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Deciphering alternative splicing events and their therapeutic implications in colorectal Cancer Cell. Signal. (IF 4.8) Pub Date : 2024-03-12 Wenbo Ding, Qianni Xiao, Yanzhe Yue, Shuyu Chen, Xiangjian She, Bei Pan, Linpeng Zhou, Yujuan Yin, Youyue Li, Shukui Wang, Mu Xu
Colorectal cancer (CRC) is one of the most common malignant tumors with complex molecular regulatory mechanisms. Alternative splicing (AS), a fundamental regulatory process of gene expression, plays an important role in the occurrence and development of CRC. This study analyzed AS Percent Spliced In (PSI) values from 49 pairs of CRC and normal samples in the TCGA SpliceSeq database. Using Lasso and
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Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Wentao Hu, Menghan Wang, Guifang Sun, Limin Zhang, Hong Lu
Parkinson's disease (PD) is a gradually debilitating neurodegenerative syndrome. Here, we analyzed GSE7621 chip data obtained from the Gene Expression Omnibus (GEO) database to explore the pathogenesis of PD. Early B Cell Factor 3 (EBF3), a member of the highly evolutionarily conserved EBF-transcription factor family, is involved in neuronal development. EBF3 expression is low in the substantia nigra
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Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Yu Wang, Shuai Wang, Yuhao Wang, Chengcheng Wang, Yuhang Tang, Chao Zhang, Shiqiang Hou, Dong Yu, Ning Lin
Glucose is a fundamental substance for numerous cancers, including glioma. However, its influence on tumor cells regulatory mechanisms remains uncertain. SIRT1 is a regulator of deacetylation and a key player in the progression of malignant tumors. The objective of this study was to examine the role of glucose and SIRT1 in glioma. This study investigated the association of SIRT1 expression with clinicopathological
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microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Xin Chen, Yanhong Cao, Yining Guo, Jing Liu, Xiaohan Ye, Huan Li, Lu Zhang, Wenwei Feng, Shaoxiang Xian, Zhongqi Yang, Lingjun Wang, Ting Wang
Atherosclerosis is characterised by lipid accumulation and formation of foam cells in arterial walls. Dysregulated autophagy is a crucial factor in atherosclerosis development. The significance of microRNA (miR)-125b-1-3p in cardiovascular disease is well-established; however, its precise role in regulating autophagy and impact on atherosclerosis in vascular smooth muscle cells (VSMCs) remain unclear
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COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Yi Wang, Hai-Tao Li, Gang Liu, Chuan-Shen Jiang, Yan-Hong Ni, Jing-Hui Zeng, Xia Lin, Qing-Yun Wang, Da-Zhou Li, Wen Wang, Xiang-Peng Zeng
Pancreatic fibrosis is one of the most important pathological features of chronic pancreatitis (CP) and pancreatic stellate cells (PSCs) are the key cells of fibrosis. As an extracellular matrix (ECM) glycoprotein, cartilage oligomeric matrix protein (COMP) is critical for collagen assembly and ECM stability and recent studies showed that COMP exert promoting fibrosis effect in the skin, lungs and
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The polybasic region in Gαi proteins: Relevant or not? Insights from Gαi3 research Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Beata Rysiewicz, Ewa Błasiak, Marta Dziedzicka-Wasylewska, Agnieszka Polit
Heterotrimeric G proteins are responsible for signal transduction from G-protein-coupled receptors (GPCRs) to intracellular effectors. This process is only possible when G proteins are located on the inner side of the cell membrane due to the specific localization of GPCR receptors. The Gα subunit is directed to the cell membrane through several signals, including modification by fatty acid moieties
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HK2 promotes migration and invasion of intrahepatic cholangiocarcinoma via enhancing cancer stem-like cells' resistance to anoikis Cell. Signal. (IF 4.8) Pub Date : 2024-03-05 Xiaojing Du, Zhuoran Qi, Yunjia Jiao, Wenzhi Wu, Qingke Huang, Xuecheng Sun, Sunkuan Hu
Cancer stem-like cells (CSLCs) and anoikis resistance play crucial roles in the metastasis of cancers. However, it remains unclear whether CSLCs are related to anoikis resistance in intrahepatic cholangiocarcinoma (ICC). Here we identified a group of stemness-related anoikis genes (SRAGs) bioinformatic analysis of public data. Accordingly, a novel anoikis-related classification was established and
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BRD4 promotes LPS-induced endothelial cells senescence via activating and cooperating STING-IRF3 pathway Cell. Signal. (IF 4.8) Pub Date : 2024-03-04 Ruigong Zhu, Lei Zhang, Hao Zhang, Zhifeng Hu
