样式: 排序: IF: - GO 导出 标记为已读
-
Collective effects of cell cleavage dynamics Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-15 Magdalena Schindler-Johnson, Nicoletta I. Petridou
A conserved process of early embryonic development in metazoans is the reductive cell divisions following oocyte fertilization, termed cell cleavages. Cell cleavage cycles usually start synchronously, lengthen differentially between the embryonic cells becoming asynchronous, and cease before major morphogenetic events, such as germ layer formation and gastrulation. Despite exhibiting species-specific
-
One-step in vivo gene knock-out in porcine embryos using recombinant adeno-associated viruses Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-15 Mengyu Gao, YuTing He, XingLong Zhu, WanLiu Peng, YanYan Zhou, Yang Deng, Guangneng Liao, Wei Ni, Yi Li, Jun Gao, Hong Bu, Jiayin Yang, Guang Yang, Yang Yang, Ji Bao
Introduction: Gene-edited pigs have become prominent models for studying human disease mechanisms, gene therapy, and xenotransplantation. CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated 9 (CRISPR/Cas9) technology is a widely employed tool for generating gene-edited pigs. Nevertheless, delivering CRISPR/Cas9 to pre-implantation embryos has traditionally posed challenges
-
Diet-induced hyperhomocysteinemia causes sex-dependent deficiencies in offspring musculature and brain function Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-15 Joanna Suszyńska-Zajczyk, Łukasz Witucki, Joanna Perła-Kaján, Hieronim Jakubowski
Hyperhomocysteinemia (HHcy), characterized by elevated homocysteine (Hcy) levels, is a known risk factor for cardiovascular, renal, and neurological diseases, as well as pregnancy complications. Our study aimed to investigate whether HHcy induced by a high-methionine (high-Met) diet exacerbates cognitive and behavioral deficits in offspring and leads to other breeding problems. Dietary HHcy was induced
-
Functional analysis of a first hindlimb positioning enhancer via Gdf11 expression Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-15 Seiji Saito, Utsugi Kanazawa, Ayana Tatsumi, Atsuo Iida, Tatsuya Takemoto, Takayuki Suzuki
During the early development of tetrapods, including humans, the embryonic body elongates caudally once the anterior-posterior axis is established. During this process, region-specific vertebral morphogenesis occurs, with the determination of limb positioning along the anterior-posterior axis. We previously reported that Gdf11 functions as an anatomical integration system that determines the positioning
-
Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-15 Sanda Win, Tin Aung Than, Neil Kaplowitz
Cell death occurs in various circumstances, such as homeostasis, stress response, and defense, via specific pathways and mechanisms that are regulated by specific activator-induced signal transductions. Among them, Jun N-terminal kinases (JNKs) participate in various aspects, and the recent discovery of JNKs and mitochondrial protein SAB interaction in signal regulation of cell death completes our
-
Multi-omics analysis of TLCD1 as a promising biomarker in pan-cancer Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-15 Shengli Wang, Mingyue Zhang, Hongyan Sun, Tao Li, Jianlei Hao, Meixia Fang, Jie Dong, Hongbiao Xu
Background: The TLC Domain Containing 1 (TLCD1) protein, a key regulator of phosphatidylethanolamine (PE) composition, is distributed across several cellular membranes, including mitochondrial plasma membranes. Existing research has revealed the impact of TLCD1 on the development of non-alcoholic fatty liver disease. However, there remains a gap in comprehensive pan-cancer analyses of TLCD1, and the
-
Sensory cells in tunicates: insights into mechanoreceptor evolution Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-14
Tunicates, the sister group of vertebrates, offer a unique perspective for evolutionary developmental studies (Evo-Devo) due to their simple anatomical organization. Moreover, the separation of tunicates from vertebrates predated the vertebrate-specific genome duplications. As adults, they include both sessile and pelagic species, with very limited mobility requirements related mainly to water filtration
-
Sensory cells in tunicates: insights into mechanoreceptor evolution Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-14 Chiara Anselmi, Gwynna K. Fuller, Alberto Stolfi, Andrew K. Groves, Lucia Manni
Tunicates, the sister group of vertebrates, offer a unique perspective for evolutionary developmental studies (Evo-Devo) due to their simple anatomical organization. Moreover, the separation of tunicates from vertebrates predated the vertebrate-specific genome duplications. As adults, they include both sessile and pelagic species, with very limited mobility requirements related mainly to water filtration
