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Conditioned Medium Treatment for the Improvement of Functional Recovery after Spinal Cord Injury: A Meta-Analysis Study Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-03-01 Razieh Hajisoltani, Mona Taghizadeh, Michael R Hamblin, Fatemeh Ramezani
Background:: While there is no certain treatment for spinal cord injury (SCI), stem cellbased therapy may be an attractive alternative, but the survival and differentiation of cells in the host tissue are poor. Conditioned medium (CM) has several beneficial effects on cells. Objective:: In this meta-analysis study, we examined the effect of CM on SCI treatment. Methods:: After searching on MEDLINE
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Efficacy and Mechanism of Highly Active Umbilical Cord Mesenchymal Stem Cells in the Treatment of Osteoporosis in Rats Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-15 Chuan Tian, Guanke Lv, Li Ye, Xiaojuan Zhao, Mengdie Chen, Qianqian Ye, Qiang Li, Jing Zhao, Xiangqing Zhu, Xinghua Pan
Background:: Osteoporosis increases bone brittleness and the risk of fracture. Umbilical cord mesenchymal stem cell (UCMSC) treatment is effective, but how to improve the biological activity and clinical efficacy of UCMSCs has not been determined. background: Osteoporosis increases bone brittleness and the risk of fracture. Umbilical cord mesenchymal stem cell (UCMSC) treatment is effective, but how
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Assessing the Impact of Stem Cell-based Therapy on Periodontal Health: A Meta-analysis of Clinical Studies Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-13 Yu-Han Shao, Yi Song, Qiao-Li Feng, Yan Deng, Tao Tang
Objective:: While clinical trials exploring stem cells for regenerating periodontal tissues have demonstrated positive results, there is a limited availability of systematic literature reviews on this subject. To gain a more comprehensive understanding of stem cell interventions in periodontal regeneration, this meta-analysis is undertaken to assess the beneficial effects of stem cells in human periodontal
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Regenerative Medicine and Nanotechnology approaches against Cardiovascular Diseases: Recent Advances and Future Prospective Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-12 Muhammad Waseem Sajjad, Fatima Muzamil, Maida Sabir, Usman Ali Ashfaq
: Regenerative medicine refers to medical research focusing on repairing, replacing, or regenerating damaged or diseased tissues or organs. Cardiovascular disease (CVDs) is a significant health issue globally and is the leading cause of death in many countries. According to the Centers for Disease Control and Prevention (CDC), one person dies every 34 seconds in the United States from cardiovascular
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Osteogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells on Composite Polymeric Scaffolds: A Review Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-05 Saeideh Hemati, Mohsen Ghiasi, Ali Salimi
: The mesenchymal stem cells (MSCs) are the fundamental part of bone tissue engineering for the emergence of reconstructive medicine. Bone tissue engineering has recently been considered a promising strategy for treating bone diseases and disorders. The technique needs a scaffold to provide an environment for cell attachment to maintain cell function and a rich source of stem cells combined with appropriate
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A Novel Multi-compartment Rotating Bioreactor for Improving ADSC--Spheroid Formation and its Application in Neurogenic Erectile Dysfunction Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-04 Peng Wang, Yang Liu, Xiao-Feng Duan, Xiao-Ying Pan, Xiang-Rui Kong, Yong Yang
Objective: The aim of this study was to construct a multicompartment synchronous rotating bioreactor (MCSRB) for batch-production of homogenized adipose-derived stem cell (ADSC) microspheres and treat neurogenic erectile dysfunction (ED). background: Erectile dysfunction due to cavernous nerve injury is commonly associated with pelvic site surgery1, particularly radical prostatectomy, which is one
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Bone Marrow Mesenchymal Stem Cell-derived Exosomal microRNA- 99b-5p Promotes Cell Growth of High Glucose-treated Human Umbilical Vein Endothelial Cells by Modulating THAP Domain Containing 2 Expression Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-04 Hongru Ruan, Hui Shi, Wenkang Luan, Sida Pan
Introduction: Bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) may function as novel candidates for treating diabetic wounds due to their ability to promote angiogenesis. Materials and Methods: This study investigated the effects of BMSC-exos on the growth and metastasis of human umbilical vein endothelial cells (HUVECs) treated with high glucose (HG). The exosomes were separated from
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Mechanisms of Stem Cells and Their Secreted Exosomes in the Treatment of Autoimmune Diseases Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-04 Shu-qian Lin, Kai Wang, Xing-hua Pan, Guang-ping Ruan