Endothelial cells (ECs) senescence is closely associated with the initiation and development of multiple age-related cardiovascular diseases. It is necessary to explore the underlying molecular mechanisms of ECs senescence, which is not only the basis to decipher cellular senescence, but also a novel therapeutic target for the endothelial senescence-related diseases. BRD4, a key epigenetic regulator
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AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia Cell. Signal. (IF 4.8) Pub Date : 2024-03-01 Ke Liu, Zhaoyuan Zhang, Yu Xu, Yi Wu, Piaopiao Lian, Zhuoran Ma, Zhicheng Tang, Xiaoqian Zhang, Xiaoman Yang, Heng Zhai, Lei Zhang, Yan Xu, Xuebing Cao
Parkinson's disease patients on chronic levodopa often suffer from motor complications, which tend to reduce their quality of life. Levodopa-induced dyskinesia (LID) is one of the most prevalent motor complications, often characterized by abnormal involuntary movements, and the pathogenesis of LID is still unclear but recent studies have suggested the involvement of autophagy. The onset of LID was
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VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD Cell. Signal. (IF 4.8) Pub Date : 2024-02-28 Shubhashree Parimita, Amitava Das, Sanjoy Samanta
Vestigial-like family member 1 () is one of the X-linked genes whose expression is elevated in basal-like breast cancer (BLBC) because of X-chromosome isodisomy. As an approach towards understanding its function, we performed correlation study using transcript data of breast cancer patients from cBioPortal for Cancer Genomics. Our analysis identified EGFR as the most correlated transcript with VGLL1
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Adaptor protein HIP-55 promotes macrophage M1 polarization through promoting AP-1 complex activation Cell. Signal. (IF 4.8) Pub Date : 2024-02-27 Jingwei Bian, Yuzhong Zhu, Panhui Tian, Qiqi Yang, Zijian Li
Overwhelming macrophage M1 polarization induced by malfunction of the renin–angiotensin–aldosterone system (RAAS) initiates inflammatory responses, which play a crucial role in various cardiovascular diseases. However, the underlying regulatory mechanism remains elusive. Here, we identified adaptor protein HIP-55 as a critical regulator of macrophage M1 polarization. The expression of HIP-55 was upregulated
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mm9_circ_014683 regulates microglia polarization through canonical NFκB signaling pathway in diabetic retinopathy Cell. Signal. (IF 4.8) Pub Date : 2024-02-27 Tingting Chen, Congyao Wang, Wenhui Zhu, Fenfen Yu, Xia Dong, Yihua Su, Jingwen Huang, Lijun Huo, Pengxia Wan
Diabetic retinopathy (DR) is still the major cause of visual loss in working-aged people, one of the critical pathological processes are retinal microglia-mediated inflammation. Our previous study demonstrated that enhanced M1 microglial polarization was involved in retinal inflammation in DR, but the detailed mechanism needs further investigation. Circular RNAs (circRNAs) are important kind of noncoding
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Low shear stress induces macrophage infiltration and aggravates aneurysm wall inflammation via CCL7/CCR1/TAK1/ NF-κB axis Cell. Signal. (IF 4.8) Pub Date : 2024-02-27 Heng Wei, Guijun Wang, Qi Tian, Chengli Liu, Wenrui Han, Jianfeng Wang, Peibang He, Mingchang Li
This study aimed to elucidate the mechanism by which wall shear stress (WSS) influences vascular walls, accounting for the susceptibility of intracranial aneurysms (IAs) to rupture. We collected blood samples from the sacs of 24 ruptured and 28 unruptured IAs and analyzed the expression of chemokine CCL7 using enzyme-linked immunosorbent assay (ELISA). Univariate and multivariate logistic regression
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Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations Cell. Signal. (IF 4.8) Pub Date : 2024-02-27 Fei Li, Run Xiang, Yue Liu, Guoliang Hu, Quanbo Jiang, Tao Jia
Mitochondria, the cellular powerhouses, possess their own unique genetic system, including replication, transcription, and translation. Studying these processes is crucial for comprehending mitochondrial disorders, energy production, and their related diseases. Over the past decades, various approaches have been applied in detecting and quantifying mitochondrial genome variations with also the purpose
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Uptake pathways of cell-penetrating peptides in the context of drug delivery, gene therapy, and vaccine development Cell. Signal. (IF 4.8) Pub Date : 2024-02-24 Moataz Dowaidar
Cell-penetrating peptides have been extensively utilized for the purpose of facilitating the intracellular delivery of cargo that is impermeable to the cell membrane. The researchers have exhibited proficient delivery capabilities for oligonucleotides, thereby establishing cell-penetrating peptides as a potent instrument in the field of gene therapy. Furthermore, they have demonstrated a high level
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Identification of biomimetic nanoplatform-mediated delivery of si-ISG15 for treatment of triple-negative breast cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-23 Feiran Wang, Nannan Zhang, Ruishu Niu, Yunpeng Lu, Wei Zhang, Zhixian He
