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Meningothelial meningioma in an unusual site: Thinking out of the box Cytopathology (IF 1.493) Pub Date : 2020-11-28 Sudha Sharma; Kumar Sangam Shukla; Arvind Rajwanshi
Extracranial meningiomas presenting in the parotid region are rare and often cause diagnostic difficulty and confusion with a primary salivary gland neoplasm. Aspiration cytology with cell block is helpful, and immunohistochemistry on cell block can confirm the diagnosis.
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The benefits of the Papanicolaou Society of Cytopathology System for reporting pancreatobiliary cytology: A 2‐year review from a single academic institution Cytopathology (IF 1.493) Pub Date : 2021-01-07 Luka Ozretić; Alexandra V. Simonović; Michael L. Rathbone; Martin P.A. Young; Miguel A. Perez‐Machado
Endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) is an essential tool in the diagnosis of pancreatic lesions. The aim of this study was to evaluate the diagnostic accuracy of cytology from EUS‐FNA, to correlate the results with the corresponding histopathological diagnoses and to analyse the impact of retrospective assignment of the Papanicolaou Society of Cytopathology (PSC) reporting
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Unilateral solid‐cystic renal mass in an infant: Highlighting the cytological mimics Cytopathology (IF 1.493) Pub Date : 2021-01-05 Parikshaa Gupta; Nitin James Peters; Amita Trehan; Kirti Gupta
Clear cell sarcoma of the kidney (CCSK) is the second most common primary renal malignancy in children, accounting for 3%‐5% of all primary paediatric renal tumours. Owing to its well‐known histopathological diversity, it is one of the most commonly misdiagnosed renal tumours. Establishing a cytological diagnosis of CCSK is challenging due to its rarity as well as the lack of knowledge about its cytological
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Human papillomavirus‐associated small cell carcinoma with synchronous squamous cell carcinoma in the nasopharynx: Report of a rare case Cytopathology (IF 1.493) Pub Date : 2020-12-31 Weihong Ma; Guy Betts; Michael Dykes; Dominic St Leger; Alexandra Sargent; David Shelton; Miles Holbrook; Durgesh Rana
This is a very rare case of human papillomavirus‐associated small cell carcinoma with co‐existing conventional squamous cell carcinoma in the nasopharynx that is diagnosed by cytological evaluation.
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Atypical cytological presentation of granular cell tumour: Tumour‐associated fibrosis may affect fine‐needle aspiration cytology accuracy Cytopathology (IF 1.493) Pub Date : 2020-11-29 Giulio Vitagliano; Marco Montella; Immacolata Cozzolino; Carmine Alfano; Alfonso Barbato; Pio Zeppa; Alessandro Caputo
The cytological features of granular cell tumour (GCT) are generally quite typical but, in some cases, the fine needle aspiration cytology (FNAC) diagnosis of GCT may be difficult or impossible because of unusual sites of onset or equivocal cytological features. In this report, two GCTs with atypical FNAC features are described in order to investigate the causes and provide possible diagnostic tips
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EGFR mutation testing in cytology smears of advanced non‐small cell lung carcinomas: Practical applications in low‐resource laboratories Cytopathology (IF 1.493) Pub Date : 2020-11-19 Varsha Singh; Aruna Nambirajan; Prabhat Singh Malik; Kanwalpreet Kaur; Anant Mohan; Deepali Jain
Routine EGFR mutation testing on cytology smears can be incorporated in daily practice in resource‐constrained settings where cell‐block and laser‐capture microdissection facilities are not available.
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DNA ploidy measurement and human papillomavirus in abnormal cervical cytology Cytopathology (IF 1.493) Pub Date : 2020-11-20 Ane Francyne Costa; Adriane Pogere; Ana Paula Beltrame Farina Pasinato; Edson Jose Monteiro Bello; Alexandre Sherlley Casimiro Onofre; Fabiana Botelho de Miranda Onofre
To compare the efficacy of high‐risk human papillomavirus (HR‐HPV) and DNA image cytometry (DNA‐ICM) status for identifying high‐grade cervical intraepithelial neoplasia or worse (≥CIN2).
