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Allogenic platelet-rich plasma for treating cartilage injury: A systematic review of the evidence on the basic sciences for potential future applications. Cells Tissues Organs (IF 2.7) Pub Date : 2023-11-09 Nur Hidayah Hassan,Raja Elina Ahmad,Tunku Kamarul,Pan Pan Chong
It is apparent that whilst many reports are available regarding Platelet-Rich-Plasma (PRP), the larger majority of these have been mainly focused on autologous sources, and for good reason. Issues relating to allogenic source have been consciously avoided owing to concerns of cross infectivity and immune rejection. However, this topic today is now revisited and is of interest since progress over the
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Potential Contribution of Cell Adhesion Molecule 1 to the Binding of SARS-CoV-2 Spike Protein to Mouse Nasal Mucosa. Cells Tissues Organs (IF 2.7) Pub Date : 2023-10-30 Fuka Takeuchi,Aki Sugano,Azusa Yoneshige,Man Hagiyama,Takao Inoue,Akihiro Wada,Yutaka Takaoka,Akihiko Ito
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first infects the host nasal mucosa, where the viral spike protein binds to angiotensin-converting enzyme 2 (ACE2) on the mucosal cells. This study aimed at searching host cell surface molecules that could contribute to the infection in two views; abundance on host cells and affinity to the spike protein. Since the nasal mucosa is lined by
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Three dimensional graphene promotes the proliferation of cholinergic neurons. Cells Tissues Organs (IF 2.7) Pub Date : 2023-10-09 Ziyun Jiang,Linhong Zhou,Miao Xiao,Sancheng Ma,Guosheng Cheng
BACKGROUND An early substantial loss of basal forebrain cholinergic neurons (BFCNs) is a common property of Alzheimer's disease and the degeneration of functional BFCNs is related to learning and memory deficits. As a biocompatible and conductive scaffold for growth of neural stem cells, three-dimensional graphene foam (3D-GF) supports applications in tissue engineering and regenerative medicine. Although
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Effects of cell-adhesive ligand presentation on pentapeptide supramolecular assembly and gelation: Simulations and Experiments. Cells Tissues Organs (IF 2.7) Pub Date : 2023-09-26 Andrew T Thede,James D Tang,Clare E Cocker,Liza J Harold,Connor D Amelung,Anna R Kittel,Phillip A Taylor,Kyle J Lampe
The extracellular matrix (ECM) is a complex, hierarchical material containing structural and bioactive components. This complexity makes decoupling the effects of biomechanical properties and cell-matrix interactions difficult, especially when studying cellular processes in a 3D environment. Matrix mechanics and cell adhesion are both known regulators of specific cellular processes such as stem cell
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Life of the B10 mouse: a view from the hair follicles and tissue stem cells. Cells Tissues Organs (IF 2.7) Pub Date : 2023-09-13 Kimihiko Sugaya
In our series of studies, the changes in the skin characteristics of mice caused by aging were investigated in correlation with the stem cells for keratinocytes and melanocytes in the natural hair cycle until middle age. The aim of the present review was to investigate these characteristics of hair follicles (HFs) at older age and complete the analysis of these changes as a study throughout the mouse
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Momordica charantia enhances tendon healing in rats: An experimental study. Cells Tissues Organs (IF 2.7) Pub Date : 2023-08-16 Furkan Erdoğan,Arife Ahsen Kaplan,Hüseyin Sina Coşkun,Gamze Altun,Berrin Zuhal Altunkaynak,Ebru Kelsaka,Suleyman Kaplan,Ahmet Pişkin
Momordica charantia (MC) is a traditional plant widely used since ancient times for wound healing. This study evaluated its potential effects on tendon healing. Adult Male Wistar albino rats (n=32, 8 rats in each group) were anesthetized, and their Achilles tendons were prepared for surgical procedures. Group 1 (Cont= control group) were not subjected to any surgery and were used as a control group
