Diversification of the avian primary immunoglobulin (Ig) repertoire is achieved in developing B cells by somatic hypermutation (SHM) and gene conversion (GCV). GCV is a type of homologous recombination that unidirectionally transfers segments of Ig pseudogenes to Ig variable domains. It is regulated by epigenetic mechanisms like histone modifications, but the role of DNA methylation remains unclear

Many mutations in the fused in sarcoma (FUS) gene has been identified as genetic causative factors of amyotrophic lateral sclerosis (ALS). Since a certain number of mutants form aberrant cytoplasmic granules under specific conditions, granule forming ability of FUS is believed to be linked to the pathogenesis of ALS. However, molecular mechanisms underlying this property remains unclear. An ALS‐linked

Dual‐specificity phosphatase 6 (DUSP6) is a key negative feedback regulator of the member of the RAS‐ERK MAPK signaling pathway that is associated with cellular proliferation and differentiation. Deterioration of DUSP6 expression could therefore result in deregulated growth activity. We have previously discovered ACA‐28, a novel anti‐cancer compound with a unique property to stimulate ERK phosphorylation

Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S., & Nakayama, K. (2014) Identification and characterization of a neuron‐specific isoform of protrudin. Genes to Cells. 19, 97–111. In Experimental procedures, the first sentence under the sub‐heading “Construction of expression plasmids” should read as follows: Construction of expression plasmids Mouse cDNAs encoding protrudin‐S or protrudin‐L (Gen‐Bank

Han, Y., Nakayama, J., Hayashi, Y., Jeong, S., Futakuchi, M., Ito, E., … Semba, K. (2020) Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intracaudal arterial injection. Genes to Cells, 25, 111‐123. https://doi.org/10.1111/gtc.12743 The authors would like to draw the reader’s attention to the change in the email address of the corresponding author. The new