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Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis Immunobiology (IF 2.8) Pub Date : 2024-03-06 Dan Gu, Ting Cao, Shijie Yi, Xiaoqian Li, Ya Liu
We have previously found that enhancer of zeste homolog 2 (EZH2) is correlated with inflammatory infiltration and mucosal cell injury in ulcerative colitis (UC). This study aims to analyze the role of X-inactive specific transcript (XIST), a possible interactive long non-coding RNA of EZH2, in UC and to explore the mechanisms. C57BL/6N mice were treated with dextran sulfate sodium (DSS), and mouse
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The predictive value of miR-377 and phospholipase A2 in the early diagnosis of diabetic kidney disease and their relationship with inflammatory factors Immunobiology (IF 2.8) Pub Date : 2024-02-15 Chenhao Xing, Lijing Huo, Hongyue Tang, Yamin Lu, Guangxia Liu, Fang Chen, Zhan Hou
The value of novel biomarkers for DKD has received increasing attention, and there is an urgent need for novel biomarkers with sensitivity, specificity and ability to detect kidney damage.miR-377 regulates many basic biological processes, plays a key role in tumor cell proliferation, migration and inflammation, and can also increase the expression of matrix proteins and fibronectin, leading to renal
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Identification and validation of potential biomarkers related to oxidative stress in idiopathic pulmonary fibrosis Immunobiology (IF 2.8) Pub Date : 2024-02-14 Xianglin Du, Zhen Ma, Yanqing Xing, Liting Feng, Yupeng Li, Chuanchuan Dong, Xinkai Ma, Rujie Huo, Xinrui Tian
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial pneumonia with a poor prognosis and a pathogenesis that has not been fully elucidated. Oxidative stress is closely associated with IPF. In this research, we aimed to identify reliable diagnostic biomarkers associated with the oxidative stress through bioinformatics techniques. The gene expression profile data from
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Transmission patterns of C1-INH deficiency hereditary angioedema favors a wild-type male offspring: Our experience at Chandigarh, India Immunobiology (IF 2.8) Pub Date : 2024-02-06 Sanghamitra Machhua, Ankur Kumar Jindal, Suprit Basu, Isheeta Jangra, Prabal Barman, Rahul Tyagi, Archan Sil, Reva Tyagi, Anit Kaur, Sanchi Chawla, Sendhil M. Kumaran, Sunil Dogra, Manpreet Dhaliwal, Saniya Sharma, Amit Rawat, Surjit Singh
Deficiency of C1-inhibitor (C1-INH) protein, caused by pathogenic variants in the Serpin family G member 1 () gene, is the commonest pathophysiological abnormality (in ∼95 % cases) in patients with hereditary angioedema (HAE). C1-INH protein provides negative control over kallikrein–kinin system (KKS). Although the inheritance of the HAE-C1-INH is autosomal dominant, female predominance has often been
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Evaluation of the serum levels of CCL2, CCL3, and IL-29 after first and second administrations of the COVID-19 vaccine (Oxford–AstraZeneca) Immunobiology (IF 2.8) Pub Date : 2024-01-28 Zahra Bagheri-Hosseinabadi, Ayat Kaeidi, Mahdi Rezvani, Gholamhossein Taghipour Khaje Sharifi, Mitra Abbasifard
Background Previous studies show that chemokines and cytokines play a very important role in eliciting an appropriate response against viruses. Vaccination causes inflammation in the person receiving the vaccine, accompanied with production of inflammatory molecules by immune cells. The more and better the production and expression of chemokines and cytokines by immune cells, the better the response
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The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion Immunobiology (IF 2.8) Pub Date : 2024-01-28 Wanlu Su, Yaqi Yin, Yu Cheng, Songyan Yu, Ruofan Hu, Haixia Zhang, Jia Hu, Rui Ren, Yue Zhang, Jian Zhao, Anning Wang, Zhaohui Lyu, Yiming Mu, Jieqing Gao
Background Infusion of mesenchymal stem cells (MSCs) induces polarization of M2 macrophages in adipose tissue of type 2 diabetes (T2D) mice. Studies have shown that M2 macrophages were divided into four sub-phenotypes (M2a, M2b, M2c and M2d) with different functions, and manuscripts have also confirmed that macrophages co-cultured with MSCs were not matched with known four phenotype macrophages. Therefore
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Hyperglycemia modulates M1/M2 macrophage polarization in chronic diabetic patients with pulmonary tuberculosis infection Immunobiology (IF 2.8) Pub Date : 2024-01-14 Sudhasini Panda, Alisha Arora, Kalpana Luthra, Anant Mohan, Naval K Vikram, Neeraj Kumar Gupta, Archana Singh
