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GDF11: An emerging therapeutic target for liver diseases and fibrosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Pardis Habibi, Kimia Falamarzi, Niloofar Dehdari Ebrahimi, Mohammad Zarei, Mahdi Malekpour, Negar Azarpira
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP11), has been identified as a key player in various biological processes, including embryonic development, aging, metabolic disorders and cancers. GDF11 has also emerged as a critical component in liver development, injury and fibrosis. However, the effects of GDF11 on liver physiology and pathology have been
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Targeted inhibition of colorectal cancer proliferation: The dual-modulatory role of 2,4-DTBP on anti-apoptotic Bcl-2 and Survivin proteins J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Partha Saha, Mangala Hegde, Kanak Chakraborty, Achinta Singha, Nobendu Mukerjee, Deepshikha Ghosh, Ajaikumar B. Kunnumakkara, Mohd Shahnawaz Khan, Md Irshad Ahmad, Arabinda Ghosh, Ajoy Kumer, Samir Kumar Sil
The anti-apoptotic proteins, Bcl-2 and Survivin, are consistently overexpressed in numerous human malignancies, notably in colorectal cancer. 2,4-Di-tert-butylphenol (2,4-DTBP) is a naturally occurring phenolic compound known for its diverse biological activities, including anti-cancer properties. The mechanism behind 2,4-DTBP-induced inhibition of cell proliferation and apoptosis in human colorectal
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The cell death-related genes machine learning model for precise therapy and clinical drug selection in hepatocellular carcinoma J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Mingyang Du, Yonggang Qu, Lingshan Qin, Jiahe Zheng, Wei Sun
Hepatocellular carcinoma (HCC) is the prevailing subtype of hepatocellular malignancy. While previous investigations have evidenced a robust link with programmed cell death (PCD) and tumorigenesis, a comprehensive inquiry targeting the relationship between multiple PCDs and HCC remains scant. Our aim was to develop a predictive model for different PCD patterns in order to investigate their impact on
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Microglia orchestrate synaptic and neuronal stripping: Implication in neuropsychiatric lupus J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Yishan Zhou, Liang Chen, Xiulan Zheng, Qijun Fang, Yunzhi Qian, Tianshu Xu, Jun Liang, Huajun Zhang, Xiaojuan Han, Lingyun Sun
Systemic lupus erythematosus (SLE), a multifactorial autoimmune disease, can affect the brain and cause neuropsychiatric dysfunction, also named neuropsychiatric lupus (NPSLE). Microglial activation is observed in NPSLE patients. However, the mechanisms regulating microglia-mediated neurotoxicity in NPSLE remain elusive. Here, we showed that M1-like proinflammatory cytokine levels were increased in
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Research progress on the roles of dopamine and dopamine receptors in digestive system diseases J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Xianmin Lu, Qi Liu, Ya Deng, Jiangbo Wu, Xingyi Mu, Xiaoxu Yang, Ting Zhang, Chen Luo, Zhuo Li, Siqi Tang, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie
Dopamine (DA) is a neurotransmitter synthesized in the human body that acts on multiple organs throughout the body, reaching them through the blood circulation. Neurotransmitters are special molecules that act as messengers by binding to receptors at chemical synapses between neurons. As ligands, they mainly bind to corresponding receptors on central or peripheral tissue cells. Signalling through chemical
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CPA4 as a biomarker promotes the proliferation, migration and metastasis of clear cell renal cell carcinoma cells J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Kongjia Wang, Yixin Ding, Yunbo Liu, Mingyu Ma, Ji Wang, Zengshun Kou, Shuo Liu, Bo Jiang, Sichuan Hou
Clear cell renal cell carcinoma (ccRCC) is a commonly occurring and highly aggressive urological malignancy characterized by a significant mortality rate. Current therapeutic options for advanced ccRCC are limited, necessitating the discovery of novel biomarkers and therapeutic targets. Carboxypeptidase A4 (CPA4) is a zinc-containing metallocarboxypeptidase with implications in various cancer types
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Bilirubin ameliorates osteoarthritis via activating Nrf2/HO-1 pathway and suppressing NF-κB signalling J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Xinyu Zhao, Baiqun Duan, Jianing Wu, Lihui Huang, Sheng Dai, Jie Ding, Meng Sun, Xinlu Lin, Yiling Jiang, Tuyue Sun, Ruijie Lu, Huirong Huang, Guangyong Lin, Ruijie Chen, Qing Yao, Longfa Kou
Osteoarthritis (OA) is a chronic degenerative joint disease that affects worldwide. Oxidative stress plays a critical role in the chronic inflammation and OA progression. Scavenging overproduced reactive oxygen species (ROS) could be rational strategy for OA treatment. Bilirubin (BR) is a potent endogenous antioxidant that can scavenge various ROS and also exhibit anti-inflammatory effects. However
