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Simulation of gap junction formation reveals critical role of Cys disulfide redox state in connexin hemichannel docking Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-18 László Héja, Ágnes Simon, Julianna Kardos
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Investigation of the impact of bromodomain inhibition on cytoskeleton stability and contraction Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-16 Alexander Bigger-Allen, Ali Hashemi Gheinani, Rosalyn M. Adam
Injury to contractile organs such as the heart, vasculature, urinary bladder and gut can stimulate a pathological response that results in loss of normal contractility. PDGF and TGFβ are among the most well studied initiators of the injury response and have been shown to induce aberrant contraction in mechanically active cells of hollow organs including smooth muscle cells (SMC) and fibroblasts. However
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Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-15 Jia Chen, Wenming Ma, Shaoyu Yue, Dongsheng Li, Lei Chen, Cheng Zhang, Yu Guan, Chun Li, Changqin Jiang, Guiyi Liao, Chaozhao Liang, Hui Wang, Sheng Tai
Prostatitis is a highly prevalent condition that seriously affects men’s physical and mental health. Although epidemiological investigations have provided evidence of a correlation between insufficient sleep and prostatitis, the pathogenesis of prostatitis remains unclear. We sought to identify the underlying mechanism involved and identify a promising therapeutic target. Sleep deprivation (SD) was
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Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9 Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-15 Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo
Diabetic angiogenesis is closely associated with disabilities and death caused by diabetic microvascular complications. Advanced glycation end products (AGEs) are abnormally accumulated in diabetic patients and are a key pathogenic factor for diabetic angiogenesis. The present study focuses on understanding the mechanisms underlying diabetic angiogenesis and identifying therapeutic targets based on
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Correction: Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-14 Yu Jiang, Yi-han Dong, Shi-wei Zhao, Dong-yu Liu, Ji-yang Zhang, Xiao-ya Xu, Hao Chen, Hao Chen, Jia-bin Jin
Correction: Cell Commun Signal 22, 164 (2024) https://doi.org/10.1186/s12964-024-01545-6 Following publication of original article [1], the authors identified a production error, whereby Hao Chen (haochendr@126.com) was erroneously omitted from the author group. The author group in this correction article has been updated and the original article [1] has been corrected. The publishers apologize for
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New trends in cell death: overview of the International Society of Cell Death (ICDS) annual meeting in Johannesburg South Africa (May 19-22, 2023) Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-14 Marianne J. Cronjé, Varsha Gadiyar, Jerry Edward Chipuk, Tugba Bagci-Onder, Dmitri Krysko, Raymond B. Birge, Richard A. Lockshin, Zahra Zakeri
The International Cell Death Society (ICDS) Annual Scientific Meeting was held i n Johannesburg, South Africa on May 19–22 (https://celldeath-apoptosis.org) with “New Trends in Cell Death” as the main meeting theme. This was the 29th anniversary of the ICDS Society, a group that was started in 1994 at Rockefeller University as ‘The Death Poets Society’ by Zahra Zakeri of Queens College, Raymond Birge
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The enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-12 Tianye Li, Mengke Niu, Jianwei Zhou, Kongming Wu, Ming Yi
The programmed cell death 1 (PD-1) signaling pathway, a key player in immune checkpoint regulation, has become a focal point in cancer immunotherapy. In the context of cancer, upregulated PD-L1 on tumor cells can result in T cell exhaustion and immune evasion, fostering tumor progression. The advent of PD-1/PD-L1 inhibitor has demonstrated clinical success by unleashing T cells from exhaustion. Nevertheless
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Investigating the therapeutic effects and mechanisms of Carthamus tinctorius L.-derived nanovesicles in atherosclerosis treatment Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-12 Rongfeng Yang, Fengxia Lin, Wenlin Wang, Gang Dai, Xiao Ke, Guifu Wu
Carthamus tinctorius L., a traditional herbal medicine used for atherosclerosis (AS), lacks a clear understanding of its therapeutic mechanisms. This study aimed to investigate the therapeutic effects and mechanisms of Carthamus tinctorius L.-derived nanovesicles (CDNVs) in AS treatment. CDNVs were isolated and characterized using improved isolation methods. Transmission electron microscopy, nanoparticle