-
Western diet-induced ultrastructural changes in mouse pancreatic acinar cells Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-14 Saška Lipovšek, Jurij Dolenšek, Barbara Dariš, Ismael Valladolid-Acebes, Tanja Vajs, Gerd Leitinger, Andraž Stožer, Maša Skelin Klemen
Mouse models of diet-induced type 2 diabetes mellitus provide powerful tools for studying the structural and physiological changes that are related to the disease progression. In this study, diabetic-like glucose dysregulation was induced in mice by feeding them a western diet, and light and transmission electron microscopy were used to study the ultrastructural changes in the pancreatic acinar cells
-
Nidogen in development and disease Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-14 Uwe Töpfer, Anne Holz
Nidogen, also known as entactin, is a multifunctional glycoprotein that plays a crucial role in the maintenance of the basement membrane (BM), morphogenesis and neuronal plasticity. This review aims to provide an overview of the structural features, molecular interactions and diverse functions associated with Nidogen. As a bridging molecule within the BM, Nidogen acts as a linchpin connecting various
-
Liver X Receptors (LXRs) in cancer-an Eagle’s view on molecular insights and therapeutic opportunities Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-14 Prasanna Srinivasan Ramalingam, Sujatha Elangovan, Janaki Ramaiah Mekala, Sivakumar Arumugam
Cancer has become a serious health burden that results in high incidence and mortality rates every year, mainly due to various molecular alterations inside the cell. Liver X receptors (LXRs) dysregulation is one among them that plays a vital role in cholesterol metabolism, lipid metabolism and inflammation and also plays a crucial role in various diseases such as obesity, metabolic dysfunction-associated
-
Stable knockdown of Drp1 improves retinoic acid-BDNF-induced neuronal differentiation through global transcriptomic changes and results in reduced phosphorylation of ERK1/2 independently of DUSP1 and 6 Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-14 Marvi Ghani, Peleg Zohar, Gyula Ujlaki, Melinda Tóth, Hailemariam Amsalu, Szilárd Póliska, Krisztina Tar
Background: Dynamin-related protein Drp1 —a major mitochondrial fission protein— is widely distributed in the central nervous system and plays a crucial role in regulating mitochondrial dynamics, specifically mitochondrial fission and the organelle's shaping. Upregulated Drp1 function may contribute to the pathological progression of neurodegenerative diseases by dysregulating mitochondrial fission/
-
Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-13 Sun-Ah Lee, Gi-Ju Cho, Doyoung Kim, Dong-Hwee Kim
Mechanical properties of the tumor microenvironment play a critical role in cancer progression by activation of cancer mechano-responses. The biophysical interactions between cancer cells and their dynamic microenvironment are attributed to force-dependent alterations in molecular pathways that trigger the structural reorganization of intracellular organelles and their associated genetic modifications
-
MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-13 Baike Chen, Yuxin Zhang, Ousheng Liu
Modeling and remodeling are essential processes in the development and refinement of maxillofacial bones. Dysregulated bone modeling during the developmental stage may lead to maxillofacial bone malformations and malocclusion. Bone remodeling under mechanical loading serves as the biological basis for orthodontic treatment. Although previous reviews have indicated the significance of microRNAs (miRNAs)
-
Early onset of APC/C activity renders SAC inefficient in mouse embryos Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-13 Adela Horakova, Marketa Konecna, Lenka Radonova, Martin Anger
Control mechanisms of spindle assembly and chromosome segregation are vital for preventing aneuploidy during cell division. The mammalian germ cells and embryos are prone to chromosome segregation errors, and the resulting aneuploidy is a major cause of termination of development or severe developmental disorders. Here we focused on early mouse embryos, and using combination of methods involving microinjection
-
Exploring the neuroprotective activity of a lignanamides-rich extract in human neuroblastoma SH-SY5Y cells under dimethyl sulfoxide-induced stress Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-13 Marta Mallardo, Severina Pacifico, Simona Piccolella, Irene Di Meo, Maria Rosaria Rizzo, Aurora Daniele, Ersilia Nigro
