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Cytokine Profile Response of Human Peripheral Blood Mononuclear Cells Stimulated by Bartonella bacilliformis. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-11-15 Barbara Ymaña,Javier Enciso-Benavides,Gemma Moncunill,Maria J Pons
Carrion's disease is a neglected endemic disease found in remote Andean areas. As an overlooked disease, knowledge of innate immune responses to Bartonella bacilliformis, the etiological agent, is scarce. This study aimed to evaluate the cytokine response to B. bacilliformis using in vitro human peripheral blood mononuclear cells (PBMCs) stimulations. PBMCs from naive adults were isolated by gradient
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Impact of Chronic Moderate Exercise on Immune Cells and Cytokine Levels in Rats: Focus on the Endocannabinergic Pathway. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-11-14 Salvador Valencia-Sánchez,Karen Elizabeth Nava-Castro,Claudia Angélica Garay-Canales,Víctor Hugo Del Río-Araiza,Jorge Morales-Montor
Although the modulation of immunity by exercise has been a long-studied paradigm, the molecular pathways connecting the two are still not fully understood. Regular moderate aerobic exercise is associated with improved health and directly impacts the immune system by changing the proportion of cell subpopulations, their function, and interleukin production. The endocannabinoid system has gained importance
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Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-11-06 Yasaman Mortazavi,Robert Herrera,Matthieu Masureel,Timurs Maculins,Isabelle Lehoux,Jonathan Sockolosky,Nathan West,Beyza Bulutoglu,Yue Zhao
Interleukin 18 (IL-18) is a key cytokine involved in the activation of T and NK cells, which are major effector cells in tumor killing. However, recombinant IL-18 showed limited efficacy in clinical trials. A recent study showed the lack of efficacy was largely due to the existence of IL-18BP, a soluble decoy receptor for IL-18. It was shown that engineered IL-18 variants that maintained pathway activation
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LINC00641/miR-378a and Their Cross-Talk with TNF-α/IFN-γ as Potential Biomarkers in Ulcerative Colitis and Crohn's Diseases. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-11-01 Nour A Abdel Hameed,Olfat G Shaker,Nabil A Hasona
The most well-known forms of inflammatory bowel disease (IBD) that affect the entire gastrointestinal tract are ulcerative colitis (UC) and Crohn's disease (CD). The serum profile of inflammatory biomarkers and noncoding RNA and their role in the propagation of the inflammatory process remains controversial. Thus, this study was designed to examine the relationship between hematological profile, C-reactive
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High Anti-Interferon-Alpha Autoantibody Levels in Severe/Critical COVID-19 Patients from Peru. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-10-31 Maria J Pons,Ana Mayanga-Herrera,Luciano A Palomino-Kobayashi,Antonio M Quispe,Manuel F Ugarte-Gil
Innate immune responses through the production of type I interferon-α (anti-IFN-α) play an essential role in the defense against viruses. The autoantibodies (auto-Abs) anti-IFN-α are implicated in COVID-19 pathogenesis with higher levels among patients with worse prognoses. The study aimed to assess the levels of anti-IFN-α auto-Abs in Peruvian patients with severe/critical hospitalized COVID-19 compared
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TRPM2-L Participates in the Interleukin-6 Pathway to Enhance Tumor Growth in Prostate Cancer by Hypoxia-Inducible Factor-1α. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-10-31 Kai Cheng,Qingmei Jia,Christopher Batbatan,Zhihua Guo,Fengtao Cheng
Interleukin-6 (IL-6) can promote cell proliferation in prostate cancer (PCa). Full-length transient receptor potential melastatin 2 (TRPM2-L) is highly expressed in PCa. However, the association between IL-6 and TRPM2-L in PCa is unclear. Here, human PCa cell lines, PC-3 and DU-145, were treated with 10 μg/mL tocilizumab, an IL-6 receptor (IL-6R) inhibitor, and the TRPM2-L protein expression in cells
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Biology of Interleukin-17 and Novel Therapies for Hidradenitis Suppurativa. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-10-12 Robert Sabat,Johann Eli Gudjonsson,Nicolo Costantino Brembilla,Kelsey R van Straalen,Kerstin Wolk
Skin disorders affect ∼40% of the human population. One of the most debilitating cutaneous disorders is Hidradenitis suppurativa (HS), a noncommunicable chronic inflammatory disease with an estimated global prevalence of 0.4% to 2.5%. In January 2011, high levels of IL-17 were discovered in skin lesions of HS patients. In the following years, translational and clinical research led to a better understanding
