-
FUT4 promotes the progression of Cholangiocarcinoma by modulating epithelial-mesenchymal transition Cell cycle (IF 4.3) Pub Date : 2024-03-11 Enchi Liu, Xingwang Qian, Yuan He, Kunlun Chen
Cholangiocarcinoma (CCA) is a common gastrointestinal malignancy characterized by a poor prognosis. Considering its prevalence, exploring its underlying molecular biological mechanisms is of paramo...
-
Sustained activation of NF-κB through constitutively active IKKβ leads to senescence bypass in murine dermal fibroblasts Cell cycle (IF 4.3) Pub Date : 2024-03-10 Masayuki Harada, Kanae Su-Harada, Takeshi Kimura, Koh Ono, Noboru Ashida
Although the transcription factor nuclear factor κB (NF-κB) plays a central role in the regulation of senescence-associated secretory phenotype (SASP) acquisition, our understanding of the involvem...
-
Gene expression profile of mitogen-activated kinases and microRNAs controlling their expression in HaCaT cell culture treated with lipopolysaccharide A and cyclosporine A Cell cycle (IF 4.3) Pub Date : 2024-03-06 Michał Wójcik, Nikola Zmarzły, Alicja Derkacz, Tomasz Kulpok-Bagiński, Natasza Blek, Beniamin Oskar Grabarek
Studies indicate that mitogen-activated protein kinases (MAPKs) are activated and overexpressed in psoriatic lesions. The aim of the study was to assess changes in the expression pattern of genes e...
-
Extracellular vesicles from Fusobacterium nucleatum: roles in the malignant phenotypes of gastric cancer Cell cycle (IF 4.3) Pub Date : 2024-03-06 Xiangkun Meng, Gang Ma, Xu Zhang, Hua Yin, Yu Miao, Fang He
The increase of the Fusobacterium nucleatum level has been previously identified in various cancers including gastric cancer (GC), but how the F. nucleatum exerts its carcinogenic role in GC remain...
-
The sorafenib resistance-related gene signature predicts prognosis and indicates immune activity in hepatocellular carcinoma Cell cycle (IF 4.3) Pub Date : 2024-03-05 Tianxin Luo, Xiaomei Chen, Wei Pan, Shu Zhang, Jian Huang
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. Most patients with advanced HCC acquire sorafenib resistance. Drug resistance reflects the heteroge...
-
Sirt6 promotes DNA damage repair in osteoarthritis chondrocytes by activating the Keap1/Nrf2/HO-1 signaling pathway Cell cycle (IF 4.3) Pub Date : 2024-02-22 Ling-Wei Mao, Qin-Yi Jiang, Nan Meng, Li Xiao, Qi Zhang, Yong-Xin Chen, Lin-Juan Liu, Lei Wang
The aim of this study was to explore the effect and mechanism of Sirt6 on DNA damage repair in OA chondrocytes. Cartilage tissues were collected from OA patients with knee arthroplasty and traumati...
-
ARRDC3 regulates the targeted therapy sensitivity of clear cell renal cell carcinoma by promoting AXL degradation Cell cycle (IF 4.3) Pub Date : 2024-02-22 Mulin Chen, Bingde Yin, Yao Liu, Mingzi Li, Suqin Shen, Jiaxue Wu, Weiguo Li, Jie Fan
AXL plays crucial roles in the tumorigenesis, progression, and drug resistance of neoplasms; however, the mechanisms associated with AXL overexpression in tumors remain largely unknown. In this stu...
-
ZC3H12A inhibits tumor growth and metastasis of breast cancer under hypoxic condition via the inactivation of IL-17 signaling pathway Cell cycle (IF 4.3) Pub Date : 2024-02-15 Zhongbing Luo, Fulan Yang, Kang Liu, Zhenluo Ding
Hypoxia is a major contributor to tumor microenvironment (TME) and metastasis in most solid tumors. We seek to screen hypoxia-related genes affecting metastasis in breast cancer and to reveal relat...
-
TOP3A coupling with replication forks and repair of TOP3A cleavage complexes Cell cycle (IF 4.3) Pub Date : 2024-02-11 Liton Kumar Saha, Yves Pommier
Humans have two Type IA topoisomerases, topoisomerase IIIα (TOP3A) and topoisomerase IIIβ (TOP3B). In this review, we focus on the role of human TOP3A in DNA replication and highlight the recent pr...