Introduction: Dimethyl sulfoxide (DMSO) is widely used as a diluent and/or solvent for pharmacological compounds. Furthermore, DMSO crosses the blood-brain barrier acting on the nervous system. The natural compounds phenylamides and lignanamides (LnHS) have protective effects on neuronal health, being promising neuroprotective candidates. In this scenario, we evaluated the impact of DMSO and/or LnHS
-
Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-13 Qianzi Liu, Linxi Lv, Xueding Cai, Jiandong Zhu, Jifa Li, Lehe Yang, Xiaona Xie, Chengguang Zhao, Haiyang Zhao
N6-methyladenosine (m6A) is the most abundant chemical modification in eukaryotic cells. It is a post-transcriptional modification of mRNA, a dynamic reversible process catalyzed by methyltransferase, demethylase, and binding proteins. Ferroptosis, a unique iron-dependent cell death, is regulated by various cell metabolic events, including many disease-related signaling pathways. And different ferroptosis
-
Gene expression and cellular changes in injured myocardium of Ciona intestinalis Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-13 Serenity Stokes, Pooja Pardhanani Palmer, Jeremy L. Barth, Robert L. Price, Bella G. Parker, Heather J. Evans Anderson
Ciona intestinalis is an invertebrate animal model system that is well characterized and has many advantages for the study of cardiovascular biology. The regulatory mechanisms of cardiac myocyte proliferation in Ciona are intriguing since regeneration of functional tissue has been demonstrated in other organs of Ciona in response to injury. To identify genes that are differentially expressed in response
-
Multiplexing of TMT labeling reveals folate-deficient diet-specific proteome changes in NTDs Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-13 Pei Pei, Jinying Shen, Xuejia He, Yubing Zeng, Ting Zhang, Shan Wang
Introduction: In the early stage of embryonic development, the neural tube (NT) cannot be closed properly due to some complex factors, including environmental factors, genetic factors, and the relationship between various factors, leading to the occurrence of neural tube defects (NTDs).Methods: In this study, we induced a mouse model of NTDs by feeding mice with a low-folate diet and intraperitoneally
-
Novel lipid mediator 7S,14R-docosahexaenoic acid: biogenesis and harnessing mesenchymal stem cells to ameliorate diabetic mellitus and retinal pericyte loss Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-12 Yan Lu, Haibin Tian, Hongying Peng, Quansheng Wang, Bruce A. Bunnell, Nicolas G. Bazan, Song Hong
Introduction: Stem cells can be used to treat diabetic mellitus and complications. ω3-docosahexaenoic acid (DHA) derived lipid mediators are inflammation-resolving and protective. This study found novel DHA-derived 7S,14R-dihydroxy-4Z,8E,10Z,12E,16Z,19Z-docosahexaenoic acid (7S,14R-diHDHA), a maresin-1 stereoisomer biosynthesized by leukocytes and related enzymes. Moreover, 7S,14R-diHDHA can enhance
-
Gene networks and the evolution of olfactory organs, eyes, hair cells and motoneurons: a view encompassing lancelets, tunicates and vertebrates Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-12 Bernd Fritzsch, Joel C. Glover
Key developmental pathways and gene networks underlie the formation of sensory cell types and structures involved in chemosensation, vision and mechanosensation, and of the efferents these sensory inputs can activate. We describe similarities and differences in these pathways and gene networks in selected species of the three main chordate groups, lancelets, tunicates, and vertebrates, leading to divergent
-
Membrane trafficking alterations in breast cancer progression Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-12 Andreia Ferreira, Pedro Castanheira, Cristina Escrevente, Duarte C. Barral, Teresa Barona
Breast cancer (BC) is the most common type of cancer in women, and remains one of the major causes of death in women worldwide. It is now well established that alterations in membrane trafficking are implicated in BC progression. Indeed, membrane trafficking pathways regulate BC cell proliferation, migration, invasion, and metastasis. The 22 members of the ADP-ribosylation factor (ARF) and the >60
-
Superior migration ability of umbilical cord-derived mesenchymal stromal cells (MSCs) toward activated lymphocytes in comparison with those of bone marrow and adipose-derived MSCs Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-11 Akiko Hori, Atsuko Takahashi, Yuta Miharu, Satoru Yamaguchi, Masatoshi Sugita, Takeo Mukai, Fumitaka Nagamura, Tokiko Nagamura-Inoue
