当前期刊: Cells Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Modeling Adipogenesis: Current and Future Perspective
    Cells (IF 4.366) Pub Date : 2020-10-20
    Hisham F. Bahmad; Reem Daouk; Joseph Azar; Jiranuwat Sapudom; Jeremy C. M. Teo; Wassim Abou-Kheir; Mohamed Al-Sayegh

    Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body. Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue. Adipose-derived stem cells’ differentiation serves well beyond the simple goal of producing new adipocytes. Indeed, with the current immense biotechnological advances, the most critical role of adipose-derived

    更新日期:2020-10-20
  • Alternative Splicing: Recent Insights into Mechanisms and Functional Roles
    Cells (IF 4.366) Pub Date : 2020-10-20
    Claudia Ghigna; Maria Paola Paronetto

    Note: In lieu of an abstract, this is an excerpt from the first page. Alternative splicing generates multiple protein isoforms from one primary transcript and represents one of the major drivers of proteomic diversity in human cells [...]

    更新日期:2020-10-20
  • In Vivo Remodeling of Altered Autophagy-Lysosomal Pathway by a Phosphopeptide in Lupus
    Cells (IF 4.366) Pub Date : 2020-10-20
    Fengjuan Wang; Inmaculada Tasset; Ana Maria Cuervo; Sylviane Muller

    The phosphopeptide P140/Lupuzor, which improves the course of lupus disease in mice and patients, targets chaperone-mediated autophagy (CMA), a selective form of autophagy that is abnormally upregulated in lupus-prone MRL/lpr mice. Administered intravenously to diseased mice, P140 reduces the expression level of two major protein players of CMA, LAMP2A and HSPA8, and inhibits CMA in vitro in a cell

    更新日期:2020-10-20
  • Complexity of Brassica oleracea–Alternaria brassicicola Susceptible Interaction Reveals Downregulation of Photosynthesis at Ultrastructural, Transcriptional, and Physiological Levels
    Cells (IF 4.366) Pub Date : 2020-10-20
    Violetta Katarzyna Macioszek; Magdalena Gapińska; Agnieszka Zmienko; Mirosław Sobczak; Andrzej Skoczowski; Jakub Oliwa; Andrzej Kiejstut Kononowicz

    Black spot disease, caused by Alternaria brassicicola in Brassica species, is one of the most devastating diseases all over the world, especially since there is no known fully resistant Brassica cultivar. In this study, the visualization of black spot disease development on Brassica oleracea var. capitata f. alba (white cabbage) leaves and subsequent ultrastructural, molecular and physiological investigations

    更新日期:2020-10-20
  • Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum
    Cells (IF 4.366) Pub Date : 2020-10-18
    Jennifer M. Roscoe; Carolyn S. Sevier

    The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H2O2) and a hub for peroxide-based signaling events. Here we outline cellular sources of ER-localized peroxide, including sources within and near the ER. Focusing on three ER-localized proteins—the molecular chaperone BiP, the transmembrane stress-sensor IRE1, and the calcium pump SERCA2—we discuss how post-translational modification

    更新日期:2020-10-19
  • Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C
    Cells (IF 4.366) Pub Date : 2020-10-18
    Marius W. Baeken; Katja Weckmann; Philip Diefenthäler; Jan Schulte; Kamran Yusifli; Bernd Moosmann; Christian Behl; Parvana Hajieva

    Macroautophagy is a conserved degradative process for maintaining cellular homeostasis and plays a key role in aging and various human disorders. The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key marker for autophagosomes and as a proxy for autophagic flux. Three paralogues of the LC3 gene exist in humans: LC3A, LC3B and LC3C. The molecular function

    更新日期:2020-10-19
  • Crosstalk of Hedgehog and mTORC1 Pathways
    Cells (IF 4.366) Pub Date : 2020-10-18
    Lasse Jonsgaard Larsen; Lisbeth Birk Møller

    Hedgehog (Hh) signaling and mTOR signaling, essential for embryonic development and cellular metabolism, are both coordinated by the primary cilium. Observations from cancer cells strongly indicate crosstalk between Hh and mTOR signaling. This hypothesis is supported by several studies: Evidence points to a TGFβ-mediated crosstalk; Increased PI3K/AKT/mTOR activity leads to increased Hh signaling through

    更新日期:2020-10-19
  • The Role of Proteostasis Derailment in Cardiac Diseases
    Cells (IF 4.366) Pub Date : 2020-10-19
    Bianca J. J. M. Brundel

    The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing and changes in lifestyle. Prevailing theories about the mechanisms of cardiac disease onset feature the gradual derailment of cellular protein homeostasis (proteostasis) and loss of the protein quality control as central factors. In the heart, loss of protein