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Implementation of pre‐captured videos for remote diagnosis of cervical cytology specimens Cytopathology (IF 1.493) Pub Date : 2020-12-24 Stavros Archondakis; Maria Roma; Evropi Kaladelfou
The objective of this study was to investigate the feasibility of implementing short videos captured by static telecytological applications for remote evaluation of cervical smears prepared by means of liquid‐based cytology.
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Diagnosis of prostate cancer in one day: The benefits of cytology in tumour detection Cytopathology (IF 1.493) Pub Date : 2020-10-26 Eva Compérat; Raphaele Renard‐Penna; Valérie Ondet; Géraldine Cancel‐Tassin; Olivier Cussenot
Prostate cancer (PCa) is a frequent and mortal disease. The aim of this study was to introduce a “diagnosis and handling of PCa in one day” concept, accelerating the handling of PCa patients by giving diagnostic results within 3 hours with the help of prostate cytology. Standard histology served as the control.
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Thyroid metastasis of pulmonary adenocarcinoma with EGFR G719A mutation: Genetic confirmation with liquid‐based cytology specimens Cytopathology (IF 1.493) Pub Date : 2020-11-13 Yosuke Yamada; Hiroyuki Shirahase; Mika Fukiya; Akihiko Yoshizawa; Sachiko Minamiguchi; Hiroaki Ozasa; Hironori Haga
We present a case of advanced pulmonary adenocarcinoma and a thyroid tumour with calcification. EGFR gene mutation test of the thyroid aspirate specimen revealed a G719A point mutation in exon 18 that was identical to that in the patient's known lung cancer. Our case demonstrates the usefulness of liquid‐based cytology samples, which enable genetic testing leading to a conclusive diagnosis while preserving
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A rare case of pleural localisation of both metastatic Merkel cell carcinoma and chronic lymphocytic leukaemia Cytopathology (IF 1.493) Pub Date : 2020-12-02 Elise Kaspi; Shirley Fritz; Julien Colle; Florent Amatore; Diane Frankel; Patrice Roll
A rare case of a pleural fluid cytological analysis revealing synchronous Merkel cell carcinoma and chronic lymphocytic leukaemia is presented with differential diagnosis.
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The emerging role of deep learning in cytology Cytopathology (IF 1.493) Pub Date : 2020-11-22 Pranab Dey
Deep learning (DL) is a component or subset of artificial intelligence. DL has contributed significant change in feature extraction and image classification. Various algorithmic models are used in DL such as a convolutional neural network (CNN), recurrent neural network, restricted Boltzmann machine, deep belief network and autoencoders. Of these, CNN is the most commonly used algorithm in the field
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The utility of fine needle aspiration cytology in orbital haematolymphoid neoplasms Cytopathology (IF 1.493) Pub Date : 2020-10-30 Norton Stephen; Prabhu Manivannan; Debasis Gochhait; Jinkala Sreerekha; Niranjini Ramasubramanian; Bheemanathi Hanuman Srinivas; Rakhee Kar; Nirupama Kasturi; Debdata Basu; Neelaiah Siddaraju
Orbital hematolymphoid lesions are rare and usually encountered in elderly patients. Orbital lesions are not easy to biopsy: hence fine needle aspiration cytology (FNAC) can be a very good diagnostic modality for these lesions.
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Cytological features of metastatic ceruminous adenocarcinoma (not otherwise specified) in pleural effusion: A case report Cytopathology (IF 1.493) Pub Date : 2020-11-13 Zhihua Lan; Jianping Li; Fang Yang
This is the first presentation of the cytological features of metastatic ceruminous adenocarcinoma(NOS)in a pleural effusion sample. Positive expression of SOX‐10 aided diagnosis in this case.
