当前期刊: Trends in Cell Biology Go to current issue    加入关注    本刊投稿指南
显示样式:        排序: IF: - GO 导出
  • Lipid Droplet Nucleation
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-12-05
    Abdou Rachid Thiam; Elina Ikonen

    All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets, surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid metabolism and function in diverse biological processes. During the past decade, multidisciplinary approaches have shed light on LD assembly steps from the endoplasmic reticulum (ER): nucleation, growth, budding, and formation

  • Programmed Cell Death: Central Player in Fungal Infections
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-12-05
    Giorgio Camilli; Mariana Blagojevic; Julian R. Naglik; Jonathan P. Richardson

    Fungal diseases contribute significantly to morbidity and mortality in humans. Although recent research has improved our understanding of the complex and dynamic interplay that occurs between pathogenic fungi and the human host, much remains to be elucidated concerning the molecular mechanisms that drive fungal pathogenicity and host responses to fungal infections. In recent times, there has been a

  • Cell Migration Guided by Cell–Cell Contacts in Innate Immunity
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-12-03
    Veronika Miskolci; Lucas C. Klemm; Anna Huttenlocher

    The directed migration of leukocytes to sites of damage or infection is necessary for a productive immune response. There is substantial evidence supporting a key role for chemoattractants in directed migration, however, less is known about how cell–cell contacts affect the migratory behavior of leukocytes in innate immunity. Here, we explore how cell–cell contacts can affect the directed migration

  • Fukutin-Related Protein: From Pathology to Treatments
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-12-01
    Carolina Ortiz-Cordero; Karim Azzag; Rita C.R. Perlingeiro

    Fukutin-related protein (FKRP) is a glycosyltransferase involved in the functional glycosylation of α-dystroglycan (DG), a key component in the link between the cytoskeleton and the extracellular matrix (ECM). Mutations in FKRP lead to dystroglycanopathies with broad severity, including limb-girdle and congenital muscular dystrophy. Studies over the past 5 years have elucidated the function of FKRP

  • CDK1, the Other ‘Master Regulator’ of Autophagy
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-11-30
    Richard I. Odle; Oliver Florey; Nicholas T. Ktistakis; Simon J. Cook

    Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant controversy; for example, studies have argued that autophagy is either repressed or

  • Dynamic Plasma Membrane Organization: A Complex Symphony
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-11-25
    Sjoerd van Deventer; Abbey B. Arp; Annemiek B. van Spriel

    Membrane protein organization is essential for proper cellular functioning and the result of a dynamic exchange between protein monomers, nanoscale protein clusters, and microscale higher-order structures. This exchange is affected by both lipid bilayer intrinsic factors, such as lipid rafts and tetraspanins, and extrinsic factors, such as cortical actin and galectins. Because membrane organizers act

  • Caspase 2 and p53 Reunited in Tumor Control.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-11
    Giulia Petroni,Ilio Vitale,Lorenzo Galluzzi

    Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.

  • Cellular Senescence Variation by Metabolic and Epigenomic Remodeling.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-23
    Mitsuyoshi Nakao,Hiroshi Tanaka,Tomoaki Koga

    Cellular senescence is a state of permanent cell cycle arrest accompanied by unique secretory actions, which influences tissue formation, tumor suppression and aging in vivo. Recent evidences suggest that metabolic and epigenomic reprogram cooperatively creates phenotypic differences of senescent cells, which may provide new clues to control aging processes.

  • Cristae Membrane Dynamics - A Paradigm Change.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-23
    Arun Kumar Kondadi,Ruchika Anand,Andreas S Reichert

    Mitochondria are dynamic organelles that have essential metabolic and regulatory functions. Earlier studies using electron microscopy (EM) revealed an immense diversity in the architecture of cristae – infoldings of the mitochondrial inner membrane (IM) – in different cells, tissues, bioenergetic and metabolic conditions, and during apoptosis. However, cristae were considered to be largely static entities

  • Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-23
    Radiana Ferrero; Pernille Rainer; Bart Deplancke

    White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as an energy reservoir, but also actively participates in metabolic homeostasis. Among the main constituents of adipose tissue are adipocytes, which arise from adipose stem and progenitor cells (ASPCs). While it is well known that these ASPCs reside in the stromal vascular fraction (SVF) of adipose tissue

  • Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-24
    Felix J B Bäuerlein,Rubén Fernández-Busnadiego,Wolfgang Baumeister

    Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are still lacking. Therefore, therapeutic strategies are limited to symptomatic treatments. A common histopathological hallmark of many neurodegenerative diseases is the presence of large

  • Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-11-04
    Esha Madan; Maria Leonor Peixoto; Peter Dimitrion; Timothy D. Eubank; Michail Yekelchyk; Sarmistha Talukdar; Paul B. Fisher; Qing-Sheng Mi; Eduardo Moreno; Rajan Gogna

    The comparison of fitness between cells leads to the elimination of less competent cells in the presence of more competent neighbors via cell competition (CC). This phenomenon has been linked with several cancer-related genes and thus may play an important role in cancer. Various processes are involved in the regulation of tumor initiation and growth, including tumor hypoxia, clonal stem cell selection

  • Lipid Metabolism in Regulation of Macrophage Functions
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-06
    Jiawei Yan; Tiffany Horng

    Macrophages are cells of the innate immune system that regulate the maintenance of tissue homeostasis, host defense during pathogen infection, and tissue repair in response to tissue injury. Recent studies indicate that macrophage functions are influenced by cellular metabolism, including lipid metabolism. Here, we review how macrophage lipid metabolism can be dynamically altered in different physiological

  • Extracellular Vesicle-Associated Proteins in Tissue Repair
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-14
    Marieke T. Roefs; Joost P.G. Sluijter; Pieter Vader

    The administration of (stem) cell-derived extracellular vesicles (EVs) promotes tissue repair through management of different inflammatory, proliferative and remodeling processes in the body. Despite the widely observed biological and therapeutic roles of EVs in wound healing and tissue repair, knowledge on how EVs activate recipient cells and which EV cargo is responsible for the subsequent functional

  • Chromatin Tracing: Imaging 3D Genome and Nucleome
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-11-12
    Mengwei Hu; Siyuan Wang

    Correct 3D genome organization is essential for the proper functioning of the genome. Recent advances in image-based 3D genomics techniques have enabled direct tracing of chromatin folding and multiplexed imaging of nucleome architectures in single cells of several important biological systems. Here, we discuss these advances and the future directions of image-based 3D genomics.

  • Global miRNA to miRNA Interactions: Impacts for miR-21
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-11-11
    Meredith Hill; Nham Tran

    miRNAs inherently alter the cellular environment by regulating target genes. miRNAs may also regulate other miRNAs, with far-reaching influence on miRNA and mRNA expression. We explore this realm of small RNA regulation with a focus on the role of the oncogenic miR-21 and its impact on other miRNA species.

  • Cutting, Amplifying, and Aligning Microtubules with Severing Enzymes
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-11-09
    Yin-Wei Kuo; Jonathon Howard

    Microtubule-severing enzymes – katanin, spastin, fidgetin – are related AAA-ATPases that cut microtubules into shorter filaments. These proteins, also called severases, are involved in a wide range of cellular processes including cell division, neuronal development, and tissue morphogenesis. Paradoxically, severases can amplify the microtubule cytoskeleton and not just destroy it. Recent work on spastin

  • Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-10
    Ayako Nakamura-Ishizu,Shah Adil Ishtiyaq Ahmad,Toshio Suda

    The transplantation of healthy hematopoietic stem cells (HSCs) contained in the bone marrow is a frontline treatment option for hematopoietic diseases. Detailed analysis of post-transplant HSC kinetics is crucial as the initial engraftment of HSCs influences prognosis. Dong et al. have explored the dynamic change in HSC cell fate upon bone marrow transplantation through the utilization of single-cell

  • All Roads Lead to Directional Cell Migration.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-08-29
    Adam Shellard,Roberto Mayor

    Directional cell migration normally relies on a variety of external signals, such as chemical, mechanical, or electrical, which instruct cells in which direction to move. Many of the major molecular and physical effects derived from these cues are now understood, leading to questions about whether directional cell migration is alike or distinct under these different signals, and how cells might be