Introduction: Mesenchymal stromal cells (MSCs) are activated upon inflammation and/or tissue damage and migrate to suppress inflammation and repair tissues. Migration is the first important step for MSCs to become functional; however, the migration potency of umbilical cord-derived MSCs (UC-MSCs) remains poorly understood. Thus, we aimed to assess the migration potency of UC-MSCs in comparison with
-
Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-11 Hideko Utsumi, Taijiro Yabe, Sumito Koshida, Akira Yamashita, Shinji Takada
To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may cause such contacts to be temporarily weakened, risking improper development and maintenance of tissues. Despite such risks, tissues form properly during
-
The epithelium takes the stage in asthma and inflammatory bowel diseases Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-11 Rocío López-Posadas, Dustin C. Bagley, Carlos Pardo-Pastor, Elena Ortiz-Zapater
The epithelium is a dynamic barrier and the damage to this epithelial layer governs a variety of complex mechanisms involving not only epithelial cells but all resident tissue constituents, including immune and stroma cells. Traditionally, diseases characterized by a damaged epithelium have been considered “immunological diseases,” and research efforts aimed at preventing and treating these diseases
-
Direct male development in chromosomally ZZ zebrafish Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-11 Catherine A. Wilson, Peter Batzel, John H. Postlethwait
The genetics of sex determination varies across taxa, sometimes even within a species. Major domesticated strains of zebrafish (Danio rerio), including AB and TU, lack a strong genetic sex determining locus, but strains more recently derived from nature, like Nadia (NA), possess a ZZ male/ZW female chromosomal sex-determination system. AB fish pass through a juvenile ovary stage, forming oocytes that
-
Identification of testis development-related genes by combining Iso-Seq and RNA-Seq in Zeugodacus tau Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-11 Peipei Liu, Ziniu Li, Qiuyuan Zhang, Jiao Qiao, Chenjun Zheng, Wenping Zheng, Hongyu Zhang
Introduction:Zeugodacus tau (Walker) is an invasive pest. An effective method to control this pest is the sterile insect technique (SIT). To better apply this technique, it is necessary to understand testis development progression.Methods: Differentially expressed genes (DEGs) during testis development were analyzed by PacBio Iso-Seq and RNA-seq.Results: RNA-Seq library of Z. tau testes on day 1, 6
-
Morphology of the immune cells in the wall of the human uterine tube and their possible impact on reproduction—uterine tube as a possible immune privileged organ Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-09 Kristína Visnyaiová, Ivan Varga, Claudia Feitscherová, Lada Pavlíková, Jozef Záhumenský, Renáta Mikušová
The uterine tube, as well as other parts of the upper female reproductive system, is immunologically unique in its requirements for tolerance to allogenic sperm and semi-allogenic embryos, yet responds to an array of sexually transmitted pathogens. To understand this dichotomy, there is a need to understand the functional morphology of immune cells in the wall of the uterine tube. Thus, we reviewed
-
Cellular abundance-based prognostic model associated with deregulated gene expression of leukemic stem cells in acute myeloid leukemia Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-08 Dong-Jin Han, Sunmin Kim, Seo-Young Lee, Su Jung Kang, Youngbeen Moon, Hoon Seok Kim, Myungshin Kim, Tae-Min Kim
Background: Previous studies have reported that genes highly expressed in leukemic stem cells (LSC) may dictate the survival probability of patients and expression-based cellular deconvolution may be informative in forecasting prognosis. However, whether the prognosis of acute myeloid leukemia (AML) can be predicted using gene expression and deconvoluted cellular abundances is debatable.Methods: Nine
-
Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-08 Ramcharan Singh Angom, Adita Joshi, Ashok Patowary, Ambily Sivadas, Soundhar Ramasamy, Shamsudheen K. V., Kriti Kaushik, Ankit Sabharwal, Mukesh Kumar Lalwani, Subburaj K., Naresh Singh, Vinod Scaria, Sridhar Sivasubbu
LncRNA-based control affects cardiac pathophysiologies like myocardial infarction, coronary artery disease, hypertrophy, and myotonic muscular dystrophy. This study used a gene-break transposon (GBT) to screen zebrafish (Danio rerio) for insertional mutagenesis. We identified three insertional mutants where the GBT captured a cardiac gene. One of the adult viable GBT mutants had bradycardia (heart