    更新日期:2020-10-19
  • The miRNA Profile in Non-Hodgkin’s Lymphoma Patients with Secondary Myelodysplasia
    Cells (IF 4.366) Pub Date : 2020-10-19
    Yuliya Andreevna Veryaskina; Sergei Evgenievich Titov; Igor Borisovich Kovynev; Tatiana Ivanovna Pospelova; Igor Fyodorovich Zhimulev

    Myelodysplastic syndromes are a group of clonal diseases of hematopoietic stem cells and are characterized by multilineage dysplasia, ineffective hematopoiesis, peripheral blood cytopenias, genetic instability and a risk of transformation to acute myeloid leukemia. Some patients with non-Hodgkin lymphomas (NHLs) may have developed secondary myelodysplasia before therapy. Bone marrow (BM) hematopoiesis

    更新日期:2020-10-19
  • Plant Cell Wall Changes in Common Wheat Roots as a Result of Their Interaction with Beneficial Fungi of Trichoderma
    Cells (IF 4.366) Pub Date : 2020-10-19
    Aneta Basińska-Barczak; Lidia Błaszczyk; Kinga Szentner

    Plant cell walls play an important role in shaping the defense strategies of plants. This research demonstrates the influence of two differentiators: the lifestyle and properties of the Trichoderma species on cell wall changes in common wheat seedlings. The methodologies used in this investigation include microscopy observations and immunodetection. In this study was shown that the plant cell wall

    更新日期:2020-10-19
  • Single Cell ADNP Predictive of Human Muscle Disorders: Mouse Knockdown Results in Muscle Wasting
    Cells (IF 4.366) Pub Date : 2020-10-19
    Oxana Kapitansky; Gidon Karmon; Shlomo Sragovich; Adva Hadar; Meishar Shahoha; Iman Jaljuli; Lior Bikovski; Eliezer Giladi; Robert Palovics; Tal Iram; Illana Gozes

    Activity-dependent neuroprotective protein (ADNP) mutations are linked with cognitive dysfunctions characterizing the autistic-like ADNP syndrome patients, who also suffer from delayed motor maturation. We thus hypothesized that ADNP is deregulated in versatile myopathies and that local ADNP muscle deficiency results in myopathy, treatable by the ADNP fragment NAP. Here, single-cell transcriptomics

    更新日期:2020-10-19
  • Epigenetics in Liver Fibrosis: Could HDACs Be a Therapeutic Target?
    Cells (IF 4.366) Pub Date : 2020-10-19
    Alex Claveria-Cabello; Leticia Colyn; Maria Arechederra; Jesus M. Urman; Carmen Berasain; Matias A Avila; Maite G Fernandez-Barrena

    Chronic liver diseases (CLD) represent a worldwide health problem. While CLDs may have diverse etiologies, a common pathogenic denominator is the presence of liver fibrosis. Cirrhosis, the end-stage of CLD, is characterized by extensive fibrosis and is markedly associated with the development of hepatocellular carcinoma. The most important event in hepatic fibrogenesis is the activation of hepatic

    更新日期:2020-10-19
  • Effects of Coronavirus Persistence on the Genome Structure and Subsequent Gene Expression, Pathogenicity and Adaptation Capability
    Cells (IF 4.366) Pub Date : 2020-10-19
    Ching-Hung Lin; Cheng-Yao Yang; Meilin Wang; Shan-Chia Ou; Chen-Yu Lo; Tsung-Lin Tsai; Hung-Yi Wu

    Coronaviruses are able to establish persistence. However, how coronaviruses react to persistence and whether the selected viruses have altered their characteristics remain unclear. In this study, we found that the persistent infection of bovine coronavirus (BCoV), which is in the same genus as SARS-COV-2, led to alterations of genome structure, attenuation of gene expression, and the synthesis of subgenomic

    更新日期:2020-10-19
  • Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity
    Cells (IF 4.366) Pub Date : 2020-10-19
    Anupriya Chatterjee; Rachana Eshwaran; Gernot Poschet; Santosh Lomada; Mahmoud Halawa; Kerstin Wilhelm; Martina Schmidt; Hans-Peter Hammes; Thomas Wieland; Yuxi Feng

    Our previous studies identified that retinal endothelial damage caused by hyperglycemia or nucleoside diphosphate kinase-B (NDPK-B) deficiency is linked to elevation of angiopoietin-2 (Ang-2) and the activation of the hexosamine biosynthesis pathway (HBP). Herein, we investigated how NDPK-B is involved in the HBP in endothelial cells (ECs). The activities of NDPK-B and O-GlcNAcase (OGA) were measured

