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Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-14
Abstract Previous studies have implicated targeting Pim-1 proto-oncogene, serine/threonine kinase (PIM1) as a preventive measure against high glucose–induced cellular stress and apoptosis. This study aimed to reveal the potential role and regulatory mechanism of PIM1 in diabetic retinopathy. Human retinal microvascular endothelial cells (hRMECs) underwent high glucose induction, and fluctuations in
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Programmed cell death-1-modified pig developed using electroporation-mediated gene editing for in vitro fertilized zygotes In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-14 Thanh-Van Nguyen, Lanh Thi Kim Do, Qingyi Lin, Megumi Nagahara, Zhao Namula, Manita Wittayarat, Maki Hirata, Takeshige Otoi, Fuminori Tanihara
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Ginsenoside Rg1 relieves rat intervertebral disc degeneration and inhibits IL-1β-induced nucleus pulposus cell apoptosis and inflammation via NF-κB signaling pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-14 Lei Yu, Ying-Jie Hao, Zhi-Nan Ren, Guang-Duo Zhu, Wei-Wei Zhou, Xu Lian, Xue-Jian Wu
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Secondary Publication: Proposal for Points of Consideration for Pluripotent Stem Cell Culture In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-12
Abstract Human pluripotent stem cells, such as human embryonic stem cells and human induced pluripotent stem cells, are used in basic research and various applied fields, including drug discovery and regenerative medicine. Stem cell technologies have developed rapidly in recent years, and the supply of culture materials has improved. This has facilitated the culture of human pluripotent stem cells
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CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-04 Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhen
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Human embryonic stem cells maintain their stemness in three-dimensional microenvironment In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-04 Jasmeet Kaur Virdi, Prasad Pethe
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Serum starvation is as efficient as roscovitine on the cycle synchronization in G0/G1 of red-rumped agouti fibroblasts In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-01 Érika Almeida Praxedes, Lhara Ricarliany Medeiros de Oliveira, João Vitor da Silva Viana, Luanna Lorenna Vieira Rodrigues, José de Brito Vieira Neto, Sarah Leyenne Alves Sales, Maria Claudia dos Santos Luciano, Moacir Franco de Oliveira, Cláudia Pessoa, Alexsandra Fernandes Pereira
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Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-29 Mingfa Ling, Heying Qian, Huiduo Guo
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Long-term preservation of established fibroblast lines from six‐banded armadillos (Euphractus sexcintus, Linnaeus, 1758) by extended passage and cryopreservation In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-29 Denilsa Pires Fernandes, Érika Almeida Praxedes, João Vitor da Silva Viana, Maria Valéria de Oliveira Santos, Alexandre Rodrigues Silva, Carlos Iberê Alves Freitas, Alexsandra Fernandes Pereira
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Adiponectin attenuates H2O2-induced apoptosis in chicken skeletal myoblasts through the lysosomal-mitochondrial axis In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-26 Han Wang, Chi Li, Longbo Zhu, Zhengqun Liu, Ning Li, Zi Zheng, Shiyue Liang, Jun Yan
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Preclinical assessments of safety and tumorigenicity of very high doses of allogeneic human umbilical cord mesenchymal stem cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-29 Sze-Piaw Chin, Nik Syazana Saffery, Kong-Yong Then, Soon-Keng Cheong
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Characterization and establishment of an immortalized rabbit ovary granulosa cell line for reproductive biology experiments In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-28 Zhiyuan Bao, Yang Chen, Jiali Li, Jiawei Cai, Bohao Zhao, Xinsheng Wu
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The effect of bta-miR-1296 on the proliferation and extracellular matrix synthesis of bovine mammary fibroblasts In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-26 Yuejie Yang, Tao Yuan, Rui Wu, Zijian Geng, Shuai Lian, Jianfa Wang
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TGFβ2 mediates oxidative stress–induced epithelial-to-mesenchymal transition of bladder smooth muscle In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-26 Jingwen Geng, Xiaofan Zhang, Yansong Zhang, Xiaojia Meng, Jinqi Sun, Bo Zhou, Jun Ma
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The origins of human pluripotent stem cells: the road from a cancer to regenerative medicine In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-23 Peter W. Andrews