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Post-translational modifications in diabetic cardiomyopathy J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Zhi Li, Jie Chen, Hailong Huang, Qianru Zhan, Fengzhi Wang, Zihan Chen, Xinwei Lu, Guozhe Sun
The increasing attention towards diabetic cardiomyopathy as a distinctive complication of diabetes mellitus has highlighted the need for standardized diagnostic criteria and targeted treatment approaches in clinical practice. Ongoing research is gradually unravelling the pathogenesis of diabetic cardiomyopathy, with a particular emphasis on investigating various post-translational modifications. These
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Correction to Aureusidin derivative CNQX inhibits chronic colitis inflammation and mucosal barrier damage by targeting myeloid differentiation 2 protein J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17
In Yi Yang et al1, in the published version of the article, Figure 5A encountered an error during typesetting. The correct figure is shown below. The authors confirm all results, and conclusions of this article remain unchanged. FIGURE 5 Open in figure viewerPowerPoint The effect of CNQX on the expression of key protein of the TLR4 signal and tight junction protein (A) The expression of MD2 and tight
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Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Cengiz Tuncer, Ceyhan Hacioglu
Glioblastoma multiforme (GBM) is a highly aggressive and lethal form of primary brain tumour. Borax has been demonstrated to exhibit anti-cancer activity through cell death pathways. However, the specific impact of borax on ferroptosis in GBM is not well-established, and the underlying regulatory mechanisms remain unclear. Initially, the effective concentration of borax on cell viability and proliferation
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GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Wang Mengjia, Ji Jun, Zhang Xin, Zhang Jiahao, Guo Jie
Fracture of the alveolar bone resorption is a common complication in orthodontic treatment, which mainly caused by extreme mechanical loading. However, the ferroptosis with orthodontic tooth movement(OTM) relationship has not been thoroughly described. We here analysed whether ferroptosis is involved in OTM-associated alveolar bone loss. Mouse osteoblasts (MC-3T3) and knockdown glutathione peroxidase
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O-GlcNAc regulates anti-fibrotic genes in lung fibroblasts through EZH2 J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Qiuming P. Wu, Shia Vang, Jennifer Q. Zhou, Stefanie Krick, Jarrod W. Barnes, Yan Y. Sanders
Epigenetic modifications are involved in fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), and contribute to the silencing of anti-fibrotic genes. H3K27me3, a key repressive histone mark, is catalysed by the methyltransferase enhancer of Zeste homologue 2 (EZH2), which is regulated by the post-translational modification, O-linked N-Acetylglucosamine (O-GlcNAc). In this study, we explored
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The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Jie Zhao, Yaping Feng, Xin Liu, Huimin Li, Huilin Guo, Jin Ke, Xing Long
M1 macrophage polarization and synovitis play an important role in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA). Reduced molecular weight of hyaluronic acid (HA) in synovial fluid of patients with TMJOA. In addition, high molecular weight hyaluronic acid (HMW-HA) is often used clinically to treat TMJ inflammation. As a pattern recognition receptor of the cytoplasm, ALPK1 was found
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Avocado-derived extracellular vesicles loaded with ginkgetin and berberine prevent inflammation and macrophage foam cell formation J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Shweta Sharma, Manisha Mahanty, Suneha G. Rahaman, Pritha Mukherjee, Bidisha Dutta, Mohammad Imran Khan, Karunakaran Reddy Sankaran, Xiaoming He, Lakshmyya Kesavalu, Wei Li, Shaik O. Rahaman
Atherosclerosis, a chronic inflammatory disease of aorta, remains the major cause of morbidity and mortality among cardiovascular disease patients. Macrophage foam cell formation and inflammation are critically involved in early stages of atherosclerosis, hence chemopreventive targeting of foam cell formation by nutraceuticals may be a promising approach to curbing the progression of atherosclerosis
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Exploring the current landscape of single-cell RNA sequencing applications in gastric cancer research J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-17 Wireko Andrew Awuah, Sakshi Roy, Joecelyn Kirani Tan, Favour Tope Adebusoye, Zekai Qiang, Tomas Ferreira, Arjun Ahluwalia, Vallabh Shet, Amanda Leong Weng Yee, Toufik Abdul-Rahman, Marios Papadakis
