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Multicenter evaluation of an automated, multiplex, RNA-based molecular assay for detection of ALK, ROS1, RET fusions and MET exon 14 skipping in NSCLC Virchows Arch. (IF 3.5) Pub Date : 2024-03-16
Abstract The current study assessed the performance of the fully automated RT-PCR-based Idylla™ GeneFusion Assay, which simultaneously covers the advanced non-small cell lung carcinoma (aNSCLC) actionable ALK, ROS1, RET, and MET exon 14 rearrangements, in a routine clinical setting involving 12 European clinical centers. The Idylla™ GeneFusion Assay detects fusions using fusion-specific as well as
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Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities Virchows Arch. (IF 3.5) Pub Date : 2024-03-16 Alena Skálová, Abbas Agaimy, Martina Bradova, Vincent Vander Poorten, Ehab Hanna, Orlando Guntinas-Lichius, Alessandro Franchi, Henrik Hellquist, Roderick H. W. Simpson, Fernando Lopéz, Sandra Nuyts, Carlos Chiesa-Estomba, Sweet Ping Ng, Akihiro Homma, Yong Teng, Ilmo Leivo, Alfio Ferlito
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Clinical significance of location of perineural cancer invasion detected on prostate needle core biopsy Virchows Arch. (IF 3.5) Pub Date : 2024-03-15 Benjamin G. Gertsen, Yuki Teramoto, Ying Wang, Toyonori Tsuzuki, Hiroshi Miyamoto
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Epidermodysplasia verruciformis–associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features Virchows Arch. (IF 3.5) Pub Date : 2024-03-14 Eleanor Russell-Goldman, Esther Baranov, Stephanie Siegmund, Catherine S. Yang, Alvaro C. Laga, John Hanna
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The diagnostic utility of cytology specimen in a case of EWSR1::NFATC2 sarcoma Virchows Arch. (IF 3.5) Pub Date : 2024-03-14 Naoki Takeda, Naohiro Makise, Hajime Kageyama, Tsukasa Takahashi, Hiroshi Katoh, Akiko Odaka, Mariko Oikawa, Takahiro Sugiyama, Hidetada Kawana, Akinobu Araki, Hideyuki Kinoshita, Yoko Hagiwara, Hiroto Kamoda, Tsukasa Yonemoto, Makiko Itami
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Predominance of T-bet-positive Th1 cells in infiltrating T-lymphocytes in most of active arteritis lesions of giant cell arteritis Virchows Arch. (IF 3.5) Pub Date : 2024-03-13 Hidetoshi Satomi, Mikiko Kobayashi, Ichiro Ito, Koji Asano, Mutsuki Makino, Kenji Kawaguchi, Hiroyuki Kanno
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Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist Virchows Arch. (IF 3.5) Pub Date : 2024-03-12 Aitana López, Samuel López-Muñoz, Gabriela Caballero, Natalia Castrejon, Leonardo Rojo, Nuria Vidal-Robau, Abel Muñoz, Estrella Ortiz, Maite Rodrigo, Adriana García, Miriam Cuatrecasas, Teresa Ribalta, Iban Aldecoa
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Clinicopathological analysis of thyroid carcinomas with the RET and NTRK fusion genes: characterization for genetic analysis Virchows Arch. (IF 3.5) Pub Date : 2024-03-12 Yoichiro Okubo, Soji Toda, Mei Kadoya, Shinya Sato, Emi Yoshioka, Chie Hasegawa, Kyoko Ono, Kota Washimi, Tomoyuki Yokose, Yohei Miyagi, Katsuhiko Masudo, Hiroyuki Iwasaki, Hiroyuki Hayashi
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Mutational, immune microenvironment, and clinicopathological profiles of diffuse large B-cell lymphoma and follicular lymphoma with BCL6 rearrangement Virchows Arch. (IF 3.5) Pub Date : 2024-03-11