-
Small extracellular vesicles promote the formation of the pre-metastatic niche through multiple mechanisms in colorectal cancer Cell cycle (IF 4.3) Pub Date : 2024-02-11 Jiyang Wu, Xiaoxing Wang, Zhengzhe Li, Xiaomei Yi, Die Hu, Qi Wang, Tianyu Zhong
Colorectal cancer (CRC) ranks among the most prevalent global malignancies, posing significant threats to human life and health due to its high recurrence and metastatic potential. Small extracellu...
-
B-cell ALL with SOX11 gene amplification associates with a worse outcome Cell cycle (IF 4.3) Pub Date : 2024-02-13 George Angelakakis, Mallika Varkhedi, Toriana R. Dabkowski, Michael J. Diaz, Michelle Yeagley, George Blanck
Copy number variation (CNV) of certain genes in pediatric Acute Lymphoblastic Leukemia (ALL) impacts gene expression levels. Here, we aimed to investigate the potential prognostic utility of CNVs i...
-
-
Entero-toxigenic Bacteroides fragilis contributes to intestinal barrier injury and colorectal cancer progression by mediating the BFT/STAT3/ZEB2 pathway Cell cycle (IF 4.3) Pub Date : 2024-01-25 Jian Yang, Xue Wang, Tao Hu, He Huang, Gang Chen, Bo Jin, Guilin Zeng, Jian Liu
Our previous findings confirmed the high enrichment of Bacteroides fragilis (BF) in fecal samples from patients with colorectal cancer (CRC). The intestinal mucosal barrier is the first defense of ...
-
MiR-548t-5p regulates pancreatic ductal adenocarcinoma metastasis through an IL-33-dependent crosstalk between cancer cells and M2 macrophages Cell cycle (IF 4.3) Pub Date : 2024-01-24 Yan Wang, Wan-Li Ge, Shao-Jun Wang, Yu-Yong Liu, Zhi-Han Zhang, Yang Hua, Xiong-Fei Zhang, Jing-Jing Zhang
IL-33 has been associated with pro- and anticancer functions in cancer. However, its role in pancreatic cancer metastasis remains unknown. This study aimed to explore the role of miR-548t-5p/IL-33 ...
-
YAP1 expression in colorectal cancer confers the aggressive phenotypes via its target genes Cell cycle (IF 4.3) Pub Date : 2024-01-23 Haoyuan Chen, Yangyang Shang, Xia Li, Rongquan Wang
Yes-associated protein1 (YAP1), a downstream effector of the Hippo pathway, is over-expressed in several types of malignancies. We analyzed retrospectively the TCGA database using 447 colorectal ca...
-
Impact of sunitinib resistance on clear cell renal cell carcinoma therapeutic sensitivity in vitro Cell cycle (IF 4.3) Pub Date : 2024-01-23 Susmita Ghosh, Mamatha Garige, Patrick R. Haggerty, Alexis Norris, Chao-Kai Chou, Wells W. Wu, Rong-Fong Shen, Carole Sourbier
Sunitinib resistance creates a major clinical challenge for the treatment of advanced clear cell renal cell carcinoma (ccRCC) and functional and metabolic changes linked to sunitinib resistance are...
-
Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes Cell cycle (IF 4.3) Pub Date : 2024-01-22 Hengjing He, Muhammad Jamal, Xingruo Zeng, Yufei Lei, Di Xiao, Zimeng Wei, Chengjie Zhang, Xiaoyu Zhang, Shan Pan, Qianshan Ding, Haiyan Tan, Songping Xie, Qiuping Zhang
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The oncogenic role of Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknow...
-
Integrated analysis of FHIT gene alterations in cancer Cell cycle (IF 4.3) Pub Date : 2024-01-18 Lucía Simón-Carrasco, Elena Pietrini, Andrés J. López-Contreras
The Fragile Histidine Triad Diadenosine Triphosphatase (FHIT) gene is located in the Common Fragile Site FRA3B and encodes an enzyme that hydrolyzes the dinucleotide Ap3A. Although FHIT loss is one...
