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Evaluation of recombinant human SP-D in the rat premature lung model Ann. Anat. (IF 2.388) Pub Date : 2021-01-11 Raquel Arroyo; Shawn N. Grant; Kara R. Gouwens; Deja M. Miller; Paul S. Kingma
Background The lungs of premature and term babies are structurally different from the adult lungs. Preterm lungs are underdeveloped, non-compliant in terms of breathing, often need mechanical ventilation and these patients commonly develop syndromes as a consequence of their prematurity, such as bronchopulmonary dysplasia (BPD). Surfactant protein SP-D could be a therapy for BPD. However, there is
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c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway Ann. Anat. (IF 2.388) Pub Date : 2021-01-09 Yanxia Huang; Shuchao Wang; Fei Huang; Qi Zhang; Bo Qin; Lvshuang Liao; Mi Wang; Hao Wan; Weitao Yan; Dan Chen; Fengxia Liu; Bing Jiang; Dan Ji; Xiaobo Xia; Jufang Huang; Kun Xiong
Cellular FLICE-inhibitory protein (c-FLIP), an anti-apoptotic regulator, shows remarkable similarities to caspase-8, which plays a key role in the cleavage of gasdermin D (GSDMD). It has been reported that the oxygen-glucose deprivation/recovery (OGD/R) model and lipopolysaccharide (LPS)/adenosine triphosphate (ATP) treatment could induce inflammation and pyroptosis. However, the regulatory role of
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Immunohistochemical expression of non-collagenous extracellular matrix molecules involved in tertiary dentinogenesis following direct pulp capping: a systematic review Ann. Anat. (IF 2.388) Pub Date : 2021-01-02 C. Călin; M. Sajin; V.T. Moldovan; C. Coman; S.I. Stratul; A.C. Didilescu
Background Extracellular matrix molecules (ECMM) expression during tertiary dentinogenesis provides useful information for regenerative applications and efficacy of pulp capping materials. Aim To identify and review the expression and roles of non-collagenous ECMM after successful direct pulp capping (DPC), following mechanical pulp exposures, via immunohistochemistry (IHC). The study addressed the
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Mississippi’s whole body donors: Analysis of donor pool demographics and their rationale for donation Ann. Anat. (IF 2.388) Pub Date : 2021-01-02 Caroline M. Mueller; Sara M. Allison; Marianne L. Conway
Background Whole body donation (WBD) is fundamental to anatomical education and research because human dissection provides an educational tool for training healthcare professionals. Investigation into the demographics and rationale of whole body donors can provide insight on who donates their bodies to science. Literature reports a typical donor who is a 60 to 70-year-old, white, married, educated
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The expression patterns of IL-1β and IL-10 and their relation to CYP epoxygenases in normal human placenta Ann. Anat. (IF 2.388) Pub Date : 2021-01-10 Zdenek Tauber; Katarina Chroma; Romana Baranova; Katerina Cizkova
Introduction The success of pregnancy depends on the regulation of immunological processes in the placenta. Important mediators of an immune response include pro- and anti-inflammatory interleukins which may be regulated by CYP epoxygenases and their metabolites. The relation between interleukins and CYP epoxygenases expression in human placenta has not yet been studied vastly. Material and Methods
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The distribution of conjunctival goblet cells in mice Ann. Anat. (IF 2.388) Pub Date : 2021-01-02 Jessica Welss; Nichapa Punchago; Jessica Feldt; Friedrich Paulsen
Purpose To evaluate the density and distribution of conjunctival goblet cells in mice without clinical evidence of ocular surface diseases. Methods Immediately after euthanasia of C57BL/6 wild-type mice, the eyes including eyelids were removed and fixed in paraformaldehyde. Entire eyeballs and eyelids were cut in series along the sagittal axis from nasal to temporal on a microtome and then stained
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Mapping the amelogenin protein expression during porcine molar crown development Ann. Anat. (IF 2.388) Pub Date : 2021-01-02 Xiaohua Dai; Xiaoli Lian; Guanhua Wang; Jianwei Shang; Le Zhang; Qingzhi Zhang; Han Lei; Yan Yan; Yue Wang; Huiru Zou
Introduction Amelogenin (AMEL) plays critical roles during enamel and dentin matrix deposition and mineralization. Most studies focused on the expression patterns of AMEL through the bud, cap, and bell stages. The spatial-temporal expression of AMEL protein during different mineralization stages, especially from presence of crypts to crown completed stages, remains unknown. Thus, the distribution pattern
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Gene expression and phosphorylation of ERK and AKT are regulated depending on mechanical force and cell confluence in murine cementoblasts Ann. Anat. (IF 2.388) Pub Date : 2021-01-02 Irma Azraq; Rogerio B. Craveiro; Christian Niederau; Julia Brockhaus; Asisa Bastian; Isabel Knaup; Sabine Neuss; Michael Wolf