Abstract BCL6-rearrangement (BCL6-R) is associated with a favorable prognosis of follicular lymphoma (FL), but the mechanism is unknown. We analyzed the clinicopathological, immune microenvironment (immune checkpoint, immuno-oncology markers), and mutational profiles of 10 BCL6-R-positive FL, and 19 BCL6-R-positive diffuse large B-cell lymphoma (DLBCL) cases (both BCL2-R and MYC-R negative). A custom-made
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Molecular diagnostics of hepatobiliary and pancreatic neoplasias Virchows Arch. (IF 3.5) Pub Date : 2024-03-01 T. Longerich, A. Stenzinger, P. Schirmacher
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Correction to: Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles Virchows Arch. (IF 3.5) Pub Date : 2024-02-29 Carla Bartosch, Alfons Nadal, Ana C. Braga, Angela Salerno, Anne‑Laure Rougemont, Anne‑Sophie Van Rompuy, Brendan Fitzgerald, Caroline Joyce, Fabienne Allias, Geoffrey J. Maher, Gitta Turowski, Jean‑Christophe Tille, Kinan Drak Alsibai, Koen Van de Vijver, Lesley McMahon, Lone Sunde, Michal Pyzlak, Paul Downey, Sandra Wessman, Sophie Patrier, Baljeet Kaur, Rosemary Fisher
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Ovarian endometrioid carcinoma with a sex cord-like pattern: a morphological, immunohistochemical, and molecular analysis Virchows Arch. (IF 3.5) Pub Date : 2024-02-29 Antonio Travaglino, Damiano Arciuolo, Angela Santoro, Caterina Fulgione, Alessia Piermattei, Manuela Martinelli, Maria Elisabetta Onori, Angelo Minucci, Antonio Raffone, Frediano Inzani, Gian Franco Zannoni
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COVID-19 in the Netherlands: lessons from a nationwide query of dutch autopsy, histology, and cytology pathological reports Virchows Arch. (IF 3.5) Pub Date : 2024-02-27 Boaz Lopuhaä, Q. J. M. Voorham, Folkert J. van Kemenade, Jan H. von der Thüsen
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Granulation tissue-like spindle cell (sarcomatoid) carcinoma of the head and neck: a deceptively bland-looking underdiagnosed malignancy Virchows Arch. (IF 3.5) Pub Date : 2024-02-26 Alessandro Franchi, Abbas Agaimy
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Inflammatory/juvenile-like polyps in neurofibromatosis type 1 associated with epithelial dysplasia Virchows Arch. (IF 3.5) Pub Date : 2024-02-24 Diana Enea, Xavier Dray, Erell Guillerm, Antoine Guilloux, Matthieu Yver, Pascale Cervera, Magali Svrcek
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Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact Virchows Arch. (IF 3.5) Pub Date : 2024-02-24 Andrés Coca-Pelaz, Juan P. Rodrigo, Abbas Agaimy, Michelle D. Williams, Nabil F. Saba, Sandra Nuyts, Gregory W. Randolph, Fernando López, Vincent Vander Poorten, Luiz P. Kowalski, Francisco J. Civantos, Mark E. Zafereo, Antti A. Mäkitie, Oded Cohen, Iain J. Nixon, Alessandra Rinaldo, Alfio Ferlito
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Update on olfactory neuroblastoma Virchows Arch. (IF 3.5) Pub Date : 2024-02-22 Fernando Lopez, Abbas Agaimy, Alessandro Franchi, Carlos Suárez, Vincent Vander Poorten, Antti A. Mäkitie, Akihiro Homma, Avraham Eisbruch, Kerry D. Olsen, Nabil F. Saba, Sandra Nuyts, Carl Snyderman, Jonathan J. Beitler, June Corry, Ehab Hanna, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito
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Increased expression of CD70 in relapsed acute myeloid leukemia after hypomethylating agents Virchows Arch. (IF 3.5) Pub Date : 2024-02-22 Mario L. Marques-Piubelli, Bijender Kumar, Rafet Basar, Siler Panowski, Surabhi Srinivasan, Kevin Norwood, Sacha Prashad, Victoria Szenes, Arun Balakumaran, Akanksha Arandhya, Wei Lu, Khaja Khan, Daniela Duenas, Salome McAllen, Javier A Gomez, Jared K. Burks, Sunil Acharyal, Gautam Borthakur, Wei-Lien Wang, Wei Wang, Sa Wang, Luisa M. Solis, David Marin, Katayoun Rezvani, May Daher, Francisco Vega