Gastric cancer (GC) represents a major global health burden and is responsible for a significant number of cancer-related fatalities. Its complex nature, characterized by heterogeneity and aggressive behaviour, poses considerable challenges for effective diagnosis and treatment. Single-cell RNA sequencing (scRNA-seq) has emerged as an important technique, offering unprecedented precision and depth
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SGLT2i improves kidney senescence by down‐regulating the expression of LTBP2 in SAMP8 mice J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-08 Lu Zeng, Jie Li, Fanfan Gao, Yangyang Song, Limin Wei, Ning Qu, Shengnan Chen, Xue Zhao, Zitong Lei, Wenya Cao, Lei Chen, Hongli Jiang
Senescent kidney can lead to the maladaptive repairment and predispose age‐related kidney diseases. Here, we explore the renal anti‐senescence effect of a known kind of drug, sodium‐dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence‐accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine
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Sporoderm‐broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1‐mediated autophagy and tumour immunity J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-07 Rui Shen, Yang Ge, Yunpeng Qin, Hang Gao, Hongyan Yu, Huazhang Wu, Hang Song
Hepatoblastoma (HB), a primary liver tumour, is notorious for its high metastatic potential and poor prognosis. Ganoderma lucidum, an edible mushroom species utilized in traditional Chinese medicine for addressing various tumour types, presents an intriguing avenue for HB treatment. However, the effectiveness of G. lucidum in managing HB and its underlying molecular mechanism necessitates further exploration
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Identification of key biomarkers for predicting CAD progression in inflammatory bowel disease via machine‐learning and bioinformatics strategies J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-07 Xiaoqi Tang, Yufei Zhou, Zhuolin Chen, Chunjiang Liu, Zhifeng Wu, Yue Zhou, Fan Zhang, Xuanyuan Lu, Liming Tang
The study aimed to identify the biomarkers for predicting coronary atherosclerotic lesions progression in patients with inflammatory bowel disease (IBD). Related transcriptome datasets were seized from Gene Expression Omnibus database. IBD‐related modules were identified via Weighted Gene Co‐expression Network Analysis. The ‘Limma’ was applied to screen differentially expressed genes between stable
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Supplementing probiotics during intermittent fasting proves more effective in restoring ileum and colon tissues in aged rats J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-06 Hikmet Taner Teker, Taha Ceylani, Seda Keskin, Gizem Samgane, Hüseyin Allahverdi, Eda Acikgoz, Rafig Gurbanov
This study aimed to explore the impact of SCD Probiotics supplementation on biomolecule profiles and histopathology of ileum and colon tissues during a 30‐day intermittent fasting (IF) program. Male Sprague–Dawley rats, aged 24 months, underwent 18‐h daily fasting and received 3 mL (1 × 108 CFU) of SCD Probiotics. The differences in biomolecule profiles were determined using FTIR Spectroscopy and two
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circ_HMGCS1 modulates hepatocellular carcinoma chemoresistance via miR‐338‐5p/IL‐7 pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-06 Siyu Zhang, Jun Ma, Tingdong Yu, Zhengrui Song, Wan Yee Lau, Yong Zha
Hepatocellular cancer is one of the most serious types of cancer in the world, with high incidence and mortality rates. Most HCC patients with long‐term chemotherapy develop chemoresistance, leading to a poor prognosis. However, the underlying mechanism of circRNAs in HCC chemoresistance remains unclear. Our research found that circ_0072391(circ_HMGCS1) expression was significantly upregulated in cisplatin‐resistant
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Prebiotics counteract the morphological and functional changes secondary to chronic cisplatin exposition in the proximal colon of mice J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-06 Cristina Biagioni, Chiara Traini, Maria Simonetta Faussone‐Pellegrini, Eglantina Idrizaj, Maria Caterina Baccari, Maria Giuliana Vannucchi
Cisplatin is an antimitotic drug able to cause acute and chronic gastrointestinal side effects. Acute side effects are attributable to mucositis while chronic ones are due to neuropathy. Cisplatin has also antibiotic properties inducing dysbiosis which enhances the inflammatory response, worsening local damage. Thus, a treatment aimed at protecting the microbiota could prevent or reduce the toxicity
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Overexpression of malic enzyme is involved in breast cancer growth and is correlated with poor prognosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-06 Wan‐Chung Hu, Yi‐Fang Yang, Ching‐Feng Cheng, Ya‐Ting Tu, Hong‐Tai Chang, Kuo‐Wang Tsai
