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Aglycemia induces apoptosis under hypoxic conditions in A549 cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-17 Yüksel Öğünç Keçeci, Zerrin İncesu
Many of the cancer cells produce energy with accelerated glycolysis and perform lactic acid production even under normoxic conditions called the “Warburg effect”. Metabolism can directly or indirectly regulate the apoptotic mechanism so that cancer cells take advantage of reprogrammed metabolism to avoid apoptosis. The aim of this study is to examine the mechanism of apoptosis by incubating human lung
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Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Mohammad Saleh Hasani Jebelli, Amir Yari, Nariman Nikparto, Sahar Cheperli, Amirali Asadi, Amirmohammad Arabi Darehdor, Sayna Nezaminia, Dorara Dortaj, Saeed Hasani Mehraban, Lotfollah Kamali Hakim
The demand for efficient and accelerated osseointegration in dental implantology has led to the exploration of innovative tissue engineering strategies. Immediate implant loading reduces treatment duration and necessitates robust osseointegration to ensure long‐term implant success. This review article discusses the current studies of tissue engineering innovations for enhancing osseointegration in
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Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Mohamed J. Saadh, Asma'a H. Mohamed, Muhammad Ali Abdullah Almoyad, Omer Qutaiba B. Allela, Ali H. Amin, April Ann Malquisto, Wong Tze Jin, Ioan Sârbu, Faisal AlShamsi, Fahmy Gad Elsaid, Reza Akhavan‐Sigari
Colorectal cancer (CRC) is one of the main causes of cancer‐related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer‐related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through
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Attenuation of cannabis withdrawal symptoms by Prosopis farcta extract, its luteolin and melatonin in mice: Involvement of brain‐derived neurotrophic factor and dopamine Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Javad Ghasemian‐Yadegari, Ahmad Adineh, Hamidreza Mohammadi, Shima Davari, Yousef Veisani, Hori Ghaneialvar, Ali Aidy, Naser Abbasi, Elahe Karimi
The aim of this study was the identification of luteolin in Prosopis farcta extract (PFE) and melatonin to evaluate its effect on THC withdrawal syndrome in mice. Luteolin was identified by high‐performance liquid chromatography (HPCL). Signs of toxicity of mice in PFE and luteolin were monitored for LD50 calculation. The behavioral symptoms of THC withdrawal (stereotypies, ambulation, and inactivity
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Betaine postpones hyperglycemia‐related senescence in ovarian and testicular cells: Involvement of RAGE and β‐galactosidase Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Neda Mohammadi, Mina Hemmati, Behrouz Motlagh, Arezou Biyabani
The structural and functional disorders of the testis and ovary are one of the main complications of hyperglycemia. Betaine is a trimethyl glycine with antioxidant, antidiabetic, and anti‐inflammatory potential. The aim of this study is to investigate the potential of betaine on the expression of aging and oxidative stress markers in ovarian and testicular cells under hyperglycemic conditions. Testicular
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Adaptive responses of the ileum of NOD mice to low‐dose fluoride: A proteomic exploratory study Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Juliana S. Trevizol, Nathalia R. Buzalaf, Aline Dionizio, Aislan Q. Delgado, João P. Z. de Lara, Ana C. Magalhães, José R. Bosqueiro, Marília A. R. Buzalaf
Fluoride (F) has been employed worldwide to control dental caries. More recently, it has been suggested that the consumption of low doses of F in the drinking water may reduce blood glucose levels, introducing a new perspective for the use of F for the management of blood glucose. However, the exact mechanism by which F affects blood glucose levels remains largely unexplored. Given that the small gut
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Goat mammary epithelial cells provide a better expression system for production of recombinant human bone morphogenetic protein 2 compared to Chinese hamster ovarian cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Venkateswaran Ganesan, Goutam Ulgekar, Anandhi Ramalingam, Souvik Sen Sharma, Nirmalya Ganguli, Subeer S. Majumdar
Bone Morphogenetic Protein 2 (BMP2), a member of the Transforming Growth Factor‐β (TGF‐β) super family of proteins and is instrumental in the repair of fractures. The synthesis of BMP2 involves extensive post‐translational processing and several studies have demonstrated the abysmally low production of rhBMP2 in eukaryotic systems, which may be due to the short half‐life of the bioactive protein. Consequently
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Multifaceted impact of adipose conditioned media: Obesity‐driven promotion of prostate cancer and cancer stem cell dynamics Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-14 Suat Erdogan, Riza Serttas, Ilker Dibirdik, Kader Turkekul