-
Communication molecules (ncRNAs) mediate tumor-associated macrophage polarization and tumor progression Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-08 Min Yao, Xuhua Mao, Zherui Zhang, Feilun Cui, Shihe Shao, Boneng Mao
Non-coding RNAs play important roles in tumor cells and macrophages and participate in their communication as messengers. Non-coding RNAs have an impact in tumor cell proliferation, migration, and apoptosis, and they also regulate the differentiation and regulation of immune cells. In macrophages, they stimulate the polarization of macrophages into M1 or M2 by regulating proteins related to signaling
-
Oocyte and embryo culture under oil profoundly alters effective concentrations of small molecule inhibitors Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-07 Gaudeline Rémillard-Labrosse, Sydney Cohen, Éliane Boucher, Kéryanne Gagnon, Filip Vasilev, Aleksandar I. Mihajlović, Greg FitzHarris
Culture of oocytes and embryos in media under oil is a cornerstone of fertility treatment, and extensively employed in experimental investigation of early mammalian development. It has been noted anecdotally by some that certain small molecule inhibitors might lose activity in oil-covered culture systems, presumably by drug partitioning into the oil. Here we took a pseudo-pharmacological approach to
-
NEST3D printed bone-mimicking scaffolds: assessment of the effect of geometrical design on stiffness and angiogenic potential Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-07 Stephanie E. Doyle, Micaela Pannella, Carmine Onofrillo, Chiara Bellotti, Claudia Di Bella, Cathal D. O’Connell, Elena Pirogova, Enrico Lucarelli, Serena Duchi
Tissue-engineered implants for bone regeneration require consideration regarding their mineralization and vascularization capacity. Different geometries, such as biomimetic designs and lattices, can influence the mechanical properties and the vascularization capacity of bone-mimicking implants. Negative Embodied Sacrificial Template 3D (NEST3D) printing is a versatile technique across a wide range
-
Parallel evolution of gravity sensing Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-06 Daria Y. Romanova, Leonid L. Moroz
Omnipresent gravity affects all living organisms; it was a vital factor in the past and the current bottleneck for future space exploration. However, little is known about the evolution of gravity sensing and the comparative biology of gravity reception. Here, by tracing the parallel evolution of gravity sensing, we encounter situations when assemblies of homologous modules result in the emergence
-
Interaction between immuno-stem dual lineages in jaw bone formation and injury repair Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-06 Ziyi Liu, Xutao Luo, Ruoshi Xu
The jawbone, a unique structure in the human body, undergoes faster remodeling than other bones due to the presence of stem cells and its distinct immune microenvironment. Long-term exposure of jawbones to an oral environment rich in microbes results in a complex immune balance, as shown by the higher proportion of activated macrophage in the jaw. Stem cells derived from the jawbone have a higher propensity
-
Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-06 Shira N. Johnston, Maria Tsingas, Rahatul Ain, Ruteja A. Barve, Makarand V. Risbud
Hypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nucleus pulposus (NP) cells, consequences of elevated HIF-2 activity on disc health remains unknown. We expressed HIF-2α with proline to alanine substitutions (P405A; P531A) in the Oxygen-dependent degradation domain (HIF-2αdPA) in the NP tissue using an inducible, nucleus pulposus-specific
-
MYC: there is more to it than cancer Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-06 Mariano F. Zacarías-Fluck, Laura Soucek, Jonathan R. Whitfield
MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular proliferation, differentiation, metabolism, ribogenesis, and bone and vascular development. Over 4 decades of research and some 10,000 publications linking it to tumorigenesis (by searching PubMed for “MYC oncogene”)
-
Ehrlichia chaffeensis TRP120 ubiquitinates tumor suppressor APC to modulate Hippo and Wnt signaling Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-05 Caitlan D. Byerly, Bing Zhu, Paityn A. Warwick, LaNisha L. Patterson, Nicholas A. Pittner, Jere W. McBride