Cementoblasts, located on the tooth root surface covered with cementum, are considered to have tooth protecting abilities. They prevent tissue damage and secure teeth anchorage inside the periodontal ligament during mechanical stress. However, the involvement of cementoblasts in mechanical compression induced periodontal remodeling needs to be identified and better understood. Here, we investigated
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Teaching anatomy under COVID-19 conditions at German universities: recommendations of the teaching commission of the anatomical society Ann. Anat. (IF 2.388) Pub Date : 2021-01-02 Anja Böckers; Horst Claassen; Kirsten Haastert-Talini; Jürgen Westermann
Background In this viewpoint representatives of the Teaching Commission of the Anatomical Society summarize their teaching experiences gained during the COVID-19 pandemic in the summer term of 2020 and derive first recommendations concerning face-to-face and remote teaching of anatomy for the future. Methods Representatives of the Teaching Commission of the Anatomical Society met virtually, exchanged
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Dynamic changes in the infrapatellar knee structures with quadriceps muscle contraction. An in vivo study Ann. Anat. (IF 2.388) Pub Date : 2020-12-30 Esperanza Naredo; Juan J. Canoso; Janeth Yinh; Karen Salomon-Escoto; Robert A. Kalish; Virginia Pascual-Ramos; Lina Martínez-Estupiñán; Eugene Kissin
Objective To determine the effect of knee flexion and submaximal isometric quadriceps muscle (Q) contraction on the patellar tendon (PT), the infrapatellar fat pad (IPFP), and the deep infrapatellar bursa (IPB) from extension to full flexion. Methods In Study 1, the dominant knee of seven healthy subjects was studied in full extension and at 60 degrees flexion during relaxation and Q contraction. Each
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The whole body donation program at the university of Bologna: A report based on the experience of one of the oldest university in Western world Ann. Anat. (IF 2.388) Pub Date : 2020-12-17 Ester Orsini; Marilisa Quaranta; Stefano Ratti; Giulia Adalgisa Mariani; Sara Mongiorgi; Anna Maria Billi; Lucia Manzoli
Human body dissection is fundamental in medical education, as it allows future physicians to learn about the body’s morphology in three dimensions, to recognize anatomical variations and to develop and increase the essential qualities of respect, compassion and empathy for patients. It is equally important in clinical training as it allows surgeons to improve their manual dexterity and practical skills
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A ratio to approximate the proximodistal extent of the flexor retinaculum in relation to the hand length Ann. Anat. (IF 2.388) Pub Date : 2020-12-17 Alexandra Fochtmann-Frana; Bettina Pretterklieber; Karl Dorfmeister; Michael L. Pretterklieber
The flexor retinaculum of the hand is a fibrous structure forming the carpal tunnel in conjunction with the carpal bones. To prevent incomplete release of the carpal tunnel it is of benefit to know about the expected longitudinal expansion of the flexor retinaculum. The objective of the present study was to identify a possible correlation between the proximodistal expansion of the flexor retinaculum
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Popliteal artery: Anatomical study and review of the literature Ann. Anat. (IF 2.388) Pub Date : 2020-12-02 Paloma Aragonés; Marc Rodríguez-Niedenführ; Sara Quinones; Clara Simón de Blas; Marko Konschake; José Ramón Sanudo; María Teresa Vázquez
Background The frequency of appearance of anatomical variability in the terminal division of the popliteal artery (PA) is different according to the type of sample used, and ranges from 2% to 21%. The PA locates 1,01 cm behind to the lateral meniscus, which makes it vulnerable during surgical procedures. Iatrogenic injury of the PA or its terminal branches increases if anatomical variables are present
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Cross-sectional analysis of spatial distribution and total amount of harvestable calvarian split bone Ann. Anat. (IF 2.388) Pub Date : 2020-12-02 Florian Peters; Marisa Wingels; Stephan Christian Möhlhenrich; Stefan Raith; Marie Sophie Katz; Anna Bock; Frank Hölzle; Ali Modabber
Background Bone resorption of the jaw leads to challenging implant placement. Frequently, augmentation of the jaw is necessary. Is calvarian split bone an alternative to other extraoral donor sites and what volume of bone is harvestable? The aim was to evaluate the spatial distribution and the total amount of harvestable calvarian split bone. Material and Methods Computerized tomographies of 600 patients
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Novel method for determining bone dimensions relevant for longitudinal and transverse distraction osteogenesis and application in the human tibia and fibula Ann. Anat. (IF 2.388) Pub Date : 2020-12-02 A.T. Bachmeier; E. Euler; R. Bader; W. Böcker; P.H. Thaller
