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Trained innate immunity Immunol. Res. (IF 2.507) Pub Date : 2021-01-16 Borros Arneth
The innate immune system acts rapidly in an identical and nonspecific way every time the body is exposed to pathogens. As such, it cannot build and maintain immunological memory to help prevent reinfection. Researchers contend that trained immunity is influenced by intracellular metabolic pathways and epigenetic remodeling. The purpose of this review was to explore the topic of trained innate immunity
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Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency Immunol. Res. (IF 2.507) Pub Date : 2021-01-06 Paria Kashani, Ashish Marwaha, Stephen Feanny, Vy Hong-Diep Kim, Adelle R. Atkinson, Matilde Leon-Ponte, Roberto Mendoza-Londono, Eyal Grunebaum
Single allele mutations in the Cell Division Control protein 42 homolog (CDC42) gene were recently shown to cause Takenouchi-Kosaki syndrome with diverse manifestations. These include persistent mild thrombocytopenia with large platelet size, severe developmental delay, growth retardation, facial dysmorphism, and other neurodevelopmental and hematological anomalies. CDC42 deficiency might also cause
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Tumor-infiltrating B cell is associated with the control of progression of gastric cancer Immunol. Res. (IF 2.507) Pub Date : 2020-11-24 Zhonglin Ni, Dong Xing, Teming Zhang, Ning Ding, Dan Xiang, Zhiguang Zhao, Jinmiao Qu, Changyuan Hu, Xian Shen, Xiangyang Xue, Jie Zhou
This study aimed to further explore the clinicopathological correlation of B cell infiltration in gastric cancer (GC) and its impact on prognostic. By immunohistochemical method, CD20+ B cells, CD3+ T cells, CD66b+ tumor-associated neutrophils, CD163+ tumor-associated macrophages, and CD57+ natural killer cells were analyzed in consecutive sections of 584 GC tissues and 69 normal adjacent tissues.
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Distorted frequency of dendritic cells and their associated stimulatory and inhibitory markers augment the pathogenesis of pemphigus vulgaris Immunol. Res. (IF 2.507) Pub Date : 2020-11-12 Dayasagar Das, Ashu Singh, Parul Singh Antil, Divya Sharma, Sudheer Arava, Sujay Khandpur, Alpana Sharma
The objective of this study was to investigate the frequency and functionality of DCs and its associated stimulatory and inhibitory markers in the pathogenesis of PV Active PV patients (n = 30) having both skin and oral lesions, and 30 healthy controls were recruited in the study. The frequency of DCs was determined by flow cytometry followed by the primary culture by using recombinant IL-4 (250 IU/ml)
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Long-term effects of intensive B cell depletion therapy in severe cases of IgG4-related disease with renal involvement Immunol. Res. (IF 2.507) Pub Date : 2020-11-10 Giacomo Quattrocchio, Antonella Barreca, Andrea Demarchi, Roberta Fenoglio, Michela Ferro, Giulio Del Vecchio, Carlo Massara, Cristiana Rollino, Savino Sciascia, Dario Roccatello
IgG4-related disease (IgG4-RD) is an immune-mediated disorder often showing elevated serum IgG4 concentrations, dense T and B lymphocyte infiltration, and IgG4-positive plasma cells and storiform fibrosis. We prospectively evaluated for 4 years 5 patients with histologically proven IgG4-RD of whom 3 had tubulointerstitial nephritis (TIN) and 2 had retroperitoneal fibrosis (RPF). They received an intensive
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Recent advances in therapeutic applications of neutralizing antibodies for virus infections: an overview Immunol. Res. (IF 2.507) Pub Date : 2020-11-08 Manasik Gumah Ali, Zhening Zhang, Qi Gao, Mingzhu Pan, Edward G Rowan, Juan Zhang
Antibodies are considered as an excellent foundation to neutralize pathogens and as highly specific therapeutic agents. Antibodies are generated in response to a vaccine but little use as immunotherapy to combat virus infections. A new generation of broadly cross-reactive and highly potent antibodies has led to a unique chance for them to be used as a medical intervention. Neutralizing antibodies (monoclonal
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PROMIS-29 survey confirms major impact of fatigue on health-related quality of life in common variable immunodeficiency Immunol. Res. (IF 2.507) Pub Date : 2020-11-08 Shouling Zhang, Myriam Kline, Ramsay L. Fuleihan, USIDNET Consortium, Christopher Scalchunes, Kathleen E. Sullivan, Artemio M. Jongco
Health-related quality of life (HRQOL) is an emerging topic of interest in patients with immunodeficiency. Information about HRQOL in common variable immunodeficiency (CVID) is limited. The primary objective was to compare primary immunodeficiency disease (PIDD) patients with and without common variable immunodeficiency (CVID) on HRQOL domains using Patient-Reported Outcomes Measurement Information
