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Copine C plays a role in adhesion and streaming in Dictyostelium Cell Adhes. Migr. (IF 3.2) Pub Date : 2024-02-20 Rodney A. Nichols, Amber D. Ide, Cody T. Morrison, Amber L. Anger, Matthew J. Buccilli, Cynthia K. Damer
Copines are a family of calcium-dependent membrane-binding proteins. To study these proteins, anull mutant for cpnC was created in Dictyostelium, which has six copines genes (cpnA-cpnF). During dev...
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JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties Cell Adhes. Migr. (IF 3.2) Pub Date : 2024-02-15 Yibeini Wu, Yiling Zhao, Ziman Guan, Sajjad Esmaeili, Zhicheng Xiao, Diji Kuriakose
The intensive study and investigation of neuroprotective therapy for central nervous system (CNS) diseases is ongoing. Due to shared mechanisms of neurodegeneration, a neuroprotective approach migh...
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A toolbox to analyze collective cell migration, proliferation and cellular organization simultaneously Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-11-08 Urszula Hohmann, Chalid Ghadban, Julian Prell, Christian Strauss, Faramarz Dehghani, Tim Hohmann
Analyses of collective cell migration and orientation phenomena are needed to assess the behavior of multicellular clusters. While some tools to the authors’ knowledge none is capable to analyze co...
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MST1/2 in inflammation and immunity Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-11-01 Tongfen Li, Yiqiong Wen, Qiongfen Lu, Shu Hua, Yunjiao Hou, Xiaohua Du, Yuanyuan Zheng, Shibo Sun
The mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST...
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Lymphangiogenic responses of lymphatic endothelial cells to steady direct-current electric fields Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-10-27 Linbo Guan, Ping Fan, Yufeng Wang, Xinghui Liu, Rui Liu, Wandi Ma, Huai Bai
Lymphangiogenesis plays pivotal roles in diverse physiological and pathological conditions. Steady direct-current electric fields (DC EFs) induce vascular endothelial behaviors related to angiogene...
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IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-10-09 Qi Li, Yue Li, Fengjiao Wu, Jingyu Li, Zhongsha Li, Xiaoling Qin, Simeng Wei, Chang Chen
The aim of this study was to investigate how the concentration of interleukin-13 (IL-13) affects the regulation of endothelial cell migration after injury. The incubation of recombinant human inter...
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Knockdown of LMNA inhibits Akt/β-catenin-mediated cell invasion and migration in clear cell renal cell carcinoma cells Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-09-25 Hui Xin, Yu Tang, Yan-Hong Jin, Hu-Li Li, Yu Tian, Cong Yu, Ze-Ju Zhao, Ming-Song Wu, You-Fu Pan
The LMNA gene encoding lamin A/C is amplified in some clear cell renal cell carcinoma (ccRCC) samples. Our data showed that depletion of the tumor suppressor PBRM1 can upregulate lamin A/C levels, ...
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Selective adhesion inhibition and hyaluronan envelope reduction of dermal tumor cells by cold plasma-activated medium Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-09-24 Anna-Christin Golz, Claudia Bergemann, Finja Hildebrandt, Steffen Emmert, Barbara Nebe, Henrike Rebl
The sensitivity to cold plasma is specific to tumor cells while leaving normal tissue cells unaffected. This is the desired challenge in cancer therapy. Therefore, the focus of this work was a comp...
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Knockdown of PAF1 reduces cervical cancer cell proliferation, migration and invasion via retarding FLOT2-mediated MEK/ERK1/2 pathway Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-09-27 Bin Tang, Shulan Dou
Cervical cancer (CC) is a very usual reproductive malignant tumor in women. RNA polymerase II-associated factor 1 (PAF1) and flotillin-2 (FLOT2) both have been discovered to key participators in ca...
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Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-09-24 Maha Abedrabbo, Shirel Sloomy, Reham Abu-Leil, Einav Kfir-Cohen, Shoshana Ravid
E-cadherin-catenin complex together with the cytoskeleton, builds the core of Adherens junctions (AJs). It has been reported that Scribble stabilizes the coupling of E-cadherin with catenins promot...
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Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-09-19 Sugan Panneerselvam, Cornelia Wilson, Prem Kumar, Dinu Abirami, Jayakrishna Pamarthi, Mettu Srinivas Reddy, Joy Varghese
Hepatocellular carcinoma (HCC) is the seventh most highly prevalent malignant tumor globally and the second most common cause of mortality. HCC develops with complex pathways that occur through mul...
