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Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis Apoptosis (IF 4.543) Pub Date : 2021-01-11 Joshua A. Grosser, Margaret E. Maes, Robert W. Nickells
Recent advancements in live cell imaging technologies have identified the phenomenon of intracellular propagation of late apoptotic events, such as cytochrome c release and caspase activation. The mechanism, prevalence, and speed of apoptosis propagation remain unclear. Additionally, no studies have demonstrated propagation of the pro-apoptotic protein, BAX. To evaluate the role of BAX in intracellular
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H 2 S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434 Apoptosis (IF 4.543) Pub Date : 2021-01-03 Na Li, JuYuan Wang, XiaoLing Zang, ZhaoYang Wang, Tao Zhang, BaoXiang Zhao, JunYing Miao, ZhaoMin Lin
H2S is actual an endogenous signaling gas molecule and involved in a range of cell physiological processes. However, the mechanism of endogenous H2S regulating autophagy and apoptosis has not been thoroughly investigated. Here, we try to address this issue by using a H2S probe, (E)-2-(4-(4-(7-(diethylamino)-2-oxo-2H-chromene-3-carbonyl)-piperazin-1-yl)-styryl)-1, 3, 3-trimethyl-3H-indol-1-ium iodide
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The role of the DFF40/CAD endonuclease in genomic stability Apoptosis (IF 4.543) Pub Date : 2021-01-02 Merve Kulbay, Nathan Bernier-Parker, Jacques Bernier
Maintenance of genomic stability in cells is primordial for cellular integrity and protection against tumor progression. Many factors such as ultraviolet light, oxidative stress, exposure to chemical reagents, particularly mutagens and radiation, can alter the integrity of the genome. Thus, human cells are equipped with many mechanisms that prevent these irreversible lesions in the genome, as DNA repair
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Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells Apoptosis (IF 4.543) Pub Date : 2021-01-02 José Saura-Esteller, Ismael Sánchez-Vera, Sonia Núñez-Vázquez, Judith Jabalquinto-Carrasco, Ana M. Cosialls, Lorena Mendive-Tapia, Dmytro Kukhtar, Manuel D. Martínez-Bueno, Rodolfo Lavilla, Julián Cerón, Marta Artal-Sanz, Gabriel Pons, Daniel Iglesias-Serret, Joan Gil
We previously showed that fluorizoline, a fluorinated thiazoline compound, binds to both subunits of the mitochondrial prohibitin (PHB) complex, PHB1 and PHB2, being the expression of these proteins required for fluorizoline-induced apoptosis in mouse embryonic fibroblasts. To investigate the conservation of this apoptotic mechanism, we studied the effect of PHB downregulation on fluorizoline activity
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Triclosan induces apoptosis in Burkitt lymphoma-derived BJAB cells through caspase and JNK/MAPK pathways Apoptosis (IF 4.543) Pub Date : 2021-01-02 Mohammad A. Alfhili, Hosni A. M. Hussein, Youngyong Park, Myon Hee Lee, Shaw M. Akula
Burkitt's lymphoma (BL) is the fastest growing human tumor. Current treatment consists of a multiagent regimen of cytotoxic drugs with serious side effjects including tumor lysis, cardiotoxicity, hepatic impairment, neuropathy, myelosuppression, increased susceptibility to malignancy, and death. Furthermore, therapeutic interventions in areas of BL prevalence are not as feasible as in high-income countries
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Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis Apoptosis (IF 4.543) Pub Date : 2021-01-01 Ronald Jemmerson, Katherine Staskus, LeeAnn Higgins, Kathleen Conklin, Ameeta Kelekar
Leucine-rich alpha-2-glycoprotein-1 (LRG1) has been shown to compete with apoptosis activating factor-1 (Apaf-1) for binding cytochrome c (Cyt c) and could play a role in inhibition of apoptosis. Employing MCF-7 breast cancer cells, we report that intracellular LRG1 does protect against apoptosis. Thus, cells transfected with the lrg1 gene and expressing higher levels of LRG1 were more resistant to
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The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD + redox state Apoptosis (IF 4.543) Pub Date : 2020-11-23 Simei Go, Thorquil T. Kramer, Arthur J. Verhoeven, Ronald P. J. Oude Elferink, Jung-Chin Chang
The advantages of the Warburg effect on tumor growth and progression are well recognized. However, the relevance of the Warburg effect for the inherent resistance to apoptosis of cancer cells has received much less attention. Here, we show here that the Warburg effect modulates the extracellular lactate-to-pyruvate ratio, which profoundly regulates the sensitivity towards apoptosis induced by oxidative
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Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death Apoptosis (IF 4.543) Pub Date : 2020-11-23 Sahabuddin Ahmed, Mohit Kwatra, Basveshwar Gawali, Samir Ranjan Panda, V. G. M. Naidu
