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Role of luteolin in overcoming Parkinson's disease Biofactors (IF 4.734) Pub Date : 2021-01-14 Yasir Hasan Siddique
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting elderly people (>60 years old) worldwide. There is no permanent cure for the disease but the symptomatic relief can be obtained by using dopamine agonists besides L‐dopa therapy. The longer use of the drugs is associated with several side effects. Hence, the researchers have made a considerable attention toward
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Luteolin as a modulator of skin aging and inflammation Biofactors (IF 4.734) Pub Date : 2020-12-25 Fabian Gendrisch; Philipp R. Esser; Christoph M. Schempp; Ute Wölfle
Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables and spices. It plays an important role in defending plants, for example against UV radiation by partially absorbing UVA and UVB radiation. Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti‐oxidative and anti‐inflammatory activities
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Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis Biofactors (IF 4.734) Pub Date : 2020-12-21 James W. Daily; Suna Kang; Sunmin Park
Luteolin is a widely distributed flavone herbs and vegetables. It has anti‐oxidant and anti‐inflammatory activities and improves glucose metabolism by potentiating insulin sensitivity and improving β‐cell function and mass. Alzheimer's disease (AD) is induced by the deposition of amyloid‐beta (Aβ) in the hippocampus and the formation of neurotoxic Aβ plaques. The Aβ deposition is associated with increased
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Anti‐neuroinflammatory effect of daidzein in human hypothalamic GnRH neurons in an in vitro membrane‐based model Biofactors (IF 4.734) Pub Date : 2020-12-21 Sabrina Morelli; Antonella Piscioneri; Giulia Guarnieri; Annamaria Morelli; Enrico Drioli; Loredana De Bartolo
Phytoestrogens can control high‐fat diet‐induced hypothalamic inflammation that is associated with severe consequences, including obesity, type 2 diabetes, cardiovascular and neurodegenerative diseases. However, the phytoestrogen anti‐neuroinflammatory action is poorly understood. In this study, we explored the neuroprotection mediated by daidzein in hypothalamic neurons by using a membrane‐based model
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ISSUE HIGHLIGHTS Biofactors (IF 4.734) Pub Date : 2020-12-20
874 Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells Simin Sharifi, Farzin Arablouye Moghaddam, Atefeh Abedi, Solmaz Maleki Dizaj, Shahin Ahmadian, Elaheh Dalir Abdolahinia, Seyed Mahdi Hosseiniyan Khatibi and Mohammad Samiei Medicinal plants have always been utilized for the prevention and treatment of the spread of different diseases all around the world. To name some
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An assessment of poly (ADP‐ribose) polymerase‐1 role in normal and cancer cells Biofactors (IF 4.734) Pub Date : 2020-10-24 Manoj Kumar; Rishi Kumar Jaiswal; Pramod K. Yadava; Rana P. Singh
Poly (ADP‐ribose) polymerase (PARP) is a superfamily of 18 proteins characterized by the PARP homology domain, the catalytic domain. This catalytic domain helps in the ADP‐ribosylation of various acceptor proteins using nicotinamide adenine dinucleotide (NAD+) as a donor for ADP‐ribose. PARP‐1 and PARP‐2 carry out 80% of poly‐ADP‐ribosylation of cellular protein. Hence, their combined knockout results
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Medicinal plants and bioactive natural compounds as inhibitors of HMG‐CoA reductase: A literature review Biofactors (IF 4.734) Pub Date : 2020-10-14 Atena Mahdavi; Mohammad Bagherniya; Omid Fakheran; Željko Reiner; Suowen Xu; Amirhossein Sahebkar
Cardiovascular diseases (CVDs) are one of the most important causes for mortality worldwide. Elevated levels of total cholesterol, and particularly LDL‐cholesterol (LDL‐C) are the main risk factor for acute myocardial infarction (AMI) and ischemic heart disease. The risk of CVDs could be reduced by decreasing the elevated cholesterol levels. β‐hydroxy β‐methylglutaryl‐CoA reductase (HMGCoAR) is the
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COVID‐19, microthromboses, inflammation, and platelet activating factor Biofactors (IF 4.734) Pub Date : 2020-12-09 Constantinos Demopoulos; Smaragdi Antonopoulou; Theoharis C. Theoharides