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Research progress of the chemokine/chemokine receptor axes in the oncobiology of multiple myeloma (MM) Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-12 Jun Du, Zheng Lin, Xue-Hang Fu, Xiao-Ran Gu, Guang Lu, Jian Hou
The incidence of multiple myeloma (MM), a type of blood cancer affecting monoclonal plasma cells, is rising. Although new drugs and therapies have improved patient outcomes, MM remains incurable. Recent studies have highlighted the crucial role of the chemokine network in MM’s pathological mechanism. Gaining a better understanding of this network and creating an overview of chemokines in MM could aid
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Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-12 Shuo Teng, Yi Yang, Wanru Zhang, Xiangji Li, Wenkun Li, Zilu Cui, Li Min, Jing Wu
The impact of antidepressants on Inflammatory bowel diseases (IBD) has been extensively studied. However, the biological effects and molecular mechanisms of antidepressants in alleviating colitis remain unclear. We systematically assessed how antidepressants (fluoxetine, fluvoxamine and venlafaxine) affected IBD and chose fluoxetine, the most effective one, for mechanism studies. We treated the C56BL/6
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The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-11 Aleksandra Gędaj, Aleksandra Chorążewska, Krzysztof Ciura, Radosław Karelus, Dominika Żukowska, Martyna Biaduń, Marta Kalka, Małgorzata Zakrzewska, Natalia Porębska, Łukasz Opaliński
Galectins constitute a class of lectins that specifically interact with β-galactoside sugars in glycoconjugates and are implicated in diverse cellular processes, including transport, autophagy or signaling. Since most of the activity of galectins depends on their ability to bind sugar chains, galectins exert their functions mainly in the extracellular space or at the cell surface, which are microenvironments
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Tryptophan metabolism in digestive system tumors: unraveling the pathways and implications Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-11 Liang Yu, Juan Lu, Weibo Du
Tryptophan (Trp) metabolism plays a crucial role in influencing the development of digestive system tumors. Dysregulation of Trp and its metabolites has been identified in various digestive system cancers, including esophageal, gastric, liver, colorectal, and pancreatic cancers. Aberrantly expressed Trp metabolites are associated with diverse clinical features in digestive system tumors. Moreover,
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Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-11 Shengzhe Jin, Hongfei Wang, Yang Li, Jingwen Yang, Beibei Li, Peishang Shi, Xiangrui Zhang, Xiaowen Zhou, Xiuman Zhou, Xiaoshuang Niu, Menghan Wu, Yahong Wu, Wenjie Zhai, Yuanming Qi, Yanfeng Gao, Wenshan Zhao
Targeting the tumor microenvironment (TME) has emerged as a promising strategy in cancer treatment, particularly through the utilization of immune checkpoint blockade (ICB) agents such as PD-1/PD-L1 inhibitors. Despite partial success, the presence of tumor-associated macrophages (TAMs) contributes to an immunosuppressive TME that fosters tumor progression, and diminishes the therapeutic efficacy of
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The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-09 Bo-wen Zhou, Hua-man Liu, Fei Xu, Xin-hua Jia
Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with a high mortality rate. Patients with PF commonly experience a chronic dry cough and progressive dyspnoea for years without effective mitigation. The pathogenesis of PF is believed to be associated with dysfunctional macrophage polarization, fibroblast proliferation, and the loss of epithelial cells. Thus, it is of great
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Strategies for labelling of exogenous and endogenous extracellular vesicles and their application for in vitro and in vivo functional studies Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-09 Marie Boudna, Andres Delgado Campos, Petra Vychytilova-Faltejskova, Tana Machackova, Ondrej Slaby, Kamila Souckova
This review presents a comprehensive overview of labelling strategies for endogenous and exogenous extracellular vesicles, that can be utilised both in vitro and in vivo. It covers a broad spectrum of approaches, including fluorescent and bioluminescent labelling, and provides an analysis of their applications, strengths, and limitations. Furthermore, this article presents techniques that use radioactive
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CD146+CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-08 Zhicheng Yu, Qian Zhang, Sitian Wei, Yang Zhang, Ting Zhou, Qi Zhang, Rui Shi, Dmitry Zinovkin, Zahidul Islam Pranjol, Jun Zhang, Hongbo Wang