Triple-negative breast cancer (TNBC) is recognized as the most malicious form of breast cancer and exhibits an alarming tendency for recurrence, a heightened propensity for metastasis, and an overwhelmingly grim prognosis. Therefore, effective therapy approaches for TNBC are urgently required. In this study, the interferon-stimulated gene 15 (ISG15) expression level was analyzed by bioinformatics and
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Pan-cancer analysis reveals potential immunological and prognostic roles of COA6 in human cancers and preliminary exploration of COA6 in bladder cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-22 Hong Luo, Zhiyong Wang
Cytochrome C oxidase assembly factor 6 (COA6) is significantly involved in the progression of cancer and is aberrantly expressed in disease. Nevertheless, the comprehensive analysis of COA6 using many omics techniques, and its impact on the prognosis and immunological microenvironment of cancer patients, remains unexplored. We gathered data from 33 cancer cases and conducted a thorough analysis of
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Glial Cx43 hemichannels and neuronal Panx1 hemichannels and P2X7 receptors orchestrate presynaptic homeostatic plasticity Cell. Signal. (IF 4.8) Pub Date : 2024-02-22 Alberto Rafael, Marina Tizzoni, Cristian Justet, Andrea Cairus, Verónica Abudara, Nathalia Vitureira
The emerging role of glial cells in modulating neuronal excitability and synaptic strength is a growing field in neuroscience. In recent years, a pivotal role of gliotransmission in homeostatic presynaptic plasticity has been highlighted and glial-derived ATP arises as a key contributor. However, very little is known about the glial non-vesicular ATP-release pathway and how ATP participates in the
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LOC644656 promotes cisplatin resistance in cervical cancer by recruiting ZNF143 and activating the transcription of E6-AP Cell. Signal. (IF 4.8) Pub Date : 2024-02-21 Min Li, Jie Chen, Hong Zhang, Yi Zhang, Jiahui Wang, Zongji Shen, Youguo Chen, Wenjie Hou, Chi Chi
Cisplatin resistance remains a persistent challenge in cervical cancer (CC) treatment. Molecular biomarkers have garnered attention for their association with cisplatin resistance in various diseases. Long non-coding RNAs (lncRNAs) exert significant influence on CC development. This study explores the role of LOC644656 in regulating cisplatin resistance in CC. Parental and cisplatin-resistant CC cells
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CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-20 Shuang Li, Zihui Zhang, Zhifang Li, Lian Yang, Jianfeng Liu, Yujie Liu, Yancai Liu, Yanmei Hou, Mei Mei, Yuqin Huang
Glutamine addiction is a significant hallmark of metabolic reprogramming in tumors and is crucial to the progression of cancer. Nevertheless, the regulatory mechanisms of glutamine metabolism in endometrial cancer (EC) remains elusive. In this research, we found that elevated expression of CENPA and solute carrier family 38 member 1 (SLC38A1) were firmly associated with worse clinical stage and unfavorable
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LncRNA HOST2 promotes NSUN2-mediated breast cancer progression via interaction with ELAVL1 Cell. Signal. (IF 4.8) Pub Date : 2024-02-20 Xuehui Wang, Diya Liu, Kaiyao Hua, Lin Fang
Breast cancer (BC) is the most prevalent malignant tumor in women worldwide with high morbidity and mortality. NSUN2, a crucial RNA methyltransferase, plays a pivotal role in regulating the proliferation and metastasis of tumor cells. Our study demonstrated that NSUN2 is upregulated in BC tissues and cell lines, and its high expression is associated with a poor prognosis in BC patients. Knockout of
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Uptake of ox-LDL by binding to LRP6 mediates oxidative stress-induced BMSCs senescence promoting obesity-related bone loss Cell. Signal. (IF 4.8) Pub Date : 2024-02-20 Senxiong Meng, Zhuan Wang, Xiaonan Liu, Ke Shen, Yuan Gu, Bin Yu, Lei Wang
Obesity has long been thought to be a main cause of hyperlipidemia. As a systemic disease, the impact of obesity on organs, tissues and cells is almost entirely negative. However, the relationship between obesity and bone loss is highly controversial. On the one hand, obesity has long been thought to have a positive effect on bone due to increased mechanical loading on the skeleton, conducive to increasing
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Clinical value of molecular subtypes identification based on anoikis-related lncRNAs in castration-resistant prostate cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-17 Kailei Chen, Yunxuan Zhang, Chengyong Li, Yuenan Liu, Qi Cao, Xiaoping Zhang