-
Dehydroandrographolide alleviates rheumatoid arthritis by inhibiting neutrophil activation via LMIR3 in collagen induced arthritis rats Cell cycle (IF 4.3) Pub Date : 2024-01-17 Ning Kong, Huanshuai Guan, Xudong Duan, Ruomu Cao, Heng Li, Fangze Xing, Xueshan Du, Yi Zheng, Lei Zhang, Yiyang Li, Zeyu Liu, Run Tian, Kunzheng Wang, Delu Che, Pei Yang
Rheumatoid arthritis (RA) is an inflammatory disease which causes severe pain and disability. Neutrophils play essential roles in the onset and progression of RA; thus, inhibition of neutrophil act...
-
Transforming growth factor-β and bone morphogenetic protein signaling pathways in pathological cardiac hypertrophy Cell cycle (IF 4.3) Pub Date : 2024-01-18 Jing Wen, Guixiang Liu, Mingjie Liu, Huarui Wang, Yunyan Wan, Zhouhong Yao, Nannan Gao, Yuanyuan Sun, Ling Zhu
Pathological cardiac hypertrophy (referred to as cardiac hypertrophy) is a maladaptive response of the heart to a variety of pathological stimuli, and cardiac hypertrophy is an independent risk fac...
-
Identification of novel potential homologous repair deficiency-associated genes in pancreatic adenocarcinoma via WGCNA coexpression network analysis and machine learning Cell cycle (IF 4.3) Pub Date : 2024-01-18 Chun Liu, Jingyun Fang, Weibiao Kang, Yang Yang, Changjun Yu, Hao Chen, Yongwei Zhang, Huan Ouyang
Homologous repair deficiency (HRD) impedes double-strand break repair, which is a common driver of carcinogenesis. Positive HRD status can be used as theranostic markers of response to platinum- an...
-
SIRT1 alleviates insulin resistance and respiratory distress in late preterm rats by activating QKI5-mediated PPARγ/PI3K/AKT pathway Cell cycle (IF 4.3) Pub Date : 2024-01-18 Jinxiao He, Fang Fan, Jingxian Li, Yi Han, Ye Song, Rong Zhang, Yang Xu, Huajie Wu, Rui Fan
Neonatal respiratory distress syndrome (NRDS) is a common complication of gestational diabetes mellitus (GDM) and late preterm births. Research suggests that SIRT1 was involved in LPS-induced acute...
-
SMAD7 gene polymorphisms and their influence on patients with colorectal cancer Cell cycle (IF 4.3) Pub Date : 2024-01-18 Yongsheng Wu, Jue Xu, Biaobin Tan, Ting Yi, Su Liu, Guang Yang, Kai Li, Xinhan Zhao
Colorectal cancer (CRC) is a prevalent malignant tumor, and its pathogenesis is still not fully understood. Studies have shown that SMAD7 gene polymorphisms can affect CRC susceptibility, but the r...
-
CXADR promote epithelial–mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling Cell cycle (IF 4.3) Pub Date : 2024-01-18 Hang-Jing Tan, Zi-Heng Deng, Chun Zhang, Hong-Wen Deng, Hong-Mei Xiao
Endometriosis is a benign high prevalent disease exhibiting malignant features. However, the underlying pathogenesis and key molecules of endometriosis remain unclear. By integrating and analysis o...
-
PSMC2 knockdown exerts an anti-tumor role in nasopharyngeal carcinoma through regulating AKT signaling pathway Cell cycle (IF 4.3) Pub Date : 2024-01-18 Jin Su, Shousen Hu, Shiping Ding, Kun Feng
Nasopharyngeal carcinoma is a major public health problem in several countries, particularly in Southeast Asia and North Africa. However, the mechanism underlying the malignant biological behaviors...
-
High-density lipoprotein protects vascular endothelial cells from indoxyl sulfate insults through its antioxidant ability Cell cycle (IF 4.3) Pub Date : 2024-01-18 Ching Chen, Chia-Chi Chang, I-Ta Lee, Chun-Yao Huang, Feng-Yen Lin, Shing-Jong Lin, Jaw-Wen Chen, Ting-Ting Chang
Chronic kidney disease (CKD) patients have a high risk of cardiovascular disease. Indoxyl sulfate (IS) is a uremic toxin that has been shown to inhibit nitric oxide production and cause cell senesc...
-
Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis Cell cycle (IF 4.3) Pub Date : 2024-01-18 Xianwei Huang, Xiong Liu, Jiyan Lin
Obesity poses significant health risks and can negatively impact an individual’s quality of life. The human obesity phenotype results from the differentiation of pre-adipocytes into adipocytes, whi...
