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Use of priming strategies to advance the clinical application of mesenchymal stromal/stem cell-based therapy. World J. Stem Cells (IF 4.1) Pub Date : 2024-1-31 Vitale Miceli
Mesenchymal stromal/stem cells (MSCs) have garnered significant attention in the field of regenerative medicine due to their remarkable therapeutic potential. MSCs play a pivotal role in maintaining tissue homeostasis and possess diverse functions in tissue repair and recovery in various organs. These cells are characterized by easy accessibility, few ethical concerns, and adaptability to in vitro
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Application of mesenchymal stem cell therapy for premature ovarian insufficiency: Recent advances from mechanisms to therapeutics. World J. Stem Cells (IF 4.1) Pub Date : 2024-1-31 Hang-Qi Hu, Xi-Yan Xin, Yu-Tian Zhu, Rui-Wen Fan, Hao-Lin Zhang, Yang Ye, Dong Li
The incidence of premature ovarian insufficiency (POI) is increasing worldwide, particularly among younger women, posing a significant challenge to fertility. In addition to menopausal symptoms, POI leads to several complications that profoundly affect female reproductive function and overall health. Unfortunately, current clinical treatment strategies for this condition are limited and often yield
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Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study. World J. Stem Cells (IF 4.1) Pub Date : 2024-1-31 Erdinç Civelek, Serdar Kabatas, Eyüp Can Savrunlu, Furkan Diren, Necati Kaplan, Demet Ofluoğlu, Erdal Karaöz
Peripheral nerve injury can result in significant clinical complications that have uncertain prognoses. Currently, there is a lack of effective pharmacological interventions for nerve damage, despite the existence of several small compounds, peptides, hormones, and growth factors that have been suggested as potential enhancers of neuron regeneration. Despite the objective of achieving full functional
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Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives. World J. Stem Cells (IF 4.1) Pub Date : 2024-1-31 Hong-Shuo Shi, Xin Yuan, Fang-Fang Wu, Xiao-Yu Li, Wei-Jing Fan, Xiao Yang, Xiao-Ming Hu, Guo-Bin Liu
Stem cell therapy has shown great potential for treating diabetic foot (DF).
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Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial. World J. Stem Cells (IF 4.1) Pub Date : 2024-1-5 Cong-Zi Wu, Zhen-Yu Shi, Zhen Wu, Wen-Jun Lin, Wei-Bo Chen, Xue-Wen Jia, Si-Cheng Xiang, Hui-Hui Xu, Qin-Wen Ge, Kai-Ao Zou, Xu Wang, Jia-Li Chen, Ping-Er Wang, Wen-Hua Yuan, Hong-Ting Jin, Pei-Jian Tong
Osteoarthritis (OA) is the most prevalent form of degenerative whole-joint disease. Before the final option of knee replacement, arthroscopic surgery was the most widely used joint-preserving surgical treatment. Emerging regenerative therapies, such as those involving platelet-rich plasma, mesenchymal stem cells, and microfragmented adipose tissue (MFAT), have been pushed to the forefront of treatment
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ADSC-Exos outperform BMSC-Exos in alleviating hydrostatic pressure-induced injury to retinal ganglion cells by upregulating nerve growth factors. World J. Stem Cells (IF 4.1) Pub Date : 2024-1-5 Zhi-Kun Zheng, Lei Kong, Min Dai, Yi-Dan Chen, Yan-Hua Chen
Mesenchymal stem cells (MSCs) have protective effects on the cornea, lacrimal gland, retina, and photoreceptor cell damage, which may be mediated by exosomes (exos) released by MSCs.