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Effects of whole-body cryotherapy on the innate and adaptive immune response in cyclists and runners Immunol. Res. (IF 2.507) Pub Date : 2020-11-07 Milena Nasi, Elena Bianchini, Domenico Lo Tartaro, Sara De Biasi, Marco Mattioli, Annamaria Paolini, Lara Gibellini, Marcello Pinti, Anna De Gaetano, Roberta D’Alisera, Laura Roli, Johanna Chester, Anna Vittoria Mattioli, Tomassina Polverari, Pasqualino Maietta, Ferdinando Tripi, Omar Stefani, Emanuele Guerra, Gustavo Savino, Tommaso Trenti, Andrea Cossarizza
The study aimed to identify the effects of whole-body cryotherapy (WBC) on immunological, hormonal, and metabolic responses of non-professional male athletes. Ten cyclists and ten middle-distance runners received 3 once-a-day sessions of WBC. Before initiating and after the final WBC session, a full set of hematologic parameters, serum chemistry profile, hormones, circulating mitochondrial (mt) DNA
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Patients with pemphigus are at an increased risk of developing rheumatoid arthritis: a large-scale cohort study Immunol. Res. (IF 2.507) Pub Date : 2020-11-07 Khalaf Kridin, Virginia A. Jones, Payal M. Patel, Shira Zelber-Sagi, Christoph M. Hammers, Giovanni Damiani, Kyle T. Amber, Arnon D. Cohen
Data regarding the association between pemphigus and rheumatoid arthritis (RA) is inconclusive and yet to be firmly established. In the current study, we aimed to evaluate the risk of developing RA during the course of pemphigus. A large-scale population-based longitudinal cohort study was conducted to evaluate the hazard ratio (HR) of RA among 1985 patients with pemphigus relative to 9874 age-, sex-
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Rectal cancer induces a regulatory lymphocytic phenotype in the tumor-draining lymph nodes to promote cancer cell installation Immunol. Res. (IF 2.507) Pub Date : 2020-11-04 Alexandra Giatromanolaki, Ioannis M. Koukourakis, Paschalis Chatzipantelis, Maria Kouroupi, Konstantina Balaska, Michael I. Koukourakis
Tumor-draining lymph nodes (TDLNs) are critical organs, where activation of B cells and T cells is orchestrated. Effector or regulatory anti-tumor immune responses are reflected by the composition of the lymphocytic and monocytic cell population of the node. Aside from the migratory cancer cell abilities, immune cell phenotypic changes in the TDLNs may define nodal invasion by cancer. We assessed the
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IL-21 enhances STAT3/Blimp-1 signaling pathway in B cells and contributes to plasma cell differentiation in newly diagnosed patients with myasthenia gravis Immunol. Res. (IF 2.507) Pub Date : 2020-11-03 Yanan Xu, Xiaoyu Huang, Fengzhan Li, Tan Liu, Tingting Yang, Fei Chen, Jie Zhu, Meng Pan, Yong Zhang, Yuzhong Wang, Linlin Fu, Chenghua Xiao, Deqin Geng
The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of Blimp-1 in MG. A total of 34 patients with MG (18 ocular MG (OMG) and 16 generalized
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Utility of serological biomarker’ panels for diagnostic accuracy of interstitial lung diseases Immunol. Res. (IF 2.507) Pub Date : 2020-10-22 Laura Bergantini, Miriana d’Alessandro, Lucia Vietri, Giuseppe Domenico Rana, Paolo Cameli, Silvia Acerra, Piersante Sestini, Elena Bargagli
Interstitial lung diseases (ILD) are a heterogeneous group of illnesses of known and unknown aetiology. Differential diagnosis among the three disorders is often challenging. Specific biomarkers with good sensitivity and specificity are therefore needed to predict clinical outcome and guide clinical decisions. The aim of this study was to investigate inflammatory/fibrotic biomarkers, to determine whether
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The relationships of serum homocysteine levels and traditional lipid indicators with disease activity and coronary artery involvement in Takayasu arteritis Immunol. Res. (IF 2.507) Pub Date : 2020-10-16 Si Chen, Haixia Luan, Jianxun He, Yan Wang, Xiaoli Zeng, Yongzhe Li, Hui Yuan
Serum homocysteine (HCY) levels have been associated with the occurrence of coronary stenosis and disease activity in large-vessel vasculitis. However, whether increases in serum HCY levels and traditional lipid indicators are associated with coronary artery involvement and disease activity in Chinese Han Takayasu arteritis (TA) patients is unknown. This study aims to investigate the clinical and laboratory
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Recent advances, approaches and challenges in targeting pathways for potential COVID-19 vaccines development Immunol. Res. (IF 2.507) Pub Date : 2020-10-01 Daniela Calina, Chandan Sarkar, Andreea Letitia Arsene, Bahare Salehi, Anca Oana Docea, Milon Mondal, Muhammad Torequl Islam, Alireza Zali, Javad Sharifi-Rad
