-
Retraction: miR‐212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells IUBMB Life (IF 4.6) Pub Date : 2024-03-14
Retraction: ‘’ by Jian‐Li Zhao , Le Zhang, Xu Guo , Jing‐Hua Wang , Wen Zhou , Min Liu , Xin Li and Hua Tang , IUBMB Life 2015, 67, 380–394 : The above article, published online on 15 May 2015 on Wiley Online Library (https://doi.org/10.1002/iub.1381) has been retracted by agreement between the journal's Editor in Chief, Dr. Efstathios S. Gonos, and Wiley Periodicals LLC.The retraction has been agreed
-
Particulate matters 2.5 induce tumor progression in lung cancer by increasing the activity of hnRNPA2B1 resulting in retarding mRNA decay of oxidative phosphorylation IUBMB Life (IF 4.6) Pub Date : 2024-03-07 Wen Bian, Haifeng Yu, Xiaofei Zhang, Yuxuan Wang, Bin Ni
Particulate matter 2.5 (PM2.5) has been implicated in lung injury and various cancers, yet its precise mechanistic role remains elusive. To elucidate the key signaling pathways underpinning PM2.5‐induced lung cancer progression, we embarked on a study examining the impact of PM2.5 both in vitro and in vivo. Lung cancer cell lines, A549 and H157, were employed for the in vitro investigations. Overexpression
-
Nano-therapeutics: The upcoming nanomedicine to treat cancer IUBMB Life (IF 4.6) Pub Date : 2024-03-05 Hamda Khan, Uzma Shahab, Ahmed Alshammari, Amjad R. Alyahyawi, Rihab Akasha, Talal Alharazi, Rizwan Ahmad, Afreen Khanam, Safia Habib, Kirtanjot Kaur, Saheem Ahmad, Moinuddin
Nanotechnology is considered a successful approach for cancer diagnosis and treatment. Preferentially, cancer cell recognition and drug targeting via nano-delivery system include the penetration of anticancer agents into the cell membrane to damage the cancer cell by protein modification, DNA oxidation, or mitochondrial dysfunction. The past research on nano-delivery systems and their target has proven
-
The complex relationship between late‐onset caloric restriction and synaptic plasticity in aged Wistar rats IUBMB Life (IF 4.6) Pub Date : 2024-02-23 Milica Prvulovic, Srdjan Sokanovic, Valentina Simeunovic, Andjela Vukojevic, Milena Jovic, Smilja Todorovic, Aleksandra Mladenovic
Age‐related reduction in spine density, synaptic marker expression, and synaptic efficiency are frequently reported. These changes provide the cellular and molecular basis for the cognitive decline characteristic for old age. Nevertheless, there are several approaches that have the potential to ameliorate these processes and improve cognition, caloric restriction being one of the most promising and
-
Evolution and variation in amide aminoacyl‐tRNA synthesis IUBMB Life (IF 4.6) Pub Date : 2024-02-23 Alexander M. Lewis, Trevor Fallon, Georgia A. Dittemore, Kelly Sheppard
The amide proteogenic amino acids, asparagine and glutamine, are two of the twenty amino acids used in translation by all known life. The aminoacyl‐tRNA synthetases for asparagine and glutamine, asparaginyl‐tRNA synthetase and glutaminyl tRNA synthetase, evolved after the split in the last universal common ancestor of modern organisms. Before that split, life used two‐step indirect pathways to synthesize
-
Exosomes derived from Baicalin‐pretreated bone mesenchymal stem cells improve Th17/Treg imbalance after hepatic ischemia–reperfusion via FGF21 and the JAK2/STAT3 pathway IUBMB Life (IF 4.6) Pub Date : 2024-02-21 Baoyan Zhang, Linfeng Su, Zhichao Chen, Min Wu, Jianfeng Wei, Yonghua Lin
Baicalin is an active compound extracted from Scutellaria baicalensis with antioxidant and anti‐inflammatory properties. Bone mesenchymal stem cells (BMSCs)‐derived exosomes have shown promise for the treatment of hepatic ischemia–reperfusion (I/R) injury. This study aims to investigate the role of Baicalin‐pretreated BMSCs‐derived exosomes in hepatic I/R injury and its mechanisms. BMSCs were pretreated
-