Obesity is an established risk factor for the development and progression of prostate cancer (PC). This study used adipose conditioned media (ACM) from differentiated adipocytes to assess its effect on PC development and aggressiveness. Due to limited research on ACM's impact on isolated PC stem cells (PCSCs), we also examined CD44+ PCSCs. ACM notably boosted interleukin‐1β (IL‐1β), IL‐6, and IL‐8
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A comprehensive review on potential drug–drug interactions of proton pump inhibitors with antidiabetic drugs metformin and DPP‐4 inhibitors Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-14 Jarin Tasnim, Najihah Mohd Hashim, Heh Choon Han
A drug interaction is a condition in which two or more drugs are taken at the same time. Type 2 diabetes mellitus is a significant contributor to polypharmacy. Proton pump inhibitors (PPIs) are often prescribed in combination with metformin or DPP‐4 inhibitors (sitagliptin, saxagliptin, linagliptin, and alogliptin) or a combined dose of metformin and DPP‐4 inhibitor to treat gastritis in diabetic patients
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Regulation and mechanism of organic selenium on quorum sensing, biofilm, and antioxidant effects of Lactobacillus paracasei Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-13 Zaixiang Lou, Jiale Dong, Hongwei Tao, Yeexuan Tan, Hongxin Wang
Different organic compounds can have varying degrees of impact on the activity of Lactobacillus paracasei. The study focused on the impact and action mechanism of different organic selenium products on the bioactivity of two strains of L. paracasei. The growth, antioxidant activity, extracellular polysaccharide secretion, quorum sensing (QS), and biofilm formation of the strains before and after the
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Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-12 Raed Obaid Saleh, Ali A. Majeed, Ria Margiana, Ola Kamal A. Alkadir, Sami G. Almalki, Pallavi Ghildiyal, Vadim Samusenkov, Noura Kareem Jabber, Yasser Fakri Mustafa, Ahmed Elawady
Cerebral ischemic damage is prevalent and the second highest cause of death globally across patient populations; it is as a substantial reason of morbidity and mortality. Mesenchymal stromal cells (MSCs) have garnered significant interest as a potential treatment for cerebral ischemic damage, as shown in ischemic stroke, because of their potent intrinsic features, which include self‐regeneration, immunomodulation
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Cells in the liver microenvironment regulate the process of liver metastasis Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-09 Pei Wang, Yu Jie, Lin Yao, Yi‐meng Sun, Da‐peng Jiang, Shi‐qi Zhang, Xiao‐yan Wang, Yu Fan
The research of liver metastasis is a developing field. The ability of tumor cells to invade the liver depends on the complicated interactions between metastatic cells and local subpopulations in the liver (including Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells, and immune‐related cells). These interactions are mainly mediated by intercellular adhesion and the release of
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Exploring the emerging bidirectional association between inflamm‐aging and cellular senescence in organismal aging and disease Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-08 Rohit Sharma
There is strong evidence that most individuals in the elderly population are characterized by inflamm‐aging which refers to a subtle increase in the systemic pro‐inflammatory environment and impaired innate immune activation. Although a variety of distinct factors are associated with the progression of inflamm‐aging, emerging research is demonstrating a dynamic relationship between the processes of
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Reduction characteristic of chlorobenzene by a newly isolated Paenarthrobacter ureafaciens LY from a pharmaceutical wastewater treatment plant Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-08 Nan Liu, Yan‐yan Yao, Jin Zhang, Ji‐guo Zhang, Chao Wu, Du‐juan Ouyang, Chang‐yong Zou, Zhen‐qiang Yang, Ji‐xiang Li
A highly efficient chlorobenzene‐degrading strain was isolated from the sludge of a sewage treatment plant associated with a pharmaceutical company. The strain exhibited a similarity of over 99.9% with multiple strains of Paenarthrobacter ureafaciens. Therefore, the strain was suggested to be P. ureafaciens LY. This novel strain exhibited a broad spectrum of pollutant degradation capabilities, effectively
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The role and molecular mechanism of NOP16 in the pathogenesis of nasopharyngeal carcinoma Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-08 Wenmin Xiong, Daojing Li, Fenghua Ao, Ziwei Tu, Jianping Xiong
We aimed to explore the effects of NOP16 on the pathogenesis of nasopharyngeal carcinoma (NPC) and the related mechanism. In this study, the expression level of NOP16 in NPC tissues and adjacent tissues was measured by qRT‐polymerase chain reaction (PCR) and immunohistochemistry (IHC) tests. In the in vitro study, the expression levels of NOP16 and RhoA/phosphatidylinositol 3‐kinase (PI3K)/Akt/c‐Myc
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Characterization of two bacteriophages specific to Acinetobacter baumannii and their effects on catheters biofilm Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-06 Hilal Basak Erol, Banu Kaskatepe, Sulhiye Yildiz, Nurten Altanlar, Fatma Bayrakdar