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Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment. World J. Stem Cells (IF 4.1) Pub Date : 2024-1-5 Ejlal Abu-El-Rub, Fatimah Almahasneh, Ramada R Khasawneh, Ayman Alzu'bi, Doaa Ghorab, Rawan Almazari, Huthaifa Magableh, Ahmad Sanajleh, Haitham Shlool, Mohammad Mazari, Noor S Bader, Joud Al-Momani
Mesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases. Diabetes mellitus (DM) is a frequently diagnosed chronic disease characterized by hyperglycemia which initiates many multisystem complications in the long-run. DM patients can benefit from MSCs transplantation to curb down the pathological consequences
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Stem cells and pain. World J. Stem Cells (IF 4.1) Pub Date : 2024-1-5 Matheus Deroco Veloso da Silva, Maiara Piva, Geovana Martelossi-Cebinelli, Mariana Stinglin Rosa Ribas, Beatriz Hoffmann Salles Bianchini, Olivia K Heintz, Rubia Casagrande, Waldiceu A Verri
Pain can be defined as an unpleasant sensory and emotional experience caused by either actual or potential tissue damage or even resemble that unpleasant experience. For years, science has sought to find treatment alternatives, with minimal side effects, to relieve pain. However, the currently available pharmacological options on the market show significant adverse events. Therefore, the search for
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Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications. World J. Stem Cells (IF 4.1) Pub Date : 2023-10-26 Wen-Bo Xing,Shu-Ting Wu,Xin-Xin Wang,Fen-Yao Li,Ruo-Xuan Wang,Ji-Hui He,Jiao Fu,Yan He
Peripheral nerve injury (PNI) seriously affects people's quality of life. Stem cell therapy is considered a promising new option for the clinical treatment of PNI. Dental stem cells, particularly dental pulp stem cells (DPSCs), are adult pluripotent stem cells derived from the neuroectoderm. DPSCs have significant potential in the field of neural tissue engineering due to their numerous advantages
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MicroRNA-584-5p/RUNX family transcription factor 2 axis mediates hypoxia-induced osteogenic differentiation of periosteal stem cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-10-26 Jia-Jia Lu,Xiao-Jian Shi,Qiang Fu,Yong-Chuan Li,Lei Zhu,Nan Lu
BACKGROUND The hypoxic environment during bone healing is important in regulating the differentiation of periosteal stem cells (PSCs) into osteoblasts or chondrocytes; however, the underlying mechanisms remain unclear. AIM To determine the effect of hypoxia on PSCs, and the expression of microRNA-584-5p (miR-584-5p) and RUNX family transcription factor 2 (RUNX2) in PSCs was modulated to explore the
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Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque. World J. Stem Cells (IF 4.1) Pub Date : 2023-09-26 Hai-Juan Hu,Xue-Ru Xiao,Tong Li,De-Min Liu,Xue Geng,Mei Han,Wei Cui
BACKGROUND Umbilical cord (UC) mesenchymal stem cell (MSC) transplantation is a potential therapeutic intervention for atherosclerotic vascular disease. Integrin beta 3 (ITGB3) promotes cell migration in several cell types. However, whether ITGB-modified MSCs can migrate to plaque sites in vivo and play an anti-atherosclerotic role remains unclear. AIM To investigate whether ITGB3-overexpressing MSCs
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Interferon-γ priming enhances the therapeutic effects of menstrual blood-derived stromal cells in a mouse liver ischemia-reperfusion model. World J. Stem Cells (IF 4.1) Pub Date : 2023-09-26 Qi Zhang,Si-Ning Zhou,Jia-Min Fu,Li-Jun Chen,Yang-Xin Fang,Zhen-Yu Xu,Hui-Kang Xu,Yin Yuan,Yu-Qi Huang,Ning Zhang,Yi-Fei Li,Charlie Xiang
BACKGROUND Mesenchymal stem cells (MSCs) have been used in liver transplantation and have certain effects in alleviating liver ischemia-reperfusion injury (IRI) and regulating immune rejection. However, some studies have indicated that the effects of MSCs are not very significant. Therefore, approaches that enable MSCs to exert significant and stable therapeutic effects are worth further study. AIM
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Enhanced wound healing and hemostasis with exosome-loaded gelatin sponges from human umbilical cord mesenchymal stem cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-09-26 Xin-Mei Hu,Can-Can Wang,Yu Xiao,Peng Jiang,Yu Liu,Zhong-Quan Qi