Alternative splicing generates a novel ferroportin isoform with a shorter C-terminal and an intact iron- and hepcidin-binding property IUBMB Life (IF 4.6) Pub Date : 2024-02-13 Pallavi Juneja, Naira Rashid, Faizan Abul Qais, Supriya Tanwar, Insha Sultan, Faizan Ahmad, Sayeed ur Rehman
Ferroportin (FPN) is a transmembrane protein and is the only known iron exporter that helps in maintaining iron homeostasis in vertebrates. To maintain stable iron equilibrium in the body, ferroportin works in conjunction with a peptide called hepcidin. In this study, we have identified an alternatively spliced novel isoform of the human SLC40A1 gene, which encodes for the FPN protein and is found
-
-
Screening and experimental validation of diagnostic gene in ulcerative colitis with anti-TNF-α therapy IUBMB Life (IF 4.6) Pub Date : 2024-01-25 Yuan Chen, Xinfang Li, Ran Sun, Fan Yang, Weiliang Tian, Qian Huang
In clinical practice, the diagnosis of ulcerative colitis (UC) mainly relies on a comprehensive analysis of a series of signs and symptoms of patients. The current biomarkers for diagnosis of UC and prognostic prediction of anti-TNF-α therapy are inaccurate. The present study aimed to perform an integrative analysis of gene expression profiles in patients with UC. A total of seven datasets from the
-
HNRNPA2B1 promotes oral squamous cell carcinogenesis via m6A-dependent stabilization of FOXQ1 mRNA stability IUBMB Life (IF 4.6) Pub Date : 2024-01-24 Xi Wang, Min Zhi, Wei Zhao, Jiayin Deng
Oral squamous cell carcinoma (OSCC), as a common type of oral malignancy, has an unclear pathogenesis. N6 methyladenosine (m6A) is a reversible and dynamic process that participates in the modulation of cancer pathogenesis and development. As an m6A recognition protein (reader), heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) show abnormally high expression in cancers. Forkhead box Q1 (FOXQ1)
-
MRAS in coronary artery disease—Unchartered territory IUBMB Life (IF 4.6) Pub Date : 2024-01-22 Pashmina Wiqar Shah, Tobias Reinberger, Satwat Hashmi, Zouhair Aherrahrou, Jeanette Erdmann
Genome-wide association studies (GWAS) have identified coronary artery disease (CAD) susceptibility locus on chromosome 3q22.3. This locus contains a cluster of several genes that includes muscle rat sarcoma virus (MRAS). Common MRAS variants are also associated with CAD causing risk factors such as hypertension, dyslipidemia, obesity, and type II diabetes. The MRAS gene is an oncogene that encodes
-
Wnt signaling in cell adhesion, development, and colon cancer IUBMB Life (IF 4.6) Pub Date : 2024-01-17 Nydia Tejeda-Muñoz, Kuo-Ching Mei
Wnt signaling is essential for embryonic development, influencing processes such as axis formation, cell proliferation and differentiation, cell fate decisions, and axon guidance. It also plays a role in maintaining tissue homeostasis in adult organisms. The loss of normal cell polarity and adhesion caused by Wnt signaling activation is a fundamental step for tumor progression and metastasis. Activating
-
Matrix-based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma IUBMB Life (IF 4.6) Pub Date : 2024-01-02 Nicholas S. Mastronikolis, Efthymios Kyrodimos, Zoi Piperigkou, Despoina Spyropoulou, Alexander Delides, Evangelos Giotakis, Miranda Alexopoulou, Nick A. Bakalis, Nikos K. Karamanos
Oral squamous cell carcinoma (OSCC) is a head and neck cancer (HNC) with a high mortality rate. OSCC is developed in the oral cavity and it is triggered by many etiologic factors and can metastasize both regionally and distantly. Recent research advances in OSCC improved our understanding on the molecular mechanisms involved in and the initiation of OSCC metastasis. The key roles of the extracellular
-
-
The tumor immune microenvironment remodeling and response to HER2-targeted therapy in HER2-positive advanced gastric cancer IUBMB Life (IF 4.6) Pub Date : 2023-12-21 Lei Jiang, Xingwang Zhao, Yilin Li, Yajie Hu, Yu Sun, Shengde Liu, Zizhen Zhang, Yanyan Li, Xujiao Feng, Jiajia Yuan, Jian Li, Xiaotian Zhang, Yang Chen, Lin Shen