During the COVID-19 pandemic in a modern era, there is a global consensus on the need for the rapid development of a vaccine against SARS-CoV-2 for effective and sustainable control. Developing these vaccines is fundamental to public health. This urgent need is supported by the scientific explosion in structural and genomic biology that facilitates the urgent development of an ideal COVID-19 vaccine
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Immune characteristics distinguish patients with severe disease associated with SARS-CoV-2 Immunol. Res. (IF 2.507) Pub Date : 2020-09-28 Xiaolei Li, Yang Liu, Junming Li, Longhua Sun, Jibin Yang, Fei Xu, Jing Zhou, Lagen Wan, Xinping Xu, Aiping Le, Wei Zhang
This single-center, retrospective study aimed to explore the immune characteristics of COVID-19 and biomarkers to predict the severity of this disease. Patients infected with SARS-CoV-2 (n = 215) treated at the First Affiliated Hospital of Nanchang University from January 24 to March 12, 2020, were included in the study and classified into severe and non-severe groups. Peripheral immunocyte count and
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PD-1 expression is elevated in monocytes from hepatocellular carcinoma patients and contributes to CD8 T cell suppression. Immunol. Res. (IF 2.507) Pub Date : 2020-09-25 Jin Yun,Genhua Yu,Pingping Hu,Yang Chao,Xingyu Li,Xiaobo Chen,Qichun Wei,Junfeng Wang
It is recently shown that PD-1 expression by immune cells of the myeloid lineage contributes to the suppression of antitumor immunity. The expression of PD-1 by antigen-presenting cells in hepatocellular carcinoma (HCC), a malignancy with high intratumoral PD-L1 expression, remained understudied. Here, we found that circulating monocytes from HBV-associated HCC patients upregulated PD-1 in a severity-dependent
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Anti-IL-6 receptor monoclonal antibody as a new treatment of endometriosis. Immunol. Res. (IF 2.507) Pub Date : 2020-09-17 Ahmed A El-Zayadi,Sara A Mohamed,Mohammad Arafa,Shereen M Mohammed,Abdelhady Zayed,Mohamed S Abdelhafez,Ahmed M Badawy
Many pro-inflammatory cytokines especially tumor necrotic factor alpha (TNFα), interleukin (IL)-1β, and IL-6 have crucial role in the pathogenesis of endometriosis. In this study, we investigated the immune-modulatory role of humanized anti-IL-6 receptor monoclonal antibodies in the treatment of endometriosis. This is a prospective, randomized, controlled, blinded study in which Sprague Dawley rats
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Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implications for the vaccine. Immunol. Res. (IF 2.507) Pub Date : 2020-09-18 Darja Kanduc,Yehuda Shoenfeld
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T cell receptor repertoires of ex vivo-expanded tumor-infiltrating lymphocytes from breast cancer patients. Immunol. Res. (IF 2.507) Pub Date : 2020-08-28 In Ah Park,Hajar Rajaei,Young-Ae Kim,Hyeonjin Lee,Heejae Lee,Jeong-Han Seo,Sun-Hee Heo,In Hye Song,Gyungyub Gong,Hee Jin Lee
A higher level of tumor-infiltrating lymphocytes (TILs) is associated with better prognosis in breast cancer patients. Adoptive transfer of lymphocytes coupled with conventional therapies has appealed to many clinicians and investigators as an effective treatment strategy for cancer patients, which necessitates efficient activation and expansion of cytotoxic T lymphocytes precisely targeting cancer
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Protectin DX ameliorates inflammation in sepsis-induced acute lung injury through mediating PPARγ/NF-κB pathway. Immunol. Res. (IF 2.507) Pub Date : 2020-08-26 Haifa Xia,Yangyang Ge,Fuquan Wang,Yu Ming,Zhouyang Wu,Jingxu Wang,Shujun Sun,Shiqian Huang,Ming Chen,Weimin Xiao,Shanglong Yao
Previous reports have demonstrated that the newly identified lipid mediator protectin DX (PDX) could effectively attenuate multiple organ injuries in sepsis. The aim of our study was to clarify whether PDX could improve acute lung injury (ALI) induced by sepsis and elucidate the relevant potential mechanism. After inducing sepsis by the cecal ligation and puncture approach, mice were treated with a
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The role of Th17 cells in psoriasis. Immunol. Res. (IF 2.507) Pub Date : 2020-08-22 Binbin Li,Liangliang Huang,Peng Lv,Xiang Li,Ge Liu,Yan Chen,Ziyu Wang,Xiaoxian Qian,Yixiao Shen,Yunman Li,Weirong Fang
T helper 17 (Th17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). However, the role of Th17 cells in psoriasis has not been clarified completely. Th17-derived proinflammatory cytokines including IL-17A, IL-17F, IL-21, IL-22, and IL-26 have a critical
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TNF, IL-6, and IL-10 cytokines levels and their polymorphisms in renal function and time after transplantation. Immunol. Res. (IF 2.507) Pub Date : 2020-08-18 Lorraine Vieira Alves,Suellen Rodrigues Martins,Ana Cristina Simões E Silva,Carolina Neris Cardoso,Karina Braga Gomes,Ana Paula Lucas Mota