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Proinflammatory Bone Marrow Mesenchymal Stem Cell-Derived Exosomal miR-150-3p Suppresses Proinflammatory Polarization of Alveolar Macrophages in Sepsis by Targeting Inhibin Subunit Beta A. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-10-11 Guojin Liang,Yueying Feng,Wan Tang,Lifeng Yao,Changshun Huang,Yijun Chen
Bone marrow mesenchymal stem cell (BMSC)-derived exosomes can protect lung tissues against sepsis, but its related mechanism remains elusive. BMSCs were primed with or without lipopolysaccharide (LPS) before extracting exosomes. The isolated exosomes were identified by transmission electron microscopy, nanoparticle tracking analysis, and western blot. LPS-stimulated macrophages were cocultured with
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Association Between Serum Chemokine Ligand 20 Levels and Disease Activity and Th1/Th2/Th17-Related Cytokine Levels in Rheumatoid Arthritis. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-10-09 Liuqing Wang,Xuelian Hong,Hongwei Du
Rheumatoid arthritis (RA) is a type of arthritis autoimmune disease characterized by systemic chronic inflammation. C-C Chemokine ligand 20 (CCL20) is the same as most chemokines with immunomodulatory and inflammatory processes. The correlation of CCL20 in RA remains unclear. This study aimed to explore the association among levels of CCL20, T helper cell (TH) subset (Th1/Th2/Th17)-related cytokine
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Call for Special Issue Papers: The "Yin-Yang" Activities of Tumor-Induced Inflammatory Cytokines for Cancer Immunotherapy, Detection and Prognosis. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-10-01 Yan Ma,Sanjay Mukherjee,Jing Ma
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The Role and Potential Regulatory Mechanism of STING Modulated Macrophage Apoptosis and Differentiation in Severe Acute Pancreatitis-Associated Lung Injury. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-10-01 Yiqiu Peng,Yingying Li,Yuxi Yang,Tingjuan Shi,Ruixia Liu,Yingyi Luan,Chenghong Yin
This study aims to investigate the role of STING in promoting macrophage apoptosis and regulating macrophage polarization in severe acute pancreatitis (SAP)-associated lung injury in vitro and in vivo. A murine model was established by intraperitoneal injection of caerulein and lipopolysaccharide (LPS). Meanwhile, ANA-1 cells were stimulated with LPS to induce apoptosis in vitro. More primary alveolar
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Annihilation of Non-small Cell Lung Cancer by NKG2D CAR-T Cells Produced from T Cells from Peripheral Blood of Healthy Donors. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-10-01 Jinhong Jiang,Yonghua Liu,Yuxiao Zeng,Bingmu Fang,Yongping Chen
Some progress has been made in immunotherapy with chimeric antigen receptor (CAR)-T cells targeting NKG2D-NKG2DL with the purpose of eradicating solid tumors. Non-small cell lung cancer (NSCLC) has been shown to express NKG2DL. This study hence evaluated the therapeutic effect of NKG2D CAR-T cells on NSCLC. Accordingly, NKG2D CAR-T cells were obtained from diverse human autologous T cell sources. T
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The Many Faces of Oligoadenylate Synthetases. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-09-25 Saumendra N Sarkar,Munesh K Harioudh,Lulu Shao,Joseph Perez,Arundhati Ghosh
2'-5' Oligoadenylate synthetases (OAS) are interferon-stimulated genes that are most well-known to protect hosts from viral infections. They are evolutionarily related to an ancient family of Nucleotidyltransferases, which are primarily involved in pathogen-sensing and innate immune response. Classical function of OAS proteins involves double-stranded RNA-stimulated polymerization of adenosine triphosphate
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Characterization of IL-10 Family of Cytokines in Acute and Convalescent COVID-19 Individuals. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-09-14 Anuradha Rajamanickam,Pavan Kumar Nathella,Nandhini Selvaraj,Murhekar Manoj,Jeromie Wesley Vivian Thangaraj,Santhosh Kumar Muthusamy,Girish Kumar Chethrapilly Purushothaman,Tarun Bhatnagar,Manickam Ponnaiah,Sabarinathan Ramasamy,Saravanakumar Velusamy,Subash Babu
Cytokines are major players in orchestrating inflammation, disease pathogenesis, and severity during COVID-19. Members of the interleukin (IL)-10 family of cytokines play important roles in regulating immune responses to various inflammatory and infectious diseases. However, the role of the IL-10 family of cytokines in COVID-19 remains elusive. Hence, we determined the plasma levels of the IL-10 family
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Deletion of Interferon Lambda Receptor Elucidates Susceptibility to the Murine Model of Biliary Atresia. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-09-01 Stephen J Hartman,Madeleine A Weiss,Haley M Temple,Bryan Donnelly,Rajamouli Pasula,Holly M Poling,Monica McNeal,Sujit K Mohanty,Greg M Tiao