Multidrug‐resistant strains of Acinetobacter baumannii cause major nosocomial infections. Bacteriophages that are specific to the bacterial species and destroy bacteria can be effectively used for treatment. In this study, we characterized lytic bacteriophages specific to A. baumannii strains. We isolated lytic bacteriophages from environmental water samples and then investigated their morphology,
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The role of ncRNAs‐mediated pyroptosis in diabetes and its vascular complications Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-05 Xinyao Feng, Xiaoxu Yang, Yancheng Zhong, Xihua Cheng
Over the past decade, the prevalence of diabetes has increased significantly worldwide, leading to an increase in vascular complications of diabetes (VCD), such as diabetic cardiomyopathy (DCM), diabetic nephropathy (DN), and diabetic retinopathy (DR). Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), long Noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), play a key role in cellular processes
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Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-05 Amir Mohammad Nezhad Salari, Zahra Rasoulizadeh, Arezoo Gowhari Shabgah, Roghayyeh Vakili‐Ghartavol, Ghasem Sargazi, Jamshid Gholizadeh Navashenaq
Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, has garnered increasing attention due to its potential neuroprotective effects in neurological diseases. This research examines the existing literature concerning the involvement of kaempferol in neurological diseases, including stroke, Parkinson's disease, Alzheimer's disease, neuroblastoma/glioblastoma, spinal
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Leukemia cancer cells and immune cells derived‐exosomes: Possible roles in leukemia progression and therapy Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-01 Dyar Mudhafar Salman, Talar Ahmad Merza Mohammad
Exosomes have a significant impact on tumor survival, proliferation, metastasis, and recurrence. They also open up new therapeutic options and aid in the pathological identification and diagnosis of cancers. Exosomes have been shown in numerous studies to be essential for facilitating cell‐to‐cell communication. In B‐cell hematological malignancies, the proteins and RNAs that are encased by circulating
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The role of lncRNA HCG18 in human diseases Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-01 Feng Long, Xuan Zhou, Jinhua Zhang, Cuixia Di, Xue Li, Hailin Ye, Jingyu Pan, Jing Si
A substantial number of long noncoding RNAs (lncRNAs) have been identified as potent regulators of human disease. Human leukocyte antigen complex group 18 (HCG18) is a new type of lncRNA that has recently been proven to play an important role in the occurrence and development of various diseases. Studies have found that abnormal expression of HCG18 is closely related to the clinicopathological characteristics
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Fullertubes inhibit mycobacterial viability and prevent biofilm formation by disrupting the cell wall Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-01 Varun Shenoy, Rashmika Gunda, Cora Noble, Annalisa Haraguchi, Steven Stevenson, Jaiyanth Daniel
Mycobacterium tuberculosis and nontuberculous mycobacteria such as Mycobacterium abscessus cause diseases that are becoming increasingly difficult to treat due to emerging antibiotic resistance. The development of new antimicrobial molecules is vital for combating these pathogens. Carbon nanomaterials (CNMs) are a class of carbon‐containing nanoparticles with promising antimicrobial effects. Fullertubes
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Modulating the acetylation of α‐tubulin by LncRNAs and microRNAs helps in the progression of cancer Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-28 Sneha Kar, Rimi Mukherjee, Subhabrata Guha, Debojit Talukdar, Gaurav Das, Nabendu Murmu
Malignant tumor cells go through morphological and gene expression alterations, including rearrangement of cytoskeleton proteins that promote invasion and metastasis. Microtubules form a major cytoskeleton component that plays a significant role in regulating multiple cellular activities and function depending on the presence of posttranslational modification (PTM). Acetylation is a type of PTM that
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Recent advances in mRNA‐based vaccine for cancer therapy; bench to bedside Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-26 Hadeel Ahmed Kenoosh, Harikumar Pallathadka, Ahmed Hjazi, Aiman Mohammed Baqir Al‐Dhalimy, Sajad Ali Zearah, Pallavi Ghildiyal, Zuhair I. Al‐Mashhadani, Yasser Fakri Mustafa, Manar Mohammed Hizam, Ahmed Elawady
The messenger RNA (mRNA) vaccines have progressed from a theoretical concept to a clinical reality over the last few decades. Compared to conventional vaccination methods, these vaccines have a number of benefits, such as substantial potency, rapid growth, inexpensive production, and safe administration. Nevertheless, their usefulness was restricted up to now due to worries about the erratic and ineffective