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Diagnostic utility of fine needle aspiration cytology and core biopsy histopathology with or without immunohistochemical staining in the subtyping of the non‐small cell lung carcinomas: Experience from an academic centre in Turkey Cytopathology (IF 1.493) Pub Date : 2020-11-03 Büşra Yaprak Bayrak; Nadir Paksoy; Çiğdem Vural
This retrospective morphological study compared the results of fine needle aspiration (FNA) cytology, haematoxylin‐eosin (HE)‐stained samples and immunohistochemical (IHC)‐stained core needle biopsy (CNB) histology samples for primary non‐small cell lung cancer (NSCLC) subtyping. We assessed the diagnostic utility of these methods to investigate the contribution of each method to NSCLC subtyping. We
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Solitary fibrous tumour of the submandibular gland: Novel insights from clinical practice on a close mimicker of pleomorphic adenoma and a diagnostic challenge for the cytopathologist Cytopathology (IF 1.493) Pub Date : 2020-10-26 Maria F. Gonzalez; Batool H. Husain
Spindle cell lesions of the salivary glands are rare and account for less than 3% of the salivary gland aspirates. A definitive classification of salivary gland neoplasms by fine needle aspiration is possible for the most common lesions but remains a challenge for the less common entities. We present a case of a 72‐year‐old male with a solitary fibrous tumour (SFT) of the submandibular gland mimicking
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Comparison of Afirma Gene Expression Classifier with Gene Sequencing Classifier in indeterminate thyroid nodules: A single‐institutional experience Cytopathology (IF 1.493) Pub Date : 2020-10-03 Yipeng Geng; Josephine S. Aguilar‐Jakthong; Neda A. Moatamed
The Afirma test has been used in the diagnosis of cytologically indeterminate thyroid nodules to reduce diagnostic uncertainty and unnecessary surgeries. Gene Sequencing Classifier (GSC) was developed to improve the positive predictive value and overall test performance of Gene Expression Classifier (GEC). Here we present our experience comparing the performance of first‐generation assay of Afirma
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Pulmonary sclerosing pneumocytoma mimicking malignancy in endobronchial ultrasound‐guided transbronchial needle aspiration: A case report Cytopathology (IF 1.493) Pub Date : 2020-11-06 Konstantinos Kosmas; Ioannis Vamvakaris; Eleni Psychogiou; Panagiotis Megas; Dimitra Riga
Although (PSP) it is generally considered to be a benign tumor, it represents a diagnostic challenge due to its controversial etiology and biologic behavior, the diversity of histopathohistological findings as well as the difficult differential diagnosis from poorly lung adenocarcinomas or carcinoids. EBUS‐TBNA alone cannot be accepted as the final definitive diagnostic approach for this tumor especially
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Juggling the COVID‐19 pandemic: A cytopathology point of view Cytopathology (IF 1.493) Pub Date : 2020-11-03 Antonino Iaccarino; Pasquale Pisapia; Elena Vigliar; Philippe Vielh; Giancarlo Troncone
Since its first identification in China at the end of 2019, severe acute respiratory syndrome coronavirus 2 has rapidly spread all over the world, becoming an international healthcare emergency. In the era of coronavirus disease‐2019 (COVID‐19), several aspects of normal life, including those related to the medical activities, have been radically changed. Extraordinary measures have been adopted by
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Impact of cytological pitfalls in the Bethesda System of Reporting Thyroid Cytopathology, on surgical decision‐making of patients with thyroid nodules: Can these pitfalls be avoided? Cytopathology (IF 1.493) Pub Date : 2020-10-26 Chanchal Rana; Kul Ranjan Singh; Pooja Ramakant; Suresh Babu; Anand Mishra
The purpose was to assess diagnostic accuracy of the Bethesda System of Reporting Thyroid Cytopathology, reasons for disagreement and cytological pitfalls with impact on surgical decisions in patients with thyroid nodules.
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Cytological diagnosis of osteosarcoma with emphasis on diagnostic pitfalls Cytopathology (IF 1.493) Pub Date : 2020-10-22 Parikshaa Gupta; Nalini Gupta; Vani Bharani; Rajesh Kumar; Nandita Kakkar; Pranab Dey; Radhika Srinivasan; Arvind Rajwanshi
Fine needle aspiration is a well‐established technique for evaluating primary and secondary bony lesions. With use in selected cases, it achieves a diagnostic yield comparable to biopsies.