Ehrlichia chaffeensis: TRP120 is a multifunctional effector that acts as a ligand mimic to activate evolutionary conserved eukaryotic signaling pathways Notch, Wnt, Hedgehog and Hippo. In addition, TRP120 is also a HECT E3 ubiquitin ligase known to ubiquitinate several host cell regulatory proteins (FBW7, PCGF5 and ENO-1) for degradation. We previously determined that TRP120 ubiquitinates the Notch
-
Research advances of polycomb group proteins in regulating mammalian development Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-05 Yan Li, Yanxiang Mo, Chen Chen, Jin He, Zhiheng Guo
Polycomb group (PcG) proteins are a subset of epigenetic factors that are highly conserved throughout evolution. In mammals, PcG proteins can be classified into two muti-proteins complexes: Polycomb repressive complex 1 (PRC1) and PRC2. Increasing evidence has demonstrated that PcG complexes play critical roles in the regulation of gene expression, genomic imprinting, chromosome X-inactivation, and
-
Roles of endogenous retroviral elements in the establishment and maintenance of imprinted gene expression Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-05 Sherry Fang, Kai-Wei Chang, Louis Lefebvre
DNA methylation (DNAme) has long been recognized as a host defense mechanism, both in the restriction modification systems of prokaryotes as well as in the transcriptional silencing of repetitive elements in mammals. When DNAme was shown to be implicated as a key epigenetic mechanism in the regulation of imprinted genes in mammals, a parallel with host defense mechanisms was drawn, suggesting perhaps
-
Primary sarcopenia is associated with elevated spontaneous NET formation Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-05 Irina Balazs, Manuel Stelzer, Julia Traub, Angela Horvath, Nicole Feldbacher, Vanessa Stadlbauer
Introduction: Sarcopenia is a frequent complication of liver cirrhosis, but it can also occur independently as a result of any underlying cause. The immune system plays an important role in the pathogenesis of both liver cirrhosis and sarcopenia. Neutrophil function, including neutrophil extracellular trap (NET) formation, is linked to chronic inflammation; however, it has not been extensively studied
-
Proton-sensing ion channels, GPCRs and calcium signaling regulated by them: implications for cancer Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-05 Renhui Ji, Li Chang, Caiyan An, Junjing Zhang
Extracellular acidification of tumors is common. Through proton-sensing ion channels or proton-sensing G protein-coupled receptors (GPCRs), tumor cells sense extracellular acidification to stimulate a variety of intracellular signaling pathways including the calcium signaling, which consequently exerts global impacts on tumor cells. Proton-sensing ion channels, and proton-sensing GPCRs have natural
-
Developmental outcome of electroencephalographic findings in SYNGAP1 encephalopathy Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-05 Juliana Ribeiro-Constante, Alba Tristán-Noguero, Fernando Francisco Martínez Calvo, Salvador Ibañez-Mico, José Luis Peña Segura, José Miguel Ramos-Fernández, María del Carmen Moyano Chicano, Rafael Camino León, Víctor Soto Insuga, Elena González Alguacil, Carlos Valera Dávila, Alberto Fernández-Jaén, Laura Plans, Ana Camacho, Nuria Visa-Reñé, María del Pilar Martin-Tamayo Blázquez, Fernando Paredes-Carmona
SYNGAP1 haploinsufficiency results in a developmental and epileptic encephalopathy (DEE) causing generalized epilepsies accompanied by a spectrum of neurodevelopmental symptoms. Concerning interictal epileptiform discharges (IEDs) in electroencephalograms (EEG), potential biomarkers have been postulated, including changes in background activity, fixation-off sensitivity (FOS) or eye closure sensitivity
-
Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-04 Hua Su, Chao Peng, Yang Liu
The global challenge posed by cancer, marked by rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. The PI3K/Akt signaling pathway, frequently amplified in various cancers, is central in regulating essential cellular processes. Its dysregulation, often stemming from genetic mutations, significantly contributes to cancer initiation, progression, and resistance
-
Basal endothelial glycocalyx’s response to shear stress: a review of structure, function, and clinical implications Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-04 Zoe Vittum, Samantha Cocchiaro, Solomon A. Mensah
The endothelial glycocalyx encompasses the entire endothelial cell, transducing extracellular signals and regulating vascular permeability and barrier functions. The apical glycocalyx, which forms the lumen of the vessel, and the basal glycocalyx, at the smooth muscle cell interface, are often investigated separately as they are exposed to vastly different stimuli. The apical glycocalyx directly senses