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Mild Synovitis Impairs Chondrogenic Joint Environment. Cells Tissues Organs (IF 2.7) Pub Date : 2023-07-31 Sharada Paudel,Tyler Feltham,Lumanti Manandhar,Yi Guo,Lew Schon,Zijun Zhang
The impact of mild synovitis on the chondrogenic environment in the joint pertaining to cartilage repair is often neglected. In this study, 21 synovial samples were collected from foot surgeries, for histology and isolation of fibroblast-like synoviocytes (FLS). Of the 21 samples, 13 were normal and eight mild synovitis according to their synovitis scores. In mild synovitis, CD3+lymphocytes were increased
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Protective Effect of Vaccinium myrtillus Extract on X-ray Irradiation-Induced Retinal Toxicity via eNOS and 8-OHdGexpression. Cells Tissues Organs (IF 2.7) Pub Date : 2023-07-28 Huseyin Findik,Mehmet Gökhan Aslan,Murat Okutucu,Adnan Yılmaz,Levent Tümkaya,Tolga Mercantepe,Kerimali Akyıldız,Feyzahan Uzun
Every year, hundreds of thousands of cancer patients receive radiotherapy treatment. Oxidative stress is observed in healthy tissues due to irradiation exposure. The present study is the first to address the effects of Vaccinium myrtillus (whortleberry, WB) against the effects of x-ray irradiation on retinal tissue. Twenty-four Sprague-Dawley rats were randomly allocated into 4 groups: (1) control
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The Effects of Dexmedetomidine on Abdominal Aortic Occlusion-Induced Ovarian Injury via Oxidative Stress and Apoptosis. Cells Tissues Organs (IF 2.7) Pub Date : 2023-06-20 Filiz Mercantepe,Levent Tumkaya,Tolga Mercantepe,Kerimali Akyildiz,Serpil Ciftel,Adnan Yilmaz
Ischemia/reperfusion (IR) induced ovarian damage is caused by various diseases such as ovarian torsion, ovarian transplantation, cardiovascular surgery, sepsis, or intra-abdominal surgery. I/R-related oxidative damage can impair ovarian functions, from oocyte maturation to fertilization. This study investigated the effects of Dexmedetomidine (DEX), which has been shown to exhibit antiapoptotic, anti-inflammatory
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Osteoclastogenesis requires primary cilia disassembly and can be inhibited by promoting primary cilia formation pharmacologically. Cells Tissues Organs (IF 2.7) Pub Date : 2023-05-22 Michael M Sutton,Michael P Duffy,Stefaan W Verbruggen,Christopher R Jacobs
The primary cilium is a solitary, sensory organelle with many roles in bone development, maintenance, and function. In the osteogenic cell lineage, including skeletal stem cells, osteoblasts and osteocytes, the primary cilium plays a vital role in the regulation of bone formation and this has made it a promising pharmaceutical target to maintain bone health. While the role of the primary cilium in
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Expression of Toll-Like Receptors in the Lung Tissue of Mouse Fetuses Generated by in vitro Embryo Culture and Embryo Transfer Cells Tissues Organs (IF 2.7) Pub Date : 2023-04-27 Göksel Doğan, Nedim Karagenç, Kerem Esmen, Bengi Çınar Kul, Hasan Yeşilkaya, Şakir Akgün, Mehmet Nurullah Orman, Mustafa Sandıkçı, Ülker Eren, Hümeyra Ünsal, Levent Karagenç
Mouse fetuses generated by in vitro embryo culture and embryo transfer exhibit impaired lung development, altered composition of pulmonary epithelial cells associated with downregulation of several genes involved in lung development and toll-like receptor (TLR) signaling pathway. The aims of the present study were to determine the expression of all TLRs and to examine if the expression of TLRs, along
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Developing Fibrous Biomaterials to Modulate Epithelial to Mesenchymal Transition Cells Tissues Organs (IF 2.7) Pub Date : 2023-04-18 Beth Blake, Tugba Ozdemir