: Stem cells play a therapeutic role in many diseases by virtue of their strong self-renewal and differentiation abilities, especially in the treatment of autoimmune diseases. At present, the mechanism of the stem cell treatment of autoimmune diseases mainly relies on their immune regulation ability, regulating the number and function of auxiliary cells, anti-inflammatory factors and proinflammatory
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Evaluation of Pancreatic β-cell Differentiation Efficiency of Human iPSC Lines for Clinical Use Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-04 Ayumi Horikawa, Kyoko Tsuda, Takayoshi Yamamoto, Tatsuo Michiue
Background: Transplantation of pancreatic β-cells generated from human induced pluripotent stem cells (hiPSCs) has great potential as a root treatment for type 1 diabetes. However, their current level of efficiency to differentiate into β-cells is still not at par for clinical use. Previous research has shown that differentiation efficiency varies among human embryonic stem cells and mouse-induced
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Effect of Pioglitazone and Cetuximab on Colon Cancer Stem-like Cell (CCSLCs) Properties Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-02-02 Nasim Alamdar, Shirin Farivar, Kaveh Baghaei, Amir Ali Hamidieh, Hossein Soltaninejad, Hamid Asadzadeh Aghdaei, Mohammadreza Zali, Zohreh Saltanatpour
Background: One of the main reasons for cancer resistance to chemotherapy is the presence of cancer stem cells (CSCs) in cancer tissues. It is also believed that CSCs are the unique originators of all tumor cells. On the other hand, the Epithelial-Mesenchymal Transition pathway (EMT) can act as the main agent of metastasis. Therefore, it is possible that targeting CSCs as well as the EMT pathway could
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Nanoparticles’ Perspective in Skin Tissue Engineering: Current Concepts and Future Outlook Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-29 Maryam Kaviani, Bita Geramizadeh
: Nanotechnology seems to provide solutions to the unresolved complications in skin tissue engineering. According to the broad function of nanoparticles, this review article is intended to build a perspective for future success in skin tissue engineering. In the present review, recent studies were reviewed, and essential benefits and challenging issues regarding the application of nanoparticles in
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Distinctive Expression of Metastamirs in Breast Cancer Mesenchymal Stem Cells Isolated from Solid Tumor Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-24 Zahra Sadat Hashemi, Mehdi Forouzandeh Moghadam, Saeed Khalili, Seyed Mahmoud Hashemi, Koushan Sineh Sepehr, Esmaeil Sadroddiny
Background: MSCs are a part of the tumor microenvironment, which secrete cytokines and chemokines. They can affect metastasis and the growth of tumors. metastamiRs are newly recognized regulatory elements of the metastasis pathway which are involved in epithelial-to-mesenchymal transition (EMT). Objective: In the present study, we aimed to assess the expression profile of metastamiRs in the context
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Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-24 Jafar Poodineh, Azimeh Akhlaghpour, Farhoodeh Ghaedrahmati, Fatemeh Khojasteh Pour, Shahab Uddin, Maryam Farzaneh, Shirin Azizidoost
: Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted the critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis of the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal and differentiation capabilities, making them a potential therapeutic target for effective PCa treatment
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Enhancing Spermatogenesis in Non-obstructive Azoospermia through Mesenchymal Stem Cell Therapy Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-21 Ria Margiana
: Stem cells hold great promise as novel and encouraging therapeutic tools in the treatment of degenerative disorders due to their differentiation potential while maintaining the capability to self-renewal and their unlimited ability to divide and regenerate tissue. A variety of different types of stem cells can be used in cell therapy. Among these, mesenchymal stem cell (MSC) therapy has gradually
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Single-cell Technology in Stem Cell Research Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-21 Ali Golchin, Forough Shams, Faezeh Moradi, Amin Ebrahimi Sadrabadi, Shima Parviz, Shahriar Alipour, Parviz Ranjbarvan, Yaser Hemmati, Maryam Rahnama, Yousef Rasmi, Shiva Gholizadeh-Ghaleh Aziz
: Single-cell technology (SCT), which enables the examination of the fundamental units comprising biological organs, tissues, and cells, has emerged as a powerful tool, particularly in the field of biology, with a profound impact on stem cell research. This innovative technology opens new pathways for acquiring cell-specific data and gaining insights into the molecular pathways governing organ function
