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Dual Control of Host Actin Polymerization by a Legionella Effector Pair Cell. Microbiol. (IF 3.4) Pub Date : 2024-1-27 M. Pillon, C. Michard, N. Baïlo, J. Bougnon, K. Picq, O. Dubois, C. Andrea, L. Attaiech, V. Daubin, S. Jarraud, E. Kay, P. Doublet
Host actin cytoskeleton is often targeted by pathogenic bacteria through the secretion of effectors. Legionella pneumophila virulence relies on the injection of the largest known arsenal of bacterial proteins, over 300 Dot/Icm type 4 secretion system effectors, into the host cytosol. Here, we define the functional interactions between VipA and LegK2, two effectors with antagonistic activities towards
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Molecular Docking, Dynamics Simulations, ADMET, and DFT Calculations: Combined In Silico Approach to Screen Natural Inhibitors of 3CL and PL Proteases of SARS-CoV-2 Cell. Microbiol. (IF 3.4) Pub Date : 2024-1-16 Sugumar Mohanasundaram, Porkodi Karthikeyan, Venkatesan Sampath, M. Anbazhagan, Sundramurthy Venkatesa Prabhu, Jamal M. Khaled, Muthu Thiruvengadam
Considering natural compounds for the antiviral effect is another opportunity for exploring novel drug candidates for severe acute respiratory syndrome coronavirus 2. The selected natural compounds were interacted using a molecular docking approach. The 3D structures of the main protease and papain-like protease were used for the virtual screening to detect the potent inhibitor against SARS-CoV-2.
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Differences in Rhizosphere Microbial Community Structure and Composition in Resistance and Susceptible Wheat to Fusarium Head Blight Cell. Microbiol. (IF 3.4) Pub Date : 2023-10-31 Han Li, Mingshuang Tang, Tao Zheng, Ming Yang, Youning Wang, Yating Shuai, Yan Li, Yibo Zhang, Dongfang Ma
Fusarium head blight (FHB) is a serious disease of wheat that threatens wheat production worldwide. In this study, high-throughput sequencing technology was used to analyze the rhizosphere soil microbial metagenomes of 4 wheat cultivars with different levels of resistance to FHB. The results showed that there were differences in the diversity, structure, and composition of rhizosphere microorganisms
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Commonality of Virulence-Promoting Function in Rhodococcus equi Virulence Associated Proteins (Vaps) Cell. Microbiol. (IF 3.4) Pub Date : 2023-10-10 Timothy R. Ganderton, Daniel Ghete, Karen Hogg, Graeme J. Park, Christoph G. Baumann, Anthony J. Wilkinson, Paul R. Pryor
Rhodococcus equi is a Gram-positive facultative intracellular pathogen associated with life-threatening bronchopneumonial disease in foals. Key to R. equi’s intracellular survival in host macrophages is the production of virulence associated proteins (Vaps). Numerous vap genes are found on virulence plasmids isolated from different species, and the Vaps share a high degree of sequence identity. VapA
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Analysis of Specific Allergens in the Serum of Patients with Allergic Diseases in the Shanxi Region of China Cell. Microbiol. (IF 3.4) Pub Date : 2023-5-4 Jing Wu, Yuee Liu, Min Xie, Yanzhi Cui, Yaona Wei, Yan Cheng, Jing Yang, Hongxia Zhang, Lei Wang
The aim of this study is to analyze the distribution characteristics of specific allergens based on the immunoglobulin E (IgE) test, performed using the sera of patients with allergic diseases in the Shanxi region of China. Sera from 3141 patients with allergic diseases were analyzed with immunoblotting for IgE antibodies specific to inhaled and ingested allergens. The distribution of allergens and
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Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases Cell. Microbiol. (IF 3.4) Pub Date : 2023-4-25 Yurong Zhang, Dianlun Qian, Xiangfeng Bai, Shibo Sun
Ferroptosis is a new type of iron-dependent cell death caused by lipid peroxide (LPO) accumulation and involved in disease of pulmonary infection. The dysregulation of iron metabolism, the accumulation of LPO, and the inactivation and consumption of glutathione peroxidase 4 (GPX4) are the crucial cause of ferroptosis. Pulmonary infectious diseases caused by Pseudomonas aeruginosa (PA), Mycobacterium
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G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells Cell. Microbiol. (IF 3.4) Pub Date : 2023-3-28 Matthew Vassey, Rininta Firdaus, Akhmed Aslam, Lee M. Wheldon, Neil J. Oldfield, Dlawer A. A. Ala’Aldeen, Karl G. Wooldridge