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Pterostilbene protects against H2O2‐induced oxidative stress by regulating GAS6/Axl signaling in HL‐1 cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-26 Wencheng Di, Aizhen Zhao, Xiaoru Li, Junmin Chen, Yongbin Dai, Jiawen Li, Wangrui Lei, Yang Yang, Hongzhou Lu
Pterostilbene (PTE, trans‐3,5‐dimethoxy‐4′‐hydroxystilbene), a natural plant polyphenol, possesses numerous pharmacological effects, including antioxidant, antidiabetic, antiatherosclerotic, and neuroprotective aspects. This study aims to investigate whether PTE plays a protective role against oxidative stress injury by GAS6/Axl signaling pathway in cardiomyocytes. Hydrogen peroxide (H2O2)‐induced
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Acetylated oligopeptide and N‐acetylcysteine protect against iron overload‐induced dentate gyrus hippocampal degeneration through upregulation of Nestin and Nrf2/HO‐1 and downregulation of MMP‐9/TIMP‐1 and GFAP Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-24 Amira A. Kamel, Ahmed Y. Nassar, Fatma Y. Meligy, Yomna A. Omar, Gamal A. Y. Nassar, Ghada M. Ezzat
Iron accumulation in the brain causes oxidative stress, blood–brain barrier (BBB) breakdown, and neurodegeneration. We examined the preventive effects of acetylated oligopeptides (AOP) from whey protein on iron‐induced hippocampal damage compared to N‐acetyl cysteine (NAC). This 5‐week study used 40 male albino rats. At the start, all rats received 150 mg/kg/day of oral NAC for a week. The 40 animals
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Kurarinone targets JAK2‐STAT3 signaling in colon cancer‐stem‐like cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-23 Kumari Sunita Prajapati, Shashank Kumar
Natural compounds are known to regulate stemness/self‐renewal properties in colon cancer cells at molecular level. In the present study, we first time studied the colon cancer stem‐like cells targeting potential of Kurarinone (KU) and explored the underlying mechanism. Cytotoxic potential of KU was checked in colon cancer cells. Colonosphere formation assay was performed to check the spheroid formation
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CAR‐T cell therapeutic avenue for fighting cardiac fibrosis: Roadblocks and perspectives Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-21 Ahmed M. E. Abdalla, Yu Miao, Ahmed I. M. Ahmed, Ning Meng, Chenxi Ouyang
Heart diseases remain the primary cause of human mortality in the world. Although conventional therapeutic opportunities fail to halt or recover cardiac fibrosis, the promising clinical results and therapeutic efficacy of engineered chimeric antigen receptor (CAR) T cell therapy show several advancements. However, the current models of CAR‐T cells need further improvement since the T cells are associated
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Integrative ATAC‐seq and RNA‐seq analysis associated with diabetic nephropathy and identification of novel targets for treatment by dapagliflozin Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-21 Jianxiao Shen, Liang Ying, Jiajia Wu, Yan Fang, Wenyan Zhou, Chaojun Qi, Leyi Gu, Shan Mou, Yuru Yan, Ming Tian, Zhaohui Ni, Xiajing Che
Dapagliflozin (DAPA) are clinically effective in improving diabetic nephropathy (DN). However, whether and how chromatin accessibility changed by DN responds to DAPA treatment is unclear. Therefore, we performed ATAC‐seq, RNA‐seq, and weighted gene correlation network analysis to identify the chromatin accessibility, the messenger RNA (mRNA) expression, and the correlation between clinical phenotypes
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Regulatory role of miRNAs in nasopharyngeal cancer involving PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β-catenin and pRB-E2F signaling pathways: A review Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-16 Rabiatul Basria S. M. N. Mydin, Adam Azlan, Simon I. Okekpa, Nigel J. Gooderham
MicroRNAs (miRNA) are small and conserved noncoding RNA molecules that regulate gene expression at the posttranscriptional level. These groups of RNAs are crucial in various cellular processes, especially in mediating disease pathogenesis, particularly cancer. The dysregulation of miRNAs was reported in many cancer types, including nasopharyngeal cancer (NPC), which is a malignant tumor of the nasopharynx
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Caspase-driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-13 Meghana Allani, Akhilesh, Vinod Tiwari
Apoptosis is the cell's natural intrinsic regulatory mechanism of normal cells for programmed cell death, which plays an important role in cancer as a classical mechanism of tumor cell death causing minimal inflammation without causing damage to other cells in the vicinity. Induction of apoptosis by activation of caspases is one of the primary targets for cancer treatment. Over the years, a diverse
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Decoding the synergistic potential of MAZ-51 and zingerone as therapy for melanoma treatment in alignment with sustainable development goals Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-13 Kganya Letsoalo, Evangeline Nortje, Sean Patrick, Trevor Nyakudya, Yvette Hlophe
Melanoma, an invasive class of skin cancer, originates from mutations in melanocytes, the pigment-producing cells. Globally, approximately 132,000 new cases are reported each year, and in South Africa, the incidence stands at 2.7 per 100,000 people, signifying a worrisome surge in melanoma rates. Therefore, there is a need to explore treatment modalities that will target melanoma's signalling pathways