BACKGROUND Rapid wound healing remains a pressing clinical challenge, necessitating studies to hasten this process. A promising approach involves the utilization of human umbilical cord mesenchymal stem cells (hUC-MSCs) derived exosomes. The hypothesis of this study was that these exosomes, when loaded onto a gelatin sponge, a common hemostatic material, would enhance hemostasis and accelerate wound
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Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis. World J. Stem Cells (IF 4.1) Pub Date : 2023-09-26 Lu Lv,En-Hai Cui,Bin Wang,Li-Qin Li,Feng Hua,Hua-Dong Lu,Na Chen,Wen-Yan Chen
BACKGROUND Acute lung injury (ALI) and its final severe stage, acute respiratory distress syndrome, are associated with high morbidity and mortality rates in patients due to the lack of effective specific treatments. Gut microbiota homeostasis, including that in ALI, is important for human health. Evidence suggests that the gut microbiota improves lung injury through the lung-gut axis. Human umbilical
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Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure. World J. Stem Cells (IF 4.1) Pub Date : 2023-09-26 Lei Wang,Jin-Jin Zhang,Sha-Sha Wang,Liang Li
BACKGROUND Heart failure (HF) is a global health problem characterized by impaired heart function. Cardiac remodeling and cell death contribute to the development of HF. Although treatments such as digoxin and angiotensin receptor blocker drugs have been used, their effectiveness in reducing mortality is uncertain. Researchers are exploring the use of adipose-derived mesenchymal stem cell (ADMSC) exosomes
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Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis. World J. Stem Cells (IF 4.1) Pub Date : 2023-9-13 Wen-Jie Zhao, Xin Liu, Man Hu, Yu Zhang, Peng-Zhi Shi, Jun-Wu Wang, Xu-Hua Lu, Xiao-Fei Cheng, Yu-Ping Tao, Xin-Min Feng, Yong-Xiang Wang, Liang Zhang
Intervertebral disc degeneration (IDD) is a main contributor to low back pain. Oxidative stress, which is highly associated with the progression of IDD, increases senescence of nucleus pulposus-derived mesenchymal stem cells (NPMSCs) and weakens the differentiation ability of NPMSCs in degenerated intervertebral discs (IVDs). Quercetin (Que) has been demonstrated to reduce oxidative stress in diverse
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Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo. World J. Stem Cells (IF 4.1) Pub Date : 2023-9-13 Rabbia Muneer, Rida-E-Maria Qazi, Abiha Fatima, Waqas Ahmad, Asmat Salim, Luciana Dini, Irfan Khan
Cardiovascular diseases particularly myocardial infarction (MI) are the leading cause of mortality and morbidity around the globe. As cardiac tissue possesses very limited regeneration potential, therefore use of a potent small molecule, inhibitor Wnt production-4 (IWP-4) for stem cell differentiation into cardiomyocytes could be a promising approach for cardiac regeneration. Wnt pathway inhibitors
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Mastering the craft: Creating an insightful and widely-cited literature review. World J. Stem Cells (IF 4.1) Pub Date : 2023-9-13 Shengwen Calvin Li
The art of constructing an insightful literature review manuscript has witnessed an exemplar in the work of Oz et al (2023), wherein concept progression harmoniously merges with figures and tables. Reflecting on retrospective data science, it is evident that well-cited articles can wield a transformative influence on the Journal Citation Reports Impact Factor score, as exemplified by Robert Weinberg's
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Up-to-date meta-analysis of long-term evaluations of mesenchymal stem cell therapy for complex perianal fistula. World J. Stem Cells (IF 4.1) Pub Date : 2023-9-13 Fang Cheng, Huang Zhong, Zhong Huang, Zhi Li
Local mesenchymal stem cell (MSC) therapy for complex perianal fistulas (PFs) has shown considerable promise. But, the long-term safety and efficacy of MSC therapy in complex PFs remain unknown.
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Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-9-13 Jing Huang, Yi-Ning Wang, Yi Zhou
Bone marrow mesenchymal stromal cells (BMSCs) are the commonly used seed cells in tissue engineering. Aryl hydrocarbon receptor (AhR) is a transcription factor involved in various cellular processes. However, the function of constitutive AhR in BMSCs remains unclear.