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Is the use of the atypical squamous cells of undetermined significance category still necessary in cytological triage? Cytopathology (IF 1.493) Pub Date : 2020-10-22 Massimo Confortini
The balance point between the specificity and sensitivity obtainable in triage cytology must take into account that the first is the crucial point for the whole process of cervical cancer screening using HPV primary screening test. Having the use of HPV as primary screening test completely changed the role of the Pap test in the screening algorithm, should “The Bethesda System for Reporting Cervical
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Invasive fungal disease of the central nervous system: Challenging diagnosis of a rare fungus by intraoperative squash cytology Cytopathology (IF 1.493) Pub Date : 2020-10-27 Jai Kumar Chaurasia; Bitan Naik; Ashwani Tandon; Karuna Tadepalli; Ujjawal Khurana; Neelkamal Kapoor
This case report describes invasive fungal disease of CNS due to a rare hyalohyphomycotic fungus, diagnosed by intraoperative squash cytology and deals with diagnostic challenges involved in the differential diagnosis.
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Clinical and morphological spectrum of cutaneous metastases on cytology: A study of 225 cases Cytopathology (IF 1.493) Pub Date : 2020-10-30 Gargi Kapatia; Saumya Sahu; Manish Rohilla; Parikshaa Gupta; Nalini Gupta; Radhika Srinivasan; Arvind Rajwanshi; Pranab Dey
Any type of cutaneous metastasis indicates dismal outcome of the disease. Skin is an unusual location for metastatic deposits from any tumour and has an incidence of about 0.8%‐5%. Fine needle aspiration cytology (FNAC) helps in the rapid diagnosis of metastasis with minimum pain.
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Thyroid cytology in Pakistan: An institutional audit of the atypia of undetermined significance/follicular lesion of undetermined significance category Cytopathology (IF 1.493) Pub Date : 2020-10-24 Saira Fatima; Rabia Qureshi; Sumbul Imran; Romana Idrees; Zubair Ahmad; Naila Kayani; Arsalan Ahmed
Fine needle aspiration cytology (FNAC), along with thyroid ultrasound, is an important tool in evaluation of thyroid nodules that helps in further management of these patients in making a decision of surgical intervention vs follow‐up. The Bethesda System for Reporting Thyroid Cytopathology category III of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS)
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Liquid‐based shaking of core needle biopsy samples for the molecular characterisation of tumours: A fallback in cytopathology Cytopathology (IF 1.493) Pub Date : 2020-10-22 Vincenzo L'Imperio; Lilia Corral; Fabio Pagni
Cytological specimens may be the ideal source of nucleic acids for the molecular characterization of tumors in the next generation sequencing (NGS) era. Liquid‐based shaking of core needle biopsy samples could enhance the diagnostic yield, allowing additional material to be examined in parallel with histopathology.
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Bilateral renal masses in an adult with haematuria Cytopathology (IF 1.493) Pub Date : 2020-10-16 Parikshaa Gupta; Aditya Prakash Sharma; Jeni Mathew; Arvind Rajwanshi
Renal angiomyolipoma (AML) is a rare, benign mesenchymal neoplasm which can occur sporadically or in association with tuberous sclerosis complex. In the absence of typical radiologic features, a definitive diagnosis of AML requires microscopic examination of the tumor tissue supplemented by cell‐block immunocytochemistry.
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Effusion cytology of a mucinous borderline ovarian tumour: Pitfall or controversy? A case report with insight into the newly proposed International System for Reporting Serous Fluid Cytology Cytopathology (IF 1.493) Pub Date : 2020-10-22 Rubina Razack; Mokoena Martins Mohosho; Pieter Barnardt; Pawel Tomasz Schubert
A case report of effusion cytology of a mucinous neoplasm is illustrated. The authors share their insight into adapting the newly proposed international system for reporting serous fluid cytology.