Despite their critical roles in tissue repair and pathological processes such as fibrosis, tumor invasion and metastasis, the origins of mesenchymal cells remain poorly understood. Among the likely routes, epithelial to mesenchymal transitions (EMTs) emerge as important source of these cells. EMTs manifests themselves as a phenotypic transition in terminally differentiated epithelial cells into mesenchymal
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Emergence of Spatial Scales and Macroscopic Tissue Dynamics in Active Epithelial Monolayers Cells Tissues Organs (IF 2.7) Pub Date : 2023-04-12 Padmalochini Selvamani, Raghunath Chelakkot, Amitabha Nandi, Mandar M. Inamdar
Migrating cells in tissues are often known to exhibit collective swirling movements. In this paper, we develop an active vertex model with polarity dynamics based on contact inhibition of locomotion (CIL). We show that under this dynamics, the cells form steady-state vortices in velocity, polarity, and cell stress with length scales that depend on polarity alignment rate (ζ), self-motility (v0), and
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A Tunable Calcium Phosphate Coating to Drive in vivo Osseointegration of Composite Engineered Tissues Cells Tissues Organs (IF 2.7) Pub Date : 2023-03-24 Matthew Fainor, Sonal Mahindroo, Kerri R. Betz, Janai Augustin, Harvey E. Smith, Robert L. Mauck, Sarah E. Gullbrand
Varying degrees of hydroxyapatite (HA) surface functionalization have been implicated as the primary driver of differential osteogenesis observed in infiltrating cells. The ability to reliably create spatially controlled areas of mineralization in composite engineered tissues is of growing interest in the field, and the use of HA-functionalized biomaterials may provide a robust solution to this challenge
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Retraction Statement Cells Tissues Organs (IF 2.7) Pub Date : 2023-03-10 R.J. Gilbert, G. Sheng, C. Viebahn, H.-W. Denker, Arthur W. English, Molly Shoichet, Stephen Francis Badylak, Winfried L. Neuhuber, Anna M. Wobus, Anthony Ratcliffe, Loredana De Bartolo, Felix Eckstein, Adam J. Engler, Laura E. Niklason, Ursula Just, Donald F. Newgreen, Ryan J. Gilbert, George J. Christ, Erik Thompson, Heinrich Sauer, Paul J. Kingham, Michael Frotscher, Christoph Viebahn, Karen K.
Cells Tissues Organs
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Differentiation of myoblasts in culture: focus on serum and GABA Cells Tissues Organs (IF 2.7) Pub Date : 2023-03-03 Guzel Sibgatullina, Rahaf Al Ebrahim, Karina Gilizhdinova, Anna Tokmakova, Artem Malomouzh
There are many facts about the possible role of gamma-aminobutyric acid (GABA) in the development and differentiation of cells not only in nervous but also in muscle tissue. In the present study a primary culture of rat skeletal muscle myocytes was used to evaluate the correlation between the content of GABA in the cytoplasm and the processes of myocyte division and their fusion into myotubes.The effect
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Differentiation of myoblasts in culture: focus on serum and GABA Cells Tissues Organs (IF 2.7) Pub Date : 2023-03-03
There are many facts about the possible role of gamma-aminobutyric acid (GABA) in the development and differentiation of cells not only in nervous but also in muscle tissue. In the present study a primary culture of rat skeletal muscle myocytes was used to evaluate the correlation between the content of GABA in the cytoplasm and the processes of myocyte division and their fusion into myotubes.The effect
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Biographies of Contributors Cells Tissues Organs (IF 2.7) Pub Date : 2023-02-13 R.J. Gilbert, G. Sheng, C. Viebahn, H.-W. Denker, Arthur W. English, Molly Shoichet, Stephen Francis Badylak, Winfried L. Neuhuber, Anna M. Wobus, Anthony Ratcliffe, Loredana De Bartolo, Felix Eckstein, Adam J. Engler, Laura E. Niklason, Ursula Just, Donald F. Newgreen, Ryan J. Gilbert, George J. Christ, Erik Thompson, Heinrich Sauer, Paul J. Kingham, Michael Frotscher, Christoph Viebahn, Karen K.