Recent articles report elevated markers of coagulation, endothelial injury, and microthromboses in lungs from deceased COVID‐19 patients. However, there has been no discussion of what may induce intravascular coagulation. Platelets are critical in the formation of thrombi and their most potent trigger is platelet activating factor (PAF), first characterized by Demopoulos and colleagues in 1979. PAF
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Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial‐mesenchymal transformation in a mouse model of myocarditis Biofactors (IF 4.734) Pub Date : 2020-11-03 Yan Fang; Zhitang Chang; Zhicheng Xu; Jing Hu; Haiwen Zhou; Songping Yu; Xuan Wan
Osteoglycin (Ogn), a class III SLRP member with multiple glycosylation sites, has been proposed to be engaged in cardiac dysfunction and adverse remodeling in human heart failure following myocardial infarction. However, the underlying mechanism remains to be elucidated. Thus, we sought to define the role of Ogn in regulation of the Wnt pathway on myocardial fibrosis and epithelial/endothelial‐mesenchymal
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Longevity effects of hispidol in Caenorhabditis elegans Biofactors (IF 4.734) Pub Date : 2020-11-12 Hyun Joo Lim; Young Taek Han; Ji‐Hye Ahn; Yong‐Deok Jeon; Hoon Jeon; Dong Seok Cha
In this study, we investigated the longevity effects of hispidol, a 6,4′‐dihydroxyaurone, using the Caenorhabditis elegans model system. Our lifespan assay data revealed that hispidol could prolong the lifespan of wild‐type worms under normal culture condition. Moreover, hispidol increased the survival rate of the worms against a heat stress condition through up‐regulated expressions of HSP‐16.2. Similarly
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Specialized proresolving mediators in infection and lung injury Biofactors (IF 4.734) Pub Date : 2020-11-28 Shayna Sandhaus; Andrew G. Swick
Specialized proresolving mediators (SPMs) are endogenous lipid metabolites of long‐chain polyunsaturated fatty acids that are involved in promoting the resolution of inflammation. Many disease conditions characterized by excessive inflammation have impaired or altered SPM biosynthesis, which may lead to chronic, unresolved inflammation. Exogenous administration of SPMs in infectious conditions has
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Berberine promotes peri‐implant osteogenesis in diabetic rats by ROS‐mediated IRS‐1 pathway Biofactors (IF 4.734) Pub Date : 2020-11-24 Jingjing Shao; Shibo Liu; Xiao Zheng; Jing Chen; Lei Li; Zhimin Zhu
Accompanying with diabetes mellitus‐induced osteoporosis (DM‐OS), diabetic patients show poor peri‐implant osteogenesis after implantation for dentition defect. Berberine (BBR), a candidate oral hypoglycemic agent, is a promising agent for treating DM‐OS. In this study, BBR was applied on DM rats and high‐glucose‐cultured bone mesenchymal stem cells (BMSCs) to investigate its therapeutic mechanism
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The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective Biofactors (IF 4.734) Pub Date : 2020-11-20 Babak Alikiaii; Mohammad Bagherniya; Gholamreza Askari; Thomas P. Johnston; Amirhossein Sahebkar
Sepsis and septic shock are still a leading cause of mortality and morbidity in intensive care units worldwide. Sepsis is an uncontrolled and excessive response of the innate immune system toward the invading infectious microbes, characterized by the hyper‐production of pro‐inflammatory mediators such as interleukin (IL)‐1β, IL‐6, tumor‐necrosis factor (TNF)‐α, and high‐mobility group box 1 (HMGB1)
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Mangiferin and organ fibrosis: A mini review Biofactors (IF 4.734) Pub Date : 2020-11-20 Lijun Zhang; Cheng Huang; Shengjie Fan
Fibrosis is the end stage of many chronic diseases, which results in organ function failure and high mortality. Mangiferin is a major constituent in mango and other 16 plants, and has been shown a variety of pharmacological effects, such as antioxidant, antibacterial, anti‐tumor, anti‐inflammation. The emerging evidence has shown that mangiferin can improve renal interstitial fibrosis, pulmonary fibrosis
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Ischemic stroke, obesity, and the anti‐inflammatory role of melatonin Biofactors (IF 4.734) Pub Date : 2020-11-02 Nuttapong Yawoot; Piyarat Govitrapong; Chainarong Tocharus; Jiraporn Tocharus
Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it. Pathologies following these conditions are associated with systemic and local inflammation. Moreover, there is increasing evidence that the susceptibility for ischemic brain damage increases substantially in experimental models of ischemic stroke with concomitant obesity. Herein, we explore the proinflammatory
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Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma Biofactors (IF 4.734) Pub Date : 2020-10-24 Duraisamy Kempuraj; Ramasamy Thangavel; Deepak D. Kempuraj; Mohammad Ejaz Ahmed; Govindhasamy Pushpavathi Selvakumar; Sudhanshu P. Raikwar; Smita A. Zaheer; Shankar S. Iyer; Raghav Govindarajan; Premkumar Nattanmai Chandrasekaran; Asgar Zaheer
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ISSUE HIGHLIGHTS Biofactors (IF 4.734) Pub Date : 2020-10-18
698 Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment Elham Gholipour, Parisa Sarvarian, Parisa Samadi, Mehdi Talebi, Aliakbar Movassaghpour, Roza Motavalli, Mohammad Hojjat‐Farsangi and Mehdi Yousefi Exosomes, as small vesicles, are released by tumor cells and tumor microenvironment (cells and function as key intercellular mediators and effects on different processes
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Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment. Biofactors (IF 4.734) Pub Date : 2020-08-14 Elham Gholipour,Parisa Sarvarian,Parisa Samadi,Mehdi Talebi,Aliakbar Movassaghpour,Roza Motavalli,Mohammad Hojjat-Farsangi,Mehdi Yousefi
Exosomes, as small vesicles, are released by tumor cells and tumor microenvironment (cells and function as key intercellular mediators and effects on different processes including tumorigenesis, angiogenesis, drug resistance, and evasion from immune system. These functions are due to exosomes' biomolecules which make them as efficient markers in early diagnosis of the disease. Also, exosomes have been
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Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction. Biofactors (IF 4.734) Pub Date : 2020-09-09 Elena Martínez-Klimova,Omar Emiliano Aparicio-Trejo,Tania Gómez-Sierra,Alexis Paulina Jiménez-Uribe,Belen Bellido,José Pedraza-Chaverri
Obstructive nephropathy favors the progression to chronic kidney disease (CKD), a severe health problem worldwide. The unilateral ureteral obstruction (UUO) model is used to study the development of fibrosis. Impairment of renal mitochondria plays a crucial role in several types of CKD and has been strongly related to fibrosis onset. Nevertheless, in the UUO model, the impairment of mitochondria, their
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MiR‐1471 protects the aggravation of non‐small‐cell lung carcinoma by targeting FOXL1 Biofactors (IF 4.734) Pub Date : 2020-10-12 Donglei Shi; Kun Zhang; Guangquan Li; Yinghao Zhao
This study detected the expression pattern of miR‐1471 in non‐small‐cell lung cancer (NSCLC) tissues, and analyzed the prognostic significance of miR‐1471 in NSCLC. Subsequently, potential targets of miR‐1471 were screened for assessing the potential molecular mechanism in NSCLC. A total of 47 primary NSCLC cases treated by radical resection and systematic lymphadenectomy in the department of thoracic
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Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5. Biofactors (IF 4.734) Pub Date : 2020-08-27 Guixiang Zhang,Yang Zhou,Manman Su,Xucheng Yang,Biyun Zeng
Osteoarthritis (OA) represents a progressive degenerative disorder that predominantly affects the synovial membranes of joints. Recent studies have highlighted the significant role played by microRNAs (miRNAs) in OA development. The current study aimed to elucidate the underlying modulatory role of miR‐27b‐3p in the development of OA. The expression of miR‐27b‐3p in the OA patients and rat models post
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Interleukin‐5 deletion promotes sepsis‐induced M1 macrophage differentiation, deteriorates cardiac dysfunction, and exacerbates cardiac injury via the NF‐κB p65 pathway in mice Biofactors (IF 4.734) Pub Date : 2020-10-11 Wanqian Liang; Jianhua Li; Caiyan Bai; Yingen Chen; Yan Li; Guotao Huang; Xuehui Wang
Inflammation plays a crucial role in sepsis‐induced cardiac injury. The purpose of this study was to determine whether interleukin‐5 (IL‐5) affected lipopolysaccharide (LPS)‐induced cardiac injury by regulating the inflammatory response. First, the expression level and source of cardiac IL‐5 were examined, and the results showed that LPS treatment and cecal ligation decreased cardiac IL‐5 expression