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Ovarian pulmonary‐type small cell carcinoma diagnosed by means of ascitic fluid cytology: A case report with immunocytochemical analysis Cytopathology (IF 1.493) Pub Date : 2020-09-28 Akira Ishikawa; Hiroki Fujisawa; Naoko Yasumura; Kazuya Kuraoka; Junichi Zaitsu; Akihisa Saito; Arisa Kan; Kazue Iwahiro; Fumika Kimura; Hiroko Nakamura; Tomoya Mizunoe; Kiyomi Taniyama
Primary ovarian small cell carcinomas of pulmonary type are very rare neoplasms. This report describes an extraordinary case of small cell carcinomas of pulmonary type accurately diagnosed on cytology.
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Cytology of a temporal swelling in a young adult with unilateral conductive hearing loss Cytopathology (IF 1.493) Pub Date : 2020-10-11 Pankaj Kumar; Parikshaa Gupta; Neeraj Sharma; Chirag Kamal Ahuja; Arvind Rajwanshi
Giant‐cell tumour involving the calvarial bones is extremely rare. This case of a young man with unilateral hearing loss and earache associated with a mass over the temporal region was accurately diagnosed pre‐operatively by fine needle aspiration cytology. Knowledge of the characteristic cytological features can help to distinguish it pre‐operatively from its radiological mimics.
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The phosphatase PTPN1/PTP1B is a candidate marker of better chemotherapy response in metastatic high‐grade serous carcinoma Cytopathology (IF 1.493) Pub Date : 2020-10-06 Ben Davidson; Annika Jøntvedt Bock; Arild Holth; Dag Andre Nymoen
To analyse the expression and clinical role of the phosphatase PTPN1 (PTP1B) in serous effusions.
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Application of multicolour flow cytometry in the detection of metastatic carcinoma in serous effusions: Special emphasis in atypical cytology Cytopathology (IF 1.493) Pub Date : 2020-10-11 Saumya Sahu; Parikshaa Gupta; Shaily Susheilia; Upasana Gautam; Pranab Dey
We evaluated the role of simultaneous use of multiple antibodies in flow cytometry (FCM) to detect metastatic carcinomas in effusion samples.
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Lesion-targeted cytology to improve cytological sampling for atypical polypoid adenomyomas of the uterus: A case series and review of the literature. Cytopathology (IF 1.493) Pub Date : 2020-08-11 Makiko Omori,Masataka Kawai,Tatsuyuki Ogawa,Satoko Sasatsu,Hiroko Fukasawa,Kumiko Nakazawa,Tetsuo Kondo,Shuji Hirata
Atypical polypoid adenomyomas (APAs) are uncommon tumours consisting of atypical endometrioid glands and fibromyomatous stroma. Identifying the biphasic nature of atypical glandular components and spindle mesenchymal components without atypia is crucial for the cytological diagnosis of APA. We investigated the utility of lesion‐targeted cytology (LTC) to directly collect firm spindle components.
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Cerebrospinal fluid cytology in a young adult with seizures. Cytopathology (IF 1.493) Pub Date : 2020-08-31 Aleena Jain,Parikshaa Gupta,Gaurav Prakash,Savita Kumari,Radhika Srinivasan
Involvement of the central nervous system (CNS) by anaplastic large cell lymphoma (ALCL) is rare, most being primary CNS ALCL with only occasional reports of CNS involvement in systemic ALCL. Establishing a diagnosis of CNS infiltration by systemic ALCL is difficult but carries immense prognostic significance. This report presents a such a case, diagnosed on CSF cytology complemented by CSF flow cytometry
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Unilateral axillary lymph node metastasis from small cell neuroendocrine carcinoma of Urinary bladder. Cytopathology (IF 1.493) Pub Date : 2020-09-16 Suvradeep Mitra,Suvendu Purkait,Manoj Kumar Das
The case describes the unusual scenario of unilateral axillary lymph node metastasis from a small cell neuroendocrine carcinoma of urinary bladder. The diagnosis is challenging because of the unusual primary site.