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Biphasic papillary (biphasic squamoid alveolar) renal cell carcinoma: a clinicopathologic and molecular study of 17 renal cell carcinomas including 10 papillary adenomas Virchows Arch. (IF 3.5) Pub Date : 2024-02-22 Luiz M. Nova-Camacho, Andres M. Acosta, Mahmut Akgul, Angel Panizo, Laurence A. Galea, Andrea Val-Carreres, Juan A. Talavera, David Guerrero-Setas, Maialen Martin-Arruti, Irune Ruiz, María García-Martos, Ankur R. Sangoi
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Tumor stroma ratio, tumor stroma maturity, tumor-infiltrating immune cells in relation to prognosis, and neoadjuvant therapy response in esophagogastric junction adenocarcinoma Virchows Arch. (IF 3.5) Pub Date : 2024-02-21
Abstract Accurate predictions on prognosis and neoadjuvant therapy response are crucial for esophagogastric junction adenocarcinoma (EGJA) patients. Therefore, we aimed to investigate the predictive abilities of several indicators, including tumor stroma ratio (TSR), tumor stroma maturity (TSM), and the density and spatial distribution of tumor-infiltrating immune cells (TIICs), such as T cells, B
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Myeloid sarcoma with RBM15::MRTFA (MKL1) mimicking vascular neoplasm Virchows Arch. (IF 3.5) Pub Date : 2024-02-20
Abstract Extramedullary involvement of acute myeloid leukemia (AML), aka myeloid sarcoma, is a rare phenomenon in acute megakaryoblastic leukemia with RBM15:: MRTFA(MKL1) fusion, which might mimic non-hematologic malignancies. A 7-month-old infant presented with leukocytosis, hepatosplenomegaly, multiple lymphadenopathies, and a solid mass in the right thigh. Initially, the patient was diagnosed with
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Exploring the histogenesis of STK11 adnexal tumour using electron microscopy Virchows Arch. (IF 3.5) Pub Date : 2024-02-20 Nuria Mascaro, Lamia Sabry Aboelnasr, Motasim Masood, Ernesto Yague, Linda Moran, Mona El-Bahrawy
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Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study Virchows Arch. (IF 3.5) Pub Date : 2024-02-16
Abstract Differentiating BRAF V600E- and RAS-altered encapsulated follicular-patterned thyroid tumors based on morphology remains challenging. This study aimed to validate an 8-score scale nuclear scoring system and investigate the importance of nuclear pseudoinclusions (NPIs) in aiding this differentiation. A cohort of 44 encapsulated follicular-patterned tumors with varying degrees of nuclear atypia
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Optimizing the management of thyroid specimens to efficiently generate whole slide images for diagnosis Virchows Arch. (IF 3.5) Pub Date : 2024-02-14
Abstract Transition from optical to digital observation requires an additional procedure in the pathology laboratory, the scanning of glass slides, leading to increased time and digital archive consumption. Thyroid surgical samples often carry the need to collect several tissue fragments that generate many slides to be scanned. This study evaluated the impact of using different inking colours for the
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Extraskeletal chondroma of the toe in a child with DICER1 tumor predisposition syndrome: support for a dominant negative mechanism Virchows Arch. (IF 3.5) Pub Date : 2024-02-14 Dylan Pelletier, Nelly Sabbaghian, Anne-Laure Chong, John R. Priest, Yomna Elsheikh Ahmed, Gabriel P. Fox, Marc R. Fabian, William D. Foulkes