Cells Tissues Organs
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Biographies of Contributors Cells Tissues Organs (IF 2.7) Pub Date : 2023-02-13
Cells Tissues Organs 2023;212:5–7
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Coupled mutual inhibition and mutual activation motifs as tools for cell-fate control Cells Tissues Organs (IF 2.7) Pub Date : 2023-02-09 Burhanuddin Sabuwala, Kishore Hari, Abhishek Shanmuga Vengatasalam, Mohit Kumar Jolly
Multistability is central to biological systems as it plays a crucial role in adaptation, evolvability, and differentiation. The presence of positive feedback loops can enable multistability. The simplest of such feedback loops are a) a mutual inhibition loop (MI), b) a mutual activation loop (MA), and c) self-activation, all three of them known to give rise to bistability. However, the characteristic
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Coupled mutual inhibition and mutual activation motifs as tools for cell-fate control Cells Tissues Organs (IF 2.7) Pub Date : 2023-02-09
Multistability is central to biological systems as it plays a crucial role in adaptation, evolvability, and differentiation. The presence of positive feedback loops can enable multistability. The simplest of such feedback loops are a) a mutual inhibition loop (MI), b) a mutual activation loop (MA), and c) self-activation, all three of them known to give rise to bistability. However, the characteristic
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Different effects of sugars and methods to preserve post-thaw functional properties of cryopreserved caprine spermatogonial stem cells Cells Tissues Organs (IF 2.7) Pub Date : 2023-02-02 Saleema Ahmedi Quadri, Shiva Pratap Singh, Suresh Dinkar Kharche, Juhi Pathak, Atul Saxena, Yogesh Kumar Soni, Dilip Swain
The present study aimed to identify the effects of sugar and methods [slow freezing (SF) vs fast freezing (FF)] on post-thaw in-vitro functional characteristics of cryopreserved caprine SSCs (cSSCs) and the cells obtained from cryopreserved testis tissue of pre-pubertal Barbari bucks. For this, in experiment-1, cSSCs were isolated and cryopreserved by either SF or FF method with different nonpermeable
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Different effects of sugars and methods to preserve post-thaw functional properties of cryopreserved caprine spermatogonial stem cells Cells Tissues Organs (IF 2.7) Pub Date : 2023-02-02
The present study aimed to identify the effects of sugar and methods [slow freezing (SF) vs fast freezing (FF)] on post-thaw in-vitro functional characteristics of cryopreserved caprine SSCs (cSSCs) and the cells obtained from cryopreserved testis tissue of pre-pubertal Barbari bucks. For this, in experiment-1, cSSCs were isolated and cryopreserved by either SF or FF method with different nonpermeable
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Give them vasculature and immune cells – how to fill the gap of organoids Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-30 Sophronia Yip, Nan Wang, Ryohichi Sugimura
Valid and relevant models are critical for research to have biological relevance or proceed in the right path. As well-established 2D cell cultures lack niches and cues and rodent models differ in species, 3D organoids emerged as a powerful platform for research. Cultured in vitro from stem cells, organoids are heterogeneous in cells and closely resemble the in vivo settings. Organoids also recapitulate
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Give them vasculature and immune cells – how to fill the gap of organoids Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-30
Valid and relevant models are critical for research to have biological relevance or proceed in the right path. As well-established 2D cell cultures lack niches and cues and rodent models differ in species, 3D organoids emerged as a powerful platform for research. Cultured in vitro from stem cells, organoids are heterogeneous in cells and closely resemble the in vivo settings. Organoids also recapitulate
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Acknowledgement to Referees Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-04