Biliary atresia (BA) is a life-threatening cholangiopathy occurring in infancy, the most common indication for pediatric liver transplantation. The etiology of BA remains unknown; however, a viral etiology has been proposed as multiple viruses have been detected in explants of infants afflicted with BA. In the murine model of BA, Rhesus rotavirus (RRV) infection of newborn BALB/c pups results in a
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The Interferon-Lambda Family Celebrates 20 Years of Scientific Discovery. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-09-01 Raymond P Donnelly,Ludmila Prokunina-Olsson
It has now been 20 years since the original discovery of the interferon λ (IFN-λ) family (Kotenko et al., 2003; Sheppard et al., 2003) and 10 years since the subsequent discovery of IFN-λ4 (Prokunina-Olsson et al., 2013). The IFN-λ family (type III IFNs) includes 4 members: IFN-λ1, 2, 3, and 4, and all 4 of these proteins signal through the same heterodimeric receptor complex: IFN-λR1 plus IL-10R2
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Synthetic Heterodimers of Type III Interferon Receptors Require TYK2 for STAT Activation. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-09-01 Emily V Mesev,Emma G Guare,Alexander Ploss,Jared E Toettcher
Type III interferons (IFN-λ) are central to host defense against viral infection of epithelial barrier surfaces. IFN-λ binding to its receptor induces a JAK-STAT cascade through kinases Janus-associated kinase 1 (JAK1) and tyrosine kinase 2 (TYK2), which are associated on either subunit of the heterodimeric type III IFN receptor. Recent studies have shown that TYK2 is not necessary for IFN-λ to signal
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DNA-Dependent Interferon Induction and Lung Inflammation in Bordetella pertussis Infection. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-08-31 Jeremy Ardanuy,Karen M Scanlon,Ciaran Skerry,Nicholas H Carbonetti
Pertussis, caused by Bordetella pertussis, is a resurgent respiratory disease but the molecular mechanisms underlying pathogenesis are poorly understood. We recently showed the importance of type I and type III interferon (IFN) induction and signaling for the development of lung inflammation in B. pertussis-infected mouse models. Classically, these IFNs are induced by signaling through a variety of
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Correction to: A Specific Pattern and Dynamics of Circulating Cytokines Are Associated with the Extension of Lung Injury and Mortality in Colombian Adults with Coronavirus Disease-19, by Sara Bolívar-Marín, et al. J Interferon Cytokine Res 2023; (vol. 43, no. 5; 206-215); doi: 10.1089/jir.2023.0001. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-08-11
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Study on the Characteristics of Early Cytokine Storm Response to Cardiac Surgery. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-08-01 Danyang Zhao,Rongli Yang,Sibo Liu,Dong Ge,Xiaolei Su
Cardiac surgery can provoke an acute cytokine storm that may contribute to the development of postoperative multiple organ dysfunction syndrome. We prospectively observed patients undergoing cardiac surgery and divided them into two groups: the severe group and the mild group. Healthy individuals were enrolled acting as the control group for comparison. Plasma samples and clinical data were recorded
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Cytokines as Prognostic Biomarkers in Osteosarcoma Patients: A Systematic Review and Meta-analysis. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-08-01 Gang Liu,Ben Liu,BinBin Liu,Liyuan Tang,Zhiwei Liu,Haiyang Dai
Osteosarcoma is the most prevalent type of primary bone malignancy in children and adolescents. The effect of cytokines on osteosarcoma prognosis has been studied and reported. This meta-analysis aimed to assess the prognostic value of cytokines as osteosarcoma biomarkers. Databases including PubMed, Embase, and Cochrane Library were searched for studies on the prognostic value of cytokines in osteosarcoma
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Serum Cytokine Profiles in Patients with Rheumatoid Arthritis Before and After Treatment with Methotrexate. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-08-01 Manoj Lama,Rajat Sarkar,Bappaditya Ghosh
Rheumatoid arthritis (RA) is an inflammatory autoimmune illness affecting around 1% of the population globally. Cytokines have a crucial role in the pathogenesis of RA. The objectives of the present study were to compare the serum cytokine profiles between methotrexate (MTX)-treated and MTX-naive RA patient groups, MTX-treated RA patient group and healthy controls, and MTX-naive RA patient group and
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The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-08-01 Marjan Hesari,Zeinab Attar,Shakiba Soltani-Shirazi,Omid Keshavarzian,Reza Taheri,Reza Tabrizi,Hamed Fouladseresht