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Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells Biofactors (IF 4.734) Pub Date : 2020-10-09 Simin Sharifi; Farzin Arablouye Moghaddam; Atefeh Abedi; Solmaz Maleki Dizaj; Shahin Ahmadian; Elaheh Dalir Abdolahinia; Seyed Mahdi Hosseiniyan Khatibi; Mohammad Samiei
Medicinal plants have always been utilized for the prevention and treatment of the spread of different diseases all around the world. To name some traditional medicine that has been used over centuries, we can refer to phytochemicals such as naringin, icariin, genistein, and resveratrol gained from plants. Osteogenic differentiation and mineralization of stem cells can be the result of specific bioactive
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Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid‐resistant nephrotic syndrome Biofactors (IF 4.734) Pub Date : 2020-10-08 Yalda Rahbar Saadat; Seyyedeh Mina Hejazian; Ziba Nariman‐Saleh‐Fam; Milad Bastami; Arash Poursheikhani; Mohammadali M. Shoja; Mohammadreza Ardalan; Sepideh Zununi Vahed
Steroid‐resistant nephrotic syndrome (SRNS) is a clinical challenge with variable clinical outcomes. In patients with SRNS, unsuccessful anti‐inflammatory and anti‐proteinuric effects of steroids lead to end‐stage renal disease (ESRD). Our objective was to define the expression pattern of the glucocorticoid receptors (GR) α and β and their epigenetic regulators (miR‐24, miR‐30a, and miR‐370) in a group
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Evaluation of photostability and phototoxicity of esterified derivatives of ubiquinol‐10 and their application as prodrugs of reduced coenzyme Q10 for topical administration Biofactors (IF 4.734) Pub Date : 2020-10-06 Shuichi Setoguchi; Nami Nagata‐Akaho; Shotaro Goto; Hirofumi Yamakawa; Daisuke Watase; Kazuki Terada; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
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Molecular basis and therapeutic potential of myostatin on bone formation and metabolism in orthopedic disease Biofactors (IF 4.734) Pub Date : 2020-09-30 Yinxing Cui; Qian Yi; Weichao Sun; Dixi Huang; Hui Zhang; Li Duan; Hongxi Shang; Daping Wang; Jianyi Xiong
Myostatin, a member of the transforming growth factor‐β (TGF‐β) superfamily, is a key autocrine/paracrine inhibitor of skeletal muscle growth. Recently, researchers have postulated that myostatin is a negative regulator of bone formation and metabolism. Reportedly, myostatin is highly expressed in the fracture area, affecting the endochondral ossification process during the early stages of fracture
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Systematic and experimental investigations of the anti-colorectal cancer mediated by genistein. Biofactors (IF 4.734) Pub Date : 2020-09-20 Lei Zhang,Junzhi Zhang,Yizhen Gong,Lv Lv
Recent evidences have suggested that genistein, a beneficial isoflavonoid, exerts marked anti‐proliferative action on colorectal cancer (CRC) cells. However, the exact molecular mechanisms behind anti‐CRC effect of genistein have not been elucidated. In current report, a systemic pharmacology analysis was used to disclose the anti‐CRC mechanism of genistein prior to performing experimentative certification
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Nesting and fate of transplanted stem cells in hypoxic/ischemic injured tissues: The role of HIF1α/sirtuins and downstream molecular interactions. Biofactors (IF 4.734) Pub Date : 2020-09-16 Abolfazl Barzegari,Yadollah Omidi,Virginie Gueguen,Anne Meddahi-Pellé,Didier Letourneur,Graciela Pavon-Djavid
The nesting mechanisms and programming for the fate of implanted stem cells in the damaged tissue have been critical issues in designing and achieving cell therapies. The fracture site can induce senescence or apoptosis based on the surrounding harsh conditions, hypoxia, and oxidative stress (OS). Respiration deficiency, disruption in energy metabolism, and consequently OS induction change the biophysical
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Nerolidol protects the liver against cyclophosphamide-induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF-κB p65, and caspase-3 signaling molecules in Swiss albino mice. Biofactors (IF 4.734) Pub Date : 2020-09-17 Ashif Iqubal,Mansoor Ali Syed,Javed Ali,Abul Kalam Najmi,Mohammad Mahfuzul Haque,Syed Ehtaishamul Haque