Combination therapy with anti-HER2 agents and immunotherapy has demonstrated significant clinical benefits in gastric cancer (GC), but the underlying mechanism remains unclear. In this study, we used multiplex immunohistochemistry to assess the changes of the tumor microenvironment in 47 advanced GC patients receiving anti-HER2 therapy. Additionally, we performed single-cell transcriptional sequencing
-
Schizosaccharomyces pombe as a fundamental model for research on mitochondrial gene expression: Progress, achievements and outlooks IUBMB Life (IF 4.6) Pub Date : 2023-12-20 Nhu Dinh, Nathalie Bonnefoy
Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial research. The organism resembles human cells in terms of mitochondrial inheritance, mitochondrial transport, sugar metabolism, mitogenome structure and dependence of viability on the mitogenome (the petite-negative phenotype). Transcriptions of these genomes produce only a few polycistronic transcripts, which then undergo
-
The CD40/CD40 ligand dyad and its downstream effector molecule ISG54 in relating acute neuroinflammation with persistent, progressive demyelination IUBMB Life (IF 4.6) Pub Date : 2023-12-20 Bishal Hazra, Jayasri Das Sarma
Although Multiple Sclerosis (MS) is primarily thought to be an autoimmune condition, its possible viral etiology must be taken into consideration. When mice are administered neurotropic viruses like mouse hepatitis virus MHV-A59, a murine coronavirus, or its isogenic recombinant strain RSA59, neuroinflammation along with demyelination are observed, which are some of the significant manifestations of
-
In memoriam: Prof. Dr. rer. nat. Jeanette Erdmann IUBMB Life (IF 4.6) Pub Date : 2023-12-14 Pashmina Wiqar Shah, Satwat Hashmi, Tobias Reinberger, Nadine Odenthal, Luis Eichelmann, Daria Kosenko, Ilyas Ahmad, Jaafar Al-Hasani, Till Joscha Demal, Zouhair Aherrahrou, Rédouane Aherrahrou
1 INTRODUCTION Prof. Dr. Jeanette Erdmann, a distinguished cardiovascular geneticist who served as Professor at the Institute of Cardiogenetics at the University of Lübeck and at the German Center for Cardiovascular Research (DZHK), passed away suddenly at her residence in Lübeck at the age of 57 on July 9, 2023. She had also served as the deputy editor of IUBMB Life.
-
A hub for regulation of mitochondrial metabolism: Fatty acid and lipoic acid biosynthesis IUBMB Life (IF 4.6) Pub Date : 2023-12-13 Carol L. Dieckmann
Having evolved from a prokaryotic origin, mitochondria retain pathways required for the catabolism of energy-rich molecules and for the biosynthesis of molecules that aid catabolism and/or participate in other cellular processes essential for life of the cell. Reviewed here are details of the mitochondrial fatty acid biosynthetic pathway (FAS II) and its role in building both the octanoic acid precursor
-
Viral infection and host immune response in diabetes IUBMB Life (IF 4.6) Pub Date : 2023-12-08 Garima Joshi, Anushka Das, Garima Verma, Prasenjit Guchhait
Diabetes, a chronic metabolic disorder disrupting blood sugar regulation, has emerged as a prominent silent pandemic. Uncontrolled diabetes predisposes an individual to develop fatal complications like cardiovascular disorders, kidney damage, and neuropathies and aggravates the severity of treatable infections. Escalating cases of Type 1 and Type 2 diabetes correlate with a global upswing in diabetes-linked
-
Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS-COV-2 targeting main protease and papain-like protease IUBMB Life (IF 4.6) Pub Date : 2023-12-07 Shweta Choudhary, Sanketkumar Nehul, Ankur Singh, Prasan Kumar Panda, Pravindra Kumar, Gaurav Kumar Sharma, Shailly Tomar
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be over, but its variants continue to emerge, and patients with mild symptoms having long COVID is still under investigation. SARS-CoV-2 infection leading to elevated cytokine levels and suppressed immune responses set off cytokine storm, fatal systemic inflammation, tissue damage