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The effect of photobiomodulation therapy in common maxillofacial injuries: Current status Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-13 Mostafa Alam, Shahryar Karami, Meysam Mohammadikhah, Ashkan Badkoobeh, Mohsen Golkar, Kamyar Abbasi, Reza Sayyad Soufdoost, Lotfollah Kamali Hakim, Sahar Talebi, Reza Abdollahi Namanloo, Ahmed Hussain, Artak Heboyan, Hamid Tebyaniyan
The use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. The effects of PBMT on maxillofacial injuries were discussed in this review article. The electronic databases Pubmed, Scopus, and Web of Science were thoroughly searched. This review included in vitro, in vivo, and clinical studies describing how PBMT can be used in maxillofacial tissue engineering
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Downregulated circRNA_CDKN1A promotes gallbladder cancer progression through activation of the NF-κB pathway Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-11 Bin Hu, Hui Yang, Yan Wang, Yi Cao, Rongping Zhou, Dong Yang
This study uncovered the potential clinical value and molecular driving mechanisms of circular RNAs (circRNAs) in gallbladder cancer (GBC). Differentially expressed circRNAs in GBC cells were screened by high-throughput sequencing. CircRNA_CDKN1A (circBase ID: hsa_circ_0076194) was knocked out in BGC-SD cells through transfection with sh-circRNA_CDKN1A. Then, proliferation was investigated via CCK8
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Effect of genistein and coenzyme Q10 in oxidative damage and mitochondrial membrane potential in an attenuated type II mucopolysaccharidosis cellular model Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-08 Camila Aguilar Delgado, Edina Poletto, Luisa Natalia Pimentel Vera, Carlos Eduardo Diaz Jacques, Priscila Vianna, Luiza Steffens Reinhardt, Guilherme Baldo, Carmen Regla Vargas
Mucopolysaccharidosis type II (MPS II) is an inborn error of the metabolism resulting from several possible mutations in the gene coding for iduronate-2-sulfatase (IDS), which leads to a great clinical heterogeneity presented by these patients. Many studies demonstrate the involvement of oxidative stress in the pathogenesis of inborn errors of metabolism, and mitochondrial dysfunction and oxidative
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Conjugated linoleic acid (CLA) reduces HFD-induced obesity by enhancing BAT thermogenesis and iWAT browning via the CD36–AMPK pathway Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-08 Fenglin Zhang, Yiming Fu, Junfeng Wang, Fan Li, Limin Lang, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Canjun Zhu, Qingyan Jiang, Songbo Wang
The antiobesity effect of conjugated linoleic acid (CLA) has been reported. However, the underlying mechanisms have not been fully clarified. Thus, this study aimed to investigate the effects of CLA on thermogenesis of interscapular brown adipose tissue (iBAT) and browning of inguinal subcutaneous white adipose tissue (iWAT) and explore the possible signaling pathway. The in vivo results showed that
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PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3 Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-07 Shougang Liu, Fanghua Liu, Zeqiao Zhang, Zhe Zhuang, Yongfeng Chen
Psoriasis is a recurrent and protracted disease that severely impacts the patient's physical and mental health. Thus, there is an urgent need to explore its pathogenesis to identify therapeutic targets. The expression level of protein tyrosine phosphatase nonreceptor type 2 (PTPN2) was analyzed by immunohistochemistry techniques in psoriatic tissues and imiquimod-induced psoriatic mouse models. PTPN2
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Andrographolide reverts multidrug resistance in KBChR 8-5 cells through AKT signaling pathway Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-07 Deepa S. Lakra, Pradhapsingh Bharathiraja, T. Dhanalakshmi, N. Rajendra Prasad
Multidrug resistance (MDR) is a major obstacle in cancer chemotherapy. P-glycoprotein (P-gp) one of the ATP-binding cassette (ABC) transporters plays an important role in MDR. In this study, we examined the sensitizing property of andrographolide (Andro) to reverse MDR in the drug-resistant KBChR 8-5 cells. Andro exhibited increased cytotoxicity in a concentration-dependent manner in the P-gp overexpressing
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The role of long noncoding RNA DGCR5 in cancers: Focus on molecular targets Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-07 Sulieman I. S. Al-Hawary, Paul Rodrigues, Harun Bangali, Zahraa F. Hassan, Ahmed Elawady
Long noncoding RNAs (lncRNAs) are major components of cellular transcripts that are emerging as important players in various biological pathways. Due to their specific expression and functional diversity in a variety of cancers, lncRNAs have promising applications in cancer diagnosis, prognosis, and therapy. Studies have shown that lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) with high specificity