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Myoepithelial sialadenitis with metachromatic matrix: a diagnostic pitfall. A case of salivary gland swelling in paediatric patient evaluated by Fine Needle Aspiration Cytology. Cytopathology (IF 1.493) Pub Date : 2020-09-15 Andrea Ronchi,Marco Montella,Paola Martina Marra,Giuseppe Colella,Renato Franco,Immacolata Cozzolino
Fine needle aspiration cytology (FNAC) is generally characterized by a high diagnostic accuracy in differentiating non‐neoplastic/inflammatory lesions from neoplastic lesions of the salivary glands. Lymphoepithelial sialadenitis/myoepithelial sialadenitis is exceedingly rare in paediatric patients and is characterized by a diffuse, often bilateral, salivary gland enlargement and the differential diagnosis
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Corpora amylacea in sputum smears: Incidence and clinical significance Cytopathology (IF 1.493) Pub Date : 2020-09-28 Rafael Martínez‐Girón; Liron Pantanowitz
To examine conventional sputum smears for the presence of corpora amylacea (CA), determining their incidence and clinical significance.
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Thyroid nodules 1 cm or less are related to Bethesda System nondiagnostic and suspicious for malignancy categories. Cytopathology (IF 1.493) Pub Date : 2020-09-18 Felipe Abrantkoski Borges,Deolino João Camilo-Júnior,José Cândido Caldeira Xavier-Júnior
To compare the frequency of fine needle aspiration (FNA) cytological results between nodules 1 cm or less and nodules greater than 1 cm.
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Comparative Cytologic and Histologic Assessment of 828 Primary Soft Tissue and Bone Lesions and Proposal for a System for Reporting Soft Tissue Cytopathology. Cytopathology (IF 1.493) Pub Date : 2020-09-14 Jan Köster,Iman Ghanei,Henryk A Domanski
The aim of the study was to evaluate the diagnostic utility of fine needle aspiration (FNA) cytology and core needle biopsies (CNBs) in a series of primary soft tissue and bone lesions and to test a possible system for reporting results of FNA cytology of soft tissue lesion.
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Preservation of biomarkers immunoreactivity on cytospins protected with polyethylene glycol. Cytopathology (IF 1.493) Pub Date : 2020-09-10 Irena Srebotnik Kirbis,Maria José Praça,Ruben Rodrigues Roque,Tina Košuta,Saudade André,Margareta Strojan Flezar
The aim of this retrospective study was to evaluate the preservation of biomarkers immunoreactivity on cytospins protected with polyethylene glycol (PEG).
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Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) of pancreatic mass. Cytopathology (IF 1.493) Pub Date : 2020-09-07 Maleka Najmi,Meenakshi Manivannan,Nawar Hakim,Syed M Gilani,Niti Manglik
The majority of pancreatic tumours are epithelial and primary in origin, although occasionally secondary tumours from kidney, lung, breast and gastrointestinal tract can involve the pancreas. Discussed here, is fine needle aspiration cytology of a pancreatic mass in a 59‐year‐old male.
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What is Thy3a? A study of 336 Thy3a (AUS/FLUS) thyroid FNAs with histology compares UK RCPath with other reporting systems and shows how Thy3a subclassification can improve risk stratification and help address overuse of this category. Cytopathology (IF 1.493) Pub Date : 2020-09-06 Cynthia van,der Horst,Sylvia Wright,David Young,Hitesh Tailor,Louise Clark
Thy3a (AUS/FLUS) is an indeterminate and heterogeneous category in thyroid cytology. Thy3a reporting rates vary widely, with many laboratories documenting overuse. Subclassification of Thy3a helps with risk stratification. We aimed to investigate whether subclassification can also help address Thy3a overuse. We compare the UK reporting system with other terminologies.
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Comparison of the quality of the microwave cell block method with the conventional cell block method in processing body fluid samples. Cytopathology (IF 1.493) Pub Date : 2020-09-04 Chippy Jayakumar,Jinkala Sreerekha,Debasis Gochhait,Prasanna Venkadesa Perumal,Srikanta Kanungo,Neelaiah Siddaraju,Samanyoya Gochhait,Lakshmi Ramatchandrin
Conventional cell blocks (CCB) prepared from cytological specimens are very useful but the method is relatively time‐consuming. Suitable modifications in cell‐block techniques are beneficial for improving the turnaround time. We share our experience of a rapid microwave cell‐block (MCB) technique.