    更新日期:2020-10-19
  • SRSF3 Is a Critical Requirement for Inclusion of Exon 3 of BIS Pre-mRNA
    Cells (IF 4.366) Pub Date : 2020-10-19
    Ji-Ye Baek; Hye-Hyeon Yun; Soon-Young Jung; Jeehan Lee; Kyunghyun Yoo; Jeong-Hwa Lee

    BCL-2 interacting cell death suppressor (BIS), also known as BAG3, is a multifunctional protein. Aberrant expression and mutation of BIS have been implicated in cancers and myopathy. However, there have only been a few studies on the splicing of BIS pre-mRNA. In the present study, through RT-PCR and sequencing in various cell lines and mouse tissues, we identified for the first time the presence of

    更新日期:2020-10-19
  • Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis
    Cells (IF 4.366) Pub Date : 2020-10-19
    Melissa Witzig; Amandine Grimm; Karen Schmitt; Imane Lejri; Stephan Frank; Steven A. Brown; Anne Eckert

    Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmission, learning and memory processes, and neuroprotection. Here, we show for the first time that mitochondrial neurosteroidogenesis follows a circadian

    更新日期:2020-10-19
  • GUN1 and Plastid RNA Metabolism: Learning from Genetics
    Cells (IF 4.366) Pub Date : 2020-10-16
    Luca Tadini; Nicolaj Jeran; Paolo Pesaresi

    GUN1 (genomes uncoupled 1), a chloroplast-localized pentatricopeptide repeat (PPR) protein with a C-terminal small mutS-related (SMR) domain, plays a central role in the retrograde communication of chloroplasts with the nucleus. This flow of information is required for the coordinated expression of plastid and nuclear genes, and it is essential for the correct development and functioning of chloroplasts

    更新日期:2020-10-17
  • Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets
    Cells (IF 4.366) Pub Date : 2020-10-16
    Jae Hyung Park; Woo Yang Pyun; Hyunwoo Henry Park

    Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, and cancer stem cells. Well-known oncogenic signaling pathways, such as phosphoinositide 3-kinase (PI3K)/AKT, Myc, and Hippo pathway, mediate metabolic gene expression and increase metabolic enzyme

    更新日期:2020-10-17
  • Insulin-Like Growth Factors in Development, Cancers and Aging
    Cells (IF 4.366) Pub Date : 2020-10-17
    Haim Werner

    Note: In lieu of an abstract, this is an excerpt from the first page. Since their discovery in the late 1950s, insulin-like growth factors (IGFs) have attracted significant interest in multiple areas of biology and medicine, including endocrinology, pediatrics, growth, metabolism, nutrition, aging, and oncology [...]

    更新日期:2020-10-17
  • Hyperleukocytosis and Leukostasis in Acute Myeloid Leukemia: Can a Better Understanding of the Underlying Molecular Pathophysiology Lead to Novel Treatments?
    Cells (IF 4.366) Pub Date : 2020-10-17
    Jan Philipp Bewersdorf; Amer M. Zeidan

    Up to 18% of patients with acute myeloid leukemia (AML) present with a white blood cell (WBC) count of greater than 100,000/µL, a condition that is frequently referred to as hyperleukocytosis. Hyperleukocytosis has been associated with an adverse prognosis and a higher incidence of life-threatening complications such as leukostasis, disseminated intravascular coagulation (DIC), and tumor lysis syndrome

    更新日期:2020-10-17
  • ER-to-Golgi Transport in HeLa Cells Displays High Resilience to Ca2+ and Energy Stresses
    Cells (IF 4.366) Pub Date : 2020-10-17
    Thomas Rauter; Sandra Burgstaller; Benjamin Gottschalk; Jeta Ramadani-Muja; Helmut Bischof; Jesse C. Hay; Wolfgang F. Graier; Roland Malli

    One third of all human proteins are either transmembrane or soluble secretory proteins that first target the endoplasmic reticulum (ER). These proteins subsequently leave the ER and enter the Golgi apparatus via ER-Golgi intermediate vesicular structures. Live-cell imaging of cargos fused to fluorescent proteins (FPs) enables the high-resolution visualization and characterization of secretory transport

    更新日期:2020-10-17
  • Anti-Müllerian Hormone Type II Receptor Expression in Endometrial Cancer Tissue
    Cells (IF 4.366) Pub Date : 2020-10-17
    Marek Gowkielewicz; Aleksandra Lipka; Marta Majewska; Aleksandra Piotrowska; Marta Szadurska-Noga; Jacek J. Nowakowski; Marta Wiszpolska; Piotr Dzięgiel; Tomasz Wasniewski; Mariusz Krzysztof Majewski; Marcin Jozwik

    Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts’ regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be considered as a potential therapeutic agent for cancer treatment. The purpose of this study

    更新日期:2020-10-17
  • Is It Meanwhile Biomedical Sciences or Still “Ars Medica”?
    Cells (IF 4.366) Pub Date : 2020-10-17
    Wolfgang H. Jost

    No abstract available

    更新日期:2020-10-17
  • Associations between Pregnane X Receptor and Breast Cancer Growth and Progression
    Cells (IF 4.366) Pub Date : 2020-10-15
    Bradley A. Creamer; Shelly N. B. Sloan; Jennifer F. Dennis; Robert Rogers; Sidney Spencer; Andrew McCuen; Purnadeo Persaud; Jeff L. Staudinger

    Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is responsive to a broad array of both endobiotic and xenobiotic ligands. PXR is involved in pivotal cellular detoxification processes to include the regulation of genes that encode key drug-metabolizing cytochrome-P450 enzymes, oxidative stress

    更新日期:2020-10-15
  • Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins
    Cells (IF 4.366) Pub Date : 2020-10-15
    Adriana Gutiérrez-Hoya; Isabel Soto-Cruz

    The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity. Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development. STAT proteins play an essential role in the development of cervical cancer

    更新日期:2020-10-15
  • PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice
    Cells (IF 4.366) Pub Date : 2020-10-15
    Maya Okamura; Ryota Shizu; Taiki Abe; Susumu Kodama; Takuomi Hosaka; Takamitsu Sasaki; Kouichi Yoshinari

    Pregnane X receptor (PXR) is a liver-enriched xenobiotic-responsive transcription factor. Although recent studies suggest that PXR shows anti-inflammatory effects by suppressing nuclear factor kappa B (NF-κB), the detailed mechanism remains unclear. In this study, we aimed to elucidate this mechanism. Mice were treated intraperitoneally with the PXR agonist pregnenolone 16α-carbonitrile (PCN) and/or

    更新日期:2020-10-15
  • Cannabinoid-Induced Autophagy and Heme Oxygenase-1 Determine the Fate of Adipose Tissue-Derived Mesenchymal Stem Cells under Stressful Conditions
    Cells (IF 4.366) Pub Date : 2020-10-15
    Katharina Bublitz; Sabine Böckmann; Kirsten Peters; Burkhard Hinz

    The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microenvironments. To identify protection strategies for ADMSCs, this study investigated

    更新日期:2020-10-15
  • Newborn Screening Samples for Diabetes Research: An Underused Resource
    Cells (IF 4.366) Pub Date : 2020-10-15
    Jane Frances Grace Lustre Estrella; Jincy Immanuel; Veronica Wiley; David Simmons

    Inborn errors of metabolism and diabetes share common derangements in analytes of metabolic networks that are tested for in newborn screening, usually performed 48–72 h after birth. There is limited research examining the metabolic imprint of diabetes on newborn screening results. This paper aims to demonstrate the links between diabetes, biochemical genetics and newborn screening in investigating

    更新日期:2020-10-15
  • How Altered Ribosome Production Can Cause or Contribute to Human Disease: The Spectrum of Ribosomopathies
    Cells (IF 4.366) Pub Date : 2020-10-15
    Giulia Venturi; Lorenzo Montanaro

    A number of different defects in the process of ribosome production can lead to a diversified spectrum of disorders that are collectively identified as ribosomopathies. The specific factors involved may either play a role only in ribosome biogenesis or have additional extra-ribosomal functions, making it difficult to ascribe the pathogenesis of the disease specifically to an altered ribosome biogenesis

    更新日期:2020-10-15
  • Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy
    Cells (IF 4.366) Pub Date : 2020-10-15
    Seth W. Streitmatter; Robert D. Stewart; Gregory Moffitt; Tatjana Jevremovic

    Accurate dosimetry and determination of the biological effectiveness of boron neutron capture therapy (BNCT) is challenging because of the mix of different types and energies of radiation at the cellular and subcellular levels. In this paper, we present a computational, multiscale system of models to better assess the relative biological effectiveness (RBE) and compound biological effectiveness (CBE)

    更新日期:2020-10-15
  • Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma
    Cells (IF 4.366) Pub Date : 2020-10-15
    Elena Parmigiani; Verdon Taylor; Claudio Giachino

