Podocytes are an important component of the glomerular filtration barrier in the kidneys. The dysfunction and apoptosis of podocytes are important factors that can lead to the progression of chronic kidney disease (CKD). In CKD, angiotensin II is continuously elevated in circulation and is considered to have key roles in inducing podocyte injury and apoptosis. Curcumin is a hydrophobic polyphenolic

Vortioxetine is a potent antagonist of the 5‐hydroxytryptamine (5‐HT) receptor and serotonin transporter (SERT), and has been reported to function as an antidepressant for treatment of major depressive disorder (MDD). However, its antitumor effects remain unclear. Here, we examined whether vortioxetine affects the characteristics of GC cells. Cell viability was measured by colony formation assay and

Neointimal hyperplasia is a complicated inflammatory process contributing to vascular restenosis. This study aimed to explore whether chemokine‐like factor 1 (CKLF1) aggravates neointimal hyperplasia via the NF‐κB/VCAM‐1 pathway. We found the expression of CKLF1 and vascular cell adhesion molecule‐1 (VCAM‐1) significantly increased in human carotid plaques compared to control. In vivo , CKLF1 over‐expression

Abnormal gene expression is an established cause of gastric cancer (GC) initiation and progression. In this study, we aimed to identify several key genes that could be used to effectively predict progression and prognosis in patients with GC. The Cancer Genome Atlas and the Gene Expression Omnibus database were used to identify candidate genes. Fourteen genes were found to associate highly with progress

Poor immunogenicity of small proteins is a major hurdle in developing vaccines or producing antibodies for biopharmaceutical usage. Here, we systematically analyzed the effects of ten solubility controlling peptide tags (SCP‐tags) on the immunogenicity of a non‐immunogenic model protein, Bovine Pancreatic Trypsin Inhibitor (BPTI‐19A; 6 kDa). CD, fluorescence, DLS, SLS, and AUC measurements indicated

Transcriptional dynamics of cancer cells govern cell fate decisions and are therapeutically actionable drug targets. In this study, we engineered a circulating cancer cell line that secrets a luciferase reporter to capture constitutive and circadian clock driven transcription dynamics over the course of a day. Engineered human leukemic T‐cells (Jurkat) were observed to rhythmically secrete luciferase

When developing meaningful curricula, institutions must engage with the desired disciplinary attributes of their graduates. Successfully employed in several areas, including psychology and chemistry, disciplinary literacies provide structure for the development of core competencies‐ pursuing progressive education. To this end, we have sought to develop a comprehensive blueprint of a graduate biochemist

Hyperoside, as an active compound, widely exists in a large number of Chinese herbal medicines, and has been reported to possess anti‐inflammatory and diuretic properties. However, the effects and underlying mechanisms of hyperoside on periodontitis have not been previously reported. In the present study, we found that hyperoside ameliorates symptoms of periodontitis in a rat model, with improvements

The magnitude of the immune response is closely associated with clinical outcome in patients with cancer. However, finding potential therapeutic targets for lung cancer in the immune system remains challenging. Here we constructed a vital immune‐prognosis genes (VIPGs) based cluster of lung adenocarcinoma (LUAD) from IMMPORT databases and The Cancer Genome Atlas (TCGA). A transcription factor regulatory

Alzheimer’s disease (AD) afflicts millions of people worldwide and is caused by accumulated amyloid beta and tau pathology. Progression of tau pathology in AD may utilize prion mechanisms of propagation in which pathological tau aggregates released from one cell are taken up by neighboring or connected cells and act as templates for their own replication, a process termed “seeding.” We have used HEK293T

Activation induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of immunoglobulin genes in B cells while off‐targeted AID activity contributes to oncogenic mutations and chromosomal translocations associated with B cell malignancies. Paradoxically, only a minority of AID is allowed to access the nuclear genome but the majority of AID is retained in the cytoplasm