Increased susceptibility to bacterial infections like tuberculosis (TB) is one of the complications of type 2 diabetes, however the underlying mechanisms remains poorly characterized. To explore how chronic hyperglycemia in diabetes affects progression of active TB, we examined mRNA expression of M1 (proinflammatory) and M2 (anti-inflammatory) cytokines/markers, in monocyte-derived macrophages obtained
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Clinical relevance of ORCs in predicting prognosis and immunotherapy outcomes: A pan-cancer analysis Immunobiology (IF 2.8) Pub Date : 2024-01-10 Yajun Zhao, Jiangtao Wang, Xiaodong Liang, Chen Wang
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Toll-like receptor expression and functional behavior in platelets from patients with systemic lupus erythematosus Immunobiology (IF 2.8) Pub Date : 2023-12-28 María C. Baroni Pietto, Ana C. Glembotsky, Paola R. Lev, Cecilia R. Marín Oyarzún, Geraldine De Luca, Graciela Gomez, María V. Collado, Nancy Charó, Adela S. Cellucci, Paula G. Heller, Nora P. Goette, Rosana F. Marta
Background Multiple blood cell abnormalities participate in the development of inflammation in systemic lupus erythematosus (SLE). Although platelets have been suggested as one of these contributors through the release of their content during activation, there are limited specific data about their role as immune players in SLE. Materials and Methods Thirteen SLE patients were included. Flow cytometry
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Engagement of CD300c by a novel monoclonal antibody induces the differentiation of monocytes to M1 macrophages Immunobiology (IF 2.8) Pub Date : 2023-12-21 Su In Lee, Haneul Kim, Chang Ki Lim, Jae Dong Kim, Jeong Seok Heo, Joongoo Jung, Chan Kim, Hong Jae Chon, Jae-Won Jeon
Human CD300c is expressed on various immune or cancer cells and is a novel B7 family member, functioning as an activity modulator on immune cells. To elucidate the function of CD300c, we developed CL7, a human CD300c-specific monoclonal antibody, and assessed its biological activity. The specific binding of CL7 monoclonal antibody against recombinant CD300c antigen was confirmed using enzyme-linked
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Significance of m6A in subtype identification, immunological evolution, and therapeutic sensitivity of RA Immunobiology (IF 2.8) Pub Date : 2023-12-21 Chenxi Ma, Jiasheng Wu, Hongwei Lei, He Huang, Yingnan Li
N6-methyladenosine (m6A) is one kind of important epigenetic modification pattern which is extensively involved in immune regulation. The development and progression of autoimmune diseases are closely related to immune dysregulation. Considering that rheumatoid arthritis (RA) is a typical autoimmune disease, the m6A process might be one of the important regulatory mechanisms in the pathogenesis of
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Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen Immunobiology (IF 2.8) Pub Date : 2023-12-21 Chengyue Zhou, Dan Han, Hui Fang, Dake Huang, Heping Cai, Yujun Shen, Yuxian Shen, Jun Liu
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) stress-induced protein, and it has been reported that ER stress and unfolded protein response (UPR) are closely related to the immune system. The spleen is an important immune organ and we have shown in our previous research that MANF is expressed in human spleen tissues. However, there have been limited studies
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Chlorella vulgaris extract and Imiquimod as new therapeutic targets for leishmaniasis: An immunological approach Immunobiology (IF 2.8) Pub Date : 2023-12-14 Maria Gabriella Nunes de Melo, Isabelle Barreto da Silva Moreira Reino, Victor Vaitkevicius-Antão, Jady Moreira da Silva, José Noé da Silva Júnior, Alexsandra Frazão de Andrade, Raquel Pedrosa Bezerra, Daniela de Araújo Viana Marques, Silvana de Fátima Ferreira da Silva, Paulo Sérgio Ramos de Araújo, Virginia Maria Barros de Lorena, Rayana Carla Silva de Morais, Milena de Paiva-Cavalcanti
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ADAR1 regulates macrophage polarization and is protective against liver ischemia and reperfusion injury Immunobiology (IF 2.8) Pub Date : 2023-12-14 Linxiao Wang, Chujun Duan, Xiuhua Wu, Jiangang Xie, Xiaojun Zhao, Yi Si, Dan Wu, Yifan Wang, Peng Zhao, Jijun Chen, Wen Yin, Junjie Li
Liver ischemia and reperfusion injury (LIRI) is a major risk for the poor prognosis of patients receiving liver transplantation. The molecular mechanism involved in LIRI is complex and related to various cellular components. We previously reported that adenosine deaminase acting on RNA 1 (ADAR1) alleviated the allogeneic skin graft rejection by regulating macrophage polarization. However, the regulatory