Anoikis is a distinctive type of apoptosis. It is involved in tumor progression and metastasis. But its function in castration-resistant prostate cancer (CRPC) remains veiled. We aimed to develop a prognostic indicator based on anoikis-related long non-coding RNAs (arlncRNAs) and to investigate their biological function in CRPC. Differentially expressed anoikis-related genes were extracted from two
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Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis Cell. Signal. (IF 4.8) Pub Date : 2024-02-17 Xueqiang Tao, Fen Xue, Jiayuan Xu, Wenbo Wang
Intervertebral disc degeneration (IDD) is a main contributor to lower back pain, and compression stress-induced apoptosis of nucleus pulposus (NP) cells and extracellular matrix (ECM) degradation has been implicated in the IDD progression. The functions of platelet-rich plasma (PRP)-derived extracellular vesicles (PRP-EVs) in regulating these biological processes remain unclear in IDD. Here, we aimed
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Imaging of extracellular and intracellular ATP in pancreatic beta cells reveals correlation between glucose metabolism and purinergic signalling Cell. Signal. (IF 4.8) Pub Date : 2024-02-17 Seyed M. Ghiasi, Nynne M. Christensen, Per A. Pedersen, Emil Z. Skovhøj, Ivana Novak
Adenosine triphosphate (ATP) is a universal energy molecule and yet cells release it and extracellular ATP is an important signalling molecule between cells. Monitoring of ATP levels outside of cells is important for our understanding of physiological and pathophysiological processes in cells/tissues. Here, we focus on pancreatic beta cells (INS-1E) and test the hypothesis that there is an association
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Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/mTOR signaling Cell. Signal. (IF 4.8) Pub Date : 2024-02-16 Yu Xia, Yixin Tang, Zhixin Huang, Nantian Ke, Yue Zheng, Wanzhen Zhuang, Yi Zhang, Xiaoqing Yin, Mingshu Tu, Jianlin Chen, Yingshu Wang, Yi Huang
Esophageal squamous cell carcinoma (ESCC) is a severe malignancy with high incidence and mortality rate in China, while the application of standard chemotherapeutic drugs for ESCC meets the barriers of high toxicity and multiple drug resistance (MDR). In recent years, the anticancer effects of artesunate (ART), a Chinese medicine monomer have gained extensive attentions due to its characteristics of
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Pan-cancer analysis predicts CANT1 as a potential prognostic, immunologic biomarker Cell. Signal. (IF 4.8) Pub Date : 2024-02-16 Wei Yang, Zhidong Liu, Ting Liu
CANT1, calcium-activated nucleotidase 1, was reported to be upregulated in certain tumors. However, the function mechanism of CANT1 in pan-cancer is still unclear. We utilized the Cancer Genome Atlas Program (TCGA) and UALCAN databases to analyze CANT1 expression at the level of mRNA, protein, and promoter methylation in pan-cancer, and the cBioportal database to study the frequency of gene changes
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Deciphering disulfidptosis: Uncovering a lncRNA-based signature for prognostic assessment, personalized immunotherapy, and therapeutic agent selection in lung adenocarcinoma patients Cell. Signal. (IF 4.8) Pub Date : 2024-02-16 Chao Ma, Huan Zhao, Yang Sun, Weizheng Ding, Hui Wang, Yixin Li, Zhuoyu Gu
Disulfidptosis, a recently identified type of regulated cell death, plays critical roles in various biological processes of cancer; however, whether they can impact the prognosis of lung adenocarcinoma (LUAD) remains to be fully elucidated. We aimed to adopt this concept to develop and validate a lncRNA signature for LUAD prognostic prediction. For this study, the TCGA-LUAD dataset was used as the
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Insulin-stimulated translocation of the fatty acid transporter CD36 to the plasma membrane is mediated by the small GTPase Rac1 in adipocytes Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Man Piu Chan, Nobuyuki Takenaka, Yuki Abe, Takaya Satoh
Cluster of differentiation 36 (CD36) is a scavenger receptor (SR), recognizing diverse extracellular ligands in various types of mammalian cells. Long-chain fatty acids (FAs), which are important constituents of phospholipids and triglycerides, also utilize CD36 as a predominant membrane transporter, being incorporated from the circulation across the plasma membrane in several cell types, including
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Reactive oxygen species signalling in the deterioration of quality of mammalian oocytes cultured in vitro: Protective effect of antioxidants Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Ashutosh N. Pandey, Pramod K. Yadav, Karuppanan V Premkumar, Meenakshi Tiwari, Ajai K. Pandey, Shail K. Chaube
The fertilization (IVF) is the first choice of infertile couples worldwide to plan for conception. Besides having a significant advancement in IVF procedure, the success rate is still poor. Although several approaches have been tested to improve IVF protocol, minor changes in culture conditions, physical factors and/or drug treatment generate reactive oxygen species (ROS) in oocytes. Due to large size
