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Female fertility and the mammalian egg's zona pellucida. Histol. Histopathol. (IF 2.0) Pub Date : 2024-03-04 Paul M Wassarman, Eveline S Litscher
All mammalian eggs are surrounded by a relatively thick extracellular matrix (ECM) or zona pellucida (ZP) to which free-swimming sperm bind in a species-restricted manner during fertilization. The ZP consists of either three (e.g., Mus musculus) or four (e.g., Homo sapiens) glycosylated proteins, called ZP1-4. These proteins are unlike those found in somatic cell ECM, are encoded by single-copy genes
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The immune microenvironment of cancer of the uterine cervix. Histol. Histopathol. (IF 2.0) Pub Date : 2024-03-01 Michail Mastrogeorgiou, Elena Chatzikalil, Stamatios Theocharis, Alexandra Papoudou-Bai, Michel Péoc'h, Mousa Mobarki, Georgia Karpathiou
While several treatment choices exist for cervical cancer, such as surgical therapy, chemotherapy, and radiotherapy, some patients will still show poor prognosis. HPV infection is a principal factor for cervical cancer development, from early inflammation to proliferation, angiogenesis, and neoplastic growth. While HPV T-cell responses exist, the tumor seems to evade the immune system upon its tolerance
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Histological and morphometrical evaluation of the urethral wall after bioresorbable stent implantation in male New Zealand White Rabbits: A preliminary study. Histol. Histopathol. (IF 2.0) Pub Date : 2024-02-19 Joanna Skonieczna-Kurpiel, Jan P Madej, Tomasz Klekiel, Agnieszka Mackiewicz, Romuald Będziński, Agnieszka Noszczyk-Nowak, Tomasz Piasecki, Cassandra Ceccopieri
The aim of the study was the histological and morphometrical evaluation of the urethral wall at three time points after bioresorbable stent implantation in male New Zealand White Rabbits. The research was performed on 26 male New Zealand White rabbits aged 3-4 months and weighing 2.1-3.0 kg. Two models of bioresorbable sodium alginate-based stents were developed and implanted into the urethral lumen
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Neuregulin 1 (NRG1) and its receptors in the enteric nervous system and other parts of the gastrointestinal wall. Histol. Histopathol. (IF 2.0) Pub Date : 2024-02-14 Slawomir Gonkowski
Neuregulin 1 (NRG1) belonging to the transmembrane growth factors family is widespread in living organisms. It acts through ErbB family receptors and first of all takes part in embryogenesis, as well as in developmental, regenerative and adaptive processes occurring in various internal organs and systems. It is known that NRG1 and its receptors are present in various parts of the gastrointestinal (GI)
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RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4. Histol. Histopathol. (IF 2.0) Pub Date : 2024-02-09 Wei Zhang, Qian Xu, Chunmei Shi, Xinfeng Chen, Cheng Shen, Yong Zhang, Bing Zheng, Hua Zhu
Dead-End 1 (DND1) is an RNA-binding protein (RBP) with regulatory functions in multiple cancers, including gastric and colorectal. Nevertheless, the role that DND1 plays in prostatic cancer (PCa) as well as the hidden molecular mechanism is still obscure. The gene expression of DND1 and survival analyses in PCa were analyzed by the UALCAN database. Expression of DND1 and chloride intracellular channel
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Neoastilbin ameliorates sepsis-induced liver and kidney injury by blocking the TLR4/NF-κB pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2024-02-02 Ruiming Xu, Dawei Wang, Zhengyi Shao, Xiangbo Li, Qiumei Cao
Sepsis frequently causes systemic inflammatory response syndrome and multiple organ failure in patients. Neoastilbin (NAS) is a flavonoid that plays vital functions in inflammation. This work aims to investigate the protective effects of NAS against sepsis-induced liver and kidney injury and elucidate its underlying mechanisms. The mouse model was established using cecal ligation puncture (CLP) induction
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Comprehensive insights into the understanding of hypoxia in ameloblastoma. Histol. Histopathol. (IF 2.0) Pub Date : 2024-02-01 Ronell Bologna-Molina, Lauren Schuch, Sven Eric Niklander
Hypoxia is characterized by a disparity between supply and demand of oxygen. The association between hypoxia and head and neck tumors is a topic of significant interest. Tumors frequently encounter areas with inadequate oxygen supply, resulting in a hypoxic microenvironment. Ameloblastoma is one of the most common benign odontogenic tumors of the maxillofacial region. It is a slow-growing but locally
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In vitro and in vivo antineoplastic activities of solamargine in colorectal cancer through the suppression of PI3K/AKT pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-31 Aihua Liu, Chunying Liu
Previous research has demonstrated the efficacy of SM in inhibiting tumor growth in various cancer types. The objective of this study was to examine the antineoplastic effects and molecular mechanisms of Solamargine (SM) in colorectal cancer.