Striatal neurons depends on an afferent supply of brain-derived neurotrophic factor-(BDNF) that explicitly interacts with tropomyosin receptor kinase B (TrkB) receptor and performs sundry functions including synaptic plasticity, neuronal differentiation and growth. Therefore, we aimed to scrutinize an active molecule that functions identical to BDNF in activating TrkB receptor and it’s downstream targets for
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The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells Apoptosis (IF 4.543) Pub Date : 2020-11-06 Karol Prieto, Maria Paula Lozano, Claudia Urueña, Carlos Javier Alméciga-Díaz, Susana Fiorentino, Alfonso Barreto
P2Et extract obtained from the Caesalpinia spinosa plant is abundant in phenolic compounds such as gallic acid and ethyl gallate and can generate signals to activate the immune response by inducing a mechanism known as immunogenic cell death in murine models of breast cancer and melanoma. Immunogenic cell death involves mechanisms such as autophagy, which can be modulated by various natural compounds
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Functional characterization of the Drosophila suzukii pro-apoptotic genes reaper , head involution defective and grim Apoptosis (IF 4.543) Pub Date : 2020-10-28 Syeda A. Jaffri, Ying Yan, Jonas Schwirz, Marc F. Schetelig
Apoptosis is a fundamental process for the elimination of damaged or unwanted cells, and is a key aspect of development. It is triggered by pro-apoptotic genes responding to the intrinsic pathway that senses cell stress or the extrinsic pathway that responds to signals from other cells. The disruption of these genes can therefore lead to developmental defects and disease. Pro-apoptotic genes have been
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Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway Apoptosis (IF 4.543) Pub Date : 2020-10-17 Ying Li, Qi Qi, Wan-cheng Yang, Tian-liang Zhang, Chen-chen Lu, Yu-juan Yao, Wei-hua Kong, Jing Zhao
Blockade of hypoxia-caused nonmyocytes apoptosis helps improve survival and mitigate ventricular remodeling and dysfunction during the chronic stage of myocardial infarction. But tools affecting nonmyocyte apoptosis are very rare. Sphingosylphosphorylcholine (SPC), a naturally occurring bioactive sphingolipid in plasma, was proved to protect cardiomyocyte against apoptosis in an ischemic model in our
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Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside. Apoptosis (IF 4.543) Pub Date : 2020-09-21 Marta Orlicka-Płocka,Dorota Gurda-Wozna,Agnieszka Fedoruk-Wyszomirska,Eliza Wyszko
Small-molecule compound-based therapies have provided new insights into cancer treatment against mitochondrial impairment. N6-furfuryladenosine (kinetin riboside, KR) is a purine derivative and an anticancer agent that selectively affects the molecular pathways crucial for cell growth and apoptosis by interfering with mitochondrial functions and thus might be a potential mitotoxicant. Metabolism of
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The function and mechanism of ferroptosis in cancer. Apoptosis (IF 4.543) Pub Date : 2020-09-17 Ying Wang,Zihao Wei,Keran Pan,Jing Li,Qianming Chen
Ferroptosis is a newly defined form of regulated cell death (RCD) characterized by iron overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation, which is different from necrosis, apoptosis, autophagy and other forms of RCD in morphology, biochemistry, function and gene expression. Increasing evidence has shown that ferroptosis is intimately associated with cancer initiation
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Maslinic acid differentially exploits the MAPK pathway in estrogen-positive and triple-negative breast cancer to induce mitochondrion-mediated, caspase-independent apoptosis. Apoptosis (IF 4.543) Pub Date : 2020-09-17 R Jain,A Grover
Breast cancer accounts for 1.4 million new cases every year. Triple-negative breast cancer (TNBC) is one the leading cause of mortality in developing countries and is associated with early age onset (under 40 years old). Chemotherapy has a poor success rate in patients with TNBC as compared to other types of breast cancers. It is due to the lack of expression of three validated molecular markers for
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RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells. Apoptosis (IF 4.543) Pub Date : 2020-09-08 Sehime Gulsun Temel,Aslı Giray,Bahriye Karakas,Ozgur Gul,Ilknur Kozanoglu,Husnu Celik,Huveyda Basaga,Ufuk Acikbas,Ceren Sucularli,Sidika Oztop,Yeliz Aka,Ozgur Kutuk