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Up-Regulation of scleral C5b-9 and Its regulation of the NLRP3 Inflammasome in a Form-Deprivation Myopia Mouse Model Immunobiology (IF 2.8) Pub Date : 2023-12-12 Kang Xiao, Zhengyu Chen, Songqing He, Qin Long
Background Myopia has become a major public health problem worldwide. Although the involvement of the complement system in myopia progression has been reported, the underlying mechanism has not been well established. In this study, we induced a form deprivation (FD) myopia mouse model to investigate the mechanisms. Methods Both C6-knockout (KO) and wild-type (WT) mice were divided into FD and normal
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Vitexin along with verapamil downregulates efflux pump P-glycoprotein in macrophages and potentiate M1 to M2 switching via TLR4-NF-κB-TNFR2 pathway in lipopolysaccharide treated mice Immunobiology (IF 2.8) Pub Date : 2023-12-06 Ayantika Kundu, Pratiti Ghosh, Biswadev Bishayi
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Adipose tissue-derived mesenchymal stromal cells attenuate acute lung injury induced by trauma and haemorrhagic shock Immunobiology (IF 2.8) Pub Date : 2023-11-25 Zhi Zhang, Xiaoxia Yang, Qinghong Meng, Yiyin Long, Xiaofeng Shi, Yuliang Wang
Background Mesenchymal stromal cells (MSCs) have shown promising therapeutic options for acute lung injury (ALI) caused by multiple factors. Here, we evaluated the therapeutic potential of adipose tissue-derived mesenchymal stromal cells (ADSCs) in trauma and hemorrhagic shock (THS)-induced ALI. Methods ALI model induced by THS was constructed by fractures plus abdominal trauma plus acute hemorrhage
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Single-cell transcriptional gene signature analysis identifies IL-17 signaling pathway as the key pathway in sepsis Immunobiology (IF 2.8) Pub Date : 2023-11-24 Huayan Zhao, Yuanzhe Li, Guiying Sun, Ming Cheng, Xianfei Ding, Kun Wang
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Identification and validation of basic fibroblast growth factor as a prognostic biomarker for the response of lung adenocarcinoma patients to bevacizumab treatment Immunobiology (IF 2.8) Pub Date : 2023-11-24 Hongtao Jiang, Ce Li, Qiang Gong, Hailing Qie
Basic fibroblast growth factor (bFGF) stimulates angiogenesis, influencing the proliferation, migration, and survival of tumour cells, which have pivotal roles in tumour progression. This study investigated the prognostic significance of bFGF expression in lung adenocarcinoma treated with bevacizumab. The expression levels of bFGF were assessed in bevacizumab-treated patients with lung adenocarcinoma
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Alteration of PBMC transcriptome profile after interaction with multipotent mesenchymal stromal cells under “physiological” hypoxia Immunobiology (IF 2.8) Pub Date : 2023-11-23 A.N. Gornostaeva, P.I. Bobyleva, E.R. Andreeva, B.Sh. Gogiya, L.B. Buravkova
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Impact of gold nanoparticles (AuNPs) on eosinophils isolated from male and female individuals Immunobiology (IF 2.8) Pub Date : 2023-11-21 Marion Vanharen, Denis Girard
It is well established that some differences exist between the male and female immune systems. Despites this, a sex-based analysis is not frequently performed in most scientific published reports. Knowing that inflammation is a common undesired effect observed resulting from nanoparticle (NP) exposure, we investigate here how in vitro treatment of gold NPs with a primary size of 20 and 70 nm (AuNP20
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Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer’s disease Immunobiology (IF 2.8) Pub Date : 2023-11-17 Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Yan
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Human macrophage immunometabolism regulator (MACIR) in patients with periodontitis Immunobiology (IF 2.8) Pub Date : 2023-11-07 Karol Serwin, Małgorzata Kozak, Małgorzata Mazurek-Mochol, Katarzyna Piotrowska, Michał Czerewaty, Andrzej Pawlik
Objective Periodontitis is a local inflammatory reaction caused by bacterial infection in which immune cells, including macrophages, are involved. Recent studies have shown that an important regulator of macrophage function is the human macrophage immunometabolism regulator (MACIR). This gene has been shown to play a key role in modulating the immune response by affecting the activity of fibroblasts