Interleukin-7 (IL-7) is essential for maintaining the immune system's defense functions by regulating the development and homeostasis of lymphocytes. Findings have shown the high efficacy of IL-7/IL-7 receptor (IL-7R)-based immunotherapy on various malignancies, with confirmation in both animal models and humans. In recent years, the progression-free survival and overall survival of patients suffering
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Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-07-27 Nicole A de Weerd,Olamide Ogungbola,Xinyun Liu,Antony Y Matthews,Amina Ismail,Julian P Vivian,San S Lim,D Lorne Tyrrell,Niru Putcha,Mike Skawinski,Harold Dickensheets,Thomas B Lavoie,Raymond P Donnelly,Paul J Hertzog,Deanna M Santer
Type III interferons (IFN-lambdas, IFN-λs) are important antiviral cytokines that can also modulate immune responses by acting through a heterodimeric receptor composed of the specific and limited expressed IFN-λR1 chain and the ubiquitous IL-10R2 chain, which is shared with IL-10 family cytokines. Conflicting data have been reported regarding which cells express the IFN-λR1 subunit and directly respond
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The Role of Interferon Receptors α/β/γ Ablation During Western Diet-Induced Obesity and Insulin Resistance in the Inflectional Model AG129 Mice Strain. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-07-10 Emylle Costa-Bartuli,Adrielle Tenório Rodrigues,Sofia Andrade Ribeiro Bastos,Nathan Kistenmacker,Leticia Crepaldi,Christina Maeda Takiya,Patricia Zancan,Fabio Mendonça Gomes,Mauro Sola-Penna
Diet-induced obesity triggers elevation of circulating pro-inflammatory cytokines and acute-phase proteins, including interferons (IFNs). IFNs strongly contribute to low-grade inflammation associated with obesity-related complications, such as nonalcoholic fat liver disease and diabetes. In this study, AG129 mice model (double-knockout strain for IFN α/β/γ receptors) was fed with a high-fat high-sucrose
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Altered Tumor Necrosis Factor Response in Neurologic Postacute SARS-CoV-2 Syndrome. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-06-29 Lao-Tzu Allan-Blitz,Jesse Goodrich,Howard Hu,Omid Akbari,Jeffrey D Klausner
Neurologic manifestations of postacute sequelae after SARS-CoV-2 infection (neuro-PASC) are common; however, the underlying drivers of those symptoms remain poorly understood. Prior work has postulated that immune dysregulation leads to ongoing neuroinflammation. We aimed to identify the cytokines involved in that immune dysregulation by comparing 37 plasma cytokine profiles among 20 case patients
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The Long-Awaited Respiratory Syncytial Virus Vaccine. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-06-27 John D Altman,Barry T Rouse
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IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-06-27 Francine S Baker,Jeanny Wang,Oscar Florez-Vargas,Nathan R Brand,Martin D Ogwang,Patrick Kerchan,Steven J Reynolds,Constance N Tenge,Pamela A Were,Robert T Kuremu,Walter N Wekesa,Nestory Masalu,Esther Kawira,Tobias Kinyera,Isaac Otim,Ismail D Legason,Hadijah Nabalende,George Chagaluka,Nora Mutalima,Eric Borgstein,George N Liomba,Steve Kamiza,Nyengo Mkandawire,Collins Mitambo,Elizabeth M Molyneux,Robert
Interferon lambda 4 (IFN-λ4) is a novel type-III interferon that can be expressed only by carriers of the genetic variant rs368234815-dG within the first exon of the IFNL4 gene. Genetic inability to produce IFN-λ4 (in carriers of the rs368234815-TT/TT genotype) has been associated with improved clearance of hepatitis C virus (HCV) infection. The IFN-λ4-expressing rs368234815-dG allele (IFNL4-dG) is
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IFNL4 Genotype Frequencies in Asian Populations Support Shorter Duration Therapy with Sofosbuvir-Based Hepatitis C Virus Regimens to Increase the Number Cured. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-06-22 Thomas R O'Brien,Mei-Hsuan Lee,Eleanor Wilson,Shyam Kottilil
Globally, ∼56.8 million people are chronically infected with hepatitis C virus (HCV), with about half residing in Asia. The cost and efficiency of delivering regimens based on direct-acting antiviral agents for HCV are important considerations in implementing these curative treatments. For sofosbuvir-based regimens, most patients are treated for 12 weeks; however, treatment for 8 weeks has been shown
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In Vitro Evaluation of Apoptosis, Inflammation, Angiogenesis, and Neuroprotection Gene Expression in Retinal Pigmented Epithelial Cell Treated with Interferon α-2b. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-06-08 Mehrdad Afarid,Hossein Bahari,Fatemeh Sanie-Jahromi
