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Modulatory Effects of Moringa Oleifera Leaf Extract on Sodium Nitrate-Induced Experimental Colitis via Regulation of P53, Ki-67 and PCNA Biomarkers Tissue Cell (IF 2.6) Pub Date : 2024-02-25 Hend M. Hassan, Wael M Elsaed, Dina Elzeiny, Ola Ali Habotta, Elshimaa S. Eleraky, Eman Mohamed El Nashar, Mansour Abdullah Alghamdi, Rashid A Aldahhan, Mohammed Attieh Alzahrani, Ali mohni Saleh alamari, Eman Hamza
Ulcerative colitis is a risk factor for colorectal carcinoma. Different mechanisms are related to colitis like apoptosis and hyperproliferation. leaves extract provides a promising option to overcome the risk. To examine the colonic changes in a rat model of colitis induced by sodium nitrate (SN) and study the effects of . Eight adult male rats were allocated in each of the three group; control (distilled
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MRPL21 promotes HCC proliferation through TP53 mutation-induced apoptotic resistance Tissue Cell (IF 2.6) Pub Date : 2024-01-03 Tao Ma, Ya-Bin Huang, Jing Chen, Lu Zhang, Yan-Hua Liu, Cui-Hua Lu
Background and aims The specific mechanisms underlying the inhibition of hepatocellular carcinoma (HCC) proliferation and metastasis by mitochondrial apoptosis are not yet fully understood. However, it plays a vital role in suppressing HCC's ability to proliferate and spread. The involvement of MRPL21, a member within the family of mitochondrial ribosomal proteins (MRPs), is well-documented in both
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Elucidating the mechanism of IL-1β-Mediated Piezo1 expression regulation of chondrocyte autophagy and apoptosis via the PI3K/AKT/mTOR signaling Pathway Tissue Cell (IF 2.6) Pub Date : 2023-12-19 Wanzhuo Chen, Haining Zhang
For the pathogenesis of osteoarthritis (OA), the classical view is that chondrocyte apoptosis is associated with and may cause age-related joint degeneration. Recent observations indicate that Piezo1, a mechanical stress channel expressed in articular cartilage, plays a crucial role in this process. We wanted to investigate whether other conditions activate the expression of Piezo1 in chondrocytes
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Ivermectin prevents stress-induced testicular damage in juvenile rats Tissue Cell (IF 2.6) Pub Date : 2023-12-20 Nathalia A. Galvão, Flora Cordeiro, Maria M. Bernardi, Thiago B. Kirsten
Ivermectin is a popular antiparasitic drug used in veterinary and human medicine. Studies by our group have shown that therapeutic doses of ivermectin induce some brain and behavioral impairments, especially in the reproductive sphere. So far, the studies were focused in adulthood. Considering that juveniles are more susceptible to drugs during developmental stages and both farm/domestic animals and
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Transient receptor potential channel TRPM4 favors oxidized low-density lipoprotein-induced coronary endothelial cell dysfunction via a mechanism involving ferroptosis Tissue Cell (IF 2.6) Pub Date : 2023-12-12 Fengxiang Ye, Dongtao Liu, Junjie Zhang
Accelerating the repair of damaged endothelium can effectively inhibit the progression of atherosclerosis (AS). Transient receptor potential channel TRPM4 is a non-selective cation channel activated by internal Ca2+, which is expressed in endothelial cells. This study aimed to reveal the potential role of TRPM4 in AS along with the mechanism. Human coronary artery endothelial cells (HCAECs) induced
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Tertiary lymphoid structures, a historical reappraisal Tissue Cell (IF 2.6) Pub Date : 2023-12-10 Domenico Ribatti
Tertiary lymphoid structures (TLSs) are accumulations of lymphoid cells within non-lymphoid organs that share the cellular compartments, spatial organization, vasculature, chemokines, and function with secondary lymphoid organs, especially lymph nodes. TLSs are organized into a separate T cell and B cell compartments which contain germinal centers with follicular dendritic cells. In most cases, TLSs
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Zic family member 3 attenuates oxidative stress-induced vascular smooth muscle cell apoptosis in patients with chronic kidney disease Tissue Cell (IF 2.6) Pub Date : 2023-12-08 Jianya Gao, Lei Liu, Zecheng Wu, Hua Gan
Neointimal hyperplasia is reportedly essential for arteriovenous fistulas (AVF) in patients undergoing hemodialysis. Oxidative stress is vital in the progression of uremic venous intimal hyperplasia. Studies have suggested that zinc ions obstruct vascular calcification in patients with chronic kidney disease (CKD). Recent studies have shown that the zinc finger protein, Zic family member 3 (ZIC3),