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The signature and predictive value of immune parameters in patients with secondary hemophagocytic lymphohistiocytosis Immunobiology (IF 2.8) Pub Date : 2023-11-02 Huan Bai, Yun Wang, Ling Shen, Ying Luo, Guoxing Tang, Feng Wang, Ziyong Sun, Hongyan Hou
Background Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare but fatal clinical syndrome, characterized by severe immune dysfunction and overwhelming inflammatory response. However, the host immune signature and also its role in predicting the clinical outcome are not fully described. Objective The present study aims to investigate the host immune status of sHLH patients in the early stage
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Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome Immunobiology (IF 2.8) Pub Date : 2023-11-02 Hui-Jin Cho, Dong Joon Lee, Young-Su Yi
Calmodulin (CaM)-lysine N-methyltransferase (CAMKMT) is a novel methyltransferase that catalyzes lysine trimethylation in CaM. However, its specific roles in inflammatory responses and diseases remain unclear. In this study, we investigated the effects of CAMKMT on caspase-11 non-canonical inflammasomes. CAMKMT expression levels were significantly decreased during inflammatory responses activated by
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IL-27p28 specifically regulates MHC II expression in macrophages through CIITA Immunobiology (IF 2.8) Pub Date : 2023-11-01 Yu Han, Xu Zhang, Qing Wang, Xiaoyue Cui, Hesuiyuan Wang, Xiang Zhang, Qian Wang, Jianbin Ji, Yuebing Wang, Shusen Wang, Xiuming Zhang, Haijin Xu, Mingqiang Qiao, Zhenzhou Wu
Antigen-presenting cells (APCs) constantly express major histocompatibility complex II (MHC II), including macrophages and dendritic cells (DCs) which deliver antigens to CD4+ T cells and play an important role in adaptive immunity. The expression of MHC II is controlled by the transcriptional coactivator CIITA. Interleukin-27 (IL-27), a newly discovered IL-12 family cytokine, is composed of p28 and
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Comparable cytokine release ex-vivo by whole blood from COVID-19 patients with and without non-invasive ventilation Immunobiology (IF 2.8) Pub Date : 2023-10-24 Martina Bonacini, Ilaria Ferrigno, Alessandro Rossi, Nicola Facciolongo, Marco Massari, Romina Corsini, Veronica Galli, Alessandro Zerbini, Carlo Salvarani, Stefania Croci
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Tumor-infiltrating lymphocytes, PD-L1, and MMR-deficiency combined characterization may identify subgroups of rectal cancer patients who would benefit from immunotherapy Immunobiology (IF 2.8) Pub Date : 2023-10-18 Alexandra Giatromanolaki, Christos Kavazis, Anastasia G. Gkegka, Maria Kouroupi, Alexandra Tsaroucha, Michael Pitiakoudis, Michael I. Koukourakis
Introduction Mismatch repair deficiency, immunological fertility, and PD-L1 expression status are key histopathological and molecular features defining tumor responsiveness to immunotherapy and, eventually, prognosis. These were investigated in a series of locally advanced rectal cancer patients treated with postoperative chemotherapy and radiotherapy. Materials and methods Tumor-infiltrating lymphocyte
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The role of T cells and shared genes in psoriasis and inflammatory bowel disease based on single-cell RNA and comprehensive analysis Immunobiology (IF 2.8) Pub Date : 2023-10-04 Xiaofeng Liang, Zhishen Peng, Ying Deng, Xiaobing Lin, Runnan Chen, Yujing Niu, Weiyi Lin, Zien Lin, Kuan Lai, Shanshan Wei
Psoriasis and inflammatory bowel disease (IBD) have a similar etiology, including abnormal activation of T cells. Differentially expressed genes (DEGs) analysis was used to search for shared genes. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis were then performed. Secondly, single-cell RNA analysis (scRNA-seq) and immune infiltration were employed to explore the immune
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Evaluation of the anti-inflammatory effects of PI3Kδ/γ inhibitors for treating acute lung injury Immunobiology (IF 2.8) Pub Date : 2023-10-05 Wendian Xiong, Lei Jia, Yanfei Cai, Yun Chen, Mingzhu Gao, Jian Jin, Jingyu Zhu
Phosphatidylinositol 3-kinase delta (PI3Kδ) and gamma (PI3Kγ) are predominantly located in immune and hematopoietic cells. It is well-established that PI3Kδ/γ plays important roles in the immune system and participates in inflammation; hence, it could be a potential target for anti-inflammatory therapy. Currently, several PI3K inhibitors are used clinically to treat cancers with aberrant PI3K signaling;