-
The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions Cell cycle (IF 4.3) Pub Date : 2024-01-18 Nian-Siou Wu, I-Chu Ma, Yi-Fan Lin, Huey-Jiun Ko, Joon-Khim Loh, Yi-Ren Hong
Recent study had deepened our knowledge of the mitochondrial dynamics to classify mitochondrial fission into two types. To further clarify the relationship between the two distinct fission machiner...
-
m6A-mediated lncRNA MAPKAPK5-AS1 induces apoptosis and suppresses inflammation via regulating miR-146a-3p/SIRT1/NF-κB axis in rheumatoid arthritis Cell cycle (IF 4.3) Pub Date : 2024-01-16 Jianting Wen, Jian Liu, Lei Wan, Hui Jiang, Ling Xin, Yue Sun, Yanyan Fang, Xin Wang, Jie Wang
To investigate the role of m6A-mediated lncRNA MAPKAPK5-AS1 (MK5-AS1) in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and its underlying molecular mechanism. RT-qPCR, western blot, f...
-
Telomere dynamics in human pluripotent stem cells Cell cycle (IF 4.3) Pub Date : 2024-01-14 Buyun Ma, Paula Martínez, Raúl Sánchez-Vázquez, Maria A. Blasco
Pluripotent stem cells (PSCs) are a promising source of stem cells for regenerative therapies. Stem cell function depends on telomere maintenance mechanisms that provide them with the proliferative...
-
TACC3: a multi-functional protein promoting cancer cell survival and aggressiveness Cell cycle (IF 4.3) Pub Date : 2024-01-10 Ozge Saatci, Ozgur Sahin
TACC3 is the most oncogenic member of the transforming acidic coiled-coil domain-containing protein (TACC) family. It is one of the major recruitment factors of distinct multi-protein complexes. TA...
-
Translocated HMGB3 is involved in papillary thyroid cancer progression by activating cytoplasmic TLR3 and transmembrane TREM1 Cell cycle (IF 4.3) Pub Date : 2024-01-10 Yang Zhao, Hong-Jun Lv, Xue-Yang Deng, Pu Chen, Malgorzata A. Garstka, Bing-Yin Shi, Jiao Fu
The family of high mobility group box (HMGB) proteins participates in various biological processes including immunity, inflammation, as well as cancer formation and progression. However, its role i...
-
The role of lncRNA SNHG14 in gastric cancer: enhancing tumor cell proliferation and migration, and mechanisms of CDH2 expression Cell cycle (IF 4.3) Pub Date : 2024-01-09 Zhou-Tong Dai, Yong-Lin Wu, Tao Xu, Xing-Rui Li, Teng Ji
LncRNAs are a class of non-coding RNAs that play an important role in regulating gene expression. However, their specific molecular mechanisms in gastric carcinogenesis and metastasis need further ...
-
The role of CSTF2 in cancer: from technology to clinical application Cell cycle (IF 4.3) Pub Date : 2024-01-02 Jiaxiang Ding, Yue Su, Youru Liu, Yuanyuan Xu, Dashuai Yang, Xuefeng Wang, Shuli Hao, Huan Zhou, Hongtao Li
A protein called cleavage-stimulating factor subunit 2 (CSTF2, additionally called CSTF-64) binds RNA and is needed for the cleavage and polyadenylation of mRNA. CSTF2 is an important component sub...
-
Identification of molecular subtypes and prognostic model to reveal immune infiltration and predict prognosis based on immunogenic cell death-related genes in lung adenocarcinoma Cell cycle (IF 4.3) Pub Date : 2024-01-02 Yinying Dong, Xiao Yu, Hao Song, Qingfeng Chen, Bin Zheng, Xiaomeng Ji, Mingjin Xu, Jian Liu, Xiangyin Sun, Qiuxiao Wang, Ruimei Ren, Haijun Lu
Immunogenic cell death (ICD) has been increasingly indicated to be related to caners. However, ICD’s role in Lung adenocarcinoma (LUAD) is still not well investigated. Clinical data along with asso...