Cells Tissues Organs 2022;211:755
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Contents Vol. 211, 2022 Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-04
Cells Tissues Organs 2022;211:I–VI
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Using optogenetics to investigate the shared mechanisms of apical-basal polarity and mitosis Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-04 Helena A. Crellin, Clare E. Buckley
The initiation of apical-basal (AB) polarity and the process of mitotic cell division are both characterised by the generation of specialised plasma membrane and cortical domains. These are generated using shared mechanisms, such as asymmetric protein accumulation, Rho GTPase signalling, cytoskeletal reorganisation, vesicle trafficking and asymmetric phosphoinositide distribution. In epithelial tissue
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Adoptive Immunotherapy: A Human Pluripotent Stem Cell Perspective Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-04
The past decade has witnessed significant advances in cancer immunotherapy, particularly through the adoptive transfer of engineered T cells in treating advanced leukemias and lymphomas. Despite these excitements, challenges remain with scale, cost, and ensuring quality control of engineered immune cells, including chimeric antigen receptor (CAR) T, natural killer (NK) cells, and macrophages. The advent
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Glycoconjugate-specific developmental changes in the horse vomeronasal organ Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-04 Jiyoon Chun, Taeyoung Kang, Jong-Pil Seo, Hyohoon Jeong, Minhan Kim, Byung Sun Kim, Meejung Ahn, Jeongtae Kim, Taekyun Shin
Vomeronasal organ (VNO) is a tubular pheromone sensing organ in which the lumen is covered with sensory and non-sensory epithelia. This study used immunohistochemistry and lectin histochemistry techniques to evaluate developmental changes, specifically of the glycoconjugate profile, in the horse VNO epithelium. Immunostaining analysis revealed PGP9.5 expression in some vomeronasal non-sensory epithelium
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Adoptive Immunotherapy: A Human Pluripotent Stem Cell Perspective Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-04
The past decade has witnessed significant advances in cancer immunotherapy, particularly through the adoptive transfer of engineered T cells in treating advanced leukemias and lymphomas. Despite these excitements, challenges remain with scale, cost, and ensuring quality control of engineered immune cells, including chimeric antigen receptor (CAR) T, natural killer (NK) cells, and macrophages. The advent
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Glycoconjugate-specific developmental changes in the horse vomeronasal organ Cells Tissues Organs (IF 2.7) Pub Date : 2023-01-04
Vomeronasal organ (VNO) is a tubular pheromone sensing organ in which the lumen is covered with sensory and non-sensory epithelia. This study used immunohistochemistry and lectin histochemistry techniques to evaluate developmental changes, specifically of the glycoconjugate profile, in the horse VNO epithelium. Immunostaining analysis revealed PGP9.5 expression in some vomeronasal non-sensory epithelium
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Nuclear biophysical changes during human melanoma plasticity Cells Tissues Organs (IF 2.7) Pub Date : 2022-12-12 Maria Chiara Lionetti, Maria Rita Fumagalli, Caterina A.M. La Porta
Tumor plasticity is an emerging property of tumor cells which allows them to change their phenotype in dependence on the environment. The epithelial-mesenchymal transition plays a crucial role in helping cells to acquire a more aggressive phenotype when they are in the mesenchymal state. Herein we investigated the biophysical changes occurring during phenotypic switching in human melanoma cells considering
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Prediction of Golgi Polarity in Collectively Migrating Epithelial Cells Using Graph Neural Network Cells Tissues Organs (IF 2.7) Pub Date : 2022-12-01 Purnati Khuntia, Tamal Das