Cytokine polymorphisms can influence their plasma levels and thus affect the immune response in renal transplantation. A total of 146 renal transplant recipients (RTR) were classified into groups according to the estimated glomerular filtration rate (R1: < 60 and R2: ≥ 60 mL/min/1.73 m2) and time after transplantation (T1: 1 to 24, T2: 25 to 60, T3: 61 to 120, and T4: > 120 months after transplantation)
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The role of competing mechanisms on Lck regulation. Immunol. Res. (IF 2.507) Pub Date : 2020-08-14 Sabin J Bozso,Jimmy J H Kang,Jeevan Nagendran
Lck is a Src-related protein tyrosine kinase that associates with CD4 and CD8 molecules and is essential to T cell development and T cell activation. Regulatory mechanisms of Lck are diverse and controversy exists regarding the importance of each mechanism. The balance of phosphorylation at the inhibitory and activating Tyr residues is maintained by a balance between CD45 and Csk and is dependent upon
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Comparative study between human mesenchymal stem cells and etanercept as immunomodulatory agents in rat model of rheumatoid arthritis. Immunol. Res. (IF 2.507) Pub Date : 2020-07-30 Heba El-Gendy,Salah El-Deen Hawass,Manal Awad,Mona Ahmad Mohsen,Maha Amin,Hussein Abdelaziz Abdalla,Samah Fouad,Ahmed Lotfy
To compare human adipose tissue mesenchymal stem cells (AT-MSCs) and etanercept as immunomodulatory agents for collagen-induced arthritis (CIA). CIA was induced by rats’ immunization with collagen type II (CII) in complete Freund’s adjuvant in days 0 and 7. Before the onset of CIA, prevention group received five doses of AT-MSCS intraperitoneally. After establishment of arthritis, rats received either
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Blockade of PD-1 and TIM-3 immune checkpoints fails to restore the function of exhausted CD8+ T cells in early clinical stages of chronic lymphocytic leukemia. Immunol. Res. (IF 2.507) Pub Date : 2020-07-24 Hadiseh Rezazadeh,Mojgan Astaneh,Mohsen Tehrani,Hadi Hossein-Nataj,Ehsan Zaboli,Ramin Shekarriz,Hossein Asgarian-Omran
Blocking antibodies targeting immune checkpoint molecules achieved invaluable success in tumor therapy and amazing clinical responses in a variety of cancers. Although common treatment protocols have improved overall survival in patients with chronic lymphocytic leukemia (CLL), they continue to relapse and progress. In the present in vitro study, the application of anti-PD-1 and anti-TIM-3 blocking
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Granulomatous inflammation in lymph nodes of the head and neck-a retrospective analysis of causes in a population with very low incidence of tuberculosis. Immunol. Res. (IF 2.507) Pub Date : 2020-07-17 Thomas Frank Flyger,Stine Rosenkilde Larsen,Anette Drøhse Kjeldsen
The purpose of this study was to investigate the risk of the patient having: (1) TB, (2) sarcoidosis, (3) atypical mycobacteria, or (4) malignant disease, if FNAC or histology from a cervical lymph node shows granulomatous inflammation (GI). And to elucidate clinical characteristics associated with these causes of GI, patients with a pathological diagnosis of GI in head and neck lymph nodes were identified
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COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy. Immunol. Res. (IF 2.507) Pub Date : 2020-07-17 Carlo Perricone,Elena Bartoloni,Roberto Bursi,Giacomo Cafaro,Giacomo Maria Guidelli,Yehuda Shoenfeld,Roberto Gerli
SARS-CoV-2 infection is characterized by a protean clinical picture that can range from asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display a severe pulmonary involvement and develop neutrophilia, lymphopenia, and strikingly elevated levels of IL-6. There is an over-exuberant cytokine release with hyperferritinemia leading to the idea that COVID-19 is part of
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Hyperprogressive disease in patients with advanced renal cell carcinoma: a new pattern of post-treatment cancer behavior. Immunol. Res. (IF 2.507) Pub Date : 2020-07-10 Zhong Zheng,Ke Wu,Zhixian Yao,Xingyu Mu,Hantao Wu,Weiguang Zhao,Leilei Cheng,Zhihong Liu
Renal cell carcinoma (RCC) is among the most common cancers of the genitourinary system. Once RCC has progressed to a high tumor stage, surgery is no longer the optimal option, and treatment with drugs is more suitable. However, a proportion of patients with advanced RCC (aRCC) experience accelerated progression following targeted therapy or immunotherapy, a condition known as hyperprogressive disease
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Association of genetic polymorphism of BCL-2 (rs2279115) with susceptibility to HCV-related hepatocellular carcinoma. Immunol. Res. (IF 2.507) Pub Date : 2020-07-04 Hanan S Ahmed,Essam A Wahab,Hoda A Elhady,Manal M Elgerby