Background In distraction osteogenesis (DO) of long bones, new bone tissue is formed and distracted to lengthen limbs or reconstruct bone defects. However, certain anthropometric quantities relevant for biomechanical modelling of DO are unknown, such as areas where new bone tissue is formed. We developed a novel method to facilitate the determination of these distraction areas (DA), which we applied
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Developing the rabbit canalicular injury model: Biophysical changes of masterkaR stents and implications for future research Ann. Anat. (IF 2.388) Pub Date : 2020-12-02 Swati Singh; Nikolaos Trakos; Mohammad Javed Ali
Background To describe the preparation of a rabbit lacrimal canalicular injury model, assess the canalicular healing, and determine the suitability of this model to study the biophysical changes of mono-canalicular stents. Methods Twelve canaliculi of twelve eyes of six healthy New Zealand white rabbits were included in the study. A canalicular injury model was prepared under general anesthesia. The
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Lesions in the lungs of fatal corona virus disease Covid-19 Ann. Anat. (IF 2.388) Pub Date : 2020-12-03 Colya N. Englisch; Thomas Tschernig; Fidelis Flockerzi; Carola Meier; Rainer M. Bohle
The corona virus outbreak in Wuhan, China, at the end of 2019 has rapidly evolved into a pandemic which is still virulent in many countries. An infection with SARS-CoV-2 can lead to corona virus disease (Covid-19). This paper presents an overview of the knowledge gained so far with regard to histopathological lung lesions in fatal courses of Covid-19. The main findings were diffuse alveolar damage
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Oral and maxillofacial surgeons’ assessment of the role of Pernkopf’s atlas in surgical practice Ann. Anat. (IF 2.388) Pub Date : 2020-11-07 Andrew Yee; Jessica Li; Joshua Lilly; Sabine Hildebrandt; William E. Seidelman; Doug Brown; Piroska Kopar; J. Henk. Coert; Susan E. Mackinnon; Howard A. Israel
Background The use of the Pernkopf atlas of human anatomy in surgery presents ethical challenges due to the author’s association with the Nazi regime and the potential depiction of victims of this regime. The atlas was of particular utility to two surgical specialties: nerve surgeons and oral and maxillofacial surgeons. The representation of peripheral nerves and complex head and neck anatomy is probably
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Intramedular transfer of the flexor digitorum brevis tendon for the correction of clawtoe/hammertoe deformity: A cross-sectional study Ann. Anat. (IF 2.388) Pub Date : 2020-11-25 Julia Cosín-Matamoros; Ricardo Becerro-de-Bengoa-Vallejo; Marta Elena Losa-Iglesias; Israel Casado-Hernández; María Benito-de-Pedro; César Calvo-Lobo; Eduardo Pérez-Boal; David Rodríguez-Sanz; Daniel López-López
Background A literature review did not reveal any studies concerning the intramedullary transfer of the flexor digitorum brevis tendons (FDB) technique with a single longitudinal incision through the proximal phalanx of the toes. The main goal of this investigation was to demonstrate whether the FDB tendons of the toes are long enough to enable intramedullary transfer to the dorsal area of the proximal
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Can Dasatinib Ameliorate the Hepatic changes, Induced by Long Term Western Diet, in Mice? Ann. Anat. (IF 2.388) Pub Date : 2020-11-02 Hassan Reda Hassan Elsayed; Mohammad El-Nablaway; Basma H. Othman; Asim Mohammed Abdalla; Eman Mohammad El Nashar; Mostafa Mohammed Abd-Elmonem; Randa El-Gamal
Background Non-alcoholic fatty liver disease (NAFLD) is a worldwide disease that progresses into steatohepatitis (NASH) that has no current effective treatment. This study aimed, for the first time, to investigate the effect of Dasatinib; a tyrosine kinase inhibitor showing anti-PDGFR activity with a macrophage modulating efficacy, on NASH. Methods NASH was induced, in C57BL/6 mice by western diet
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Distinguished properties of cells isolated from the dentin-pulp interface Ann. Anat. (IF 2.388) Pub Date : 2020-11-16 Marialucia Gallorini; Stephanie Krifka; Matthias Widbiller; Agnes Schröder; Christoph Brochhausen; Amelia Cataldi; Karl-Anton Hiller; Wolfgang Buchalla; Helmut Schweikl
Background Dental odontoblasts produce dentin mineralized matrix, trigger immune responses and act as sensory cells. The understanding of the mechanisms of these functions has been particularly restricted due to the lack of odontoblasts being cultivable in vitro. Because of the lack of specific markers to identify cells of the odontoblastic lineage, properties of the cells isolated from the dentin-pulp