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Colorectal cancer histopathology image analysis: A comparative study of prognostic values of automatically extracted morphometric nuclear features in multispectral and red-blue-green imagery. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-23 Wenlou Liu, Aiping Qu, Jingping Yuan, Linwei Wang, Jiamei Chen, Xiuli Zhang, Hongmei Wang, Zhengxiang Han, Yan Li
Multispectral imaging (MSI) has been utilized to predict the prognosis of colorectal cancer (CRC) patients, however, our understanding of the prognostic value of nuclear morphological parameters of bright-field MSI in CRC is still limited. This study was designed to compare the efficiency of MSI and standard red-green-blue (RGB) images in predicting the prognosis of CRC.
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GNA15 facilitates the malignant development of thyroid carcinoma cells via the BTK-mediated MAPK signaling pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-19 Yihan Sun, Yifan Han
G protein subunit alpha 15 (GNA15) is recognized as an oncogene for some cancers, however, its role in thyroid carcinoma (TC) is elusive and is investigated in this study. Concretely, bioinformatics was employed to analyze the GNA15 expression profile in TC. The effect of GNA15 on TC cell functions was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation
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The multiple facets of the club cell in the pulmonary epithelium. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-18 Nelly López-Valdez, Marcela Rojas-Lemus, Patricia Bizarro-Nevares, Adriana González-Villalva, Brenda Casarrubias-Tabarez, María Eugenia Cervantes-Valencia, Martha Ustarroz-Cano, Guadalupe Morales-Ricardes, Shamir Mendoza-Martínez, Gabriela Guerrero-Palomo, Teresa I Fortoul
The non-ciliated bronchiolar cell, also referred to as "club cell", serves as a significant multifunctional component of the airway epithelium. While the club cell is a prominent epithelial type found in rodents, it is restricted to the bronchioles in humans. Despite these differences, the club cell's importance remains undisputed in both species due to its multifunctionality as a regulatory cell in
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Localization of advanced glycation end-products and their receptor in tendinopathic lesions. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-17 Eva Asomugha, Young Cho, Sharada Paudel, Yi Guo, Lew Schon, Zijun Zhang
This study was designed to investigate the accumulation of advanced glycation end-products (AGEs) and the expression of the receptor of AGEs (RAGE) in tendinopathic tissues. In this study, tendinopathic posterior tibial tendons (PTT) were collected from patients (n=6). Redundant autografts of flexor digitorum longus tendon (FDL; n=3) were used for controls. The control and tendinopathic tendon tissues
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Role of INPP4B in the proliferation, migration, invasion, and survival of human endometrial cancer cells. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-16 Jing Zhao, Xue-Mei Du, Wen Si, Xian-He Zhao, Zi-Qi Zhou
Inositol polyphosphate 4-phosphatase type II (INPP4B) has been identified as a tumor repressor in several human cancers while its role in endometrial cancer has not been investigated yet. Therefore, the current study was designed to determine whether INPP4B participates in the progression of endometrial cancer by utilizing clinical data and experimental determination.
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Role of mitochondria in neonatal hypoxic-ischemic encephalopathy. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-15 Weijing Kong, Cheng Lu
Neonatal hypoxic-ischemic encephalopathy, an important cause of death as well as long-term disability in survivors, is caused by oxygen and glucose deprivation, and limited blood flow. Following hypoxic-ischemic injury in the neonatal brain, three main biochemical damages (excitotoxicity, oxidative stress, and exacerbated inflammation) are triggered. Mitochondria are involved in all three cascades
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Genotype-histotype-phenotype correlations in hyperinsulinemic hypoglycemia. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-12 Annette Rønholt Larsen, Klaus Brusgaard, Henrik Thybo Christesen, Sönke Detlefsen
Hyperinsulinemic hypoglycemia (HH) of pancreatic origin includes congenital hyperinsulinism (CHI), insulinoma, insulinomatosis, and adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia syndrome (NI-PHHS). In this review, we describe the genotype-histotype-phenotype correlations in HH and their therapeutic implications. CHI can occur from birth or later on in life. Histologically, diffuse