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Fucoxanthin Enhances the Antifibrotic Potential of Placenta-derived Mesenchymal Stem Cells in a CCl4-induced Mouse Model of Liver Fibrosis Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-11 Vasilii Slautin, Konstantin Konyshev, Ilya Gavrilov, Olga Beresneva, Irina Maklakova, Dmitry Grebnev
Background: The effectiveness of fucoxanthin (Fx) in liver diseases has been reported due to its anti-inflammatory and antifibrotic effects. Mesenchymal stem cells (MSCs)-based therapy has also been proposed as a promising strategy for liver fibrosis treatment. Recent studies have shown that the co-administration of MSCs and drugs demonstrates a pronounced effect on liver fibrosis. background: As a
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Bioinformatics-based Study on the Effects of Umbilical Cord Mesenchymal Stem Cells on the Aging Retina Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-11 Ya-Hui Shi, Jun-Qi Li, Min Xu, Yu-Ying Wang, Ting-Hua Wang, Zhong-Fu Zuo, Xue-Zheng Liu
Background: Retinal aging is one of the common public health problems caused by population aging and has become an important cause of acquired vision loss in adults. The aim of this study was to determine the role of human umbilical cord mesenchymal stem cells (hUCMSCs) in delaying retinal ganglion cell (RGC) aging and part of the network of molecular mechanisms involved. Methods: A retinal ganglion
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Enhancing the Regenerative Potential of Adipose-Derived Mesenchymal Stem Cells through TLR4-Mediated Signaling Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-11 Demet Kaçaroğlu, Seher Yaylacı
Introduction: Toll-like receptor 4(TLR4) is a receptor that traditionally plays an important role in immunomodulation (regulation of the immune system) and the initiation of proinflammatory responses. TLR4 is used in the body to recognize molecular patterns of pathogens or damaged cells from outside. However, in recent years, it has also become clear that TLR4 can affect the immune system and the function
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Human Adipose-derived Stem Cells Upregulate IGF-1 and Alleviate Osteoarthritis in a Two-stage Rabbit Osteoarthritis Model Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-09 Juan Wang, Shibo Su, Chuanming Dong, Qiang Fan, Jishu Sun, Siqing Liang, Zuhuo Qin, Chuqing Ma, Jianfeng Jin, Hongwen Zhu, Tongmeng Jiang, Jun Xu
Objective:: In recent times, it has been recognized that mesenchymal stem cells (MSCs) possess the capability to address osteoarthritis (OA). The objective of this research was to examine the impact of injecting human adipose-derived stem cells (hADSCs) into a novel rabbit osteoarthritis model with dual damage. Methods:: The OA model was established surgically first by medial collateral ligament and
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Mesenchymal Stem Cells Target Gastric Cancer and Deliver Epirubicin via Tunneling Nanotubes for Enhanced Chemotherapy Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-04 Yali Zhou, Yumin Li, Haibin Wang, Haolin Sun, Jing Su, Yaqiong Fan, Wei Xing, Jie Fu
Background:: A reduced effective local concentration significantly contributes to the unsatisfactory therapeutic results of epirubicin in gastric cancer. Mesenchymal stem cells exhibit targeted chemotaxis towards solid tumors and form tunneling nanotubes with tumor cells, facilitating the delivery of various substances. This study demonstrates the novelty of mesenchymal stem cells in releasing epirubicin
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Human Umbilical Cord Mesenchymal Stem Cells Alleviate Chronic Salpingitis by Modulating Macrophage-Associated Inflammatory Factors Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2024-01-04 Wenjuan Liao, Xiaomao Li, Xinrang Tang
Introduction:: Mesenchymal stem cells (MSCs) have been widely studied because of their established anti-inflammatory properties. During chronic salpingitis (CS), infiltrated macrophages have vital roles in inflammation and tissue remodeling. Methods:: We employed the type of MSCs, human umbilical cord (huc) MSCs in an experimental CS model and therapeutic efficacy was assessed. hucMSCs exerted this
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In-vitro Augmentation of Mesenchymal Stem Cells by Using Adult Bovine Serum Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-12-27 Somia Shehzadi, Maryam Javed, Asmat Ullah, Ahmad Bilal Waqar, Fatima Iftikhar Shah, Sajjad Ullah
Background:: Umbilical cord mesenchymal stem cells (UC-MSCs) are increasingly being utilized for immune-related disease therapies due to their low immunogenicity. However, the primary culture of UC-MSCs requires the supplementation of serum in the growth medium, which has posed a challenge due to ethical issues related to the collection method of the fetal bovine serum (FBS) that is routinely used