Ovarian cancer remains one of the most frequent causes of cancer-related death in women. Many patients with ovarian cancer suffer from de novo or acquired resistance to chemotherapy. Here, we report that RAB25 suppresses chemotherapy-induced mitochondrial apoptosis signaling in ovarian cancer cell lines and primary ovarian cancer cells. RAB25 blocks chemotherapy-induced apoptosis upstream of mitochondrial
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Epoxyazadiradione exhibit activities in head and neck squamous cell carcinoma by targeting multiple pathways. Apoptosis (IF 4.543) Pub Date : 2020-09-07 Vipin Rai,Sushil Kumar Aggarwal,Sumit Singh Verma,Nikee Awasthee,Anupam Dhasmana,Sadhna Aggarwal,Satya N Das,Mangalam S Nair,Sanjay Yadav,Subash C Gupta
The head and neck squamous cell carcinoma (HNSCC) constitute about 90% of all head and neck cancers. HNSCC falls in the top 10 cancers in men globally. Epoxyazadiradione (EPA) and Azadiradione (AZA) are the limonoids derived from the medicinal plant Azadirachta indica (popularly known as Neem). Whether or not the limonoids exhibit activities against HNSCC and the associated mechanism remains elusive
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Interconnections among major forms of regulated cell death. Apoptosis (IF 4.543) Pub Date : 2020-09-05 Chaoyi Wu,Liting Zhou,Haibo Yuan,Shuyan Wu
As a basic biological phenomenon of cells, regulated cell death (RCD) has irreplaceable influence on the occurrence and development of many processes of life and diseases. RCD plays an important role in the stability of the homeostasis, the development of multiple systems and the evolution of organisms. Thus comprehensively understanding of RCD is undoubtedly helpful in the innovation of disease treatment
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Photodynamic therapy: apoptosis, paraptosis and beyond. Apoptosis (IF 4.543) Pub Date : 2020-09-04 David Kessel
Photodynamic therapy (PDT) is a light-catalyzed process that can initiate cellular death pathways from the formation of cytotoxic reactive oxygen species at sub-cellular sites. Apoptosis was the first such pathway to be identified. Autophagy can also occur and is often found to be cytoprotective. Another process termed paraptosis can also have lethal consequences, even in cells with an impaired apoptotic
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Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes. Apoptosis (IF 4.543) Pub Date : 2020-08-20 J Rzemieniec,E Bratek,A Wnuk,K Przepiórska,E Salińska,M Kajta
Each year, 1 million children die due to perinatal asphyxia; however, there are no effective drugs to protect the neonatal brain against hypoxic/ischemic damage. In this study, we demonstrated for the first time the neuroprotective capacity of 3,3’-diindolylmethane (DIM) in an in vivo model of rat perinatal asphyxia, which has translational value and corresponds to hypoxic/ischemic episodes in human
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Acetylcholinesterase promotes apoptosis in insect neurons. Apoptosis (IF 4.543) Pub Date : 2020-08-05 Debbra Y Knorr,Nadine S Georges,Stephanie Pauls,Ralf Heinrich
Apoptosis plays a major role in development, tissue renewal and the progression of degenerative diseases. Studies on various types of mammalian cells reported a pro-apoptotic function of acetylcholinesterase (AChE), particularly in the formation of the apoptosome and the degradation of nuclear DNA. While three AChE splice variants are present in mammals, invertebrates typically express two ache genes
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BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis. Apoptosis (IF 4.543) Pub Date : 2020-07-31 Young-Sun Lee,Kalishwaralal Kalimuthu,Yong Seok Park,Xu Luo,M Haroon A Choudry,David L Bartlett,Yong J Lee
Ferroptosis is considered a distinctive form of cell death compared to other types of death such as apoptosis. It is known to result from iron-dependent accumulation of lipid peroxides rather than caspase activation. However, we reported recently that ferroptosis interplays with apoptosis. In this study, we investigated a possible mechanism of this interplay between ferroptosis and apoptosis. Results
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Regulatory T cells are less sensitive to glucocorticoid hormone induced apoptosis than CD4+ T cells. Apoptosis (IF 4.543) Pub Date : 2020-07-31 Lilla Prenek,Tímea Litvai,Noémi Balázs,Réka Kugyelka,Ferenc Boldizsár,József Najbauer,Péter Németh,Timea Berki
Earlier we have reported that thymic regulatory T cells (Treg) are resistant to in vivo glucocorticoid hormone (GC)-induced apoptosis, while the most GC-sensitive DP thymocytes died through the activation of mitochondrial apoptotic pathway. Here we analyzed the apoptosis-inducing effect of high dose (10–6 M) in vitro dexamethasone (DX) treatment in mouse thymic- and splenic Tregs and CD4+ T cells.