Hepatitis C virus (HCV) infection is the main risk factor for chronic hepatitis (CHC), liver cirrhosis, and hepatocellular carcinoma (HCC). B cell lymphoma-2 (BCL-2) prevents apoptosis, and its overexpression could promote cancer cell survival. The purpose of this study is to evaluate the association of Bcl-2 gene polymorphism (rs2279115) and HCV-related HCC susceptibility. Two hundred and seventy
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Patients with radiation enteritis present regulatory T cell impairment associated with CTLA-4. Immunol. Res. (IF 2.507) Pub Date : 2020-07-03 Xufeng Gong,Genhua Yu,Zongchang Song,Shuqi Huang,Yan Hou,Ning Wang,Wei Zhao,Jingjing Ouyang,Zhengzhou Gu,Haili Hu,Lei Fei,Aixia Fu,Jingping Xia,Yuehua Ding
Radiation enteritis is one of the most common side effects of ionizing radiation in patients with pelvic cancers. Increasing amounts of evidence indicate that pro-inflammatory responses significantly contribute to the development of radiation enteritis. In this study, we investigated the association between T regulatory (Treg) cells and the risk of developing radiation enteritis in cervical cancer
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The ratio of CD163-positive macrophages to Iba1-positive macrophages is low in the intima in the early stage of cutaneous arteritis. Immunol. Res. (IF 2.507) Pub Date : 2020-06-23 Mikiko Kobayashi,Yuki Matsumoto,Hidetoshi Satomi,Ayako Tateishi,Maki Ohya,Ichiro Ito,Hiroyuki Kanno
The etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. Macrophages are among the major inflammatory cells involved in innate immunity and
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A novel mutation in RFXANK gene and low B cell count in a patient with MHC class II deficiency: a case report. Immunol. Res. (IF 2.507) Pub Date : 2020-06-23 Farhad Abolnezhadian,Razieh Dehghani,Sajad Dehnavi,Ali Khodadadi,Mojtaba Shohan
Recurrence of severe microbial infections results from a primary immunodeficiency disorder known as major histocompatibility complex class II deficiency or bare lymphocyte syndrome type II. Immunologic function is severely impaired due to the absence of MHC class II molecules on the surface of immune cells. Here, we report a 5-year-old boy with a novel homozygous mutation in RFXANK gene that negatively
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Increased expression of proinflammatory cytokines and iNOS in the neocortical microvasculature of patients with temporal lobe epilepsy. Immunol. Res. (IF 2.507) Pub Date : 2020-06-01 José Luis Castañeda-Cabral,Mónica E Ureña-Guerrero,Carlos Beas-Zárate,Adacrid Colunga-Durán,Maria de Los Angeles Nuñez-Lumbreras,Sandra Orozco-Suárez,Mario Alonso-Vanegas,Rosalinda Guevara-Guzmán,Maria A Deli,Luisa Rocha
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Anti-rod and ring antibodies in patients with chronic hepatitis C using direct-acting antivirals. Immunol. Res. (IF 2.507) Pub Date : 2020-06-14 Ana Beatriz da Silva Sacerdote,Norma Arteiro Filgueira,Silvana de Barros Barreto,Andréa Dória Batista,Edmundo Pessoa Lopes
Anti-rods and rings (anti-RR) antibody induction is related to the combination of interferon and ribavirin in the treatment of hepatitis C virus (HCV) infection. If the main factor leading to this autoimmune reaction is the combination of these drugs, is not well known, but in vitro studies shows that ribavirin alone can induce rods and rings structures. New direct-acting antivirals (DAAs) permit HCV
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Correction to: B7-H3 modulates endothelial cell angiogenesis through the VEGF cytokine. Immunol. Res. (IF 2.507) Pub Date : 2020-06-12 Huijun Lai,Zhongwen Sun,Jie Yang,Pingping Wu,Yundi Guo,Jing Sun
The order of authors’ affiliations in the published version of this article was not consistent with the order in the submitted manuscript due to typesetting
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Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses. Immunol. Res. (IF 2.507) Pub Date : 2020-06-11 Wenyue Song,Hongfen Li,Bingkun Jia,Zhenxi Wang,Qingsheng Liu,Guangping Yang,Xiaorong Li
Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Blood samples were collected from pediatric patients with food allergy (FA). The Th2 response
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COVID 19: a clue from innate immunity. Immunol. Res. (IF 2.507) Pub Date : 2020-06-10 Domenico Birra,Maurizio Benucci,Luigi Landolfi,Anna Merchionda,Gabriella Loi,Patrizia Amato,Gaetano Licata,Luca Quartuccio,Massimo Triggiani,Paolo Moscato
The recent COVID-19 pandemic has had a significant impact on our lives and has rapidly expanded to reach more than 4 million cases worldwide by May 2020. These cases are characterized by extreme variability, from a mild or asymptomatic form lasting for a few days up to severe forms of interstitial pneumonia that may require ventilatory therapy and can lead to patient death. Several hypotheses have