Angiogenesis, retinal neuropathy, and inflammation are the main molecular features of diabetic retinopathy (DR) and should be taken into consideration for potential treatment approaches. Retinal pigmented epithelial (RPE) cells play a major role in DR progression. This study evaluated the in vitro effect of interferon (IFN) α-2b on the expression of genes involved in apoptosis, inflammation, neuroprotection
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Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-06-08 Da'Kuawn Johnson,Nicholas Carbonetti
Type III interferon, or interferon lambda (IFNλ), was discovered 20 years ago and has been studied primarily for its role in combatting viral infections. However, it is also induced in response to certain bacterial infections but its roles and effects in this context are relatively poorly understood. In this mini review, we discuss the roles of IFNλ signaling in bacterial infections, highlighting its
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Circular RNA circTRAPPC6B Enhances IL-6 and IL-1β Expression and Repolarizes Mycobacteria Induced Macrophages from M2- to M1-Like Phenotype by Targeting miR-892c-3p. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-06-01 Ying Peng,Xian-Jin Wu,Xue-Jiao Ji,Gui-Xian Huang,Tian Wu,Xi Liu,Rui Yang,Jiang Pi,Hong-Bo Shen,Fei-Fei Wang,Jun-Fa Xu
Mycobacterium tuberculosis (Mtb) infection elicits macrophage polarization into M2 phenotype to block the host's protective immune response. However, it remains unclear how Mtb regulates macrophage polarization. Recent studies have suggested that noncoding RNA may play a role in macrophage polarization. In this study, we investigated the potential involvement of circTRAPPC6B, a circular RNA that is
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The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-06-01 Anthony Cannon,Abigail Pajulas,Mark H Kaplan,Jilu Zhang
Interleukin 9 (IL-9) is a cytokine with potent proinflammatory properties that plays a central role in pathologies such as allergic asthma, immunity to parasitic infection, and autoimmunity. More recently, IL-9 has garnered considerable attention in tumor immunity. Historically, IL-9 has been associated with a protumor function in hematological malignancies and an antitumor function in solid malignancies
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Autoantibodies Neutralizing Type III Interferons Are Uncommon in Patients with Severe Coronavirus Disease 2019 Pneumonia. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-05-29 Martti Vanker,Karita Särekannu,Arnaud Fekkar,Sofie Eg Jørgensen,Liis Haljasmägi,Anne Kallaste,Kalle Kisand,Margus Lember,Pärt Peterson,Madhvi Menon,Tracy Hussell,Sean Knight,James Moore-Stanley,Paul Bastard,Shen-Ying Zhang,Trine H Mogensen,Quentin Philippot,Qian Zhang,Anne Puel,Jean-Laurent Casanova,Kai Kisand
Autoantibodies (AABs) neutralizing type I interferons (IFN) underlie about 15% of cases of critical coronavirus disease 2019 (COVID-19) pneumonia. The impact of autoimmunity toward type III IFNs remains unexplored. We included samples from 1,002 patients with COVID-19 (50% with severe disease) and 1,489 SARS-CoV-2-naive individuals. We studied the prevalence and neutralizing capacity of AABs toward
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COVID-19 Severity Shifts the Cytokine Milieu Toward a Proinflammatory State in Egyptian Patients: A Cross-Sectional Study. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-05-26 Mohamed L Salem,Madonna M Eltoukhy,Rasha E Shalaby,Kamal M Okasha,Mohamed R El-Shanshoury,Mohamed A Attia,Mohamed S Hantera,Asmaa Hilal,Mohammed A Eid
Despite extensive research to decipher the immunological basis of coronavirus disease (COVID-19), limited evidence on immunological correlates of COVID-19 severity from MENA region and Egypt was reported. In a single-center cross-sectional study, we have analyzed 25 cytokines that are related to immunopathologic lung injury, cytokine storm, and coagulopathy in plasma samples from 78 hospitalized Egyptian
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A Meta-Analysis of the Association Between Genetic Polymorphisms in IL-12, IL-17, and IL-21 and Risk of Hepatitis B Virus Infection. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-05-01 Juan Wan,Li Tang,Hongyu Li,Ping Yang
Cytokine imbalance is an important feature in the occurrence and outcome of hepatitis B virus (HBV). Single nucleotide polymorphisms (SNPs) within cytokine genes may affect the protein expression and eventually contribute to the susceptibility of HBV infection. The association between interleukin (IL)-12, IL-17, or IL-21 and the risk of HBV infection has been extensively studied, but yielding equivocal
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A Specific Pattern and Dynamics of Circulating Cytokines Are Associated with the Extension of Lung Injury and Mortality in Colombian Adults with Coronavirus Disease-19. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-04-27 Sara Bolívar-Marín,Marcela Castro,Diego Losada-Floriano,Santiago Cortés,Federico Perdomo-Celis,Giovani Lastra,Carlos F Narváez