Malic enzyme (ME) genes are key functional metabolic enzymes playing a crucial role in carcinogenesis. However, the detailed effects of ME gene expression on breast cancer progression remain unclear. Here, our results revealed ME1 expression was significantly upregulated in breast cancer, especially in patients with oestrogen receptor/progesterone receptor‐negative and human epidermal growth factor
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Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-06 Li Tong, Xiaofei Zheng, Tianqi Wang, Wang Gu, Tingting Shen, Wenkang Yuan, Siyu Wang, Songlin Xing, Xiaoying Liu, Chong Zhang, Chao Zhang
Ubiquitin A‐52 residue ribosomal protein fusion product 1 (UBA52) has a role in the occurrence and development of tumours. However, the mechanism by which UBA52 regulates hepatocellular carcinoma (HCC) tumorigenesis and progression remains poorly understood. By using the Cell Counting Kit (CCK‐8), colony formation, wound healing and Transwell assays, we assessed the effects of UBA52 knockdown and overexpression
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Single‐cell transcriptomic analysis in clear cell renal cell carcinoma: Deciphering the role of APP within the tumour microenvironment J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-06 Bo Guan, Ming Li, Di Cui, Chen Shen, Zongyao Hao, Xiaowei Li
Clear cell renal cell carcinoma (ccRCC) represents a significant challenge in oncology, primarily due to its resistance to conventional therapies. Understanding the tumour microenvironment (TME) is crucial for developing new treatment strategies. This study focuses on the role of amyloid precursor protein (APP) in tumour‐associated macrophages (TAMs) within the ccRCC TME, exploring its potential as
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The SGLT family—sodium‐glucose transporters with roles beyond glucose and the kidney J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-06 David Mathew, Sean Davidson, Derek Yellon
The inhibition of urinary sodium-glucose reuptake via the SGLT2 transporter in the proximal tubule of the nephron was initially intended as a treatment for diabetes. However, the unexpected efficacy of SGLT2-inhibitors in improving both cardiovascular and renal outcomes has positioned this class of pharmacological agents centre-stage in the burgeoning era of preventative medicine.1 There are six named
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Retraction: The long non‐coding RNA‐ROR promotes osteosarcoma progression by targeting miR‐206 J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-05
Dan Fei, Guoqing Sui, Yang Lu, Long Tan, Zhao Dongxu, Kewei Zhang. The long non‐coding RNA‐ROR promotes osteosarcoma progression by targeting miR‐206. J Cell Mol Med. 2019; 23: 1865–1872. https://doi.org/10.1111/jcmm.14087.The above article, published online on 19 December 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief
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RPL35A drives ovarian cancer progression by promoting the binding of YY1 to CTCF promoter J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-04 Huijuan Wu, Liangbin Xia, Lu Sun, Dan Li, Xiangyu Liu, Hualin Song, Jindong Sheng, Ke Wang, Qinmei Feng
Ovarian cancer is one of the most common gynaecological malignancies with poor prognosis and lack of effective treatment. The improvement of the situation of ovarian cancer urgently requires the exploration of its molecular mechanism to develop more effective molecular targeted drugs. In this study, the role of human ribosomal protein l35a (RPL35A) in ovarian cancer was explored in vitro and in vivo
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Upregulation of POC1A in lung adenocarcinoma promotes tumour progression and predicts poor prognosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-02 Zi‐Hao Li, Jia‐Yi Li, Zuo‐Tao Wu, Yong‐Jie Zhu, Ting Zhuo, Ju‐Sen Nong, Jing Qian, Hua‐Jian Peng, Lei Dai, Yong‐Yong Wang, Ming‐Wu Chen, Xiao‐Chun Zeng
Lung adenocarcinoma (LUAD) is characterized by a high incidence rate and mortality. Recently, POC1 centriolar protein A (POC1A) has emerged as a potential biomarker for various cancers, contributing to cancer onset and development. However, the association between POC1A and LUAD remains unexplored. We extracted The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) data sets to analyse
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Identification of key regulatory molecules in the early development stage of Alzheimer's disease J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-02 Bin Huang, Guan‐yong Ou, Ni Zhang
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, the incidence of which increases with age, and the pathological changes in the brain are irreversible. Recent studies have highlighted the essential role of long noncoding RNAs (lncRNAs) in AD by acting as competing endogenous RNAs (ceRNAs). Our aim was to construct lncRNA‐associated ceRNA regulatory networks composed of