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In vitro biocompatibility of ammonia-free silver fluoride products on human dental pulp stem cells Tissue Cell (IF 2.6) Pub Date : 2023-12-05 Sergio López-García, José Luis Sanz, Ricardo E. Oñate-Sánchez, Leopoldo Forner, David García-Bernal, Laura Murcia, Francisco J. Rodríguez-Lozano, Carmen Llena
Objectives Silver fluoride (SF) is a preventive and therapeutic option for dental pathological processes involving structural alterations of the hard tissues, either during their formation or those caused by caries or other pathological reasons. This study aimed to compare the biological properties of two commercial SF products, one of them with ammonium (Riva Star; SDF) and the other ammonium-free
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In vitro biocompatibility of ammonia-free silver fluoride products on human dental pulp stem cells Tissue Cell (IF 2.6) Pub Date : 2023-12-05 Sergio López-García, José Luis Sanz, Ricardo E. Oñate-Sánchez, Leopoldo Forner, David García-Bernal, Laura Murcia, Francisco J. Rodríguez-Lozano, Carmen Llena
Objectives Silver fluoride (SF) is a preventive and therapeutic option for dental pathological processes involving structural alterations of the hard tissues, either during their formation or those caused by caries or other pathological reasons. This study aimed to compare the biological properties of two commercial SF products, one of them with ammonium (Riva Star; SDF) and the other ammonium-free
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VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis Tissue Cell (IF 2.6) Pub Date : 2023-12-02 Yuan Liao, Chaonan Deng, Xichuan Wang
Inflammatory bowel disease (IBD) is one of the most common diseases in the digestive system related to aberrant inflammation. V-set and immunoglobulin domain-containing 4 (VSIG4), a type I transmembrane receptor exclusively expressed in a subset of tissue-resident macrophages, has been reported to exert anti-inflammatory activity in immune-related diseases, which has been not explored in IBD yet. This
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Establishment of an immortalized cell line derived from human adenomyosis ectopic lesions Tissue Cell (IF 2.6) Pub Date : 2023-12-01 Zilu Wang, Fengxin Cui, Yinuo Chen, Hongyun Liu, Yiran Zhang, Yaxin Shi, Yinuo Zhang, Yanfei Wang, Li Xu, Ying Liu, Zhiyong Liu, Wei Shi
Because adenomyosis (AM) ectopic primary cells are hard to come by, have a short lifespan, and the characteristics that alter over time, their utility in AM research is constrained. This study aimed to establish a line of immortalized human adenomyosis ectopic cell (ihAMEC) to change this situation. Primary cells were obtained from AM ectopic lesion tissue and then infected with Simian Vacuolating
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Establishment of an immortalized cell line derived from human adenomyosis ectopic lesions Tissue Cell (IF 2.6) Pub Date : 2023-12-01 Zilu Wang, Fengxin Cui, Yinuo Chen, Hongyun Liu, Yiran Zhang, Yaxin Shi, Yinuo Zhang, Yanfei Wang, Na Liang, Li Xu, Ying Liu, Zhiyong Liu, Wei Shi
Because adenomyosis (AM) ectopic primary cells are hard to come by, have a short lifespan, and the characteristics that alter over time, their utility in AM research is constrained. This study aimed to establish a line of immortalized human adenomyosis ectopic cell (ihAMEC) to change this situation. Primary cells were obtained from AM ectopic lesion tissue and then infected with Simian Vacuolating
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The E3 ubiquitin ligase RNF135 modulates chemotherapy resistance to oxaliplatin for colorectal cancer by modulating autophagy Tissue Cell (IF 2.6) Pub Date : 2023-11-30 Zhen Qiu, Shuyan He, Boyi Lu, Yuejun Sun, Ting Zhang, Wei Lv, Dong Shen
Background RING finger protein 135 plays an important role in tumorigenesis and is associated with drug resistance. Methods Bioinformatics analysis showed that RNF135 was significantly differentially expressed in colorectal cancer. RT-qPCR and western blot were used to detect the expression of RNF135. Immunohistochemical analysis were used to measure the expression of RNF135 and Ki-67. Results The
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A review of the therapeutic potential of dental stem cells as scaffold-free models for tissue engineering application Tissue Cell (IF 2.6) Pub Date : 2023-11-25 Elaheh Dalir Abdolahinia, Shayan Golestani, Sepideh Seif, Narges Afra, Khotan Aflatoonian, Ali Jalalian, Nasrin Valizadeh, Elham Dalir Abdollahinia
In the realm of regenerative medicine, tissue engineering has introduced innovative approaches to facilitate tissue regeneration. Specifically, in pulp tissue engineering, both scaffold-based and scaffold-free techniques have been applied. Relevant articles were meticulously chosen from PubMed, Scopus, and Google Scholar databases through a comprehensive search spanning from October 2022 to December