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Study of tissue transglutaminase spliced variants expressed in THP-1 derived macrophages exhibiting distinct functional phenotypes Immunobiology (IF 2.8) Pub Date : 2023-10-02 Paula Arbildi, Federico Calvo, Victoria Macías, Claudio Rodríguez-Camejo, Cecilia Sóñora, Ana Hernández
Tissue transglutaminase (TG2) expressed in monocytes and macrophage is known to participate in processes during either early and resolution stages of inflammation. The alternative splicing of tissue transglutaminase gene is a mechanism that increases its functional diversity. Four spliced variants are known with truncated C-terminal domains (TGM2_v2, TGM2_v3, TGM2_v4a, TGM2_v4b) but scarce information
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Identification of hub biomarkers and immune-related pathways participating in the progression of Kawasaki disease by integrated bioinformatics analysis Immunobiology (IF 2.8) Pub Date : 2023-09-26 Yang Gao, Xuan Tang, Guanghui Qian, Hongbiao Huang, Nana Wang, Yan Wang, Wenyu Zhuo, Jiaqi Jiang, Yiming Zheng, Wenjie Li, Zhiheng Liu, Xuan Li, Lei Xu, Jiaying Zhang, Li Huang, Ying Liu, Haitao Lv
Background Kawasaki disease (KD) is a systemic vasculitis that commonly affects children and its etiology remains unknown. Growing evidence suggests that immune-mediated inflammation and immune cells in the peripheral blood play crucial roles in the pathophysiology of KD. The objective of this research was to find important biomarkers and immune-related mechanisms implicated in KD, along with their
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PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis Immunobiology (IF 2.8) Pub Date : 2023-09-19 Tingting Zhou, Xinqi Wang, Jiangping Kong, Lingxiang Yu, Huimin Xie, Feier Wang, Shenqian Xu, Zongwen Shuai, Qiang Zhou, Faming Pan
Background Ankylosing spondylitis (AS) is a common inflammatory arthritis without a reliable biomarker. The role of methylation and mRNA expression of PRICKLE1 promoter in the pathogenesis of ankylosing spondylitis remains unclear. Methods A two-stage case-control design was used to detect the characteristics of methyl group and transcriptome of PRICKLE1 gene in Ankylosing spondylitis. The methylation
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Identification and validation of a novel NK cells-related signature to predict prognosis and immune microenvironment in LUAD Immunobiology (IF 2.8) Pub Date : 2023-09-23 Chenghu Song, Weici Liu, Guanyu Jiang, Zhao He, Ruixin Wang, Xiaokun Wang, Ruo Chen, Wenjun Mao, Shaojin Zhu
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Alterations in Helios+ T cell subsets in peripheral blood of early-stage lung adenocarcinoma patients: Implications for early diagnosis Immunobiology (IF 2.8) Pub Date : 2023-09-22 Yiming Zhao, Ming Zhao, Meng Li, Xiancan Ma, Mohan Zheng, Yuying Nie, Yaoyi Zhu, Jiaxin Ren, Ainizati Hasimu, Zihang Yuan, Qi Li, Ayibaota Bahabayi, Zhonghui Zhang, Xingyue Zeng, Chen Liu
Objective This study aimed to investigate the changes and significance of circulating Helios-associated T cell subsets in patients with early-stage lung adenocarcinoma (LUAD). Methods Blood samples were collected from 35 healthy controls and 34 patients with early-stage LUAD. Flow cytometry was used to analyze various CD4+ T cell subsets, including regulatory T(Treg) cells, follicular regulatory T(Tfr)
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PLEKHA4 promotes glioblastoma progression through apoptosis inhibition, tumor cell migration, and macrophage infiltration Immunobiology (IF 2.8) Pub Date : 2023-09-20 Yang He, Wenjing Zheng, Yi Huo, Longqi Sa, Han Zhang, Guangbin He, Panfeng Shang
Background Glioblastoma(GBM) has a profound impact on human health, making the identification of reliable prognostic biomarkers pivotal. While PLEKHA4 has been associated with tumor genesis and development, its role in gliomas is still uncertain. Methods We analyzed PLEKHA4 expression in tumor tissues using the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Additionally, we
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Fluid shear stress enhances dendritic cell activation Immunobiology (IF 2.8) Pub Date : 2023-09-13 Jenna A. Dombroski, Schyler J. Rowland, Abigail R. Fabiano, Samantha V. Knoblauch, Jacob M. Hope, Michael R. King
Ex vivo activation of dendritic cells (DCs) has been widely explored for targeted therapies, although these treatments remain expensive. Reducing treatment costs while enhancing cell activation could help to make immunotherapies more accessible. Cells can be activated by both internal and external forces including fluid shear stress (FSS). FSS activates cells via opening of mechanosensitive ion channels