Increased systemic levels of inflammatory cytokines have been associated with the development of pathophysiologic events during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To further explore differences in the pattern and dynamics of plasma cytokines in individuals with coronavirus disease-19 (COVID-19), and the relationship with disease mortality, here we evaluated the
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Remote Ischemic Conditioning Relieves Necrotizing Enterocolitis Through Regulation of Redox and Inflammation. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-04-27 Yunfei Zhang,Qianyang Liu,Kai Gao,Bing Tian,Hai Zhu,Jian Liu,Yuhui Hu,Cuilian Ye,Chunbao Guo
In neonates, necrotizing enterocolitis (NEC) is a serious condition involving oxidative stress and inflammation. Remote ischemic conditioning (RIC) is a potentially useful technique to protect distant organs from the damage induced by ischemia. RIC has been verified as effective to protect against NEC; however, its mechanism is unclear. This study aimed to assess the mechanism and efficacy of RIC to
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Unexpected Need of the Epidermal Growth Factor Receptor Tyrosine Kinase Activity for Signaling by Intracellular Pattern Recognition Receptors of Nucleic Acids. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-04-21 Ganes C Sen,Patricia M Kessler
Many pattern recognition receptors in mammalian cells initiate signaling processes that culminate in mounting an innate protective response mediated by induced synthesis of a large number of proteins including type I interferons and other cytokines. Many of these receptors are not located on the plasma membrane but on the membranes of intracellular organelles such as endosomes, mitochondria, and the
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Plasma Markers for Early Prediction of Radiation-Induced Myocardial Damage. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-04-01 Yuanyuan Tao,Pei Li,Chenglong Zhao,Zhengshuai Mu,Yang Li,Shuanghu Yuan,Yuchun Wei
There is no sensitive and effective method to predict radiation-induced myocardial damage (RIMD). The aim of this study was to explore effective plasma biomarkers for early prediction of RIMD after radiotherapy (RT) in lung cancer patients and in a rat model. Biomarker levels were measured in plasma samples collected before and after thoracic RT from 17 lung cancer patients. For the animal model, a
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Acthar Gel Inhibits the Activation of CD4+ and CD8+ T Cells. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-04-01 Dale Wright,Kyle Hayes
Several inflammatory diseases are characterized by elevated T cell counts and high pro-inflammatory cytokine levels. Inhibiting T cell activity may reduce tissue damage associated with these diseases. Acthar® Gel has potent anti-inflammatory properties, yet little is known about its effect on T cells. This study compared the effects of Acthar, synthetic adrenocorticotropic hormone 1-24 (ACTH1-24) depot
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The Role of Inflammatory Cytokines (Interleukin-1 and Interleukin-6) as a Potential Biomarker in the Different Stages of COVID-19 (Mild, Severe, and Critical). J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-04-01 Mina Ghofrani Nezhad,Giti Jami,Omid Kooshkaki,Sajjad Chamani,Ali Naghizadeh
Cytokine storm refers to the overproduction of immune and inflammatory cells and their proteins (cytokines) [interleukin (IL)-1 and IL-6] causing acute respiratory distress syndrome in COVID-19. COVID-19 causes inflammatory reactions, and patients with COVID-19 had categorized as mild, severe, and critical after reviewing previous studies. Then, it is crucial to find immune-inflammatory indicators
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Tumor Necrosis Factor-Alpha/Tumor Necrosis Factor-Alpha Receptor 1 Signaling Pathway Leads to Thymocytes' Cell Death by Necroptosis in a Mouse Model of Acute Myeloid Leukemia. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-03-16 Meriem Ben Khoud,Nathalie Jouy,Virginie Driss,Bruno Quesnel,Carine Brinster
Acute myeloid leukemia (AML) is characterized by an increased proliferation and loss of differentiation of hematopoietic myeloid progenitors or precursors. Studies performed in AML-affected patients revealed a T cell deficiency characterized by a reduced thymic output and peripheral functional abnormalities. To assess for the thymus function during AML, we used an AML mouse model and showed a drastic
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A Novel Inactive Isoform with a Restored Reading Frame Is Expressed from the Human Interferon Lambda 4 TT Allele at rs368234815. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-03-07 Seema Bharatiya,Aditya Agarwal,Sreedhar Chinnaswamy