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FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Jinlin He, Yiqing Zhao, Yiwen Zhang, Zhanqi Zhang, Di Li, Qiong Xu
Periodontitis is an oral inflammatory disease that causes alveolar bone destruction by activating osteoclast. FTO, a crucial demethylase of N6-methyladenosine(mA), exerts essential function in maintaining bone homeostasis. However, the effects of FTO on periodontitis-related bone destruction remain unknown. To investigate its role in inflammatory osteoclastogenesis, we overexpressed FTO in osteoclast
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Exosomal miR-122-3p represses the growth and metastasis of MCF-7/ADR cells by targeting GRK4-mediated activation of the Wnt/β-catenin pathway Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Binbin Song, Guoxin Hou, Maoyi Xu, Ming Chen
Breast cancer (BC) is a common cancer whose incidence continues to grow while its medical progress has stagnated. miRNAs are vital messengers that facilitate communications among different cancer cells. This study was to reveal the correlation of miR-122-3p expression with BC metastasis and Adriamycin (ADM) resistance and its mechanism of inhibiting BC metastasis. We found that expression of miR-122-3p
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Corrigendum to “Ripk3 regulates cardiac microvascular reperfusion injury: The role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action/filopodia based cellular migration” [Cell Signal. 45 (2018) 12–22] Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Hao Zhou, Jin Wang, Pingjun Zhu, Shunying Hu, Jun Ren
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Cross-regulation of cytoskeleton and calcium signaling at plant-pathogen interface Cell. Signal. (IF 4.8) Pub Date : 2024-02-13 Zunaira Afzal Naveed, Mahnoor Jamil, Nouman Asif, Muhammad Waqas, Sobia Ajaz, Sultan Habibullah Khan
During plant-pathogen interactions, cytoskeleton and calcium signaling work independently as well as in coordination with each other for developing preformed and induced defense responses. A cell wall (CW) – plasma membrane (PM) – cytoskeleton (CS) continuum is maintained by coordination of cytoskeleton and calcium signaling. The current review is focused on the current knowledge of cytoskeleton‑calcium
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Ceramides and mitochondrial homeostasis Cell. Signal. (IF 4.8) Pub Date : 2024-02-13 Song Ding, Guorui Li, Tinglv Fu, Tianyu Zhang, Xiao Lu, Ning Li, Qing Geng
Lipotoxicity arises from the accumulation of lipid intermediates in non-adipose tissue, precipitating cellular dysfunction and death. Ceramide, a toxic byproduct of excessive free fatty acids, has been widely recognized as a primary contributor to lipotoxicity, mediating various cellular processes such as apoptosis, differentiation, senescence, migration, and adhesion. As the hub of lipid metabolism
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Low-intensity pulsed ultrasound (LIPUS) promotes skeletal muscle regeneration by regulating PGC-1α/AMPK/GLUT4 pathways in satellite cells/myoblasts Cell. Signal. (IF 4.8) Pub Date : 2024-02-13 Huimin Duan, Shujie Chen, Xudong Mai, Liping Fu, Liujing Huang, Lanling Xiao, Miaomiao Liao, Hong Chen, Gang Liu, Liwei Xie
Low-Intensity Pulsed Ultrasound (LIPUS) holds therapeutic potential in promoting skeletal muscle regeneration, a biological process mediated by satellite cells and myoblasts. Despite their central roles in regeneration, the detailed mechanistic of LIPUS influence on satellite cells and myoblasts are not fully underexplored. In the current investigation, we administrated LIPUS treatment to injured skeletal
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Promoter A1312C mutation leads to microRNA-7 downregulation in human non-small cell lung cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-10 Shipeng Chen, Hui Wang, Mengmeng Guo, Xu Zhao, Jing Yang, Longqing Chen, Juanjuan Zhao, Chao Chen, Ya Zhou, Lin Xu
MicroRNA-7 (miRNA-7, miR-7) is a unique class of tumor suppressors, plays an important role in various physiological and pathological processes including human non-small cell lung cancer (NSCLC). In previous works, we revealed that miR-7 could regulate the growth and metastasis of human NSCLC cells. However, the mechanism of dysregulated miR-7 expression in NSCLC remains to be further elucidated. In
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IL-36 antagonism blunts the proliferation and migration of oral squamous cell carcinoma cells Cell. Signal. (IF 4.8) Pub Date : 2024-02-10 Zihui Li, Xiaoxin Zhang, Ke Li, Fuyan Li, Jiahao Kou, Yuhan Wang, Xiaoyue Wei, Yawei Sun, Yue Jing, Yuxian Song, QiuYa Yu, Haijia Yu, Shuai Wang, Shi Chen, Yangtin Wang, Simin Xie, Xiangyang Zhu, Yifan Zhan, Guowen Sun, Yanhong Ni