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Engineering an injectable gellan gum-based hydrogel with osteogenesis and angiogenesis for bone regeneration Tissue Cell (IF 2.6) Pub Date : 2023-11-22 Hongbin Liu, Kaihu Li, Bin Guo, Yuhao Yuan, Zhe Ruan, Haitao Long, Jianxi Zhu, Yong Zhu, Can Chen
Injectable hydrogels are currently a topic of great interest in bone tissue engineering, which could fill irregular bone defects in a short time and avoid traditional major surgery. Herein, we developed an injectable gellan gum (GG)-based hydrogel for bone defect repair by blending nano-hydroxyapatite (nHA) and magnesium sulfate (MgSO4). In order to acquire an injectable GG-based hydrogel with superior
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A review of the therapeutic potential of dental stem cells as scaffold-free models for tissue engineering application Tissue Cell (IF 2.6) Pub Date : 2023-11-25 Elaheh Dalir Abdolahinia, Shayan Golestani, Sepideh Seif, Narges Afra, Khotan Aflatoonian, Ali Jalalian, Nasrin Valizadeh, Elham Dalir Abdollahinia
In the realm of regenerative medicine, tissue engineering has introduced innovative approaches to facilitate tissue regeneration. Specifically, in pulp tissue engineering, both scaffold-based and scaffold-free techniques have been applied. Relevant articles were meticulously chosen from PubMed, Scopus, and Google Scholar databases through a comprehensive search spanning from October 2022 to December
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Bone marrow stem cell-derived β-cells: New issue for diabetes cell therapy Tissue Cell (IF 2.6) Pub Date : 2023-11-23 Hadeer A. Aglan, Soheir E. Kotob, Nadia S. Mahmoud, Mohamed S. Kishta, Hanaa H. Ahmed
This investigation aimed to establish the promising role of insulin-producing cells (IPCs) growing from bone marrow-mesenchymal stem cells (BM-MSCs) in relieving hyperglycemia induced in rats. BM-MSCs were differentiated into IPCs using three different protocols. The efficiency of BM-MSCs differentiation into IPCs in vitro was confirmed by detecting IPCs specific gene expression (Foxa-2, PDX-1 and
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Heat shock induces HuR-dependent MKP-1 posttranslational regulation through the p38 MAPK signaling cascade Tissue Cell (IF 2.6) Pub Date : 2023-11-18 Xiao-juan Ma, Zhan Sun, Yi-ping Wang, Xue-ping Yao, Ting-ting Luo, Ya-li Bao, Dina Ainiwaer, Tian Zhang, Hengyi Zhu, Yan Zhang, Fei-ming Hu, Wen-yan Yu
Previous studies demonstrated that phosphatases play a pivotal role in modulating inflammation-associated signal transduction, particularly in the context of heat shock, where Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) appears to have a central role. Recently, Human Antigen R (HuR) has also been identified as a factor that enhances stress-response protein MKP-1 levels. Consequently, we
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RNF144B-mediated p21 degradation regulated by HDAC3 contribute to enhancing ovarian cancer growth and metastasis Tissue Cell (IF 2.6) Pub Date : 2023-11-19 Huiyu Zhuang, Zhiqiang Zhang, Wei Wang, Hong Qu
We have shown before that HDAC3 was involved in the pathogenesis of ovarian cancer; however, the specific mechanism of HDAC3 on the pathogenesis of ovarian cancer has not been thoroughly studied. To explore the related proteins in the mechanism of HDAC3 on ovarian cancer. The transcriptome profiles were identified in ovarian carcinoma cells with HDAC3 knockdown or overexpression. Reverse transcription-quantitative
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PTEN-mediated FOXO signaling affects autophagy, migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes Tissue Cell (IF 2.6) Pub Date : 2023-11-19 Bojie Chen, Fuqiang Wang, Yun Zhang, Fang Liu
Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune disease. Among them, abnormal proliferation, migration and vascularization of fibroblast-like synoviocytes (FLS) are the main pathological basis of persistent synovitis and bone destruction in RA. In the current study, we attempted to find effective molecular mechanisms for the treatment of RA by investigating RA-FLS. Firstly
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Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy Tissue Cell (IF 2.6) Pub Date : 2023-11-14 Wonjun Cho, Heeseung Oh, A.M. Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung
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SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP–SREBP signaling pathway Tissue Cell (IF 2.6) Pub Date : 2023-11-15 Mi-Hua Liu, Xiao-Long Lin, Le-Le Xiao
The sterol regulatory element-binding protein (SREBP) activation and cytokine level were significantly increased in coronavirus disease-19. The NLRP3 inflammasome is an amplifier for cellular inflammation. This study aimed to elucidate the modulatory effect of SARS-CoV-2 nucleocapsid protein (SARS-CoV-2 NP) on trimethylamine N-oxide (TMAO)-induced lipogenesis and NLRP3 inflammasome activation and the