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A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β2-integrin activation and signaling Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-07-13 Haleigh Conley, Rebecca L. Till, Alix K. Berglund, Samuel L. Jones, M. Katie Sheats
ABSTRACT MARCKS is an actin and PIP2-binding protein that plays an essential role in neutrophil migration and adhesion; however, the molecular details regarding MARCKS function in these processes remains unclear. Neutrophil adhesion and migration also require the cell surface receptors β2-integrins. We hypothesized that MARCKS inhibition would alter neutrophil β2-integrin activation and signaling.
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Inhibition of Integrin αvβ3-FAK-MAPK signaling constrains the invasion of T-ALL cells Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-03-21 Lan Huang, Yao Zhu, Qinglin Kong, Xianmin Guan, Xiaoying Lei, Luying Zhang, Hui Yang, Xinyuan Yao, Shaoyan Liang, Xizhou An, Jie Yu
ABSTRACT The role of adhesion receptor integrin αvβ3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin β3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous system leukemia(CNSL) incidence. Decreasing of cell invasion was observed in Jurkat and Molt4 treated with integrin αvβ3 specific antibody and
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WTAP regulates autophagy in colon cancer cells by inhibiting FLNA through N6-methyladenosine Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-02-27 Liang Huang, Jinfan Shao, Xijuan Xu, Weiwen Hong, Wenfeng Yu, Shuang Zheng, Xiaogang Ge
ABSTRACT Our study investigated the role of WTAP in colon cancer. We employed experiments including m6A dot blot hybridization, methylated RNA immunoprecipitation, dual-luciferase, and RNA immunoprecipitation to investigate the regulatory mechanism of WTAP. Western blot was performed to analyze the expression of WTAP, FLNA and autophagy-related proteins in cells. Our results confirmed the up-regulation
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Cathelicidin LL-37 promotes EMT, migration and metastasis of hepatocellular carcinoma cells in vitro and mouse model Cell Adhes. Migr. (IF 3.2) Pub Date : 2023-01-19 Huidan Zhang, Xueli Yuan, Yaxin Yang, Yangke Wanyan, Liping Tao, Yuqing Chen
ABSTRACT The effect of cathelicidin hCAP18/LL-37 in hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we confirmed that LL-37 expression enhanced endothelial-mesenchymal transition (EMT), migration and invasion in HCC cells. And the HER2/EGFR-MAPK/ERK signal participated in the process above. More frequent lung metastases were observed in an LL-37-overexpressing hematogenous metastasis
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TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-12-13 Yue Zheng, Yuheng Lang, Bingcai Qi, Tong Li
ABSTRACT The migrasomes formation is mediated by the assembly of micron-scale tetraspanin macrodomains and the recruitment of tetraspanin 4 (TSPAN4). However, the physiological functions of TSPAN4 on migrasomes are less known. The TSPAN4 expression in macrophages in single-cell sequencing data, GEO datasets and TCGA database were determined. TSPAN4 expression was highly associated with atherosclerosis
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Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-12-11 Camille Fuselier, Eleonore Dufay, Alexandre Berquand, Christine Terryn, Arnaud Bonnomet, Michael Molinari, Laurent Martiny, Christophe Schneider
ABSTRACT Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of Ruta Graveolens leads to an in vitro inhibition of migration on fibronectin of B16F10 melanoma
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Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-10-06 Junya Ning, Xiaoling Cui, Nan Li, Na Li, Baoxiang Zhao, Junying Miao, Zhaomin Lin
ABSTRACT Hypochlorous acid (HOCl) is an essential signal molecule in cancer cells. Activated GRP78 ATPase by a HOCl probe named ZBM-H inhibits lung cancer cell growth. However, the role and underlying mechanism of GRP78 ATPase in lung cancer cell migration have not been established. Here, we reported that activation of GRP78 ATPase by ZBM-H suppressed A549 cell migration and inhibited EMT process.