In the stationary epithelium, the Golgi apparatus assumes an apical position, above the cell nucleus. However, during wound healing and morphogenesis, as the epithelial cells starts migrating, it relocalizes closer to the basal plane. On this plane, the position of Golgi with respect to the cell nucleus defines the organizational polarity of a migrating epithelial cell, which is crucial for an efficient
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Protocol-dependent morphological changes in human embryonic stem cell aggregates during differentiation towards early pancreatic fate Cells Tissues Organs (IF 2.7) Pub Date : 2022-11-14 Elmira Rezaei Zonooz, Zahra Ghezelayagh, Azadeh Moradmand, Hossein Baharvand, Yaser Tahamtani
Cell therapy is one of the promising approaches used against type1 diabetes. Efficient generation of Human embryonic stem cell (hESC)-derived pancreatic progenitors (PPs) is of great importance. Since signaling pathways underlying human pancreas development is not yet fully understood, various differentiation protocols are conducted each considering variable duration, timing and concentrations of growth
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On the variability in cell and nucleus shape Cells Tissues Organs (IF 2.7) Pub Date : 2022-10-31 Anusha Devulapally, Varun Parekh, Clint Pazhayidam George, Sreenath Balakrishnan
Cell morphology is an important regulator of cell function. Many abnormalities in cellular behavior can be discerned from changes in the shape of the cell and its organelles, typically the nucleus. Two major challenges for developing such phenotypic assays are reconstructing 3D surfaces of individual cells and nuclei from confocal images and developing characterizations of these surfaces for comparisons
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MicroRNA-133a-3p inhibits lung adenocarcinoma development and cisplatin resistance through targeting GINS4 Cells Tissues Organs (IF 2.7) Pub Date : 2022-10-21 Yafu Zhou, Jianhua Yan, Huiguo Chen, Wenwu Zhou, Jinsong Yang
GINS subunit complex 4 (GINS4) is fundamental to DNA replication and G1/S phase transition of the cell cycle in eukaryotes. Further, recent studies implied that GINS4 can mediate the progression of several tumors, but its mechanism in lung adenocarcinoma (LUAD) is not clarified. Therefore, the role of GINS4 in LUAD was explored. MiR-133a-3p and GINS4 mRNA expression were tested through qRT-PCR. Protein
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Umbilical cord blood cell clearance post-infusion in immune competent children with cerebral palsy Cells Tissues Organs (IF 2.7) Pub Date : 2022-10-19 Kylie Crompton, David E Godler, Ling Ling, Ngaire Elwood, Francoise Mechinaud-Heloury, Trisha Soosay Raj, Kuang-Chih Hsiao, Jacqueline Fleming, Karin Tiedemann, Iona Novak, Michael C. Fahey, Xiaofang Wang, Katherine J Lee, Paul B. Colditz, Priya Edwards, Dinah Reddihough
Umbilical cord blood cells have therapeutic potential for neurological disorders, through a paracrine mechanism of action. A greater understanding of the safety and immunological effects of allogeneic donor cord blood cells in the context of a healthy recipient immune system, such as in cerebral palsy, is needed. This study aimed to determine how quickly donor cord blood cells were cleared from the
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Assessing combinatorial diversity of aureochrome bZIPs through genome-wide screening Cells Tissues Organs (IF 2.7) Pub Date : 2022-10-19 Madhurima Khamaru, Deep Nath, Devrani Mitra, Soumen Roy
Aureochromes are unique blue light-responsive LOV (Light Oxygen Voltage) photoreceptors cum basic leucine zipper (bZIP) transcription factors (TFs), present exclusively in photosynthetic marine stramenopiles. Considering the availability of the complete genome sequence, this study focuses on aureochromes from Ectocarpus siliculosus. Aureochromes mediate light-regulated developmental responses in this
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Hepatocyte Growth Factor Promotes Differentiation Potential and Stress Response of Human Stem Cells from Apical Papilla Cells Tissues Organs (IF 2.7) Pub Date : 2022-09-28 Zhenhai Liu, Na Yan, Ying Chen, Bin Hu