The notion of using pluripotent stem cells (PSCs) as a source of differentiated cell types for replacement of disease or damaged tissues in regenerative medicine is now an active area of research, with approaches to treating eye diseases such as age-related macular degeneration or Parkinson’s disease now on the horizon. But the foundations for this research lie in a quite different area of science
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WAY-262611 ameliorates the inflammatory bowel disease by activating Wnt/β-catenin pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-23
Abstract Inflammatory bowel disease (IBD) is a non-specific and relapsing intestinal inflammation. The injury and repair of intestinal epithelial together determine the occurrence and development of IBD. Wnt/β-catenin pathway is considered as the key role in the proliferation and differentiation of intestinal stem cells which is negative regulated by Dickkiop (DKKs). WAY-262611 is a novel inhibitor
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Generation of chimpanzee induced pluripotent stem cell lines for cross-species comparisons In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-22 Masanori Imamura, Risako Nakai, Mari Ohnuki, Yusuke Hamazaki, Hideyuki Tanabe, Momoka Sato, Yu Harishima, Musashi Horikawa, Mao Watanabe, Hiroki Oota, Masato Nakagawa, Shunsuke Suzuki, Wolfgang Enard
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New insights in ubiquitin-dependent Wnt receptor regulation in tumorigenesis In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-21 Tadasuke Tsukiyama
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Wnt/β-catenin signaling pathway in liver biology and tumorigenesis In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-20 Shinji Matsumoto, Akira Kikuchi
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Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-20 Thanh-Van Nguyen, Koki Takebayashi, Lanh Thi Kim Do, Zhao Namula, Manita Wittayarat, Megumi Nagahara, Maki Hirata, Takeshige Otoi, Fuminori Tanihara
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Understanding and manipulating extracellular behaviors of Wnt ligands In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-20 Yusuke Mii
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Avoiding aggregation of human bone marrow–derived mesenchymal stem cells stored in cell preservation solutions In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-15 Takeshi Kikuchi, Masuhiro Nishimura, Chikage Shirakawa, Yasutaka Fujita, Takeshige Otoi
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The interplay between Wnt signaling pathways and microtubule dynamics Wnt signaling, microtubule dynamics In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-13 Koji Kikuchi, Masaki Arata
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REMOVER-PITCh: microhomology-assisted long-range gene replacement with highly multiplexed CRISPR-Cas9 In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-09
Abstract A variety of CRISPR-Cas9-based gene editing technologies have been developed, including gene insertion and gene replacement, and applied to the study and treatment of diseases. While numerous studies have been conducted to improve the efficiency of gene insertion and to expand the system in various ways, there have been relatively few reports on gene replacement technology; therefore, further
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DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-29 Xinxin Liu, Zhou Ye, Dingyu Rao, Qianshun Chen, Zuxiong Zhang
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Dihydrotanshinone I reduces H9c2 cell damage by regulating AKT and MAPK signaling pathways In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-22 Ya-chao Wang, Yi-da Shao, Chang-le Shao, Xiao-qi Guan, Ping-ping Lu, Ke Ning, Bao-nian Liu, Hai-dong Guo
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Administration with curcumin alleviates spinal cord ischemia-reperfusion injury by regulating anti-oxidative stress and microglia activation-mediated neuroinflammation via Nrf2/NF-κB axis In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-16 Fengchun Wu, Yu Lin, Lili Xiao, Qiyong Chen, Fengfei Lin, Renbin Li
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Modulating effect of Eunkyo-san on expression of inflammatory cytokines and angiotensin-converting enzyme 2 in human mast cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-16
Abstract Eunkyo-san is widely used in the treatment of severe respiratory infections. Mast cells not only serve as host cells for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also they also exacerbate Coronavirus disease in 2019 (COVID-19) by causing a cytokine storm. Here we investigated whether Eunkyo-san and its active compound naringenin regulate the expression of inflammatory