Neisseria meningitidis is the most frequent cause of bacterial meningitis and is one of the few bacterial pathogens that can breach the blood-brain barrier (BBB). The 37/67 kDa laminin receptor (LamR) was previously identified as a receptor mediating meningococcal binding to rodent and human brain microvascular endothelial cells, which form part of the BBB. The meningococcal surface proteins PorA and
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Akkermansia muciniphila Ameliorates Lung Injury in Smoke-Induced COPD Mice by IL-17 and Autophagy Cell. Microbiol. (IF 3.4) Pub Date : 2023-3-15 Li Zhang, Junjuan Lu, Caihong Liu
Objective. Smoking is a primary hazard factor for chronic obstructive pulmonary disease (COPD), which induced a decrease in intestinal Akkermansia muciniphila abundance and Th17 imbalance in COPD. This study analyzed the changes of gut microbiota metabolism and Akkermansia abundance in patients with smoking-related COPD and explored the potential function of Akkermansia muciniphila in smoke-induced
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Knockout of Noxa with CRISPR/Cas9 Increases Host Resistance to Influenza Virus Infection Cell. Microbiol. (IF 3.4) Pub Date : 2023-2-16 Ao Zhou, Wenhua Zhang, Baoxin Wang, Xia Dong, Jing Zhang, Hongbo Chen
The influenza virus induces cellular apoptosis during viral propagation, and controlling this virus-induced apoptosis process has been shown to have significant antiviral effects. The proapoptotic BH3-only protein Noxa is a strong inducer of apoptosis that can be activated by this virus, suggesting that Noxa has the potential as an anti-influenza target. To assess the value of Noxa as an antiviral
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Mycobacterium avium Infection of Multinucleated Giant Cells Reveals Association of Bacterial Survival to Autophagy and Cholesterol Utilization Cell. Microbiol. (IF 3.4) Pub Date : 2023-2-11 Jayanthi J. Joseph, Amy Leestemaker-Palmer, Soheila Kazemi, Lia Danelishvili, Luiz E. Bermudez
Mycobacterium avium subsp. hominissuis (M. avium) is an opportunistic environmental pathogen that typically infects patients with existing lung conditions such as cystic fibrosis or COPD. Pulmonary M. avium infection generates peribronchial granulomas that contain infected macrophages and multinucleated giant cells (MGCs). While granuloma formation with MGCs is a common feature of mycobacterial infection
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Kluyveromyces marxianus Ameliorates High-Fat-Diet-Induced Kidney Injury by Affecting Gut Microbiota and TLR4/NF-κB Pathway in a Mouse Model Cell. Microbiol. (IF 3.4) Pub Date : 2023-2-8 Na Li, Guanjie Zhao, Mingzhu Xu
Objectives. The effects of Kluyveromyces marxianus on high-fat diet- (HFD-) induced kidney injury (KI) were explored. Methods. HFD-induced KI model was established using male C57BL/6 mice and treated with K. marxianus JLU-1016 and acid-resistant (AR) strain JLU-1016A. Glucose tolerance was evaluated via an oral glucose tolerance test (OGTT). KI was measured using Hematoxylin and Eosin (H&E) staining
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Shionone Relieves Urinary Tract Infections by Removing Bacteria from Bladder Epithelial Cells Cell. Microbiol. (IF 3.4) Pub Date : 2023-2-3 Hao Yin, Jiaoli Zhu, Yi Jiang, Yijing Mao, Chenquan Tang, Hui Cao, Yufang Huang, Huijun Zhu, Jianping Luo, Qingjiang Jin, Qinglei Jin, Yi Xue, Xin Wang
In clinical practice, urinary tract infections (UTIs) are second only to respiratory infections in terms of infectious diseases. In recent years, drug resistance of Escherichia coli (E. coli) has increased significantly. The therapeutic effects of Shionone on UTI were assessed by modelling UTI in SD rats and SV-HUC-1 cells with E. coli solution. After treatment of Shionone, the UTI rat model showed
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Liver Microbiome in Healthy Rats: The Hidden Inhabitants of Hepatocytes Cell. Microbiol. (IF 3.4) Pub Date : 2023-1-31 Xiao Wei Sun, Hua Zhang, Xiao Zhang, Peng Fei Xin, Xue Gao, Hong Rui Li, Cai Yun Zhou, Wen Min Gao, Xuan Xuan Kou, Jian Gang Zhang
The tumor and tissue microbiota of human beings have recently been investigated. Gut permeability is known as a possible resource for the positive detection of tissue bacteria. Herein, we report that microbiota were detected in high abundance in the hepatocytes of healthy rats and that they were shared with the gut microbiota to an extent. We assessed male Sprague Dawley (SD) rats for the 16S ribosomal