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Loss of or decrease in CD30 expression in four patients with anaplastic large cell lymphoma after brentuximab vedotin-containing therapy Virchows Arch. (IF 3.5) Pub Date : 2024-02-13 Yuto Kaimi, Yuka Takahashi, Hirokazu Taniguchi, Tetsuro Ochi, Haruhi Makino, Shinichi Makita, Noriko Iwaki, Suguru Fukuhara, Wataru Munakata, Chitose Ogawa, Koji Izutsu, Akiko Miyagi Maeshima
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Heterogeneity of molecular subtyping and therapy-related marker expression in primary tumors and paired lymph node metastases of small cell lung cancer Virchows Arch. (IF 3.5) Pub Date : 2024-02-13 Yanli Zhu, Wenhao Ren, Sheng Li, Jianghua Wu, Xiao Hu, Haiyue Wang, Kaiwen Chi, Minglei Zhuo, Dongmei Lin
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Comparative epigenomics indicate a common origin of ectopic and intrasellar corticotroph pituitary neuroendocrine tumors/adenomas: a case report Virchows Arch. (IF 3.5) Pub Date : 2024-02-12 Alonso Barrantes-Freer, Max Braune, Benjamin Sandner, Matthias Dottermusch, Dirk Lindner
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Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone: retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications Virchows Arch. (IF 3.5) Pub Date : 2024-02-09 Laura S. Hiemcke-Jiwa, Vaiyapuri P. Sumathi, Daniel Baumhoer, Stephanie E. Smetsers, Lianne M. Haveman, Max M. van Noesel, Kirsten van Langevelde, Arjen H. G. Cleven, Michiel A. J. van de Sande, Simone A. J. ter Horst, Lennart A. Kester, Uta Flucke
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Deep learning model to differentiate Crohn’s disease from intestinal tuberculosis using histopathological whole slide images from intestinal specimens Virchows Arch. (IF 3.5) Pub Date : 2024-02-08
Abstract Crohn’s disease (CD) and intestinal tuberculosis (ITB) share similar histopathological characteristics, and differential diagnosis can be a dilemma for pathologists. This study aimed to apply deep learning (DL) to analyze whole slide images (WSI) of surgical resection specimens to distinguish CD from ITB. Overall, 1973 WSI from 85 cases from 3 centers were obtained. The DL model was established
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Pigmented dentinogenic ghost cell tumor: a unique case report and a review of the literature Virchows Arch. (IF 3.5) Pub Date : 2024-02-07 Yassmin Abdalla Mustafa Mohamed, Mohamed Mogahid Abdelrahman Yousif, Nazik Omer Elbashir, Abeer Hemedan Mohammed Ahmed, Ahmed Eltayeb Ali, Ahmed Mohamed Suleiman
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Spatial expression of claudin 18.2 in matched primaries and metastases of tubo-ovarian carcinoma of all subtypes Virchows Arch. (IF 3.5) Pub Date : 2024-02-07 Paul Wagner, Paul Gass, Patrik Pöschke, Markus Eckstein, Laura Gloßner, Arndt Hartmann, Matthias Wilhelm Beckmann, Peter Andreas Fasching, Matthias Ruebner, Julius Emons, Ramona Erber
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Molecular pathological classification of colorectal cancer—an update Virchows Arch. (IF 3.5) Pub Date : 2024-02-06
Abstract Colorectal cancer (CRC) has a broad range of molecular alterations with two major mechanisms of genomic instability (chromosomal instability and microsatellite instability) and has been subclassified into 4 consensus molecular subtypes (CMS) based on bulk RNA sequence data. Here, we update the molecular pathological classification of CRC with an overview of more recent bulk and single-cell
