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The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-03-13 Wen-Ning Xu, Huo-Liang Zheng, Run-Ze Yang, Yuan-Fang Sun, Bi-Rong Peng, Chun Liu, Jian Song, Sheng-Dan Jiang, Li-Xin Zhu
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Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-03-07 Jie Dong, Qian Xu, Chenxi Qian, Lu Wang, Alison DiSciullo, Jun Lei, Hui Lei, Song Yan, Jingjing Wang, Ni Jin, Yujing Xiong, Jianhua Zhang, Irina Burd, Xiaohong Wang
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RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-02-20 Jinxiang Zhu, Longwei Guo, Hao Dai, Zhiwei Zheng, Jinfeng Yan, Junsong Liu, Shaoqiang Zhang, Xiang Li, Xin Sun, Qian Zhao, Chongwen Xu
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Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-02-13 Jie Zhou, Dan Guo, Zhen-Zhen Xu, Jia-Shun Liao, Xiao-Ting Li, Ke Duan, Shi-You Chen, Wei-Bing Xie
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Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-02-10
Abstract V-type immunoglobulin domain–containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulator, plays an essential role in allergic pulmonary inflammation in mice. Treatment with a VISTA agonistic antibody could significantly improve asthma symptoms. Thus, for allergic asthma treatment, VISTA targeting may be a compelling approach. In this study, we examined the functional
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CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-02-06 Hui Liu, Wentong Guo, Tianxiang Wang, Peichang Cao, Tingfeng Zou, Ying Peng, Tengteng Yan, Chenzhong Liao, Qingshan Li, Yajun Duan, Jihong Han, Baotong Zhang, Yuanli Chen, Dahai Zhao, Xiaoxiao Yang
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Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-02-06
Abstract Neutrophils play a crucial role in the immune system within tumor microenvironment. At present, numerous studies have explored the changes of neutrophils’ automatic killing effect and cellular communication with other immune cells under pathological conditions through single-cell sequencing. However, there remains a lack of definite conclusion about the identification criteria of neutrophil
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Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1 Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-02-05 Yang Yang, Jianrui Li, Chuanyuan Wei, Lu Wang, Zixu Gao, Kangjie Shen, Yinlam Li, Ming Ren, Yu Zhu, Yiteng Ding, Chenlu Wei, Tianyi Zhang, Shaoluan Zheng, Nanhang Lu, Jianying Gu
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METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-02-02 Wenjie Su, Xiang Yu, Shan Wang, Xu Wang, Zheng Dai, Yi Li
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LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-01-25
Abstract Background Colorectal cancer (CRC) is a leading cause of cancer mortality globally. Lymph node metastasis and immunosuppression are main factors of poor prognosis in CRC patients. Lysyl oxidase like 1 (LOXL1), part of the lysyl oxidase (LOX) family, plays a yet unclear role in CRC. This study aimed to identify effective biomarkers predictive of prognosis and efficacy of immunotherapy in CRC
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POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-01-25
Abstract Objective This study investigated the effect and mechanism of POU6F1 and lncRNA-CASC2 on ferroptosis of gastric cancer (GC) cells. Methods GC cells treated with erastin and RSL3 were detected for ferroptosis, reactive oxygen species (ROS) level, and cell viability. The expression levels of POU6F1, lncRNA-CASC2, SOCS2, and ferroptosis-related molecules (GPX4 and SLC7A11) were also measured
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TFEB and TFE3 cooperate in regulating inorganic arsenic-induced autophagy-lysosome impairment and immuno-dysfunction in primary dendritic cells Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-01-25 Guowei Xu, Huaguang Peng, Ran Yao, Yuqing Yang, Bing Li
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circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-01-25 Wensi Wu, Zhi Wang, Huiying Zhang, Xiaojun Zhang, Hui Tian
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m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-01-25