Harsh local microenvironment, such as hypoxia and lack of instructive clues for transplanted stem cells, presents the serious obstacle for stem cell therapies’ efficacy. Therefore, continued efforts have been taken to improve stem cells’ viability and plasticity. Hepatocyte growth factor (HGF) have previously been reported to mitigate complications of various human diseases in animal model studies
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Organoids in the clinic: a systematic review of outcomes Cells Tissues Organs (IF 2.7) Pub Date : 2022-09-28 Bjørn Hofmann, Severin Zinöcker, Søren Holm, Jonathan Lewis, Panagiotis Kavouras
Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature
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Altered expression of pulmonary epithelial cell markers in fetal and adult mice generated by in vitro embryo culture and embryo transfer Cells Tissues Organs (IF 2.7) Pub Date : 2022-09-14 Göksel DOĞAN, Murat Öztürk, Didar Tuğçe Karakulak, Levent Karagenç
Lung development is impaired in mice generated through transfer of in vitro-derived blastocysts. The main objective of the current study was to determine if the composition of epithelial cells in the fetal and adult lung tissue is altered in mice generated through transfer of in vitro-derived blastocysts. The study comprised of two experimental (EGs) and two control (CGs) groups. Fetuses (18.5 d.p
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Artificial microvesicles: new perspective on healing tendon wounds Cells Tissues Organs (IF 2.7) Pub Date : 2022-09-01 Elena Zakirova, Alexander Aimaletdinov, Milana Mansurova, Angelina Titova, Igor Kurilov, Catrin Sian Rutland, Albina Malanyeva, Albert Rizvanov
Tendons have a limited capacity to repair both naturally and following clinical interventions. Damaged tissue often presents with structural and functional differences, adversely affecting animal performance, mobility, health and welfare. Advances in cell therapies have started to overcome some of these issues, however complications such as the formation of ectopic bone remain a complication of this
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Apoptosis-Decellularized Peripheral Nerve Scaffold Allows Regeneration across Nerve Gap Cells Tissues Organs (IF 2.7) Pub Date : 2022-08-26 Rebecca A. Wachs, Steven M. Wellman, Stacy L. Porvasnik, Emily H. Lakes, R. Chase Cornelison, Young Hye Song, Kyle D. Allen, Christine E. Schmidt
Peripheral nerve injury results in loss of motor and sensory function distal to the nerve injury and is often permanent in nerve gaps longer than 5 cm. Autologous nerve grafts (nerve autografts) utilize patients’ own nerve tissue from another part of their body to repair the defect and are the gold standard in care. However, there is a limited autologous tissue supply, size mismatch between donor nerve
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Molecular characterization and differentiation of mesenchymal progenitor cells from human rheumatoid arthritis cartilage Cells Tissues Organs (IF 2.7) Pub Date : 2022-08-26 Akshay Bairapura Manjappa, Siddharth Shetty, Santhosh Babu, Reshma Shetty, Shantharam Shetty, Ananthram Shetty, Basavarajappa Mohana Kumar
The presence of mesenchymal progenitor cells (MPCs) in rheumatoid arthritis (RA) articular cartilage is sparsely investigated largely owing to the persistent pathogenic disease condition and lack of specific biomarkers. Considering the recent advancements for potential cell-based therapies in immunomodulatory diseases, such as RA, this in vitro study was aimed at investigating the cellular, molecular
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A Multistep Tumor Growth Model of High Grade Serous Ovarian Carcinoma Identifies Hypoxia Associated Signatures Cells Tissues Organs (IF 2.7) Pub Date : 2022-08-15 Madhuri H. More, Sagar S. Varankar, Rutika R. Naik, Rahul D. Dhake, Pritha Ray, Rahul M. Bankar, Avinash M. Mali, Ayalur Raghu Subbalakshmi, Priyanka Chakraborty, Mohit Kumar Jolly, Sharmila A. Bapat