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Correlation of p16 Immunostaining in Cell Blocks with Corresponding Tissue Specimens for Squamous Cell Carcinomas of the Oropharynx. Cytopathology (IF 1.493) Pub Date : 2020-09-04 Sharon J Song,Jalal B Jalaly
The goal of this study was to evaluate the performance of p16 staining in cell‐blocks vs tissue specimens as a surrogate marker for human papillomavirus (HPV) status in oropharyngeal squamous cell carcinomas.
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False-negative ultrasound-guided fine-needle aspiration of axillary lymph nodes in breast cancer patients. Cytopathology (IF 1.493) Pub Date : 2020-06-22 Naoko Iwamoto,Tomoyuki Aruga,Hidekazu Asami,Shin-Ichiro Horiguchi
The purpose of this study was to clarify the clinicopathological features of patients with false‐negative fine needle aspiration cytology (FNAC) and to determine the factors associated with negative FNAC.
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Persistent hydrocele fluid in a patient with transitional cell carcinoma. Cytopathology (IF 1.493) Pub Date : 2020-06-23 Helen Sarlanis,Konstantinos Stravodimos,Christos Papaioannou,Andreas Lazaris,Panagiota Mikou
This is a case of hydrocele fluid cytology, with very atypical cells, in a patient with a clinical history of urothelial carcinoma. The atypical cells were suspicious for malignancy and the differential diagnosis is discussed.
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Is micronucleus assay a suitable tumour marker in cervical carcinogenesis? Some concepts and paradigms. Cytopathology (IF 1.493) Pub Date : 2020-06-24 Daniel A Ribeiro
This letter discusses a previously published article in Cytopathology and provides comments the author believes allow better understanding regarding validating the micronucleus assay as a tumor marker in cervical carcinogenesis.
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Revisiting Cytomorphology, including Unusual Features and Clinical Scenarios of 8 Cases of Alveolar Soft Part Sarcoma with TFE3 Immunohistochemical Staining in Seven Cases. Cytopathology (IF 1.493) Pub Date : 2020-08-27 Bharat Rekhi,Vidya Rao,Mukta Ramadwar
To present a comprehensive analysis of cytomorphological features, including clinical scenarios, for 8 cases (4 males, 4 females, aged 17‐39 years, average = 28.5) of, retrospectively diagnosed alveolar soft part sarcoma (ASPS), with TFE3 immunostaining in 7 cases.
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Gastric-type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature. Cytopathology (IF 1.493) Pub Date : 2020-08-27 Nancy Y Greenland,Rebecca J Wolsky,Teresa M Darragh,Poonam Vohra
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Diagnosis of pancreatic solid pseudopapillary neoplasms using cell blocks and immunohistochemical evaluation of endoscopic ultrasound-guided fine-needle aspiration biopsy specimens. Cytopathology (IF 1.493) Pub Date : 2020-08-20 José Celso Ardengh,César Vivian Lopes,Filadélfio Euclides Venco,Marcel Autran Machado
Preoperative diagnostic imaging of pancreatic solid pseudopapillary neoplasms (SPNs) is challenging. A few studies have investigated the role of endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) for the diagnosis of SPN. We investigated the diagnostic yield of cell‐blocks and immunohistochemistry (IHC) for SPN using EUS‐FNA specimens without cytological evaluation.
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Multiple calvarial lesions in an adult male: Cytodiagnosis of a rare presentation. Cytopathology (IF 1.493) Pub Date : 2020-07-20 Shruti Gupta,Parikshaa Gupta,Saifullah Khalid,Ajay Kumar,Vivek Lal,Arvind Rajwanshi
Langerhans cell histiocytosis (LCH) is a clonal proliferative disorder of antigen‐presenting Langerhans’ cells, predominantly occurring in children with rare cases in adults. A definitive cytological diagnosis can be established on the basis of characteristic cytomorphology and immunocytochemical features.