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Bilirubin impairs neuritogenesis and synaptogenesis in NSPCs by downregulating NMDAR-CREB-BDNF signaling In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-12 Yan Zhang, Siyu Li, Ling Li, Hongmei Huang, Zhou Fu, Ziyu Hua
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Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-02 Kana Yanagihara, Yohei Hayashi, Yujung Liu, Tomoko Yamaguchi, Yasuko Hemmi, Minako Kokunugi, Kozue Uchio Yamada, Ken Fukumoto, Mika Suga, Satoshi Terada, Hiroki Nikawa, Kenji Kawabata, Miho Furue
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The effect of miR-223-3p on endothelial cells in coronary artery disease In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-28
Abstract Endothelial cell damage and dysfunction are crucial factors in the development and early stages of coronary artery disease (CAD) and apoptosis plays a significant role in this process. In this study, We aimed to simulate the CAD vascular microenvironment by treating endothelial cells with tumor necrosis factor alpha (TNF-α) to construct an endothelial cell apoptosis model. Our findings revealed
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Establishment of Capra hircus somatic cells and induction of pluripotent stem-like cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-28 Anshuman Singh, Suraj Kumar Singh, Manoj Kumar, Devojit Kumar Sarma, Samradhi Singh, Vinod Verma
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Sea buckthorn oil regulates primary myoblasts proliferation and differentiation in vitro In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-28 Jiamin Zhao, Lin Liang, Weipeng Zhang, Xuan Liu, Guoqiang Huo, Xiangdong Liu, Xiaoyang Lv, Junxing Zhao
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Effect and mechanism of hypoxia on differentiation of porcine-induced pluripotent stem cells into vascular endothelial cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-26 Yimei Li, Danyang Song, Zhuoran Yu, Yu Zhang, Zhonghua Liu, Tingsheng Yan
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Establishment and characterization of a novel lung cell line derived from the common bottlenose dolphin In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-26 Kaede Tashiro, Kyosuke Hikobe, Takao Segawa, Miwa Suzuki, Ken Maeda, Takuya Itou
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Isolation, identification, and induced differentiation of satellite cells from skeletal muscle of adult tree shrews In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-21 Shenghui Ke, Yiwei Feng, Liying Luo, Wanzhao Qin, Huayu Liu, Jingchong Nie, Beijiang Liang, Hongjie Ma, Mao Xie, Jingyu Li, Zhijie Niu, Guojian Li, Anzhou Tang, Wei Xia, Guangyao He
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LINC00467 mediates the 5-fluorouracil resistance in breast cancer cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-21 Lan Li, Yan Zhang, Yuwei Zhan, Yuanke Zhong, Xuehong Li
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Cucumber seed polypeptides regulate RANKL-induced osteoclastogenesis through OPG/RANKL/RANK and NF-κB In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-20 Tao Yu, Xiao Liu, Meng Jiang, Yuanyue Li, Heng Su, Ben Niu
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Polycaprolactone/poly l-lactic acid nanofibrous scaffold improves osteogenic differentiation of the amniotic fluid-derived stem cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-20 Seyyedeh Masoumeh Pishnamazi, Sayyed Mohammad Hossein Ghaderian, Shiva Irani, Abdolreza Ardeshirylajimi
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Decreased ZMIZ1 suppresses melanogenesis in vitiligo by regulating mTOR/AKT/GSK-3β-mediated glucose uptake In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-20 Wenli Lu, Zhuo Chen, Hui Xu, Zhengyu Shen, Zhouwei Wu, Meng Li
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Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-20 Hui Liu, Tongjuan Niu, Guobin Qiu, Sheng Cui, Di Zhang
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Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-18 Wahyunia Likhayati Septiana, Wulan Ayudyasari, Hardian Gunardi, Jeanne Adiwinata Pawitan, Gowri Manohari Balachander, Hanry Yu, Radiana Dhewayani Antarianto
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TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia–reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-15
Abstract TBC1 domain family member 25 (TBC1D25) is a crucial mediator of signal transduction involved in the development of several diseases. Particularly, a cardioprotective role of TBC1D25 has been raised due to its antagonistic action on cardiac hypertrophy. However, whether TBC1D25 protects the myocardium from ischemia–reperfusion injury has not been reported. This work aimed to determine the role