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Compression Promotes the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating METTL14-mediated IGF1 Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-12-01 Zengbo Wu
Background and Objectives:: Orthodontic treatment involves the application of mechanical force to induce periodontal tissue remodeling and ultimately promote tooth movement. It is essential to study the response mechanisms of human periodontal ligament stem cells (hPDLSCs) to improve orthodontic treatment. Methods:: In this study, hPDLSCs treated with compressive force were used to simulate orthodontic
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Regulation of ROS/inflammasome Axis is Essential for Cardiac Regeneration in Aging Rats Receiving Transplantation of Mesenchymal Stem Cells Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-11-30 Wei-Syun Hu, Jing-Yi Chen, Wei-Yu Liao, Chin-Hsien Chang, Tung-Sheng Chen
Background:: Aging is a biological and gradual deterioration of function in living organisms. Aging is one of the risk factors for heart disease. Objective:: Although mesenchymal stem cell transplantation shows potential in heart disease treatment, the relationship between stem cell-based therapy and oxidative stress/inflammasome axis regulation remains unclear. This study hypothesized that intervention
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Identifying Dental Pulp Stem Cell as A Novel Therapeutic Strategy for Digestive Diseases Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-11-29 Xieyin Sun, Zhaoyi Lin, Nuo Xu, Yinqi Chen, Saiyan Bian, Wenjie Zheng
: Mesenchymal stem cells (MSCs) have been identified as potential therapeutics for various diseases. In contrast to other sources of MSCs, dental stem cells (DSCs) have received increased attention due to their high activity and easy accessibility. Among them, dental pulp stem cells (DPSCs) exhibit superior self-renewal, multipotency, immunomodulatory, and regenerative capacities. Following their inspiring
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Meta-analysis of the Mesenchymal Stem Cells Immortalization Protocols: A Guideline for Regenerative Medicine Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-11-27 Priscila Elias Ferreira Stricker, Nathalia Barth de Oliveira, Bassam Felipe Mogharbel, Larissa Lührs, Ana Carolina Irioda, Eltyeb Abdelwahid, Luciane Regina Cavalli, Idiberto José Zotarelli-Filho, Katherine Athayde Teixeira de Carvalho
Background: This systematic review describes the most common methodologies for immortalizing human and animal mesenchymal stem cells (MSCs). This study follows the rules of PRISMA and is registered in the Institutional Review Board of PROSPERO International of systematic reviews, numbered protocol code: CRD42020202465. Method: The data search systematization was based on the words “mesenchymal stem
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The miR-210 Primed Endothelial Progenitor Cell Exosomes Alleviate Acute Ischemic Brain Injury Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-11-14 Jinju Wang, Shuzhen Chen, Harshal Sawant, Yanfang Chen, Ji Bihl
Background:: Stem cell-released exosomes (EXs) have shown beneficial effects on regenerative diseases. Our previous study has revealed that EXs of endothelial progenitor cells (EPC-EXs) can elicit favorable effects on endothelial function. EXs may vary greatly in size, composition, and cargo uptake rate depending on the origins and stimulus; notably, EXs are promising vehicles for delivering microRNAs
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Differentiation of Human Adipose-derived Stem Cells to Exosome-affected Neural-like Cells Extracted from Human Cerebrospinal Fluid Using Bioprinting Process Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-11-10 Mojtaba Cheravi, Javad Baharara, Parichehreh Yaghmaei, Nasim Hayati Roudbari
Background: Advancement in tissue engineering has provided novel solutions for creating scaffolds as well as applying induction factors in the differentiation of stem cells. The present research aimed to investigate the differentiation of human adipose-derived mesenchymal stem cells to neural-like cells using the novel bioprinting method, as well as the effect of cerebrospinal fluid exosomes. Methods:
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Different Sources of Bone Marrow Mesenchymal Stem Cells: A Comparison of Subchondral, Mandibular, and Tibia Bone-derived Mesenchymal Stem Cells Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-11-01 Yu Wang, Hong-Yu Li, Shu-Yuan Guan, Si-Han Yu, Yachuan Zhou, Li-Wei Zheng, Jun Zhang
Background: Stem cell properties vary considerably based on the source and tissue site of mesenchymal stem cells (MSCs). The mandibular condyle is a unique kind of craniofacial bone with a special structure and a relatively high remodeling rate. MSCs here may also be unique to address specific physical needs. Objective: The aim of this study was to compare the proliferation and multidirectional differentiation
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Transient Fever: the Sole Treatment-Related Adverse Event associated with Mesenchymal Stromal Cells and Solid Clues from the Real World Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-11-01 Yang Wang, Qiuying Mou, Hanxiao Yi, Zilu Meng