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Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis. Apoptosis (IF 4.543) Pub Date : 2020-07-25 Simona Dedoni,Luisa Marras,Maria C Olianas,Angela Ingianni,Pierluigi Onali
The antiepileptic and mood stabilizer agent valproic acid (VPA) has been shown to exert anti-tumour effects and to cause neuronal damage in the developing brain through mechanisms not completely understood. In the present study we show that prolonged exposure of SH-SY5Y and LAN-1 human neuroblastoma cells to clinically relevant concentrations of VPA caused a marked induction of the protein and transcript
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Correction to: A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis. Apoptosis (IF 4.543) Pub Date : 2020-07-18 Zhongjie Yu,Qi Li,Yin Wang,Peifeng Li
The original version of this article unfortunately contains errors in methods and figures. In methods, animal experiments part: “2 ml/kg” and “after two days” were described incorrectly which were actually “4 ml/kg” and “after eight days” respectively.
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In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. Apoptosis (IF 4.543) Pub Date : 2020-07-14 Maurizio D Baroni,Sonia Colombo,Olivier Libens,Rani Pallavi,Marco Giorgio,Enzo Martegani
Caloric restriction mimetics (CRMs) are promising molecules to prevent age-related diseases as they activate pathways driven by a true caloric restriction. Hydroxycitric acid (HCA) is considered a bona fide CRM since it depletes acetyl-CoA pools by acting as a competitive inhibitor of ATP citrate lyase (ACLY), ultimately repressing protein acetylation and promoting autophagy. Importantly, it can reduce
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The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis. Apoptosis (IF 4.543) Pub Date : 2020-07-07 Mehrdad Ghashghaeinia,Pavla Koralkova,Daniela Giustarini,Renata Mojzikova,Birgit Fehrenbacher,Peter Dreischer,Martin Schaller,Ulrich Mrowietz,Antonio Martínez-Ruiz,Thomas Wieder,Vladimir Divoky,Ranieri Rossi,Florian Lang,Martin Köberle
Costunolide, a natural sesquiterpene lactone, has multiple pharmacological activities such as neuroprotection or induction of apoptosis and eryptosis. However, the effects of costunolide on pro-survival factors and enzymes in human erythrocytes, e.g. glutathione and glucose-6-phosphate dehydrogenase (G6PDH) respectively, have not been studied yet. Our aim was to determine the mechanisms underlying
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Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax. Apoptosis (IF 4.543) Pub Date : 2020-07-06 Bo Wang,Dan Han,Fei Li,Weikun Hou,Lijuan Wang,Liesu Meng,Kuanhou Mou,Shemin Lu,Wenhua Zhu,Yan Zhou
IL-22 is known to mediate inflammation in psoriasis, while IL-22 binding protein (IL-22BP) binds IL-22 to suppress IL-22 signaling. However, the function of IL-22 in regulating apoptosis in psoriasis remains poorly understood. In this study, we found that IL-22/IL-22R1 in lesional skin and IL-22 in serum from psoriatic patients were highly upregulated compared with healthy controls, while IL-22BP was
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Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells. Apoptosis (IF 4.543) Pub Date : 2020-07-05 Dimitra Aravani,Kirsty Foote,Nichola Figg,Alison Finigan,Anna Uryga,Murray Clarke,Martin Bennett
Vascular smooth muscle cells (VSMCs) are the main structural cell of blood vessels, and VSMC apoptosis occurs in vascular disease, after injury, and in vessel remodeling during development. Although VSMC apoptosis is viewed as silent, recent studies show that apoptotic cells can promote apoptosis-induced compensatory proliferation (AICP), apoptosis-induced apoptosis (AIA), and migration of both local
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Rational design of genetically encoded reporter genes for optical imaging of apoptosis. Apoptosis (IF 4.543) Pub Date : 2020-07-04 Zhijing Xu,Yingzhuang Song,Fu Wang
Apoptosis is a process in which cells are genetically regulated to cause a series of changes in morphology and metabolic activity, which ultimately lead to cell death. Apoptosis plays a vital role in the entire life cycle of an organism. Too much or too little apoptosis can cause a variety of diseases. Therefore, efficient and convenient methods for detecting apoptosis are necessary for clinical treatment
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Antiproliferative effect of bacterial cyclodipeptides in the HeLa line of human cervical cancer reveals multiple protein kinase targeting, including mTORC1/C2 complex inhibition in a TSC1/2-dependent manner. Apoptosis (IF 4.543) Pub Date : 2020-07-02 Laura Hernández-Padilla,Homero Reyes de la Cruz,Jesús Campos-García