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Targeting C5a is beneficial in critically ill COVID-19 patients Immunobiology (IF 2.8) Pub Date : 2023-09-12 Endry H.T. Lim, Alexander P.J. Vlaar, Matthijs C. Brouwer, Diederik van de Beek
Abstract not available
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Moderate and high-intensity interval training protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats Immunobiology (IF 2.8) Pub Date : 2023-09-13 Reza Sheikh, Saeid Shakerian, Seyed Reza Fatemi Tabatabaei, Abdolhamid Habibi
Diabetes Mellitus (DM) can damage the function of metabolic tissues, including the liver. Liver macrophages are the first responders to tissue damage or exercise. We sought to determine whether eight weeks of interval training (HIIT & MIIT) protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats
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Levels of soluble TNF receptors (sTNFR1 and sTNFR2) increase with clinical worsening of patients and are related to COVID-19 mortality Immunobiology (IF 2.8) Pub Date : 2023-09-15 Melayne Rocha Aciole, Juliana Prado Gonçales, Patrícia Areias Feitosa Neves, Cynthia Regina Pedrosa Soares, Marta Iglis de Oliveira, Heloisa Ramos Lacerda de Melo, Reginaldo Gonçalves de Lima Neto, Líbia Cristina Rocha Vilela Moura, Paulo Sergio Ramos Araújo, Virginia Maria Barros de Lorena
The present study aimed to inspect the serum levels of the soluble receptors, sTNFR1 and sTNFR2, in patients with COVID-19. The large production of inflammatory cytokines is an essential process in the pathogenesis of COVID-19. TNF is a multifaceted proinflammatory cytokine which has soluble and membrane receptors. Thus, knowing the role of these receptors will help better understand this disease's
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Cafeteria diet-induced obesity remodels immune response in acute Trypanosoma cruzi infection Immunobiology (IF 2.8) Pub Date : 2023-09-15 Amanda Goulart, Naira Ferreira Anchieta, Pedro Alexandre Sampaio, Vânia Brazão, Jefferson Luiz Da Silva, Gisele Bulhões Portapilla, Andressa Duarte, Daiane Yukie Tezuca, Maiara Voltarelli Providello, Angelita Maria Stabile, José Clóvis do Prado
Background Obesity is a global problem associated with several conditions, including hypertension, diabetes, arthritis and cardiovascular diseases. With the increase in the prevalence of obesity in recent years, mostly in developing countries, it is important to study its impact on various diseases, including infectious illnesses, such as Chagas disease, caused by the protozoan Trypanosoma cruzi. Considering
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Genetic polymorphisms of rs73620203 in the transforming growth interacting factor gene associated with rheumatoid arthritis in a Chinese population Immunobiology (IF 2.8) Pub Date : 2023-09-01 Huiling Tan, Ruyu Ren, Xuean Wang, Wenchuang Hu, Bin Yang
Objective To explore the association of single nucleotide polymorphisms (SNPs) in the transforming growth interacting factor (TGIF) gene with bone metabolism markers and rheumatoid arthritis (RA) susceptibility. Methods Three SNPs were genotyped in 155 RA patients and 168 healthy controls using high-resolution melting (HRM) analysis. The serum levels of osteocalcin, bone alkaline phosphatase (BALP)
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T helper type 9 cell response and its role in the neurological clinic of patients with Human T-lymphotropic virus 1 Immunobiology (IF 2.8) Pub Date : 2023-08-25 Roberto de Sena Rodrigues Júnior, Jéssica Antonia Nunes Gomes, George Alberto da Silva Dias, Satomi Fujihara, Gilberto Toshimitsu Yoshikawa, Roberta Vilela Lopes Koyama, Rita Catarina Medeiros Sousa, Juarez Antonio Simões Quaresma, Hellen Thais Fuzii
Human T-lymphotropic virus 1 (HTLV-1) affects 5–10 million individuals worldwide. Most of those infected with this virus remain asymptomatic; however, 0.25%–4% of individuals develop HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP), while 2%–4% develop adult T-cell leukemia/lymphoma (ATLL). Understanding the immune response inherent in this infection is extremely important. The role
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Lycopene alleviates food allergy by modulating the PI3K/AKT pathway in peanut-sensitized BALB/c mice Immunobiology (IF 2.8) Pub Date : 2023-08-15 Hongjuan He, Xiaoyan Ji, Lihua Cao, Zhenzhen Wang, Xiaoyu Wang, Xiu-Min Li, Mingsan Miao
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Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis Immunobiology (IF 2.8) Pub Date : 2023-08-09 Rathika D. Shenoy, , , Prakash Patil, Pavan K. Jayaswamy, Dhananjay B. Alagundagi, Praveenkumar Shetty