Abstract 3-Methylcholanthracene (3-MC) is one of the most carcinogenic polycyclic aromatic hydrocarbons (PAHs). Long-term exposure to PAHs has been thought of as an important factor in urothelial tumorigenesis. N6-methyladenosine (m6A) exists widely in eukaryotic organisms and regulates the expression level of specific genes by regulating mRNA stability, translation efficiency, and nuclear export efficiency
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ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-01-22 Yujun Luo, Yiming Lei, Haoxiong Zhou, Yan Chen, Huiling Liu, Jie Jiang, Chengfang Xu, Bin Wu
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Deficiency of copper responsive gene stmn4 induces retinal developmental defects Cell Biol. Toxicol. (IF 6.1) Pub Date : 2024-01-22
Abstract As part of the central nervous system (CNS), the retina senses light and also conducts and processes visual impulses. The damaged development of the retina not only causes visual damage, but also leads to epilepsy, dementia and other brain diseases. Recently, we have reported that copper (Cu) overload induces retinal developmental defects and down-regulates microtubule (MT) genes during zebrafish
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Urinary extracellular vesicles prevent di-(2-ethylhexyl) phthalate-induced hypospadias by facilitating epithelial–mesenchymal transition via PFN2 delivery Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-11-13 Shibo Zhu, Xiangliang Tang, Jin Zhang, Jinhua Hu, Xiaofeng Gao, Dian Li, Wei Jia
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Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-11-14 Cai-Feng Yue, Ju-Gao Chen, Zi-Yue Li, Lai-Sheng Li, Jie-Rong Chen, Hai-Xia Xie, Bin Zhang, Yun-Miao Guo
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SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-10-31 Shuo Cao, Di Wang, Ping Wang, Yunhui Liu, Weiwei Dong, Xuelei Ruan, Libo Liu, Yixue Xue, Tiange E, Hongda Lin, Xiaobai Liu
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Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-10-27 Silin Liu, Chongkai Fang, Chong Zhong, Jing Li, Qingzhong Xiao
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NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-10-19 Jian Zhang, Lingyan Zhang, Gang Yao, Hai Zhao, Shuguang Wu
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GPC3-IL7-CCL19-CAR-T primes immune microenvironment reconstitution for hepatocellular carcinoma therapy Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-10-19 Li-Li Lu, Shu-xiu Xiao, Zhi-yuan Lin, Jin-jin Bai, Wei Li, Zheng-qing Song, Yu-hong Zhou, Bin Lu, Wei-Zhong Wu
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Andrographolide attenuated MCT-induced HSOS via regulating NRF2-initiated mitochondrial biogenesis and antioxidant response Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-10-11 Zhenlin Huang, Zeqi Wu, Jingnan Zhang, Keke Wang, Qing Zhao, Minwei Chen, Shihao Yan, Qian Guo, Yun Ma, Lili Ji
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circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-10-09 Qianhua Luo, Junzheng Li, Haixiong Miao, Siman Su, Yun Chen, Chengcheng Xu, Chengkuan Zhao, Jianxiang Huang, Kai Ling, Chaoxian Lin, Hongfei Yan, Shuyao Zhang
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Imatinib and M351-0056 enhance the function of VISTA and ameliorate the development of SLE via IFN-I and noncanonical NF-κB pathway Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-10-07 Lu Yang, Tingting Zhang, Penglu Wang, Wenting Chen, Wanmei Liu, Xiaoyu He, Yuxin Zhang, Shasha Jin, Zhijie Luo, Zunjian Zhang, Xinzhi Wang, Jun Liu
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Single-cell RNA sequencing reveals differences between force application and bearing in ankle cartilage Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-10-03 Junjie Wang, Zewen Sun, Chenghao Yu, Haibo Zhao, Mingyue Yan, Shenjie Sun, Xu Han, Tingting Jiang, Tianrui Wang, Tengbo Yu, Yingze Zhang
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Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-09-27 Chin-King Looi, Lian-Chee Foong, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Ee-Mun Loo, Chee-Onn Leong, Chun-Wai Mai
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Targeting autophagy with SAR405 alleviates doxorubicin-induced cardiotoxicity Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-09-28 Xiaofan Sun, Juan Du, Heng Meng, Fangshu Liu, Nianhui Yang, Suqi Deng, Heng Wan, Dewei Ye, Erfei Song, Hui Zeng
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LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-09-18 Wei Wang, Zhiruo Miao, Xue Qi, Bing Wang, Qingqing Liu, Xu Shi, Shiwen Xu