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Corrigendum to “PRMT5-activated c-Myc promote bladder cancer proliferation and invasion through up-regulating NF-κB pathway” [Tissue Cell 76 (2022) 101788] Tissue Cell (IF 2.6) Pub Date : 2023-11-03 Liang Zhang, Guangfeng Shao, Jianhui Shao, Jie Zhao
Abstract not available
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Age-related morphological and ultrastructural changes in the palate and pharyngeal masticatory apparatus of grass carp (Ctenopharyngodon idella) juveniles Tissue Cell (IF 2.6) Pub Date : 2023-11-07 Ahmed M. Abdellatif, Samah Lashen, Ramadan M. Kandyel, Mahmoud B. Shoeib, Fatma A. Madkour
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The role of fenugreek seed extract in alleviating pancreatic toxic effects and altering glucose homeostasis induced by acetamiprid via modulation of oxidative stress, apoptosis, and autophagy Tissue Cell (IF 2.6) Pub Date : 2023-11-05 Samah A. El-Nagdy, Yara M. Elfakharany, Manal Mohammad Morsy, Marwa M. Ahmad, Samaa Salah Abd El-Fatah, Eman El-Sayed Khayal
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DEPDC1B enhances malignant phenotypes of multiple myeloma through upregulating CCNB1 and inhibiting p53 signaling pathway Tissue Cell (IF 2.6) Pub Date : 2023-11-04 Hairong Fei, Xue Shi, Saisai Li, Ying Li, Xiangcong Yin, Zengjie Wu, Wei Wang, Hailei Shi, Ran Li
The identification and investigation of key molecules involved in the pathogenesis of multiple myeloma (MM) hold paramount clinical significance. This study primarily focuses on elucidating the role of DEPDC1B within the context of MM. Our findings robustly affirm the abundant expression of DEPDC1B in MM tissues and cell lines. Notably, DEPDC1B depletion exerted inhibitory effects on MM cell proliferation
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Improvement of rat hepatocellular carcinoma model induced by diethylnitrosamine Tissue Cell (IF 2.6) Pub Date : 2023-11-04 Runzhui Lin, Sitian Xie, Fengjie Xu, Zeming Chen, Jianrui Liu, Xingmu Liu
Objective To construct a new diethylnitrosamine (DEN)-induced rat hepatocellular carcinoma (HCC) model with short induction time, high incidence, and survival rate. Methods 60 male Sprague-Dawley rats were randomly divided into 4 groups: the control group, the model A (MA) group, the model B (MB) group, and the model C (MC) group. The control group was intraperitoneally injected with 0.9% saline for
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Ferulago angulata Extract Alleviates Testicular Toxicity in Male Mice Exposed to Diazinon and Lead Tissue Cell (IF 2.6) Pub Date : 2023-10-29 Nushin Naderi, Manouchehr Souri, Mohammad Hossein Nasr-Esfahani, Mehdi Hajian, Mohammad Naser Nazem
In this study, we investigated the protective effects of Ferulago angulata extract (FAE) against the reproductive toxicants Diazinon (DZN) and Lead (Pb) in mice. These pollutants are known to induce oxidative stress (OS), while FAE acts as a natural antioxidant. Adult male NMRI mice were exposed to DZN, Pb, and DZN+Pb, with or without FAE treatment for six weeks. We evaluated OS markers, testicular
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Skeletal and neurological risks demonstrated in zebrafish due to second-hand cigarette smoke and the neutralization of luteolin Tissue Cell (IF 2.6) Pub Date : 2023-10-27 Gokul Sudhakaran, A.R. Sreekutty, Senthil Subramaniyan, S. Madesh, P. Snega Priya, Raman Pachaiappan, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary, Jesu Arockiaraj
Background Cigarette smoke exposure poses significant health risks, including oxidative stress, inflammation, tissue damage, and neurodegenerative diseases. Luteolin, a natural flavonoid known for its antioxidant and anti-inflammatory properties, is of interest in countering these effects. Aim This study aims to assess luteolin's protective potential against cigarette smoke extract (CSE) in adult zebrafish
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Salvianolic acid B exerts protective effects against Aβ-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1/M2 polarization Tissue Cell (IF 2.6) Pub Date : 2023-10-26 Yuan Zhao, Xin Liu, Xiang Liu, Jian Zhang, Yidan Zhang, Ya Wen, Guofeng Yang
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Decellularized tracheal scaffold as a promising 3D scaffold for tissue engineering applications Tissue Cell (IF 2.6) Pub Date : 2023-10-25 Aida Nahumi, Maryam Peymani, Asadollah Asadi, Arash Abdolmaleki, Yassin Panahi
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Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway Tissue Cell (IF 2.6) Pub Date : 2023-10-24 Ahmet Mentese, Selim Demir, Sevdegul Aydin Mungan, Nihal Turkmen Alemdar, Elif Ayazoglu Demir, Yuksel Aliyazicioglu
Reproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against CP-induced testicular toxicity in rats for the first time. Male Sprague-Dawley rats received a single dose of CP (5 mg/kg; intraperitoneal) and treated with GTA (1.5 and 3 mg/kg; intraperitoneal;
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Exosomes derived from adipose stem cells in combination with hyaluronic acid promote diabetic wound healing Tissue Cell (IF 2.6) Pub Date : 2023-10-21 Huldani Huldani, Iuliia A. Kozlitina, Mesfer Alshahrani, Hamid Mahmood Abdullah Daabo, Sami G. Almalki, Khulood H. Oudaha, Ahmed Hussien Alawadi, Ali Alsalamy, S.K. Joshi, Yasser Fakri Mustafa
Diabetic wound is one of the main challenges in dermatology. Although stem cell-based treatment has therapeutic benefits in wound repair, the clinical application is still limited. Herein we investigated whether adipose stem cells -derived exosomes (Exo) loaded on hyaluronic acid (HA) could promote healing in diabetic rats. Sixty diabetic rats were randomly planned into the control group, Exo group
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UPK1B promoted the invasion and stem cell characteristics of non-small cell lung cancer cells by modulating c-myc/Sox4 axis Tissue Cell (IF 2.6) Pub Date : 2023-10-19 Yiyang Liu, Li Ding, Chunwei Li, Lei Heng, Jianjun Chen, Yulong Hou
Non-small cell lung cancer (NSCLC) is a malignant tumor with extremely high mortality. Uroplakin1B (UPK1B) promotes the occurrence and development of multiple types of cancer by enhancing the expression of c-myc and Sox4. However, whether UPK1B can modulate the development of NSCLC by regulating c-myc/Sox4 axis is unclear. In this study, UPK1B was overexpressed or knocked down in the non-small cell
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Pinostrobin, a dietary bioflavonoid exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against methotrexate-induced ovarian toxicity in rats Tissue Cell (IF 2.6) Pub Date : 2023-10-20 Ling-Ling Zhao, Titilope John Jayeoye, Tolulope Joshua Ashaolu, Opeyemi Joshua Olatunji
This study investigated the protective activities of pinostrobin (PIN) against methotrexate (MTX)-induced ovarian toxicity. Female rats were administered with PIN (50 mg/kg) for 4 weeks, while MTX was administered from weeks 2–4 of PIN treatment. Serum hormonal profiles, ovarian oxidative stress, inflammatory and apoptotic biomarkers as well as ovarian histomorphometry were evaluated. MTX administration
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In situ hybridization analysis of odorant receptor expression in the olfactory organ of the pig-nosed turtle Carettochelys insculpta Tissue Cell (IF 2.6) Pub Date : 2023-10-21 Shoko Nakamuta, Miho Itoh, Masanori Mori, Masanori Kurita, Zicong Zhang, Masato Nikaido, Masao Miyazaki, Takuya Yokoyama, Yoshio Yamamoto, Nobuaki Nakamuta
The turtle olfactory organ consists of upper (UCE) and lower (LCE) chamber epithelium, which send axons to the ventral and dorsal portions of the olfactory bulbs, respectively. Generally, the UCE is associated with glands and contains ciliated olfactory receptor neurons (ORNs), while the LCE is devoid of glands and contains microvillous ORNs. However, the olfactory organ of the pig-nosed turtle Carettochelys
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TNF-α blockage by etanercept restores spatial learning and reduces cellular degeneration in the hippocampus during liver cirrhosis Tissue Cell (IF 2.6) Pub Date : 2023-10-18 Rehab Nady, Rasha R. Ahmed, Nadia Moustafa, Manal Abdul-Hamid
Hepatic encephalopathy (HE) is one of the most debilitating cerebral complications of liver cirrhosis. The one-year survival of patients with liver cirrhosis and severe encephalopathy is less than 50%. Recent studies have indicated that neuroinflammation is a new player in the pathogenesis of HE, which seems to be involved in the development of cognitive impairment. In this study, we demonstrated neurobehavioral
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Lysine demethylase 3A in hypoxic macrophages promotes ovarian cancer development through regulation of the vascular endothelial growth factor A/Akt signaling Tissue Cell (IF 2.6) Pub Date : 2023-10-20 Yan Song, Liming Li, Yan Xi
Background Hypoxia is a vital feature of the tumor microenvironment of OC. Previous evidence exposes that tumor-associated macrophages (TAMs) are connected with the development of ovarian cancer (OC), whereas the accurate regulatory mechanism of hypoxic macrophages regulating tumor advancement remains unclear. Herein, we examined whether the lysine demethylase 3 A (KDM3A) in hypoxic macrophages expedited
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Assessment of breast cytoarchitecture and its associated axillary lymph node status under normal and pathological conditions in Egyptian women Tissue Cell (IF 2.6) Pub Date : 2023-10-15 Omnia Mansour, Amani Kazem, Abeer El Wakil