-
Amino acid deprivation induces TXNIP expression by NRF2 downregulation IUBMB Life (IF 4.6) Pub Date : 2023-12-06 Se Hee Ahn, Se-Kyeong Jang, Yu Jin Kim, Gyeongmi Kim, Ki Soo Park, In-Chul Park, Hyeon-Ok Jin
Thioredoxin-interacting protein (TXNIP) is sensitive to oxidative stress and is involved in the pathogenesis of various metabolic, cardiovascular, and neurodegenerative disorders. Therefore, several studies have suggested that TXNIP is a promising therapeutic target for several diseases, particularly cancer and diabetes. However, the regulation of TXNIP expression under amino acid (AA)-restricted conditions
-
Fingolimod (FTY720), an FDA-approved sphingosine 1-phosphate (S1P) receptor agonist, restores endothelial hyperpermeability in cellular and animal models of dengue virus serotype 2 infection IUBMB Life (IF 4.6) Pub Date : 2023-11-30 Ayan Modak, Srishti Rajkumar Mishra, Mansi Awasthi, Arya Aravind, Sneha Singh, Easwaran Sreekumar
Extensive vascular leakage and shock is a major cause of dengue-associated mortality. At present, there are no specific treatments available. Sphingolipid pathway is a key player in the endothelial barrier integrity; and is mediated through the five sphingosine-1-phosphate receptors (S1PR1-S1PR5). Signaling through S1PR2 promotes barrier disruption; and in Dengue virus (DENV)-infection, there is overexpression
-
-
Functional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children IUBMB Life (IF 4.6) Pub Date : 2023-11-28 Lei Lin, Bo Wang, Xinxin Zhang, Changmi Deng, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Jing He
The 5-methylcytosine (m5C) is the key chemical modification in RNAs. As one of the demethylases in m5C, TET2 has been shown as a tumor suppressor. However, the impact of TET2 gene polymorphisms on neuroblastoma has not been elucidated. 402 neuroblastoma patients and 473 controls were genotyped for TET2 gene polymorphisms using the TaqMan method. The impact of TET2 gene polymorphisms on neuroblastoma
-
Addressing the impact of high glucose microenvironment on the immunosuppressive characteristics of human mesenchymal stem cells IUBMB Life (IF 4.6) Pub Date : 2023-11-28 Ramada R. Khasawneh, Ejlal Abu-El-Rub, Fatimah A. Almahasneh, Ayman Alzu'bi, Hana M. Zegallai, Rawan A. Almazari, Huthaifa Magableh, Mohammad H. Mazari, Haitham F. Shlool, Ahmad K. Sanajleh
Mesenchymal stem cells (MSCs) are a therapeutically efficient type of stem cells validated by their ability to treat many inflammatory and chronic conditions. The biological and therapeutic characteristics of MSCs can be modified depending on the type of microenvironment at the site of transplantation. Diabetes mellitus (DM) is a commonly diagnosed metabolic disease characterized by hyperglycemia,
-
Vincristine exposure impairs mouse oocyte quality by inducing spindle defects and early apoptosis IUBMB Life (IF 4.6) Pub Date : 2023-11-27 Haoya Chang, Siyu Cheng, Guoqiang Xing, Chenyang Huang, Chunhui Zhang, Weiping Qian, Jian Li
Vincristine (VCR) is a microtubule-destabilizing chemotherapeutic agent commonly administered for the treatment of cancers in patients, which can induce severe side effects including neurotoxicity. In context of the effects on female fertility, ovarian toxicity has been found in patients and mice model after VCR exposure. However, the influence of VCR exposure on oocyte quality has not been elucidated
-
Correction to “Retraction” IUBMB Life (IF 4.6) Pub Date : 2023-11-15
Retraction. IUBMB Life. 2023;75(7):643–643. https://doi.org/10.1002/iub.2717 In the originally published retraction, the sentence, “As a result, the editor's conclusions of this article are considered to be invalid” should read, “As a result, the editor considers the conclusions of this article to be invalid.” We apologize for this error.