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Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-08-21 Changuk Kim, Woori Kwak, Dong-Hoon Won, Jina Kim, Da-Bin Hwang, Nahyun Kim, Minhwa Kang, Young Jeon, Yong Il Park, Jun Won Park, Jun-Won Yun
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GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-08-19 Xiaoxia Dong, Yahui Leng, Tian Tian, Qing Hu, Shuang Chen, Yufeng Liu, Li Shen
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USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-08-03 Yunli Chang, Lingling Chen, Jie Tang, Guoyu Chen, Jieru Ji, Ming Xu
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Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-08-02 Jiandong Sun, Xiuli Lian, Chengyu Lv, Hua Li, Zihang Lin, Shanshan Luo, Yue Liu, Yinglin Xu, Xia Jiang, Weiwei Xu, Shumin Liao, Zhangting Chen, Shie Wang
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Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-07-27 Zhiyuan Su, Zhuoliang Liu, Wenjing Lei, Kai Xia, An Xiao, Zheng Hu, Miaomiao Zhou, Fengxin Zhu, Jianwei Tian, Manqiu Yang, Dong Wang, Andy Peng Xiang, Jing Nie
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Pyroptosis in neurodegenerative diseases: from bench to bedside Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-07-26 Ke-jia Wu, Wan-rong Wang, Qian-hui Cheng, Hao Li, Wei-zhen Yan, Fei-ran Zhou, Rui-jie Zhang
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Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-07-18 Xuanqi Liu, Linlin Zhang, Bijun Zhu, Yifei Liu, Liyang Li, Jiayun Hou, Mengjia Qian, Nannan Zheng, Yiming Zeng, Chengshui Chen, Ajay Goel, Xiangdong Wang
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Tungsten toxicity on kidney tubular epithelial cells induces renal inflammation and M1-macrophage polarization Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-06-27 Jonatan Barrera-Chimal, Nathalie Henley, Michael Philip Grant, Schrodinger Cenatus, Pedro Geraldes, Vincent Pichette, Casimiro Gerarduzzi
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Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-06-23 Giada Carta, Wanda van der Stel, Emma W. J. Scuric, Liliana Capinha, Johannes Delp, Susanne Hougaard Bennekou, Anna Forsby, Paul Walker, Marcel Leist, Bob van de Water, Paul Jennings
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Targeting epigenetic deregulations for the management of esophageal carcinoma: recent advances and emerging approaches Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-06-20 Parul Ahuja, Ritu Yadav, Sandeep Goyal, Chetna Yadav, Shalu Ranga, Lokesh Kadian
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Brain pericytes in culture display diverse morphological and functional phenotypes Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-06-16 Lachlan S. Brown, Natalie E. King, Jo-Maree Courtney, Robert J. Gasperini, Lisa Foa, David W. Howells, Brad A. Sutherland
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The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-06-16 Min Zhou, Joelle C. Boulos, Sabine M. Klauck, Thomas Efferth
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Extracellular vesicles derived from paclitaxel-sensitive nasopharyngeal carcinoma cells deliver miR-183-5p and impart paclitaxel sensitivity through a mechanism involving P-gp Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-06-10 Xiangguo Cui, Yu Chen, Lanqing Zhao, Xiaoxu Ding
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GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc–/GSH/GPX4 Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-06-02 Ying Wang, Ting Wang, Qian Xiang, Na Li, Jun Wang, Jiahao Liu, Yan Zhang, Tao Yang, Jinjun Bian
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T-cell senescence induced by peripheral phospholipids Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-06-01 Mingyue Ma, Ying Yang, Zhouyi Chen, Xiaoyan Li, Zhicheng Yang, Ke Wang, Xusuo Li, Hao Fang, Yunfeng Cheng, Tiankui Qiao, Xin Zou, Zhiqiang Lu, Xiangdong Wang, Duojiao Wu
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Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-05-29 Yuhao Zhao, Lei Du, Jiali Sun, Xuelian Wang, Zhilei Cong, Shuyan Chen, Fei Wang, Zhen Li
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A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-05-04 Sabina Ramirez-Hincapie, Barbara Birk, Philipp Ternes, Varun Giri, Volker Haake, Michael Herold, Franziska Maria Zickgraf, Andreas Verlohner, Hans-Albrecht Huener, Hennicke Kamp, Peter Driemert, Robert Landsiedel, Elke Richling, Dorothee Funk-Weyer, Bennard van Ravenzwaay