IL-36 is known to mediate inflammation and fibrosis. Nevertheless, IL-36 signalling axis has also been implicated in cancer, although understanding of exact contribution of IL-36 to cancer progression is very limited, partly due to existence of multiple IL-36 ligands with agonistic and antagonistic function. Here we explored the role of IL-36 in oral squamous cell carcinoma (OSCC). Firstly, we analyzed
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Hypoxia-inducible PRMT2 addiction in glioblastomas Cell. Signal. (IF 4.8) Pub Date : 2024-02-08 Feng Dong, Xiaoyu Sun, Jiacheng Su, Qian Li, You He, Wei Li, Baofeng Wang, Bo Wang, Guogang Xu, Xudong Wu
Hypoxia-inducible transcription factors (HIFs) are key transcription factors for cellular response to low oxygen levels. However, the specific mediators responsible for activating downstream transcription are not well characterized. We previously identified Protein Arginine methyltransferase 2 (PRMT2), a highly expressed methyltransferase in glioblastoma multiforme, as a transcription co-activator
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Circ-FOXO3 inhibits triple-negative breast cancer growth and metastasis via regulating WHSC1-H3K36me2-Zeb2 axis Cell. Signal. (IF 4.8) Pub Date : 2024-02-08 Danyang Chen, Shanshan Zeng, Huisi Qiu, Mingqiang Yang, Xin Lin, Xinwu Lv, Pan Li, Shaojuan Weng, Siyue Kou, Kai Luo, Zongcai Liu, Yanmei Yi, Hao Liu
Circular RNAs (circRNAs), a subclass of non-coding RNAs characterized by covalently closed continuous loops, play a key role in tumorigenesis and aggressiveness. However, the potential molecular mechanism of circRNAs in triple-negative breast cancer (TNBC) remains largely unknown. Exploring their roles and mechanisms in TNBC progression may help identify new diagnostic markers and therapeutic targets
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Multifaceted antineoplastic curative potency of novel water-soluble methylimidazole-based oxidovanadium (IV) complex against triple negative mammary carcinoma Cell. Signal. (IF 4.8) Pub Date : 2024-02-07 Noyel Ghosh, Samhita De, Nikhil Ranjan Pramanik, Parames C. Sil
A bunch of complexes harboring vanadium as metal centers have been reported to exhibit a wide array of antineoplastic properties that come under non‑platinum metallodrug series and emerge to offer alternative therapeutic strategies from the mechanistic behaviors of platinum-drugs. Though antineoplastic activities of vanado-complexes have been documented against several animal and xenografted human
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Single-cell RNA sequencing reveals the MIF-ACKR3 receptor-ligand interaction between iCAFs and tumor cells in esophageal squamous cell carcinoma Cell. Signal. (IF 4.8) Pub Date : 2024-02-07 Jialu Liang, Kai Lei, Ruihao Liang, Jing Huang, Binhua Tan, Huayue Lin, Minghui Wang
Esophageal squamous cell carcinoma (ESCC) is a malignant tumor of the gastrointestinal tract with a high morbidity and mortality rate. The heterogeneity of ESCC poses challenges in treatment and contributes to the poor prognosis of patients. Therefore, it is crucial to gain a better understanding of the tumor microenvironment (TME) heterogeneity and identify novel therapeutic targets. To solve this
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METTL3 modification of circStk4 affects mouse glomerular messangial cell autophagy, proliferation and apotosis by regulating miR-133a-3p/C1 axis Cell. Signal. (IF 4.8) Pub Date : 2024-02-06 Xiujuan Qin, Huiyu Chen, Wenjia Zheng, Xiaoli Zhu, Jiarong Gao
The study aimed to explore the impact of N6-methyladenosine (mA) modification in circStk4 on glomerular mesangial cells (GMCs) autophagy, proliferation and apoptosis. The interactions between circStk4 and miR-133a-3p, miR-133a-3p and C1 were demonstrated through luciferase reporter assays. The circStk4 localization was analyzed using fluorescence in situ hybridization and nuclear/cytosol fractionation
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SENP3 attenuates foam cell formation by deSUMOylating NLRP3 in macrophages stimulated with ox-LDL Cell. Signal. (IF 4.8) Pub Date : 2024-02-06 Jiaojiao Chen, Xuan Sun, Yuan Liu, Yuze Zhang, Min Zhao, Luyao Shao
SUMO-specific protease 3 (SENP3) participates in the removal of SUMOylation and maintains the balance of the SUMO system, which ensures normal functioning of substrates and cellular activities. In the present study, we found that SENP3 expression was significantly reduced in ox-LDL-stimulated macrophages. SENP3 overexpression suppressed and SENP3 knockdown promoted macrophage foam cell formation. Moreover
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The IGF2BP2-lncRNA TRPC7-AS1 axis promotes hepatocellular carcinoma cell proliferation and invasion Cell. Signal. (IF 4.8) Pub Date : 2024-02-04 Xu Zhang, Zilin Li, Huizong Nie, Yue Huang, Jingyang Du, Yiling Xi, Chaoqin Guo, Mingshan Mu, Xiangyu Li, Xiaoliang Zheng, Qiuran Xu, Dongsheng Huang, Linglan Tu, Liyan Cheng