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Immunohistochemical evidence of striated muscle cells within midfacial superficial musculoaponeurotic system Ann. Anat. (IF 2.388) Pub Date : 2020-11-20 Tudor Sandulescu; Judith Weniger; Stathis Philippou; Thomas Mücke; Ella A. Naumova; Wolfgang H. Arnold
Introduction The superficial musculoaponeurotic system (SMAS) is a controversial functional fibro-adipose layer that connects the mimic muscles to the skin and is involved in a variety of facial mimic expressions. The presence of muscle fibers within SMAS fibrous septa is hypothetical. The present study analyzed SMAS fibrous septa composition for the existence of striated muscle cells. Methods Histological
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Simvastatin accelerates the healing process of burn wound in Wistar rats through Akt/mTOR signaling pathway Ann. Anat. (IF 2.388) Pub Date : 2020-12-02 Parisa Ramhormozi; Javad Mohajer Ansari; Sara Simorgh; Hamid Reza Asgari; Mohammad Najafi; Mahmood Barati; Azar Babakhani; Maliheh Nobakht
Statins, apart from cholesterol-lowering properties, have wound healing effects. Hereby, we aimed to assess the impact of Simvastatin (SMV), one of the most commonly used statins, on Akt/mTOR signaling pathway during burn wound healing process. After creating a second-degree burn on the dorsal area of adult male Wistar rats (n = 60), they were randomly divided into the control, SMV, vehicle of Simvastatin
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CXCL5, CXCL8, and CXCL10 regulation by bacteria and mechanical forces in periodontium Ann. Anat. (IF 2.388) Pub Date : 2020-11-20 Birgit Rath-Deschner; Svenja Memmert; Anna Damanaki; Rafael S. de Molon; Marjan Nokhbehsaim; Sigrun Eick; Christian Kirschneck; Joni A. Cirelli; James Deschner; Andreas Jäger; Andressa V.B. Nogueira
Objective The aim of the present study was to evaluate the expressions of CXCL5, CXCL8, and CXCL10 in periodontal cells and tissues in response to microbial signals and/or biomechanical forces. Methods Human gingival biopsies from inflamed and healthy sites were used to examine the chemokine expressions and protein levels by real-time PCR and immunohistochemistry. The chemokines were also investigated
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The arterial blood supply of the symphysis pubis – Spatial orientated and highly variable Ann. Anat. (IF 2.388) Pub Date : 2020-11-20 Philipp Pieroh; Zhong-Lian Li; Shinichi Kawata; Yuki Ogawa; Christoph Josten; Hanno Steinke; Faramarz Dehghani; Masahiro Itoh
Background Open surgical treatment of the pubic region and adductor related pathologies require an exact knowledge of the arterial blood supply of the symphysis pubis that seems furthermore important to explain the hematogenous occurrence of symphysitis. Pubic bone marrow oedema (PBME) is a frequent occurring magnetic resonance imaging finding in groin pain. However, even asymptomatic athletes present
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The anatomical reliability of the superficial circumflex iliac artery perforator (SCIP) flap Ann. Anat. (IF 2.388) Pub Date : 2020-10-28 Cédric Zubler; David Haberthür; Ruslan Hlushchuk; Valentin Djonov; Mihai A. Constantinescu; Radu Olariu
Introduction In order to achieve a satisfactory functional and aesthetic result a thin skin flap is often required in surgical reconstruction of various body regions. Perforator flaps based on either the superficial or deep branch of the superficial circumflex iliac artery (SCIA) have been used for this purpose mainly in the Asian population. Recently the superficial plane has been established as a
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Animal model considerations to evaluate prosthetic tricuspid valve implants Ann. Anat. (IF 2.388) Pub Date : 2020-11-01 Olivier Chevènement; Nicolas Borenstein; Robert Kieval; Laurence Fiette; Fabienne Aujard
Aims Determining tricuspid valve comparative anatomy and appropriate animal models for preclinical evaluation of prosthetic tricuspid valve implants. Methods and results We described and measured 81 heart specimens: 12 humans, 22 dogs, 21 sheep and 26 pigs. Tricuspid annulus circumference varied in humans from 109 to 149 mm, in pigs from 85 to 140 mm, and were ≤125 mm in dogs and sheep. Tricuspid leaflet
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Morphological variability of the extensor hallucis longus in human fetuses Ann. Anat. (IF 2.388) Pub Date : 2020-11-07 Piotr Karauda; R. Shane Tubbs; Michał Polguj; Łukasz Olewnik
Introduction The extensor hallucis longus originates from about the middle three fifths of the anterior surface of the fibula, medial to the origin of the extensor digitorum longus, and inserts into the distal phalanx of the great toe. The goal of this study was to examine the insertion of the extensor hallucis longus tendon and thus prepare its first classification in human fetuses. Material and Methods