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Potential functions and therapeutic implications of glioma-resident mesenchymal stem cells Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-05-03 Qing Zhang, Jialin Wang, Junwen Zhang, Fusheng Liu
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Correction to: YY1 inactivated transcription co‐regulator PGC‐1α to promote mitochondrial dysfunction of early diabetic nephropathy‐associated tubulointerstitial fibrosis Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-04-28 Tingting Yang, Yinlu Hu, Shangxiu Chen, Lin Li, Xinyun Cao, Jiayu Yuan, Fanglin Shu, Zhenzhou Jiang, Sitong Qian, Xia Zhu, Chujing Wei, Rui Wei, Meng Yan, Chenlin Li, Xiaoxing Yin, Qian Lu
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Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-04-25 Jin Yang, Xiaobai Liu, Yubo Zhao, Weiwei Dong, Yixue Xue, Xuelei Ruan, Ping Wang, Libo Liu, Tiange E, Jian Song, Zheng Cui, Yunhui Liu
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GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-04-24 Konstantina Bampali, Filip Koniuszewski, Florian D. Vogel, Jure Fabjan, Christos Andronis, Eftychia Lekka, Vassilis Virvillis, Thomas Seidel, Annie Delaunois, Leandro Royer, Michael G. Rolf, Chiara Giuliano, Martin Traebert, Gautier Roussignol, Magali Fric-Bordat, Ludmilla Mazelin-Winum, Sharon D. Bryant, Thierry Langer, Margot Ernst
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SNORD17-mediated KAT6B mRNA 2’-O-methylation regulates vasculogenic mimicry in glioblastoma cells Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-04-14 Jingyi Cui, Xiaobai Liu, Weiwei Dong, Yunhui Liu, Xuelei Ruan, Mengyang Zhang, Ping Wang, Libo Liu, Yixue Xue
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Early transcriptomic signatures and biomarkers of renal damage due to prolonged exposure to embedded metal Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-04-14 Yuan Wen, Ivan J. Vechetti, Dongliang Leng, Alexander P. Alimov, Taylor R. Valentino, Xiaohua D. Zhang, John J. McCarthy, Charlotte A. Peterson
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P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-04-13 Yeping Yu, Ling Chang, Qingluan Hu, Jianjun Zhu, Jianjun Zhang, Qiang Xia, Jie Zhao
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Therapeutic values of engineered immune cells: a precision-guided weapon. Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-04-11 Xuanqi Liu,Fanming Liu,Mingzhi Cai,Hao Fang
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The mtDNA-STING pathway plays an important role in both navitoclax- and S63845-induced autophagy and enhances cell death Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-03-31 Jia Jia, Mengqing Li, Yunjian Li, Jun Xiao, Haiming Dai
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Assay conditions for estimating differences in base excision repair activity with Fpg-modified comet assay Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-03-17 Congying Zheng, Andrew Collins, Gunnar Brunborg, Frederik-Jan van Schooten, Anne Lene Nordengen, Sergey Shaposhnikov, Roger Godschalk
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The method of sinus node-like pacemaker cells from human induced pluripotent stem cells by BMP and Wnt signaling Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-03-01 Fengyuan Wang, Lin Yin, Wei Zhang, Yanhong Tang, Xi Wang, Congxin Huang
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EGR1 is crucial for the chlorogenic acid–provided promotion on liver regeneration and repair after APAP-induced liver injury Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-02-21 Mengjuan Wei, Xinnan Gu, Han Li, Zhiyong Zheng, Zhimiao Qiu, Yuchen Sheng, Bin Lu, Zhengtao Wang, Lili Ji
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Induced pluripotent stem cell–derived extracellular vesicles overexpressing SFPQ protect retinal Müller cells against hypoxia-induced injury Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-02-15 Wenjun Jiao, Weifang Li, Tianyi Li, Tao Feng, Cong Wu, Di Zhao
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PM2.5 exposure increases dry eye disease risks through corneal epithelial inflammation and mitochondrial dysfunctions Cell Biol. Toxicol. (IF 6.1) Pub Date : 2023-02-14 Donghui Yu, Wenting Cai, Tianyi Shen, Yan Wu, Chengda Ren, Tingting Li, Chengyu Hu, Meijiang Zhu, Jing Yu