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Campylobacter jejuni Modulates Reactive Oxygen Species Production and NADPH Oxidase 1 Expression in Human Intestinal Epithelial Cells Cell. Microbiol. (IF 3.4) Pub Date : 2023-1-30 Geunhye Hong, Cadi Davies, Zahra Omole, Janie Liaw, Anna D. Grabowska, Barbara Canonico, Nicolae Corcionivoschi, Brendan W. Wren, Nick Dorrell, Abdi Elmi, Ozan Gundogdu
Campylobacter jejuni is the major bacterial cause of foodborne gastroenteritis worldwide. Mechanistically, how this pathogen interacts with intrinsic defence machinery of human intestinal epithelial cells (IECs) remains elusive. To address this, we investigated how C. jejuni counteracts the intracellular and extracellular reactive oxygen species (ROS) in IECs. Our work shows that C. jejuni differentially
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Fecal Microbiome Does Not Represent Whole Gut Microbiome Cell. Microbiol. (IF 3.4) Pub Date : 2023-1-17 Ji-Seon Ahn, Enkhchimeg Lkhagva, Sunjun Jung, Hyeon-Jin Kim, Hea-Jong Chung, Seong-Tshool Hong
The current gut microbiome research relies on the fecal microbiome under the assumption that the fecal microbiome represents the microbiome of the entire gastrointestinal (GI) tract. However, there have been growing concerns about using feces as a proxy to study the gut microbiome. Here, we comprehensively analyzed the composition of microbiome and metabolites in the feces and at 14 different locations
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Application of Bioinformatics Tools for the Prediction of Helper MicroRNAs for Improvement of Oncolytic Virus Efficacy Cell. Microbiol. (IF 3.4) Pub Date : 2022-12-29 Nasrin Rastegarvand, Hoorieh Soleimanjahi, Ehsan Arefian, Mahmoud Reza Pourkarim
Purpose. Oncolytic Reoviruses, as a self-limiting virus, can be used in cancer treatment, because they have the ability to replicate in tumor cells selectively and destroy them. Studies show that some immune response proteins may interfere with the virus life cycle. So, the main aim of this bioinformatic study is to check which microRNA is able to target some reovirus inhibitory proteins. Experimental
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Status of COVID-19 Infection and Vaccination in People Aged 18 Years and over in a Town: A Cross-Sectional Study in Turkey Cell. Microbiol. (IF 3.4) Pub Date : 2022-12-16 Volkan Medeni, Irem Medeni
Objective. The objective of this study was to evaluate the cases of COVID-19 infection in people >18 years old and to investigate attitudes against vaccination and vaccine hesitancy and the factors affecting them. Methods. The data collection form used in the study was prepared by the researchers by screening the relevant literature. People over the age of 18 who agreed to participate in the study
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Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway Cell. Microbiol. (IF 3.4) Pub Date : 2022-11-16 Jiahui An, Chao Zhang, Jinshuang Cai, Yufeng Li
Coinfections of porcine circovirus type 2 (PCV2) and Glaesserella parasuis (G. parasuis) are widely existing in the swine industry worldwide. However, the mechanisms for this coinfection remain unclear. The aim of this study is to assess whether the coinfection PCV2 and G. parasuis would affect the inflammatory response and related mechanisms. In this study, BALB/c mice and RAW264.7 cells were used
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Deletion of a Putative GPI-Anchored Protein-Encoding Gene Aog185 Impedes the Growth and Nematode-Trapping Efficiency of Arthrobotrys oligospora by Disrupting Transmembrane Transport Homeostasis Cell. Microbiol. (IF 3.4) Pub Date : 2022-11-14 Hui Peng, Hengqian Lu, Xinyuan Dong, Xiao Liang, Kangliang Sheng, Jingmin Wang, Xiaowei Kong, Xiangdong Zha, Yongzhong Wang
Nematode-trapping fungus (NTF) is a crucial predator of nematodes, which can capture nematodes by developing specific trapping devices. However, there is limited understanding of the role and mechanism of cell surface proteins attached to the surface of mycelia or trapping cells. Here, the effects of a putative GPI-anchored protein-encoding gene Aog185 on the growth and nematode-trapping efficiency