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Fluid shear stress induces cell migration via RhoA-YAP1-autophagy pathway in liver cancer stem cells Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-07-26 Zhiping Yan, Danfeng Guo, Ruolin Tao, Xiao Yu, Jiacheng Zhang, Yuting He, Jiakai Zhang, Jie Li, Shuijun Zhang, Wenzhi Guo
ABSTRACT Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC), but the role of the RhoA-YAP1-autophagy pathway in HCC remains unclear. Due to the core role of liver cancer stem cells (LCSCs) in HCC metastasis and recurrence, we explored the RhoA-YAP1-autophagy pathway in LCSCs under FSS. Our results indicate that LCSCs have stronger proliferation and cell spheroidization
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Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-05-26 Su Jin Lee, Ji Eun Kim, Jae Won Jung, Yun Ju Choi, Jeong Eun Gong, Bounleuane Douangdeuane, Onevilay Souliya, Young Whan Choi, Sung Baek Seo, Dae Youn Hwang
ABSTRACT To investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation, alterations to the regulation of focal cell adhesion-related factors were analyzed in NHDF cells and a calvarial defect rat model after treatment with methanol extracts of D. tuberculatus (MED). MED contained gallic acid, caffeic acid, ellagic acid, and naringenin in high concentrations. The proliferation
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Triple-negative and triple-positive breast cancer cells reciprocally control their growth and migration via the S100A4 pathway Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-05-12 Elena A. Dukhanina, Tatiana N. Portseva, Alexander S. Dukhanin, Sofia G. Georgieva
ABSTRACT The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 (TNBC). The proliferative activity of TNBC more than doubled during the incubation in the conditioned medium of TPBC. Extracellular S100A4
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Unravelling cell migration: defining movement from the cell surface Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-05-01 Francisco Merino-Casallo, Maria Jose Gomez-Benito, Silvia Hervas-Raluy, Jose Manuel Garcia-Aznar
ABSTRACT Cell motility is essential for life and development. Unfortunately, cell migration is also linked to several pathological processes, such as cancer metastasis. Cells’ ability to migrate relies on many actors. Cells change their migratory strategy based on their phenotype and the properties of the surrounding microenvironment. Cell migration is, therefore, an extremely complex phenomenon. Researchers
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TNF-α regulates the composition of the basal lamina and cell-matrix adhesions in gingival epithelial cells Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-02-09 Masaru Mezawa, Yuto Tsuruya, Arisa Yamaguchi, Mizuho Yamazaki-Takai, Tetsuro Kono, Hiroyuki Okada, Christopher A. McCulloch, Yorimasa Ogata
ABSTRACT Laminin 5, type 4 collagen, and α6β4 integrin contribute to the formation of hemidesmosomes in the epithelia of periodontal tissues, which is critical for the development and maintenance of the dentogingival junction. As it is not known whether TNF-α alters the composition of the epithelial pericellular matrix, human gingival epithelial cells were cultured in the presence or absence of TNF-α
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Class I Myosins, molecular motors involved in cell migration and cancer Cell Adhes. Migr. (IF 3.2) Pub Date : 2022-01-03 Juan D. Diaz-Valencia, Laura A. Estrada-Abreo, Leonor Rodríguez-Cruz, Alfonso R. Salgado-Aguayo, Genaro Patiño-López
ABSTRACT Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these myosins. Class I Myosins have different functions: regulate membrane tension, participate in endocytosis, exocytosis, intracellular trafficking and cell migration
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Creation and use of organoids in biomedical research and healthcare: the bioethical and metabioethical issues Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-10-28 Henri-Corto Stoeklé, Achille Ivasilevitch, Geneviève Marignac, Christian Hervé
ABSTRACT In the field of bioethics, scientific articles have already been published, and have highlighted relatively pluralist reflections concerning the creation and use of organoids. This plurality, rather than simply reflecting the complexity of the subject, may also be a consequence of the multiple theoretical and practical frameworks applied. Moreover, the creation and use of organoids in biomedical
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P21-activated kinase regulates oxygen-dependent migration of vascular endothelial cells in monolayers Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-09-22 Satomi Hirose, Yugo Tabata, Kazuki Sone, Naoyuki Takahashi, Daisuke Yoshino, Kenichi Funamoto
ABSTRACT The collective migration of vascular endothelial cells plays important roles in homeostasis and angiogenesis. Oxygen concentration in vivo, which is lower than in the atmosphere and changes due to diseases, is a key factor affecting the cellular dynamics of vascular endothelial cells. We previously reported that hypoxic conditions promote the internalization of vascular endothelial (VE)-cadherin