  • Histone Variants and Histone Modifications in Neurogenesis
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-30
    Mengtian Zhang; Jinyue Zhao; Yuqing Lv; Wenwen Wang; Chao Feng; Wenzheng Zou; Libo Su; Jianwei Jiao

    During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS) development. Here, we provide a broad overview of the

  • When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-06
    Matías González-Quiroz; Alice Blondel; Alfredo Sagredo; Claudio Hetz; Eric Chevet; Rémy Pedeux

    Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies

  • Cardiolipin in Immune Signaling and Cell Death
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-30
    Malvina Pizzuto; Pablo Pelegrin

    Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions, CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM). Dead signals, infection, or disease may change the level of CL saturation and oxidation and cause its translocation to the cytosolic side of the outer mitochondrial membrane (OMM), affecting mitochondrial function and

  • Photoreceptor Discs: Built Like Ectosomes.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-06
    William J Spencer,Tylor R Lewis,Jillian N Pearring,Vadim Y Arshavsky

    The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened ‘disc’ membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential for photoreceptor viability. In this review, we describe recent breakthroughs in the

  • The Endothelium: An Active Regulator of Lipid and Glucose Homeostasis
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-28
    Sana S. Hasan; Andreas Fischer

    The vascular endothelium serves as a dynamic barrier that separates blood from interstitia. Endothelial cells (ECs) respond rapidly to changes in the circulation and actively regulate vessel tone, permeability, and platelet functions. ECs also secrete angiocrine factors that dictate the function of adjacent parenchymal cells in an organ-specific manner. Endothelial dysfunction is considered as a hallmark

  • Protein Sorting within Chloroplasts
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-26
    Xiumei Xu; Min Ouyang; Dandan Lu; Canhui Zheng; Lixin Zhang

    Chloroplasts have multiple suborganellar membranes. Correct and efficient translocation of chloroplast proteins from their site of synthesis into or across membranes to their functional compartments are fundamental processes. In recent years, several new components and regulatory mechanisms involved in chloroplast protein import and sorting have been explored. Moreover, the formation of liquid–liquid

  • Mitochondrial Fusion: The Machineries In and Out
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-19
    Song Gao; Junjie Hu

    Mitochondria are highly dynamic organelles that constantly undergo fission and fusion. Disruption of mitochondrial dynamics undermines their function and causes several human diseases. The fusion of the outer (OMM) and inner mitochondrial membranes (IMM) is mediated by two classes of dynamin-like protein (DLP): mitofusin (MFN)/fuzzy onions 1 (Fzo1) and optic atrophy 1/mitochondria genome maintenance

  • Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-19
    Sanjeethan C. Baksh; Lydia W.S. Finley

    Cell fate determination requires faithful execution of gene expression programs, which are increasingly recognized to respond to metabolic inputs. In particular, the family of α-ketoglutarate (αKG)-dependent dioxygenases, which include several chromatin-modifying enzymes, are emerging as key mediators of metabolic control of cell fate. αKG-dependent dioxygenases consume the metabolite αKG (also known

  • Tracking Mechanisms of Viral Dissemination In Vivo
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-10-03
    Raphael Gaudin; Jacky G. Goetz

    Dissemination and replication of viruses into hosts is a multistep process where viral particles infect, navigate, and indoctrinate various cell types. Viruses can reach tissues that are distant from their infection site by subverting subcellular mechanisms in ways that are, sometimes, disruptive. Modeling these steps, at appropriate resolution and within animal models, is cumbersome. Yet, mimicking

  • PhotoPROTACs: A Novel Biotechnology for Cancer Treatment.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-08-24
    Zhi-Wei Wang,Yi Liu,Xueqiong Zhu

    PROteolysis-TArgeting Chimeras (PROTACs) have been developed for targeting specific protein destruction. Two recent studies in Science Advances by Liu et al. and Reynders et al. reported a novel technology, PHOtochemically TArgeting Chimeras (PHOTACs) or opto-PROTAC, which is light-induced control of protein degradation. This new approach might lead to precision therapeutics in patients with cancer

  • Hematopoietic Reprogramming Entangles with Hematopoiesis.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-08-26
    Chuijin Wei,Pei Yu,Lin Cheng

    Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. The multiple processes that generate diverse hematopoietic cells have been considered to be unidirectional. However, many reports have recently demonstrated that these processes are not only reversible but also interconvertible via cell reprogramming

  • EMT, MET, Plasticity, and Tumor Metastasis.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-08-13
    Basil Bakir,Anna M Chiarella,Jason R Pitarresi,Anil K Rustgi

    Cancer cell identity and plasticity are required in transition states, such as epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET), in primary tumor initiation, progression, and metastasis. The functional roles of EMT, MET, and the partial state (referred to as pEMT) may vary based on the type of tumor, the state of dissemination, and the degree of metastatic colonization

  • A Senescence-Centric View of Aging: Implications for Longevity and Disease.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-08-13
    M Borghesan,W M H Hoogaars,M Varela-Eirin,N Talma,M Demaria

    Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. From their initial discovery in the 1960s, senescent cells have been hypothesized as potential contributors to the age-associated loss of regenerative potential. Here, we discuss recent evidence that implicates cellular senescence as a central

  • Golgi Outposts Nucleate Microtubules in Cells with Specialized Shapes.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-08-27
    Alex Valenzuela,Lindsey Meservey,Huy Nguyen,Meng-Meng Fu

    Classically, animal cells nucleate or form new microtubules off the perinuclear centrosome. In recent years, the Golgi outpost has emerged as a satellite organelle that can function as an acentrosomal microtubule-organizing center (MTOC), nucleating new microtubules at distances far from the nucleus or cell body. Golgi outposts can nucleate new microtubules in specialized cells with unique cytoarchitectures

  • Tight Junction Structure and Function Revisited.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-09-02
    Tetsuhisa Otani,Mikio Furuse

    Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, and additional players including junctional adhesion molecules (JAMs), membrane lipids

  • Principles of Leukocyte Migration Strategies.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-07-17
    Petra Kameritsch,Jörg Renkawitz

    Migration of leukocytes is essential for the induction, maintenance, and regulation of immune responses. On their trafficking routes, leukocytes encounter microenvironments of diverse mechanochemical composition, such as epithelial sheets, fibrillar networks, and cell-dense lymphatic organs. These microenvironments impose fundamental challenges on leukocytes, which include adhesive crawling under high

  • A Novel Paradigm for Expert Core Facility Staff Training.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-07-01
    Jennifer C Waters

    Scientific research relies on a range of technologies, many of which are developing at a fast pace. Technical experts able to advise researchers on experimental design and validate the performance1 of shared instruments are increasingly recognized as critical members of the research community. Here I describe a novel postdoctoral fellowship program designed to train expert imaging scientists, which

  • A Condensed View of the Chromosome Passenger Complex.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-07-17
    Prasad Trivedi,P Todd Stukenberg

    The inner centromere is a region on the mitotic chromosome that serves as a platform for mitotic signaling and possesses unique biophysical properties that enable it to withstand relatively large pulling forces that are generated by kinetochores (KTs) during chromosome segregation. The chromosomal passenger complex (CPC) localizes to and is the key regulator of inner centromere organization and function

  • Endoplasmic Reticulum (ER) Stress Response Failure in Diseases.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-06-16
    Kashi Raj Bhattarai,Manoj Chaudhary,Hyung-Ryong Kim,Han-Jung Chae

    Recent work provides evidence for the new terminology, ‘endoplasmic reticulum (ER) stress response or sensing failure’, in relation to metabolic disease. We seek to identify and amass possible conditions of ER stress response failure in various metabolic and age-related pathogenesis, including obesity and diabetes.

  • Polyploidy: A Biological Force From Cells to Ecosystems.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-07-06
    Donald T Fox,Douglas E Soltis,Pamela S Soltis,Tia-Lynn Ashman,Yves Van de Peer

    Polyploidy, resulting from the duplication of the entire genome of an organism or cell, greatly affects genes and genomes, cells and tissues, organisms, and even entire ecosystems. Despite the wide-reaching importance of polyploidy, communication across disciplinary boundaries to identify common themes at different scales has been almost nonexistent. However, a critical need remains to understand commonalities

  • The Roles of CD8+ T Cell Subsets in Antitumor Immunity.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-07-02
    Michael St Paul,Pamela S Ohashi