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Quantification of eosinophils in the lower gastrointestinal tract of adults: a review of surgical specimens with normal histology from the Free State province, South Africa. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-11 Jane E Duncan, Gina Joubert, Jacqueline Goedhals
Eosinophils are normal residents of the gastrointestinal tract (GIT). They are noted in small numbers with significant variation between anatomic locations. An idiopathic increase of eosinophils is known as eosinophilic gastrointestinal disease (EGID). EGIDs are a heterologous group of disorders that produce a range of enteric and colonic syndromes. Their incidence has been increasing worldwide. Our
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Altered expression of the Plexin-B2 system in tuberous sclerosis complex and focal cortical dysplasia IIb lesions. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-10 Lu Dai, Jun Huang, Kai-Feng Shen, Xiao-Lin Yang, Gang Zhu, Li Zhang, Zhong-Ke Wang, Shi-Yong Liu, Xiang Liao, Sen-Lin Xu, Hui Yang, Xing-Yi Li, Chun-Qing Zhang
Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) type IIb are the predominant causes of drug-refractory epilepsy in children. Dysmorphic neurons (DNs), giant cells (GCs), and balloon cells (BCs) are the most typical pathogenic profiles in cortical lesions of TSC and FCD IIb patients. However, mechanisms underlying the pathological processes of TSC and FCD IIb remain obscure. The
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Rapamycin mitigates organ damage by autophagy-mediated NLRP3 inflammasome inactivation in sepsis. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-09 Xiaofeng Li, Qingqiu Zeng, Rui Yao, Lingyan Zhang, Ying Kong, Bin Shen
Autophagy activation can alleviate sepsis-induced organ injuries. Rapamycin (Rap) has emerged as an autophagy regulator in multiple forms of organ injuries. This study aimed to assess whether Rap protects rats from cecal ligation and puncture (CLP)-induced sepsis through autophagy-mediated inactivation of the NLRP3 inflammasome. Rats were allocated to the sham, CLP, Rap (10 mg/kg), or 3-Methyladenine
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Targeting PEAK1 sensitizes anaplastic thyroid carcinoma cells harboring BRAFV600E to Vemurafenib by Bim upregulation. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-08 Qiuhan Wang, Fengyun Hao, Liang Ning, Chong Sun
Pseudopodium-enriched atypical kinase 1 (PEAK1) has been demonstrated to be upregulated in human malignancies and cells. Enhanced PEAK1 expression facilitates tumor cell survival and chemoresistance. However, the role of PEAK1 inhibition to anaplastic thyroid carcinoma cell (ATC) and vemurafenib resistance is still unknown. Here, we observed that targeting PEAK1 inhibited cell viability and colony
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Astragaloside IV induces endothelial progenitor cell angiogenesis in deep venous thrombosis through inactivation of PI3K/AKT signaling. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-05 Xiaojiang Lyu, Zhigang Yi, Yun He, Chunfeng Zhang, Ping Zhu, Chonghai Liu
Deep vein thrombosis (DVT), referred to as venous thromboembolism, is the third most frequent cardiovascular disease. Endothelial progenitor cells (EPCs) contribute to the recanalization of DVT. Astragaloside IV (AS-IV) has been suggested to have angiogenesis-enhancing effects. Here, we investigate the roles and mechanisms of AS-IV in EPCs and DVT.
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Transcription factor YY1 accelerates hepatic fibrosis development by activating NLRP3 inflammasome-mediated pyroptosis. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-04 Xiao Fu, Ping Xiao, Xin Luo, Ninghong Guo
Hepatic fibrosis is the basis of multiple liver diseases and may eventually develop into hepatocellular carcinoma. Hepatic stellate cell (HSC) activation is a driving factor of hepatic fibrogenesis. In the liver microenvironment, liver cells and others play a crucial role in HSC activation. The liver tissues of CCl4-induced rats show excessive fibrosis, inflammation, and cell apoptosis. Yin Yang 1
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Heraclenin promotes the osteogenic differentiation of bone marrow stromal cells by activating the RhoA/ROCK pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-03 Zuguang Yu, Jun Yuan, Yuanyuan Yu
Osteoporosis is a devastating skeletal disease, the pathogenesis of which is related to abnormal bone metabolism, featured by the imbalance between osteoblastic bone formation and osteoclastic bone resorption. Stem cell-based therapies have been demonstrated to improve osteoporosis treatment. Previously, the linear furanocoumarin heraclenin was reported to enhance osteoblast differentiation and mineralization