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IgG4-related disease: an update on pathology and diagnostic criteria with a focus on salivary gland manifestations Virchows Arch. (IF 3.5) Pub Date : 2024-02-05 Agata Czarnywojtek, Abbas Agaimy, Krzysztof Pietrończyk, Iain J. Nixon, Vincent Vander Poorten, Antti A. Mäkitie, Mark Zafereo, Ewa Florek, Nadia Sawicka-Gutaj, Marek Ruchała, Alfio Ferlito
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Mallory-Denk bodies and hepatocellular senescence: a causal relationship? Virchows Arch. (IF 3.5) Pub Date : 2024-01-30 Helmut Denk, Peter M. Abuja, Kurt Zatloukal
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Histopronostic factors in superficial colorectal adenocarcinomas treated by endoscopy: reproducibility and impact of immunohistochemistry and digital pathology Virchows Arch. (IF 3.5) Pub Date : 2024-01-26 Guillaume Pontarollo, Maxime Bonjour, Thomas Walter, Mathieu Pioche, Pierre-Marie Lavrut, Maud Rabeyrin, Valérie Hervieu, Tanguy Fenouil
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Grade group 4 prostate cancer without intraductal carcinoma on biopsy is more likely to be downgraded on prostatectomy than with intraductal carcinoma Virchows Arch. (IF 3.5) Pub Date : 2024-01-25 Levent Trabzonlu, Thanchanok Chaiprasit, Andreas Kontosis, Maria Picken
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Gastroblastoma with a novel ACTB::GLI1 gene fusion in a 19-year-old male Virchows Arch. (IF 3.5) Pub Date : 2024-01-23 Junaid Shabbir, Jonathan Earle, Krzysztof Glomski, Laila Mnayer, Bret Schipper, Saverio Ligato
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Syndromic MEN1 parathyroid adenomas consist of both subclonal nodules and clonally independent tumors Virchows Arch. (IF 3.5) Pub Date : 2024-01-20 Konstantin Bräutigam, Cédric Nesti, Philipp Riss, Christian Scheuba, Bruno Niederle, Tobias Grob, Annunziata Di Domenico, Maja Neuenschwander, Peter Mazal, Nastassja Köhn, Roman Trepp, Aurel Perren, Reto M. Kaderli
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H3 K27M mutation in rosette-forming glioneuronal tumors: a potential diagnostic pitfall Virchows Arch. (IF 3.5) Pub Date : 2024-01-17 Elena Marastoni, Serena Ammendola, Sabrina Rossi, Isabella Giovannoni, Giuseppe Broggi, Barbara Masotto, Alberto Feletti, Valeria Barresi
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Current challenges and practical aspects of molecular pathology for bone and soft tissue tumors Virchows Arch. (IF 3.5) Pub Date : 2024-01-16 Enrique de Álava
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Molecular pathology in diagnosis and prognostication of head and neck tumors Virchows Arch. (IF 3.5) Pub Date : 2024-01-13 Alena Skálová, Martina Bradová, Michael Michal, Elaheh Mosaieby, Natálie Klubíčková, Tomáš Vaněček, Ilmo Leivo
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Intratumoral heterogeneity of Ki67 proliferation index outperforms conventional immunohistochemistry prognostic factors in estrogen receptor-positive HER2-negative breast cancer Virchows Arch. (IF 3.5) Pub Date : 2024-01-13 Dovile Zilenaite-Petrulaitiene, Allan Rasmusson, Justinas Besusparis, Ruta Barbora Valkiuniene, Renaldas Augulis, Aida Laurinaviciene, Benoit Plancoulaine, Linas Petkevicius, Arvydas Laurinavicius
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ETV6::NTRK3-associated papillary adenocarcinoma: let us play it by ear Virchows Arch. (IF 3.5) Pub Date : 2024-01-11 Diana Bell, Ellie Maghami, Rania Bakkar, Michelle Afkhami
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Comparison of the 7th and revised 8th UICC editions (2020) for oral squamous cell carcinoma: How does the reclassification impact staging and survival? Virchows Arch. (IF 3.5) Pub Date : 2024-01-08