-
1,25(OH)2D3 inhibits Lewis lung cancer cell migration via NHE1-sensitive metabolic reprograming IUBMB Life (IF 4.6) Pub Date : 2023-11-03 Hong Chen, Mei-zhen Zhu, Xi-ting Wang, Min Ai, Shuang-shuang Li, Ming-yu Wan, Pei-yao Wang, Wei-wei Cai, Bao Hou, Fei Xu, Florian Lang, Li-ying Qiu, Yue-tao Zhou
High prevalence and metastasis rates are characteristics of lung cancer. Glycolysis provides energy for the development and metastasis of cancer cells. The 1,25-dihydroxy vitamin D3 (1,25(OH)2D3) has been linked to reducing cancer risk and regulates various physiological functions. We hypothesized that 1,25(OH)2D3 could be associated with the expression and activity of Na+/H+ exchanger isoform 1 (NHE1)
-
Correction to “LncRNA RAD51-AS1/miR-29b/c-3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer” IUBMB Life (IF 4.6) Pub Date : 2023-10-20
Li C, Wang P, Du J, Chen J, Liu W, Ye K. LncRNA RAD51-AS1/miR-29b/c-3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer. IUBMB Life. 2021; 73:286–298. https://doi.org/10.1002/iub.2427 In the originally published article, a funding source was left out of the Acknowledgements. “Natural Science Foundation of Fujian Province of China, 2019J01170” should have been included
-
-
N-acetylneuraminic acid modulates SQSTM1/p62 sialyation-mediated ubiquitination degradation contributing to vascular endothelium dysfunction in experimental atherosclerosis mice IUBMB Life (IF 4.6) Pub Date : 2023-10-11 Le Chen, Hongmei Qiu, Qingqiu Chen, Peng Xiang, Jin Lei, Jun Zhang, Yining Lu, Xianmin Wang, Shengde Wu, Chao Yu, Limei Ma
Sialic acid (SIA) has been reported to be a risk factor for atherosclerosis (AS) due to its high plasma levels in such patients. However, the effect of increasing SIA in circulation on endothelial function during AS progression remains unclear. In the present study, ApoE−/− mice and endothelial cells line (HUVEC cells) were applied to investigate the effect of SIA on AS progression and its potential
-
miR-203a—A multifaceted regulator modulating cancer hallmarks and therapy response IUBMB Life (IF 4.6) Pub Date : 2023-10-04 Priyajit Biswal, Anthony Lalruatfela, Subham Kumar Behera, Sruti Biswal, Bibekanand Mallick
MicroRNAs (miRNAs) are a class of noncoding RNAs of about 19–25 nucleotides, which serve as critical modulators of various cellular and biological processes by target gene regulation. Dysregulated expression of miRNAs modulates the pathophysiology of various human diseases, including cancer. Among miRNAs, miR-203a is one of the most extensively researched dysregulated miRNAs in different cancers. Our
-
Mitochondrial protein and organelle quality control—Lessons from budding yeast IUBMB Life (IF 4.6) Pub Date : 2023-09-20 Emily Jie-Ning Yang, Pin-Chao Liao, Liza Pon
Mitochondria are essential for normal cellular function and have emerged as key aging determinants. Indeed, defects in mitochondrial function have been linked to cardiovascular, skeletal muscle and neurodegenerative diseases, premature aging, and age-linked diseases. Here, we describe mechanisms for mitochondrial protein and organelle quality control. These surveillance mechanisms mediate repair or
-
Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway IUBMB Life (IF 4.6) Pub Date : 2023-09-20 Weiye Liang, Mingkai Liu, Yuling Su, Yulin Wen, Lili Wang, Jiajie Shan, Jie Zhao, Keping Xie, Jian Wang
The molecular mechanisms of glioblastoma (GBM) are unclear, and the prognosis is poor. Spinster homolog 2 (SPNS2) is reportedly involved in pathological processes such as immune response, vascular development, and cancer. However, the biological function and molecular role of SPNS2 in GBM are unclear. SPNS2 is aberrantly low expressed in glioma. Survival curves, risk scores, prognostic nomograms, and
-
Early steps in the biogenesis of mitochondrially encoded oxidative phosphorylation subunits IUBMB Life (IF 4.6) Pub Date : 2023-09-15 Sung-jun Jung, Sagar Sridhara, Martin Ott
The complexes mediating oxidative phosphorylation (OXPHOS) in the inner mitochondrial membrane consist of proteins encoded in the nuclear or the mitochondrial DNA. The mitochondrially encoded membrane proteins (mito-MPs) represent the catalytic core of these complexes and follow complicated pathways for biogenesis. Owing to their overall hydrophobicity, mito-MPs are co-translationally inserted into
-
Cover Image IUBMB Life (IF 4.6) Pub Date : 2023-09-13