Objective Herein, we compare the features of neoplastic cancer cells in invasive ductal carcinoma (IDC) grade II and III patients to their corresponding normal cells both in breast and axillary lymph node (ALN) tissues. Methods A retrospective cohort of 70 female breast cancer patients enrolled between 2018 and 2020 at Medical Research Institute, Alexandria University, Egypt, was analyzed for clinicopathological
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The marked dextro-dominance causes accentuated morphophysiological variations in the female reproductive organs of the bat Molossus molossus Tissue Cell (IF 2.6) Pub Date : 2023-10-15 Juliana F. Ferraz, Rodrigo S. de Oliveira, Cornélio S. Santiago, Emília M. Soares, Eliana Morielle-Versute, Sebastião R. Taboga, Mateus R. Beguelini
Molossus molossus is an insectivorous molossid bat that is important in the control of nocturnal insects. It is the nominal and the most representative species of the family. However, there are few studies about its reproduction. Thus, this study aimed to evaluate variations of its female reproductive organs during the different reproductive phases. Twenty adult females, divided into four sample groups
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Evaluating the protective role of trimetazidine versus nano-trimetazidine in amelioration of bilateral renal ischemia/reperfusion induced neuro-degeneration: Implications of ERK1/2, JNK and Galectin-3 /NF-κB/TNF-α/HMGB-1 signaling Tissue Cell (IF 2.6) Pub Date : 2023-10-16 Fatma E. Hassan, Basma Emad Aboulhoda, Isra H. Ali, Heba M. Elwi, Lamiaa M. Matter, Hend Ahmed Abdallah, Mohamed Mansour Khalifa, Asmaa Selmy, Mansour A. Alghamdi, Suzan Awad Morsy, Basant A. Al Dreny
Background Renal ischemia/reperfusion (I/R) is a primary culprit of acute kidney injury. Neurodegeneration can result from I/R, but the mechanisms are still challenging. We studied the implications of bilateral renal I/R on brain and potential involvement of the oxidative stress (OS) driven extracellular signal-regulated kinase1/2, c-Jun N-terminal kinase (ERK1/2, JNK) and Galectin-3 (Gal-3)/nuclear
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Apelin alleviates sepsis-induced acute lung injury in part by modulating the SIRT1/NLRP3 pathway to inhibit endothelial cell pyroptosis Tissue Cell (IF 2.6) Pub Date : 2023-10-19 Manyan Zhang, Jiyu Ning, Yu Lu
Background Sepsis, an intricate systemic inflammatory syndrome, gives rise to various life-threatening complications, with acute lung injury (ALI) being prominently encountered. ALI, clinically characterized by pulmonary infiltration, hypoxemia, and edema, stands as a prevailing consequence of sepsis. This work sought to elucidate the mechanism of Apelin in mitigating sepsis-induced ALI (siALI). Methods
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Streptozotocin- induced changes in aquaporin 1 and 4, oxidative stress, and autophagy in submandibular and parotid salivary glands and the possible ameliorative effect of intermittent fasting on these changes Tissue Cell (IF 2.6) Pub Date : 2023-10-17 Reham Ismail Taha, Mansour Abdullah Alghamdi, , Eman Ali Al Qahtani, Khulood Mohammed Al-Khater, Rashid A. Aldahhan, Eman Mohamad El Nashar
Salivary glands are highly responsible for maintaining oral tissue homeostasis by secreting saliva. This study was designed to investigate aquaporin 1 and 4, oxidative stress, and autophagy in submandibular and parotid salivary glands of diabetic rats and the possible ameliorative effect of intermittent fasting on these changes. Fifty adult male rats were divided into control and experimental groups
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Corrigendum to “Morphological analysis of neck muscle nerves and neurons in cats” [Tissue Cell 82 (2023) 1–11 102077] Tissue Cell (IF 2.6) Pub Date : 2023-10-14 Kazumasa Sasaki, Sei-Ichi Sasaki, Fumi Sato
Abstract not available
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An evaluation of the effects of glabridin and dexamethasone in bleomycin-induced pulmonary fibrosis: The role of BKCa channels Tissue Cell (IF 2.6) Pub Date : 2023-10-15 Elfide Gizem Bakirhan, Ali Parlar
Pulmonary fibrosis is a refractory entity with a progressive course and no effective therapeutic options. The purpose of this study was to investigate the potential involvement of both glabridin and dexamethasone (Dex) in inflammatory and fibrotic responses in a bleomycin (BLM)-induced pulmonary fibrosis model. The role of Ca+2-activated K+ channels (BKCa) in the anti-inflammatory effects of glabridin
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Apoptotic effects of mesenchymal stem cells’ conditioned medium on colorectal cancer cell lines Tissue Cell (IF 2.6) Pub Date : 2023-10-15 Roya Khamooshi, Ali Salimi, Raheleh Halabian, Pardis Saeedi