Abstract Since its introduction in 1968, the TNM (tumor, node, metastasis) classification established by the International Union Against Cancer has provided a consistent framework for staging of oral squamous cell carcinoma (OSCC). The introduction of the 8th edition in 2017 brought about significant modifications, encompassing the integration of depth of invasion (DOI) and extranodal extension (ENE)
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CTNNB1 mutation-driven hybrid tumor: desmoid fibromatosis with an unusual associated epithelioid component arising in association with a neuromuscular choristoma Virchows Arch. (IF 3.5) Pub Date : 2024-01-06 Xuanxuan Zheng, Xin He, Yang Lu, Chang Chen, Hongying Zhang
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Low incidence of BRAF and NRAS mutations in a population with a high incidence of melanoma Virchows Arch. (IF 3.5) Pub Date : 2024-01-06
Abstract Reported rates of BRAF mutation in Irish cutaneous melanoma cohorts are lower than the reported international data. We aimed to assess the mutational status of a cohort of primary cutaneous melanomas and to correlate it with clinical follow-up data. A total of 92 cases of primary cutaneous melanoma diagnosed at a single institution in 2012 were analyzed. Regions containing common mutations
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Characterization of two transcriptomic subtypes of marker-null large cell carcinoma of the lung suggests different origin and potential new therapeutic perspectives Virchows Arch. (IF 3.5) Pub Date : 2024-01-03 Michele Simbolo, Giovanni Centonze, Anastasios Gkountakos, Valentina Monti, Patrick Maisonneuve, Stela Golovco, Giovanna Sabella, Alessandro Del Gobbo, Stefano Gobbo, Stefano Ferrero, Alessandra Fabbri, Carlotta Pardo, Giovanna Garzone, Natalie Prinzi, Sara Pusceddu, Adele Testi, Luigi Rolli, Alessandro Mangogna, Luisa Bercich, Mauro Roberto Benvenuti, Emilio Bria, Sara Pilotto, Alfredo Berruti, Ugo
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Giant bilateral prepubertal-type teratomas in a postpubertal patient: An illustrative case and review of the literature Virchows Arch. (IF 3.5) Pub Date : 2024-01-02 Katrina Collins, William J. Anderson, Michelle S. Hirsch, Thomas M. Ulbright, Andres M. Acosta
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NTRK-rearranged spindle cell sarcoma of the uterine cervix with a novel NUMA1::NTRK1 fusion Virchows Arch. (IF 3.5) Pub Date : 2023-12-28 Luca Szalai, Ildikó Vereczkey, Marianna Szemes, András Rókusz, Erzsébet Csernák, Erika Tóth, Zsombor Melegh
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Prevalence and type of MMR expression heterogeneity in colorectal adenocarcinoma: therapeutic implications and reporting Virchows Arch. (IF 3.5) Pub Date : 2023-12-23 Federica Grillo, Valentina Angerilli, Paola Parente, Alessandro Vanoli, Claudio Luchini, Stefania Sciallero, Alberto Puccini, Francesca Bergamo, Sara Lonardi, Nicola Valeri, Luca Mastracci, Matteo Fassan
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Analysis of GATA3 and FOXA2 expression suggests that downregulation of genes involved in the maintenance of a mature yolk sac tumor phenotype may underlie sarcomatoid transformation Virchows Arch. (IF 3.5) Pub Date : 2023-12-23 Costantino Ricci, Francesca Ambrosi, Alessia Grillini, Francesco Massari, Michelangelo Fiorentino, Maurizio Colecchia, Thomas M. Ulbright, Andres Martin Acosta