Heterogeneous cancer-associated fibroblasts (CAFs) play important roles in cancer progression. However, the specific biological functions and regulatory mechanisms involved in endometrial cancer have yet to be elucidated. We aimed to explore the potential mechanisms of heterogeneous CAFs in promoting endometrial cancer progression. The presence of melanoma cell adhesion molecule (MCAM; CD146) positive
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The role of Bach2 in regulating CD8 + T cell development and function Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-08 Xinyu Weng, Min Zheng, Yanning Liu, Guohua Lou
Bach2 was initially discovered in B cells, where it was revealed to control the transcription involved in cell differentiation. Bach2 is intimately connected to CD8 + T lymphocytes in various differentiation states and subsets according to recent findings. Bach2 can regulate primitive T cells, stimulate the development and differentiation of memory CD8 + T cells, inhibit the differentiation of effector
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TMEM160 promotes tumor immune evasion and radiotherapy resistance via PD-L1 binding in colorectal cancer Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-07 Xiaofeng Dai, Zhipeng Wu, Ruiwen Ruan, Jingyi Chen, Chunye Huang, Wan Lei, Yangyang Yao, Li Li, Xiaomei Tang, Jianping Xiong, Miao Feng, Jun Deng
The effectiveness of anti-programmed cell death protein 1(PD-1)/programmed cell death 1 ligand 1(PD-L1) therapy in treating certain types of cancer is associated with the level of PD-L1. However, this relationship has not been observed in colorectal cancer (CRC), and the underlying regulatory mechanism of PD-L1 in CRC remains unclear. Binding of TMEM160 to PD-L1 was determined by co-immunoprecipitation
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Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-07 Zihong Wu, Yuqing Huang, Renyi Zhang, Chuan Zheng, Fengming You, Min Wang, Chong Xiao, Xueke Li
Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer (CRC), with men generally exhibiting a slightly higher incidence than women. Research suggests that this difference may be attributed to variations in sex steroid hormone levels and the gut microbiome. The gut microbiome in CRC shows variations in composition and function between the sexes, leading to the concept
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CD73/adenosine axis exerts cardioprotection against hypobaric hypoxia-induced metabolic shift and myocarditis in a sex-dependent manner Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-07 Marie Louise Ndzie Noah, Richard Mprah, Prosperl Ivette Wowui, Adebayo Oluwafemi Adekunle, Joseph Adu-Amankwaah, Rubin Tan, Zheng Gong, Tao Li, Lu Fu, Jeremiah Ong’achwa Machuki, Shijie Zhang, Hong Sun
Clinical and experimental studies have shown that the myocardial inflammatory response during pathological events varies between males and females. However, the cellular and molecular mechanisms of these sex differences remain elusive. CD73/adenosine axis has been linked to anti-inflammatory responses, but its sex-specific cardioprotective role is unclear. The present study aimed to investigate whether
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Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-06 Sinforosa Gagliardi, Marco Mitruccio, Riccardo Di Corato, Roberta Romano, Alessandra Aloisi, Rosaria Rinaldi, Pietro Alifano, Flora Guerra, Cecilia Bucci
Among the mechanisms of mitochondrial quality control (MQC), generation of mitochondria-derived vesicles (MDVs) is a process to avoid complete failure of mitochondria determining lysosomal degradation of mitochondrial damaged proteins. In this context, RAB7, a late endocytic small GTPase, controls delivery of MDVs to late endosomes for subsequent lysosomal degradation. We previously demonstrated that
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Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-06 Yu Jiang, Yi-han Dong, Shi-wei Zhao, Dong-yu Liu, Ji-yang Zhang, Xiao-ya Xu, Hao Chen, Jia-bin Jin
Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in metastatic PanNETs were not well understood. To investigate this, we performed multiregion sampling whole-exome sequencing (MRS-WES) on samples from 10 patients who had not received prior treatment for metastatic PanNETs
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Metabolism of asparagine in the physiological state and cancer Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-06 Qiong Yuan, Liyang Yin, Jun He, Qiting Zeng, Yuxin Liang, Yingying Shen, Xuyu Zu
Asparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides. Asparagine has also been reported to play a vital role in the development of cancer cells. Although several types of cancer cells can synthesise asparagine alone, their synthesis levels are insufficient to meet their
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Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-06 Jianbin Guo, Xiangwen Tang, Peng Deng, Hao Hui, Bo Chen, Jing An, Gaorong Zhang, Kuohao Shi, Jinchao Wang, Yuqing He, Dingjun Hao, Hao Yang