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STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-02 Jie Zhu, Wenjia Tang, Peiqi Fang, Chong Wang, Meixiu Gu, Wenjing Yang, Baishen Pan, Beili Wang, Wei Guo
HCC is a globally high‐incidence malignant tumour, and its pathogenesis is still unclear. Recently, STRN3 has been found to be elevated in various tumours, but its expression and biological functions in HCC have not been studied. In the study, clinical correlation analysis was performed on 371 liver cancer patients from TCGA database and liver cancer tissues and normal tissues from the GEO database
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Construction of endothelial cell signatures for predicting the diagnosis, prognosis and immunotherapy response of bladder cancer via machine learning J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-02 Yang Fu, Shanshan Sun, Du Shi, Jianbin Bi
We subtyped bladder cancer (BC) patients based on the expression patterns of endothelial cell (EC) ‐related genes and constructed a diagnostic signature and an endothelial cell prognostic index (ECPI), which are useful for diagnosing BC patients, predicting the prognosis of BC and evaluating drug sensitivity. Differentially expressed genes in ECs were obtained from the Tumour Immune Single‐Cell Hub
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METTL3 as a novel diagnosis and treatment biomarker and its association with glycolysis, cuproptosis and ceRNA in oesophageal carcinoma J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-02 Xu‐Sheng Liu, Yu Zhang, Zi‐Yue Liu, Yan Gao, Ling‐Ling Yuan, Dao‐Bing Zeng, Fan Tan, Hua‐Bing Wan, Zhi‐Jun Pei
METTL3 has been shown to be involved in regulating a variety of biological processes. However, the relationship between METTL3 expression and glycolysis, cuproptosis‐related genes and the ceRNA network in oesophageal carcinoma (ESCA) remains unclear. ESCA expression profiles from databases were obtained, and target genes were identified using differential analysis and visualization. Immunohistochemistry
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Identification of crosstalk genes relating to ECM‐receptor interaction genes in MASH and DN using bioinformatics and machine learning J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-02 Chao Chen, Yuxi He, Ying Ni, Zhanming Tang, Wensheng Zhang
This study aimed to identify genes shared by metabolic dysfunction‐associated fatty liver disease (MASH) and diabetic nephropathy (DN) and the effect of extracellular matrix (ECM) receptor interaction genes on them. Datasets with MASH and DN were downloaded from the Gene Expression Omnibus (GEO) database. Pearson's coefficients assessed the correlation between ECM‐receptor interaction genes and cross
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SIRT2‐mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-01 Xueying Zhang, Yue Xu, Shenglei Li, Yue Qin, Guangzhao Zhu, Qing Zhang, Yanting Zhang, Fangxia Guan, Tianli Fan, Hongtao Liu
ATP citrate lyase (ACLY), as a key enzyme in lipid metabolism, plays an important role in energy metabolism and lipid biosynthesis of a variety of tumours. Many studies have shown that ACLY is highly expressed in various tumours, and its pharmacological or gene inhibition significantly inhibits tumour growth and progression. However, the roles of ACLY in oesophageal squamous cell carcinoma (ESCC) remain
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CDDO regulates central and peripheral sensitization to attenuate post‐herpetic neuralgia by targeting TRPV1/PKC‐δ/p‐Akt signals J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-01 Chun‐Ching Lu, Chia‐Yang Lin, Ying‐Yi Lu, Hung‐Pei Tsai, Chih‐Lung Lin, Chieh‐Hsin Wu
Postherpetic neuralgia (PHN) is a notorious neuropathic pain featuring persistent profound mechanical hyperalgesia with significant negative impact on patients' life quality. CDDO can regulate inflammatory response and programmed cell death. Its derivative also protects neurons from damages by modulating microglia activities. As a consequence of central and peripheral sensitization, applying neural
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Rhizoma Paridis saponins attenuate Gram‐negative bacteria‐induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-01 Yang Yang, Chaofan Wang, Juan Wang, Lingli Yang, Zheng Lv, Quan An, Yiming Wang, Xue Shao, Fei Wang, Tong Huo, Jiali Liu, Haoshu Luo, Qianghua Quan
Acne vulgaris represents a chronic inflammatory condition, the pathogenesis of which is closely associated with the altered skin microbiome. Recent studies have implicated a profound role of Gram‐negative bacteria in acne development, but there is a lack of antiacne agents targeting these bacteria. Polyphyllins are major components of Rhizoma Paridis with great anti‐inflammatory potential. In this