-
Drug-induced inhibition of HMGA and EZH2 activity as a possible therapy for anaplastic thyroid carcinoma Cell cycle (IF 4.3) Pub Date : 2024-01-02 Marco De Martino, Simona Pellecchia, Myriam Decaussin-Petrucci, Domenico Testa, Nathalia Meireles Da Costa, Pierlorenzo Pallante, Paolo Chieffi, Alfredo Fusco, Francesco Esposito
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal neoplasms in humans, and just limited progresses have been made to extend patient survival and decrease ATC-associated mo...
-
LncRNA ABHD11-AS1 activates EGFR signaling to promote cervical cancer progression by preventing FUS-mediated degradation of ABHD11 mRNA Cell cycle (IF 4.3) Pub Date : 2023-12-26 Ting Yang, Sijuan Tian, Juan Zhao, Meili Pei, Minyi Zhao, Xiaofeng Yang
Cervical cancer is one of the most common gynecological cancers with high metastasis, poor prognosis and conventional chemotherapy. The long non-coding RNA (lncRNA) ABHD11 antisense RNA 1 (ABHD11-A...
-
Knockdown of HNRNPM inhibits the progression of glioma through inducing ferroptosis Cell cycle (IF 4.3) Pub Date : 2023-12-15 Jian Wang, Xiaolin Luo, Dehua Liu
Ferroptosis acts as an important regulator in diverse human tumors, including the glioma. This study aimed to screen potential ferroptosis-related genes involved in the progression of glioma.Differ...
-
Structural and functional insights into GSDMB isoforms complex roles in pathogenesis Cell cycle (IF 4.3) Pub Date : 2023-12-15 Sara Colomo, David Ros-Pardo, Sara S Oltra, Paulino Gomez-Puertas, David Sarrio, Gema Moreno-Bueno
Gasdermins (GSDMs) have garnered significant scientific interest due to their protective and detrimental roles in innate immunity, host defense, inflammation, and cancer alongside with other pathol...
-
Understanding cellular senescence: pathways involved, therapeutics and longevity aiding Cell cycle (IF 4.3) Pub Date : 2023-12-15 Ashish Kumar, Kavitha Thirumurugan
A normal somatic cell undergoes cycles of finite cellular divisions. The presence of surveillance checkpoints arrests cell division in response to stress inducers: oxidative stress from excess free...
-
Role of non-coding RNAs as new therapeutic targets in regulating the EMT and apoptosis in metastatic gastric and colorectal cancers Cell cycle (IF 4.3) Pub Date : 2023-12-15 Nasim Ebrahimi, Ali Hakimzadeh, Farima Bozorgmand, Sepehr Speed, Mahdokht Sadat Manavi, Roya Khorram, Kobra Farahani, Fatemeh Rezaei-Tazangi, Atena Mansouri, Michael R Hamblin, Amir Reza Aref
Colorectal cancer (CRC) and gastric cancer (GC), are the two most common cancers of the gastrointestinal tract, and are serious health concerns worldwide. The discovery of more effective biomarkers...
-
ACLY promotes gastric tumorigenesis and accelerates peritoneal metastasis of gastric cancer regulated by HIF-1A Cell cycle (IF 4.3) Pub Date : 2023-12-15 Zhengyuan Yan, Kanghui Liu, Peng Xu, Zhengwei Chen, Pengpeng Zhang, Shengbin Pei, Quan Cheng, Shansong Huang, Bowen Li, Jialun Lv, Zekuan Xu, Hao Xu, Li Yang, Diancai Zhang
Mounting evidence indicates the potential involvement of ATP-citrate lyase (ACLY) in the modulation of various cancer types. Nevertheless, the precise biological significance of ACLY in gastric can...
-
Association of LOX gene G473A polymorphism with the occurrence of allergic rhinitis and efficacy of montelukast sodium in children Cell cycle (IF 4.3) Pub Date : 2023-12-15 Xikun Yao, Yan Liu, Hong Jiao, Wenjie Ma, Minliang Chen
Allergic rhinitis (AR) is very common in adolescents, and current treatment options are complex and unsatisfactory. The objective of this study was to analyze the association of lysyl oxidase (LOX)...
-
IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification Cell cycle (IF 4.3) Pub Date : 2023-12-15 Tao Wu, Li Liao, Tao Wu, Shuai Chen, Qilin Yi, Min Xu
A growing number of studies have shown the prognostic importance of Cell division cycle protein 45 (CDC45) in hepatocellular carcinoma (HCC). This study aims to investigate the biological function ...