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Expression of the HIF-1α/VEGF pathway is upregulated to protect alveolar bone density reduction in nasal-obstructed rats. Histol. Histopathol. (IF 2.0) Pub Date : 2024-01-02 Zishan Liu, Yongming Li
Hypoxia and mouth breathing are closely related to maxillofacial bone metabolism and are characteristic of obstructive sleep apnea-hypopnea syndrome (OSAHS). Being key factors in the hypoxia response, hypoxia-inducible factor 1α (HIF-1α) and HIF-responsive gene vascular endothelial growth factor (VEGF) are essential for bone remodeling. This study focuses on the role of the HIF-1α/VEGF pathway in alveolar
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Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-29 Miguel A Ortega, Laura Jiménez-Álvarez, Oscar Fraile-Martinez, Cielo Garcia-Montero, Diego De León-Oliva, María Del Val Toledo-Lobo, Esther Palacios, Paula Granado, Alfonso Esteban, Luis G Guijarro, Leonel Pekarek, Ángel Asúnsolo, Laura López-González, Julia Bujan, Natalio García-Honduvilla, Melchor Álvarez-Mon, Miguel A Saez, Raúl Díaz-Pedrero
Pancreatic cancer is a highly lethal malignancy with a growing incidence reported worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, which is often diagnosed at advanced stages, making its prognosis and medical management difficult. The identification of histopathological biomarkers has allowed a more precise stratification of pancreatic cancer patients
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Molecular changes underlying pulmonary emphysema and chronic bronchitis in Chronic Obstructive Pulmonary Disease: An updated review. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-28 Elia A Baltazar-García, Belinda Vargas-Guerrero, Luz E Gasca-Lozano, Carmen M Gurrola-Díaz
The aim of this review is to update and synthesize the molecular mechanisms that lead to the heterogeneous effect on tissue remodeling observed in the two most important clinical phenotypes of chronic obstructive pulmonary disease (COPD), pulmonary emphysema (PE) and chronic bronchitis (CB). Clinical and experimental evidence suggests that this heterogeneous response to promote PE, CB, or both, is
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Impact of maternal stress on metabolism and penile morphology in young offspring rats. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-27 Carolinne Macedo, Juliana Monnerat, Bianca Lucchetti, Gabriel Teixeira, Juliana Mentzinger, Helena Rocha, Renata Medeiros, Natália Rocha, Diogo de Souza, Francisco Sampaio, Bianca Gregorio
Exposure to prolonged stress in pregnancy and/or lactation can lead to the future development of diseases. We aimed to study the effects of maternal stress on the biometry, metabolism, and penile morphology of young Wistar rats. Animals were divided into two experimental groups: Control Group (C) - pups from control mothers, without any intervention (n=5); and Chronic Stress Group (S) - pups from mothers
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Expression and hypermethylation of JAM and EPB41L3 in cervical squamous cell carcinoma: Clinical significance and applications. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-26 Yun Gu, Chengzhuo Chu, Bei Yuan, Jiandong Wang, Shiyang Pan
This study aimed to explore the expression and hypermethylation of EPB41L3 and JAM3 in cervical squamous cell carcinoma (CSCC) and to investigate their clinical significance. JAM3 and EPB41L3 mRNA expression was analyzed using a public database, and protein expression was detected using immunohistochemistry. The methylation status of JAM3 and EPB41L3 was detected in CSCC tissues and cervical cytological
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Melan-A expression in non-melanocytic carcinoma: A potential diagnostic pitfall. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-22 Linwei Zuo, Huiyan You, Zhe Cai, Shousheng Liao, Xiangtong Lu, Lixiang Li, Wenyong Huang
Melan-A/MART-1 is a melanocytic differentiation marker recognized as an antigen on melanoma cells. It is a useful diagnostic marker for pathologists in the diagnosis of melanocytic tumors. However, we recently found that Melan-A can be expressed in some non-melanocytic carcinomas that are rarely reported in the literature.
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Identification and validation of plasma AGRN as a novel diagnostic biomarker of hepatitis B Virus-related chronic hepatitis and liver fibrosis/cirrhosis. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-21 Rong Ai, Lu Li, Xiwei Yuan, Dandan Zhao, Tongguo Miao, Weiwei Guan, Shiming Dong, Chen Dong, Yao Dou, Mengmeng Hou, Yuemin Nan
The aim of this study was to find novel biomarkers and develop a non-invasive, effective diagnostic model for hepatitis B Virus-related chronic hepatitis and liver fibrosis/cirrhosis.