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Senescence and adiponectin signaling — Studies in canine testis Ann. Anat. (IF 2.388) Pub Date : 2020-10-20 Grzegorz Ramisz; Wiktor Turek; Maria Chmurska-Gasowska; Agnieszka Rak; Agnieszka Pietsch-Fulbiszewska; Anna Galuszka; Malgorzata Kotula-Balak; Kazimierz Tarasiuk
Background The meaning of senescence for tissue physiological and pathological conditions is poorly known. Based on initial reports especially proteins and mechanisms that regulate this process are necessary to be determinate. Methods The main aim of the study was to investigate the presence of senescent cells in canine testicular tissue (mixed breed testes; n = 60) in relation to adiponectin signaling
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Accuracy evaluation of patient-specific 3D-printed aortic anatomy Ann. Anat. (IF 2.388) Pub Date : 2020-11-01 Mark Kaschwich; Marco Horn; Sarah Matthiensen; Erik Stahlberg; Christian-Alexander Behrendt; Florian Matysiak; Juljan Bouchagiar; Annika Dell; David Ellebrecht; Andreas Bayer; Markus Kleemann
Introduction 3D printing has a wide range of applications in medicine. In surgery, this technique can be used for preoperative planning of complex procedures, production of patient specific implants, as well as training. However, accuracy evaluations of 3D vascular models are rare. Objectives Aim of this study was to investigate the accuracy of patient-specific 3D-printed aortic anatomies. Methods
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Comparative anatomy and morphology of the knee in translational models for articular cartilage disorders. Part II: Small animals Ann. Anat. (IF 2.388) Pub Date : 2020-10-29 Tamás Oláh; Jana Christin Michaelis; Xiaoyu Cai; Magali Cucchiarini; Henning Madry
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The Czech contribution to the history of anatomy: A focus on Charles University Ann. Anat. (IF 2.388) Pub Date : 2020-11-07 David Kachlik; Adam Whitley
This article offers a concise overview of the history of the study of anatomy and dissection in the Czech lands, now known as the Czech Republic, from the founding of Charles University to the present day. The article traces this history in the context of the political changes that occurred over six hundred and seventy-two years, giving emphasis to the history of Prague’s anatomy departments, its leading
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The subscapularis tendon: A proposed classification system Ann. Anat. (IF 2.388) Pub Date : 2020-10-15 Nicol Zielinska; R. Shane Tubbs; Michał Podgórski; Piotr Karauda; Michał Polguj; Łukasz Olewnik
Background The subscapularis muscle originates from the medial two-thirds and from the lower two-thirds of the groove on the subscapular fossa of the scapula and inserts into the lesser tubercle of the humerus. Our initial hypothesis is that it shows little morphological variation. The aim of this study is to demonstrate and classify the morphological variability of the subscapularis muscle. Methods
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Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development Ann. Anat. (IF 2.388) Pub Date : 2020-10-21 Ping Zhang; Tingting Li; Chang Liu; Mustafa Sindi; Xin Cheng; Shuangyu Qi; Xinyue Liu; Yu Yan; Yongping Bao; Beate Brand-Saberi; Weidong Yang; Guang Wang; Xuesong Yang
Background 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyrimidine (PhIP), one of the most abundant heterocyclic aromatic amines (HAA) formed by cooking meat at high temperatures, may modify humans and rodents through the metabolic process prior to affecting nervous system development. In humans and rodents may be modified by metabolic processes and then affecting nervous system development. Methods In this
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Updates on congenital lacrimal drainage anomalies and their association with syndromes and systemic disorders: A major review Ann. Anat. (IF 2.388) Pub Date : 2020-10-21 Mohammad Javed Ali
Background To review and update the syndromic and non-syndromic systemic associations of congenital lacrimal drainage anomalies. Methods The authors performed a PubMed search of all articles published in English on congenital lacrimal drainage anomalies (CLDA). The current review provides an update from January 2017 to August 2020 on all CLDA associated with clinical syndromes or non-syndromic systemic
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Clinico-anatomical classification of the processus condylaris mandibulae for traumatological purposes Ann. Anat. (IF 2.388) Pub Date : 2020-10-21 Bartosz Bielecki-Kowalski; Marcin Kozakiewicz
Mandible condyle fracture has been reported to constitute 9–45 % (Asprino and Consani, 2006), 14.1 % (Bataineh, 1998), 25–50 % (Silvennoinen, Iizuka, 1992), 32 % (Chrcanovic et al., 2004), and 38 % (Brasileiro and Passeri, 2006) of all mandible fractures (Kozakiewicz and Swiniarski, 2013). Small bone segments, limited available space for application of the fixation material and limited visibility of