-
Multi-omics integration analysis unveils heterogeneity in breast cancer at the individual level Cell cycle (IF 4.3) Pub Date : 2023-12-15 Zhangxiang Zhao, Tongzhu Jin, Bo Chen, Qi Dong, Mingyue Liu, Jiayu Guo, Xiaoying Song, Yawei Li, Tingting Chen, Huiming Han, Haihai Liang, Yunyan Gu
Identifying robust breast cancer subtypes will help to reveal the cancer heterogeneity. However, previous breast cancer subtypes were based on population-level quantitative gene expression, which i...
-
Exosome-delivered circRNA circSYT15 contributes to cisplatin resistance in cervical cancer cells through the miR-503-5p/RSF1 axis Cell cycle (IF 4.3) Pub Date : 2023-12-15 Zhilong Chen, Zhen Xu, Qian Wang, Lu Wang, Hailing Zhang, Wuliang Wang, Hu Zhao, Yilin Guo, Jinquan Cui
The development of chemotherapy resistance is a major obstacle for cervical cancer (CC) patients. Exosome-mediated transfer of circular RNAs (circRNAs) was found to have relevance to the CC. This s...
-
Depleting ANTXR1 suppresses glioma growth via deactivating PI3K/AKT pathway Cell cycle (IF 4.3) Pub Date : 2023-12-05 Chaoyang Zhou, Aijun Liang, Jianzhong Zhang, Jingxing Leng, Bin Xi, Bin Zhou, Yu Yang, Ronglan Zhu, Liangchen Zhong, Xingxing Jiang, Dengfeng Wan
Gliomas are commonly known as primary brain tumors and associated with frequent recurrence and an unsatisfactory prognosis despite extensive research in the underlying molecular mechanisms. We aime...
-
Role and mechanism of ferroptosis in acute lung injury Cell cycle (IF 4.3) Pub Date : 2023-12-05 Tingting Yu, Shibo Sun
Ferroptosis is a new non-apoptotic cell death caused by the accumulation of dysregulated metabolism of ferric iron, amino acids or lipid peroxidation. Increasing studies suggest that ferroptosis is...
-
SNHG15 promotes gallbladder cancer progression by enhancing the autophagy of tumor cell under nutrition stress Cell cycle (IF 4.3) Pub Date : 2023-12-05 He Min, Linhua Yang, Xinsen Xu, Yajun Geng, Fatao Liu, Yingbin Liu
Gallbladder cancer (GBC) is a major malignant carcinoma of the biliary tract with extremely poor prognosis. Currently, there is no useful therapy strategies for GBC treatment, indicating the unmet ...
-
Krüppel-like factor 5 activates chick intestinal stem cell and promotes mucosal repair after impairment Cell cycle (IF 4.3) Pub Date : 2023-12-05 Lingzi Yu, Sichao Qi, Guozhen Wei, Xi Rao, Danni Luo, Minyao Zou, Yuling Mi, Caiqiao Zhang, Jian Li
The mucosal renewal, which depends on the intestinal stem cell (ISC) activity, is the foundation of mucosal repairment. Importantly, activation of reserve ISCs (rISCs) plays a vital role in initiat...
-
Investigating the role of LncRNA PSMG3-AS1 in gastric cancer: implications for prognosis and therapeutic intervention Cell cycle (IF 4.3) Pub Date : 2023-12-05 Yi Wang, Zhongshi Hong, Shenghong Wei, Zaisheng Ye, Luchuan Chen, Chengzhi Qiu
LncRNAs are widely linked to the complex development of gastric cancer, which is acknowledged worldwide as the third highest contributor to cancer-related deaths and the fifth most common form of c...
-
Targeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer Cell cycle (IF 4.3) Pub Date : 2023-12-05 MC. Rowell, X. Deschênes-Simard, S. Lopes-Paciencia, B. Le Calvé, P. Kalegari, L. Mignacca, A. Fernandez-Ruiz, J. Guillon, F. Lessard, V. Bourdeau, S Igelmann, AM. Duman, Y. Stanom, F. Kottakis, V. Deshpande, V. Krizhanovsky, N. Bardeesy, G. Ferbeyre
Pancreatic adenocarcinomas (PDAC) often possess mutations in K-Ras that stimulate the ERK pathway. Aberrantly high ERK activation triggers oncogene-induced senescence, which halts tumor progression...