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An overview of chemically induced rodent models for sporadic colorectal cancer: Histopathological and translational perspectives. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-18 Luis Manuel Sarmiento-Machado, Maria Aparecida Marchesan Rodrigues, Guilherme Ribeiro Romualdo, Luís Fernando Barbisan
Globally, colorectal cancer (CRC) is one of the most frequently diagnosed human gastrointestinal neoplasia and the second leading cause of cancer-related death in both men and women. Despite considerable efforts currently devoted to the study of the biology and treatment of CRC, patient prognosis and survival are still poor. Sporadic CRC is a complex multistep disease and usually emerges in the setting
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Annexin-A1 short peptide alleviates septic myocardial injury by upregulating SIRT3 and inhibiting myocardial cell apoptosis. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-15 Song Qin, Yingcong Ren, Banghai Feng, Xiaoqin Wang, Junya Liu, Jie Zheng, Kang Li, Hong Mei, Qiuyu Dai, Hong Yu, Xiaoyun Fu
Septic myocardial injury is a common complication of severe sepsis, which occurs in about 50% of cases. Patients with this disease may experience varying degrees of myocardial damage. Annexin-A1 short peptide (ANXA1sp), with a molecular structure of Ac-Gln-Ala-Tyr, has been reported to exert an organ protective effect in the perioperative period by modulating sirtuin-3 (SIRT3). Whether it possesses
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Autoimmune hepatitis with confluent necrosis indicates severe liver injury but responds well to standard immunosuppressive therapy. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-14 Xiaoyi Sun, Yu Su, Aileen Wee, Jimin Liu, Qianyi Wang, Jingqi Zhang, Xinyan Zhao, Jidong Jia
We aimed to study the effects of different extensive confluent necrosis on complete biochemical remission, side effects of immunosuppressants, and outcomes in patients with autoimmune hepatitis (AIH). Patients with liver biopsy, receiving standard immunosuppressive therapy (IST), and regular follow-up were retrospectively recruited. Demographic and clinicopathological characteristics between Ishak
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Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-13 Stephen Safe
Although endogenous ligands for the orphan nuclear receptor 4A1 (NR4A1, Nur77), NR4A2 (Nurr1), and NR4A3 (Nor-1) have not been identified, several natural products and synthetic analogs bind NR4A members. These studies are becoming increasingly important since members of the NR4A subfamily of 3 receptors are potential drug targets for treating cancer and non-cancer endpoints and particularly those
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Inflammatory suppression and immunity regulation benefits of honokiol in a rat model of acute peritonitis via the regulation of NLRP3 inflammasome and Sirt1/autophagy axis. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-12 Ximing Pan, Zhou Hua, Guocai Fan, Qinglong Feng
NLRP3 inflammasome and Sirt1/autophagy axis are potential targets for advancing acute peritonitis (AP). Honokiol (HNK), a bioactive substance, has the potential to improve AP.
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Differential roles of serotonin receptor subtypes in regulation of neurotrophin receptor expression and intestinal hypernociception. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-11 Meng-Ping She, Yu-Ting Hsieh, Li-Yu Lin, Chia-Hung Tu, Ming-Shiang Wu, Ling-Wei Hsin, Linda Chia-Hui Yu
Aberrant serotonin (5-hydroxytryptamine, 5-HT) metabolism and neurite outgrowth were associated with abdominal pain in irritable bowel syndrome (IBS). We previously demonstrated that 5-HT receptor subtype 7 (5-HT₇) was involved in visceral hypersensitivity of IBS-like mouse models. The aim was to compare the analgesic effects of a novel 5-HT₇ antagonist to reference standards in mouse models and investigate
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Median nerve electrical stimulation improves traumatic brain injury by reducing TACR1 to inhibit nuclear factor-κB and CCL7 activation in microglia. Histol. Histopathol. (IF 2.0) Pub Date : 2023-12-07 Fan Sun, Wenbing Liu, Xiaodong Li, Xiaowei Wang, Yali Ou, Xuesong Li, Min Shi
The existing report elucidates that median nerve electrical stimulation (MNS) plays a role in treating traumatic brain injury (TBI). Herein, we explored the mechanism of MNS in TBI. A TBI-induced coma model (skull was hit by a cylindrical impact hammer) was established in adult Sprague-Dawley rats. Microglia were isolated from newborn Sprague-Dawley rats and was injured by lipopolysaccharide (LPS;
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Clinicopathological analysis of bronchiolar adenoma combined with lung adenocarcinoma: Report of eight cases and literature review. Histol. Histopathol. (IF 2.0) Pub Date : 2023-11-29 Minsheng Zhu, Qianqian Yang, Shenghua Zhan, Weishuo Liu, Wei Liu, Lingchuan Guo, Shan Huang
To investigate the clinicopathological characteristics and potential diagnostic pitfalls of bronchiolar adenoma (BA) combined with lung adenocarcinoma (LUAD) in the same lesion.