The TT allele of the dinucleotide variant rs368234815 (TT/ΔG) abolishes the open reading frame (ORF) created by the ancestral ΔG allele of the human interferon lambda 4 (IFNL4) gene, thus preventing the expression of a functional IFN-λ4 protein. While probing the expression of IFN-λ4 in human peripheral blood mononuclear cells (PBMCs), using a monoclonal antibody that binds to the C-terminus of IFN-λ4
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Prolonged Interferon-Stimulated Gene and Protein Signatures in Multiple Sclerosis Induced by PEGylated IFN-β-1a Compared to Non-PEGylated IFN-β-1a. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-03-03 Kristi Nguyen,Maya Olcer,Quentin Howlett-Prieto,Xuan Feng,Anthony T Reder
Interferon (IFN)-β-1a (Avonex) and longer half-life, polyethylene glycol-conjugated IFN-β-1a (PEG-IFN-β-1a, Plegridy), may generate different molecular responses. We identified different short-term and long-term in vivo global RNA signatures of IFN-stimulated genes in multiple sclerosis (MS) peripheral blood mononuclear cells and in selected paired serum immune proteins. At 6 h, non-PEGylated IFN-β-1a
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Interleukin-17 and Tumor Necrosis Factor Show a Functional Hierarchy to Regulate the Production of Matrix Metalloproteases by Monocytes from Patients with Psoriasis. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-03-01 Rashidi Springall,Maria Fernanda Ortega-Springall,Ana Elena Guerrero-Ponce,María Elisa Vega-Memije,Luis M Amezcua-Guerra
Interleukin-17 (IL-17) and tumor necrosis factor (TNF) regulate tissue remodeling through matrix metalloproteinases (MMPs). It is not yet clear whether these cytokines have a functional hierarchy in psoriasis. Serum levels of TNF (1,403 versus 1,058 pg/mL), IL-17 (1,528 versus 820 pg/mL), MMP-1 (1,999 versus 1,039 pg/mL), and MMP-9 (1,950 versus 1,561 pg/mL) were higher in psoriasis subjects (n = 60)
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Altered Expression of Vascular Cell Adhesion Molecule-1 in Oral Lichen Planus. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-03-01 Xiu-Li Zhang,Fang Wang,Gang Zhou
Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory mucocutaneous disease affected by the interaction between keratinocytes and T cells. Recent evidence indicates that vascular cell adhesion molecule-1 (VCAM1) plays a vital role in mediating immune and inflammatory responses. In this study, the expression of VCAM1 in OLP was detected by immunohistochemical staining and its correlations
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Darren P. Baker, PhD A Pioneer in the Development of Pegylated Interferon-β for Clinical Use. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-03-01 Raymond P Donnelly
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Molecular Dynamic Simulations Unravel the Underlying Impact of Missense Mutation in Autoimmunity Gene PTPN22 on Predisposition to Rheumatoid Arthritis. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-02-22 Usman Pasha,Haseeb Nisar,Hajira Nisar,Rizwan Abid,Naeem Mahmood Ashraf,Saima Sadaf
Genetic mutations in various proteins have been implicated with increased risk or severity of rheumatoid arthritis (RA) in different population groups. In the present case-control study, we have investigated the risk association of single nucleotide mutations present in some of the highly reported anti-inflammatory proteins and/or cytokines, with RA susceptibility in the Pakistani subjects. The study
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Analysis of Immune and Inflammatory Microenvironment Characteristics of Noncancer End-Stage Liver Disease. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-02-07 Yang Wang,Qi Wang,Tong Wang Yang,Ji Ming Yin,Feili Wei,Huan Liu,Peng Xiang Yang,Jiaxi Li,Ning Liu,Yunxia Zhu,Dexi Chen
Chronic liver injury eventually progresses to cirrhosis and end-stage liver disease (ESLD), which are the leading causes of death in patients with liver disease worldwide. ESLD has a variety of etiologies and a complex pathogenesis. This study analyzed the characteristics of ESLD by studying the immune microenvironment and inflammatory microenvironment of ESLD caused by 4 noncancer diseases, including
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The Role of Interferons in Long Covid Infection. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-02-01 Mohammad Karbalaeimahdi,Safar Farajnia,Nasrin Bargahi,Farzaneh Ghadiri-Moghaddam,Hamid Reza Rasouli Jazi,Nasim Bakhtiari,Samaneh Ghasemali,Nosratollah Zarghami
Although the new generation of vaccines and anti-COVID-19 treatment regimens facilitated the management of acute COVID-19 infections, concerns about post-COVID-19 syndrome or Long Covid are rising. This issue can increase the incidence and morbidity of diseases such as diabetes, and cardiovascular, and lung infections, especially among patients suffering from neurodegenerative disease, cardiac arrhythmias