-
Epididymal segment-specific miRNA and mRNA regulatory network at the single cell level Cell cycle (IF 4.3) Pub Date : 2023-12-05 Tong Chen, Liangyu Yao, Wen Liu, Jiaochen Luan, Yichun Wang, Chao Yang, Xiang Zhou, Chengjian Ji, Xuejiang Guo, Zengjun Wang, Ninghong Song
Spermatozoa released from the testis cannot fertilize an egg before becoming mature and motile in the epididymis. Based on three bulk and one single-cell RNA-seq (scRNA-seq) data series, we compare...
-
Lung adenocarcinoma presenting with intrapulmonary metastases through air spaces concomitant with silicosis: a case report and literature review Cell cycle (IF 4.3) Pub Date : 2023-12-05 Guzong Wang, Wenbin Hu, Binjun He, Yanhong Ma
Herein, we reported a rare case of bilateral intrapulmonary metastases spread through air spaces (STAS) and silicosis to advance understanding and knowledge of this disease. A middle-aged man was d...
-
3,5-diCQA suppresses colorectal cancer cell growth through ROS/AMPK/mTOR mediated mitochondrial dysfunction and ferroptosis Cell cycle (IF 4.3) Pub Date : 2023-11-23 Weibing Wang, Xingwei Xu, Long Zhao, Kailun Ye, Saisai Wang, Caizhao Lin
3,5-diCQA has been shown to have anti-tumor effect by decreasing cancer cell growth. However, the molecular mechanism by which 3,5-diCQA impacts colorectal cancer (CRC) cells is unknown. This study...
-
HGH1 and the immune landscape: a novel prognostic marker for immune-desert tumor microenvironment identification and immunotherapy outcome prediction in human cancers Cell cycle (IF 4.3) Pub Date : 2023-11-23 Gujie Wu, Yipeng Dong, Qin Hu, Huiyun Ma, Qun Xu, Kun Xu, Hongyu Chen, Zheng Yang, Min He
HGH1 homolog, a protein-coding gene, plays a crucial role in human growth and development. However, its role in human cancer remains unclear. For the first time, this study comprehensively evaluate...
-
Pan-cancer integrated bioinformatic analysis of RNA polymerase subunits reveal RNA Pol I member CD3EAP regulates cell growth by modulating autophagy Cell cycle (IF 4.3) Pub Date : 2023-11-23 Nikita Bhandari, Disha Acharya, Annesha Chatterjee, Lakshana Mandve, Pranjal Kumar, Shreesh Pratap, Pushkar Malakar, Sudhanshu K. Shukla
Transcription is a crucial stage in gene expression. An integrated study of 34 RNA polymerase subunits (RNAPS) in the six most frequent cancer types identified several genetic and epigenetic modifi...
-
Tumor-derived CircRNA_102191 promotes gastric cancer and facilitates M2 macrophage polarization Cell cycle (IF 4.3) Pub Date : 2023-11-23 Min Yao, Xuhua Mao, Zherui Zhang, Yue Xi, Haining Gan, Feilun Cui, Shihe Shao
Background: Gastric cancer is a common malignant tumor of the digestive tract and the fourth leading cause of death from cancer-related diseases. In recent years, many studies have found that circu...
-
RNF6 promotes gastric cancer progression by regulating CCNA1/CREBBP transcription Cell cycle (IF 4.3) Pub Date : 2023-11-23 Qiuyu Jiang, Jiyu Miao, Fei Wu, Fang Li, Jinyuan Zhang, Xintao Jing, Shuang Cai, Xiaoping Ma, Xiaofei Wang, Lingyu Zhao, Chen Huang
Ring finger protein 6 (RNF6) is a member of the E3 ubiquitin ligase family. Previous studies have reported the involvement of RNF6 as a ubiquitin ligase in the progression of gastric cancer (GC). H...
-
EIF4A3-regulated hsa_circ_0001445 can inhibit the progression of laryngeal squamous cell carcinoma via hsa-miR-432-5p-dependent up-regulation of RGMA expression Cell cycle (IF 4.3) Pub Date : 2023-11-23 Miaomiao Yu, Huan Cao, Jianwang Yang, Tao Liu, Jiaxue Gao, Baoshan Wang
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor in the head and neck, the 5-year relative survival rate of patients diagnosed with laryngeal cancer was estimated to be 61% from...