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Downregulation of B regulatory cells and upregulation of T helper 1 cells in children with Gaucher disease undergoing enzyme replacement therapy. Immunol. Res. (IF 2.507) Pub Date : 2020-06-10 Asmaa M Zahran,Mervat A M Youssef,Engy Adel Shafik,Zeinab Albadry M Zahran,Omnia El-Badawy,Amir M Abo Elgheet,Khalid I Elsayh
Gaucher disease (GD) involves a broad spectrum of immunological cells, including T helper (Th) cells and regulatory B cells (Bregs), which function to resolve the immune response and inhibit excessive inflammation. This study aimed to explore T helper cells, B cells, and Bregs in GD children undergoing enzyme replacement therapy (ERT). Our study included 20 GD patients; six patients were categorized
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Big data highlights the association between psoriasis and fibromyalgia: a population-based study. Immunol. Res. (IF 2.507) Pub Date : 2020-06-09 K Kridin,S Vanetik,G Damiani,A D Cohen
Data on the association between fibromyalgia syndrome (FMS) and psoriasis are scarce. We aimed to examine the association between FMS and psoriasis using a large-scale observational population-based study. This cross-sectional study analyzed data from a big computerized database to evaluate potential differences in the prevalence of psoriasis between patients with FMS and matched control subjects.
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Impact of interleukin IL-6 rs-1474347 and IL-10 rs-1800896 genetic polymorphisms on the susceptibility of HCV-infected Egyptian patients to hepatocellular carcinoma. Immunol. Res. (IF 2.507) Pub Date : 2020-06-04 Reham M Abd El-Baky,Helal F Hetta,Gopala Koneru,Marwa Ammar,Engy A Shafik,Dina A Mohareb,Muhammad Abbas El-Masry,Haidi K Ramadan,Mohamed Zakaria Abu Rahma,Michael A Fawzy,Moustafa Fathy
Hepatitis C virus (HCV) is considered leading cause of cirrhosis and hepatocellular carcinoma (HCC). We aimed to examine the association of IL-6 and IL-10 single-nucleotide polymorphisms with the progression of chronic HCV (CHC) infection to cirrhosis and HCC. For comparative purposes, four groups were enrolled; chronic HCV group (CHC, n = 22), HCV-related liver cirrhosis group (HCV-LC, n = 22), HCV-related
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Jeffrey's insights: Jeffrey Modell Foundation's global genetic sequencing pilot program to identify specific primary immunodeficiency defects to optimize disease management and treatment. Immunol. Res. (IF 2.507) Pub Date : 2020-05-27 Jessica Quinn,Vicki Modell,Jennifer Holle,Rebecca Truty,Swaroop Aradhya,Britt Johnson,Jordan Orange,Fred Modell
Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic and often life-threatening infections and/or life-threatening autoimmunity if not diagnosed and treated. Patients with a suspected PI, but without a genetic diagnosis, commonly undergo a diagnostic odyssey that is costly, time-consuming, and arduous. This delay in diagnosis prevents appropriate disease management
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Structural and molecular analyses of functional epitopes and escape mutants in Japanese encephalitis virus envelope protein domain III. Immunol. Res. (IF 2.507) Pub Date : 2020-05-22 Urmi Roy
The Japanese encephalitis virus (JEV) is one of the vector borne causes of encephalitis found in southeastern Asia. This positive single-stranded RNA virus is a member of the Flaviviridae family, which notably includes dengue, tick-borne, West Nile, Zika as well as yellow fever, and transmits to humans by infected mosquitos. The main site of interactions for antibodies against this virus is the envelope
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Association of autoimmune regulator gene polymorphism with susceptibility to rheumatoid arthritis in Egyptian population. Immunol. Res. (IF 2.507) Pub Date : 2020-05-12 Nermeen Hassan A Moneim,Mona Farouk Mansour,Hanan Hassan Omar,Marwa Mohamed Fouad,Lobna Metwally,Taghrid B El-Abaseri,Mai Mohamed Abdelnaby
The autoimmune regulator (AIRE) gene controls autoimmunity via its transcript AIRE protein that suppresses naïve T cells during central selection. The role of AIRE polymorphism in rheumatoid arthritis (RA) autoimmunity remains elusive. This study aimed to investigate the association of two selected SNPs, namely, rs760426 and rs2075876, with RA susceptibility in the Suez Canal Zone population. The study
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Heterophilic antibodies influence immunometric assay: a case report and reviews. Immunol. Res. (IF 2.507) Pub Date : 2020-04-01 Yao-Feng Hu,Shinn-Ying Ho
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Antigen-specific humoral responses against Helicobacter pylori in patients with systemic sclerosis. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 Georgios Efthymiou,Christos Liaskos,Theodora Simopoulou,Emmanouela Marou,Eleni Patrikiou,Thomas Scheper,Wolfgang Meyer,Dimitrios Daoussis,Lazaros I Sakkas,Dimitrios P Bogdanos