Background: The number of trials investigating mesenchymal stromal cells (MSCs) soars within 3 years which urges a study analysing emerging MSC treatment-related adverse events. Aim: To assess the safety of MSC therapy and provide solid evidence for clinical translation of MSC. Methods: A meta-analysis of randomized clinical trials (RCTs) published up to April 20th, 2023 was performed. Odds ratio (OR)
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Advances in Cell Transplantation Therapy for Limbal Stem Cell Deficiency Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-26 Yujia Gui, Yuxi He, Di Wang, Shurong Wang, Yan Zhang
Background: Limbal stem cells (LSCs) are essential for maintaining corneal transparency and ocular surface integrity. Many external factors or genetic diseases can lead to corneal limbal stem cell deficiency (LSCD), resulting in the loss of barrier and corneal epithelial cell renewal functions. Stem cell transplantation is one of the primary treatments for LSCD, including limbal transplantation and
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Comparative Efficacy of Endogenous Stem Cells Recruiting Hydrogels and Stem Cell-loaded Hydrogels in Knee Cartilage Regeneration: A Meta- analysis Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-18 Wanyun Feng, Chaohua Zhu, Ruoxiang Miao, Danni Li, Xi Xiong, Ruyu Wang, Guobin Liu, Jun Ma
Background: Cartilage defects remain a challenge in diseases such as osteoarthritis (OA) and fractures. Scientists have explored the use of hydrogels in conjunction with stem cell technology as a tissue engineering method to treat cartilage defects in joints. In recent years, research into hydrogels containing stem cell technology for cartilage repair has mainly focused on two categories: stem cell-loaded
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Insight to Biofabrication of Liver Microtissues for Disease Modeling: Challenges and Opportunities Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-17 Hengameh Dortaj, Negar Azarpira, Sara Pakbaz
: In the last decade, liver diseases with high mortality rates have become one of the most important health problems in the world. Organ transplantation is currently considered the most effective treatment for compensatory liver failure. An increasing number of patients and shortage of donors has led to the attention of reconstructive medicine methods researchers. The biggest challenge in the development
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Identification of Novel Stemness-based Subtypes and Construction of a Prognostic Risk Model for Patients with Lung Squamous Cell Carcinoma Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-16 Fangfang Shen, Feng Li, Yong Ma, Xia Song, Wei Guo
Background: Although cancer stem cells (CSCs) contribute to tumorigenesis, progression, and drug resistance, stemness-based classification and prognostic signatures of lung squamous cell carcinoma (LUSC) remain unclarified. This study attempted to identify stemness-based subtypes and develop a prognostic risk model for LUSC. Methods: Based on RNA-seq data from The Cancer Genome Atlas (TCGA), Gene-Expression
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Tumor Organoid as a Drug Screening Platform for Cancer Research Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-15 Reyhaneh Mahbubi, Niloufar Yousefi, Amir Ali Hamidieh, Fatemeh Gholizadeh, Mahsa Mollapour Sisakht
A number of studies have been conducted on the application of 3D models for drug discovery, drug sensitivity assessment, and drug toxicity. Most of these studies focused on disease modelling and attempted to control cellular differentiation, heterogeneity, and key physiological features to mimic organ reconstitution so that researchers could achieve an accurate response in drug evaluation. Recently
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RHBDD1 Promotes the Growth and Stemness Characteristics of Gastric Cancer Cells by Activating Wnt/β-catenin Signaling Pathway Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-13 Yingxue Yang, Yuan Yuan, Boning Xia
Backgrounds: Gastric cancer (GC) is threatening public health, with at least one million new cases reported each year. Rhomboid domain-containing protein 1 (RHBDD1) has been identified to regulate the proliferation, migration, and metastasis of cancer cells. However, the role of RHBDD1 in GC has not been elucidated. Objects: This study aimed to investigate the role of RHBDD1 on the growth, metastasis
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Progress of Cancer Stem Cells in Retinoblastoma Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-11 Nan Wang, Jian-Min Ma
: The theory of cancer stem cells is a breakthrough discovery that offers exciting possibilities for comprehending the biological behavior of tumors. More and more evidence suggests that retinoblastoma cancer stem cells promote tumor growth and are likely to be the origin of tumor formation, drug resistance, recurrence, and metastasis. At present, some progress has been made in the verification, biological