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Region-specific response of central microglial cells to sciatic nerve demyelination through sensory and motor pathways. Histol. Histopathol. (IF 2.0) Pub Date : 2023-11-28 Shuang Wu, Yuxin Su, Yuqing Wang, Jia Wang, Dongsheng Xu, Yihan Liu, Kunwu Yang, Junhong Gao, Jingjing Cui, Wanzhu Bai
Peripheral nerve injury can cause changes in microglial cells on the spinal dorsal and ventral horns. This region-specific response implies that central microglial cells could be activated through both sensory and motor pathways. In order to further determine how peripheral nerve injury activates central microglial cells through neural pathways, the sciatic nerve was selected as the target for neural
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CBP-mediated FOXO4 acetylation facilitates postmenopausal osteoporosis (PMO) progression through the inhibition of the Wnt/β-catenin signaling pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2023-11-27 Qiubo Huang, Jiang Wang
FOXO4 was previously identified as a potential biomarker and therapeutic target for postmenopausal osteoporosis (PMO) using bioinformatic analysis, but its specific function and molecular mechanism in the progression of osteoporosis was not reported. The current study was designed to investigate the biological function and underlying mechanism of FOXO4 in PMO. Our results showed that FOXO4 expression
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Mechanism of Weiwei granules in the treatment of chronic active Helicobacter pylori gastritis with atrophy based on the TLR4/NF-κB/COX-2 inflammatory signaling pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2023-11-23 Haipeng Zhang, Hongyan Liu
Our paper aimed to elucidate the mechanism of Weiwei granules in the treatment of Helicobacter pylori (Hp)-positive chronic atrophic gastritis (CAG) based on the TLR4/NF-κB/COX-2 inflammatory signaling pathway.
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ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma. Histol. Histopathol. (IF 2.0) Pub Date : 2023-11-22 Yong Yang, Wei Xie, Xuan Qiao, Jun Yang, Dan Yao, Dongming Zhu
Lysosomal-associated transmembrane protein 5 (LAPTM5) has been associated with poor prognosis in cancer patients. Its role in regulating metastasis in pancreatic ductal adenocarcinoma (PDAC), however, remains vague. The study here aimed to expound the metastasis-promoting properties of LAPTM5 in PDAC and the detailed mechanism. LAPTM5 was overexpressed in metastatic PDAC cells and was related to the
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Ethyl acetate extracted from the chinese medicinal plant Caesalpinia sappan L alleviates gustatory response in diabetes mellitus rats. Histol. Histopathol. (IF 2.0) Pub Date : 2023-11-20 Xun Cao, Li Cui, Wen Yang
The critical role of ethyl acetate (EtOAc) extracts of Caesalpinia sappan L (C. sappan) in disease control has been studied, while its potential function in diabetes mellitus (DM)-induced gustatory response remains unclear. Here, we focused on the regulatory role of EtOAc extracts of C. sappan in taste-regulatory peptides in vallate papillae and the hypothalamus.
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Podocyte involvement in the pathogenesis of preterm-related long-term chronic kidney disease. Histol. Histopathol. (IF 2.0) Pub Date : 2023-11-15 Lulu Zhang, Jun Zheng, Fangrui Ding
With the continuous advancement of neonatal intensive care technology, the survival rate of preterm infants is gradually increasing. However, this improvement in survival is accompanied by long-term prognostic implications in various systems. In the field of renal diseases, current epidemiological data indicate that preterm birth is a significant risk factor for the development of long-term chronic
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Nasopharyngeal carcinoma with non-squamous phenotype may be a variant of nasopharyngeal squamous cell carcinoma after inhibition of EGFR/PI3K/AKT/mTOR pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2023-11-08 Jiahe Wang, Yifan Shang, Yujiao Wang, Ye Li, Lei Wang, Sixia Huang, Xinquan Lyu
Nasopharyngeal carcinoma (NPC) is a cancerous tumor that develops in the nasopharynx epithelium and typically has squamous differentiation. The squamous phenotype is evident in immunohistochemistry, with diffuse nuclear positivity for p63 and p40. Nonetheless, a few NPCs have been identified by clinicopathological diagnosis that do not exhibit the squamous phenotype; these NPCs are currently referred
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The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role. Histol. Histopathol. (IF 2.0) Pub Date : 2023-09-27 Jia Han, Tohru Itoh, Akihiro Shioya, Masaru Sakurai, Takeru Oyama, Motona Kumagai, Hiroyuki Takamura, Masashi Okuro, Tsuyoshi Mukai, Hidekazu Kitakata, Masaru Inagaki, Michiyo Higashi, Xin Guo, Sohsuke Yamada
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor prognosis. Therefore, indicators that can be used for the early prediction of the prognosis of PDAC are needed. Peroxiredoxin (PRDX) 4 is a secretion-type antioxidant enzyme located in the cytoplasmic endoplasmic reticulum. Recent studies have reported that it is closely related to the development and prognosis of many types of cancer
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Selenomethionine suppresses head and neck squamous cell carcinoma progression through TopBP1/ATR and TCAB1 signaling. Histol. Histopathol. (IF 2.0) Pub Date : 2023-09-11 Bo Zhang, Xiaodong Wei, Jiwu Li
Head and neck squamous cell carcinoma (HNSCC) is a histological type of cancer originating from the head and neck. Selenium complexes have been considered as a potential treatment for HNSCC. Therefore, the present work focused on probing the mechanism of L-selenomethionine (SeMet) in HNSCC treatment.