COVID-19 patients demonstrating hyperactive immunologic response appear to have a severe illness with a poor prognosis. This study hypothesizes that the pro-inflammatory Annexin A2 (ANXA2) has role in COVID-19 pathogenesis. In this observational study, serum levels of ANXA2 along with interleukin 1 beta (IL1β), IL6, tumour necrosis factor-alpha (TNFα), and anti-inflammatory ANXA1 were determined by
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Identification of prognostic genes for breast cancer related to systemic lupus erythematosus by integrated analysis and machine learning Immunobiology (IF 2.8) Pub Date : 2023-08-10 Xiaofeng Liang, Zhishen Peng, Zien Lin, Xiaobing Lin, Weiyi Lin, Ying Deng, Shujun Yang, Shanshan Wei
Background Systemic Lupus Erythematosus (SLE) is an autoimmune disease with multi-organ involvement, and some studies have found that SLE has a reduced risk of breast cancer (BRCA). So, we tried to find prognostic genes for BRCA related to SLE by integrated analysis and machine learning. Method First, we downloaded 2 SLE datasets from Gene Expression Omnibus (GEO) and BRCA data from the Cancer Genome
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XXIX International Complement Workshop Newcastle 2023 Immunobiology (IF 2.8) Pub Date : 2023-08-10 Kevin Marchbank
Abstract not available
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TLR-2 agonist Pam3CSK4 has no therapeutic effect on visceral leishmaniasis in BALB/c mice and may enhance the pathogenesis of the disease Immunobiology (IF 2.8) Pub Date : 2023-08-06 Xuechun Liao, Jinlei He, Ruanyan Wang, Jianhui Zhang, Shulan Wei, Yuying Xiao, Qi Zhou, Xiaoting Zheng, Zheying Zhu, Zhiwan Zheng, Jiao Li, Zheng Zeng, Dali Chen, Jianping Chen
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Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations Immunobiology (IF 2.8) Pub Date : 2023-08-09 Tiantian Cai, Jianbin Xu, Yudie Fang, Yuqing Wu, Qiu Qin, Jin-an Zhang
With the recent advancement in omics and molecular techniques, a wealth of new molecular biomarkers have become available for the diagnosis and classification of primary Sjögren's syndrome (pSS) patients. However, whether these biomarkers are universal is of great interest to us. In this study, we used various methods to obtain shared biomarkers derived from multiple tissue in pSS patients and to explore
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A retrospective observational study to estimate the risk of HLA alloimmunization with blood transfusion: Can the risk be reduced by leucodepletion? Immunobiology (IF 2.8) Pub Date : 2023-08-09 Prashant Pandey, Amit Pande, Arghyadeep Marik, Vijay Kumar Sinha, Amit Kumar Devra, Anil Prasad Bhatt, Supriya Kumari, Swapnil Yashwant Gajway, Ravi Kumar Singh, Smriti Mishra, Shantanu Jha
Background In this retrospective study, our aim was to find the effect of leucodepleted (LD) blood transfusions on the formation of anti-HLA-antibodies when compared to non-leucodepleted (non-LD) transfusions using Luminex-based method. Methods In this study, Luminex single antigen bead assay (L-SAB) and HLA typing were performed on 310 patients. Test positivity rates (as MFI - Mean florescence intensity)
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PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children Immunobiology (IF 2.8) Pub Date : 2023-08-03 Hatilla dos Santos Silva, Helena Mariana Pitangueira Teixeira, Luciano Gama da Silva Gomes, Álvaro A. Cruz, Neuza Maria Alcantara-Neves, Maurício Barreto, Camila Alexandrina Figueiredo, Ryan dos Santos Costa
PDE4D (Phosphodiesterase 4D) gene encodes a hydrolase of cyclic AMP. PDE4D genetic variants have been associated with asthma susceptibility. Therefore, this study aimed to investigate the association between PDE4D variants (and haplotypes) with asthma and atopy in a Brazilian population. The study comprised 1,246 unrelated participants from the SCAALA (Social Changes Asthma and Allergy in Latin America)
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Identification and characterization of T-cell receptors with therapeutic potential showing conserved specificity against all SARS-CoV 2 strains Immunobiology (IF 2.8) Pub Date : 2023-07-28 Hannah Reimann, Carolin Moosmann, Kilian Schober, Vanessa Lang, Johan Verhagen, Julia Zeun, Andreas Mackensen, Anita N. Kremer, Simon Völkl, Michael Aigner
Introduction Treatment of severe COVID-19 disease can be challenging in immunocompromized patients due to newly emerging virus variants of concern (VOC) escaping the humoral response. Thus, T cells recognizing to date unmutated epitopes are not only relevant for patients’ immune responses against VOC, but might also serve as a therapeutic option for patients with severe COVID-19 disease in the future