On the Cover: The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome requires two parallel steps for activation: priming (left) and activation (right). DAMPs or PAMPs stimuli are recognized by TLRs or cytokine receptors during the priming phase, which induce the mRNA expression of the pro IL-1b and pro IL-18 as well as NLRP3 through the NF-kB signaling pathway. The second phase (the
-
Tatenda Murigo: A passionate advocate for science in Africa (June 17, 2000-July 14, 2023). IUBMB Life (IF 4.6) Pub Date : 2023-09-04 Victoria Patten,Elyse Fischer,Patrick Penndorf,Alexandra C Newton
-
Erratum to Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis IUBMB Life (IF 4.6) Pub Date : 2023-08-31
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, et al. Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis. IUBMB Life. 2023;75(7):624–42. https://doi.org/10.1002/iub.2711 In the originally published article, author Hang Fu's affiliations were given incorrectly. The correct affiliations are below. 1 First Clinical Medical
-
Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy IUBMB Life (IF 4.6) Pub Date : 2023-08-25 Stella Newell, Pauline J. van der Watt, Virna D. Leaner
Systemic modalities are crucial in the management of disseminated malignancies and liquid tumours. However, patient responses and tolerability to treatment are generally poor and those that enter remission often return with refractory disease. Combination therapies provide a methodology to overcome chemoresistance mechanisms and address dose-limiting toxicities. A deeper understanding of tumorigenic
-
LncRTPred: Predicting RNA–RNA mode of interaction mediated by lncRNA IUBMB Life (IF 4.6) Pub Date : 2023-08-22 Gourab Das, Troyee Das, Sibun Parida, Zhumur Ghosh
Long non-coding RNAs (lncRNAs) play a significant role in various biological processes. Hence, it is utmost important to elucidate their functions in order to understand the molecular mechanism of a complex biological system. This versatile RNA molecule has diverse modes of interaction, one of which constitutes lncRNA–mRNA interaction. Hence, identifying its target mRNA is essential to understand the
-
Long-term abuse of caffeine sodium benzoate induces endothelial cells injury and leads to coagulation dysfunction IUBMB Life (IF 4.6) Pub Date : 2023-08-19 Tianwei Yu, Hongwei Wang, Rong Guo, Jianzhong Liu, Lili Tian, Suri Guga, Weixin Li, Huiying Zhao, Feiya Suo, Hao Yang, Quanzhi Yan
Our hospital admitted a patient who had difficulty in coagulation even after blood replacement, and the patient had abused caffeine sodium benzoate (CSB) for more than 20 years. Hence, we aimed to explore whether CSB may cause dysfunction in vascular endothelial cells and its possible mechanism. Low, medium, and high concentrations of serum of long-term CSB intake patients were used to treat HUVECs
-
RNA processing and degradation mechanisms shaping the mitochondrial transcriptome of budding yeasts IUBMB Life (IF 4.6) Pub Date : 2023-08-18 Pawel Golik
Yeast mitochondrial genes are expressed as polycistronic transcription units that contain RNAs from different classes and show great evolutionary variability. The promoters are simple, and transcriptional control is rudimentary. Posttranscriptional mechanisms involving RNA maturation, stability, and degradation are thus the main force shaping the transcriptome and determining the expression levels
-
Cover Image IUBMB Life (IF 4.6) Pub Date : 2023-08-14
On the Cover: Schematic representation of LINC01376 mediated effects observed in the present study by Peng et al.; Article first published: 27 March 2023; https://doi.org/10.1002/iub.2721
-
RetroGREAT signaling: The lessons we learn from yeast IUBMB Life (IF 4.6) Pub Date : 2023-08-10 Thi Hoang Diu Bui, Karolina Labedzka-Dmoch
The mitochondrial retrograde signaling (RTG) pathway of communication from mitochondria to the nucleus was first studied in yeast Saccharomyces cerevisiae. It rewires cellular metabolism according to the mitochondrial state by reprogramming nuclear gene expression in response to mitochondrial triggers. The main players involved in retrograde signaling are the Rtg1 and Rtg3 transcription factors, and
-
Machine learning-based establishment and validation of age-related patterns for predicting prognosis in non-small cell lung cancer within the context of the tumor microenvironment IUBMB Life (IF 4.6) Pub Date : 2023-08-07 Zeming Ma, Haibo Han, Zhiwei Zhou, Shijie Wang, Fan Liang, Liang Wang, Hong Ji, Yue Yang, Jinfeng Chen