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The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-09-08
ABSTRACT Serotonin is well known as a neurotransmitter. Its roles in neuronal processes such as learning, memory or cognition are well established, and also in disorders such as depression, schizophrenia, bipolar disorder, and dementia. However, its effects on adhesion and cytoskeletal remodelling which are strongly affected by 5-HT receptors, are not as well studied with some exceptions for e.g. platelet
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Directed movement toward, translocation along, penetration into and exit from vascular networks by breast cancer cells in 3D Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-08-02
ABSTRACT We developed a computer-assisted platform using laser scanning confocal microscopy to 3D reconstruct in real-time interactions between metastatic breast cancer cells and human umbilical vein endothelial cells (HUVECs). We demonstrate that MB-231 cancer cells migrate toward HUVEC networks, facilitated by filopodia, migrate along the network surfaces, penetrate into and migrate within the HUVEC
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Role of tight junction-associated MARVEL protein marvelD3 in migration and epithelial–mesenchymal transition of hepatocellular carcinoma Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-08-02
ABSTRACT MarvelD3, a recently identified tight junction membrane protein, could be associated with hepatocellular carcinoma (HCC). We aimed to investigate the role of marvelD3 in Epithelial–Mesenchymal Transition (EMT) and migration of HCC and explore the underlying molecular mechanisms. First, we assessed marvlD3 expression in HCC and normal liver tissues and found loss of marvelD3 expression was
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Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-07-24
ABSTRACT Epithelial damage and increase of intraepithelial mast cells (MC) are characteristics of asthma. The role of MC mediator tryptase and the protease-activated receptor-2 (PAR2) on epithelial wound healing is not fully investigated. Stimulation of bronchial epithelial cells (BECs) with tryptase promoted gap closure, migration and cellular speed compared to controls. Stimulated BECs had higher
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F4, a collagen XIX-derived peptide, inhibits tumor angiogenesis through αvβ3 and α5β1 integrin interaction Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-07-24
ABSTRACT We previously demonstrated that F4 peptide (CNPEDCLYPVSHAHQR) from collagen XIX was able to inhibit melanoma cell migrationin vitro and cancer progression in a mouse melanoma model. The aim of the present work was to study the anti-angiogenic properties of F4 peptide. We demonstrated that F4 peptide inhibited VEGF-induced pseudo-tube formation on Matrigel by endothelial cells and endothelial
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Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-06-22 Francesca Lessi, Paolo Aretini, Milena Rizzo, Mariangela Morelli, Michele Menicagli, Sara Franceschi, Chiara Maria Mazzanti
ABSTRACT MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . An invasion stimulus has been generated through scratches
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Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-06-21 Francesco Roncato, Ofer Regev, Sandeep Kumar Yadav, Ronen Alon
ABSTRACT Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT-stabilizing agent zampanolide (ZMP) in Β16F10 melanoma as amodel of slow-moving cells. ZMP-treated B16 cells failed to follow chemotactic gradients
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Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1 Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-05-30 Luying Li, Youping Jin, Xue Wang, Li Wang, Yangbai Sun, Yihong Luo, Xiaojian Ni, Qi Lu, Wenbo Wei, Xiuling Zhi, Jerry Yu, Wei Zhu, Ping Zhou
ABSTRACT LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of ENST00000508435 was positively correlated with tumor size, lymph node metastasis and HER2. More interesting,
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Role of laminin and cognate receptors in cholangiocarcinoma cell migration Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-05-20 Kittiya Islam, Parichut Thummarati, Pakkanun Kaewkong, Banchob Sripa, Tuangporn Suthiphongchai
ABSTRACT Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell–matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin β4 (ITGB4) in CCA cell lines. Besides, their high expressions in CCA tissues were correlated
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MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-05-06 Begoña Alday-Parejo, Kedar Ghimire, Oriana Coquoz, Gioele W. Albisetti, Luca Tamò, Jelena Zaric, Jimmy Stalin, Curzio Rüegg