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The struggle to equilibrate outer and inner milieus: Renal evolution revisited Ann. Anat. (IF 2.388) Pub Date : 2020-10-13 Laura Keogh; David Kilroy; Sourav Bhattacharjee
The journey of life, from primordial protoplasm to a complex vertebrate form, is a tale of survival against incessant alterations in climate, surface topography, food chain, and chemistry of the external environment. Kidneys present with an ensemble embodiment of the adaptations devised by diverse life-forms to cope with such challenges and maintain a chemical equilibrium of water and solutes, both
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Characterization of the innervation of the meibomian glands in humans, rats and mice Ann. Anat. (IF 2.388) Pub Date : 2020-10-04 Maximilian Bründl; Fabian Garreis; Martin Schicht; Jana Dietricha; Friedrich Paulsen
Aim of the present study was to identify the nerve structures of meibomian glands in humans, rats and mice into sympathetic, parasympathetic and sensory parts as well as their topographical relation with regard to the gland architecture. The upper and lower eyelids of humans, rats and mice were examined by means of immunohistochemistry and indirect immunofluorescence. Specimen were investigated with
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Morphometric characteristics of anencephalic skulls–a comparative study Ann. Anat. (IF 2.388) Pub Date : 2020-10-04 Julia Schimp; Christian Dornia; Jochen Fanghänel; Peter Proff; Moritz Blanck-Lubarsch; Jens Weingärtner; Christian Kirschneck
Anencephaly is the most severe form of a neural tube defect resulting from the incomplete occlusion of the anterior neuropore in the fourth week of development and associated with a severely underdeveloped brain mass. As desmal ossification of the neurocranium is induced by the presence of soft tissues (brain), no bone develops as direct consequence of the missing brain. The cranial base, by contrast
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Human anatomy education and management of anatomic specimens during and after COVID-19 pandemic: Ethical, legal and biosafety aspects Ann. Anat. (IF 2.388) Pub Date : 2020-10-03 George Azevedo Lemos; Diego Neves Araújo; Fernando José Camello de Lima; Rodrigo Freitas Monte Bispo
COVID-19 is an infection caused by the SARS-CoV-2 virus, initially identified in the city of Wuhan, China, in December 2019. Since then, the virus has spread to the continents, causing a major pandemic. The impacts of this pandemic on the education of human anatomy interfere in at least two aspects: (1) receiving and managing anatomical specimens in anatomy laboratories and (2) adaptations for classes
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First-year health degree students in the dissection room: Analysis of adaptation to practical classes Ann. Anat. (IF 2.388) Pub Date : 2020-10-02 Esther Mingorance; Raquel Mayordomo; Ana María Pérez-Pico; Francisco Tirado; Yolanda Macías; Yolanda Gañán
Human anatomy is a core subject that students of all health degrees are required to pass. Practical classes with human cadavers are a widely used educational resource in medicine, but are less frequent in other health degrees. Determining how first-year podiatry, nursing, and physiotherapy students cope with human anatomy practical classes and identifying the presence of physical reactions and possible
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A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery Ann. Anat. (IF 2.388) Pub Date : 2020-09-28 Sarah E. Kinsley; Stephen D. Fernicola; Marvin E. Dingle; Milfred S. Williams; Jody M. Richardson; Dennis Taylor; Jaira F. de Vasconcellos; Timothy R. Malone; Matthew R. Blattner; Jonathan K. Smith; Alli Oliver; Amory L. Koch; Laura E. Riddle; Cara Reiter; William E. Culp; Edward J. Caterson; Leon J. Nesti; Simon G. Talbot
Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies
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Assessing the Perceptions of individuals with differing levels and backgrounds of education towards Whole-body Donation Ann. Anat. (IF 2.388) Pub Date : 2020-09-24 Jessi-Kate Viljoen; Shiby Stephens
Introduction The value of learning anatomy through cadaveric dissection is widely acclaimed; however, the demand for cadavers exceeds supply. For the number of donors to increase, there needs to be a broader understanding of what influences an individual’s perception towards whole-body donation. The hypotheses were that individuals with a biomedical background or with higher levels of education would
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Macrophage activating lipopeptide 2 is effective in mycobacterial lung infection. Ann. Anat. (IF 2.388) Pub Date : 2020-09-16 Thomas Tschernig,Reinhard Pabst
MALP-2, a synthetic lipopeptide is a Toll-like receptor 4 and -6 ligand and agonist. MALP-2 stimulates immune cells at different sites. Local stimulation in the lungs has beneficial effects in experimental pneumococci infection. The presented study investigated local effects of MALP-2 in the mycobacterial infection of lungs. MALP-2 was applied prior, simultaneously or after the pulmonary infection