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Bioceramic versus traditional biomaterials for endodontic sealers according to the ideal properties. Histol. Histopathol. (IF 2.0) Pub Date : 2023-09-08 Miguel A Ortega, Laura Rios, Oscar Fraile-Martinez, Diego Liviu Boaru, Diego De Leon-Oliva, Silvestra Barrena-Blázquez, Claude Pereda-Cerquella, Maria J Garrido-Gil, Luis Manteca, Julia Bujan, Natalio García-Honduvilla, Cielo García-Montero, Antonio Rios-Parra
Odontology, as a scientific discipline, continuously collaborates with biomaterials engineering to enhance treatment characteristics and patients' satisfaction. Endodontics, a specialized field of dentistry, focuses on the study, diagnosis, prevention, and treatment of dental disorders affecting the dental pulp, root, and surrounding tissues. A critical aspect of endodontic treatment involves the careful
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Prognostic impact of mitosis and necrosis in non-mucinous lung adenocarcinomas and correlation with IASLC grading system. Histol. Histopathol. (IF 2.0) Pub Date : 2023-09-05 Gürdenız Serın, Pinar Savaş, İrem Şahver İşgör, Alı Özdıl, Alı Mizrak, Alı Veral, Denız Nart
In 2020, the International Lung Cancer Study Group (IASLC) Pathology Committee established a grading system for non-mucinous primary lung adenocarcinomas. This grading system is based on whether areas of high-grade patterns are present in more than 20% of the tumor. Parameters, such as necrosis, mitotic activity, lymphovascular invasion (LVI) and spread through air spaces (STAS), are excluded from
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Heterogeneity of mesenchymal cells in human amniotic membrane at term. Histol. Histopathol. (IF 2.0) Pub Date : 2023-09-04 Salvador Cortes, Vicente Seco-Rovira, Ester Beltrán-Frutos, María I Serrano-Sánchez, Jesús Martínez-Hernández, Concepción Ferrer, Juan L Delgado, Carmen L Insausti, Miguel Blanquer, Luis M Pastor
There is increasing interest in understanding the tissue biology of human amniotic membrane (hAM) given its applications in medicine. One cellular component is mesenchymal cells, which can be extracted, cultured and differentiated "in vitro" into various cell types. These studies show that there is heterogeneity among mesenchymal cells. The aim of this work is to study the membrane "in situ" to determine
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miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under the treatment of Tetrandrine. Histol. Histopathol. (IF 2.0) Pub Date : 2023-08-04 Min Wang, Kai Liu, Zhongming Zhou, Huizhuan Geng
The interaction of miRNAs with Chinese herbal medicines is a promising therapeutic approach for prevention of cervical cancer.
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Cold-shock proteins accumulate in centrosomes and their expression and primary cilium morphology are regulated by hypothermia and shear stress. Histol. Histopathol. (IF 2.0) Pub Date : 2023-08-03 María Díaz de Cerio, Sara Oliván, Ignacio Ochoa, Josune García-Sanmartín, Alfredo Martínez
Primary cilia act as cellular sensors for multiple extracellular stimuli and regulate many intracellular signaling pathways in response. Here we investigate whether the cold-shock proteins (CSPs), CIRP and RBM3, are present in the primary cilia and the physiological consequences of such a relationship. R28, an immortalized retinal precursor cell line, was stained with antibodies against CIRP, RBM3
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Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay. Histol. Histopathol. (IF 2.0) Pub Date : 2023-07-31 Suad Ak Shamis, Francesca Savioli, Aula Ammar, Sara Sf Al-Badran, Phimmada Hatthakarnkul, Holly Leslie, Elizabeth Ea Mallon, Nigel B Jamieson, Donald C McMillan, Joanne Edwards
Prognostic significance and gene signatures associated with carbonic anhydrase IX (CAIX) was investigated in triple negative breast cancer (TNBC) patients.
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Up-regulation of Trim28 in pregnancy-induced hypertension is involved in the injury of human umbilical vein endothelial cells through the p38 signaling pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2023-07-21 Min Chen, Peng Shi, Ping Wang, Tingting Zhang, Jing Zhao, Li Zhao
The present study is to analyze the regulation and potential molecular mechanism of Trim28 on vascular endothelial injury induced by pregnancy-induced hypertension (PIH).