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Circulating miR-155, let-7c, miR-21, and PTEN levels in differential diagnosis and prognosis of idiopathic granulomatous mastitis and breast cancer. Biofactors (IF 4.734) Pub Date : 2020-09-17 Hulya Aksan,Berrin Papila Kundaktepe,Ugurcan Sayili,Mehmet Velidedeoglu,Gonul Simsek,Selcuk Koksal,Remise Gelisgen,Ilhan Yaylim,Hafize Uzun
This study investigates whether the circulating miR‐155, let‐7c, miR‐21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). Forty‐five patients with BC, 50 patients with IGM, and 48 healthy volunteers were included in the study. Serum miR‐21 expression was significantly higher in BC (fold change = 2.42) and IGM group
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ISSUE HIGHLIGHTS Biofactors (IF 4.734) Pub Date : 2020-08-17
502 A systematic review and meta‐analysis of the effect of Vitamin D‐fortified food on glycemic indices Maryam Emadzadeh, Reza Sahebi, Hamed Khedmatgozar, Ramin Sadeghi, Mahsa Farjami, Payam Sharifan, Yalda Ravanshad, Gordon A. Ferns and Majid Ghayour‐Mobarhan Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta‐analysis was to
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Resolvin D1 protects against sepsis-induced cardiac injury in mice. Biofactors (IF 4.734) Pub Date : 2020-07-15 Menglong Wang,Menglin Liu,Jishou Zhang,Jianfang Liu,Jing Ye,Yao Xu,Zhen Wang,Di Ye,Mengmeng Zhao,Jun Wan
Increased inflammation is the key mechanism that mediates sepsis induced cardiac injury. Resolvin D1 (RvD1), a bioactive lipid mediator synthesized from docosahexaenoic acid, can attenuate the severity of many inflammation‐related diseases through anti‐inflammatory and pro‐resolving properties. However, the protective role of RvD1 in sepsis induced cardiac injury remains unclear. Mice were randomly
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Exosomal LINC01005 derived from oxidized low-density lipoprotein-treated endothelial cells regulates vascular smooth muscle cell phenotypic switch. Biofactors (IF 4.734) Pub Date : 2020-07-14 Zhiliang Zhang,Dasong Yi,Jiamin Zhou,Yaofu Zheng,Zhiming Gao,Xiaoliang Hu,Guoqiu Ying,Xiaoping Peng,Tong Wen
Phenotype switch of vascular smooth muscle cells (VSMCs) plays an important role in the development of atherosclerosis (AS). Endothelial cells can regulate VSMC phenotypic switch by secreting exosomes, crucial mediators of intracellular communication. This study aimed to determine whether exosomal LINC01005 from oxidized low‐density lipoprotein (ox‐LDL)‐treated human umbilical vein endothelial cells
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Butein inhibits lipogenesis in Caenorhabditis elegans. Biofactors (IF 4.734) Pub Date : 2020-07-14 Renalison Farias-Pereira,Zhenyu Zhang,Cheon-Seok Park,Daeyoung Kim,Kee-Hong Kim,Yeonhwa Park
Butein, a flavonoid found in annatto seeds and lacquer trees, may be used for many health benefits, including the prevention of obesity. However, its anti‐obesity effects are not completely understood; in particular, the effects of butein on the regulation of lipid metabolism have not been explained. Thus, the goal of the current study was to determine the effects of butein on lipid metabolism in Caenorhabditis
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C. elegans ACAT regulates lipolysis and its related lifespan in fasting through modulation of the genes in lipolysis and insulin/IGF-1 signaling. Biofactors (IF 4.734) Pub Date : 2020-07-08 Juan Bai,Renalison Farias-Pereira,Yuan Zhang,Miran Jang,Yeonhwa Park,Kee-Hong Kim
Overly active acyl‐coenzyme A: cholesterol acyltransferases (ACATs) are known to contribute to the development of atherosclerosis, cancer cell proliferation and de novo lipogenesis. However, the role of ACAT in systemic lipid metabolism and its consequence of aging is unknown. Using avasimibe, a clinically proven ACAT inhibitor, and mboa‐1 mutant strain, a homologous to mammalian ACAT, herein, we found
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Cyanidin-3-O-glucoside attenuates endothelial cell dysfunction by modulating miR-204-5p/SIRT1-mediated inflammation and apoptosis. Biofactors (IF 4.734) Pub Date : 2020-06-27 Zhihong Wang,Min Zhang,Zhong Wang,Zongjun Guo,Zongqiu Wang,Qun Chen
Endothelial cell (EC) dysfunction is a major symptom associated with the initiation of atherosclerosis (AS). Cyanidin‐3‐O‐glucoside (C3G) has the potentials to attenuate AS symptoms. In the current study, the mechanism driving the effects of C3G on AS rabbits and injured ECs were explored by focusing on the changes in miR‐204‐5p/SIRT1 axis. AS symptoms were induced in rabbits using high‐fatty diet