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Identification and validation of ferroptosis-related prognostic risk model and immune landscape in hepatocellular carcinoma Immunobiology (IF 2.8) Pub Date : 2023-07-26 Fei Tang, Ning Wang
Background Ferroptosis has been paid much more attention on account of the correlation with tumorigenesis and development. However, the molecular characteristics and immune landscape of ferroptosis regulators in hepatocellular carcinoma (HCC) have not been fully elucidated. Methods RNA-sequencing data and matched clinical data were collected from The Cancer Genome Atlas (TCGA) database, then underwent
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Limosilactobacillus fermentum modulates the gut-airway axis by improving the immune response through FOXP3 activation on combined allergic rhinitis and asthma syndrome (CARAS) Immunobiology (IF 2.8) Pub Date : 2023-07-26 Raquel F.P. Cavalcanti, Francisco A.A.F. Gadelha, Laércia K.D. Paiva Ferreira, Larissa A.M. Paiva Ferreira, José V. Chaves Júnior, Rayanne S. de Araújo Batista, Taynara B.L. Melo, Fábio S. de Souza, Adriano F. Alves, Leônia Maria Batista, Marcia R. Piuvezam
Combined allergic rhinitis and asthma syndrome (CARAS) is an allergic airway inflammatory disorder orchestrated by the type 2 immune response. The close gut-lung relationship has been described, however, the effect of gut-modulating agents such as probiotics in allergic airway disorder is unclear. Thus, the goal of this study was to evaluate the Limosilactobacillus fermentum supplementation in animals
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Metabolomic and proteomic analyses of primary Sjogren’s syndrome Immunobiology (IF 2.8) Pub Date : 2023-07-27 Junning Zhang, Zixing Tang, Zhenyu Liu, Guangyu Wang, Xueli Yang, Xianliang Hou
The pathogenesis of primary Sjogren’s syndrome (pSS) has not been fully elucidated. We explored differentially expressed proteins and metabolic pathways in pSS using proteomics and metabolomics. 456 named proteins in total were identified, among which 50 were significantly changed in the pSS. Altered proteins were significantly associated with signaling pathways such as antigen processing and presentation
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Clinical study of autonomic dysfunction in patients with autoimmune encephalitis Immunobiology (IF 2.8) Pub Date : 2023-07-26 Jiao He, Yajun Lian
Background Autoimmune encephalitis (AE) is a collective name, covering an emerging spectrum of autoimmune-mediated neurological diseases related to antibodies and synaptic or intracellular proteins. Anti-NMDAR, anti-LGI1, and anti-GABABR are three types of neuronal cell surface antibodies. Autonomic dysfunction represents a frequently occurring clinical manifestation. This observational study purposes
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Immunostimulatory activity and safety evaluation of Bordetella bronchiseptica-derived lipopolysaccharide, a new vaccine adjuvant candidate Immunobiology (IF 2.8) Pub Date : 2023-07-17 You-Jeong Lee, Hong-Gu Joo
Adjuvants are used to elicit strong immune responses for vaccines that show poor immunogenicity. Previously, we demonstrated that a sonicated bacterin of Bordetella bronchiseptica can be used as a safe adjuvant that enhances the antigen-presenting capability of dendritic cells (DCs). In this study, we purified the lipopolysaccharide (LPS) of B. bronchiseptica (Bb-LPS) and investigated its immunogenic
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PD1 is transcriptionally regulated by LEF1 in mature T cells Immunobiology (IF 2.8) Pub Date : 2023-07-20 Pin Zhao, Lanming Sun, Cong Zhao, Samiullah Malik
The role of programmed cell death 1 (PD1) in cancer immune evasion is of considerable importance, prompting the development of monoclonal antibodies that specifically target PD-1 to enhance the immune system for cancer therapy. Nevertheless, the efficacy of PD1/programmed cell death-Ligand 1 (PD-L1) blocking antibodies is limited to certain patients or tumor types. Although researchers have demonstrated
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Comparing the expression of MiR-223-NLRP3-IL-1β axis and serum IL-1β levels in patients with severe COVID-19 and healthy individuals Immunobiology (IF 2.8) Pub Date : 2023-07-17
Background and aim The hyperactive nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key factor for cytokine storm, chronic inflammation, and mortality in infected patients. On the subject of the regulation of the NLRP3-inflammasome activation, micro-ribonucleic