-
Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-04 Sayumi Tahara, Soumya Sharma, Fernanda Costas Casal de Faria, Patricia Sarchet, Luisa Tomasello, Sydney Rentsch, Roma Karna, Federica Calore, Raphael E. Pollock
Background: Dedifferentiated liposarcoma is a formidable sarcoma subtype due to its high local recurrence rate and resistance to medical treatment. While 2D cell cultures are still commonly used, 3D cell culture systems have emerged as a promising alternative, particularly scaffold-based techniques that enable the creation of 3D models with more accurate cell-stroma interactions.Objective: To investigate
-
High-resolution 3D ultrastructural analysis of developing mouse neocortex reveals long slender processes of endothelial cells that enter neural cells Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-04 Michaela Wilsch-Bräuninger, Jula Peters, Wieland B. Huttner
The development of the neocortex involves an interplay between neural cells and the vasculature. However, little is known about this interplay at the ultrastructural level. To gain a 3D insight into the ultrastructure of the developing neocortex, we have analyzed the embryonic mouse neocortex by serial block-face scanning electron microscopy (SBF-SEM). In this study, we report a first set of findings
-
Cell-cell interaction in the pathogenesis of inherited retinal diseases Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-04 Xue Du, Anna G. Butler, Holly Y. Chen
The retina is part of the central nervous system specialized for vision. Inherited retinal diseases (IRD) are a group of clinically and genetically heterogenous disorders that lead to progressive vision impairment or blindness. Although each disorder is rare, IRD accumulatively cause blindness in up to 5.5 million individuals worldwide. Currently, the pathophysiological mechanisms of IRD are not fully
-
Cell type-specific regulation of CFTR trafficking—on the verge of progress Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-04 Carlos M. Farinha, Lúcia Santos, João F. Ferreira
Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is a complex process that starts with its biosynthesis and folding in the endoplasmic reticulum. Exit from the endoplasmic reticulum (ER) is coupled with the acquisition of a compact structure that can be processed and traffic through the secretory pathway. Once reaching its final destination—the plasma membrane,
-
Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-01 Sarah J. Harmych, Claiborne W. Tydings, Jens Meiler, Bhuminder Singh
Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane proteins. The trafficking of these proteins is directed by short amino acid sequences known as sorting motifs. In six basolaterally-localized proteins lacking the canonical tyrosine- and dileucine-based basolateral sorting motifs, a monoleucine-based sorting motif has been identified
-
The role of mitochondria in eosinophil function: implications for severe asthma pathogenesis Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-01 Janice Koranteng, Kian Fan Chung, Charalambos Michaeloudes, Pankaj Bhavsar
Mitochondria are key metabolic hubs involved in cellular energy production and biosynthesis. ATP is generated primarily by glucose and fatty acid oxidation through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) in the mitochondria. During OXPHOS there is also production of reactive oxygen species (ROS), which are involved in the regulation of cellular function. Mitochondria
-
Effects of a humanized CD47 antibody and recombinant SIRPα proteins on triple negative breast carcinoma stem cells Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-01 Sukhbir Kaur, Bianca Reginauld, Sam Razjooyan, Trung Phi, Satya P. Singh, Thomas J. Meyer, Margaret C. Cam, David D. Roberts
Signal regulatory protein-α (SIRPα, SHPS-1, CD172a) expressed on myeloid cells transmits inhibitory signals when it engages its counter-receptor CD47 on an adjacent cell. Elevated CD47 expression on some cancer cells thereby serves as an innate immune checkpoint that limits phagocytic clearance of tumor cells by macrophages and antigen presentation to T cells. Antibodies and recombinant SIRPα constructs
-
Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-03-01 Rebecca M. Crossley, Samuel Johnson, Erika Tsingos, Zoe Bell, Massimiliano Berardi, Margherita Botticelli, Quirine J. S. Braat, John Metzcar, Marco Ruscone, Yuan Yin, Robyn Shuttleworth