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Similarities and Differences among Species Closely Related to Candida albicans: C. tropicalis, C. dubliniensis, and C. auris Cell. Microbiol. (IF 3.4) Pub Date : 2022-11-9 Dorota Satala, Magdalena Juszczak, Ewelina Wronowska, Magdalena Surowiec, Kamila Kulig, Andrzej Kozik, Maria Rapala-Kozik, Justyna Karkowska-Kuleta
Although Candida species are widespread commensals of the microflora of healthy individuals, they are also among the most important human fungal pathogens that under certain conditions can cause diseases (candidiases) of varying severity ranging from mild superficial infections of the mucous membranes to life-threatening systemic infections. So far, the vast majority of research aimed at understanding
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Biomolecules of the Horseshoe Crab’s Hemolymph: Components of an Ancient Defensive Mechanism and Its Impact on the Pharmaceutical and Biomedical Industry Cell. Microbiol. (IF 3.4) Pub Date : 2022-10-27 Md. Ashrafuzzaman, Mamudul Hasan Razu, Nazmir-Nur Showva, Tohmina Afroze Bondhon, Md. Moniruzzaman, Sad Al Rezwan Rahman, Md. Raisul Islam Rabby, Fatema Akter, Mala Khan
Without adaptive immunity, invertebrates have evolved innate immune systems that react to antigens on the surfaces of pathogens. These defense mechanisms are included in horseshoe crab hemocytes’ cellular responses to pathogens. Secretory granules, large (L) and small (S), are found on hemocytes. Once the invasion of pathogens is present, these granules release their contents through exocytosis. Recent
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Pasteurella multocida Toxin Aggravates Ligatured-Induced Periodontal Bone Loss and Inflammation via NOD-Like Receptor Protein 3 Inflammasome Cell. Microbiol. (IF 3.4) Pub Date : 2022-10-4 Yineng Han, Pengfei Gao, Qiaolin Yang, Yiping Huang, Lingfei Jia, Yunfei Zheng, Weiran Li
NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is reportedly involved in periodontal pathogenesis. Pasteurella multocida toxin (PMT) is the major virulence factor of Pasteurella multocida strains, which belongs to the nonoral gram-negative facultative rods (GNFR). The existence of GNFR and their toxin may aggravate periodontitis. Therefore, it is important to unclose the regulatory
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Correlation between HPV PCNA, p16, and p21 Expression in Lung Cancer Patients Cell. Microbiol. (IF 3.4) Pub Date : 2022-9-28 B. F. São Marcos, T. H. A. de Oliveira, C. M. M. Do Amaral, M. T. C. Muniz, A. C. Freitas
Purpose. Evaluate if human papillomavirus (HPV) infection in lung cancer patients might be helping cancer development by altering p16, p21, and PCNA, key human genes involved in cell proliferation and tumor development. Methods. 63 fresh-frozen (FF) and formalin-fixed paraffin-embedded (FFPE) samples from lung tumor patients were used to detect HPV by PCR, followed by genotype through sequencing. The
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Dynamics of DNA Replication during Male Gametogenesis in the Malaria Parasite Plasmodium Falciparum Cell. Microbiol. (IF 3.4) Pub Date : 2022-08-29 Holly Matthews, Jennifer McDonald, Francis Isidore G. Totañes, Catherine J. Merrick
Malaria parasites undergo a single phase of sexual reproduction in their complex lifecycle. It involves specialised, sexually committed cells called gametocytes, which develop rapidly into mature gametes and mate upon entering the mosquito midgut. Gamete development is unique, involving unprecedentedly fast replication to produce male gametes. Within ~15 minutes a male gametocyte replicates its ~23 Mb
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Molecular Modeling Guided Drug Designing for the Therapeutic Treatment of Rheumatoid Arthritis Cell. Microbiol. (IF 3.4) Pub Date : 2022-08-27 Maheen Imran, Muhammad Hassan Nasir, Syed Awais Attique, Atif Amin Baig, Qurat Ul Ain, Muhammad Usman, Muzna Munir, Hassaan Anwer Rathore
Rheumatoid arthritis (RA) is a systemic inflammatory disorder that can cause destructive joint disease, significant disability, and increased mortality. RA is the most frequent of all chronic inflammatory joint diseases, and its prevalence frequency in Pakistan is 1.6 per thousand people. Different cytokines and receptors were involved in the triggering of RA, including interleukin-6 (ILR-6), major