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Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cord-derived mesenchymal stem cells by increasing PD-L1 expression. World J. Stem Cells (IF 4.1) Pub Date : 2023-9-13 Zhuo Chen, Meng-Wei Yao, Zhi-Lin Shen, Shi-Dan Li, Wei Xing, Wei Guo, Zhan Li, Xiao-Feng Wu, Luo-Quan Ao, Wen-Yong Lu, Qi-Zhou Lian, Xiang Xu, Xiang Ao
The immunosuppressive capacity of mesenchymal stem cells (MSCs) is dependent on the "license" of several proinflammatory factors to express immunosuppressive factors such as programmed cell death 1 ligand 1 (PD-L1), which determines the clinical therapeutic efficacy of MSCs for inflammatory or immune diseases. In MSCs, interferon-gamma (IFN-γ) is a key inducer of PD-L1 expression, which is synergistically
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Neural stem cells for Parkinson's disease management: Challenges, nanobased support, and prospects. World J. Stem Cells (IF 4.1) Pub Date : 2023-07-26 Tuba Oz,Ajeet Kaushik,Małgorzata Kujawska
Parkinson's disease (PD), characterized by loss of nigrostriatal dopaminergic neurons, is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide. The concept of stem cell therapy in managing neurodegenerative diseases has evolved over the years and has recently rapidly progressed. Neural stem cells (NSCs) have a few key features, including self-renewal, proliferation
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Commitment of human mesenchymal stromal cells to skeletal lineages is independent of their morphogenetic capacity. World J. Stem Cells (IF 4.1) Pub Date : 2023-07-26 Jessica Cristina Marín-Llera,Damián García-García,Estefania Garay-Pacheco,Victor Adrian Cortes-Morales,Juan Jose Montesinos-Montesinos,Jesus Chimal-Monroy
BACKGROUND Mesenchymal stromal cells (MSCs) are multipotent cell populations obtained from fetal and adult tissues. They share some characteristics with limb bud mesodermal cells such as differentiation potential into osteogenic, chondrogenic, and tenogenic lineages and an embryonic mesodermal origin. Although MSCs differentiate into skeletal-related lineages in vitro, they have not been shown to self-organize
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Transplantation of human induced pluripotent stem cell derived keratinocytes accelerates deep second-degree burn wound healing. World J. Stem Cells (IF 4.1) Pub Date : 2023-07-26 Li-Jun Wu,Wei Lin,Jian-Jiang Liu,Wei-Xin Chen,Wen-Jun He,Yuan Shi,Xiao Liu,Ke Li
BACKGROUND Current evidence shows that human induced pluripotent stem cells (hiPSCs) can effectively differentiate into keratinocytes (KCs), but its effect on skin burn healing has not been reported. AIM To observe the effects of hiPSCs-derived KCs transplantation on skin burn healing in mice and to preliminarily reveal the underlying mechanisms. METHODS An analysis of differentially expressed genes
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Generation of a human haploid neural stem cell line for genome-wide genetic screening. World J. Stem Cells (IF 4.1) Pub Date : 2023-07-26 Hai-Song Wang,Xin-Rui Ma,Wen-Bin Niu,Hao Shi,Yi-Dong Liu,Ning-Zhao Ma,Nan Zhang,Zi-Wei Jiang,Ying-Pu Sun
BACKGROUND Haploid embryonic stem cells (haESCs) have been established in many species. Differentiated haploid cell line types in mammals are lacking due to spontaneous diploidization during differentiation that compromises lineage-specific screens. AIM To derive human haploid neural stem cells (haNSCs) to carry out lineage-specific screens. METHODS Human haNSCs were differentiated from human extended
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Zinc enhances the cell adhesion, migration, and self-renewal potential of human umbilical cord derived mesenchymal stem cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-07-26 Iqra Sahibdad,Shumaila Khalid,G Rasul Chaudhry,Asmat Salim,Sumreen Begum,Irfan Khan
BACKGROUND Zinc (Zn) is the second most abundant trace element after Fe, present in the human body. It is frequently reported in association with cell growth and proliferation, and its deficiency is considered to be a major disease contributing factor. AIM To determine the effect of Zn on in vitro growth and proliferation of human umbilical cord (hUC)-derived mesenchymal stem cells (MSCs). METHODS
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Could extracellular vesicles derived from mesenchymal stem cells be a potential therapy for acute pancreatitis-induced cardiac injury? World J. Stem Cells (IF 4.1) Pub Date : 2023-07-26 Long-Fei Pan,Ze-Qun Niu,Song Ren,Hong-Hong Pei,Yan-Xia Gao,Hui Feng,Jiang-Li Sun,Zheng-Liang Zhang
Acute pancreatitis (AP) often leads to a high incidence of cardiac injury, posing significant challenges in the treatment of severe AP and contributing to increased mortality rates. Mesenchymal stem cells (MSCs) release bioactive molecules that participate in various inflammatory diseases. Similarly, extracellular vesicles (EVs) secreted by MSCs have garnered extensive attention due to their comparable
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Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche. World J. Stem Cells (IF 4.1) Pub Date : 2023-07-26 Guo-Kun Zhang,Jing Ren,Ji-Ping Li,Dong-Xu Wang,Sheng-Nan Wang,Li-Yan Shi,Chun-Yi Li
BACKGROUND Scar formation and loss of cutaneous appendages are the greatest challenges in cutaneous wound healing. Previous studies have indicated that antler reserve mesenchyme (RM) cells and their conditioned medium improved regenerative wound healing with partial recovery of cutaneous appendages. AIM To develop hydrogels from the antler RM matrix (HARM) and evaluate the effect on wound healing.