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The Effect of Mesenchymal Stem Cells on Wound Infection Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-11 Mansoor Khaledi, Bita Zandi, Zeinab Mohsenipour
:: Wound infection often requires a long period of care and an onerous treatment process. Also, the rich environment makes the wound an ideal niche for microbial growth. Stable structures, like biofilm, and drug-resistant strains cause a delay in the healing process, which has become one of the important challenges in wound treatment. Many studies have focused on alternative methods to deal the wound
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Mesenchymal Stem Cell Transplantation in Type 1 Diabetes Treatment: Current Advances and Future Opportunity Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-11 Jie Liu, Xin-Xing Wan, Sheng-Yuan Zheng, Hui-Hong He, Md. Asaduzzaman Khan, Yu-Xing Feng, Jing-Ge Xiao, Yu Chen, Xi-Min Hu, Qi Zhang, Kun Xiong
: Type 1 Diabetes (T1D) is characterized by hyperglycemia, and caused by a lack of insulin secretion. At present there is no cure for T1D and patients are dependent on exogenous insulin for lifelong, which seriously affects their lives. Mesenchymal stem cells (MSCs) can be differentiated to β cell-like cells to rescue the secretion of insulin and reconstruct immunotolerance to preserve the function
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Advancements in Biotechnology and Stem Cell Therapies for Breast Cancer Patients Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-11 Shivang Dhoundiyal, Prof.(Dr.) Md. Aftab Alam
: This comprehensive review article examines the integration of biotechnology and stem cell therapy in breast cancer diagnosis and treatment. It discusses the use of biotechnological tools such as liquid biopsies, genomic profiling, and imaging technologies for accurate diagnosis and monitoring of treatment response. Stem cell-based approaches, their role in modeling breast cancer progression, and
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Cancer Stem Cells and Treatment of Cancer: An Update and Future Perspectives Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-11 Mudassir Khan, Mashal Naeem, Sana Aftab Chaudary, Affan Ahmed, Aftab Ahmed
: Cancer stem cells (CSCs) play an essential role in tumour progression and metastasis. These cells have the unique ability to self-renew and differentiate into specific tissue cell types. Their capacity for self-renewal enables CSCs to persist over time, thereby contributing to cancer relapse and therapy resistance. Therefore, targeting CSCs has emerged as a promising cancer treatment strategy. CSCs
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Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19 Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-11 Elham Zendedel, Lobat Tayebi, Mohammad Nikbakht, Elham Hasanzadeh, Shiva Asadpour
: Mesenchymal Stem Cells (MSCs) are being investigated as a treatment for a novel viral disease owing to their immunomodulatory, anti-inflammatory, tissue repair and regeneration characteristics, however, the exact processes are unknown. MSC therapy was found to be effective in lowering immune system overactivation and increasing endogenous healing after SARS-CoV-2 infection by improving the pulmonary
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Therapeutic and Safety Promise of Mesenchymal Stem Cells for Liver Failure: from Preclinical Experiment to Clinical Application Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-09 Qiong Xie, Jundong Gu
:: Liver failure (LF) is serious liver damage caused by multiple factors, resulting in severe impairment or decompensation of liver synthesis, detoxification, metabolism, and biotransformation. The general prognosis of LF is poor with high mortality in non-transplant patients. The clinical treatments for LF are mainly internal medicine comprehensive care, an artificial liver support system, and liver
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Mesenchymal Stem Cell-conditioned Medium Protecting Renal Tubular Epithelial Cells by Inhibiting Hypoxia-inducible Factor-1α and Nuclear Receptor Coactivator-1 Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-09 Chunling Liao, Wenjuan Weng, Yiping Liu, Yongda Lin, Jiali Wang, Tianbiao Zhou
Background:: Acute kidney injury (AKI) is characterized by inflammatory infiltration and damage and death of renal tubular epithelial cells (RTECs), in which hypoxia plays an important role. Deferoxamine (DFO) is a well-accepted chemical hypoxia-mimetic agent. Mesenchymal stem cell-conditioned medium (MSC-CM) can reduce local inflammation and repair tissue. In this study, we explored the effect and
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Generating Retinas through Guided Pluripotent Stem Cell Differentiation and Direct Somatic Cell Reprogramming Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-09 Ke Zhang, Wenwen Cai, Leyi Hu, Shuyi Chen