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A Model of Intracellular Persistence of Pseudomonas aeruginosa in Airway Epithelial Cells Cell. Microbiol. (IF 3.4) Pub Date : 2022-08-12 Julien K. Malet, Lisa C. Hennemann, Elizabeth M.-L. Hua, Emmanuel Faure, Valerie Waters, Simon Rousseau, Dao Nguyen
Pseudomonas aeruginosa (P.a.) is a major human pathogen capable of causing chronic infections in hosts with weakened barrier functions and host defenses, most notably airway infections commonly observed in individuals with the genetic disorder cystic fibrosis (CF). While mainly described as an extracellular pathogen, previous in vitro studies have described the molecular events leading to P.a. internalization
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“The Good, the Bad and the Ugly”: Interplay of Innate Immunity and Inflammation Cell. Microbiol. (IF 3.4) Pub Date : 2022-08-10 Mercedes Alemán
Innate immunity recognizes microorganisms through certain invariant receptors named pattern recognition receptors (PRRs) by sensing conserved pathogen-associated molecular patterns (PAMPs). Their recognition activates several signaling pathways that lead the transcription of inflammatory mediators, contributing to trigger a very rapid inflammatory cascade aiming to contain the local infection as well
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ApiAP2 Gene-Network Regulates Gametocytogenesis in Plasmodium Parasites Cell. Microbiol. (IF 3.4) Pub Date : 2022-07-19 Elvis Quansah, Faustina Pappoe, Jilong Shen, Miao Liu, Shijie Yang, Li Yu, Chao Zhang
Malaria is a mosquito-borne infectious disease, caused by unicellular Apicomplexan protozoa of the genus Plasmodium. The sexual stage of Plasmodium is one of the most fascinating aspects of the Plasmodium life cycle, yet relatively less explored until now. The production of sexually fit gametocytes through gametocytogenesis is essential to the transmission of the Plasmodium parasite into an anopheline
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Study on Analysis of Several Molecular Identification Methods for Ciliates of Colpodea (Protista, Ciliophora) Cell. Microbiol. (IF 3.4) Pub Date : 2022-06-28 Yumeng Song, Tingting Hao, Bailin Li, Weibin Zheng, Lihui Liu, Li Wang, Ying Chen, Xuming Pan
The application of molecular techniques to accurately identify protozoan species can correct previous misidentifications based on traditional morphological identification. Colpodea ciliates have many toxicological and cytological applications, but their subtle morphological differences and small body size hinder species delineation. Herein, we used Cox I and β-tubulin genes, alongside fluorescence
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Phagosomal Acidification Is Required to Kill Streptococcus pneumoniae in a Zebrafish Model Cell. Microbiol. (IF 3.4) Pub Date : 2022-06-09 Tomasz K. Prajsnar, Bartosz J. Michno, Niedharsan Pooranachandran, Andrew K. Fenton, Tim J. Mitchell, David H. Dockrell, Stephen A. Renshaw
Streptococcus pneumoniae (the pneumococcus) is a major human pathogen causing invasive disease, including community-acquired bacteraemia, and remains a leading cause of global mortality. Understanding the role of phagocytes in killing bacteria is still limited, especially in vivo. In this study, we established a zebrafish model to study the interaction between intravenously administered pneumococci
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Inhibition of Homeobox D10 Alleviates Acute Kidney Injury by Upregulating PI3K/AKT Signaling Proteins Cell. Microbiol. (IF 3.4) Pub Date : 2022-06-01 Siqi Liu, Huixin Sun, Jingjie Guo, Linlin Ma
Purpose. To observe the protective effect of homeobox D10 (HOXD10) on acute kidney injury (AKI) by regulating PI3K/AKT signaling pathway is the purpose of this study.Methods. 30 rats were randomly divided into three groups: blank control group, model group, and HOXD10 interference group. The kidney function indexes, HOXD10 protein expression, histopathological features, tubulointerstitial injury, and
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Guanylate-Binding Protein 1 Regulates Infection-Induced Autophagy through TBK1 Phosphorylation Cell. Microbiol. (IF 3.4) Pub Date : 2022-05-29 Miyako Hikichi, Hirotaka Toh, Atsuko Minowa-Nozawa, Takashi Nozawa, Ichiro Nakagawa
Invading bacteria can be degraded by selective autophagy, known as xenophagy. Recent studies have shown that the recruitment of autophagy adaptor proteins such as p62 to bacteria and its regulation by activated TANK-binding kinase 1 (TBK1) are required to overcome bacterial infection. However, the detailed molecular mechanisms behind this are not yet fully understood. Here, we show that the human guanylate-binding