Hepatocellular carcinoma(HCC) is one of the most common tumors in the world. Human insulin-like growth factor 2(IGF2) mRNA binding protein 2(IGF2BP2) plays an important role in the progression of hepatocellular carcinoma. Additionally, long non-coding RNA(lncRNA) has been confirmed as a key regulator of hepatocellular carcinoma occurrence. However, the function of TRPC7-AS1 has not been verified in
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Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF-κB signaling pathway Cell. Signal. (IF 4.8) Pub Date : 2024-02-04 Tiantian Shan, Xiaoying Li, Wenzhi Xie, Shaoqin Wang, Yan Gao, Yan Zheng, Guohai Su, Ying Li, Zhuo Zhao
Rap1 GTPase-activating protein (Rap1GAP) is an important tumor suppressor. The purpose of this study was to investigate the role of Rap1GAP in myocardial infarction (MI) and its potential mechanism. Left anterior descending coronary artery ligation was performed on cardiac-specific Rap1GAP conditional knockout (Rap1GAP-CKO) mice and control mice with MI. Seven days after MI, Rap1GAP expression in the
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TMEM16A inhibits renal tubulointerstitial fibrosis via Wnt/β-catenin signaling during hypertension nephropathy Cell. Signal. (IF 4.8) Pub Date : 2024-02-03 Feng Wang, Yiqing Zhang, Min Gao, Xuelin Zeng
Hypertensive nephropathy is the second leading cause of end-stage renal disease, but its underlying pathogenesis remains unclear. Therefore, this study aimed to explore whether transmembrane protein 16 A (TMEM16A), the molecular basis of calcium-activated chloride channels (CaCC), is involved in the development and progression of hypertensive nephropathy. In vivo and in vitro experiments were conducted
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FATP2 activates PI3K/Akt/mTOR pathway by inhibiting ATF3 and promotes the occurrence and development of bladder cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-03 Ming Jiang, Ru Chen, Bing Hu, Situ Xiong, Sheng Li, Bin Fu, Xiaoqiang Liu
Bladder cancer (BLCA) is ranked among the main causes of mortality in male cancer patients, and research into targeted therapies guided by its genomics and molecular biology has been a prominent focus in BLCA studies. Fatty acid transporter protein 2 (FATP2), a member of the FATPs family,is a key contributor to the progression of cancers such as hepatocellular carcinomas and melanomas.However,its role
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Machine learning combined with single-cell analysis reveals predictive capacity and immunotherapy response of T cell exhaustion-associated lncRNAs in uterine corpus endometrial carcinoma Cell. Signal. (IF 4.8) Pub Date : 2024-02-02 Feng Jiang, Ziyu Tao, Yun Zhang, Xiaoyan Xie, Yunlei Bao, Yifang Hu, Jingxin Ding, Chuyan Wu
The exhaustion of T-cells is a primary factor contributing to immune dysfunction in cancer. Long non-coding RNAs (lncRNAs) play a significant role in the advancement, survival, and treatment of Uterine Corpus Endometrial Carcinoma (UCEC). Nevertheless, there has been no investigation into the involvement of lncRNAs associated with T-cell exhaustion (TEXLs) in UCEC. The goal of this work is to establish
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Drp1-mediated mitochondrial fission promotes pulmonary fibrosis progression through the regulation of lipid metabolic reprogramming by ROS/HIF-1α Cell. Signal. (IF 4.8) Pub Date : 2024-02-02 Zhongkai Tong, Xuekui Du, Ying Zhou, Fangxue Jing, JiangPo Ma, Yingying Feng, Saiyun Lou, Qiong Wang, Zhaoxing Dong
To confirm the mechanism of dynamic-related protein 1 (Drp1)-mediated mitochondrial fission through ROS/HIF-1α-mediated regulation of lipid metabolic reprogramming in the progression of pulmonary fibrosis (PF). A mouse model of PF was established by intratracheal instillation of bleomycin (BLM) (2.5 mg/kg). A PF cell model was constructed by stimulating MRC-5 cells with TGF-β (10 ng/mL). Pathological
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Cuproptosis-associated genes (CAGs) contribute to the prognosis prediction and potential therapeutic targets in hepatocellular carcinoma Cell. Signal. (IF 4.8) Pub Date : 2024-02-01 Xiaoli Shi, Dongmin Shi, Yefeng Yin, Yuxiao Wu, Wenwei Chen, Yue Yu, Xuehao Wang
Cuproptosis is a novel form of cell death that exhibits close association with mitochondrial respiration and occurs through distinct mechanisms compared to previously characterized forms of cell death. However, the precise impact of cuproptosis-associated genes (CAGs) on prognosis, immune profiles, and treatment efficacy in hepatocellular carcinomas (HCC) remains poorly understood. A comprehensive
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USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy Cell. Signal. (IF 4.8) Pub Date : 2024-02-01 Dongchen Wang, Zihao Jiang, Junyan Kan, Xiaomin Jiang, Chang Pan, Shijie You, Ruirui Chang, Juan Zhang, Hongfeng Yang, Linlin Zhu, Yue Gu