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POTEE stimulates the proliferation of pancreatic cancer by activating the PI3K/Akt/GSK-3β/β-catenin signaling. Biofactors (IF 4.734) Pub Date : 2020-06-26 Qingya Hao,Lihua Gao,Wenyang Niu,Liang Chen,Peng Zhang,Zhong Chen
To explore the role of POTEE in the malignant development of pancreatic cancer and the possible mechanism. POTEE levels in pancreatic cancer samples were detected. The relationship between POTEE level and clinical data of pancreatic cancer patients was analyzed. After knockdown of POTEE or treatment of the GSK‐3β inhibitor, proliferative change in pancreatic cancer cells was assessed. Protein levels
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Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines. Biofactors (IF 4.734) Pub Date : 2020-06-25 Wei Cui,Jun Xue
Both circular RNA DOCK1 (circDOCK1) and microRNA‐124 (miR‐124) are implicated in carcinogenesis, but functional association between these two molecules remains uncharacterized. Here, we aimed to ascertain the role of circDOCK1‐miR‐124 node in thyroid cancer cells.
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ISSUE HIGHLIGHTS Biofactors (IF 4.734) Pub Date : 2020-06-12
306 COVID‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin Theoharis C. Theoharides The recent corona virus [severe acute pulmonary syndrome (SARS‐CoV‐2)] infects cells, especially in the lungs, via its spike protein binding to a receptor on the surface called Angiotensin Converting Enzyme 2 (ACE2). Pulmonary mast cells express this receptor making them prime targets, following
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LncRNA H19 aggravates TNF-α-induced inflammatory injury via TAK1 pathway in MH7A cells. Biofactors (IF 4.734) Pub Date : 2020-06-11 Jialiang Yang,Yixuan Li,Lili Wang,Zhenchun Zhang,Zunzhong Li,Qian Jia
Rheumatoid arthritis (RA) is a common chronic autoimmune disease in women. This research aims to disclose the probable function of lncRNA H19 in MH7A cells.
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Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number. Biofactors (IF 4.734) Pub Date : 2020-06-01 Roberta Ricciarelli,Angelo Azzi,Jean-Marc Zingg
Cell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors (stress‐induced premature senescence, SIPS). With the acquisition of the senescence‐associated secretory phenotype (SASP), cells release several molecules (cytokines, proteases, lipids)
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The roles of melatonin on kidney injury in obese and diabetic conditions. Biofactors (IF 4.734) Pub Date : 2020-05-24 Sasivimon Promsan,Anusorn Lungkaphin
Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. The expansion of adipocytes triggers proinflammatory
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Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma. Biofactors (IF 4.734) Pub Date : 2020-05-24 Fangxian Liu,Qijin Pan,Liangliang Wang,Shijiang Yi,Peng Liu,Wenjun Huang
Calycosin is a naturally occurring phytoestrogen, and it has the anti‐nasopharyngeal carcinoma (NPC) action played by calycosin. However, the elaborate mechanisms of calycosin treating NPC remain to be unrevealed. In current report, a promising tool of network pharmacology method was used to uncover the anti‐NPC targets and therapeutic mechanisms played by calycosin. Furthermore, were conducted to
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New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors. Biofactors (IF 4.734) Pub Date : 2020-05-22 Solmaz Mohammadi,Reza Arefnezhad,Shahla Danaii,Mehdi Yousefi
As an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGFβ, Notch, and EGFR signaling leaves effect on the proliferation
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Dicer and Drosha expression in patients with nephrotic syndrome. Biofactors (IF 4.734) Pub Date : 2020-05-15 Seyyedeh Mina Hejazian,Yalda Rahbar Saadat,Zahra Bahmanpour,Seyed Mahdi Hosseiniyan Khatibi,Mohammadreza Ardalan,Sepideh Zununi Vahed
Podocytes play an essential role in the regulation of glomerular filtration and the appropriate function of the kidney. Podocytes injury is involved in the pathogenesis of nephrotic syndrome (NS), a common renal glomerulus dysfunction characterized by proteinuria. Some in vivo studies in Dicer/Drosha knockout mice indicate the importance of Dicer, Drosha, and microRNAs (miRNAs) in the pathogenesis