Cervix adenocarcinoma rendered by human papillomavirus (HPV) integration is an aggressive cancer that occurs by dysregulation of multiple pathways, including oncogenes, proto-oncogenes, and tumor suppressors. The PI3K/Akt/mTOR pathway, which cross-talks with the Ras–ERK pathway, has been associated with cervical cancers (CC), which includes signaling pathways related to carcinoma aggressiveness, metastasis
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Cardiac Mitochondrial PTEN-L determines cell fate between apoptosis and survival during chronic alcohol consumption. Apoptosis (IF 4.543) Pub Date : 2020-06-26 Anusha Sivakumar,Suresh Shanmugarajan,Ramasamy Subbiah,Rekha Balakrishnan
Chronic alcohol consumption induces myocardial damage and a type of non-ischemic cardiomyopathy termed alcoholic cardiomyopathy, where mitochondrial ultrastructural damages and suppressed fusion activity promote cardiomyocyte apoptosis. The aim of the present study is to determine the role of mitochondrial fission proteins and/or other proteins that localise on cardiac mitochondria for apoptosis upon
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The α7 and β2 nicotinic acetylcholine receptor subunits regulate apoptosis in the infant hippocampus, and in sudden infant death syndrome (SIDS). Apoptosis (IF 4.543) Pub Date : 2020-06-23 L L M Luijerink,A Vivekanandarajah,K A Waters,R Machaalani
Apoptosis is increased in the hippocampus of infants who died of sudden infant death syndrome (SIDS), yet it is not known via which mechanism this has occurred. Following existing support for a role of the α7 and β2 nicotinic acetylcholine receptor (nAChR) subunits in apoptotic regulation, we aimed to determine whether these subunits are altered in the SIDS hippocampus and if they are correlated with
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The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation. Apoptosis (IF 4.543) Pub Date : 2020-06-20 Naama Maimon,Zohar Zvi Zamir,Prajakta Kalkar,Orly Zeytuni-Timor,Sagie Schif-Zuck,Sarit Larisch,Amiram Ariel
ARTS (Sept4_i2) is a pro-apoptotic protein and a product of the Sept4 gene. ARTS acts upstream of mitochondria to initiate caspase activation. ARTS induces apoptosis by specifically binding XIAP and allowing de-repression of active caspases required for Mitochondrial Outer Membrane Permeabilzation (MOMP). Moreover, ARTS promotes apoptosis by inducing ubiquitin-mediated degradation of both major anti-apoptotic
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Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins. Apoptosis (IF 4.543) Pub Date : 2020-06-12 Heinz Fischer,Erwin Tschachler,Leopold Eckhart
The release of DNA into the cytoplasm upon damage to the nucleus or during viral infection triggers an interferon-mediated defense response, inflammation and cell death. In human cells cytoplasmic DNA is sensed by cyclic GMP-AMP Synthase (cGAS) and Absent In Melanoma 2 (AIM2). Here, we report the identification of a “natural knockout” model of cGAS. Comparative genomics of phylogenetically diverse
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Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes. Apoptosis (IF 4.543) Pub Date : 2020-06-03 G Warnes
Shikonin induced necroptosis in Jurkat cells were identified flow cytometrically by the up-regulation of RIP3 in live cells and that a proportion of these cells underwent other forms of regulated cell death (RCD) which included parthanatos (< 10%), or cleaved PARP (< 10%) and DNA Damage (> 30%). Live necroptotic cells also possessed functioning mitochondria with hyper-polarized mitochondria membrane
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Combination of a p53-activating CP-31398 and an MDM2 or a FAK inhibitor produces growth suppressive effects in mesothelioma with wild-type p53 genotype. Apoptosis (IF 4.543) Pub Date : 2020-05-28 Boya Zhong,Masato Shingyoji,Michiko Hanazono,Thi Thanh Nguyễn,Takao Morinaga,Yuji Tada,Hideaki Shimada,Kenzo Hiroshima,Masatoshi Tagawa
A majority of mesothelioma had the wild-type p53 genotype but was defective of p53 functions primarily due to a genetic defect in INK4A/ARF region. We examined a growth suppressive activity of CP-31398 which was developed to restore the p53 functions irrespective of the genotype in mesothelioma with wild-type or mutated p53. CP-31398 up-regulated p53 levels in cells with wild-type p53 genotype but
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Activation of β1 integrins and caveolin-1 by TF/FVIIa promotes IGF-1R signaling and cell survival. Apoptosis (IF 4.543) Pub Date : 2020-05-27 Mikael Åberg,Desirée Edén,Agneta Siegbahn
The tissue factor/coagulation factor VIIa (TF/FVIIa) complex induces transactivation of the IGF-1 receptor (IGF-1R) in a number of different cell types. The mechanism is largely unknown. The transactivation leads to protection from apoptosis and nuclear translocation of the IGF-1R. The aim of this study was to clarify the signaling pathway between TF and IGF-1R after FVIIa treatment with PC3 and DU145
