic anaphylaxis and could be induced by increased colonic motility. We determined colonic motility and expulsion by measuring the intracolonic pressure (ICP) and expelled fluid weight in anesthetized rats during anaphylactic hypotension. Substantial systemic hypotension occurred in every sensitized rat after antigen injection. One min after
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Overexpression of calcitonin gene-related peptide protects mouse cerebral microvascular endothelial cells from high-glucose-induced damage via ERK/HIF-1/VEGF signaling. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-09-05 Yanjun Guo,Qin Zhang,Huilu Chen,Yixuan Jiang,Ping Gong
In the diabetic brain, hyperglycemia damages the cerebrovasculature and impairs neurovascular crosstalk. Calcitonin gene-related peptide (CGRP) is an important neuropeptide that is active in the vascular system. In this study, we aimed to investigate whether CGRP is involved in the high-glucose-induced damage in mouse cerebral microvascular endothelial (b.END3) cells and the possible mechanism in vitro
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TRPM8-mediated cutaneous stimulation modulates motor neuron activity during treadmill stepping in mice. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-09-03 Kotaro Tamura,Satoshi Sugita,Tadayuki Tokunaga,Yoshihiko Minegishi,Noriyasu Ota
Motor units are generally recruited from the smallest to the largest following the size principle, while cutaneous stimulation has the potential to affect spinal motor control. We aimed to examine the effects of stimulating transient receptor potential channel sub-family M8 (TRPM8) combined with exercise on the modulation of spinal motor neuron (MN) excitability. Mice were topically administrated 1
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Queueing arrival and release mechanism for K+ permeation through a potassium channel. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-08-27 Takashi Sumikama,Shigetoshi Oiki
The mechanism underlying ion permeation through potassium channels still remains controversial. K+ ions permeate across a narrow selectivity filter (SF) in a single file. Conventional scenarios assume that K+ ions are tightly bound in the SF, and, thus, they are displaced from their energy well by ion-ion repulsion with an incoming ion. This tight coupling between entering and exiting ions has been
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Cerebral blood flow regulation and cognitive function: a role of arterial baroreflex function. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-08-23 Shigehiko Ogoh,Takashi Tarumi
A strict adequate perfusion pressure via arterial baroreflex for the delivery of oxygen to the tissues of the body is well established; however, the importance of baroreflex for cerebral blood flow (CBF) is unclear. On the other hand, there is convincing evidence for arterial baroreflex function playing an important role in maintaining brain homeostasis, e.g., cerebral metabolism, cerebral hemodynamics
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Hypergravity-induced plastic alteration of the vestibulo-sympathetic reflex involves decrease in responsiveness of CAMK2-expressing neurons in the vestibular nuclear complex. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-08-21 Chikara Abe,Yusuke Yamaoka,Yui Maejima,Tomoe Mikami,Hironobu Morita
The vestibular system contributes to not only eye movement and posture but also the sympathetic response. Plastic alteration of the vestibulo-sympathetic reflex is induced by hypergravity load; however, the mechanism remains unknown. Here, we examined 2 g-induced changing in responsiveness of CAMK2-expressing neurons in the vestibular nucleus complex using optogenetic tools. The excitatory photostimulation
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Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-08-20 Vanshika Sinh,Youichirou Ootsuka
This study determined whether blockade of 5-hydroxytryptamine 2A (5-HT2A) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. For this purpose, male mice (C57BL/6N) were pre-instrumented with a telemetric probe to measure core body temperature and heart rate prior to experimentation. Vehicle or 5-HT2A antagonist, eplivanserin hemifumarate (SR-46349B) ((1Z,2
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Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-08-07 Shi-Qiang Wang,Dan Li,Yang Yuan
Exercise has an effect on the reduction of myocardial fibrosis in diabetic rats as previously reported, in which oxidative stress and the TGF-β1/Smad signaling pathway may play key roles. There is little direct experimental evidence that exercise alleviates myocardial fibrosis in type 2 diabetes mellitus (T2DM). Here we established a type 2 diabetic model by using streptozotocin and a high-fat diet
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Neuromuscular stimulation ameliorates ischemia-induced walking impairment in the rat claudication model. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-08-06 Momoko Shiragaki-Ogitani,Keita Kono,Futoshi Nara,Atsushi Aoyagi