The extracellular matrix (ECM) is a highly complex structure through which biochemical and mechanical signals are transmitted. In processes of cell migration, the ECM also acts as a scaffold, providing structural support to cells as well as points of potential attachment. Although the ECM is a well-studied structure, its role in many biological processes remains difficult to investigate comprehensively
-
Timeless–Tipin interactions with MCM and RPA mediate DNA replication stress response Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-02-29 Paulina Prorok, Eva Wolf, M. Cristina Cardoso
The accuracy of replication is one of the most important mechanisms ensuring the stability of the genome. The fork protection complex prevents premature replisome stalling and/or premature disassembly upon stress. Here, we characterize the Timeless–Tipin complex, a component of the fork protection complex. We used microscopy approaches, including colocalization analysis and proximity ligation assay
-
Neural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-02-29 Francisca Cornejo, Nayhara Franchini, Bastián I. Cortés, Daniela Elgueta, Gonzalo I. Cancino
Neurodevelopmental disorders are characterized by alterations in the development of the cerebral cortex, including aberrant changes in the number and function of neural cells. Although neurogenesis is one of the most studied cellular processes in these pathologies, little evidence is known about glial development. Genetic association studies have identified several genes associated with neurodevelopmental
-
A developmental atlas of male terminalia across twelve species of Drosophila Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-02-29 Anna Urum, Gavin Rice, William Glassford, Yifat Yanku, Boris Shklyar, Mark Rebeiz, Ella Preger-Ben Noon
How complex morphologies evolve is one of the central questions in evolutionary biology. Observing the morphogenetic events that occur during development provides a unique perspective on the origins and diversification of morphological novelty. One can trace the tissue of origin, emergence, and even regression of structures to resolve murky homology relationships between species. Here, we trace the
-
Spontaneous signal generation by an excitable system for cell migration Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-02-28 Satomi Matsuoka, Koji Iwamoto, Da Young Shin, Masahiro Ueda
Eukaryotic cells exhibit random migration in the absence of extracellular directional cues. This random migration acts as basal motility for various migratory responses such as chemotaxis. The self-organization of random motility requires the internal signals that determine the anterior side of the migrating cell be generated spontaneously from the intrinsic activities of intracellular signaling networks
-
Cyclodextrin derivatives decrease Transient Receptor Potential vanilloid 1 and Ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-02-28 Andrea Kinga Nehr-Majoros, János Erostyák, Éva Fenyvesi, Edina Szabó-Meleg, Levente Szőcs, György Sétáló, Zsuzsanna Helyes, Éva Szőke
Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are nonselective cation channels expressed in primary sensory neurons and several other non-neuronal structures such as immune cells, keratinocytes, and vascular smooth muscle cells. They play important roles in nociception, pain processing and their chanellopathies are associated with the development of several pathological conditions
-
Generation of heterozygous and homozygous NF1 lines from human-induced pluripotent stem cells using CRISPR/Cas9 to investigate bone defects associated with neurofibromatosis type 1 Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-02-28 Annabelle Darle, Thibault Mahiet, Déborah Aubin, Manon Doyen, Lina El Kassar, Béatrice Parfait, Gilles Lemaitre, Christine Baldeschi, Jennifer Allouche, Nathalie Holic
Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders caused by heterozygous germline NF1 mutations. NF1 affects many systems, including the skeletal system. To date, no curative therapies are available for skeletal manifestations such as scoliosis and tibial dysplasia, mainly due to the lack of knowledge about the mechanisms that underlie this process. By using CRISPR/Cas9-mediated
-
Ferroptosis and its current progress in gastric cancer Front. Cell Dev. Biol. (IF 5.5) Pub Date : 2024-02-28 Zhenqi Yue, Yiwu Yuan, Qi Zhou, Jie Sheng, Lin Xin
Gastric Cancer (GC) is a prevalent malignancy within the digestive tract, ranking as the fifth most common malignant tumor worldwide. It is characterized by clinical features such as a tendency for metastasis and an unfavorable prognosis. Ferroptosis, a recently identified form of cell death, represents a novel mode of cellular demise that diverges from the traditional concepts of necrosis and apoptosis