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A systematic review on deep learning‐based automated cancer diagnosis models J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-01 Ritu Tandon, Shweta Agrawal, Narendra Pal Singh Rathore, Abhinava K. Mishra, Sanjiv Kumar Jain
Deep learning is gaining importance due to its wide range of applications. Many researchers have utilized deep learning (DL) models for the automated diagnosis of cancer patients. This paper provides a systematic review of DL models for automated diagnosis of cancer patients. Initially, various DL models for cancer diagnosis are presented. Five major categories of cancers such as breast, lung, liver
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Retraction: miR‐365 secreted from M2 Macrophage‐derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-24
Xin Li, Hao Xu, Jianfeng Yi, Chunlu Dong, Hui Zhang, Zhengfeng Wang, Long Miao, Wence Zhou. miR‐365 secreted from M2 Macrophage‐derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis. J Cell Mol Med. 2021; 25: 4671–4683. https://doi.org/10.1111/jcmm.16405.The above article, published online on 03 April 2021 in Wiley Online Library (wileyonlinelibrary
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IL‐8 from CD248‐expressing cancer‐associated fibroblasts generates cisplatin resistance in non‐small cell lung cancer J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-24 Jieheng Wu, Qiaoling Zhang, Jiangwei Wu, Zeyang Yang, Xinlei Liu, Chunju Lou, Xuanyin Wang, Jiangying Peng, Jinyuan Zhang, Zhenling Shang, Jing Xiao, Nianxue Wang, Ruya Zhang, Jinyao Zhou, Yun Wang, Zuquan Hu, Rui Zhang, Jian Zhang, Zhu Zeng
Chemotherapy‐resistant non‐small cell lung cancer (NSCLC) presents a substantial barrier to effective care. It is still unclear how cancer‐associated fibroblasts (CAFs) contribute to NSCLC resistance to chemotherapy. Here, we found that CD248+CAFs released IL‐8 in NSCLC, which, in turn, enhanced the cisplatin (CDDP) IC50 in A549 and NCI‐H460 while decreasing the apoptotic percentage of A549 and NCI‐H460
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Calotropis procera extract inhibits prostate cancer through regulation of autophagy J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-23 Palak Singh, Bodhana Dhole, Jaganmoy Choudhury, Anannya Tuli, Deepak Pandey, Thirumurthy Velpandian, Surabhi Gupta, Pradeep Kumar Chaturvedi
Current treatment options available for prostate cancer (PCa) patients have many adverse side effects and hence, new alternative therapies need to be explored. Anticancer potential of various phytochemicals derived from Calotropis procera has been studied in many cancers but no study has investigated the effect of leaf extract of C. procera on PCa cells. Hence, we investigated the effect of C. procera
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Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the molecular feature of M2 macrophages of head and neck squamous cell carcinoma J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-23 Siyuan Wu, Xiaozhi Lv, Haigang Wei, Jialin Wu, Shiwei Liu, Xia Li, Jing Song, Chen Zou, Yilong Ai
The connection between head and neck squamous cell carcinoma (HNSC) and M2 tumour-associated macrophages is not yet fully understood. We gathered gene expression profiles and clinical data from HNSC patients in the TCGA database. Using Consensus Clustering, we categorized these patients into M2 macrophage-related clusters. We developed a M2 macrophage-related signature (MRS) through statistical analyses
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Plasminogen activator inhibitor-1 serum levels in frontotemporal lobar degeneration J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-22 Francesco Angelucci, Katerina Veverova, Alžbeta Katonová, Martin Vyhnalek, Jakub Hort
Plasminogen activator inhibitor-1 (PAI-1) impedes brain plasmin synthesis. Reduced plasmin activity facilitates cumulation of amyloid beta (Aβ) in Alzheimer's disease (AD). Since plasmin also regulates the synaptic activity, it is possible that altered PAI-1 is present in other neurodegenerative disorders. We investigated whether PAI-1 and its counter-regulatory tissue plasminogen activator (tPA) are
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Still water run deep: Therapeutic TP effect of ucMSC-Ex via regulating mTOR to enhance autophagy J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-15 Zhirong Zhao, Li Han, Mei Xin, Lichen Zhou, Kexin Jiang, Qian Huang, Ruiwu Dai
Our previous study confirmed that umbilical cord mesenchymal stem cells-exosomes (ucMSC-Ex) inhibit apoptosis of pancreatic acinar cells to exert protective effects. However, the relationship between apoptosis and autophagy in traumatic pancreatitis (TP) has rarely been reported. We dissected the transcriptomics after pancreatic trauma and ucMSC-Ex therapy by high-throughput sequencing. Additionally
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Atractylodes macrocephala III suppresses EMT in cervical cancer by regulating IGF2BP3 through ETV5 J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-15 Meixia Wang, Jingwen Meng, Hongyun Wang, Huijuan Hu, Ying Hong