Lung cancer (LC) is a leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for over 80% of cases. The impact of aging on clinical outcomes in NSCLC remains poorly understood, particularly with respect to the immune response. In this study, we explored the effects of aging on NSCLC using 307 genes associated with human aging from the Human Ageing Genomic
-
Glycolipotoxicity conferred tendinopathy through ferroptosis dictation of tendon-derived stem cells by YAP activation IUBMB Life (IF 4.6) Pub Date : 2023-07-28 Gang Wang, Shikun Wang, Xingyu Ouyang, Hui Wang, Xiao Li, Zhixiao Yao, Shuai Chen, Cunyi Fan
Tendinopathy is a condition characterized by chronic, complex, and multidimensional pathological changes in the tendons. The etiology of tendinopathy is the combination of several factors, and diabetes mellitus (DM) is a risk factor. Increasing evidence has shown that the diabetic microenvironment plays an important role in tendinopathy. However, the mechanism causing tendinopathy in patients with
-
Combined doxorubicin and arctigenin treatment induce cell cycle arrest-associated cell death by promoting doxorubicin uptake in doxorubicin-resistant breast cancer cells IUBMB Life (IF 4.6) Pub Date : 2023-07-26 Min-Gu Lee, Kyu-Shik Lee, Kyung-Soo Nam
Chemotherapy failure is often caused by drug resistance, for which no effective treatment strategy has been established. Many studies have been undertaken with the aim of overcoming drug resistance using natural products. Arctigenin (ATG), a natural product, has been investigated for its anti-cancer effects in HER2-overexpressing, ER-positive, and triple-negative breast cancer cells. We investigated
-
Humanized disulfide-stabilized diabody against fibroblast growth factor-2 inhibits PD-L1 expression and epithelial-mesenchymal transition in hepatoma cells through STAT3 IUBMB Life (IF 4.6) Pub Date : 2023-07-25 Huamin Sun, Xinran Song, Cunjie Li, Qing Li, Shifeng Liu, Ning Deng
Fibroblast growth factor 2 (FGF2) plays an important role in tumor angiogenesis. Humanized disulfide-stable double-chain antibody against fibroblast growth factor-2 (anti-FGF2 ds-Diabody) is a small molecule antibody with good tissue permeability and low immunogenicity, which has potential in tumor-targeted therapy. This study intended to investigate the effect of anti-FGF2 ds-Diabody on the migration
-
Cover Image IUBMB Life (IF 4.6) Pub Date : 2023-07-20
On the Cover: Mechanism of action of SGLT2 inhibitors. Proximal tubules are responsible for glucose reabsorption and on their membrane, there are SGLT2 transporters that can absorb glucose from the lumen, with subsequent transferring of glucose to blood via glucose transporters (GLUTs). SGLT2 inhibitors target proximal tubules, reducing glucose reabsorption to blood by Yaribeygi et al.; Article first
-
The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG-related disorders IUBMB Life (IF 4.6) Pub Date : 2023-07-20 Alexandru Ionut Gilea, Martina Magistrati, Ilenia Notaroberto, Natascia Tiso, Cristina Dallabona, Enrico Baruffini
Most eukaryotes possess a mitochondrial genome, called mtDNA. In animals and fungi, the replication of mtDNA is entrusted by the DNA polymerase γ, or Pol γ. The yeast Pol γ is composed only of a catalytic subunit encoded by MIP1. In humans, Pol γ is a heterotrimer composed of a catalytic subunit homolog to Mip1, encoded by POLG, and two accessory subunits. In the last 25 years, more than 300 pathological
-
Biolistic transformation of the yeast Saccharomyces cerevisiae mitochondrial DNA IUBMB Life (IF 4.6) Pub Date : 2023-07-20 Leticia Veloso Ribeiro Franco, Mario H. Barros
The insertion of genes into mitochondria by biolistic transformation is currently only possible in the yeast Saccharomyces cerevisiae and the algae Chlamydomonas reinhardtii. The fact that S. cerevisiae mitochondria can exist with partial (ρ− mutants) or complete deletions (ρ0 mutants) of mitochondrial DNA (mtDNA), without requiring a specific origin of replication, enables the propagation of exogenous
-
Adenine nucleotide carrier protein dysfunction in human disease IUBMB Life (IF 4.6) Pub Date : 2023-07-14 Gargi Mishra, Liam P. Coyne, Xin Jie Chen
Adenine nucleotide translocase (ANT) is the prototypical member of the mitochondrial carrier protein family, primarily involved in ADP/ATP exchange across the inner mitochondrial membrane. Several carrier proteins evolutionarily related to ANT, including SLC25A24 and SLC25A25, are believed to promote the exchange of cytosolic ATP-Mg2+ with phosphate in the mitochondrial matrix. They allow a net accumulation