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Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic. Apoptosis (IF 4.543) Pub Date : 2020-05-21 Mark A Miles,Sarah Caruso,Amy A Baxter,Ivan K H Poon,Christine J Hawkins
Smac mimetics, or IAP antagonists, are a class of drugs currently being evaluated as anti-cancer therapeutics. These agents antagonize IAP proteins, including cIAP1/2 and XIAP, to induce cell death via apoptotic or, upon caspase-8 deficiency, necroptotic cell death pathways. Many cancer cells are unresponsive to Smac mimetic treatment as a single agent but can be sensitized to killing in the presence
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Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart. Apoptosis (IF 4.543) Pub Date : 2020-05-16 Dhananjie N K Chandrasekera,Joshua P H Neale,Isabelle van Hout,Shruti Rawal,Sean Coffey,Gregory T Jones,Richard Bunton,Ramanen Sugunesegran,Dominic Parry,Philip Davis,Patrick Manning,Michael J A Williams,Rajesh Katare
Type 2 diabetes has a strong association with the development of cardiovascular disease, which is grouped as diabetic heart disease (DHD). DHD is associated with the progressive loss of cardiovascular cells through the alteration of molecular signalling pathways associated with cell death. In this study, we sought to determine whether diabetes induces dysregulation of miR-532 and if this is associated
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Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis. Apoptosis (IF 4.543) Pub Date : 2020-05-16 Chengkui Yang,Qiao Ran,Yifei Zhou,Shan Liu,Cong Zhao,Xiaoliang Yu,Fang Zhu,Yuting Ji,Qian Du,Tao Yang,Wei Zhang,Sudan He
Smac/Diablo is a pro-apoptotic protein via interaction with inhibitors of apoptosis proteins (IAPs) to relieve their inhibition of caspases. Smac mimetic compounds (also known as antagonists of IAPs) mimic the function of Smac/Diablo and sensitize cancer cells to TNF-induced apoptosis. However, the majority of cancer cells are resistant to Smac mimetic alone. Doxorubicin is a widely used chemotherapeutic
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A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis. Apoptosis (IF 4.543) Pub Date : 2020-05-14 Zhongjie Yu,Qi Li,Yin Wang,Peifeng Li
Liver injury is the early stage of liver disease, which is caused by multiple factors. Baicalein has shown extensive bioactivity. But whether baicalein has a protective effect on liver injury has not been reported thus far. In this study, we aim to investigate the protective effects of baicalein on liver injury induced by oxidative stress. H2O2 and CCl4 were employed to establish liver injury models
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Gedunin isolated from the mangrove plant Xylocarpus granatum exerts its anti-proliferative activity in ovarian cancer cells through G2/M-phase arrest and oxidative stress-mediated intrinsic apoptosis. Apoptosis (IF 4.543) Pub Date : 2020-05-13 Rohit Sahai,Arindam Bhattacharjee,Vishwa Nath Shukla,Pragya Yadav,Mohammad Hasanain,Jayanta Sarkar,T Narender,Kalyan Mitra
Gedunin is a natural tetranorterpenoid secondary metabolite found in plants of the Meliaceae family, which has been reported for its antiparasitic, antifungal and anticancer activities. Here, we describe the molecular mechanisms underlying the in vitro anti proliferative activity of gedunin (isolated from the mangrove plant Xylocarpus granatum) in human ovarian cancer cells. We observed that gedunin
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Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis. Apoptosis (IF 4.543) Pub Date : 2020-05-13 Magdalena Markowicz-Piasecka,Johanna Huttunen,Ahmed Montaser,Kristiina M Huttunen
Increased amounts of amino acids are essential for cancer cells to support their sustained growth and survival. Therefore, inhibitors of amino acid transporters, such as L-type amino acid transporter 1 (LAT1) have been developed. In this study, a previously reported LAT1-inhibitor (KMH-233) was studied for its hemocompatibility and toxicity towards human umbilical vein endothelial cells (HUVEC) and
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Citarinostat and Momelotinib co-target HDAC6 and JAK2/STAT3 in lymphoid malignant cell lines: a potential new therapeutic combination. Apoptosis (IF 4.543) Pub Date : 2020-05-11 Maria Cosenza,Monica Civallero,Luigi Marcheselli,Stefano Sacchi,Samantha Pozzi
Histone deacetylase (HDAC) inhibitors represent an encouraging class of antitumor drugs. HDAC inhibitors induce a series of molecular and biological responses and minimal toxicity to normal cells. Citarinostat (Acy-241) is a second generation, orally administered, HDAC6-selective inhibitor. Momelotinib (CYT387) is an orally administered inhibitor of Janus kinase/signal transducer of transcription-3