Helicobacter pylori (Hp) is a likely trigger of systemic sclerosis (SSc), but systemic antigen-specific antibody (Ab) responses in a well-defined cohort of SSc patients have not been thoroughly assessed. Line immunoassay and immunoblotting testing Abs against 15 Hp antigens were performed in 91 SSc patients and 59 demographically matched healthy controls (HCs). Results were validated in an independent
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TLR-2-mediated metabolic reprogramming participates in polyene phosphatidylcholine-mediated inhibition of M1 macrophage polarization. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 Ting-Ting Feng,Xiao-Ying Yang,Shan-Shan Hao,Fen-Fen Sun,Ye Huang,Qi-Si Lin,Wei Pan
This study aimed to investigate whether the classic hepatoprotective drug polyene phosphatidylcholine (PPC) regulates macrophage polarization and explores the potential role of TLR-2 in this process. In RAW264.7 macrophages and murine bone marrow-derived macrophages (BMDMs) stimulated by lipopolysaccharide (LPS), PPC significantly inhibited the production of IL-6, TNF-α, and the mRNA expression of
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A case of aberrant CD8 T cell-restricted IL-7 signaling with a Janus kinase 3 defect-associated atypical severe combined immunodeficiency. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 Aaruni Khanolkar,Jeffrey D Wilks,Guorong Liu,Bridget M Simpson,Edward A Caparelli,Dawn A Kirschmann,Jenna Bergerson,Ramsay L Fuleihan
Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T-B+NK-) due to mutations arising in the genes encoding the common γ chain or Janus Kinase 3 (JAK3). In rare circumstances, mutations in the JAK3 gene have been reported to cause atypical SCID that selectively
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History, extensive characterization and challenge of anti-tetanus serum from World War I: exciting remnants and deceived hopes : Centenarian IgGs lost their neutralization capacity. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 Nicolas Aubert,Marie Brachet-Botineau,Giulia Emi de Olivera Preto,Isabelle Benz-de Bretagne,Hervé Watier,Guillaume Brachet
During World War I (WWI), infectious diseases including tetanus were among the most important causes of death. Even though its efficacy was somewhat controversial before the war, tetanus antiserum played a key role in reducing the mortality of this disease. A vial of tetanus antiserum dating back from WWI, left behind on the French battlefield by the US Army, was borrowed from a private collection
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The case for severe combined immunodeficiency (SCID) and T cell lymphopenia newborn screening: saving lives…one at a time. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 Jessica Quinn,Jordan S Orange,Vicki Modell,Fred Modell
Severe combined immunodeficiency (SCID) is a group of syndromes resulting from genetic defects causing severe deficiency in T cell and B cell function. These conditions are life-threatening and result in susceptibility to serious infections. SCID is often fatal in the first year of life if not detected and properly treated. SCID and related T cell lymphopenias can be detected in newborns by a simple
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Follicular cytotoxic CD8 T cells present high cytokine expression, and are more susceptible to Breg-mediated suppression in non-small cell lung cancer. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 Qin-Yun Ma,Jun Chen,Jun Zhao
Tumor-infiltrating CD8 T cells are instrumental to antitumor immunity. In this study, we found that a subset of CXCR5-expressing CD8 T cells, termed follicular cytotoxic T (Tfc) cells, potently infiltrated the untreated tumors from non-small cell lung cancer (NSCLC) patients. On average, Tfc cells represented 14% of total tumor-infiltrating CD8 T cells and 6.6% of total tumor-infiltrating lymphocytes
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Paving the way towards universal treatment with allogenic T cells. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 Michelle H Townsend,Kelsey Bennion,Richard A Robison,Kim L O'Neill
With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimize the production of CAR T cells for easier patient access. CAR T cell therapy is a
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Correction to: Primary immunodeficiencies in Central and Eastern Europe-the power of networking Report on the activity of the Jeffrey Modell Foundation Centers Network in Central and Eastern Europe. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 A Sediva,M Bataneant,M Belevtsev,A Blaziene,P Ciznar,E Förster-Waldl,J Kelecic,J Marodi,E Naumova,G Nasrullayeva,K Ress,M Serban,B Sitkauskiene,B Toth,V Modell,F Modell,V Tenembaum,M Marković,T Avcin
Due to authors' internal mistake they have misspelled the name of one of the co-authors in this article.