Microglia/macrophages are major contributors to neuroinflammation in the central nervous system (CNS) injury and exhibit either pro- or anti-inflammatory phenotypes in response to specific microenvironmental signals. Our latest in vivo and in vitro studies demonstrated that curcumin-treated olfactory ensheathing cells (aOECs) can effectively enhance neural survival and axonal outgrowth, and transplantation
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Dysregulated Gab1 signalling in triple negative breast cancer Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-06 Hannes Bongartz, Nora Mehwald, Elena A. Seiß, Tim Schumertl, Norbert Naß, Anna Dittrich
Breast cancer is the most common cancer in women worldwide. Triple-negative breast cancer (TNBC) is especially aggressive and associated with high metastasis. The aetiology of TNBC is heterogeneous and characterised by multiple different mutations that amongst others cause constitutive and dysregulated MAPK and PI3K signalling. Additionally, in more than 50% of TNBC patients, the epidermal growth factor
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Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-04 Xiaole Peng, Tianhao Wang, Qing Wang, Yuhu Zhao, Hao Xu, Huilin Yang, Ye Gu, Yunxia Tao, Bangsheng Yan, Yaozeng Xu, Dechun Geng
Estrogen deficiency-mediated hyperactive osteoclast represents the leading role during the onset of postmenopausal osteoporosis. The activation of a series of signaling cascades triggered by RANKL-RANK interaction is crucial mechanism underlying osteoclastogenesis. Vorinostat (SAHA) is a broad-spectrum pan-histone deacetylase inhibitor (HDACi) and its effect on osteoporosis remains elusive. The effects
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Role of the NF-kB signalling pathway in heterotopic ossification: biological and therapeutic significance Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-04 Fangzhou Liu, Yike Zhao, Yiran Pei, Fengyu Lian, Hui Lin
Heterotopic ossification (HO) is a pathological process in which ectopic bone develops in soft tissues within the skeletal system. Endochondral ossification can be divided into the following types of acquired and inherited ossification: traumatic HO (tHO) and fibrodysplasia ossificans progressiva (FOP). Nuclear transcription factor kappa B (NF-κB) signalling is essential during HO. NF-κB signalling
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Large-scale phosphoproteomics reveals activation of the MAPK/GADD45β/P38 axis and cell cycle inhibition in response to BMP9 and BMP10 stimulation in endothelial cells Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-04 Mohammad Al Tarrass, Lucid Belmudes, Dzenis Koça, Valentin Azemard, Hequn Liu, Tala Al Tabosh, Delphine Ciais, Agnès Desroches-Castan, Christophe Battail, Yohann Couté, Claire Bouvard, Sabine Bailly
BMP9 and BMP10 are two major regulators of vascular homeostasis. These two ligands bind with high affinity to the endothelial type I kinase receptor ALK1, together with a type II receptor, leading to the direct phosphorylation of the SMAD transcription factors. Apart from this canonical pathway, little is known. Interestingly, mutations in this signaling pathway have been identified in two rare cardiovascular
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O-GlcNAc of STING mediates antiviral innate immunity Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-01 Yujia Li, Wang An, Liyuan Lu, Jiali Yuan, Danhui Wu, Qi Yang, Jinrong Guo, Jingyu Yang, Mengjie Liu, Kaiyue He, Xinyuan Lei, Zhi-Xiang Xu
O-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered O-GlcNAcylation was reported to participate in antivirus response. Stimulator of interferon genes (STING) is an adaptor mediating DNA virus-induced innate immune response. Whether STING is able to be modified by O-GlcNAcylation and how O-GlcNAcylation affects STING-mediated anti-DNA virus response
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Exosomes derived from programmed cell death: mechanism and biological significance Cell Commun. Signal. (IF 8.4) Pub Date : 2024-03-01 Min Xiong, Zhen Chen, Jiaqi Tian, Yanjie Peng, Dandan Song, Lin Zhang, Yulan Jin
Exosomes are nanoscale extracellular vesicles present in bodily fluids that mediate intercellular communication by transferring bioactive molecules, thereby regulating a range of physiological and pathological processes. Exosomes can be secreted from nearly all cell types, and the biological function of exosomes is heterogeneous and depends on the donor cell type and state. Recent research has revealed
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Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-29 Yudong Liu, Zixiang Luo, Yong Xie, Yi Sun, Feifei Yuan, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