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Mathematical Analysis of the Healthcare Treatment of 215 Patients with Coronary Heart Disease Cell. Microbiol. (IF 3.4) Pub Date : 2022-05-24 Meiyi Tao, Shengli Sun, Yuelan Qin, Juan Wu, Yimin Cai, Dandan Li, Ke Tang, Ling Li, Shuang Wu
The main risk factors for CHD and the comorbidity include hyperlipidemia (HL), hypertension, smoking, dietary factors, and genetic factors. In this work, 215 patients with coronary heart disease, including 128 males and 87 females, were analyzed for a better understanding of the related clinical pharmacology. Nonparametric test, analysis of variance, chi-square test, correlation analysis, and other
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Symbiosis with Dinoflagellates Alters Cnidarian Cell-Cycle Gene Expression Cell. Microbiol. (IF 3.4) Pub Date : 2022-05-23 Lucy M. Gorman, Migle K. Konciute, Guoxin Cui, Clinton A. Oakley, Arthur R. Grossman, Virginia M. Weis, Manuel Aranda, Simon K. Davy
In the cnidarian-dinoflagellate symbiosis, hosts show altered expression of genes involved in growth and proliferation when in the symbiotic state, but little is known about the molecular mechanisms that underlie the host’s altered growth rate. Using tissue-specific transcriptomics, we determined how symbiosis affects expression of cell cycle-associated genes, in the model symbiotic cnidarian Exaiptasia
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LncRNA LINC01116 Regulates the Proliferation, Migration, and Invasion of Cervical Cancer Cells by Targeting miR-744-5p Cell. Microbiol. (IF 3.4) Pub Date : 2022-05-21 Jing Wang, Lei Yue, Ye Shen
Objective. To investigate the effects and potential molecular mechanisms of LncRNA LINC01116 on proliferation, migration, and invasion of cervical cancer cells. Method(s). The content of miR-744-5p and LINC01116 in cervical cancer cells HeLa, SiHa, and C33a was detected by RT-PCR, the proliferative activity and clone number of SiHa cells were determined by MTT and clone formation assay, the number
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Analysis of Gastric Diseases and Their Symptoms Based on Indexes of Pepsinogen I (PGI) and Pepsinogen II (PGII): Take 1106 Patients as Samples Cell. Microbiol. (IF 3.4) Pub Date : 2022-05-17 Kuanpeng Guo, Zhengqiu Li, Bibo Qiu, Bin Hu, Suwu Yi
In this study, preoperative analysis of 1106 gastropathy patients with abdominal pain, vomiting, dyspepsia, and other symptoms was conducted. Independent sample -test and correlation analysis and other ways were used for data cleansing and analysis. Findings were as follows: (1) Samples of different genders showed significance in PGI and PGII. The PGI and PGII values of women were significantly lower
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Analysis of Effects of PTEN-Mediated TGF-β/Smad2 Pathway on Osteogenic Differentiation in Osteoporotic Tibial Fracture Rats and Bone Marrow Mesenchymal Stem Cell under Tension Cell. Microbiol. (IF 3.4) Pub Date : 2022-04-29 Shiyong Ling, Chen Yan, Kai Huang, Bo Lv, Hua Wang, Xiaoyan Wang, Jun Chen, Jingchuan Sun
Purpose. To discuss effects of phosphatase and tensin homolog protein (PTEN)-mediated transforming growth factor-β (TGF-β)/Smad homologue 2 (Smad2) pathway on osteogenic differentiation in osteoporotic (OP) tibial fracture rats and bone marrow mesenchymal stem cell (BMSC) under tension. Methods. A tibial fracture model was established. The rats were divided into sham-operated group and model group
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Study on the Antifatigue Effect of Compound Amino Acid Capsules Cell. Microbiol. (IF 3.4) Pub Date : 2022-04-27 Wen Huang, Huaqiang Hui, Jiping Xu, Honglei Guo, Yunfeng Wang, Wei Zhu
Supplementing amino acids was proven to relieve fatigue caused by exercise. This study explored the antifatigue effects of compound amino acid capsules (CAAC) on rats undergoing the forced swimming test (FST). CAAC augmented the endurance of FST in rats and alleviated the damage of skeletal muscle tissue and reduced the content of biochemical indicators in the serum. Furthermore, CAAC prevented skeletal