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High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors (IF 4.734) Pub Date : 2020-05-08 Perinur Bozaykut,Ruchan Ekren,Osman Ugur Sezerman,Vadim N Gladyshev,Nesrin Kartal Ozer
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A systematic review and meta-analysis of the effect of Vitamin D-fortified food on glycemic indices. Biofactors (IF 4.734) Pub Date : 2020-04-29 Maryam Emadzadeh,Reza Sahebi,Hamed Khedmatgozar,Ramin Sadeghi,Mahsa Farjami,Payam Sharifan,Yalda Ravanshad,Gordon A Ferns,Majid Ghayour-Mobarhan
Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta‐analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, for randomized controlled trials that were published
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COVID‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin Biofactors (IF 4.734) Pub Date : 2020-04-27 Theoharis C. Theoharides
The new coronavirus (severe acute pulmonary syndrome [SARS]‐CoV‐2) originated in China, where it spread rapidly,1 and has reached pandemic proportions because of its high rate of infectivity as well as high morbidity and mortality, associated with COVID‐19.2 This coronavirus infects by first binding to the ectoenzyme angiotensin‐converting enzyme 2 (ACE2),3, 4 a serine protease acting as the receptor
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Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF‐β1/α‐SMA/Col I and III pathway Biofactors (IF 4.734) Pub Date : 2020-03-31 Linlin Bai, Aimin Li, Cuike Gong, Xuecong Ning, Zhihua Wang
Lung fibrosis is a progressive fatal lung disorder with significantly high mortality rates. Bleomycin (BLM) is one of the most commonly used chemotherapeutic agents for the treatment of several carcinomas. The most severe adverse effect of BLM is lung toxicity; therefore, BLM has been repeatedly reported to be considered amongst the most widely used agents for the induction of experimental lung fibrosis
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Plasmatic lipocalin‐2 levels in chronic low‐grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency Biofactors (IF 4.734) Pub Date : 2020-03-20 Diego Currò, Edoardo Vergani, Carmine Bruno, Simone Comi, Claudia D'Abate, Antonio Mancini
Lipocalin‐2 (LCN2) is a secreted glycoprotein involved in several chronic inflammatory processes. Metabolic syndrome (MetS) and adult growth hormone deficiency (GHD) are known as chronic inflammatory conditions. The primary objective of this observational cross‐sectional study was to compare LCN2 plasmatic levels in these clinical settings, whereas the secondary objective was to investigate any possible
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Skullcapflavone I has a potent anti‐pancreatic cancer activity by targeting miR‐23a Biofactors (IF 4.734) Pub Date : 2020-03-06 Jing Cui; Hao Li; Ying Wang; Tian Tian; Chao Liu; Yanan Wang; Shukai Sun; Baisui Feng
Baicalein has been widely studied and showed a potent activity against pancreatic cancer in both in vivo and in vitro studies. Little is known regarding the effects of Skullcapflavone I (SFI), despite they have similar structures. So, this study was to explore the function of SFI on human pancreatic cancer. Panc‐1 cells were transfected with miR‐23a precursor, miR‐23a inhibitor or the negative controls
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CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2. Biofactors (IF 4.734) Pub Date : 2020-02-27 Xiaofeng Shi,Wei Ma,Yongqi Li,Han Wang,Shuang Pan,Yongquan Pan,Caiming Xu,Lei Li
The aim of this study was to investigate the possible influences of circPRKCI abnormal expression on lipopolysaccharide (LPS)‐induced HK2 cell injury and its mechanism. The circPRKCI level was identified in serum samples from patients with urosepsis and healthy subjects, as well as LPS‐treated HK2 cells by qRT‐PCR. Cell viability, apoptosis, expression of proteins associated with apoptosis, and expression
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Anti-invasive effect and pharmacological mechanism of genistein against colorectal cancer. Biofactors (IF 4.734) Pub Date : 2020-02-20 Xiaoyu Chen,Youjun Wu,Junzhao Gu,Ping Liang,Meizhen Shen,Jiaxi Xi,Jian Qin
Colorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti‐CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Our previous experiments report that genistein exerts beneficial effects to inhibit