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Influence of standard culture conditions and effect of oleoresin from the microalga Haematococcus pluvialis on splenic cells from healthy Balb/c mice — a pilot study In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-07 Zuzana Jurčacková, Denisa Ciglanová, Dagmar Mudroňová, Daniela Bárcenas-Pérez, José Cheel, Gabriela Hrčková
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Downregulation of BUBR1 regulates the proliferation and cell cycle of breast cancer cells and increases the sensitivity of cells to cisplatin In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-04 Yiran Lu, Ruiqing Wang, Song He, Qing Zhang, Jiahui Wei, Jinping Hu, Yu Ding
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Epigallocatechin gallate inhibits ovarian cancer cell growth and induces cell apoptosis via activation of FOXO3A In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-01 Zhe Zhang, Qinghua Zhang, Yani Yu, Shan Su
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Myricetin ameliorates the IL-21-induced tumorigenic phenotype of adjuvant-induced arthritis FLS by modulating the choline kinase signaling cascade In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-11-30 Ann Miriam Jose, Mahaboobkhan Rasool
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Cytotoxicity of the field lampricide 3-trifluoromethyl-4-nitrophenol (TFM) in tadpole cell lines from North American frogs In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-11-27 Nguyen T. K. Vo, Stephanie J. DeWitte-Orr
The common field lampricide, 3-trifluoromethyl-4-nitrophenol (TFM), is used to treat streams and creeks infested with highly invasive and destructive sea lamprey (Petromyzon marinus) in the tributaries of the Great Lakes. Unfortunately, amphibian deaths have been reported following stream treatments with TFM. Larval amphibians (tadpoles) are more susceptible to TFM toxicity than adult amphibians. The
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Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer’s disease In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-11-21 Yaoxue Guo, Lixiang Zhang
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Identification of highly active compounds from insecticidal plant Oroxylum indicum L. (Vent.) and the induction of apoptosis by lapachol on Sf9 cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-11-15 Yujing Zhao, Jingjie An, Zhihong Dang, Jianglong Guo, Zhanlin Gao, Shujie Ma, Yaofa Li
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Vardenafil alleviates cigarette smoke-induced chronic obstructive pulmonary disease by activating autophagy via the AMPK/mTOR signalling pathway: an in vitro and in vivo study In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-11-13 Weihao Li, Jingxia Yan, Jing Xu, Liqin Zhu, Cuijuan Zhai, Yajuan Wang, Yuxin Wang, Ying Feng, Huifang Cao
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Establishment of SLC7A11‐knockout mouse and its preliminary investigation in melanoma In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-11-06 Yang Chen, Tingting Lu, Yufei Liu, Yongqi Liu, Shaocheng Bai, Qiuran Chen, Bohao Zhao, Xinsheng Wu
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Anti-oxidative activities and anti-ferroptosis of conditioned medium from umbilical cord mesenchymal stem cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-11-03 Yu-bin Liu, Lin Zhang
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Curculigoside attenuates osteoporosis through regulating DNMT1 mediated osteoblast activity In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-10-25 Mingliang Wang, Kaiying Cui, Jie Guo, Weidong Mu
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Drynaria Naringin alleviated mechanical stress deficiency-caused bone loss deterioration via Rspo1/Lgr4-mediated Wnt/β-catenin signalling pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-10-13 Gui-Xun Shi, Wei-Dong Sun, Zeng-Huan Chen, Chuan-Jun Yang, Wang-Lin Luo, Dan-Feng Wang, Ze-Zhu Zhou
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Ecliptasaponin A attenuates renal fibrosis by regulating the extracellular matrix of renal tubular cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-10-13 Xiaomin Li, Wenhui Dong, Yanlin Yang, Shijing Ren, Xiangyu Wang, Meina Zou, Wen Lu, Lerong Liu, Yaoming Xue
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Ulinastatin ameliorates podocyte ferroptosis via regulating miR-144-3p/SLC7A11 axis in acute kidney injury In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-10-11 Xiaosong Yang, Na Guo
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TRIM9 promotes Müller cell–derived retinal stem cells to differentiate into retinal ganglion cells by regulating Atoh7 In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-10-04 Qi Zeng, Jinglin Zhou, Xingyu Hua
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HIF-1α-induced upregulation of m6A reader IGF2BP1 facilitates peripheral nerve injury recovery by enhancing SLC7A11 mRNA stabilization In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-10-02 Shuai An, Jingfei Shi, Jiang Huang, Zheng Li, Mingli Feng, Guanglei Cao