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Effects of different bleaching application time on tooth color and mineral alteration. Ann. Anat. (IF 2.388) Pub Date : 2020-09-12 Zeyneb Merve Ozdemir,Derya Surmelioglu
Background The effects of HP-based products upon dental enamel are inconclusive. Purpose The purpose of this study was to evaluate the colour and mineral changes caused by the bleaching agent applications at different durations on the enamel surface. Basic Procedures 60 caries-free lower central incisor extracted for periodontal reasons were standardized for enamel and dentin thickness after cone-beam
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Characterization of natural killer cells in colorectal tumor tissue of rats fed a control diet or a high-fat diet. Ann. Anat. (IF 2.388) Pub Date : 2020-09-09 Ina Bähr,Ole Jannes Pörtner,Markus Glass,Henriette Doberstein,Vincent Goritz,Grit Gesine Ruth Hiller,Julia Spielmann,Heike Kielstein
Background Obesity is a major public health problem with an increasing prevalence reaching pandemic levels. The incidence and mortality for colorectal cancer is augmented in overweight and obese individuals. Previous studies demonstrated an impaired number, phenotype and functionality of natural killer (NK) cells under obese conditions. So far, the influence of obesity on NK cells in colorectal cancer
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Immunohistological analysis on distribution of smooth muscle tissues in livers of various vertebrates with attention to their different architectures. Ann. Anat. (IF 2.388) Pub Date : 2020-09-07 Noriaki Ota,Haruka Hirose,Hideaki Kato,Hikari Maeda,Nobuyoshi Shiojiri
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Corpses against science death: new Italian law titled 'Rules relating to the directives of one's body and tissues post-mortem for study, training, and scientific research purposes'. Ann. Anat. (IF 2.388) Pub Date : 2020-09-07 V Bolcato,P Braga,G Bini,G Belli,J Quaiotti,L P Tronconi,A M M Osculati
The new Italian Law no. 10 of 2020, titled ‘Rules relating to the directives of one’s body and tissues post-mortem for study, training, and scientific research purposes’ (10 February, 2020), has opened the doors to a new and clearer regimentation on body donation to science, according to the procedure already introduced by Law no. 219/2017 on the ‘Rules relating to informed consent and advance directives
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Topographical anatomy of the tentorium cerebelli and venous confluences in human midterm fetuses. Ann. Anat. (IF 2.388) Pub Date : 2020-09-06 Teruaki Oyanagi,Ji Hyun Kim,Masahito Yamamoto,Michitake Ishii,Gen Murakami,José Francisco Rodríguez-Vázquez,Shinichi Abe
Early development of veins and sinuses at and around the posterior cranial fossa seemed not to be shown by photographs except for our recent study (Ann Anat, 2020). Examination of histological sections of 38 fetuses at 10 to 16 weeks gestational age (GA) demonstrated that: 1) the superior petrosal sinus passed posterosuperiorly through the tentorium cerebelli and, distant and lateral to both the cerebellum
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"Suprascapular canal": Anatomical and topographical description and its clinical implication in entrapment syndrome. Ann. Anat. (IF 2.388) Pub Date : 2020-09-06 Azzat Al-Redouan,Keiv Holding,David Kachlik
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Relationship of segmental variations in the human lumbar plexus to the length of the 12th rib. Ann. Anat. (IF 2.388) Pub Date : 2020-09-06 Kounosuke Tokita,Hidaka Anetai,Ryuhei Kojima,Shyama Banneheka,Yukio Aizawa,Munekazu Naito,Takashi Nakano,Ikuo Kageyama,Katsuji Kumaki
Background Evaluating segmental variations in the lumbar plexus is crucial for neurological diagnosis. In the present study, we examined the relationship between the segmental composition of the lumbar plexus and length of the 12th rib. Procedures To evaluate segmental variations in the lumbar plexus, the furcal nerve (Nf) which forms the boundary between the lumbar and sacral plexus, was used as an
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Structural features of the anterior region of the mandible. Ann. Anat. (IF 2.388) Pub Date : 2020-09-03 Yuriy Vasil'ev,Friedrich Paulsen,Sergey Dydykin,Tatyana Bogoyavlenskaya,Artem Kashtanov
The research aims were to find out further intraosseous mandible organization indications and to structure it systematically. Material and methods : in our research 400 mandibles were used: for the intraosseous examinations in total 300 mandibles of persons aged 20–65 were used. For all corpses cephalic index was measured. Segmentation of the mandibles were made by Jigley saw between medial root of
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Anatomy of the bulbus vestibuli: A cadaveric study. Ann. Anat. (IF 2.388) Pub Date : 2020-09-02 Adam Ostrzenski