    Effector CD8+ T cells are typically thought to be a homogenous group of cytotoxic cells that produce interferon-(IFN) γ. However, recent findings have challenged this notion because multiple subsets of CD8+ T cells have been described, each with distinct effector functions and cytotoxic potential. These subsets, referred to as the Tc subsets, have also been detected in tumor microenvironments (TMEs)

  • Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-06-30
    Gwyn W Gould,Frances M Brodsky,Nia J Bryant

    Insulin stimulates glucose transport by triggering regulated delivery of intracellular vesicles containing the GLUT4 glucose transporter to the plasma membrane. This process is defective in diseases such as type 2 diabetes (T2DM). While studies in rodent cells have been invaluable in understanding GLUT4 traffic, evolutionary plasticity must be considered when extrapolating these findings to humans

  • Cytoskeletal Crosstalk in Cell Migration.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-07-13
    Shailaja Seetharaman,Sandrine Etienne-Manneville

    Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly comprises the actin microfilaments, microtubules, and intermediate filaments. During migration, cells polarize and form protrusions at the front, where new adhesions are formed. These nascent adhesions mature into focal adhesions that transmit the traction forces required for movement. All of these steps are coupled

  • Conformational Basis of G Protein-Coupled Receptor Signaling Versatility.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-07-02
    Laura M Wingler,Robert J Lefkowitz

    G protein-coupled receptors (GPCRs) are privileged structural scaffolds in biology that have the versatility to regulate diverse physiological processes. Interestingly, many GPCR ligands exhibit significant ‘bias’ – the ability to preferentially activate subsets of the many cellular pathways downstream of these receptors. Recently, complementary information from structural and spectroscopic approaches

  • Quantitative Data Analysis in Single-Molecule Localization Microscopy.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-08-20
    Yu-Le Wu,Aline Tschanz,Leonard Krupnik,Jonas Ries

    Super-resolution microscopy, and specifically single-molecule localization microscopy (SMLM), is becoming a transformative technology for cell biology, as it allows the study of cellular structures with nanometer resolution. Here, we review a wide range of data analyses approaches for SMLM that extract quantitative information about the distribution, size, shape, spatial organization, and stoichiometry

  • 更新日期:2020-08-18
  • 更新日期:2020-07-20
  • Extracellular Vesicles: New Bullets to Fight Fungal Infections.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-06-18
    Ramaroson Andriantsitohaina,Nicolas Papon

    While behaving as a commensal yeast in healthy people, Candida albicans remains the deadliest fungal pathogen in immunocompromised patients. Halder et al. deciphered unprecedented immunomodulatory properties of monocyte extracellular vesicles in response to Candida infections, paving the way to consider therapeutic innovations for fungal infections but also inflammatory diseases.

  • The Centriole Mystique.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-05-23
    Thoru Pederson

    Centrioles organize the microtubule network and mitotic spindle and, as basal bodies, nucleate cilia and flagella. They undergo a beguiling process in which one appears to give rise to another and at a baffling orthogonal geometry. Nucleic acid-based replication has been pondered during cycles of zeniths and nadirs of plausibility, the latter now the state. Centrioles can also arise de novo, and thus

  • Regulation and Consequences of cGAS Activation by Self-DNA.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-06-13
    Christian Zierhut,Hironori Funabiki

    Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major responder to the pathogenic DNA of viruses and bacteria. Upon DNA binding, cGAS becomes enzymatically active to generate the second messenger cGAMP, leading to activation of inflammatory genes, type I interferon production, autophagy, and cell death. Following genotoxic stress, cGAS can also respond to endogenous DNA, deriving from mitochondria, endogenous

  • Heterogeneity in mRNA Translation.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-05-25
    Stijn Sonneveld,Bram M P Verhagen,Marvin E Tanenbaum

    During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a single gene in an individual cell; multiple different

  • Investigating Cellular Recognition Using CRISPR/Cas9 Genetic Screening.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-06-25
    Zheng-Shan Chong,Gavin J Wright,Sumana Sharma