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Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway. Biofactors (IF 4.734) Pub Date : 2020-02-20 Pengxin Zhao,Zhigang Hu,Weiyuan Ma,Leilei Zang,Zhisheng Tian,Qian Hou
Quercetin is a plant flavonoid and has antioxidative properties. In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L‐thyroxin (LT4)‐induced hyperthyroidism rats. LT4 was used to prepare the experimental hyperthyroidism model via the intraperitoneal injection. Quercetin was injected at a series doses (5, 50, and 100 mg/kg) to LT4‐induced hypothyroidism rats once
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LncRNA TTN-AS1 acts as sponge for miR-15b-5p to regulate FBXW7 expression in ovarian cancer. Biofactors (IF 4.734) Pub Date : 2020-02-12 Sheng Miao,Jia Wang,Lili Xuan,Xiaojun Liu
Emerging evidence showed that long noncoding RNA (lncRNA) plays crucial roles in regulating various cancer biological behaviors. Titin‐antisense RNA1 (TTN‐AS1) has been reported to have crucial roles in cancers but its role in ovarian cancer remains unknown. The levels of TTN‐AS1, microNRA‐15b‐5p (miR‐15b‐5p), and F‐box and WD repeat domain containing 7 (FBXW7) in ovarian cancer cells were measured
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Circular RNA-0072309 has antitumor influences in Hep3B cell line by targeting microRNA-665. Biofactors (IF 4.734) Pub Date : 2020-02-11 Qiuyun Yu,Jinhua Dai,Ming Shu
Liver cancer is a malignant tumor that occurs in the liver and has a high mortality rate. We strived to detect the role and mechanism of circRNA-0072309 in liver cancer. Hep3B cell line was transfected with pc-circ and si-circ for viability, colony formation, apoptosis, migration, and invasion tests, which were individually performed by CCK-8, colony formation detection, flow cytometry assay, migration
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6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance. Biofactors (IF 4.734) Pub Date : 2020-02-10 Iqra Sarfraz,Azhar Rasul,Ghulam Hussain,Muhammad Ajmal Shah,Ameer Fawad Zahoor,Muhammad Asrar,Zeliha Selamoglu,Xin-Ying Ji,Şevki Adem,Satyajit D Sarker
Reprogrammed metabolism is key biochemical characteristic of malignant cells, which represents one of the emerging hallmarks of cancer. Currently, there is rising contemplation on oxidative pentose phosphate pathway (PPP) enzymes as potential therapeutic hits due to their affiliation with tumor metabolism. 6‐Phosphogluconate dehydrogenase (6PGD), third oxidative decarboxylase of PPP, has received a
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Dysfunction of thioredoxin triggers inflammation through activation of autophagy in chicken cardiomyocytes. Biofactors (IF 4.734) Pub Date : 2020-02-07 Jie Yang,Yafan Gong,Jingzeng Cai,Qi Liu,Yuan Zhang,Yingying Zheng,Dahai Yu,Ziwei Zhang
Thioredoxin (Txn) is a hydrogen carrier protein and exists widely in organism. Txn deficiency implicates cardiomyocytes injury has been proven. However, the exact mechanism remains unclear. To understand the mechanistic response of cardiomyocytes subsequent to Txn suppression, we established the model of Txn dysfunction by employing gene interference technology (siRNA) and Txn inhibitor (PX‐12) in
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Insulin-like growth factor-II and bioactive proteins containing a part of the E-domain of pro-insulin-like growth factor-II. Biofactors (IF 4.734) Pub Date : 2020-02-06 Jaap van Doorn
Insulin‐like growth factor (IGF)‐II is considered to function as an important fetal growth factor, which is structurally and functionally related to IGF‐I and proinsulin. At least in vitro, IGF‐II actions are mediated through the IGF‐I receptor and to a lesser extent the insulin receptor. After birth, the function of IGF‐II is less clear although in adults the serum level of IGF‐II exceeds that of
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MicroRNA-31 weakens cisplatin resistance of medulloblastoma cells via NF-κB and PI3K/AKT pathways. Biofactors (IF 4.734) Pub Date : 2020-02-06 Hui Ma,Wei Cao,Meili Ding
Medulloblastoma (MB) is a malignant intracranial tumor. Cisplatin is a broad‐spectrum antitumor drug. It is important to study the cisplatin resistance of MB cells for the treatment of MB. In this article, we preliminarily studied the cisplatin resistance of microRNA (miR)‐31 and the possible mechanism in DAOY and UW228 cells, laying a theoretical foundation for clinical treatment of MB.
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