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Human retinal secretome: A cross-link between mesenchymal and retinal cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-07-26 Luigi Donato,Concetta Scimone,Simona Alibrandi,Sergio Zaccaria Scalinci,Domenico Mordà,Carmela Rinaldi,Rosalia D'Angelo,Antonina Sidoti
In recent years, mesenchymal stem cells (MSC) have been considered the most effective source for regenerative medicine, especially due to released soluble paracrine bioactive components and extracellular vesicles. These factors, collectively called the secretome, play crucial roles in immunomodulation and in improving survival and regeneration capabilities of injured tissue. Recently, there has been
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Adipokines regulate mesenchymal stem cell osteogenic differentiation. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Zhong-Hua Xu,Chen-Wei Xiong,Kai-Song Miao,Zhen-Tang Yu,Jun-Jie Zhang,Chang-Lin Yu,Yong Huang,Xin-Die Zhou
Mesenchymal stem cells (MSCs) can differentiate into various tissue cell types including bone, adipose, cartilage, and muscle. Among those, osteogenic differentiation of MSCs has been widely explored in many bone tissue engineering studies. Moreover, the conditions and methods of inducing osteogenic differentiation of MSCs are continuously advancing. Recently, with the gradual recognition of adipokines
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Neural lineage differentiation of human pluripotent stem cells: Advances in disease modeling. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Yuan-Wei Yan,Eddie S Qian,Lauren E Woodard,Julie Bejoy
Brain diseases affect 1 in 6 people worldwide. These diseases range from acute neurological conditions such as stroke to chronic neurodegenerative disorders such as Alzheimer's disease. Recent advancements in tissue-engineered brain disease models have overcome many of the different shortcomings associated with the various animal models, tissue culture models, and epidemiologic patient data that are
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Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Arielly da Hora Alves,Mariana Penteado Nucci,Nicole Mastandrea Ennes do Valle,Juliana Morais Missina,Javier Bustamante Mamani,Gabriel Nery Albuquerque Rego,Olivia Furiama Metropolo Dias,Murilo Montenegro Garrigós,Fernando Anselmo de Oliveira,Lionel Fernel Gamarra
BACKGROUND Induced pluripotent stem cells (iPSCs) show great ability to differentiate into any tissue, making them attractive candidates for pathophysiological investigations. The rise of organ-on-a-chip technology in the past century has introduced a novel way to make in vitro cell cultures that more closely resemble their in vivo environments, both structural and functionally. The literature still
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Advances of nanotechnology applied to cancer stem cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Miao Yue,Ting Guo,Deng-Yun Nie,Yin-Xing Zhu,Mei Lin
Cancer stem cells (CSCs) are a small proportion of the cells that exist in cancer tissues. They are considered to be the culprit of tumor genesis, development, drug resistance, metastasis and recurrence because of their self-renewal, proliferation, and differentiation potential. The elimination of CSCs is thus the key to cure cancer, and targeting CSCs provides a new method for tumor treatment. Due
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Single cell RNA sequencing reveals mesenchymal heterogeneity and critical functions of Cd271 in tooth development. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Yan-Yan Zhang,Feng Li,Xiao-Ke Zeng,Yan-Hui Zou,Bing-Bing Zhu,Jia-Jia Ye,Yun-Xiao Zhang,Qiu Jin,Xin Nie
BACKGROUND Accumulating evidence suggests that the maxillary process, to which cranial crest cells migrate, is essential to tooth development. Emerging studies indicate that Cd271 plays an essential role in odontogenesis. However, the underlying mechanisms have yet to be elucidated. AIM To establish the functionally heterogeneous population in the maxillary process, elucidate the effects of Cd271 deficiency
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Factors affecting osteogenesis and chondrogenic differentiation of mesenchymal stem cells in osteoarthritis. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Yi Peng,Hai Jiang,Hou-Dong Zuo
Osteoarthritis (OA) is a common degenerative joint disease that often involves progressive cartilage degeneration and bone destruction of subchondral bone. At present, clinical treatment is mainly for pain relief, and there are no effective methods to delay the progression of the disease. When this disease progresses to the advanced stage, the only treatment option for most patients is total knee replacement
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Clinical relevance of stem cells in lung cancer. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Horacio Eduardo Romeo,María Laura Barreiro Arcos
Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung cancer (SCLC) and non-SCLC (NSCLC). In turn, NSCLC is categorized into three distinct cell subtypes: Adenocarcinoma, squamous cell carcinoma, and large cell carcinoma
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Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Qiong-Dan Hu,Rui-Zhi Tan,Yuan-Xia Zou,Jian-Chun Li,Jun-Ming Fan,Fahsai Kantawong,Li Wang
BACKGROUND Bone marrow-derived mesenchymal stem cells (MSCs) show podocyte-protective effects in chronic kidney disease. Calycosin (CA), a phytoestrogen, is isolated from Astragalus membranaceus with a kidney-tonifying effect. CA preconditioning enhances the protective effect of MSCs against renal fibrosis in mice with unilateral ureteral occlusion. However, the protective effect and underlying mechanism
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Potential regulatory effects of stem cell exosomes on inflammatory response in ischemic stroke treatment. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Na Chen,Yan-Lin Wang,Hui-Fang Sun,Zhuo-Ya Wang,Qi Zhang,Fei-Yan Fan,Yu-Cheng Ma,Fei-Xiang Liu,Yun-Ke Zhang
The high incidence and disability rates of stroke pose a heavy burden on society. Inflammation is a significant pathological reaction that occurs after an ischemic stroke. Currently, therapeutic methods, except for intravenous thrombolysis and vascular thrombectomy, have limited time windows. Mesenchymal stem cells (MSCs) can migrate, differentiate, and inhibit inflammatory immune responses. Exosomes
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Culture and identification of neonatal rat brain-derived neural stem cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-06-26 Qing-Zhong Zhou,Xiao-Lan Feng,Xu-Feng Jia,Nurul Huda Binti Mohd Nor,Mohd Hezery Bin Harun,Da-Xiong Feng,Wan Aliaa Wan Sulaiman
BACKGROUND Timing of passaging, passage number, passaging approaches and methods for cell identification are critical factors influencing the quality of neural stem cells (NSCs) culture. How to effectively culture and identify NSCs is a continuous interest in NSCs study while these factors are comprehensively considered. AIM To establish a simplified and efficient method for culture and identification
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Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Jia-Qi Zhou,Hao-Yang Wan,Zi-Xuan Wang,Nan Jiang
Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. It is usually considered that the differentiation process of MSCs depends on specialized external stimulating factors, including cell signaling pathways, cytokines, and other physical stimuli. Recent findings have revealed other underrated roles in the
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How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 María Belén Novoa Díaz,Pedro Carriere,Claudia Gentili
Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics. It is well established that the appearance of distal metastasis in CRC patients is the cause of a poor prognosis and treatment failure. Nevertheless, in the last decades, CRC aggressiveness and progression have been attributed to a specific
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Tissue-specific cancer stem/progenitor cells: Therapeutic implications. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Amani Yehya,Joe Youssef,Sana Hachem,Jana Ismael,Wassim Abou-Kheir
Surgical resection, chemotherapy, and radiation are the standard therapeutic modalities for treating cancer. These approaches are intended to target the more mature and rapidly dividing cancer cells. However, they spare the relatively quiescent and intrinsically resistant cancer stem cells (CSCs) subpopulation residing within the tumor tissue. Thus, a temporary eradication is achieved and the tumor
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Molecular signaling in cancer stem cells of tongue squamous cell carcinoma: Therapeutic implications and challenges. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Priyanka Joshi,Sanjeev Waghmare
Head and neck squamous cell carcinoma is the seventh most common cancer worldwide with high mortality rates. Amongst oral cavity cancers, tongue carcinoma is a very common and aggressive oral cavity carcinoma. Despite the implementation of a multimodality treatment regime including surgical intervention, chemo-radiation as well as targeted therapy, tongue carcinoma shows a poor overall 5-year survival
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Stromal cell-derived factor-1α regulates chondrogenic differentiation via activation of the Wnt/β-catenin pathway in mesenchymal stem cells. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Xiao Chen,Xia-Ming Liang,Jia Zheng,Yong-Hui Dong
BACKGROUND Mesenchymal stem cells (MSCs) have been applied to treat degenerative articular diseases, and stromal cell-derived factor-1α (SDF-1α) may enhance their therapeutic efficacy. However, the regulatory effects of SDF-1α on cartilage differentiation remain largely unknown. Identifying the specific regulatory effects of SDF-1α on MSCs will provide a useful target for the treatment of degenerative