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The connection between epigenetics and gut microbiota-current perspective Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-30 Xingxing Yuan, Yurong Tan, Ousman Bajinka, Modou L. Jammeh, Abubakarr Dukureh, Chidera N. Obiegbusi, Khalid A. Abdelhalim, Mahmoud Mohanad
Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in establishing effective diagnostics and potential therapeutic strategies for a number of diseases. These disorders include metabolic, central nervous system-related diseases, autoimmune, and gastrointestinal infections (GI). Despite the number of studies, there is no extensive review that connects the epigenetics
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The exo-microRNA (miRNA) signaling pathways in pathogenesis and treatment of stroke diseases: Emphasize on mesenchymal stem cells (MSCs) Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-01 Yalda Farahmand, Mohsen Nabiuni, Mahsa Vafaei Mastanabad, Mehrnaz Sheibani, Bashar Shaker Mahmood, Ali Mohammed Obayes, Fatemeh Asadi, Rosa Davallou
A major factor in long-term impairment is stroke. Patients with persistent stroke and severe functional disabilities have few therapy choices. Long noncoding RNAs (lncRNAs) may contribute to the regulation of the pathophysiologic processes of ischemic stroke as shown by altered expression of lncRNAs and microRNA (miRNAs) in blood samples of acute ischemic stroke patients. On the other hand, multipotent
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Temporal and differential proteomic profile of molecular mediators associated with chronic and acute wound healing Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-02-02 Midhat Batool Zaidi, Faisal Khan, Fatima Jameel, Irfan Khan, Syed Ghulam Musharraf, Asmat Salim
The underlying pathophysiology of nonhealing chronic wounds is poorly understood due to the changes occurring at the gene level and the complexity arising in their proteomic profile. Here, we elucidated the temporal and differential profile of the normal and diabetic wound-healing mediators along with their interactions and associated pathways. Skin tissues corresponding to normal and diabetic wounds
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miR-142-3p/5p role in cancer: From epigenetic regulation to immunomodulation Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-30 Parisa Zareifar, Hani Moslem Ahmed, Pouya Ghaderi, Yalda Farahmand, Negin Rahnama, Romina Esbati, Ali Moradi, Omid Yazdani, Yasin Sadeghipour
MicroRNAs (miRNAs) play critical roles in cancer pathobiology, acting as regulators of gene expression and pivotal drivers of tumorigenesis. It is believed that miRNAs act through canonical mechanisms, involving the binding of mature miRNAs to target messenger RNAs (mRNAs) and subsequent repression of protein translation or degradation of target mRNAs. miR-142-3p/5p has been extensively studied and
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Discovering the strength of immunometabolism in cancer therapy: Employing metabolic pathways to enhance immune responses Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-28 Huldani Huldani, Jitendra Malviya, Paul Rodrigues, Ahmed Hjazi, Maha Medha Deorari, Hussein Riyadh Abdul Kareem Al-Hetty, Qutaiba A. Qasim, Mohammed Qasim Alasheqi, Ali Ihsan
Immunometabolism, which studies cellular metabolism and immune cell function, is a possible cancer treatment. Metabolic pathways regulate immune cell activation, differentiation, and effector functions, crucial to tumor identification and elimination. Immune evasion and tumor growth can result from tumor microenvironment metabolic dysregulation. These metabolic pathways can boost antitumor immunity
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Hypoxia and its effect on the cellular system Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-27 Dipali Rahane, Tannu Dhingra, Guruswami Chalavady, Aishika Datta, Bijoyani Ghosh, Nikita Rana, Anupom Borah, Shailendra Saraf, Pallab Bhattacharya
Eukaryotic cells utilize oxygen for different functions of cell organelles owing to cellular survival. A balanced oxygen homeostasis is an essential requirement to maintain the regulation of normal cellular systems. Any changes in the oxygen level are stressful and can alter the expression of different homeostasis regulatory genes and proteins. Lack of oxygen or hypoxia results in oxidative stress
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Caffeic acid phenethyl ester mediates apoptosis in serum-starved HT29 colon cancer cells through modulation of heat shock proteins and MAPK pathways Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-26 Showket Yahya, Mahaboob Khan Sulaiman, Ganapasam Sudhandiran
Colorectal cancer (CRC) is among the most prevalent gastrointestinal cancers of epithelial origin worldwide, with over 2 million cases detected every year. Emerging evidence suggests a significant increase in the levels of inflammatory and stress-related markers in patients with CRC, indicating that oxidative stress and lipid peroxidation may influence signalling cascades involved in the progression
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Evaluation of telomere length, reactive oxygen species, and apoptosis in spermatozoa of patients with oligospermia Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-27 Ria Margiana, Reena Gupta, Watheq Mohammed Al-Jewari, Ahmed Hjazi, Hashem O. Alsaab, Yasser Fakri Mustafa, Rajesh Singh, Ruiscul Thaibt, Safa Alkhayyat, Ahmed Jaber Ibrahim