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Chlamydia pneumoniae Interferes with Macrophage Differentiation and Cell Cycle Regulation to Promote Its Replication Cell. Microbiol. (IF 3.4) Pub Date : 2022-04-11 Eveliina Taavitsainen-Wahlroos, Ilkka Miettinen, Maarit Ylätalo, Inés Reigada, Kirsi Savijoki, Tuula Anneli Nyman, Leena Hanski
Chlamydia pneumoniae is a ubiquitous intracellular bacterium which infects humans via the respiratory route. The tendency of C. pneumoniae to persist in monocytes and macrophages is well known, but the underlying host-chlamydial interactions remain elusive. In this work, we have described changes in macrophage intracellular signaling pathways induced by C. pneumoniae infection. Label-free quantitative
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Bacterial Atlas of Mouse Gut Microbiota Cell. Microbiol. (IF 3.4) Pub Date : 2022-04-11 Mengqi Chu, Xiaobo Zhang
Background. Mouse model is one of the most widely used animal models for exploring the roles of human gut microbiota, a complex system involving in human immunity and metabolism. However, the structure of mouse gut bacterial community has not been explored at a large scale. To address this concern, the diversity and composition of the gut bacteria of 600 mice were characterized in this study. Results
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miR-30c Increases the Intracellular Survival of Helicobacter pylori by Inhibiting Autophagy Cell. Microbiol. (IF 3.4) Pub Date : 2022-03-24 Qiuhua Deng, Yifei Xu, Yuanzun Zhong, Liyao Tang, Si Du, Jiongming Yang, Lingping Wu, Shaoju Guo, Bin Huang, Hongying Cao, Ping Huang
Persistent Helicobacter pylori infection causes a variety of gastrointestinal diseases and even gastric cancer. H. pylori invades gastric epithelial cells to survive and proliferate, which is one of the key factors in persistent colonization. A Published study has confirmed that cells can eliminate intracellular H. pylori through xenophagy to maintain intracellular balance. However, a growing body
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Plasmodium berghei-Mediated NRF2 Activation in Infected Hepatocytes Enhances Parasite Survival Cell. Microbiol. (IF 3.4) Pub Date : 2022-03-12 Annina Bindschedler, Jacqueline Schmuckli-Maurer, Rahel Wacker, Nicolas Kramer, Ruth Rehmann, Reto Caldelari, Volker T. Heussler
The protozoan parasite Plasmodium, causative agent of malaria, initially invades and develops in hepatocytes where it resides in a parasitophorous vacuole (PV). A single invaded parasite develops into thousands of daughter parasites. Survival of the host cell is crucial for successful completion of liver stage development. Nuclear factor erythroid-derived 2-related factor 2 (NRF2) is a transcription
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Cover Image: Entry of the Varicellovirus Canid herpesvirus 1 into Madin–Darby canine kidney epithelial cells is pH-independent and occurs via a macropinocytosis-like mechanism but without increase in fluid uptake (Cellular Microbiology 12/2021) Cell. Microbiol. (IF 3.4) Pub Date : 2021-12-09 Mohamed Eisa, Hamza Loucif, Julien van Grevenynghe, Angela Pearson
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Vam6/Vps39/TRAP1-domain proteins influence vacuolar morphology, iron acquisition and virulence in Cryptococcus neoformans Cell. Microbiol. (IF 3.4) Pub Date : 2021-11-20 Guanggan Hu, Erik Bakkeren, Mélissa Caza, Linda Horianopoulos, Eddy Sánchez-León, Melanie Sorensen, Wonhee Jung, James W. Kronstad
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Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane Cell. Microbiol. (IF 3.4) Pub Date : 2021-11-03 Lili Zhao, Fuwang Chen, Oliver Quitt, Marvin Festag, Marc Ringelhan, Karin Wisskirchen, Julia Festag, Luidmila Yakovleva, Camille Sureau, Felix Bohne, Michaela Aichler, Volker Bruss, Maxim Shevtsov, Maarten van de Klundert, Frank Momburg, Britta S. Möhl, Ulrike Protzer
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Chlamydia and HPV induce centrosome amplification in the host cell through additive mechanisms Cell. Microbiol. (IF 3.4) Pub Date : 2021-10-30 Kevin Wang, Karissa J. Muñoz, Ming Tan, Christine Sütterlin
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Entry of the Varicellovirus Canid herpesvirus 1 into Madin–Darby canine kidney epithelial cells is pH-independent and occurs via a macropinocytosis-like mechanism but without increase in fluid uptake Cell. Microbiol. (IF 3.4) Pub Date : 2021-10-25 Mohamed Eisa, Hamza Loucif, Julien van Grevenynghe, Angela Pearson