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Cell transplantation therapies for spinal cord injury focusing on bone marrow mesenchymal stem cells: Advances and challenges. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Li-Yi Huang,Xin Sun,Hong-Xia Pan,Lu Wang,Cheng-Qi He,Quan Wei
Spinal cord injury (SCI) is a devastating condition with complex pathological mechanisms that lead to sensory, motor, and autonomic dysfunction below the site of injury. To date, no effective therapy is available for the treatment of SCI. Recently, bone marrow-derived mesenchymal stem cells (BMMSCs) have been considered to be the most promising source for cellular therapies following SCI. The objective
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Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Vitale Miceli,Giovanni Zito,Matteo Bulati,Alessia Gallo,Rosalia Busà,Gioacchin Iannolo,Pier Giulio Conaldi
Mesenchymal stromal/stem cells (MSCs) have shown significant therapeutic potential, and have therefore been extensively investigated in preclinical studies of regenerative medicine. However, while MSCs have been shown to be safe as a cellular treatment, they have usually been therapeutically ineffective in human diseases. In fact, in many clinical trials it has been shown that MSCs have moderate or
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Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: Impact on disease progression. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Daniel García-Sánchez,Alberto González-González,Ana Alfonso-Fernández,Mónica Del Dujo-Gutiérrez,Flor M Pérez-Campo
Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow (BM). The interaction between MM cells and the BM microenvironment, and specifically BM mesenchymal stem cells (BM-MSCs), has a key role in the pathophysiology of this disease. Multiple data support the idea that BM-MSCs not only enhance the proliferation
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Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Zhi Wang,Cheng Feng,Hao Liu,Tian Meng,Wei-Qing Huang,Ke-Xin Song,You-Bin Wang
BACKGROUND Wound healing impairment is a dysfunction induced by hyperglycemia and its effect on endothelial precursor cells (EPCs) in type 2 diabetes mellitus. There is increasing evidence showing that exosomes (Exos) derived from adipose-derived mesenchymal stem cells (ADSCs) exhibit the potential to improve endothelial cell function along with wound healing. However, the potential therapeutic mechanism
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Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Żaneta Kałuzińska-Kołat,Damian Kołat,Katarzyna Kośla,Elżbieta Płuciennik,Andrzej K Bednarek
Literature data on glioblastoma ongoingly underline the link between metabolism and cancer stemness, the latter is one responsible for potentiating the resistance to treatment, inter alia due to increased invasiveness. In recent years, glioblastoma stemness research has bashfully introduced a key aspect of cytoskeletal rearrangements, whereas the impact of the cytoskeleton on invasiveness is well known
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Human pluripotent stem cell-derived extracellular vesicles: From now to the future. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Bruno Moises de Matos,Marco Augusto Stimamiglio,Alejandro Correa,Anny Waloski Robert
Extracellular vesicles (EVs) are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools. Accordingly, in various biological contexts, EVs are reported to engage in immune modulation, senescence, and cell proliferation and differentiation. Therefore, EVs could be key elements for potential off-the-shelf cell-free therapy.
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Modulation of stem cell fate in intestinal homeostasis, injury and repair. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Zhe Wang,Yan-Ji Qu,Min Cui
The mammalian intestinal epithelium constitutes the largest barrier against the external environment and makes flexible responses to various types of stimuli. Epithelial cells are fast-renewed to counteract constant damage and disrupted barrier function to maintain their integrity. The homeostatic repair and regeneration of the intestinal epithelium are governed by the Lgr5+ intestinal stem cells (ISCs)
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Advancements in adipose-derived stem cell therapy for skin fibrosis. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Yu-Xin Liu,Jia-Ming Sun,Chia-Kang Ho,Ya Gao,Dong-Sheng Wen,Yang-Dan Liu,Lu Huang,Yi-Fan Zhang
Pathological scarring and scleroderma, which are the most common conditions of skin fibrosis, pathologically manifest as fibroblast proliferation and extracellular matrix (ECM) hyperplasia. Fibroblast proliferation and ECM hyperplasia lead to fibrotic tissue remodeling, causing an exaggerated and prolonged wound-healing response. The pathogenesis of these diseases has not been fully clarified and is