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Mitochondrial transplantation inhibits cholangiocarcinoma cells growth by balancing oxidative stress tolerance through PTEN/PI3K/AKT signaling pathway Tissue Cell (IF 2.6) Pub Date : 2023-10-14 Xiaocong Liu, Yuanyuan Zhang, Xiaoyan Yang, Yan Zhang, Yulan Liu, Li Wang, Ting Yi, Jing Yuan, Wu Wen, Yi Jian
Background Cholangiocarcinoma (CCA) is a serious threat to human health, and tumor development is associated with abnormal mitochondrial function. It is believed that the introduction of healthy mitochondria into tumor cells can induce the oxidative stress in tumor cells to return to normal levels, thus exerting an inhibitory effect on tumor growth. Methods Mitochondria isolated from 143BρW cells were
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Relationship between long non-coding RNA MALAT1 and HOTAIR expression with sperm parameters, DNA and malondialdehyde levels in male infertility Tissue Cell (IF 2.6) Pub Date : 2023-10-14 Afsaneh-Jaberi Asl, Mohammadreza Sharifi, Abolfazl Dashti, Gholam reza Dashti
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Processing and post-processing of fish skin as a novel material in tissue engineering Tissue Cell (IF 2.6) Pub Date : 2023-10-10 Ali Esmaeili, Azam Rahimi, Amin Abbasi, Behnam Hasannejad-Asl, Saeid Bagheri-Mohammadi, Mohammad Farjami, Saeed Heidari Keshel
As a natural material, fish skin contains significant amounts of collagen I and III, and due to its biocompatible nature, it can be used to regenerate various tissues and organs. To use fish skin, it is necessary to perform the decellularization process to avoid the immunological response of the host body. In the process of decellularization, it is crucial to conserve the extracellular matrix (ECM)
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The role of Wnt signaling in mesenchymal stromal cell-driven angiogenesis Tissue Cell (IF 2.6) Pub Date : 2023-10-12 Pratheesh Mankuzhy, Arun Dharmarajan, Lakshmi R. Perumalsamy, Khan Sharun, Priyanka Samji, Rodney J. Dilley
Development, growth, and remodeling of blood vessels occur through an intricate process involving cell differentiation, proliferation, and rearrangement by cell migration under the direction of various signaling pathways. Recent reports highlight that resident and exogenous mesenchymal stromal cells (MSCs) have the potential to regulate the neovascularization process through paracrine secretion of
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Alleviation of doxorubicin-induced cardiotoxicity in rat by mesenchymal stem cells and olive leaf extract via MAPK/ TNF-α pathway: Preclinical, experimental and bioinformatics enrichment study Tissue Cell (IF 2.6) Pub Date : 2023-10-10 Mahrous A. Ibrahim, Athar M. Khalifa, Noha M. Abd El-Fadeal, Rehab I. Abdel-Karim, Ayman F. Elsharawy, Alia Ellawindy, Heba M. Galal, Eman H. Nadwa, Mohamed A. Abdel-Shafee, Rania A. Galhom
Background Toxic cardiomyopathies were a potentially fatal adverse effect of anthracycline therapy. Aim This study was conducted to demonstrate the pathogenetic, morphologic, and toxicologic effects of doxorubicin on the heart and to investigate how the MAPK /TNF-α pathway can be modulated to improve doxorubicin-Induced cardiac lesions using bone marrow-derived mesenchymal stem cells (BM-MSCs) and
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Every-other day (EOD) feeding regime decreases oxidative stress and inflammatory cascade in mouse liver: The immunohistochemical study Tissue Cell (IF 2.6) Pub Date : 2023-10-06 Katarzyna Piotrowska, Katarzyna Zgutka, Patrycja Tomasiak, Maciej Tarnowski, Andrzej Pawlik
Introduction Positive effects of calorie restrictions (CR) and EOD include decreased body weight, prolonged life span, but also changes in metabolism of the liver. In present paper our aim was to examine antioxidative enzymes: Catalase (CAT) and Manganese superoxidative dismutase (MnSOD, SOD2) and Glutathione peroxidase 4 (Gpx-4) in connection to caspase-3 and inflammatory mediators (IL-1β and TNF-
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GREM1 knockdown regulates the proliferation, apoptosis and EMT of benign prostatic hyperplasia by suppressing the STAT3/c-Myc signaling Tissue Cell (IF 2.6) Pub Date : 2023-10-06 Xiaofei Sun, Minjun Jiang, Zhenfan Wang, Chen Xu, Zheng Ma
Background Gremlin 1 (GREM1) has been reported to be highly expressed in prostate hyperplasia tissues. However, the role and molecular mechanism of GREM1 in benign prostatic hyperplasia (BPH) is still unclear. Methods In this study, expression of GREM1 in BPH-1 cells was detected by western blot assay. Cell counting kit-8 assay was performed to assess cell proliferation. Flow cytometry and western