    Although the role of NOTCH signaling has been extensively studied in health and disease, many questions still remain unresolved. Being crucial for tissue homeostasis, NOTCH signaling is also implicated in multiple cancers by either promoting or suppressing tumor development. In this review we illustrate the context-dependent role of NOTCH signaling during tumorigenesis with a particular focus on gliomas

    更新日期:2020-10-15
  • Mutual Interaction of Clinical Factors and Specific microRNAs to Predict Mild Cognitive Impairment in Patients Receiving Hemodialysis
    Cells (IF 4.366) Pub Date : 2020-10-15
    Jin-Bor Chen; Chiung-Chih Chang; Lung-Chih Li; Wen-Chin Lee; Chia-Ni Lin; Sung-Chou Li; Sin-Hua Moi; Cheng-Hong Yang

    Cognitive impairment (CI) is not uncommon in dialysis patients. Various factors have been implicated. This study aims to examine mutual interaction of various clinical factors for CI in patients receiving hemodialysis. A total of 48 hemodialysis patients in outpatient clinic were recruited from 2015 to 2017. Demographics, circulating uremic toxin concentrations, miRNA concentrations, and nerve injury

    更新日期:2020-10-15
  • Differences in Gating Dynamics of BK Channels in Cellular and Mitochondrial Membranes from Human Glioblastoma Cells Unraveled by Short- and Long-Range Correlations Analysis
    Cells (IF 4.366) Pub Date : 2020-10-15
    Agata Wawrzkiewicz-Jałowiecka; Paulina Trybek; Przemysław Borys; Beata Dworakowska; Łukasz Machura; Piotr Bednarczyk

    The large-conductance voltage- and Ca2+-activated K+ channels (BK) are encoded in humans by the Kcnma1 gene. Nevertheless, BK channel isoforms in different locations can exhibit functional heterogeneity mainly due to the alternative splicing during the Kcnma1 gene transcription. Here, we would like to examine the existence of dynamic diversity of BK channels from the inner mitochondrial and cellular

    更新日期:2020-10-15
  • Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
    Cells (IF 4.366) Pub Date : 2020-10-15
    Jenni Küblbeck; Jonna Niskanen; Paavo Honkakoski

    During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules. Recent studies indicate that CAR participates, together with other nuclear receptors (NRs) and transcription factors, in regulation of hepatic glucose

    更新日期:2020-10-15
  • The Multi-Omics Architecture of Juvenile Idiopathic Arthritis
    Cells (IF 4.366) Pub Date : 2020-10-15
    Xiaoyuan Hou; Huiqi Qu; Sipeng Zhang; Xiaohui Qi; Hakon Hakonarson; Qianghua Xia; Jin Li

    Juvenile idiopathic arthritis (JIA) is highly heterogeneous in terms of etiology and clinical presentation with ambiguity in JIA classification. The advance of high-throughput omics technologies in recent years has gained us significant knowledge about the molecular mechanisms of JIA. Besides a minor proportion of JIA cases as monogenic, most JIA cases are polygenic disease caused by autoimmune mechanisms

    更新日期:2020-10-15
  • Targeting DNA Repair, Cell Cycle, and Tumor Microenvironment in B Cell Lymphoma
    Cells (IF 4.366) Pub Date : 2020-10-14
    Paul J. Bröckelmann; Mathilde R. W. de Jong; Ron D. Jachimowicz

    The DNA double-strand break (DSB) is the most cytotoxic lesion and compromises genome stability. In an attempt to efficiently repair DSBs, cells activate ATM kinase, which orchestrates the DNA damage response (DDR) by activating cell cycle checkpoints and initiating DSB repair pathways. In physiological B cell development, however, programmed DSBs are generated as intermediates for effective immune

    更新日期:2020-10-14
  • Fast Differentiation of HepaRG Cells Allowing Hepatitis B and Delta Virus Infections
    Cells (IF 4.366) Pub Date : 2020-10-14
    Julie Lucifora; Maud Michelet; Anna Salvetti; David Durantel

    HepaRG cells are liver bipotent progenitors acquiring hepatocytes features when differentiated in the presence of dimethylsulfoxide (DMSO). Differentiated HepaRG (dHepaRG) are considered the best surrogate model to primary human hepatocytes (PHH) and are susceptible to several hepatotropic viruses, including Hepatitis B Virus (HBV) and Hepatitis Delta Virus (HDV) infection. Despite these advantages

    更新日期:2020-10-14
  • Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in Dictyostelium discoideum
    Cells (IF 4.366) Pub Date : 2020-10-14
    Sanjanie Fernando; Claire Y. Allan; Katelyn Mroczek; Xavier Pearce; Oana Sanislav; Paul R. Fisher; Sarah J. Annesley