High-grade serous ovarian carcinoma (HGSC) is associated with late-stage disease presentation and poor prognosis, with limited understanding of early transformation events. Our study presents a comprehensive analysis of tumor progression and organ-specific metastatic dissemination to identify hypoxia-associated molecular, cellular, and histological alterations during HGSC tumor growth. HE staining
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Effect of Cell Derived Matrices on growth and differentiation of human Wharton’s jelly derived Mesenchymal Stem Cells Cells Tissues Organs (IF 2.7) Pub Date : 2022-07-29 Sakthivel Selvaraj, Secunda Rupert, Sangeetha Kadapakkam Nandabalan, Charumathi Anbalagan, Prasanna Srinivasan Rajaram, Jeswanth Satyanesan, Rosy Vennila, Surendran Rajagopal
Cell derived matrices (CDMs) are scaffolds constructed by decellularization of cellular matrices from different tissues and organs. Since cell derived matrices mimic the ECM of native tissues, CDM plays an essential role in the preparation of bioscaffolds. CDM scaffolds from Mesenchymal Stem Cells (MSCs) have been reported to support cell adhesion and proliferation of its own cells. Therefore, in this
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Aneuploidy rate and Stemness in Low-level Mosaic Human Embryonic Stem Cells in the Presence/Absence of Bortezomib, Paclitaxel and Lapatinib Cells Tissues Organs (IF 2.7) Pub Date : 2022-07-28 Nazanin Sadat Khademi, Shirin Farivar, Masood Bazrgar, Seyedeh-Nafiseh Hassani, Najmeh Sadat Masoudi, Newsha Haghparast, Mehran Rezaei Larijani
Human embryonic stem cells (hESCs) are predisposed to aneuploidy through continual passages. Some reports indicate more sensitivity of aneuploid hESCs cells to anticancer drugs. The present study was designed to investigate the cytotoxicity of three anticancer drugs (including bortezomib, paclitaxel and lapatinib) and their effect on aneuploidy rate in hESCs. To create a low-level mosaic cell line
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Mesenchymal stromal cell-secretome for therapeutic application in skin wound healing: a systematic review of preclinical studies Cells Tissues Organs (IF 2.7) Pub Date : 2022-07-22 Maiara Marques da Silva, Débora Cristina Olsson, Bianca Luise Teixeira, Talita da Silva Jeremias, Andrea Gonçalves Trentin
Non-healing skin wounds remain a challenge in the healthcare system. In this sense, it is suggested that the secretome of mesenchymal stromal cells (MSCs) can be effective as a therapeutic strategy for regenerative medicine. Therefore, this systematic review aimed to determine the effects of treatment with secretome derived from MSCs on the healing of skin wounds in preclinical model of rodents (mice
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Strategies and challenges in the treatment of dental enamel Cells Tissues Organs (IF 2.7) Pub Date : 2022-07-01 Elaheh Dalir Abdolahinia, Sadaf Ilbeygi Taher, Parnaz Abdali Dehdezi, Atefe Ataei, Majid Azizi, Narges Afra, Samira Afshar Fard, Simin Sharifi
Enamel tissue, the hardest body tissue, which covers the outside of the tooth shields the living tissue, but it erodes and disintegrates in the acidic environment of the oral cavity. On the one hand, mature enamel is cell-free and, if damaged, does not regenerate. Tooth sensitivity and decay are caused by enamel loss. On the other hand, the tissue engineering approach is challenging because of the
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Circ_0062582 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro by elevating SMAD5 expression through sponging miR-197-3p Cells Tissues Organs (IF 2.7) Pub Date : 2022-06-28 Qiaojie Chen, Pingping Shen, Bo Zhang, Yang Chen, Chunli Zheng
Circular RNAs (circRNAs) play crucial roles in many human diseases. However, the functions of circRNAs in osteoporosis (OP) are barely reported. In this study, we aimed to explore the function of circ_0062582 in osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) in vitro. Circ_0062582 and SMAD5 were downregulated and miR-197-3p was upregulated in OP patients and increased
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