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Cover Image: The fungivorous amoeba Protostelium aurantium targets redox homeostasis and cell wall integrity during intracellular killing of Candida parapsilosis (Cellular Microbiology 11/2021) Cell. Microbiol. (IF 3.4) Pub Date : 2021-10-14 Silvia Radosa, Jakob L. Sprague, Siu-Hin Lau, Renáta Tóth, Jörg Linde, Thomas Krüger, Marcel Sprenger, Lydia Kasper, Martin Westermann, Olaf Kniemeyer, Bernhard Hube, Axel A. Brakhage, Attila Gácser, Falk Hillmann
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The fungivorous amoeba Protostelium aurantium targets redox homeostasis and cell wall integrity during intracellular killing of Candida parapsilosis Cell. Microbiol. (IF 3.4) Pub Date : 2021-08-30 Silvia Radosa, Jakob L. Sprague, Siu-Hin Lau, Renáta Tóth, Jörg Linde, Thomas Krüger, Marcel Sprenger, Lydia Kasper, Martin Westermann, Olaf Kniemeyer, Bernhard Hube, Axel A. Brakhage, Attila Gácser, Falk Hillmann
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Host manipulation by bacterial type III and type IV secretion system effector proteases Cell. Microbiol. (IF 3.4) Pub Date : 2021-08-14 Flávia Viana, Shruthi Sachidanandan Peringathara, Arshad Rizvi, Gunnar N. Schroeder
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Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of coxsackievirus and adenovirus receptor Cell. Microbiol. (IF 3.4) Pub Date : 2021-08-27 Hiroki Takeuchi, Shunsuke Yamaga, Naoko Sasaki, Masae Kuboniwa, Michiya Matsusaki, Atsuo Amano
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Rickettsia conorii survival in THP-1 macrophages involves host lipid droplet alterations and active rickettsial protein production Cell. Microbiol. (IF 3.4) Pub Date : 2021-08-31 Paige E. Allen, Robert C. Noland, Juan J. Martinez
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Dengue virus replication enhances labile zinc pools by modulation of ZIP8 Cell. Microbiol. (IF 3.4) Pub Date : 2021-10-07 Aleksha Panwar, Jigme Wangchuk, Meenakshi Kar, Rakesh Lodha, Guruprasad R. Medigeshi
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Cover Image: Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans (Cellular Microbiology 10/2021) Cell. Microbiol. (IF 3.4) Pub Date : 2021-09-23 Selene Mogavero, Frank M. Sauer, Sascha Brunke, Stefanie Allert, Daniela Schulz, Stephanie Wisgott, Nadja Jablonowski, Osama Elshafee, Thomas Krüger, Olaf Kniemeyer, Axel A. Brakhage, Julian R. Naglik, Edward Dolk, Bernhard Hube
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Egress of archaeal viruses Cell. Microbiol. (IF 3.4) Pub Date : 2021-09-13 Diana P. Baquero, Junfeng Liu, David Prangishvili
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Molecular Microbiology: A new vision and expanded scope Cell. Microbiol. (IF 3.4) Pub Date : 2021-08-17
Molecular Microbiology is announcing a new vision for the journal and is expanding both its scope and editorial board to cover innovative and emerging areas across all domains of microbiology. A new vision: Molecular Microbiology will encompass all areas of microbiology, from basic to translational research. The journal aims at attracting research content of the highest quality and novelty. It will
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Blockade of endoplasmic reticulum stress-induced cell death by Ureaplasma parvum vacuolating factor Cell. Microbiol. (IF 3.4) Pub Date : 2021-09-07 Fumiko Nishiumi, Yasuhiro Kawai, Yukiko Nakura, Michinobu Yoshimura, Heng Ning Wu, Mitsuhide Hamaguchi, Shigeyuki Kakizawa, Yo Suzuki, John I. Glass, Itaru Yanagihara
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BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae Cell. Microbiol. (IF 3.4) Pub Date : 2021-09-05 Zhiwei Huang, Hongsheng Dai, Xiaoyu Zhang, Qiao Wang, Jing Sun, Yunxia Deng, Ping Shi
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Zinc finger proteins of Plasmodium falciparum Cell. Microbiol. (IF 3.4) Pub Date : 2021-08-21 Che Julius Ngwa, Afia Farrukh, Gabriele Pradel
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Cover Image: Disassembly of the apical junctional complex during the transmigration of Leptospira interrogans across polarized renal proximal tubule epithelial cells (Cellular Microbiology 09/2021) Cell. Microbiol. (IF 3.4) Pub Date : 2021-08-17 Isabel Sebastián, Nobuhiko Okura, Bruno M. Humbel, Jun Xu, Idam Hermawan, Chiaki Matsuura, Malgorzata Hall, Chitoshi Takayama, Tetsu Yamashiro, Shuichi Nakamura, Claudia Toma