Doxorubicin (Dox) is a potent antineoplastic agent, but its use is curtailed by severe cardiotoxicity, known as Dox-induced cardiomyopathy (DIC). The molecular mechanism underlying this cardiotoxicity remains unclear. Our current study investigates the role of Ubiquitin-Specific Protease 36 (USP36), a nucleolar deubiquitinating enzyme (DUB), in the progression of DIC and its mechanism. We found increased
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Crosstalk between m6A modification and non-coding RNAs in HCC Cell. Signal. (IF 4.8) Pub Date : 2024-02-01 Zitong Qiu, Xingxing Yuan, Xinyue Wang, Songjiang Liu
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide, with high morbidity and occurrence. Although various therapeutic approaches have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of HCC remain enigmatic. The N6-methyladenosine (m6A) RNA modification is believed to regulate RNA metabolism and further gene expression
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Targeting inhibition of TCTP could inhibit proliferation and induce apoptosis in AML cells Cell. Signal. (IF 4.8) Pub Date : 2024-02-01 Di Xia, Gui-Ping Xu, Ying-Ting Zhang, Wei-Wei Yan, Xiao-Rong Pan, Jian-Hua Tong
Translationally controlled tumor protein (TCTP) is a highly conserved multifunctional protein, which participates in many important physiological processes. Recently, the roles of TCTP in cell proliferation and apoptosis, especially its close relationship with various tumors, have attracted widespread attention. In this study, we found that the protein level of TCTP was significantly reduced in acute
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Immortalised chronic myeloid leukemia (CML) derived mesenchymal stromal cells (MSCs) line retains the immunomodulatory and chemoprotective properties of CML patient-derived MSCs Cell. Signal. (IF 4.8) Pub Date : 2024-01-27 Esther Sathya Bama Benjamin, Elizabeth Vinod, Raveen Stephen Stallon Illangeswaran, Bharathi M. Rajamani, Rakhi Thalayattu Vidhyadharan, Abhirup Bagchi, Arnab Maity, Ajith Mohan, Ganesh Parasuraman, Soosai Manickam Amirtham, Aby Abraham, Shaji R Velayudhan, Poonkuzhali Balasubramanian
Despite the success of Tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML), leukemic stem cells (LSCs) persist, contributing to relapse and resistance. CML Mesenchymal Stromal Cells (MSCs) help in LSC maintenance and protection from TKIs. However, the limited passage and self-differentiation abilities of primary CML MSCs hinder extensive research. To overcome this, we generated
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Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation–related genes analysis and identify potential therapeutic target ARFIP2 Cell. Signal. (IF 4.8) Pub Date : 2024-01-30 Fenfen Jiang, Yan Xu, Zhuang Jiang, Bin Hu, Qing Lv, Zhiyong Wang
Hepatocellular carcinoma is one of the most common malignancies, and its prognosis and treatment outcome cannot be accurately predicted. ADP-ribosylation (ADPR) is a post-translationa modification of proteins involved in protein trafficking and immune response. Therefore, it is necessary to explore the ADPR-related genes associated with the prognosis and therapeutic efficacy of hepatocellular carcinoma
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The transmembrane protein TMEM97 and the epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression Cell. Signal. (IF 4.8) Pub Date : 2024-01-28 Jing Li, Hongtao Shen, Lian-Wang Guo
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Multi-omics reveals the switch role of abnormal methylation in the regulation of decidual macrophages function in recurrent spontaneous abortion Cell. Signal. (IF 4.8) Pub Date : 2024-01-29 Qian Li, Lei Zhang, Hua Zou, Tingjia Chai, Yan Su, Yan Shen, Xiao He, Hongbo Qi, Chunli Li
RSA, recurrent spontaneous abortion, often causes serious physical damage and psychological pressure in reproductive women with unclarified pathogenesis. Abnormal function of decidual cells and aberrant DNA methylation have been reported to cause RSA, but their association remains unclear. Here, we integrated transcriptome, DNA methylome, and scRNA-seq to clarify the regulatory relationship between
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SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its silencing aggravates diabetic retinopathy of db/db mice: Activation of NLRP3/NF-κB pathway Cell. Signal. (IF 4.8) Pub Date : 2024-01-23 Yun Zhou, Song Yue, Lihua Li, Jiahua Zhang, Lei Chen, Jun Chen
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Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis Cell. Signal. (IF 4.8) Pub Date : 2024-01-27 Yangmei Gong, Guifang Luo, Shufen Zhang, Yijing Chen, Yi Hu
Cervical cancer is the most common malignant tumor in the female reproductive system worldwide, and its molecular mechanisms remain complex and poorly understood. Various techniques, including transcriptome sequencing, RT-qPCR, ELISA, immunofluorescence, Western blot, CCK-8 assay, Transwell assay, and xenograft models, were employed to investigate gene/miRNA expression, cellular proliferation, migration