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The function of RNase L and its degradation mechanism in cardiac acute ischemic injury. Apoptosis (IF 4.543) Pub Date : 2020-05-08 Qiang Ma,Jingwei Li,Hao Zhou,Wei Tong,Yundai Chen
RNase L is generally thought to play a key role in antiviral defenses. Although RNase L protein and mRNA are known to be highly expressed in myocardial tissue, there are few studies of the potential functions of RNase L in myocardial tissue. In this study, we tested the hypothesis that RNase L may be involved in the pathological process of cardiac ischemic injury. RNase L-overexpressing and RNase L
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Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats. Apoptosis (IF 4.543) Pub Date : 2020-04-27 Wei-Han Li,Ying-Lin Yang,Xiao Cheng,Man Liu,Shan-Shan Zhang,Yue-Hua Wang,Guan-Hua Du
It is reported that baicalein can activate PI3K/AKT pathway, inhibit caspase activation and reduce cerebral infarct volume in middle cerebral artery occlusion (MCAO) rats. However, a caspase-independent mechanism initiated by poly (ADP-ribose) polymerase-1 (PARP-1) activation has been reported to make more contribution to cells death after ischemic stroke. In the present study, we established a cerebral
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BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy. Apoptosis (IF 4.543) Pub Date : 2020-04-25 Prashanthi Ramesh,Jan Paul Medema
Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-regulation of the balance between proliferation and apoptosis contributes to tumor initiation. Particularly in the colon where apoptosis is a crucial process in intestinal turnover, inhibition of apoptosis facilitates transformation and tumor progression. The BCL-2 family of proteins are key regulators of apoptosis
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Soluble receptor for advanced glycation end-products promotes angiogenesis through activation of STAT3 in myocardial ischemia/reperfusion injury. Apoptosis (IF 4.543) Pub Date : 2020-04-24 Xianxian Cao,Bin Li,Xuejie Han,Xiuling Zhang,Mengqiu Dang,Hongxia Wang,Fenghe Du,Xiangjun Zeng,Caixia Guo
Soluble receptor for advanced glycation end-products (sRAGE), which exerts cardioprotective effect through inhibiting cardiomyocyte apoptosis and autophagy during ischemia/reperfusion (I/R) injury, is also known to enhance angiogenesis in post-ischemic reperfusion injury-critical limb ischemia (PIRI-CLI) mice. However, whether sRAGE protects the heart from myocardial I/R injury via promoting angiogenesis
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Artemisinin and dihydroartemisinin promote β-cell apoptosis induced by palmitate via enhancing ER stress. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Ke Chen,Hu Hua,Ziyang Zhu,Tong Wu,Zhanjun Jia,Qianqi Liu
Artemisinin (ART) and dihydroartemisinin (DHA) are first-line antimalarial drugs and have been reported to have anti-obesity effects. Hyperlipidemia is associated with β-cell damage in obese subjects, which could contribute to the pathogenesis of type 2 diabetes. In addition to their anti-obesity effects, ART and DHA also have protective roles in some diseases. Thus, we investigated the effects of
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microRNA-499a promotes the progression and chemoresistance of cervical cancer cells by targeting SOX6. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Yibing Chen,Yucen Song,Yanjun Mi,Huan Jin,Jun Cao,Haolong Li,Liping Han,Ting Huang,Xiaofei Zhang,Shumin Ren,Qian Ma,Zhengzhi Zou
Emerging evidence has indicated that microRNAs are involved in multiple processes of cancer development. Previous studies have demonstrated that microRNA-499a (miR-499a) plays both oncogenic and tumor suppressive roles in several types of malignancies, and genetic variants in miR-499a are associated with the risk of cervical cancer. However, the biological roles of miR-499a in cervical cancer have
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Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Lindsey M Ludwig,Lauren E Roach,Samuel G Katz,James L LaBelle
BIM is the master BH3-only BCL-2 family regulator of lymphocyte survival. To understand how long-term loss of BIM affects apoptotic resistance in T cells we studied animals with T cell-specific deletion of Bim. Unlike CD19CREBimfl/fl animals, LCKCREBimfl/fl mice have pronounced early lymphocytosis followed by normalization of lymphocyte counts over time. This normalization occurred in mature T cells
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Necroptosis and its role in infectious diseases. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Xiaojing Xia,Liancheng Lei,Song Wang,Jianhe Hu,Gaiping Zhang
Necroptosis is a noncaspase-dependent and precisely regulated mechanism of cell death. Necroptosis is mainly initiated by members of the tumor necrosis factor receptor (TNFR) and Toll-like receptor (TLR) families, interferon, intracellular RNA and DNA sensors and other mediators. Subsequently, the protein kinase RIPK1 (receptor-interacting protein kinase 1) and RIPK3 interact with the receptor protein