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Swiss digital pathology recommendations: results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology Virchows Arch. (IF 3.5) Pub Date : 2023-12-19 Andrew Janowczyk, Inti Zlobec, Cedric Walker, Sabina Berezowska, Viola Huschauer, Marianne Tinguely, Joel Kupferschmid, Thomas Mallet, Doron Merkler, Mario Kreutzfeldt, Radivoje Gasic, Tilman T. Rau, Luca Mazzucchelli, Isgard Eyberg, Gieri Cathomas, Kirsten D. Mertz, Viktor H. Koelzer, Davide Soldini, Wolfram Jochum, Matthias Rössle, Maurice Henkel, Rainer Grobholz
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Shedding light on PRAME expression in dysplastic nevi: a cohort study Virchows Arch. (IF 3.5) Pub Date : 2023-12-19
Abstract Dysplastic nevi represent one of the least agreed-upon entities in dermatopathology despite the existence of established criteria. This study explores preferentially expressed antigen in melanoma (PRAME) in dysplastic nevi, an uncharted area. We examined 22 common melanocytic nevi (CMN), 20 cutaneous melanomas (CM), 48 low-grade dysplastic nevi (LG-DN), and 40 high-grade dysplastic nevi (HG-DN)
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Molecular pathology of endocrine gland tumors: genetic alterations and clinicopathologic relevance Virchows Arch. (IF 3.5) Pub Date : 2023-12-18 Antonio De Leo, Martina Ruscelli, Thais Maloberti, Sara Coluccelli, Andrea Repaci, Dario de Biase, Giovanni Tallini
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Mutated ASXL1 upregulates mTOR expression in renal cell carcinoma with fibromyomatous stroma Virchows Arch. (IF 3.5) Pub Date : 2023-12-16 Yang Liu, Luting Zhou, Haimin Xu, Yijin Gu, Lei Dong, Xiaoqun Yang, Chaofu Wang
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Molecular features for timely cancer diagnosis and treatment – tumors of the ovary, fallopian tube and endometrium Virchows Arch. (IF 3.5) Pub Date : 2023-12-15
Abstract Gynecologic pathology has moved, within only a few years, from being a diagnostic area devoid of molecular testing into a diagnostic discipline in which such analyses are becoming routine. The direct relevance of molecular characterization to the choice of treatment of patients with carcinomas originating in both the uterus and adnexae makes it likely that such testing will only expand along
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Molecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum Virchows Arch. (IF 3.5) Pub Date : 2023-12-14
Abstract Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case of high hCG serum levels, the presence of a non-SEM component, i.e. choriocarcinoma (CC), may be assumed. To characterize cases described as pure seminoma with high serum hCG levels, tissue samples and DNA were analyzed. Patient files from an international
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SMARCB1-deficient sinonasal adenocarcinoma: a rare variant of SWI/SNF-deficient malignancy often misclassified as high-grade non-intestinal-type sinonasal adenocarcinoma or myoepithelial carcinoma Virchows Arch. (IF 3.5) Pub Date : 2023-12-12 Alena Skálová, Touraj Taheri, Martina Bradová, Tomáš Vaněček, Alessandro Franchi, David Slouka, Tomáš Kostlivý, Gisele de Rezende, Jaroslav Michálek, Natálie Klubíčková, Nicola Ptáková, Antónia Nemcová, Michal Michal, Abbas Agaimy, Ilmo Leivo
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SATB2, CKAE1/AE3, and synaptophysin as a sensitive immunohistochemical panel for the detection of lymph node metastases of Merkel cell carcinoma Virchows Arch. (IF 3.5) Pub Date : 2023-12-08 Anna Szumera-Cieckiewicz, Daniela Massi, Angelo Cassisa, Mateusz Krzyzinski, Monika Dudzisz-Sledz, Przemyslaw Biecek, Piotr Rutkowski, Andrzej Marszalek, Mai P. Hoang, Piotr Donizy