    Alpha synuclein has been linked to both sporadic and familial forms of Parkinson’s disease (PD) and is the most abundant protein in Lewy bodies a hallmark of Parkinson’s disease. The function of this protein and the molecular mechanisms underlying its toxicity are still unclear, but many studies have suggested that the mechanism of α-synuclein toxicity involves alterations to mitochondrial function

    更新日期:2020-10-14
  • Re-Examining the Role of TNF in MS Pathogenesis and Therapy
    Cells (IF 4.366) Pub Date : 2020-10-14
    Diego Fresegna; Silvia Bullitta; Alessandra Musella; Francesca Romana Rizzo; Francesca De Vito; Livia Guadalupi; Silvia Caioli; Sara Balletta; Krizia Sanna; Ettore Dolcetti; Valentina Vanni; Antonio Bruno; Fabio Buttari; Mario Stampanoni Bassi; Georgia Mandolesi; Diego Centonze; Antonietta Gentile

    Multiple sclerosis (MS) is a common neurological disorder of putative autoimmune origin. Clinical and experimental studies delineate abnormal expression of specific cytokines over the course of the disease. One major cytokine that has been shown to play a pivotal role in MS is tumor necrosis factor (TNF). TNF is a pleiotropic cytokine regulating many physiological and pathological functions of both

    更新日期:2020-10-14
  • Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis
    Cells (IF 4.366) Pub Date : 2020-10-14
    Killian L’Herondelle; Matthieu Talagas; Olivier Mignen; Laurent Misery; Raphaele Le Garrec

    Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with potent neurotoxins called ciguatoxins (CTXs). Ciguatera is a complex clinical syndrome in which peripheral neurological signs predominate in the acute phase of the intoxication but also persist or reoccur long afterward. Their recognition is

    更新日期:2020-10-14
  • The Tumor Suppressive mir-148a Is Epigenetically Inactivated in Classical Hodgkin Lymphoma
    Cells (IF 4.366) Pub Date : 2020-10-14
    Julia Paczkowska; Joanna Janiszewska; Julia Bein; Markus Schneider; Kinga Bednarek; Adam Ustaszewski; Sylvia Hartmann; Martin-Leo Hansmann; Maciej Giefing

    DNA methylation was shown previously to be a crucial mechanism responsible for transcriptional deregulation in the pathogenesis of classical Hodgkin lymphoma (cHL). To identify epigenetically inactivated miRNAs in cHL, we have analyzed the set of miRNAs downregulated in cHL cell lines using bisulfite pyrosequencing. We focused on miRNAs with promoter regions located within or <1000 bp from a CpG island

    更新日期:2020-10-14
  • Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease
    Cells (IF 4.366) Pub Date : 2020-10-14
    Nur Farah Meor Azlan; Jinwei Zhang

    The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading. The CCCs play vital roles in cell volume regulation and ion homeostasis. The functions of CCCs influence a variety of physiological processes, many of which overlap with the

    更新日期:2020-10-14
  • The Role of Aryl-Hydrocarbon Receptor (AhR) in Osteoclast Differentiation and Function
    Cells (IF 4.366) Pub Date : 2020-10-14
    Robin Park; Shreya Madhavaram; Jong Dae Ji

    Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays a crucial role in bone remodeling through altering the interplay between bone-forming osteoblasts and bone-resorbing osteoclasts. While effects of AhR signaling in osteoblasts are well understood, the role and mechanism of AhR signaling in regulating osteoclastogenesis is not widely understood. AhR, when binding with

    更新日期:2020-10-14
  • The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders
    Cells (IF 4.366) Pub Date : 2020-10-13
    Paulina Pawelec; Malgorzata Ziemka-Nalecz; Joanna Sypecka; Teresa Zalewska

    Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is expressed in microglia. Within the CNS, fractalkine acts as a regulator of microglia activation in response to brain injury or inflammation. During the last decade, there has been a growing interest in the roles that the CX3CL1/CX3CR1

    更新日期:2020-10-13
  • mTOR Signaling in Metabolism and Cancer
    Cells (IF 4.366) Pub Date : 2020-10-13
    Shile Huang

    The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understanding of the mTOR pathway and its role in the regulation

    更新日期:2020-10-13
  • Rho Family of Ras-Like GTPases in Early-Branching Animals
    Cells (IF 4.366) Pub Date : 2020-10-13
    Silvestar Beljan; Maja Herak Bosnar; Helena Ćetković

    Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into

    更新日期:2020-10-13
  • IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension
    Cells (IF 4.366) Pub Date : 2020-10-13
    Siladitta Biswas; Baktybek Kojonazarov; Stefan Hadzic; Michael Majer; Ganimete Bajraktari; Tatyana Novoyatleva; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Werner Seeger; Norbert Weissmann; Jens Schlossmann; Ralph Theo Schermuly

    PKGs are serine/threonine kinases. PKG1 has two isoforms—PKG1α and β. Inositol trisphosphate receptor (IP3R)-associated cGMP-kinase substrate 1 (IRAG1) is a substrate for PKG1β. IRAG1 is also known to further interact with IP3RI, which mediates intracellular Ca2+ release. However, the role of IRAG1 in PH is not known. Herein, WT and IRAG1 KO mice were kept under normoxic or hypoxic (10% O2) conditions

    更新日期:2020-10-13
  • Aberrant DNA Methylation of ABC Transporters in Cancer
    Cells (IF 4.366) Pub Date : 2020-10-13
    Katja Zappe; Margit Cichna-Markl

    ATP-binding cassette (ABC) transporters play a crucial role in multidrug resistance (MDR) of cancers. They function as efflux pumps, resulting in limited effectiveness or even failure of therapy. Increasing evidence suggests that ABC transporters are also involved in tumor initiation, progression, and metastasis. Tumors frequently show multiple genetic and epigenetic abnormalities, including changes

    更新日期:2020-10-13
  • LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response
    Cells (IF 4.366) Pub Date : 2020-10-13
    Björn Koos; Eva Lotta Moderegger; Katharina Rump; Hartmuth Nowak; Katrin Willemsen; Caroline Holtkamp; Patrick Thon; Michael Adamzik; Tim Rahmel

    Mitochondrial DNA (mtDNA) plays a vital role as a damage-associated molecular pattern in sepsis being able to shape the immune response. Since pathogen recognition receptors of innate immune cells are activated by demethylated DNA only, we set out to investigate the amount of DNA methyltransferase 1 (DNMT1) in mitochondria and the extent of mtDNA methylation in a human endotoxin model. Peripheral blood

    更新日期:2020-10-13
  • Gut Microbiome Changes in Patients with Active Left-sided Ulcerative Colitis after Fecal Microbiome Transplantation and Topical 5-aminosalicylic Acid Therapy
    Cells (IF 4.366) Pub Date : 2020-10-13
    Dagmar Schierová; Jan Březina; Jakub Mrázek; Kateřina Olša Fliegerová; Simona Kvasnová; Lukáš Bajer; Pavel Drastich

    Ulcerative colitis (UC) is an inflammatory bowel disease, and intestinal bacteria are implicated in the pathogenesis of this disorder. The administration of aminosalicylates (5-ASA) is a conventional treatment that targets the mucosa, while fecal microbial transplantation (FMT) is a novel treatment that directly targets the gut microbiota. The aim of this study was to identify changes in fecal bacterial

    更新日期:2020-10-13
  • Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms
    Cells (IF 4.366) Pub Date : 2020-10-13
    Jinkyung Cho; Youngju Choi; Pavol Sajgalik; Mi-Hyun No; Sang-Hyun Lee; Sujin Kim; Jun-Won Heo; Eun-Jeong Cho; Eunwook Chang; Ju-Hee Kang; Hyo-Bum Kwak; Dong-Ho Park

    Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), which is a dominant pathogenesis in the aging heart. HF causes diverse metabolic complications that may

    更新日期:2020-10-13
  • The Effects of Divalent Cation-Chelated Prion Fibrils on the Immune Response of EOC 13.31 Microglia Cells
    Cells (IF 4.366) Pub Date : 2020-10-13
    Huan-I Jen; Zih-You Lin; Jin-Xun Guo; Cheng-I Lee

    Transmissible spongiform encephalopathies (TSEs) are epidemic neurodegenerative diseases caused by prion proteins; in particular, they are induced by misfolded prion proteins (PrPSc). PrPSc tend to aggregate into insoluble amyloid prion fibrils (fPrPWT), resulting in apoptosis of neuron cells and sequential neurodegeneration. Previous studies indicate that microglia cells play an important role in

    更新日期:2020-10-13
  • Modulation of Inflammasome and Pyroptosis by Olaparib, a PARP-1 Inhibitor, in the R6/2 Mouse Model of Huntington’s Disease
    Cells (IF 4.366) Pub Date : 2020-10-13
    Emanuela Paldino; Vincenza D’Angelo; Daunia Laurenti; Cecilia Angeloni; Giuseppe Sancesario; Francesca R. Fusco