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Single-cell RNA sequencing in cornea research: Insights into limbal stem cells and their niche regulation. World J. Stem Cells (IF 4.1) Pub Date : 2023-05-26 Di Sun,Wei-Yun Shi,Sheng-Qian Dou
The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. Its continuous renewal or wound healing depends on the proliferation and differentiation of limbal stem cells (LSCs), a cell population that resides at the limbus in a highly regulated niche. Dysfunction of LSCs or
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Role of brahma-related gene 1/brahma-associated factor subunits in neural stem/progenitor cells and related neural developmental disorders. World J. Stem Cells (IF 4.1) Pub Date : 2023-04-26 Nai-Yu Ke,Tian-Yi Zhao,Wan-Rong Wang,Yu-Tong Qian,Chao Liu
Different fates of neural stem/progenitor cells (NSPCs) and their progeny are determined by the gene regulatory network, where a chromatin-remodeling complex affects synergy with other regulators. Here, we review recent research progress indicating that the BRG1/BRM-associated factor (BAF) complex plays an important role in NSPCs during neural development and neural developmental disorders. Several
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Obesity and cancer stem cells: Roles in cancer initiation, progression and therapy resistance. World J. Stem Cells (IF 4.1) Pub Date : 2023-04-26 Wen-Jie Xie,Jian Li
Obesity, the global pandemic since industrialization, is the number one lifestyle-related risk factor for premature death, which increases the incidence and mortality of various diseases and conditions, including cancer. In recent years, the theory of cancer stem cells (CSCs), which have the capacity for self-renewal, metastasis and treatment resistance, has been bolstered by increasing evidence. However
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Extracellular vesicles: Emerged as a promising strategy for regenerative medicine. World J. Stem Cells (IF 4.1) Pub Date : 2023-04-26 Dian-Ri Wang,Jian Pan
Cell transplantation therapy has certain limitations including immune rejection and limited cell viability, which seriously hinder the transformation of stem cell-based tissue regeneration into clinical practice. Extracellular vesicles (EVs) not only possess the advantages of its derived cells, but also can avoid the risks of cell transplantation. EVs are intelligent and controllable biomaterials that
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Mechanisms of analgesic effect of mesenchymal stem cells in osteoarthritis pain. World J. Stem Cells (IF 4.1) Pub Date : 2023-04-26 Fatimah Almahasneh,Ejlal Abu-El-Rub,Ramada R Khasawneh
Osteoarthritis (OA) is the most common musculoskeletal disease, and it is a major cause of pain, disability and health burden. Pain is the most common and bothersome presentation of OA, but its treatment is still suboptimal, due to the short-term action of employed analgesics and their poor adverse effect profile. Due to their regenerative and anti-inflammatory properties, mesenchymal stem cells (MSCs)
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Banking of perinatal mesenchymal stem/stromal cells for stem cell-based personalized medicine over lifetime: Matters arising. World J. Stem Cells (IF 4.1) Pub Date : 2023-04-26 Cheng-Hai Li,Jing Zhao,Hong-Yan Zhang,Bin Wang
Mesenchymal stromal/stem cells (MSCs) are currently applied in regenerative medicine and tissue engineering. Numerous clinical studies have indicated that MSCs from different tissue sources can provide therapeutic benefits for patients. MSCs derived from either human adult or perinatal tissues have their own unique advantages in their medical practices. Usually, clinical studies are conducted by using
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Repetitive administration of cultured human CD34+ cells improve adenine-induced kidney injury in mice. World J. Stem Cells (IF 4.1) Pub Date : 2023-04-26 Takayasu Ohtake,Shoichi Itaba,Amankeldi A Salybekov,Yin Sheng,Tsutomu Sato,Mitsuru Yanai,Makoto Imagawa,Shigeo Fujii,Hiroki Kumagai,Masamitsu Harata,Takayuki Asahara,Shuzo Kobayashi
BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease (CKD). AIM To examine the efficacy of cultured human CD34+ cells with enhanced proliferating potential in kidney injury in mice. METHODS Human umbilical cord blood (UCB)-derived CD34+ cells were incubated for one week in vasculogenic conditioning medium. Vasculogenic culture
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Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases. World J. Stem Cells (IF 4.1) Pub Date : 2023-04-26 Chao Yang,Xin-Ya Du,Wen Luo
Since dental pulp stem cells (DPSCs) were first reported, six types of dental SCs (DSCs) have been isolated and identified. DSCs originating from the craniofacial neural crest exhibit dental-like tissue differentiation potential and neuro-ectodermal features. As a member of DSCs, dental follicle SCs (DFSCs) are the only cell type obtained at the early developing stage of the tooth prior to eruption