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DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Omprakash Shriwas,Manashi Priyadarshini,Sabindra K Samal,Rachna Rath,Sanjay Panda,Saroj Kumar Das Majumdar,Dillip Kumar Muduly,Mahendran Botlagunta,Rupesh Dash
Platinum based drugs alone or in combination with 5FU and docetaxel are common regimen chemotherapeutics for the treatment of advanced OSCC. Chemoresistance is one of the major factors of treatment failure in OSCC. Human RNA helicase DDX3 plays an important role in cell proliferation, invasion, and metastasis in several neoplasms. The potential role of DDX3 in chemoresistance is yet to be explored
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miR-21 protects neonatal rats from hypoxic-ischemic brain damage by targeting CCL3. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Jiangtao Liu,Sai Zhang,Yuanyuan Huang,Liqun Sun
Hypoxic-ischemic brain damage (HIBD) represents one of the leading causes of neonatal mortality and permanent neurological disability worldwide. Compelling studies have identified implication of microRNAs (miRNAs) in HIBD. However, the molecular mechanism of miR-21 underlying the disease pathogenesis is unknown. The present study aims to explore the role of miR-21 in neonatal rats with HIBD. HIBD rat
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Glucocorticoid-induced autophagy and apoptosis in bone. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Tiantian Wang,Xiaonan Liu,Chengqi He
Glucocorticoids are widely prescribed to treat various allergic and autoimmune diseases; however, long-term use results in glucocorticoid-induced osteoporosis, characterized by consistent changes in bone remodeling with decreased bone formation as well as increased bone resorption. Not only bone mass but also bone quality decrease, resulting in an increased incidence of fractures. The primary role
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Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Chen Luo,Qilin Huang,Xiaohui Yuan,Yi Yang,Bing Wang,Zhu Huang,Lijun Tang,Hongyu Sun
Our previous studies have shown that abdominal paracentesis drainage (APD) is a safe and effective strategy for patients with severe acute pancreatitis (SAP). However, the underlying mechanisms behind APD treatment remain poorly understood. Given that apoptosis is a critical pathological response of SAP, we here aim to investigate the effect of APD on cell apoptosis in pancreatic tissues during SAP
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BRAFi induced demethylation of miR-152-5p regulates phenotype switching by targeting TXNIP in cutaneous melanoma. Apoptosis (IF 4.543) Pub Date : 2020-04-01 Kezhu Li,Mingrui Tang,Shuang Tong,Chenchao Wang,Qiang Sun,Mengzhu Lv,Xu Sun,Ting Wang,Shifeng Jin
Treatment of advanced BRAFV600-mutant melanoma using BRAF inhibitors (BRAFi) eventually leads to drug resistance and selects for highly metastatic tumor cells. We compared the most differentially dysregulated miRNA expression profiles of vemurafenib-resistant and highly-metastatic melanoma cell lines obtained from GEO DataSets. We discovered miR-152-5p was a potential regulator mediating melanoma drug
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Exploitation of a novel phenothiazine derivative for its anti-cancer activities in malignant glioblastoma. Apoptosis (IF 4.543) Pub Date : 2020-04-01 S I Omoruyi,O E Ekpo,D M Semenya,A Jardine,S Prince
Glioblastoma remains the most malignant of all primary adult brain tumours with poor patient survival and limited treatment options. This study adopts a drug repurposing approach by investigating the anti-cancer activity of a derivative of the antipsychotic drug phenothiazine (DS00329) in malignant U251 and U87 glioblastoma cells. Results from MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
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Correction to: M1 macrophage dependent-p53 regulates the intracellular survival of mycobacteria. Apoptosis (IF 4.543) Pub Date : 2019-11-27 Yun-Ji Lim,Junghwan Lee,Ji-Ae Choi,Soo-Na Cho,Sang-Hun Son,Sun-Jung Kwon,Ji-Woong Son,Chang-Hwa Song
The original version of this article unfortunately contains an error in the acknowledgement section. The text "Brain Korea 21 PLUS Project for Medical Science, Chungnam National University" was omitted by mistake. The correct and complete acknowledgment is given below: Acknowledgments This work was supported by the research fund of Chungnam National University and the Brain Korea 21 PLUS Project for
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MicroRNA-214 targets COX-2 to antagonize indoxyl sulfate (IS)-induced endothelial cell apoptosis Apoptosis (IF 4.543) Pub Date : 2019-12-09