Vascular endothelial cells are pivotal in the pathophysiological progression following spinal cord injury (SCI). The UTX (Ubiquitously Transcribed Tetratripeptide Repeat on Chromosome X) serves as a significant regulator of endothelial cell phenotype. The manipulation of endogenous neural stem cells (NSCs) offers a compelling strategy for the amelioration of SCI. Two mouse models were used to investigate
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Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-28 Guy Nadel, Zhong Yao, Avital Hacohen-Lev-Ran, Ehud Wainstein, Galia Maik-Rachline, Tamar Ziv, Zvi Naor, Arie Admon, Rony Seger
Although GqPCR activation often leads to cell survival by activating the PI3K/AKT pathway, it was previously shown that in several cell types AKT activity is reduced and leads to JNK activation and apoptosis. The mechanism of AKT inactivation in these cells involves an IGBP1-coupled PP2Ac switch that induces the dephosphorylation and inactivation of both PI3K and AKT. However, the machinery involved
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KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-27 Shishan Zhou, Omar Abdihamid, Fengbo Tan, Haiyan Zhou, Heli Liu, Zhi Li, Sheng Xiao, Bin Li
Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage. Both ICC and GIST cells highly rely on KIT signal pathway. Clinically, about 80-90% of treatment-naive GIST patients harbor primary KIT mutations, and special KIT-targeted TKI, imatinib (IM) showing dramatic efficacy but resistance invariably
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E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-27 Joana Pereira, Soraia Melo, Rui M. Ferreira, Patrícia Carneiro, Vítor Yang, André F. Maia, João Carvalho, Ceu Figueiredo, José Carlos Machado, Eurico Morais-de-Sá, Raquel Seruca, Joana Figueiredo
Germline mutations of E-cadherin contribute to hereditary diffuse gastric cancer (HDGC) and congenital malformations, such as oral facial clefts (OFC). However, the molecular mechanisms through which E-cadherin loss-of-function triggers distinct clinical outcomes remain unknown. We postulate that E-cadherin-mediated disorders result from abnormal interactions with the extracellular matrix and consequent
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The in vitro and in vivo depigmentation activity of coenzyme Q0, a major quinone derivative from Antrodia camphorata, through autophagy induction in human melanocytes and keratinocytes Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-26 You-Cheng Hseu, Jou-Tsen Yeh, Chithravel Vadivalagan, Siang-Jyun Chen, Yugandhar Vudhya Gowrisankar, Sudhir Pandey, Yuan-Tai Hsu, Hung-Rong Yen, Hui-Chi Huang, Jhih-Hsuan Hseu, Hsin-Ling Yang
Coenzyme Q0 (CoQ0), a novel quinone derivative of Antrodia camphorata, has been utilized as a therapeutic agent (including antioxidant, anti-inflammatory, antiangiogenic, antiatherosclerotic, and anticancer agents); however, its depigmenting efficiency has yet to be studied. We resolved the depigmenting efficiency of CoQ0 through autophagy induction in melanoma (B16F10) and melanin-feeding keratinocyte
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Palmitoylation of vacuole membrane protein 1 promotes small extracellular vesicle secretion via interaction with ALIX and influences intercellular communication Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-26 Mengyuan Qu, Xinyu Liu, Xiaotong Wang, Zili Li, Liquan Zhou, Honggang Li
Small extracellular vesicles (EVs), exemplified by exosomes, mediate intercellular communication by transporting proteins, mRNAs, and miRNAs. Post-translational modifications are involved in controlling small EV secretion process. However, whether palmitoylation regulates small EV secretion, remains largely unexplored. Vacuole Membrane Protein 1 (VMP1) was testified to be S-palmitoylated by Palmitoylation
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Apoptosis dysfunction: unravelling the interplay between ZBP1 activation and viral invasion in innate immune responses Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-24 Jianhao Zhan, Jisheng Wang, Yuqing Liang, Lisha Wang, Le Huang, Shanshan Liu, Xiaoping Zeng, Erming Zeng, Hongmei Wang
Apoptosis plays a pivotal role in pathogen elimination and maintaining homeostasis. However, viruses have evolved strategies to evade apoptosis, enabling their persistence within the host. Z-DNA binding protein 1 (ZBP1) is a potent innate immune sensor that detects cytoplasmic nucleic acids and activates the innate immune response to clear pathogens. When apoptosis is inhibited by viral invasion, ZBP1
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Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-24 Marie-Christin Schulz, Michael Kopf, Michael Gekle
Tubulointerstitial kidney disease associated microenvironmental dysregulation, like acidification, inflammation and fibrosis, affects tubule cells and fibroblasts. Micromilieu homeostasis influences intracellular signaling and intercellular crosstalk. Cell–cell communication in turn modulates the interstitial microenvironment. We assessed the impact of acidosis on inflammatory and fibrotic responses