50% of cases of infertility are caused by male factor, which acquired or congenital problems may bring on. Male infertility can be caused by oligospermia and asthenozoospermia, which are common. Since the same mutations that cause azoospermia in some people also cause oligozoospermia in others, oligozoospermia may be thought of as a less severe form of azoospermia. Studies have demonstrated telomere
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SGLT2 inhibitors and AMPK: The road to cellular housekeeping? Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-23 Nasser Safaie, Shahab Masoumi, Shaban Alizadeh, Pourya Mirzajanzadeh, Hamid Reza Nejabati, Mobasher Hajiabbasi, Vahid Alivirdiloo, Neda Chobdari Basmenji, Aysan Derakhshi Radvar, Ziba Majidi, Yousef Faridvand
Sodium-glucose co-transporter-2 (SGLT2) inhibitors, known as Gliflozins, are a class of Glucose-lowering drugs in adults with type 2 diabetes (T2D) that induce glucosuria by blocking SGLT2 co-transporters in the proximal tubules. Several lines of evidence suggest that SGLT2 inhibitors regulate multiple mechanisms associated with the regulation of varying cellular pathways. The 5′-adenosine monophosphate-activated
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One carbon metabolism and its implication in health and immune functions Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-21 Shreya Dang, Arushi Jain, Garima Dhanda, Neetu Bhattacharya, Amit Bhattacharya, Sabyasachi Senapati
One carbon (1C) metabolism is critical for cellular viability and physiological homeostasis. Starting from its crucial involvement in purine biosynthesis to posttranslational modification of proteins, 1C metabolism contributes significantly to the development and cellular differentiation through methionine and folate cycles that are pivotal for cellular function. Genetic polymorphisms of several genes
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The role of TRPV ion channels in adipocyte differentiation: What is the evidence? Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-19 Wenyu Zou, Ling Zhang, Yongyan Hu, Ying Gao, Junqing Zhang, Jia Zheng
Obesity is a complex disorder, and the incidence of obesity continues to rise at an alarming rate worldwide. In particular, the growing incidence of overweight and obesity in children is a major health concern. However, the underlying mechanisms of obesity remain unclear and the efficacy of several approaches for weight loss is limited. As an important calcium-permeable temperature-sensitive cation
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Targeting PI3K/p-Akt/eNOS, Nrf2/HO-1, and NF-κB/p53 signaling pathways by angiotensin 1–7 protects against liver injury induced by ischemia–reperfusion in rats Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-22 Fatma Farrag Ali, Mostafa Mourad Mohammed, Youssef Hussein, Manar Fouli Gaber Ibrahim
The liver is an important organ, and hepatic ischemia–reperfusion (IR) injury is a frequent pathophysiological process that can cause significant morbidity and mortality. Thus, our study aimed to investigate the effect of targeting PI3K/p-Akt/eNOS (phosphoinositide 3-kinase/phospho-protein kinase B/endothelial nitric oxide synthase), Nrf2/HO-1 (nuclear factor-erythroid 2-related factor-2/heme oxygenase-1)
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Targeting NF-κB/COX-2 signaling by soyasaponin I alleviates diclofenac-induced gastric ulceration in male albino rats Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-21 Ahmed A. Morsi, Lamiaa M. Shawky, Tamer M. Shawky, Mohamed H. Bahr, Mahmoud Tawfiq Abu Alnasr, Eman El Bana
Gastric ulceration is a prevalent worldwide clinical presentation due to altered gastric defense mechanisms. Nonsteroidal anti-inflammatory drugs are one of the common causes of gastric ulcers mediated by the release of inflammatory mediators. The study aimed to investigate the potential protective effect of soyasaponin I (soya) against diclofenac (DIC)-induced gastric ulcer in rats and to highlight
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Salivary proteomic profile of response to different resistance training protocols: A case report Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-19 Karina Oliveira Santos, Dalton Muller Pessôa Filho, Talita Mendes Oliveira Ventura, Larissa Tercilia Grizzo Thomassian, Anderson Geremias Macedo, Marília Afonso Rabelo Buzalaf, Aline Silva Braga, Murilo Henrique Faria, Ana Carolina Magalhães
Resistance training (RT) with blood flow restriction (BFR) or high intensity (HI) are effective to increase muscle mass. To understand this effect, techniques known as “omics” are used to identify possible biomarkers. This study analyzed the salivary proteomic profile of healthy individuals trained before and after two RT protocols both designed with eight exercises for upper- and lower-limbs, one
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Purification and partial characterization of a sperm motility-inhibitory protein of ram cauda epididymal plasma Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-24 Pyare Lal, Kalpana Jorasia, Narendra Singh Rathore, Vijay Kumar, Raghvendar Singh, Anil Moolchandrani, Rajani Kr. Paul