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Anatomy of the mandibular canal and surrounding structures. Part II: Cancellous pattern of the mandible. Ann. Anat. (IF 2.388) Pub Date : 2020-08-15 Joe Iwanaga,Koshi Shiromoto,Tomotaka Kato,Tsuyoshi Tanaka,Soichiro Ibaragi,R Shane Tubbs
Purpose It is necessary to correlate cancellous bone patterns with cone beam computed tomography (CBCT) images, but this has not been done to date. The goal of this study was to establish how the superior wall of the mandibular canal (MC) on CBCT images correlates with the cancellous bone around the MC on gross anatomical findings. Methods Twenty sides from 10 dry mandibles derived from six females
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A proposal for a new classification of soleus muscle morphology. Ann. Anat. (IF 2.388) Pub Date : 2020-08-15 Łukasz Olewnik,Nicol Zielinska,Friedrich Paulsen,Michał Podgórski,Robert Haładaj,Piotr Karauda,Michał Polguj
Introduction The soleus muscle (SM) is located in the superficial posterior compartment of the leg, together with the gastrocnemius muscle (GM) and plantaris muscle. There is little information on the morphological variability (pennation) of the SM. The aim of the study is to characterize the variations in the morphology of the pennation of the SM and to create the first accurate classification. Material
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Impact of NSAID etoricoxib on side effects of orthodontic tooth movement. Ann. Anat. (IF 2.388) Pub Date : 2020-08-18 Christian Kirschneck,Franziska Wolf,Fabian Cieplik,Moritz Blanck-Lubarsch,Peter Proff,Agnes Schröder
Objectives The non-steroidal anti-inflammatory drug etoricoxib is the most highly selective inhibitor of cyclooxygenase-2 available (344:1) and has been approved for postoperative pain therapy following dental interventions in Europe. At clinically relevant doses it has been reported to only have marginal effects on the velocity of orthodontic tooth movement (OTM). Its effects on associated dental
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The juxta-oral organ of Chievitz (organum yuxtaorale) updated: Embryology, anatomy, function and pathology. Ann. Anat. (IF 2.388) Pub Date : 2020-08-15 J Suárez-Quintanilla,J Martín-Cruces,B Martín-Biedma,J L Cobo,A J Mérida-García,J C de Vicente,L M Junquera,J R Mérida-Velasco,J A Vega
Background The Chievitz's organ or juxta-oral organ is a mysterious bilateral structure, phylogenetically preserved, which develops from the mouth epithelium as an invagination that loses connection to it in the prenatal period. It is located laterally to the walls of the oral cavity in an imprecise anatomical location and receives abundant innervation from the buccal nerve. Structurally it consists
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Impact of litter size on survival, growth and lung alveolarization of newborn mouse pups. Ann. Anat. (IF 2.388) Pub Date : 2020-07-18 Sophie Feddersen,Claudio Nardiello,Balachandar Selvakumar,István Vadász,Susanne Herold,Werner Seeger,Rory E Morty
Background Lung alveolarization, the development of the alveoli, is disturbed in preterm infants with bronchopulmonary dysplasia (BPD), the most common complication of preterm birth. Animal models based on oxygen toxicity to the developing mouse lung are used to understand the mechanisms of stunted alveolarization in BPD, and to develop new medical management strategies for affected infants. The toxicity
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The influence of alveolar bone healing degree on its potential as a source of human alveolar bone-derived cells. Ann. Anat. (IF 2.388) Pub Date : 2020-07-17 Eduardo Anitua,María Troya,Mar Zalduendo,Javier Flores,Roberto Tierno,Mohammad Hamdan Alkhraisat
Background The concept of bone tissue engineering has emerged as a novel alternative approach that comprises three essential components: osteogenic cells, osteoinductive signals and osteoconductive scaffolds. The low-speed drilling represents a useful and accessible autologous source for human alveolar bone-derived cells (hABCs). The aim of this study was to compare the efficacy of two donor sites
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The human costal cartilage: Anatomical and radiological study of macro-vascularization and micro-vascularization and its clinical relevance regarding vascularized chondrocostal free flap surgery. Ann. Anat. (IF 2.388) Pub Date : 2020-07-25 Jérémy Hardy,Sacha Chrosciany,Jean-Philippe Bernard,Christian Mabit,Pierre-Sylvain Marcheix
Introduction Cartilage repair usually involves in non-vascularized osteochondral or chondral grafts with some drawbacks potentially linked to the lack of vascular supply in those grafts. The aim of this study was to describe a surgical approach for harvesting a vascularized chondrocostal graft, to study the vascular supply to the perichondrium and finally to describe the perichondrium micro-vascularization