Atractylodes macrocephala III (ATL III), with anti-inflammatory and antitumor effects, is the main compound of Atractylodes macrocephala. Whether ATL III has an effect on cervical cancer and the specific mechanism are still unclear. Here, we investigated the effects of ATL III on cervical cancer cells at different concentrations and found that ATL III downregulates insulin-like growth factor 2 mRNA-binding
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Transcriptomic analysis of Porphyromonas gingivalis-infected head and neck cancer cells: Identification of PLAU as a candidate prognostic biomarker J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-16 Masakazu Hamada, Hiroaki Inaba, Kyoko Nishiyama, Sho Yoshida, Yoshiaki Yura, Michiyo Matsumoto-Nakano, Narikazu Uzawa
Periodontal disease is a risk factor for head and neck squamous cell carcinoma (HNSCC), and Porphyromonas gingivalis, a major periodontal pathogen, has been identified as a specific and potentially independent microbial factor that increases the risk of cancer mortality. Gene expression in HNSCC due to P. gingivalis infection and how changes in gene expression affect the prognosis of HNSCC patients
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Corrigendum J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-19
Correction to Circular Rna Mylk Promotes Tumour Growth and Metastasis via Modulating Mir-513a-5p/Vegfc Signalling in Renal Cell Carcinoma Li J, Huang CC, Zou Y, Jing Y, Gui Y. Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/VEGFC signalling in renal cell carcinoma. J Cell Mol Med, 2020 Jun; 24(12):6609–6621. doi: 10.1111/jcmm.15308. After publication of the article
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The impact of genomic distance on enhancer‐promoter interactions at the CFTR locus J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-19 Jenny L. Kerschner, Frederick Meckler, Giuliana C. Coatti, Nirbhayaditya Vaghela, Alekh Paranjapye, Ann Harris
We identified and characterized multiple cell‐type selective enhancers of the CFTR gene promoter in previous work and demonstrated active looping of these elements to the promoter. Here we address the impact of genomic spacing on these enhancer:promoter interactions and on CFTR gene expression. Using CRISPR/Cas9, we generated clonal cell lines with deletions between the −35 kb airway enhancer and the
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Targeting type H vessels in bone-related diseases J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-14 Juan Xu, Shuang-jian He, Ting-ting Xia, Yu Shan, Liang Wang
Blood vessels are essential for bone development and metabolism. Type H vessels in bone, named after their high expression of CD31 and Endomucin (Emcn), have recently been reported to locate mainly in the metaphysis, exhibit different molecular properties and couple osteogenesis and angiogenesis. A strong correlation between type H vessels and bone metabolism is now well-recognized. The crosstalk between
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Exosome inhibition improves response to first-line therapy in small cell lung cancer J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-14 Nesrin Irep, Kubilay Inci, Pervin Elvan Tokgun, Onur Tokgun
Exosomes are recognized as important mediators of cell-to-cell communication, facilitating carcinogenesis. Although there have been significant advancements in exosome research in recent decades, no drugs that target the inhibition of sEV secretion have been approved for human use. For this study, we employed GW4869 and Nexinhib20 as inhibitors of exosome synthesis and trafficking combined. First,
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ITGBL1 promotes anoikis resistance and metastasis in human gastric cancer via the AKT/FBLN2 axis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-08 Kanger Shen, Wei Xia, Kun Wang, Juntao Li, Wei Xu, Haoran Liu, Kexi Yang, Jinghan Zhu, Jiayu Wang, Qinhua Xi, Tongguo Shi, Rui Li
The resistance to anoikis plays a critical role in the metastatic progression of various types of malignancies, including gastric cancer (GC). Nevertheless, the precise mechanism behind anoikis resistance is not fully understood. Here, our primary focus was to examine the function and underlying molecular mechanism of Integrin beta-like 1 (ITGBL1) in the modulation of anoikis resistance and metastasis
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Effect of fentanyl and remifentanil on neuron damage and oxidative stress during induction neurotoxicity J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-08 Ali Taghizadehghalehjoughi, Muhammet Emin Naldan, Yesim Yeni, Sidika Genc, Ahmet Hacimuftuoglu, Mesut Isik, Adem Necip, İsmail Bolat, Serkan Yildirim, Sukru Beydemir, Mahmut Baykan