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Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer’s disease Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-22 Rui Mao, Mengsha Hu, Xuan Liu, Lei Ye, Bingsong Xu, Min Sun, Siyi Xu, Wenxuan Shao, Yi Tan, Yun Xu, Feng Bai, Shu Shu
Patients with Alzheimer’s disease (AD) are often co-morbid with unprovoked seizures, making clinical diagnosis and management difficult. Although it has an important role in both AD and epilepsy, abnormal γ-aminobutyric acid (GABA)ergic transmission is recognized only as a compensative change for glutamatergic damage. Neuregulin 1 (NRG1)-ErbB4 signaling can promote GABA release and suppress epileptogenesis
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Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-22 Jing Du, Lingyan Yu, Xinyi Yang, Fangchun Shao, Jun Xia, Weidong Jin, Yinhao Zhang, Guojie Lei, Ying Wang, Yanchun Li, Jun Zhang
Paraquat (PQ) is an irreplaceable insecticide in many countries for the advantage of fast-acting and broad-spectrum. However, PQ was classified as the most prevailing poisoning substance for suicide with no specific antidote. Therefore, it is imperative to develop more effective therapeutic agents for the treatment of PQ poisoning. In the present study, both the RNA-Seq and the application of various
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CD73 mitigates ZEB1 expression in papillary thyroid carcinoma Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-22 Samlai Vedovatto, Fernanda Dittrich Oliveira, Luiza Cherobini Pereira, Thamiris Becker Scheffel, Liziane Raquel Beckenkamp, Ana Paula Santin Bertoni, Márcia Rosângela Wink, Guido Lenz
ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor prognosis across various tumor types. Similarly, the expression and activity of CD73, an ectonucleotidase implicated in adenosine generation, is an important marker of tumor malignancy. Growing evidence suggests that EMT and the adenosinergic
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Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-22 Stoyan Tankov, Marija Petrovic, Marc Lecoultre, Felipe Espinoza, Nadia El-Harane, Viviane Bes, Sylvie Chliate, Darel Martinez Bedoya, Olivier Jordan, Gerrit Borchard, Denis Migliorini, Valérie Dutoit, Paul R. Walker
Solid tumors such as glioblastoma (GBM) exhibit hypoxic zones that are associated with poor prognosis and immunosuppression through multiple cell intrinsic mechanisms. However, release of extracellular vesicles (EVs) has the potential to transmit molecular cargos between cells. If hypoxic cancer cells use EVs to suppress functions of macrophages under adequate oxygenation, this could be an important
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Phase separation-mediated biomolecular condensates and their relationship to tumor Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-21 Xi Wang, Jiameng Liu, Chaoming Mao, Yufei Mao
Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets" and forming distinct, membrane-free compartments. This process is pervasive in biological cells, contributing to various essential cellular functions. However, when phase separation goes awry, leading to abnormal molecular aggregation, it can become a
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TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-21 Laxman Manandhar, Raghbendra Kumar Dutta, Pradeep Devkota, Arun Chhetri, Xiaofan Wei, Channy Park, Hyug Moo Kwon, Raekil Park
Calcium is a ubiquitous intracellular messenger that regulates the expression of various genes involved in cell proliferation, differentiation, and motility. The involvement of calcium in diverse metabolic pathways has been suggested. However, the effect of calcium in peroxisomes, which are involved in fatty acid oxidation and scavenges the result reactive oxygen species (ROS), remains elusive. In
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Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-21 Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L. Eizirik, Bobbie-Jo M. Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O. Metz, Raghavendra G. Mirmira, Lori
Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death. We performed lipidomics using three models of insulitis: human islets and EndoC-βH1 β cells treated with the pro-inflammatory cytokines interlukine-1β and interferon-γ
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Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-20 Jie Jia, Lianhui Zhu, Xihua Yue, Shuocheng Tang, Shuaiyang Jing, Chuanting Tan, Yulei Du, Jingkai Gao, Intaek Lee, Yi Qian
Hostile microenvironment of cancer cells provoke a stressful condition for endoplasmic reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to tumorigenic effects. However, the molecular mechanism underlying these effects is largely unknown. In this study, we reveal that the last four residues of ER chaperones, which are recognized by KDEL receptor (KDELR), is required