ABSTRACT MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, β3-integrin, talin 1, tensin 3 and α-4-actinin at mature focal adhesions and actin stress fibers, and regulates their dynamics. Downregulation of MAGI1 reduces focal adhesion formation and
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A role for GLUT3 in glioblastoma cell invasion that is not recapitulated by GLUT1 Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-04-12 Catherine J Libby, Sajina Gc, Gloria A. Benavides, Jennifer L. Fisher, Sarah E. Williford, Sixue Zhang, Anh Nhat Tran, Emily R. Gordon, Amber B. Jones, Kaysaw Tuy, William Flavahan, Juan Gordillo, Ashlee Long, Sara J. Cooper, Brittany N. Lasseigne, Corinne E. Augelli-Szafran, Victor Darley-Usmar, Anita B. Hjelmeland
ABSTRACT The multifaceted roles of metabolism in invasion have been investigated across many cancers. The brain tumor glioblastoma (GBM) is a highly invasive and metabolically plastic tumor with an inevitable recurrence. The neuronal glucose transporter 3 (GLUT3) was previously reported to correlate with poor glioma patient survival and be upregulated in GBM cells to promote therapeutic resistance
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Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-04-12 Si-yu Sun, Yu-mei Cao, Yan-jie Huo, Fei Qiu, Wen-juan Quan, Chao-ping He, Yu Chen, Duan-fang Liao, Qin-hui Tuo
ABSTRACT Phenotypic switching is the main cause of the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). We previously showed that Daxx exerted negative regulatory effect on AngII-induced VSMC proliferation and migration. However, the function of Daxx in VSMC phenotype switching remained unknown. Nicotinate-curcumin (NC) is an esterification derivative of niacin and curcumin
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Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-03-18 Yanling Jin, Wei Liu, Fengxia Wang, Min Wang, Kai Xu, Aijun Yang, Chenyu Wang, Lihan Zhang, Fangfang Zhang, Min Li
ABSTRACT Tissue factor (TF) has been extensively studied for tumor metastasis, but its role in mediating cancer cell adhesion to vasculature remains unknown. This study aimed to measure the ability of TF to mediate the adhesion of breast cancer cells to human umbilical vein endothelial cells (HUVECs). MDA-MB-231 cells expressed the highest TF level and adhered more to HUVECs under static and flow conditions
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The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-03-16 Andrea A. Villanueva, Pilar Sanchez-Gomez, Ernesto Muñoz-Palma, Sofía Puvogel, Bárbara S. Casas, Cecilia Arriagada, Isaac Peña-Villalobos, Pablo Lois, Manuel Ramírez Orellana, Fabiana Lubieniecki, Fernando Casco Claro, Iván Gallegos, Javier García-Castro, Vicente A. Torres, Verónica Palma
ABSTRACT Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma. Here, we show that Netrin-1 ligand binding to Neogenin-1 leads to FAK autophosphorylation and integrin β1 activation in a FAK dependent manner, thus promoting neuroblastoma
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α– Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-03-16 Smita Eknath Desale, Subashchandrabose Chinnathambi
ABSTRACT Microglia, the resident immune cells, were found to be activated to inflammatory phenotype in Alzheimer’s disease (AD). The extracellular burden of amyloid-β plaques and Tau seed fabricate the activation of microglia. The seeding effect of extracellular Tau species is an emerging aspect to study about Tauopathies in AD. Tau seeds enhance the propagation of disease along with its contribution
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Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-02-11 Wishrawana S. Ratnayake, Christopher A. Apostolatos, Sloan Breedy, Clare L. Dennison, Robert Hill, Mildred Acevedo-Duncan
ABSTRACT Atypical protein kinase C (aPKC) are involved in progression of many human cancers. Vimentin is expressed during epithelial to mesenchymal transition (EMT). Molecular dynamics of Vimentin intermediate filaments (VIFs) play a key role in metastasis. This article is an effort to provide thorough understanding of the relationship between Vimentin and aPKCs . We demonstrate that diminution of
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Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-02-01 Wishrawana S. Ratnayake, Christopher A. Apostolatos, Sloan Breedy, Clare L. Dennison, Robert Hill, Mildred Acevedo-Duncan
Abstract Atypical protein kinase C (aPKC) are involved in cellular survival, differentiation, and metastasis of many human cancers. Epithelial to mesenchymal transition (EMT) is an important process in tumor progression that converts stationary epithelial cells into motile mesenchymal cells by expressing Vimentin. Molecular dynamics of Vimentin intermediate filaments (VIFs) depend on phosphorylation
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Group I p21-activated kinases in leukemia cell adhesion to fibronectin. Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-12-01 Kateřina Kuželová,Adam Obr,Pavla Röselová,Dana Grebeňová,Petra Otevřelová,Barbora Brodská,Aleš Holoubek