: Retinal degeneration diseases affect millions of people worldwide but are among the most difficult eye diseases to cure. Studying the mechanisms and developing new therapies for these blinding diseases requires researchers to have access to many retinal cells. In recent years there has been substantial advances in the field of biotechnology in generating retinal cells and even tissues in vitro, either
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A Monocytic Barrier to the Humanization of Immunodeficient Mice Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-06 Emily J. Du, Marcus O. Muench
Mice with severe immunodeficiencies have become very important tools for studying foreign cells in an in vivo environment. Xenotransplants can be used to model cells from many species, although most often, mice are humanized through the transplantation of human cells or tissues to meet the needs of medical research. The development of immunodeficient mice is reviewed leading up to the current state-of-the-art
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Treatment with Exosomes Derived from Mesenchymal Stem Cells: A New Window of Healing Science in Regenerative Medicine Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-06 Arezoo Hormozi, Sajedeh Hasanzadeh, Faezeh Ebrahimi, Narges Daei, Zahra Hajimortezayi, Amir Mehdizadeh, Majid Zamani
Many studies have been conducted on the potential applications of mesenchymal stem cells (MSCs) over recent years due to their growing importance in regenerative medicine. Exosomes are considered cargos capable of transporting proteins, peptides, lipids, mRNAs, and growth factors. MSCsderived exosomes are also involved in the prevention or treatment of a variety of diseases, including cardiovascular
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Bone Marrow Mesenchymal Stem Cell Extracellular Vesicle-derived miR-27b- 3p activates the Wnt/Β-catenin Pathway by Targeting SMAD4 and Aggravates Hepatic Ischemia-reperfusion Injury Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-05 Hongnan Li, Weidong Lin, Yunlei Li, Jiayang Zhang, Runsheng Liu, Minghai Qu, Ruihua Wang, Xiaomin Kang, Xuekun Xing
Background: To investigate the roles of extracellular vesicles (EVs) secreted from bone marrow mesenchymal stem cells (BMSCs) and miR-27 (highly expressed in BMSC EVs) in hepatic ischemia‒ reperfusion injury (HIRI). Approaches and Results: We constructed a HIRI mouse model and pretreated it with an injection of agomir-miR-27-3p, agomir-NC, BMSC-EVs or control normal PBS into the abdominal cavity. Compared
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Adipose Stem Cells Derived Exosomes Alleviate Bronchopulmonary Dysplasia and Regulate Autophagy in Neonatal Rats Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-04 Yuanyuan Sun, Cuie Chen, Yuanyuan Liu, Anqun Sheng, Shi Wang, Xixi Zhang, Dan Wang, Qiu Wang, Chaosheng Lu, Zhenlang Lin
Background: Mesenchymal stem cell-derived exosomes (MSC-Exos) therapies have shown prospects in preclinical models of pathologies relevant to neonatal medicine, such as bronchopulmonary dysplasia (BPD). Adipose-derived stem cells (ADSCs) have been recognized as one of the most promising stem cell sources. Autophagy plays a key role in regulating intracellular conditions, maintaining cell growth and
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Impact of Mesenchymal Stem Cells on the Gut Microbiota and Microbiota Associated Functions in Inflammatory Bowel Disease: A Systematic Review of Preclinical Evidence on Animal Models Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-04 Airu Liu, Chenyang Li, Chen Wang, Xiaonan Liang, Xiaolan Zhang
Background: Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays a pivotal pathogenic role. Mesenchymal stem cells (MSCs) therapy has shown promising application prospects for its powerful immune regulation and tissue repair ability. Recent experimental data suggest that MSCs also regulate the composition of gut microbiota. The current review analyzed
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Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-10-02 Xiangyu Zhang, Xin Zhang, Lu Chen, Jiaqi Zhao, Ashok Raj, Yanping Wang, Shulin Li, Chi Zhang, Jing Yang, Dong Sun
Background: Angiogenesis and energy metabolism mediated by adipose mesenchymal stem cell-derived exosomes (AMSC-exos) are promising therapeutics for vascular diseases. Objectives: The current study aimed to explore whether AMSC-exos have therapeutic effects on oxygen and glucose deprivation (OGD) human umbilical vein endothelial cells (HUVECs) injury by modulating the SIX1/HBO1 signaling pathway to
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Co- and Triaxial Electrospinning for Stem Cell-based Bone Regeneration Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-20 Özlem Altundag, Mustafa Özgür Öteyaka, Betül Çelebi-Saltik
Bone tissue is composed of organic minerals and cells. It has the capacity to heal for certain minor damages, but when the bone defects surpass the critical threshold, they need fixing. Bone regeneration through natural and synthetic biodegradable materials requires various steps, such as manufacturing methods and materials selection. A successful biodegradable bone graft should have a high surface