    Pyroptosis is a type of cell death that is caspase-1 (Casp-1) dependent, which leads to a rapid cell lysis, and it is linked to the inflammasome. We recently showed that pyroptotic cell death occurs in Huntington’s disease (HD). Moreover, we previously described the beneficial effects of a PARP-1 inhibitor in HD. In this study, we investigated the neuroprotective effect of Olaparib, an inhibitor of

    更新日期:2020-10-13
  • K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity
    Cells (IF 4.366) Pub Date : 2020-10-12
    Jimena Canales; Pablo Cruz; Nicolás Díaz; Denise Riquelme; Elías Leiva-Salcedo; Oscar Cerda

    Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and Ca2+ signaling. Interestingly, ubiquitination events have emerged as regulatory elements of migration. Thus, the role of proteins involved in ubiquitination processes could be relevant to a complete understanding of pro-migratory

    更新日期:2020-10-12
  • Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview
    Cells (IF 4.366) Pub Date : 2020-10-12
    Stephen John Yarwood

    The cyclic nucleotides 3′,5′-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man. Cyclic AMP is synthesised by adenylate cyclase (AC) enzymes in order to activate effector proteins and it is then degraded by phosphodiesterase (PDE) enzymes. Research in recent years has identified a range of cell-type-specific cyclic AMP

    更新日期:2020-10-12
  • Age-Dependent Maturation of iPSC-CMs Leads to the Enhanced Compartmentation of β2AR-cAMP Signalling
    Cells (IF 4.366) Pub Date : 2020-10-12
    Alveera Hasan; Neda Mohammadi; Aisha Nawaz; Thusharika Kodagoda; Ivan Diakonov; Sian E. Harding; Julia Gorelik

    The ability to differentiate induced-pluripotent stem cells into cardiomyocytes (iPSC-CMs) has opened up novel avenues for potential cardiac therapies. However, iPSC-CMs exhibit a range of somewhat immature functional properties. This study explored the development of the beta-adrenergic receptor (βAR) pathway, which is crucial in regulating contraction and signifying the health and maturity of myocytes

    更新日期:2020-10-12
  • Understanding IGF-II Action through Insights into Receptor Binding and Activation
    Cells (IF 4.366) Pub Date : 2020-10-12
    Andrew J. Blyth; Nicholas S. Kirk; Briony E. Forbes

    The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and is especially important during fetal growth and development. IGF-II is also found to be overexpressed in several cancer types, promoting growth and

    更新日期:2020-10-12
  • Pseudomonas aeruginosa Planktonic- and Biofilm-Conditioned Media Elicit Discrete Metabolic Responses in Human Macrophages
    Cells (IF 4.366) Pub Date : 2020-10-09
    Amanda L. Fuchs; Isaac R. Miller; Sage M. Schiller; Mary Cloud B. Ammons; Brian Eilers; Brian Tripet; Valérie Copié

    Macrophages (MΦs) are prevalent innate immune cells, present throughout human bodily tissues where they orchestrate innate and adaptive immune responses to maintain cellular homeostasis. MΦs have the capacity to display a wide array of functional phenotypes due to different microenvironmental cues, particularly soluble bacterial secretory products. Recent evidence has emerged demonstrating that metabolism

    更新日期:2020-10-11
  • Astrogliosis in an Experimental Model of Hypovitaminosis B12: A Cellular Basis of Neurological Disorders due to Cobalamin Deficiency
    Cells (IF 4.366) Pub Date : 2020-10-09
    Zuzanna Rzepka; Jakub Rok; Justyna Kowalska; Klaudia Banach; Justyna Magdalena Hermanowicz; Artur Beberok; Beata Sieklucka; Dorota Gryko; Dorota Wrześniok

    Cobalamin deficiency affects human physiology with sequelae ranging from mild fatigue to severe neuropsychiatric abnormalities. The cellular and molecular aspects of the nervous system disorders associated with hypovitaminosis B12 remain largely unknown. Growing evidence indicates that astrogliosis is an underlying component of a wide range of neuropathologies. Previously, we developed an in vitro

    更新日期:2020-10-11
  • The Functional Role of microRNAs in the Pathogenesis of Tauopathy
    Cells (IF 4.366) Pub Date : 2020-10-09
    Domenico Praticò

    Tauopathies are neurodegenerative disorders which include Alzheimer’s disease, Pick’s disease, corticobasal degeneration, and progressive supranuclear palsy among others. Pathologically, they are characterized by the accumulation of highly phosphorylated and aggregated tau protein in different brain regions. Currently, the mechanisms responsible for their pathogenesis are not known, and for this reason

    更新日期:2020-10-11
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>