Opioids can be used for medical and non-medical purposes. Chronic pain such as cancer, as well as the frequent use of such drugs in places such as operating rooms and intensive care units, and in non-medical areas like drug abuse the effects and side effects of these drugs need to be examined in more detail. For this purpose, the effects of fentanyl and remifentanil drugs on neuroinflammation, oxidative
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Identification of the shared genes in type 2 diabetes mellitus and osteoarthritis and the role of quercetin J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-08 Siyuan Song, Jiangyi Yu
This study investigated the underlying comorbidity mechanism between type 2 diabetes mellitus (T2DM) and osteoarthritis (OA), while also assessing the therapeutic potential of quercetin for early intervention and treatment of these two diseases. The shared genes were obtained through GEO2R, limma and weighted gene co-expression network analysis (WGCNA), and validated using clinical databases and the
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Methyltransferase-like 3 mediated RNA m6A modifications in the reproductive system: Potentials for diagnosis and therapy J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-08 Xiaojuan Su, Ruifeng Lu, Yi Qu, Dezhi Mu
Several studies have highlighted the functional indispensability of methyltransferase-like 3 (METTL3) in the reproductive system. However, a review that comprehensively interprets these studies and elucidates their relationships is lacking. Therefore, the present work aimed to review studies that have investigated the functions of METTL3 in the reproductive system (including spermatogenesis, follicle
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Livin is protective in UVB-induced skin photodamage by regulating keratinocyte activation and inflammatory responses J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-08 Kaijie Wang, Xiaolan You, Zhenri Qu, Delu Che, Xianwei Cao
UVB radiation can lead to skin photodamage, which might arise from keratinocyte (KC) activation. Nuclear factor kappa B (NF-κB) assumes an essential function in the context of UVB-triggered skin photodamage. Initiating the NF-κB cascade leads to the release of inflammatory factors from KCs. Livin can modulate both KC activation and function, yet it remains uncertain whether and how Livin regulates
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Systemic inflammation and its relationship with pruritus in early-stage mycosis fungoides J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-08 Berna Solak, Rabia Öztaş Kara
The underlying mechanisms mycosis fungoides (MF)-related pruritus remain unclear, and the link between pruritus and systemic inflammation in MF is unexplored. We aimed to investigate systemic inflammation in MF patients and its potential connection to pruritus. In this retrospective study, demographic characteristics, MF stage, clinical and laboratory findings, and neutrophil-lymphocyte ratio (NLR)
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Temperature-sensitive hydrogel releasing pectolinarin facilitate scarless wound healing J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-08 Xiaohang Chen, Haoyue Song, Kun Song, Yuan Zhang, Jia Wang, Jinjia Hong, Qingpeng Xie, Jing Zhao, Meixian Liu, Xing Wang
The dressing that promotes scarless healing is essential for both normal function and aesthetics after a wound. With a deeper understanding of the mechanisms involved in scar formation during the wound healing process, the ideal dressing becomes clearer and more promising. For instance, the yes-associated transcriptional regulator (YAP) has been extensively studied as a key gene involved in regulating
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Adenine base editor-based correction of the cardiac pathogenic Lmna c.1621C > T mutation in murine hearts J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-08 Luzi Yang, Zhanzhao Liu, Jinhuan Sun, Zhan Chen, Fei Gao, Yuxuan Guo
Base editors are emerging as powerful tools to correct single-nucleotide variants and treat genetic diseases. In particular, the adenine base editors (ABEs) exhibit robust and accurate adenine-to-guanidine editing capacity and have entered the clinical stage for cardiovascular therapy. Despite the tremendous progress using ABEs to treat heart diseases, a standard technical route toward successful ABE-based
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α-Solanine attenuates chondrocyte pyroptosis to improve osteoarthritis via suppressing NF-κB pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-02-12 Jinyi Zhou, Jinting Wu, Fangda Fu, Sai Yao, Wenbiao Zheng, Weibin Du, Huan Luo, Hongting Jin, Peijian Tong, Chengliang Wu, Hongfeng Ruan
α-Solanine has been shown to exhibit anti-inflammatory and anti-tumour properties; however, its efficacy in treating osteoarthritis (OA) remains ambiguous. The study aimed to evaluate the therapeutic effects of α-solanine on OA development in a mouse OA model. The OA mice were subjected to varying concentrations of α-solanine, and various assessments were implemented to assess OA progression. We found