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Submucosal gland differentiation and implications in esophageal basaloid squamous cell carcinomas. Histol. Histopathol. (IF 2.0) Pub Date : 2023-06-27 Ling Nie, Tingting Chen, Hongyan Wu, Muhan Ni, Leying Zhou, Xiangshan Fan, Xiaobin Cui, Qi Sun
Esophageal basaloid squamous cell carcinoma (BSCC) is a heterogenous entity with multilineage differentiation. It lacks systematical analysis on submucosal gland differentiation (SGD) due to the histological diversity and low incidence of esophageal BSCC. This study aims to find the correlation of SGD and clinicopathological features. A total of 152 esophageal BSCCs were separated into three histological
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TRIM11 expression in non-small cell lung cancer is associated with poor prognosis. Histol. Histopathol. (IF 2.0) Pub Date : 2023-06-26 Christiane Kuempers, Tobias Jagomast, Finn-Ole Paulsen, Carsten Heidel, Sabine Bohnet, Stefanie Schierholz, Markus Reischl, Eva Dreyer, Till Olchers, Martin Reck, Jutta Kirfel, Sven Perner
Despite promising results of targeted therapy approaches, non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death. Tripartite motif containing 11 (TRIM11) is part of the TRIM family of proteins, playing crucial roles in tumor progression. TRIM11 serves as an oncogene in various cancer types and has been reported to be associated with a poor prognosis. In this study, we
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Research progress on the correlation between platelet aggregation and tumor progression. Histol. Histopathol. (IF 2.0) Pub Date : 2023-06-23 Yuyu Chen, Jialong Yuan, Faqing Tang, Qinglin Liu, Hongjun Huang, Huan Liu, Hao Liu
Platelets are generally considered as the main functional unit of the coagulation system. However, more and more studies have confirmed that platelets also have an important relationship with tumor progression. Tumor cells can utilize platelets to promote their own infiltration and hematogenous metastasis, and platelets are activated and aggregated in this process. Therefore, platelet aggregation may
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Helicobacter pylori vacA affects the expression of COX-2 in the duodenal mucosa of patients with duodenitis. Histol. Histopathol. (IF 2.0) Pub Date : 2023-06-22 Yan Chu, Fengyuan Chen, Qincong Pan, Nuo Cheng, Xiuping Liu, Jie Feng
Duodenitis refers to inflammation that occurs in the duodenum. Helicobacter pylori (Hp) is a known risk factor for duodenitis. This paper attempted to analyze the correlation between Hp virulence genotypes and the initiation and development of duodenal bulbar inflammation (DBI) to lay the foundation for the management of duodenitis induced by Hp infection. Total RNA was extracted from duodenal samples
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Eupatilin alleviates inflammation and epithelial-to-mesenchymal transition in chronic rhinosinusitis with nasal polyps by upregulating TFF1 and inhibiting the Wnt/β-catenin signaling pathway. Histol. Histopathol. (IF 2.0) Pub Date : 2023-06-07 Hongxia Su, Yulin Zhao
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease characterized by high prevalence and morbidity. However, its pathogenesis is still obscure. This work focuses on the effects of Eupatilin (EUP) on inflammation reaction and the epithelial-to-mesenchymal transition (EMT) process in CRSwNP.
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Targeting eIF5A2 reduces invasion and reverses chemoresistance in SCC-9 cells in vitro. Histol. Histopathol. (IF 2.0) Pub Date : 2023-06-06 Jinbo Gao, Peng Li
Eukaryotic translation initiation factor 5A2 (EIF5A2) has been reported to be involved in metastasis and chemotherapy resistance in many human cancers. However, the effect and mechanism of EIF5A2 in oral cancer cells are unknown. Here, we investigated the effects of targeting EIF5A2 on chemotherapy resistance in oral cancer cells in vitro.
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Calpain-specific breakdown fragment in human drusen. Histol. Histopathol. (IF 2.0) Pub Date : 2023-06-01 Kana Orihara, Momoko Kobayashi-Otsugu, Emi Nakajima, Ryan D Walkup, David J Wilson, Thomas R Shearer, Mitsuyoshi Azuma
With aging and age-related macular dystrophy (AMD), proteolytic fragments are deposited in extracellular drusen located between the RPE and Bruch's membrane. Localized hypoxia may be a risk factor for AMD. Our hypothesis is that following hypoxia, activation of proteolytic enzymes called calpains may cause proteolysis/degeneration of retinal cells and RPE. No direct evidence has yet demonstrated activation