P21-activated kinases (PAK) regulate processes associated with cytoskeleton dynamics. PAK expression in leukemia cells was measured on protein and mRNA levels. In functional assays, we analyzed the effect of PAK inhibitors IPA-3 and FRAX597 on cell adhesivity and viability. PAK2 was dominant in cell lines, whereas primary cells also expressed comparable amount of PAK1 transcription isoforms: PAK1-full
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Group I p21-activated kinases in leukemia cell adhesion to fibronectin Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-01-19 Kateřina Kuželová, Adam Obr, Pavla Röselová, Dana Grebeňová, Petra Otevřelová, Barbora Brodská, Aleš Holoubek
ABSTRACT P21-activated kinases (PAK) regulate processes associated with cytoskeleton dynamics. PAK expression in leukemia cells was measured on protein and mRNA levels. In functional assays, we analyzed the effect of PAK inhibitors IPA-3 and FRAX597 on cell adhesivity and viability. PAK2 was dominant in cell lines, whereas primary cells also expressed comparable amount of PAK1 transcription isoforms:
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Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells Cell Adhes. Migr. (IF 3.2) Pub Date : 2021-01-04 Sarah Alsharif, Pooja Sharma, Karina Bursch, Rachel Milliken, Van Lam, Arwa Fallatah, Thuc Phan, Meagan Collins, Priya Dohlman, Sarah Tiufekchiev, Georges Nehmetallah, Christopher B. Raub, Byung Min Chung
ABSTRACT A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated,we found that K19 is required to maintain rounded epithelial-like shape and tight cell-cell adhesion. A loss of K19 also lowered cell surface E-cadherin levels. Inhibiting internalization restored cell-cell adhesion
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MicroRNA-203 inhibits epithelial-mesenchymal transition, migration, and invasion of renal cell carcinoma cells via the inactivation of the PI3K/AKT signaling pathway by inhibiting CAV1 Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-11-22 Ning Han, Hai Li, Hui Wang
ABSTRACT The present study aimed to evaluate the underlying mechanism of microRNA-203 (miR-203) in renal cell carcinoma (RCC) involving the PI3K/AKT signaling pathway. The results revealed downregulated miR-203 and upregulated CAV1 in RCC tissues. Upregulated miR-203 and downregulated CAV1 increased E-cadherin expression and cell apoptosis, decreased β-catenin and N-cadherin expression and cell proliferation
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Short-term ex-vivo exposure to hydrogen sulfide enhances murine hematopoietic stem and progenitor cell migration, homing, and proliferation Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-11-11 Anoushka Khanna, Namita Indracanti, Rina Chakrabarti, Prem Kumar Indraganti
ABSTRACT For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mononuclear cells (BMMNCs) to Sodium Hydrogen Sulfide (NaHS, hydrogen sulfide-H2S
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The focal adhesion protein Integrin-Linked Kinase (ILK) as an important player in breast cancer pathogenesis Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-10-12 Katerina Tsirtsaki, Vasiliki Gkretsi
ABSTRACT Cell-extracellular matrix interactions, or focal adhesions (FA), are crucial for tissue homeostasis but are also implicated in cancer. Integrin-Linked Kinase (ILK) is an abundantly expressed FA protein involved in multiple signaling pathways. Here, we reviewed the current literature on the role of ILK in breast cancer (BC). Articles included in vitro and in vivo experiments as well as studies
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KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-10-07 Lan Sun,Xiaona Zhou,Yanmeng Li,Wei Chen,Shanna Wu,Bei Zhang,Jingyi Yao,Anjian Xu
ABSTRACT Krüppel-like factor 5 (KLF5) can both promote and suppress cell migration, but the underlying mechanisms have not been elucidated. In this study, we show that the function of KLF5 in epithelial-mesenchymal transition (EMT) and migration of liver cancer cells depends on the status of the cellular tumor antigen p53 (p53). Furthermore, zinc finger E-box-binding homeobox 2 (ZEB2) is the main regulator
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SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-10-04 Yusuke Mizutani, Daisuke Omagari, Manabu Hayatsu, Masaaki Nameta, Kazuo Komiyama, Yoshikazu Mikami, Tatsuo Ushiki
ABSTRACT To elucidate the underlying mechanism of secretory leukocyte protease inhibitor (SLPI)-induced cell migration, we compared SLPI-deleted human gingival carcinoma Ca9-22 (ΔSLPI) cells and original (wild-type: wt) Ca9-22 cells using several microscopic imaging methods and gene expression analysis. Our results indicated reduced migration of ΔSLPI cells compared to wtCa9-22 cells. The lamellipodia/dorsal
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Structure, regulatory factors and cancer-related physiological effects of ADAM9. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-09-12 M A Haoyuan,L I Yanshu