    Neighbouring cells can recognise and communicate with each other by direct binding between cell surface receptor and ligand pairs. Examples of cellular recognition events include pathogen entry into a host cell, sperm–egg fusion, and self/nonself discrimination by the immune system. Despite growing appreciation of cell surface recognition molecules as potential therapeutic targets, identifying key

  • Classical and Nonclassical Intercellular Communication in Senescence and Ageing.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-06-03
    Juan Antonio Fafián-Labora,Ana O'Loghlen

    Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context. The best characterized means of intercellular communication is the release of soluble

  • Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-06-05
    Michael J Emanuele,Taylor P Enrico,Ryan D Mouery,Danit Wasserman,Sapir Nachum,Amit Tzur

    The E2F family of transcriptional regulators sits at the center of cell cycle gene expression and plays vital roles in normal and cancer cell cycles. Whereas control of E2Fs by the retinoblastoma family of proteins is well established, much less is known about their regulation by ubiquitin pathways. Recent studies placed the Skp1-Cul1-F-box-protein (SCF) family of E3 ubiquitin ligases with the F-box

  • Membrane Architecture in the Spotlight of Correlative Microscopy.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-05-10
    Iva Ganeva,Wanda Kukulski

    Cellular membranes differ in their molecular organisation, shape, and dynamics. Knowing how these properties of membrane architecture relate to the presence and function of specific membrane components is fundamental for understanding membrane-associated cellular processes. Correlative light and electron microscopy (CLEM) is ideally poised to address such problems. Fluorescence microscopy allows identification

  • Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-05-05
    Geert J P L Kops,Reto Gassmann

    The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this ‘crown’ and what its relevance is for kinetochore

  • Turning the Oxygen Dial: Balancing the Highs and Lows.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-05-05
    Alan H Baik,Isha H Jain

    Oxygen is both vital and toxic to life. Molecular oxygen is the most used substrate in the human body and is required for several hundred diverse biochemical reactions. The discovery of the PHD-HIF-pVHL system revolutionized our fundamental understanding of oxygen sensing and cellular adaptations to hypoxia. It deepened our knowledge of the biochemical underpinnings of numerous diseases, ranging from

  • A Dynamical Paradigm for Molecular Cell Biology.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-04-30
    John J Tyson,Bela Novak

    The driving passion of molecular cell biologists is to understand the molecular mechanisms that control important aspects of cell physiology, but this ambition is often limited by the wealth of molecular details currently known about these mechanisms. Their complexity overwhelms our intuitive notions of how molecular regulatory networks might respond under normal and stressful conditions. To make progress

  • Metabolic Regulation of Tissue Stem Cells.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-04-28
    Suzanne N Shapira,Heather R Christofk

    Adult tissue stem cells mediate organ homeostasis and regeneration and thus are continually making decisions about whether to remain quiescent, proliferate, or differentiate into mature cell types. These decisions often integrate external cues, such as energy balance and the nutritional status of the organism. Metabolic substrates and byproducts that regulate epigenetic and signaling pathways are now

  • Fine-Tuning TOM-Mitochondrial Import via Ubiquitin.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-04-25
    Mohamed A Eldeeb,Andrew N Bayne,Jean-François Trempe,Edward A Fon

    Given their polyvalent functions, an inherent challenge that mitochondria face is the exposure to mitochondrial import stresses, culminating in their dysfunction. Recently, mitochondrial import of several mitochondrial substrates was shown to be regulated via a 'tug of war' between USP30 and MARCH5, two ubiquitin-related enzymes located at the TOM complex.

  • Noncanonical Cell Fate Regulation by Bcl-2 Proteins.
    Trends Cell Biol. (IF 16.041) Pub Date : 2020-04-16
    Stephen Jun Fei Chong,Saverio Marchi,Giulia Petroni,Guido Kroemer,Lorenzo Galluzzi,Shazib Pervaiz

    Bcl-2 proteins are widely known as key controllers of mitochondrial outer membrane permeabilization, arguably the most important step of intrinsic apoptosis. Accumulating evidence indicate that most, if not all, members of the Bcl-2 protein family also mediate a number of apoptosis-unrelated functions. Intriguingly, many of these functions ultimately impinge on cell fate decisions via apoptosis-dependent

Contents have been reproduced by permission of the publishers.
Springer 纳米技术权威期刊征稿