-
Recent advances in BCRP-induced breast cancer resistance treatment with marine-based natural products IUBMB Life (IF 4.6) Pub Date : 2023-07-13 Jovita Kanoujia, Anjali Das, Neha Raina, Ginpreet Kaur, Sandeep K. Singh, Hardeep S. Tuli, Ashish Garg, Madhu Gupta
Breast cancer is the prominent cause of cancer-related death in women globally in terms of incidence and mortality. Despite, recent advances in the management of breast cancer, there are still a lot of cases of resistance to medicines, which is currently one of the biggest problems faced by researchers across the globe. Out of several mechanisms, breast cancer resistance protein (BCRP) arbitrated drug
-
Mechanisms of adaptive hypertrophic cardiac remodeling in a large animal model of premature ventricular contraction-induced cardiomyopathy IUBMB Life (IF 4.6) Pub Date : 2023-07-10 Jaime Balderas-Villalobos, J. M. Lourdes Medina-Contreras, Christopher Lynch, Rajiv Kabadi, Janée Hayles, Rafael J. Ramirez, Alex Y. Tan, Karoly Kaszala, Montserrat Samsó, Jose F. Huizar, Jose M. Eltit
Frequent premature ventricular contractions (PVCs) promoted eccentric cardiac hypertrophy and reduced ejection fraction (EF) in a large animal model of PVC-induced cardiomyopathy (PVC-CM), but the molecular mechanisms and markers of this hypertrophic remodeling remain unexplored. Healthy mongrel canines were implanted with pacemakers to deliver bigeminal PVCs (50% burden with 200–220 ms coupling interval)
-
The long intergenic noncoding RNA ARES modulates root architecture in Arabidopsis IUBMB Life (IF 4.6) Pub Date : 2023-07-06 Thomas Roulé, María Florencia Legascue, Andana Barrios, Nicolás Gaggion, Martin Crespi, Federico Ariel, Thomas Blein
Long noncoding RNAs (lncRNAs) have emerged as important regulators of gene expression in plants. They have been linked to a wide range of molecular mechanisms, including epigenetics, miRNA activity, RNA processing and translation, and protein localization or stability. In Arabidopsis, characterized lncRNAs have been implicated in several physiological contexts, including plant development and the response
-
Cover Image IUBMB Life (IF 4.6) Pub Date : 2023-06-20
On the Cover: Mechanistic diagram of 2-DG inhibiting cervical cancer progression in vitro by Su et al.; Article first published: 21 February 2023; https://doi.org/10.1002/iub.2706
-
Lobeline: A multifunctional alkaloid modulates cholinergic and glutamatergic activities IUBMB Life (IF 4.6) Pub Date : 2023-06-19 Chandran Remya, Kalarickal V. Dileep, Elessery J. Variyar, Ramakrishnapillai V. Omkumar, Chittalakkottu Sadasivan
Developing drugs for Alzheimer's disease (AD) is an extremely challenging task due to its devastating pathology. Previous studies have indicated that natural compounds play a crucial role as lead molecules in the development of drugs. Even though, there are remarkable technological advancements in the isolation and synthesis of natural compounds, the targets for many of them are still unknown. In the
-
Liraglutide ameliorates hepatic steatosis via retinoic acid receptor-related orphan receptor α-mediated autophagy pathway IUBMB Life (IF 4.6) Pub Date : 2023-06-13 Xiaoqian Yu, Xiaoqi Bian, Hongmei Zhang, Shanshan Yang, Daxin Cui, Zhiguang Su
Liraglutide, an analog of human glucagon-like peptide-1 (GLP-1), has been found to improve hepatic steatosis in clinical practice. However, the underlying mechanism remains to be fully defined. Increasing evidence suggests that retinoic acid receptor-related orphan receptor α (RORα) is involved in hepatic lipid accumulation. In the current study, we investigated whether the ameliorating impact of liraglutide
-
Mesenchymal stem cells (MSCs) and MSC-derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome IUBMB Life (IF 4.6) Pub Date : 2023-06-06 Shahrzad Nazari, Seyed Mahmoud Pourmand, Elahe Motevaseli, Gholamreza Hassanzadeh
The NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is a multimeric protein complex that is engaged in the innate immune system and plays a vital role in inflammatory reactions. Activation of the NLRP3 inflammasome and subsequent release of proinflammatory cytokines can be triggered by microbial infection or cellular injury. The NLRP3 inflammasome has been implicated in the pathogenesis