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Cytological features and nuclear scores: diagnostic tools in preoperative fine-needle aspiration of indeterminate thyroid nodules with RAS or BRAF K601E mutations? Cytopathology (IF 1.493) Pub Date : 2020-08-16 Lucie Ravella,Jonathan Lopez,Françoise Descotes,Joris Giai,Véronique Lapras,Marie-Laure Denier,Françoise Borson-Chazot,Jean-Christophe Lifante,Myriam Decaussin-Petrucci
The cytological diagnosis of follicular‐patterned thyroid lesions is challenging, especially since the World Health Organisation classification has recognised non‐invasive follicular thyroid neoplasm with papillary‐like features. These entities are often classified as indeterminate on cytology. Molecular testing has been proposed to help classify indeterminate nodules. RAS and K601E BRAF mutations
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Cytomorphological features and literature review of CIC‐DUX4‐positive sarcoma, confirmed by reverse transcription polymerase chain reaction in a paediatric patient Cytopathology (IF 1.493) Pub Date : 2020-08-16 Bharat Rekhi; Priyanka Kembhavi; Surya Narayan Mishra
Certain undifferentiated round cell sarcomas characterised by specific underlying genetic fusions have been reported. This case describes cytomorphological and corresponding histopathological, including immunohistochemical features of a rare case of CIC‐DUX4 positive sarcoma, including a literature review of similar reported cases.
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Nuclear morphometry as an adjunct to cytopathologic examination of endometrial brushings on LBC samples: A prospective approach to combined evaluation in endometrial neoplasms and look alikes. Cytopathology (IF 1.493) Pub Date : 2020-08-13 Yoshiaki Norimatsu,Satoshi Irino,Yoshinobu Maeda,Kenji Yanoh,Tetsuji Kurokawa,Yasuo Hirai,Tadao K Kobayashi,Franco Fulciniti
In this study, we aimed to retrospectively investigate and confirm whether atypical nuclear findings in endometrial cytology are useful when assessed by image morphometry in liquid‐based cytology (LBC) and compared with microscopic evaluation.
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Metastatic breast cancer diagnosed on cervical cytology Cytopathology (IF 1.493) Pub Date : 2020-08-12 Lisi Yuan; Olaronke Oshilaja; Anne Sierk; Gloria Zhang; Christine N. Booth; Jennifer Brainard; Kathryn S. Dyhdalo
An unusual case is described of a 64‐year‐old woman with a remote history of breast cancer whose first non‐nodal metastasis was discovered on a routine Pap test. The Pap test was supported by the results of cervical and endometrial biopsies.
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Pancreatic space occupying lesion: 'Keep me in your mind'. Cytopathology (IF 1.493) Pub Date : 2020-08-07 Gargi Kapatia,Arvind Rajwanshi
This report describes a case of metastatic Ewing sarcoma in the pancreas of a young female diagnosed on FNAC with the help of immunocytochemistry.
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Cytology in the diagnosis of concomitant tuberculosis and leprosy by polymerase chain reaction using cytology scrapings. Cytopathology (IF 1.493) Pub Date : 2020-07-01 Ariba Zaidi,Parakriti Gupta,Parikshaa Gupta,Kusum Sharma,Tarun Narang,Arvind Rajwanshi
Tuberculosis and leprosy are endemic in developing countries of the world, despite major improvements in the general living conditions. Concomitant infection with tuberculosis and leprosy in the same individual are rarely seen in the modern era. We report co‐infection by tuberculosis in a known case of leprosy, diagnosed on cytology and confirmed by performing conventional polymerase chain reaction
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Gradually progressive increasing left thigh swelling in a young woman. Cytopathology (IF 1.493) Pub Date : 2020-08-04 Deepa Rani,Anurag Gupta,Pradyumn Singh
Synovial sarcoma is a malignant mesenchymal neoplasm of uncertain type with a specific translocation, t(X;18). Key cytological features and specific immunohistochemistry on cell block can help to establish a definite diagnosis.
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Expression of palladin is associated with disease progression in metastatic high-grade serous carcinoma. Cytopathology (IF 1.493) Pub Date : 2020-08-02 Ben Davidson,Annika Jøntvedt Bock,Arild Holth,Dag Andre Nymoen
To analyse the expression and clinical role of the actin‐associated molecule palladin in serous effusions.
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