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Synergistic effects of ozone with doxorubicin on the proliferation, apoptosis and metastatic profile of luminal-B type human breast cancer cell line Tissue Cell (IF 2.6) Pub Date : 2023-10-06 Onur Olgaç Karagülle
Objective Luminal-B type human breast cancer cell line (BT-474) to assess the synergistic effects of ozone applied after chemotherapeutic treatment with various dosages of doxorubicin, and compare the results with the effects on L929 fibroblast cell line. Methods Doxorubicin (1–50 M) was added to each cell lines and left to sit for 24 h at 37 °C. Then, as combination groups, half of the groups were
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Luteolin inhibits angiogenesis and enhances radiotherapy sensitivity of laryngeal cancer via downregulating Integrin β1 Tissue Cell (IF 2.6) Pub Date : 2023-10-06 Zhen Li, Hongzhou Ge, Yonggang Xie, Yueqin Zhang, Xiaoyan Zhao, Wen Sun, Meiyan Song
Aim To demonstrate the role and mechanism of luteolin in radio-sensitization and angiogenesis of laryngeal cancer. Methods Firstly, we analyzed the cytotoxicity of Luteolin and radiation sensitive cytotoxicity through CCK8, and selected subsequent radiation doses and Luteolin concentrations. Next, we further analyzed the effects of Luteolin on radiation sensitivity and neovascularization of laryngeal
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Probiotics mixture and taurine attenuate L-arginine-induced acute pancreatitis in rats: Impact on transient receptor potential vanilloid-1 (TRPV-1)/IL-33/NF-κB signaling and apoptosis Tissue Cell (IF 2.6) Pub Date : 2023-10-06 Marvy G. Mores, Ebtehal Mohammad Fikry, Ahmed O. El-Gendy, Wafaa R. Mohamed, Osama A. Badary
Acute pancreatitis (AP) is an inflammatory disorder of acinar cells. It may develop into severe chronic pancreatitis with a significant mortality rate. The current study aimed to assess the therapeutic effect of a Lactobacillus (LAB) mixture against rat AP. Six groups were created including control, taurine (300 mg/kg; i.p.) for 7 days, LAB mixture for 7 days, L-arginine (2.5 g/kg; i.p.) 2 doses with
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CTRP13 alleviates palmitic acid-induced inflammation, oxidative stress, apoptosis and endothelial cell dysfunction in HUVECs Tissue Cell (IF 2.6) Pub Date : 2023-10-05 Wei Zhu, Guojun Yang, Naijun Chen, Wenjun Zhang, Qian Gao, Tingting Li, Nan Yuan, Huawei Jin
C1q/tumor necrosis factor-related protein 13 (CTRP13) has been reported to participate in cardiovascular diseases. However, the role and molecular mechanism of CTRP13 in obesity-induced endothelial cell damage is still unclear. In palmitic acid (PA)-induced human umbilical vein endothelial cells (HUVECs), qRT-PCR and western blot were used to examine CTRP13 expression. CCK-8 and TUNEL assays were adopted
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Expression of interleukin-1β and its receptor in human granulosa cells and their association with steroidogenesis Tissue Cell (IF 2.6) Pub Date : 2023-09-30 Amir Fattahi, Reza Zarezadeh, Yeganeh Rastgar Rezaei, Liselotte Mettler, Mohammad Nouri, Andreas G. Schmutzler, Ali Salmassi
This study aimed to investigate whether interleukin 1β (IL-1β) and soluble IL-1 receptor 2 (sIL-1R2) are expressed in human granulosa cells (GCs) and relate to ovarian steroidogenesis. Ninety-six women undergoing in vitro fertilization (IVF) were recruited. RT-PCR and immunocytochemistry were used to detect mRNAs and proteins of IL-1β and IL-1R2, respectively. The steroidogenesis of primary cultured
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Quercetin-targeted AKT1 regulates the Raf/MEK/ERK signaling pathway to protect against doxorubicin-induced nephropathy in mice Tissue Cell (IF 2.6) Pub Date : 2023-09-29 Wang Yufang, Liu Mingfang, Huang Nan, Wang Tingting
Background Doxorubicin is an anthracycline antitumor agent commonly used in clinical practice, which has some nephrotoxicity and is often used to establish mouse models of kidney injury for basic medical research. This study will investigate the protective effect of quercetin on renal function in doxorubicin-induced nephropathy mice. Methods C57BL/6 mice were divided into control, model, and quercetin
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Scales of non-avian reptiles and their derivatives contain corneous beta proteins coded from genes localized in the Epidermal Differentiation Complex Tissue Cell (IF 2.6) Pub Date : 2023-09-27 Lorenzo Alibardi
The evolution of modern reptiles from basic reptilian ancestors gave rise to scaled vertebrates. Scales are of different types, and their corneous layer can shed frequently during the year in lepidosaurians (lizards, snakes), 1–2 times per year in the tuatara and in some freshwater turtle, irregularly in different parts of the body in crocodilians, or simply wore superficially in marine and terrestrial