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TNF-α Pretreated Hematopoietic Stem Cells Inhibit the Migration and Inflammatory Response of HUVECs and Attenuate GVHD Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-20 Jilei Sun, Tingting Zhou, Shiyuan Qin, Yaolei Zhang, Yong Yang, Zhitao Wei
Background: Hematologic diseases have seriously threatened human health. Although hematopoietic stem cell transplantation (HSCT) is an effective curative option, the complications, especially graft-versus-host disease (GVHD), are a big problem. Methods: TNF-α pretreatment of hematopoietic stem cells. Apoptosis was detected by flow cytometry, Transwell, and wound healing assays were used to assess cell
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Mesenchymal Stem Cell-Derived Exosomes Mitigate Acute Murine Liver Injury via Ets-1 and Heme Oxygenase-1 Up-regulation Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-19 Ying-Hsien Kao, Chih-Yang Chang, Yu-Chun Lin, Po-Han Chen, Po-Huang Lee, Huoy-Rou Chang, Wen-Yu Chang, Yo-Chen Chang, Shen-Fa Wun, Cheuk-Kwan Sun
Background: Mesenchymal stem cells (MSCs)-derived exosomes have been previously demonstrated to promote tissue regeneration in various animal disease models. This study investigated the protective effect of exosome treatment in carbon tetrachloride (CCl4)-induced acute liver injury and delineated possible underlying mechanism. Methods: Exosomes collected from conditioned media of previously characterized
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FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-19 Mengyao Zhao, Rong Rong, Chen Zhang, Haoqing Yang, Xiao Han, Zhipeng Fan, Ying Zheng, Jianpeng Zhang
Objectives: Periodontal ligament stem cells (PDLSCs) are ideal seed cells for periodontal tissue regeneration. Our previous studies have indicated that the histone methyltransferase PRDM9 plays an important role in human periodontal ligament stem cells (hPDLSCs). Whether FBLN5, which is a downstream gene of PRDM9, also has a potential impact on hPDLSCs is still unclear. Methods: Senescence was assessed
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Cancer Stem Cells in Carcinogenesis and Potential Role in Pancreatic Cancer Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-15 Rishav Sharma, Rishabha Malviya
: A poor prognosis is associated with pancreatic cancer because of resistance during treatment and early distant metastases. The discovery of cancer stem cells has opened up novel avenues for research into the biology and treatment of cancer. Many investigations have pointed out the role of these types of stem cells in the oncogenesis and progression of hematologic and solid malignancies, specifically
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Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-14 ling li, Siyu Hua, Lianghui You, Tianying Zhong
: Diabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment
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RADA-16-based Self-assembled Peptide Nanofiber Scaffolds Loaded with TGF-β1 Enhance the Chondrogenic Differentiation Potential of BMSCs In vitro Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-13 Peng Yu, Lian Duan, Zhen Yan, Jun Li, Dao-zhang Cai
Objective: At present, cartilage repair does not offer ideal efficacy. Fortunately, recent studies have claimed that RADA-16 peptide is an attractive therapeutic strategy for repairing cartilage defects. Therefore, this study tried to explore the effect of RADA-16 loaded with transforming growth factor-beta (TGF-β) 1 on cartilage differentiation of bone marrow mesenchymal stem cells (BMSCs). Methods:
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Evaluation of The Composite Skin Patch Loaded with Bioactive Functional Factors Derived from Multicellular Spheres of EMSCs for Regeneration of Full-thickness Skin Defects in Rats Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-11 Xuan Zhang, Wentao Shi, Xun Wang, Yin Zou, Wen Xiang, Naiyan Lu
Background: Transplantation of stem cells/scaffold is an efficient approach for treating tissue injury including full-thickness skin defects. However, the application of stem cells is limited by preservation issues, ethical restriction, low viability, and immune rejection in vivo. The mesenchymal stem cell conditioned medium is abundant in bioactive functional factors, making it a viable alternative
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Advancements in autologous stem cell transplantation for Parkinson’s Disease Curr. Stem Cell Res. Ther. (IF 2.7) Pub Date : 2023-09-11 Jia-Xin Shi, Ke-Zhong Zhang
: Parkinson's disease (PD) is a progressive neurodegenerative disease marked by comparatively focal dopaminergic neuron degeneration in the substantia nigra of the midbrain and dopamine loss in the striatum, which causes motor and non-motor symptoms. Currently, pharmacological therapy and deep brain stimulation(DBS) are the primary treatment modalities for PD in clinical practice. While these approaches