Intermittent claudication (IC) is the most common symptom of peripheral arterial disease which significantly deteriorates the quality of life of patients. Exercise training is by far the most effective treatment for IC; however, the underlying mechanisms remain elusive. To determine the local mechanisms by which exercise training improves walking performance in claudicants, we developed an implantable
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Effect of regional muscle damage and inflammation following eccentric exercise on electrical resistance and the body composition assessment using bioimpedance spectroscopy. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-08-06 Keisuke Shiose,Yoko Tanabe,Takahiro Ohnishi,Hideyuki Takahashi
We investigated the effect of muscle damage and inflammation on electrical resistance and the body composition assessment by using bioimpedance spectroscopy (BIS). Twenty-two subjects completed 30 repetitions of maximal eccentric contractions of the elbow flexors with one arm. Whole-body resistance of extracellular and intracellular components (Re and Ri, respectively) on the exercised and non-exercised
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Mild hyperbaric oxygen and oxygenation under normobaric conditions: response to Dr. Andel's letter submitted to the editor. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-08-04 Akihiko Ishihara
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Augmented fear bradycardia in rats with heart failure. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-07-30 Satoshi Koba,Ichiro Hisatome,Tatsuo Watanabe
In congestive heart failure (CHF), while resting parasympathetic activity becomes reduced, parasympathetically-mediated responses to stressors have not been described. This study aimed to (1) elucidate the effect of CHF on fear bradycardia, a parasympathetically-mediated response, and (2) examine if brain oxidative stress of CHF mediates fear bradycardia. White noise sound (WNS) exposure to conscious
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Review of early development of near-infrared spectroscopy and recent advancement of studies on muscle oxygenation and oxidative metabolism. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-07-29 Takafumi Hamaoka,Kevin K McCully
Near-infrared spectroscopy (NIRS) has become an increasingly valuable tool to monitor tissue oxygenation (Toxy) in vivo. Observations of changes in the absorption of light with Toxy have been recognized as early as 1876, leading to a milestone NIRS paper by Jöbsis in 1977. Changes in the absorption and scatting of light in the 700-850-nm range has been successfully used to evaluate Toxy. The most practical
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Effects of testosterone on circadian rhythmicity in old mice. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-07-14 Atsuyoshi Hashimoto,Shingo Fujiki,Wataru Nakamura,Takahiro J Nakamura
Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels among others. To investigate whether testosterone replacement improves the age-related decline in circadian rhythmicity, we examined the effects of testosterone on the circadian rhythms of wheel
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Intermittent hyperbaric oxygen exposure mobilizing peroxiredoxin 6 to prevent oxygen toxicity. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-07-10 Lichao Zhang,Yanan Zhang,Zhongzhuang Wang,Yuliang Chen,Runping Li
Intermittent hyperbaric oxygen exposure (IE-HBO) can protect the body against oxygen toxicity, but the underlying mechanisms are not very clear. Peroxiredoxin 6 (Prdx6) is a special endogenous antioxidative protein. We explored if the protective effects of IE-HBO are related to Prdx6. Mice were exposed to 280 kPa O2 for 60 min, followed by 30-min exposure to 20% O2/N2 mixture with equal pressure, repeated
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Effects of astaxanthin supplementation and electrical stimulation on muscle atrophy and decreased oxidative capacity in soleus muscle during hindlimb unloading in rats. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-07-06 Miho Kanazashi,Masayuki Tanaka,Ryosuke Nakanishi,Noriaki Maeshige,Hidemi Fujino
The effects of a combination of the antioxidant astaxanthin (AX) and electrical stimulation (ES) on muscle mass and mitochondrial oxidative capacity were investigated in the soleus muscle of hindlimb unloaded rats. Five groups of male Sprague-Dawley rats were used; control, 1-week hindlimb unloading (HU), HU + AX, HU + ES, and HU + AX + ES. Respective rats in the AX groups received 50-mg/kg AX twice
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Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement. J. Physiol. Sci. (IF 2.955) Pub Date : 2019-07-04 Ken-Ichiro Hayashida,James C Eisenach,Masahito Kawatani,Thomas J Martin
Operant methods that allow animals to avoid painful stimuli are interpreted to assess the aversive quality of pain; however, such measurements require investigator-initiated stimuli to animals. Here we developed a shuttle maze test to repeatedly assess activity associated nociception without forced stimulation. Rats ambulate back and forth between two treat feeders by taking either a short route with
更新日期:2019-11-01