Mammalian sperm remain quiescent but fertile for several weeks in cauda epididymis. Although several sperm quiescent factors of epididymal plasma have been identified in goat, pig and cattle; however, little is known in sheep. In the present study, purification and characterization of a novel sperm quiescent protein of ovine cauda epididymal plasma (CEP) was carried out. The sperm quiescent protein
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Dual regulation effect and mechanism of human myeloid-derived suppressor cells on anticolorectal cancer cells activity of Vγ9Vδ2 T cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-18 Mengyu Zhang, Yuanyuan Wu, Yahan Qin, Jie Shen, Zhao Cui, Fan Lei, Ke Zhang, Baiqing Li, Shujuan Liang, Meiyu Peng
Myeloid-derived suppressor cells (MDSC) are a group of immature inhibitory cells of bone marrow origin. Human γδ T cells (mainly Vγ9Vδ2 T cells) have emerged as dominant candidates for cancer immunotherapy because of their unique recognition pattern and broad killing activity against tumor cells. Intestinal mucosal intraepithelial lymphocytes are almost exclusively γδ T cells, so it plays an important
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Chitosan/alginate scaffold enhanced with Berberis vulgaris extract for osteocyte differentiation of ovine fetal stem cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-18 Leila Soltani, Hori Ghaneialvar, Naser Abbasi, Parvaneh Bayat, Maryam Nazari
Designing biocompatible polymers using plant derivatives can be extremely useful in tissue engineering, nanomedicine, and many other fields of medicine. In this study, it was first looked into how chitosan/alginate scaffolds were made and characterized in the presence of berberine and barberry fruit extract. Second, the process of proliferation and differentiation of ovine fetal BM-MSCs (bone marrow-mesenchymal
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Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1 Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-17 Beilei Gong, Liping Wang, Han Zhang, Qingkai Wang, Wei Li
Photodynamic therapy (PDT) is nowadays widely employed in cancer treatment. We sought to assess the efficacy of combining PDT with anti-programmed cell death protein 1 (PD1) and to investigate the associated mechanisms in nonsmall cell lung cancer (NSCLC). We established a xenograft tumor model in C57BL/6J mice using Lewis lung carcinoma (LLC) cells, recorded tumor growth, and quantified reactive oxygen
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Role of bio-flavonols and their derivatives in improving mitochondrial dysfunctions associated with pancreatic tumorigenesis Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-16 Vinit Sharma, Ankita Arora, Sakshi Bansal, Ankita Semwal, Mayank Sharma, Anjali Aggarwal
Mitochondria, a cellular metabolic center, efficiently fulfill cellular energy needs and regulate crucial metabolic processes, including cellular proliferation, differentiation, apoptosis, and generation of reactive oxygen species. Alteration in the mitochondrial functions leads to metabolic imbalances and altered extracellular matrix dynamics in the host, utilized by solid tumors like pancreatic cancer
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The emerging role of USP29 in cancer and other diseases Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-15 Ru Zhang, Zeqiong Cai, Doudou Ren, Ye Kang, Qi Zhang, Xinlan Lu, Rongfu Tu
Reversible protein ubiquitination is a key process for maintaining cellular homeostasis. Deubiquitinases, which can cleave ubiquitin from substrate proteins, have been reported to be deeply involved in disease progression ranging from oncology to neurological diseases. The human genome encodes approximately 100 deubiquitinases, most of which are poorly characterized. One of the well-characterized deubiquitases
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Correction to “Hypoxic preconditioning improves the survival and neural effects of transplanted mesenchymal stem cells via CXCL12/CXCR4 signalling in a rat model of cerebral infarction” Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-12
Hu Y, Chen W, Wu L, et al. Hypoxic preconditioning improves the survival and neural effects of transplanted mesenchymal stem cells via CXCL12/CXCR4 signalling in a rat model of cerebral infarction. Cell Biochemistry and Function, 2019, 37(7): 504-515. https://doi.org/10.1002/cbf.3423 In the originally published article, Figure 4B mistakenly showed a wrong image. The correct version of Figure 4B is
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Effective extracellular vesicles in glioma: Focusing on effective ncRNA exosomes and immunotherapy methods for treatment Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-01-11 Sulieman Ibraheem Shelash Al-Hawary, Sharif Alhajlah, Bokov Dmitry Olegovich, Ahmed Hjazi, Pranchal Rajput, Saad Hayif Jasim Ali, Munther Abosoda, Ali Ihsan, Shamam Kareem Oudah, Yasser Fakri Mustafa
This comprehensive article explores the complex field of glioma treatment, with a focus on the important roles of non-coding RNAsRNAs (ncRNAs) and exosomes, as well as the potential synergies of immunotherapy. The investigation begins by examining the various functions of ncRNAs and their involvement in glioma pathogenesis, progression, and as potential diagnostic biomarkers. Special attention is given