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Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-20 Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang, Gang Liu
Malaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major challenge to malaria control. There is an urgent need to find new drugs or strategies to alleviate this predicament. Celastrol (Cel) is an extensively studied natural bioactive compound that has shown potentially promising antimalarial activity, but its antimalarial
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Liquid plasma promotes angiogenesis through upregulation of endothelial nitric oxide synthase-induced extracellular matrix metabolism: potential applications of liquid plasma for vascular injuries Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-19 Sung Un Kang, Haeng Jun Kim, Sukhwal Ma, Doo-Yi Oh, Jeon Yeob Jang, Chorong Seo, Yun Sang Lee, Chul-Ho Kim
Applications of nonthermal plasma have expanded beyond the biomedical field to include antibacterial, anti-inflammatory, wound healing, and tissue regeneration. Plasma enhances epithelial cell repair; however, the potential damage to deep tissues and vascular structures remains under investigation. This study assessed whether liquid plasma (LP) increased nitric oxide (NO) production in human umbilical
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A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-19 Brian G. Poll, Kirby T. Leo, Venky Deshpande, Nipun Jayatissa, Trairak Pisitkun, Euijung Park, Chin-Rang Yang, Viswanathan Raghuram, Mark A. Knepper
Protein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes, and is mediated by over 520 protein kinases in humans and other mammals. Identification of the protein kinases responsible for phosphorylation events is key to understanding signaling pathways. Unbiased phosphoproteomics experiments have generated a wealth of data
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Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-19 Shiwan Hu, Xing Hang, Yu Wei, Han Wang, Lili Zhang, Linhua Zhao
Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that affects millions of people worldwide. It is characterized by proteinuria, glomerular damage, and renal fibrosis, leading to end-stage renal disease, and the pathogenesis is complex and involves multiple cellular and molecular mechanisms. Among three kinds of intraglomerular cells including podocytes, glomerular endothelial
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High estrogen during ovarian stimulation induced loss of maternal imprinted methylation that is essential for placental development via overexpression of TET2 in mouse oocytes Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-19 Xueyan Lu, Jiaqin Mao, Chenxi Qian, Hui Lei, Fei Mu, Huijun Sun, Song Yan, Zheng Fang, Jie Lu, Qian Xu, Jie Dong, Danjie Su, Jingjing Wang, Ni Jin, Shuqiang Chen, Xiaohong Wang
Ovarian stimulation (OS) during assisted reproductive technology (ART) appears to be an independent factor influencing the risk of low birth weight (LBW). Previous studies identified the association between LBW and placenta deterioration, potentially resulting from disturbed genomic DNA methylation in oocytes caused by OS. However, the mechanisms by which OS leads to aberrant DNA methylation patterns
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Dopamine enhances recovery after traumatic brain injury through ubiquitylation and autophagic degradation of RIPK1 Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-19 Hui Luo, Ning Liu, Chao Lin
Although the neurotransmitter dopamine (DA) plays a crucial pathophysiologic role after traumatic brain injury (TBI), its function and specific underlying mechanisms of action remain unclear. Adult male mice underwent controlled cortical impact (CCI). We administered DA intraperitoneally to mice for 14 consecutive days, starting 8 h before CCI. On day 3 after brain injury, cortical lesion volume and
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Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-17 Sandy Anania, Martin Farnir, Raphaël Peiffer, Yasmine Boumahd, Marc Thiry, Ferman Agirman, Naima Maloujahmoum, Akeila Bellahcène, Olivier Peulen
Pancreatic ductal adenocarcinoma is an aggressive cancer type with one of the lowest survival rates due to late diagnosis and the absence of effective treatments. A better understanding of PDAC biology will help researchers to discover the Achilles’ heel of cancer cells. In that regard, our research team investigated the function of an emerging oncoprotein known as myoferlin. Myoferlin is overexpressed
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Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-17 Xiaotong Xu, Yi Han, Binlong Zhang, Quanzhong Ren, Juan Ma, Sijin Liu