The ADAMs family belongs to the transmembrane protein superfamily of zinc-dependent metalloproteases, which consists of multiple domains. These domains have independent but complementary functions that enable them to participate in multiple biological processes. Among them, ADAM9 can not only participate in the degradation of extracellular matrix as a metalloprotease, but also mediate tumor cell adhesion
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Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-12-01 Zhao Wang,Zhiqi Wang,Yusheng Pang,Huili Tong,Yunqin Yan,Shuang Li,Shufeng Li
FNDC4 is an anti-inflammatory factor that alters the activation state of macrophages; it is used to treat colitis in mice. However, its role in muscle formation and mechanism of function remains unknown. We found that FNDC4 promotes the bovine MDSCs migration and differentiation. Furthermore, we reported that it interacts with integrin β1 (ITGβ1). FAK, mediated by ITGβ1, regulates cell migration. Our
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Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-09-03 Zhao Wang, Zhiqi Wang, Yusheng Pang, Huili Tong, Yunqin Yan, Shuang Li, Shufeng Li
FNDC4 is an anti-inflammatory factor that alters the activation state of macrophages; it is used to treat colitis in mice. However, its role in muscle formation and mechanism of function remains unknown. We found that FNDC4 promotes the bovine MDSCs migration and differentiation. Furthermore, we reported that it interacts with integrin β1 (ITGβ1). FAK, mediated by ITGβ1, regulates cell migration. Our
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The functions of kinesin and kinesin-related proteins in eukaryotes. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-08-25 Iftikhar Ali,Wei-Cai Yang
Kinesins constitute a superfamily of ATP-driven microtubule motor enzymes that convert the chemical energy of ATP hydrolysis into mechanical work along microtubule tracks. Kinesins are found in all eukaryotic organisms and are essential to all eukaryotic cells, involved in diverse cellular functions such as microtubule dynamics and morphogenesis, chromosome segregation, spindle formation and elongation
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The anti-cancer properties of heparin and its derivatives: a review and prospect. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-06-14 Sai-Nan Ma,Zhi-Xiang Mao,Yang Wu,Ming-Xing Liang,Dan-Dan Wang,Xiu Chen,Ping-An Chang,Wei Zhang,Jin-Hai Tang
ABSTRACT Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival. Heparin can affect the proliferation, adhesion, angiogenesis, migration and invasion of cancer cells via multiple mechanisms. The main mechanisms involve inhibition of heparanase
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Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-05-19 Joanna Pastwińska,Aurelia Walczak-Drzewiecka,Magdalena Łukasiak,Marcin Ratajewski,Jarosław Dastych
ABSTRACT A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors. We investigated the effect of hypoxia on integrin-mediated mast cell adhesion to fibronectin. We found that it was mediated by the α5/β1 receptor and that hypoxia significantly upregulated
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Golgi α1,2-mannosidase I induces clustering and compartmentalization of CD147 during epithelial cell migration. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-05-18 Miguel Gonzalez-Andrades,Supriya S Jalimarada,Maria Rodriguez-Benavente,Marissa N Feeley,Ashley M Woodward,Dina B AbuSamra,Pablo Argüeso
ABSTRACT CD147 is a widely expressed matrix metalloproteinase inducer involved in the regulation of cell migration. The high glycosylation and ability to undergo oligomerization have been linked to CD147 function, yet there is limited understanding on the molecular mechanisms behind these processes. The current study demonstrates that the expression of Golgi α1,2-mannosidase I is key to maintaining
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FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-05-18 Ying Yang,Tingting Lu,Ziming Li,Shun Lu
ABSTRACT Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC. Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blot. Cell migration and invasion were assessed by transwell assay. Key findings: CCND1 was co-overexpressed with
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Inhibition of DDR1 reduces invasive features of human A375 melanoma, HT29 colon carcinoma and SK-HEP hepatoma cells. Cell Adhes. Migr. (IF 3.2) Pub Date : 2020-03-03 Irene Romayor,Iker Badiola,Elvira Olaso
ABSTRACT DDR1 is a receptor tyrosine kinases for collagen and an adverse prognostic factor in primary and metastatic tumors.Despite this, DDR1 signaling and its functional consequences in tumor development remain unclear. RT-PCR and Western blot show that A375, colon carcinoma HT29 and liver carcinoma SK-HEP human cell lines express functional DDR1 that phosphorylates in response to collagen type I