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Is there an association between alopecia areata and systemic lupus erythematosus? A population-based study. Immunol. Res. (IF 2.507) Pub Date : 2020-02-01 Khalaf Kridin,Guy Shalom,Doron Comaneshter,Arnon D Cohen
The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was conducted comparing the prevalence of SLE among patients with AA and among age-, sex-,
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Promotion on NLRC5 upregulating MHC-I expression by IFN-γ in MHC-I-deficient breast cancer cells. Immunol. Res. (IF 2.507) Pub Date : 2019-12-01 Ming-Zhen Zhao,Yu Sun,Xiao-Feng Jiang,Li Liu,Li Liu,Li-Xin Sun
Breast cancer is the most dominant cancer in women and the second most frequent cancer in the general population worldwide. NLRC5 critically transactivates MHC class I (classically HLA-ABC in human) which is crucial for cancer immunosurveillance. But the expressional and functional impairments of NLRC5 have been found in many cancers as a major mechanism of immune evasion. Promotion of NLRC5 with the
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Autoantibodies against P29ING4 are associated with complex regional pain syndrome. Immunol. Res. (IF 2.507) Pub Date : 2019-12-01 N T Baerlecken,R Gaulke,N Pursche,T Witte,M Karst,M Bernateck
INTRODUCTION Complex regional pain syndrome (CRPS) is a complication following trauma or surgery and may be difficult to diagnose since biomarkers are lacking. Using protein array technology, we found antibodies binding to p29ING4, which we further characterized using ELISA. METHODS Thirty-six sera of early-stage type 1 CRPS, 66 sera of rheumatoid arthritis (RA), 53 sera of axial spondyloarthritis
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CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE. Immunol. Res. (IF 2.507) Pub Date : 2019-12-01 Ning Wang,Shuang Liang,Jingyi Jin,Liang Fang,Qianli Ma,Xian Wang,Yun Song,Lihua Chen
The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate experimental autoimmune encephalomyelitis (EAE) development. However, the molecular mechanisms
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A high-risk laboratory profile of antiphospholipid antibodies and thrombosis is associated with a large number of extra-criteria manifestations in obstetric antiphospholipid syndrome. Immunol. Res. (IF 2.507) Pub Date : 2019-12-01 Sebastián Udry,José Omar Latino,Cristina Belizna,Silvia Perés Wingeyer,Diego Santiago Fernández Romero,Gabriela de Larrañaga
Extra-criteria manifestations such as thrombocytopenia and livedo are described associated with antiphospholipid syndrome (APS) but are not included in the current classification criteria. Their clinical expression might be important, as they may be associated with a high-risk profile of antiphospholipid antibodies (aPL) and thrombosis. We evaluated the association between the presence of extra-criteria
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Blockade of TLR4 using TAK-242 (resatorvid) enhances anti-cancer effects of chemotherapeutic agents: a novel synergistic approach for breast and ovarian cancers. Immunol. Res. (IF 2.507) Pub Date : 2019-12-01 Bahareh Kashani,Zahra Zandi,Mohammad Reza Karimzadeh,Davood Bashash,Ali Nasrollahzadeh,Seyed H Ghaffari
It is believed that pathways of the immune system are responsible for eradicating cancer cells; however, their over-activation and also their ectopic expression in tumor cells and microenvironment are major contributors to tumor growth and chemoresistance. Toll-like receptor 4 (TLR4) pathway is an innate immune-related pathway which is usually overexpressed in tumor cells that leads to excessive pro-inflammatory
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Retained or altered expression of major histocompatibility complex class I in patient-derived xenograft models in breast cancer. Immunol. Res. (IF 2.507) Pub Date : 2019-12-01 In Hye Song,Young-Ae Kim,Hyeonjin Lee,Hye Seon Park,In Ah Park,Chan Kyu Sim,Myeong Sup Lee,Gyungyub Gong,Hee Jin Lee
The expression of major histocompatibility complex class I (MHC I) in tumor cells is regulated by interferon signaling, and it is an important factor in the efficacy of cytotoxic T cell-dependent immunotherapy. To determine the impact of immune cells in MHC I expression on tumor cells, we compared the expression of MHC I in tumor cells derived from primary breast cancers and patient-derived xenograft