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Anti-Tumor Necrosis Factor for Supplementary Management in Severe Asthma: A Systematic Review and Meta-analysis. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-02-01 Suhana Ahmad,Norhayati Mohd Noor,E A R Engku Nur Syafirah,Ahmad Adebayo Irekeola,Rafidah Hanim Shueb,Yean Yean Chan,Peter J Barnes,Rohimah Mohamud
Tumor-necrosis factor (TNF) is recognized as a therapeutic target in inflammatory diseases, including asthma. In severe forms of asthma, biologics such as anti-TNF are rendered to be investigated as therapeutic options in severe asthma. Hence, this work is done to assess the efficacy and safety of anti-TNF as a supplementary therapy for patients with severe asthma. A systematic search of 3 databases
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A Conversation with Dr. Alan Sher, PhD, NIH Distinguished Investigator. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-01-31
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Cytokines 2022: 10th Annual Meeting of the International Cytokine & Interferon Society. J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-01-25 Raymond P Donnelly
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Counteracting Interleukin-15 to Elucidate Its Modes of Action in Physiology and Pathology J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-01-17 Erwan Mortier, Mike Maillasson, Agnès Quéméner
Interleukin (IL)-15 belongs to the common gamma-dependent cytokine family, along with IL-2, IL-4, IL-7, IL-9, and IL-21. IL-15 is crucial for the homeostasis of Natural Killer (NK) and memory CD8 T cells, and to fight against cancer progression. However, dysregulations of IL-15 expression could occur and participate in the emergence of autoimmune inflammatory diseases as well as hematological malignancies
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Interferon-α2b-Induced RARRES3 Upregulation Inhibits Hypertrophic Scar Fibroblasts' Proliferation and Migration Through Wnt/β-Catenin Pathway Suppression J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-01-17 Xianglong Meng, Xinxin Gao, Kai Shi, Jingchun Zhao, Xiuhang Zhang, Xin Zhou, Xianjun Liu, Jiaao Yu
Hypertrophic scar (HS) is a severe skin fibrotic disorder with unclear pathogenesis. Interferon-α2b (IFN-α2b) exerts inhibitory effects on HS in vivo and in vitro; however, the exact mechanism remains unclear. In this study, we aimed to evaluate the inhibitory effects of IFN-α2b on hypertrophic scar fibroblasts' (HSFs) proliferation and migration, and to further investigate the associated molecular
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Comparison of the Antiviral Activity of Remdesivir, Chloroquine, and Interferon-β as Single or Dual Agents Against the Human Beta-Coronavirus OC43 J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-01-17 Brady T. Hickerson, Faruk Sheikh, Raymond P. Donnelly, Natalia A. Ilyushina
The human beta-coronavirus strain, OC43, provides a useful model for testing the antiviral activity of various agents. We compared the activity of several antiviral drugs against OC43, including remdesivir, chloroquine, interferon (IFN)-β, IFN-λ1, and IFN-λ4, in two distinct cell types: human colorectal carcinoma cell line (HCT-8 cells) and normal human bronchial epithelial (NHBE) cells. We also tested
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Hypoxia Attenuates Colonic Innate Immune Response and Inhibits TLR4/NF-κB Signaling Pathway in Lipopolysaccharide-Induced Colonic Epithelial Injury Mice J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2023-01-17 Ying Han, Ruhan Jia, Jingxuan Zhang, Qinfang Zhu, Xiaozhou Wang, Qiaorong Ji, Wei Zhang
High altitude hypoxia can lead to a spectrum of gastrointestinal problems. As the first line of host immune defense, innate immune response in the intestinal mucosa plays a pivotal role in maintaining intestinal homeostasis and protecting against intestinal injury at high altitude. This study aimed to investigate the effect of hypoxia on the colonic mucosal barrier and toll-like receptor 4 (TLR4)-mediated
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Plasma Macrophage Migration Inhibitory Factor Concentration at Each Spectrum of Tuberculosis J. Interferon Cytokine Res. (IF 2.3) Pub Date : 2022-12-13 Najdah -Hidayah, Irawaty -Djaharuddin, Ahyar -Ahmad, Sabar -Pambudi, Handayani -Halik, Subair -Subair, Andi -Tenriola, Andi Agus -Mumang, Nurjannah -Lihawa, Muhammad Nasrum -Massi
Macrophage migration inhibitory factor (MIF) is an inflammatory mediator in several diseases, including tuberculosis (TB). However, the role of MIF in each stage of TB remains to be further elucidated. Thus, this study aimed to analyze the differences in plasma MIF protein levels in patients with active pulmonary TB, positive and negative interferon-gamma release assay (IGRA) household contacts (HHCs)