Abnormal inflammatory states in the brain are associated with a variety of brain diseases. The dynamic changes in the number and function of immune cells in cerebrospinal fluid (CSF) are advantageous for the early prediction and diagnosis of immune diseases affecting the brain. The aggregated factors and cells in inflamed CSF may represent candidate targets for therapy. The physiological barriers in
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The dynamic role of nucleoprotein SHCBP1 in the cancer cell cycle and its potential as a synergistic target for DNA-damaging agents in cancer therapy Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-16 Mei Zhou, Limin Duan, Jiangbin Chen, Yumei Li, Zhengrong Yin, Siwei Song, Yaqi Cao, Ping Luo, Fan Hu, Guanghai Yang, Juanjuan Xu, Tingting Liao, Yang Jin
Malignant tumours seriously threaten human life and health, and effective treatments for cancer are still being explored. The ability of SHC SH2 domain-binding protein 1 (SHCBP1) to induce cell cycle disturbance and inhibit tumour growth has been increasingly studied, but its dynamic role in the tumour cell cycle and corresponding effects leading to mitotic catastrophe and DNA damage have rarely been
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Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-15 Zahra Abbasi-Malati, Seyed Ghader Azizi, Soheil Zamen Milani, Zeinab Aliyari Serej, Narges Mardi, Zahra Amiri, Zohreh Sanaat, Reza Rahbarghazi
In recent decades, emerging data have highlighted the critical role of extracellular vesicles (EVs), especially (exosomes) Exos, in the progression and development of several cancer types. These nano-sized vesicles are released by different cell lineages within the cancer niche and maintain a suitable platform for the interchange of various signaling molecules in a paracrine manner. Based on several
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Targeting cancer-derived extracellular vesicles by combining CD147 inhibition with tissue factor pathway inhibitor for the management of urothelial cancer cells Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-15 Vijay Kumar Boddu, Piet Zamzow, Mario Wolfgang Kramer, Axel S. Merseburger, Sivahari Prasad Gorantla, Matthias Klinger, Lena Cramer, Thorben Sauer, Timo Gemoll, Nikolas von Bubnoff, Frank Gieseler, Masoud Darabi
Extracellular vesicles (EVs), including microvesicles, hold promise for the management of bladder urothelial carcinoma (BLCA), particularly because of their utility in identifying therapeutic targets and their diagnostic potential using easily accessible urine samples. Among the transmembrane glycoproteins highly enriched in cancer-derived EVs, tissue factor (TF) and CD147 have been implicated in promoting
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Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF-β signaling responses in ovarian cancer Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-15 Alex S. Choi, Laura M. Jenkins-Lane, Wade Barton, Asha Kumari, Carly Lancaster, Calen Raulerson, Hao Ji, Diego Altomare, Mark D. Starr, Regina Whitaker, Rebecca Phaeton, Rebecca Arend, Michael Shtutman, Andrew B. Nixon, Nadine Hempel, Nam Y. Lee, Karthikeyan Mythreye
In pathologies including cancer, aberrant Transforming Growth Factor-β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathway. Central to the success of these interventions is pinpointing factors that decisively modulate the TGF-β responses. Betaglycan/type III TGF-β receptor (TβRIII), is an established co-receptor
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Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-15 Maria Azzurra Caricasulo, Adriana Zanetti, Mineko Terao, Enrico Garattini, Gabriela Paroni
All-trans retinoic acid (ATRA) is the most relevant and functionally active metabolite of Vitamin-A. From a therapeutic standpoint, ATRA is the first example of pharmacological agent exerting its anti-tumor activity via a cell differentiating action. In the clinics, ATRA is used in the treatment of Acute Promyelocytic Leukemia, a rare form of myeloid leukemia with unprecedented therapeutic results
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COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches Cell Commun. Signal. (IF 8.4) Pub Date : 2024-02-15 Sareh Kakavandi, Bahareh Hajikhani, Paniz Azizi, Fatemeh Aziziyan, Mohsen Nabi-Afjadi, Marzieh Ramezani Farani, Hamidreza Zalpoor, Maryam Azarian, Mahdiyar Iravani Saadi, Behrouz Gharesi-Fard, Evangelos Terpos, Iman Zare, Mohammad Motamedifar
Extensive research in countries with high sociodemographic indices (SDIs) to date has shown that coronavirus disease 2019 (COVID-19) may be directly associated with more severe outcomes among patients living with haematological disorders and malignancies (HDMs). Because individuals with moderate to severe immunodeficiency are likely to undergo persistent infections, shed virus particles for prolonged